Search

Your search keyword '"Quintana, Elsa"' showing total 171 results
Start Over Author "Quintana, Elsa"
171 results on '"Quintana, Elsa"'

2. Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

Author

Wasko, Urszula N., Jiang, Jingjing, Dalton, Tanner C., Curiel-Garcia, Alvaro, Edwards, A. Cole, Wang, Yingyun, Lee, Bianca, Orlen, Margo, Tian, Sha, Stalnecker, Clint A., Drizyte-Miller, Kristina, Menard, Marie, Dilly, Julien, Sastra, Stephen A., Palermo, Carmine F., Hasselluhn, Marie C., Decker-Farrell, Amanda R., Chang, Stephanie, Jiang, Lingyan, Wei, Xing, Yang, Yu C., Helland, Ciara, Courtney, Haley, Gindin, Yevgeniy, Muonio, Karl, Zhao, Ruiping, Kemp, Samantha B., Clendenin, Cynthia, Sor, Rina, Vostrejs, William P., Hibshman, Priya S., Amparo, Amber M., Hennessey, Connor, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Brodbeck, Jens, Tomassoni, Lorenzo, Bakir, Basil, Socci, Nicholas D., Herring, Laura E., Barker, Natalie K., Wang, Junning, Cleary, James M., Wolpin, Brian M., Chabot, John A., Kluger, Michael D., Manji, Gulam A., Tsai, Kenneth Y., Sekulic, Miroslav, Lagana, Stephen M., Califano, Andrea, Quintana, Elsa, Wang, Zhengping, Smith, Jacqueline A. M., Holderfield, Matthew, Wildes, David, Lowe, Scott W., Badgley, Michael A., Aguirre, Andrew J., Vonderheide, Robert H., Stanger, Ben Z., Baslan, Timour, Der, Channing J., Singh, Mallika, and Olive, Kenneth P.

Published
2024
Full Text
View/download PDF

3. Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

Author

Holderfield, Matthew, Lee, Bianca J., Jiang, Jingjing, Tomlinson, Aidan, Seamon, Kyle J., Mira, Alessia, Patrucco, Enrico, Goodhart, Grace, Dilly, Julien, Gindin, Yevgeniy, Dinglasan, Nuntana, Wang, Yingyun, Lai, Lick Pui, Cai, Shurui, Jiang, Lingyan, Nasholm, Nicole, Shifrin, Nataliya, Blaj, Cristina, Shah, Harshit, Evans, James W., Montazer, Nilufar, Lai, Oliver, Shi, Jade, Ahler, Ethan, Quintana, Elsa, Chang, Stephanie, Salvador, Anthony, Marquez, Abby, Cregg, Jim, Liu, Yang, Milin, Anthony, Chen, Anqi, Ziv, Tamar Bar, Parsons, Dylan, Knox, John E., Klomp, Jennifer E., Roth, Jennifer, Rees, Matthew, Ronan, Melissa, Cuevas-Navarro, Antonio, Hu, Feng, Lito, Piro, Santamaria, David, Aguirre, Andrew J., Waters, Andrew M., Der, Channing J., Ambrogio, Chiara, Wang, Zhengping, Gill, Adrian L., Koltun, Elena S., Smith, Jacqueline A. M., Wildes, David, and Singh, Mallika

Published
2024
Full Text
View/download PDF

4. Author Correction: Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

Author

Wasko, Urszula N., Jiang, Jingjing, Dalton, Tanner C., Curiel-Garcia, Alvaro, Edwards, A. Cole, Wang, Yingyun, Lee, Bianca, Orlen, Margo, Tian, Sha, Stalnecker, Clint A., Drizyte-Miller, Kristina, Menard, Marie, Dilly, Julien, Sastra, Stephen A., Palermo, Carmine F., Hasselluhn, Marie C., Decker-Farrell, Amanda R., Chang, Stephanie, Jiang, Lingyan, Wei, Xing, Yang, Yu C., Helland, Ciara, Courtney, Haley, Gindin, Yevgeniy, Muonio, Karl, Zhao, Ruiping, Kemp, Samantha B., Clendenin, Cynthia, Sor, Rina, Vostrejs, William P., Hibshman, Priya S., Amparo, Amber M., Hennessey, Connor, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Brodbeck, Jens, Tomassoni, Lorenzo, Bakir, Basil, Socci, Nicholas D., Herring, Laura E., Barker, Natalie K., Wang, Junning, Cleary, James M., Wolpin, Brian M., Chabot, John A., Kluger, Michael D., Manji, Gulam A., Tsai, Kenneth Y., Sekulic, Miroslav, Lagana, Stephen M., Califano, Andrea, Quintana, Elsa, Wang, Zhengping, Smith, Jacqueline A. M., Holderfield, Matthew, Wildes, David, Lowe, Scott W., Badgley, Michael A., Aguirre, Andrew J., Vonderheide, Robert H., Stanger, Ben Z., Baslan, Timour, Der, Channing J., Singh, Mallika, and Olive, Kenneth P.

Published
2024
Full Text
View/download PDF

5. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity

Author

Myers, Darienne R, Abram, Clare L, Wildes, David, Belwafa, Amira, Welsh, Alia MN, Schulze, Christopher J, Choy, Tiffany J, Nguyen, Tram, Omaque, Neil, Hu, Yongmei, Singh, Mallika, Hansen, Rich, Goldsmith, Mark A, Quintana, Elsa, Smith, Jacqueline AM, and Lowell, Clifford A

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Vaccine Related, Immunotherapy, Immunization, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Adaptive Immunity, Adenocarcinoma, Animals, Antigens, Differentiation, Breast Neoplasms, Colonic Neoplasms, Female, Humans, Immunity, Innate, Lymphocytes, Tumor-Infiltrating, Melanoma, Experimental, Mice, Inbred C57BL, Mice, Knockout, Phagocytosis, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Receptors, Immunologic, Signal Transduction, Skin Neoplasms, THP-1 Cells, Tumor Burden, Tumor Microenvironment, Tumor-Associated Macrophages, tyrosine phosphatase, phagocytosis, PTPN6, immuno-oncology, SIRP alpha, inflammation, SIRPα, Medical Microbiology, Biochemistry and cell biology, Genetics
Abstract

Shp1, encoded by the gene Ptpn6, is a protein tyrosine phosphatase that transduces inhibitory signals downstream of immunoreceptors in many immune cell types. Blocking Shp1 activity represents an exciting potential immunotherapeutic strategy for the treatment of cancer, as Shp1 inhibition would be predicted to unleash both innate and adaptive immunity against tumor cells. Antibodies blocking the interaction between CD47 on tumor cells and SIRPα on macrophages enhance macrophage phagocytosis, show efficacy in preclinical tumor models, and are being evaluated in the clinic. Here we found that Shp1 bound to phosphorylated peptide sequences derived from SIRPα and transduced the anti-phagocytic signal, as Shp1 loss in mouse bone marrow-derived macrophages increased phagocytosis of tumor cells in vitro. We also generated a novel mouse model to evaluate the impact of global, inducible Ptpn6 deletion on anti-tumor immunity. We found that inducible Shp1 loss drove an inflammatory disease in mice that was phenotypically similar to that seen when Ptpn6 is knocked out from birth. This indicates that acute perturbation of Shp1 in vivo could drive hyperactivation of immune cells, which could be therapeutically beneficial, though at the risk of potential toxicity. In this model, we found that Shp1 loss led to robust anti-tumor immunity against two immune-rich syngeneic tumor models that are moderately inflamed though not responsive to checkpoint inhibitors, MC38 and E0771. Shp1 loss did not promote anti-tumor activity in the non-inflamed B16F10 model. The observed activity in MC38 and E0771 tumors was likely due to effects of both innate and adaptive immune cells. Following Shp1 deletion, we observed increases in intratumoral myeloid cells in both models, which was more striking in E0771 tumors. E0771 tumors also contained an increased ratio of effector to regulatory T cells following Shp1 loss. This was not observed for MC38 tumors, though we did find increased levels of IFNγ, a cytokine produced by effector T cells, in these tumors. Overall, our preclinical data suggested that targeting Shp1 may be an attractive therapeutic strategy for boosting the immune response to cancer via a mechanism involving both innate and adaptive leukocytes.

Published
2020

7. Supplementary Table S8 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers

Author

Jiang, Jingjing, primary, Jiang, Lingyan, primary, Maldonato, Benjamin J., primary, Wang, Yingyun, primary, Holderfield, Matthew, primary, Aronchik, Ida, primary, Winters, Ian P., primary, Salman, Zeena, primary, Blaj, Cristina, primary, Menard, Marie, primary, Brodbeck, Jens, primary, Chen, Zhe, primary, Wei, Xing, primary, Rosen, Michael J., primary, Gindin, Yevgeniy, primary, Lee, Bianca J., primary, Evans, James W., primary, Chang, Stephanie, primary, Wang, Zhican, primary, Seamon, Kyle J., primary, Parsons, Dylan, primary, Cregg, James, primary, Marquez, Abby, primary, Tomlinson, Aidan C.A., primary, Yano, Jason K., primary, Knox, John E., primary, Quintana, Elsa, primary, Aguirre, Andrew J., primary, Arbour, Kathryn C., primary, Reed, Abby, primary, Gustafson, W. Clay, primary, Gill, Adrian L., primary, Koltun, Elena S., primary, Wildes, David, primary, Smith, Jacqueline A.M., primary, Wang, Zhengping, primary, and Singh, Mallika, primary

Published
2024
Full Text
View/download PDF

8. Supplementary Figure S1-S6 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers

Author

Jiang, Jingjing, primary, Jiang, Lingyan, primary, Maldonato, Benjamin J., primary, Wang, Yingyun, primary, Holderfield, Matthew, primary, Aronchik, Ida, primary, Winters, Ian P., primary, Salman, Zeena, primary, Blaj, Cristina, primary, Menard, Marie, primary, Brodbeck, Jens, primary, Chen, Zhe, primary, Wei, Xing, primary, Rosen, Michael J., primary, Gindin, Yevgeniy, primary, Lee, Bianca J., primary, Evans, James W., primary, Chang, Stephanie, primary, Wang, Zhican, primary, Seamon, Kyle J., primary, Parsons, Dylan, primary, Cregg, James, primary, Marquez, Abby, primary, Tomlinson, Aidan C.A., primary, Yano, Jason K., primary, Knox, John E., primary, Quintana, Elsa, primary, Aguirre, Andrew J., primary, Arbour, Kathryn C., primary, Reed, Abby, primary, Gustafson, W. Clay, primary, Gill, Adrian L., primary, Koltun, Elena S., primary, Wildes, David, primary, Smith, Jacqueline A.M., primary, Wang, Zhengping, primary, and Singh, Mallika, primary

Published
2024
Full Text
View/download PDF

9. Supplementary Method from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers

Author

Jiang, Jingjing, primary, Jiang, Lingyan, primary, Maldonato, Benjamin J., primary, Wang, Yingyun, primary, Holderfield, Matthew, primary, Aronchik, Ida, primary, Winters, Ian P., primary, Salman, Zeena, primary, Blaj, Cristina, primary, Menard, Marie, primary, Brodbeck, Jens, primary, Chen, Zhe, primary, Wei, Xing, primary, Rosen, Michael J., primary, Gindin, Yevgeniy, primary, Lee, Bianca J., primary, Evans, James W., primary, Chang, Stephanie, primary, Wang, Zhican, primary, Seamon, Kyle J., primary, Parsons, Dylan, primary, Cregg, James, primary, Marquez, Abby, primary, Tomlinson, Aidan C.A., primary, Yano, Jason K., primary, Knox, John E., primary, Quintana, Elsa, primary, Aguirre, Andrew J., primary, Arbour, Kathryn C., primary, Reed, Abby, primary, Gustafson, W. Clay, primary, Gill, Adrian L., primary, Koltun, Elena S., primary, Wildes, David, primary, Smith, Jacqueline A.M., primary, Wang, Zhengping, primary, and Singh, Mallika, primary

Published
2024
Full Text
View/download PDF

10. Data from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers

Author

Jiang, Jingjing, primary, Jiang, Lingyan, primary, Maldonato, Benjamin J., primary, Wang, Yingyun, primary, Holderfield, Matthew, primary, Aronchik, Ida, primary, Winters, Ian P., primary, Salman, Zeena, primary, Blaj, Cristina, primary, Menard, Marie, primary, Brodbeck, Jens, primary, Chen, Zhe, primary, Wei, Xing, primary, Rosen, Michael J., primary, Gindin, Yevgeniy, primary, Lee, Bianca J., primary, Evans, James W., primary, Chang, Stephanie, primary, Wang, Zhican, primary, Seamon, Kyle J., primary, Parsons, Dylan, primary, Cregg, James, primary, Marquez, Abby, primary, Tomlinson, Aidan C.A., primary, Yano, Jason K., primary, Knox, John E., primary, Quintana, Elsa, primary, Aguirre, Andrew J., primary, Arbour, Kathryn C., primary, Reed, Abby, primary, Gustafson, W. Clay, primary, Gill, Adrian L., primary, Koltun, Elena S., primary, Wildes, David, primary, Smith, Jacqueline A.M., primary, Wang, Zhengping, primary, and Singh, Mallika, primary

Published
2024
Full Text
View/download PDF

11. Combining RASG12C(ON) inhibitor with SHP2 inhibition sensitises immune excluded lung tumours to immune checkpoint blockade: a strategy for turning cold tumours hot

Author

Anastasiou, Panayiotis, primary, Moore, Christopher, additional, Rana, Sareena, additional, de Castro, Andrea, additional, Tomaschko, Mona, additional, Boumelha, Jesse, additional, Mugarza, Edurne, additional, Blaj, Cristina, additional, de Carné, Sophie, additional, Goldstone, Robert, additional, Smith, Jacqueline A.M., additional, Quintana, Elsa, additional, Molina-Arcas, Miriam, additional, and Downward, Julian, additional

Published
2024
Full Text
View/download PDF

12. Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma

Author

Wasko, Urszula N., primary, Jiang, Jingjing, additional, Curiel-Garcia, Alvaro, additional, Wang, Yingyun, additional, Lee, Bianca, additional, Orlen, Margo, additional, Drizyte-Miller, Kristina, additional, Menard, Marie, additional, Dilly, Julien, additional, Sastra, Stephen A., additional, Palermo, Carmine F., additional, Dalton, Tanner, additional, Hasselluhn, Marie C., additional, Decker-Farrell, Amanda R., additional, Chang, Stephanie, additional, Jiang, Lingyan, additional, Wei, Xing, additional, Yang, Yu C., additional, Helland, Ciara, additional, Courtney, Haley, additional, Gindin, Yevgeniy, additional, Zhao, Ruiping, additional, Kemp, Samantha B., additional, Clendenin, Cynthia, additional, Sor, Rina, additional, Vostrejs, Will, additional, Amparo, Amber A., additional, Hibshman, Priya S., additional, Rees, Matthew G., additional, Ronan, Melissa M., additional, Roth, Jennifer A., additional, Bakir, Basil, additional, Badgley, Michael A., additional, Chabot, John A., additional, Kluger, Michael D., additional, Manji, Gulam A., additional, Quintana, Elsa, additional, Wang, Zhengping, additional, Smith, Jacqueline A. M., additional, Holderfield, Matthew, additional, Wildes, David, additional, Aguirre, Andrew J., additional, Der, Channing J., additional, Vonderheide, Robert H., additional, Stanger, Ben Z., additional, Singh, Mallika, additional, and Olive, Kenneth P., additional

Published
2023
Full Text
View/download PDF

14. Abstract LB015: Bi-steric mTORC1-selective inhibitors activate 4EBP1, suppress MYC, restore anti-tumor immunity, and cooperate with immune checkpoint inhibition to elicit tumor regression

Author

Mahauad-Fernandez, Wadie D., primary, Yang, Yu Chi, additional, Lai, Ian, additional, Park, Jangho, additional, Yao, Lilian, additional, Evans, James W., additional, Atibalentja, Danielle F., additional, Chen, Xinyu, additional, Zhao, Zihui, additional, Burnett, G. Leslie, additional, Lee, Bianca J., additional, Dinglasan, Nuntana, additional, Shifrin, Nataliya, additional, Ahler, Ethan, additional, Quintana, Elsa, additional, Gill, Adrian, additional, Smith, Jacqueline A., additional, Singh, Mallika, additional, and Felsher, Dean W., additional

Published
2023
Full Text
View/download PDF

15. Abstract 526: RMC-9805, a first-in-class, mutant-selective, covalent and oral KRASG12D(ON) inhibitor that induces apoptosis and drives tumor regression in preclinical models of KRASG12D cancers

Author

Jiang, Lingyan, primary, Menard, Marie, additional, Weller, Caroline, additional, Wang, Zhican, additional, Burnett, Les, additional, Aronchik, Ida, additional, Steele, Shelby, additional, Flagella, Mike, additional, Zhao, Ruiping, additional, Evans, James W W., additional, Chin, Shook, additional, Chou, Kang-Jye, additional, Mu, Yunming, additional, Longhi, Michael, additional, McDowell, Laura, additional, Knox, John E., additional, Gill, Adrian, additional, Smith, Jacqueline A., additional, Singh, Mallika, additional, Quintana, Elsa, additional, and Jiang, Jingjing, additional

Published
2023
Full Text
View/download PDF

16. Abstract 3475: RMC-9805, a first-in-class, mutant-selective, covalent and orally bioavailable KRASG12D(ON) inhibitor, promotes cancer-associated neoantigen recognition and synergizes with immunotherapy in preclinical models

Author

Menard, Marie J., primary, Chow, Christopher, additional, Chen, Kevin, additional, Blaj, Cristina, additional, Shifrin, Nataliya Tovbis, additional, Courtney, Haley, additional, Nasholm, Nicole M., additional, Pham, Anna, additional, Kumamoto, Alice, additional, Ganesh, Swetha, additional, Evans, James W., additional, Lawrence, Lindsey, additional, Vonmelchert, Brian, additional, Kwok-Parkhill, Amy C., additional, Jiang, Jingjing, additional, Knox, John E., additional, Smith, Jacqueline, additional, and Quintana, Elsa, additional

Published
2023
Full Text
View/download PDF

18. Abstract 3597: Direct targeting of KRASG12X mutant cancers with RMC-6236, a first-in-class, RAS-selective, orally bioavailable, tri-complex RASMULTI(ON) inhibitor

Author

Koltun, Elena S., primary, Rice, Meghan A., additional, Gustafson, W. Clay, additional, Wilds, David, additional, Jiang, Jingjing, additional, Lee, Bianca J., additional, Wang, Zhengping, additional, Chang, Stephanie, additional, Flagella, Mike, additional, Mu, Yunming, additional, Dinglasan, Nuntana, additional, Nasholm, Nicole, additional, Evans, James W., additional, Wang, Yingyun, additional, Seamon, Kyle, additional, Liu, Yang, additional, Blaj, Cristina, additional, Knox, John, additional, Freilich, Rebecca, additional, Quintana, Elsa, additional, Cregg, Jim, additional, Bermingham, Alun, additional, Gill, Adrian L., additional, Smith, Jacqueline Am, additional, and Singh, Mallika, additional

Published
2022
Full Text
View/download PDF

23. Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut

Author

Joseph, Nancy M., He, Shenghui, Quintana, Elsa, Kim, Yun-Gi, Nunez, Gabriel, and Morrison, Sean J.

Subjects
Physiological aspects, Research, Enteric nervous system -- Physiological aspects, Neurogenesis -- Research, Digestive system -- Physiological aspects, Glia -- Physiological aspects, Digestive organs -- Physiological aspects, Intestine, Small -- Physiological aspects, Neuroglia -- Physiological aspects, Nervous system, Autonomic -- Physiological aspects
Abstract

INTRODUCTION In the 1960s Altman and Das administered tritiated thymidine to adult rats to label dividing cells and demonstrated that neurogenesis occurs in the dentate gyrus and the olfactory bulb [...], It is unclear whether neurogenesis occurs in the adult mammalian enteric nervous system (ENS). Neural crest-derived cells capable of forming multilineage colonies in culture, and neurons and glia upon transplantation into chick embryos, persist throughout adult life in the mammalian ENS. In this study we sought to determine the physiological function of these cells. We discovered that these cells could be identified based on CD49b expression and that they had characteristics of enteric glia, including p75, GFAP, S100B, and SOX10 expression. To test whether new neurons or glia arise in the adult gut under physiological conditions, we marked dividing progenitors with a thymidine analog in rodents under steady-state conditions, or during aging, pregnancy, dietary changes, hyperglycemia, or exercise. We also tested gut injuries including inflammation, irradiation, benzalkonium chloride treatment, partial gut stenosis, and glial ablation. We readily observed neurogenesis in a neurogenic region of the central nervous system, but not reproducibly in the adult ENS. Lineage tracing of glial cells with GFAP-Cre and GFAP-CreERT2 also detected little or no adult ENS neurogenesis. Neurogenesis in the adult gut is therefore very limited under the conditions we studied. In contrast, ENS gliogenesis was readily observed under steady-state conditions and after injury. Adult enteric glia thus have the potential to form neurons and glia in culture but are fated to form mainly glia under physiological conditions and after the injuries we studied.

Published
2011
Full Text
View/download PDF

25. Abstract LB050: Modulation of innate and adaptive immunity in blood and tumor of patients receiving the SHP2 inhibitor RMC-4630

Author

Chen, Ariel Yung-Chia, primary, Haura, Eric, additional, Pacheco, Jose, additional, Koczywas, Marianna, additional, Gordon, Michael, additional, Ulahannan, Susanna, additional, Burris, Howard A., additional, Ou, Sai-Hong Ignatius, additional, Wang, Judy S., additional, Riess, Jonathan W., additional, McCoach, Caroline, additional, Capasso, Anna, additional, Quintana, Elsa, additional, Hayes, Josie, additional, Dua, Richa, additional, Bitman, Bojena, additional, Guerra, Martha, additional, Wang, Hongfang, additional, Wang, Xiaolin, additional, and Janne, Pasi A., additional

Published
2021
Full Text
View/download PDF

26. Abstract 1273: Discovery of a potent, selective, and orally bioavailable SOS1 inhibitor, RMC-023, an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction

Author

Buckl, Andreas, primary, Quintana, Elsa, additional, Lee, Grace J., additional, Shifrin, Nataliya, additional, Zhong, Mengqi, additional, Garrenton, Lindsay S., additional, Montgomery, David C., additional, Stahlhut, Carlos, additional, Zhao, Frances, additional, Whalen, Dan M., additional, Thompson, Severin K., additional, Tambo-ong, Arlyn, additional, Gliedt, Micah, additional, Knox, John E., additional, Cregg, James J., additional, Aay, Naing, additional, Choi, Jong, additional, Nguyen, Bao, additional, Tripathi, Atti, additional, Zhao, Ruiping, additional, Saldajeno-Concar, Mae, additional, Marquez, Abby, additional, Hsieh, Daphne, additional, McDowell, Laura L., additional, Koltun, Elena S., additional, Bermingham, Alun, additional, Wildes, David, additional, Singh, Mallika, additional, Wang, Zhengping, additional, Hansen, Richard, additional, Smith, Jan A., additional, and Gill, Adrian L., additional

Published
2021
Full Text
View/download PDF

29. Downregulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying

Author

Calatayud, Sara, Garcia-Zaragoza, Eugenia, Hernandez, Carlos, Quintana, Elsa, Felipo, Vicente, Esplugues, Juan Vicente, and Barrachina, Maria Dolores

Subjects
Endotoxins, Nitric oxide, Biological sciences
Abstract

A single intraperitoneal injection of endotoxin (40 [micro]g/kg) significantly delayed gastric emptying of a solid nutrient meal. Blockade of nitric oxide synthase (NOS) with 30 mg/kg ip [N.sup.G]-nitro-L-arginine methyl ester or 20 mg/kg ip 7-nitroindazole [neuronal NOS (nNOS) inhibitor] significantly delayed gastric emptying in control animals but failed to modify gastric emptying in endotoxin-treated rats. Administration of 2.5, 5, and 10 mg/kg ip [N.sup.6]-iminoethyl-L-lysine [inducible NOS (iNOS) inhibitor] had no effect in either experimental group. Indomethacin (5 mg/kg sc), NS-398 (cyclooxygenase-2 inhibitor; 10 mg/kg ip), and dexamethasone (10 mg/kg sc) but not quinacrine (20 mg/kg ip) significantly prevented delay in gastric emptying induced by endotoxin but failed to modify gastric emptying in vehicle-treated animals. [Ca.sup.2+]-dependent NOS activity in the antrum pylorus of the stomach was diminished by endotoxin, whereas [Ca.sup.2+]-independent NOS activity was not changed. In addition, decreased nNOS mRNA and protein were observed in the antrum pylorus of endotoxin-treated rats. Our results suggest that downregulation of nNOS in the antrum pylorus of the stomach and synthesis of prostaglandins mediate the delay in gastric emptying of a solid nutrient meal induced by endotoxin. nitric oxide; prostaglandins; antrum pylorus; nutrient meals

Published
2002

31. List of Contributing Authors

Author

Aaronson, Stuart A., primary, Abbruzzese, James L., additional, Abel, Erika L., additional, Anderson, Kenneth C., additional, Arrick, Bradley A., additional, Bafico, Anna, additional, Barbash, Olena, additional, Bast, Robert C., additional, Baylin, Stephen B., additional, Nebiyou Bekele, B., additional, Bertino, Joseph R., additional, Boerner, Scott A., additional, Bommer, Guido T., additional, Borden, Ernest C., additional, Buchstaller, Johanna M., additional, Buetow, Kenneth H., additional, Burman, Kenneth D., additional, Calin, George Adrian, additional, Campisi, Judith, additional, Caprioli, Richard M., additional, Carroll, Peter R., additional, Chaurand, Pierre, additional, Ashley Chi, Jen-Tsan, additional, Cleveland, John L., additional, Collins, Jerry M., additional, Cortes, Jorge, additional, Costello, Joseph F., additional, Cox, James D., additional, Maria Croce, Carlo, additional, D'Andrea, Alan D., additional, Davis, Darren W., additional, Deberardinis, Ralph J., additional, Demasi, Joseph, additional, Alan Diehl, J., additional, Digiovanni, John, additional, Dorsey, Frank C., additional, Egeblad, Mikala, additional, Ekmekcioglu, Suhendan, additional, Evelhoch, Jeffrey L., additional, Fearon, Eric R., additional, Febbo, Phillip G., additional, Feng, Zhaohui, additional, Fletcher, Christopher D.M., additional, Frankel, Arthur E., additional, Friedman, David B., additional, Fury, Matthew G., additional, Gambhir, Sanjiv Sam, additional, Gazdar, Adi F., additional, Girard, Luc, additional, Glick, Adam B., additional, Maria Gonzalez-Angulo, Ana, additional, Gray, Joe W., additional, Greene, Kirsten L., additional, Grimm, Elizabeth A., additional, Grumolato, Luca, additional, Guertin, David A., additional, Hait, William N., additional, Havrda, Matthew C., additional, Hennessy, Bryan, additional, Herbst, Roy S., additional, Houghton, Alan N., additional, Houghton, Peter J., additional, Howley, Peter M., additional, Hu, Wenwei, additional, Hwu, Patrick, additional, Israel, Mark A., additional, Jacks, Tyler, additional, Jorgensen, Claus, additional, Kantarjian, Hagop, additional, Keith, Brian, additional, Kelsen, David P., additional, Michael Korn, W., additional, Kundra, Priya, additional, Kurzrock, Razelle, additional, Jack Lee, J., additional, Levine, Arnold J., additional, Li, Long-Cheng, additional, Lippman, Scott M., additional, Littlepage, Laurie E., additional, Liu, Yong-Jun, additional, Look, Thomas, additional, Lorusso, Patricia M., additional, Malkin, David, additional, Margolin, Judith, additional, Matrisian, Lynn M., additional, Mccormick, Frank, additional, Mendelsohn, John, additional, Merghoub, Taha, additional, Mills, Gordon B., additional, Minna, John D., additional, Morrison, Sean J., additional, Morton, Christopher L., additional, Neckers, Len, additional, Nevins, Joseph R., additional, Okino, Steven T., additional, Pardoll, Drew M., additional, Pawson, Tony, additional, Payne, Elspeth, additional, Pfister, David G., additional, Polsky, David, additional, Poplack, David G., additional, Posada, Juan Gonzales, additional, Powis, Garth, additional, Quintana, Elsa, additional, Quintás-Cardama, Alfonso, additional, Rabin, Karen R., additional, Reimann, Julie D.R., additional, Rubin, Eric, additional, Sabatini, David M., additional, Sato, Mitsuo, additional, Sausville, Edward A., additional, Sen, Ganes, additional, Shah, Manish A., additional, Shames, David S., additional, Shoemaker, Robert H., additional, Sikic, Branimir I., additional, Silverman, Robert H., additional, Celeste Simon, M., additional, Spellman, Paul T., additional, Steeves, Meredith A., additional, Thompson, Craig B., additional, Tonon, Giovanni, additional, Weinberg, Robert A., additional, Welch, Danny R., additional, Werb, Zena, additional, Winslow, Monte M., additional, Woodward, Wendy A., additional, Xiong, Henry Q., additional, Yaghoubi, Shahriar S., additional, and Yuspa, Stuart H., additional

Published
2008
Full Text
View/download PDF

32. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity

Author

Myers, Darienne R., primary, Abram, Clare L., additional, Wildes, David, additional, Belwafa, Amira, additional, Welsh, Alia M. N., additional, Schulze, Christopher J., additional, Choy, Tiffany J., additional, Nguyen, Tram, additional, Omaque, Neil, additional, Hu, Yongmei, additional, Singh, Mallika, additional, Hansen, Rich, additional, Goldsmith, Mark A., additional, Quintana, Elsa, additional, Smith, Jacqueline A. M., additional, and Lowell, Clifford A., additional

Published
2020
Full Text
View/download PDF

33. Abstract 2837: Dual inhibition of SHP2 and CDK4/6 leads to immunological memory and immune-mediated anti-tumor activity in a mouse syngeneic model of breast cancer

Author

Shifrin, Nataliya Tovbis, primary, Lee, Grace J., additional, Omaque, Neil, additional, Nguyen, Tram, additional, Belwafa, Amira, additional, Lorenzana, Edward G., additional, Nichols, Robert J., additional, Smith, Jacqueline A., additional, Singh, Mallika, additional, and Quintana, Elsa, additional

Published
2020
Full Text
View/download PDF

34. Allosteric Inhibition of SHP2 Stimulates Antitumor Immunity by Transforming the Immunosuppressive Environment

Author

Quintana, Elsa, primary, Schulze, Christopher J., additional, Myers, Darienne R., additional, Choy, Tiffany J., additional, Mordec, Kasia, additional, Wildes, David, additional, Shifrin, Nataliya Tobvis, additional, Belwafa, Amira, additional, Koltun, Elena S., additional, Gill, Adrian L., additional, Singh, Mallika, additional, Kelsey, Stephen, additional, Goldsmith, Mark A., additional, Nichols, Robert, additional, and Smith, Jacqueline A.M., additional

Published
2020
Full Text
View/download PDF

38. Abstract A103: Allosteric inhibition of SHP2 induces antitumor immunity in PD-1-sensitive tumors through modulation of both innate and adaptive mechanisms

Author

Quintana, Elsa, primary, Mordec, Kasia, additional, Nichols, Robert J., additional, Wildes, David, additional, Schulze, Chris J., additional, Myers, Darienne R., additional, Singh, Mallika, additional, Koltun, Elena, additional, Gill, Adrian, additional, Kelsey, Stephen, additional, Goldsmith, Mark A, additional, and Smith, Jan A.M., additional

Published
2019
Full Text
View/download PDF

40. Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma

Author

Eskiocak, Ugur, primary, Ramesh, Vijayashree, additional, Gill, Jennifer G., additional, Zhao, Zhiyu, additional, Yuan, Stacy W., additional, Wang, Meng, additional, Vandergriff, Travis, additional, Shackleton, Mark, additional, Quintana, Elsa, additional, Frankel, Arthur E., additional, Johnson, Timothy M., additional, DeBerardinis, Ralph J., additional, and Morrison, Sean J., additional

Published
2016
Full Text
View/download PDF

44. Orientaciones Didácticas y Guía de Recursos del Area de Música

Author

Chavarría Hernández, Teresa, Verdú Quintana, Elsa Guadalupe, Sanz Arribas, Jesús, Gobierno de Canarias. Dirección General de Ordenación e Innovación Educativa, Calle José Antonio de Zárate y Penichet, 4. Edificio Arco Iris. Urbanización Anaga, 38001 Santa Cruz de Tenerife, 922-60.17.61, and 922-60.17.46

Subjects
Islas Canarias, enseñanza secundaria, orientación pedagógica, educación musical, música, lección
Abstract

Este cuadernillo recoge aspectos del currículo, tales como: desarrollo de los objetivos, la metodología utilizada, aspectos de la evaluación, etc. Asimismo, la aporta una unidad didáctica sobre Los Cantos Canarios de Tebaldo Power, ilustrando de esta forma, la manera de llevar a la práctica el currículo del área de Música. Igualmente, se incluye un Guía de Recursos del Area, con unapéndice bibliográfico y otros recursos didácticos, lo que hace que este trabajo sea una información útil para el profesorado, que puede enriquecer, ampliar y contemplar su tarea docente en el aula. Canarias ESP

Published
1995

45. Cuadernos para la coeducación 9. Música, Educación Plástica y Visual. Etapa Secundaria

Author

Bolaños Espinosa, María del Carmen, González Díaz, María Dolores, Jiménez Suárez, Manuel, Vega Suárez, Teresa, Chavarría Hernández, Teresa, Verdú Quintana, Elsa Guadalupe, Bolaños Espinosa, María del Carmen, CEP de La Laguna (Tenerife). Asesoría de Coeducación, and Gobierno de Canarias. Dirección General de Ordenación e Innovación Educativa. Programa Harimaguada

Subjects
enseñanza secundaria, coeducación, educación musical, diferencia de sexo, igualdad de oportunidades, música, ESO, educación cívica, educación artística
Abstract

Se enmarca dentro del Programa Harimaguada de Educación Afectivo-Sexual de la Consejería de Educación, Cultura y Deportes del Gobierno de Canarias Este cuadernillo para la coeducación presenta algunos elementos de análisis, justificación y práctica educativa relativos a la esta secundaria y al área de música, educación plástica y visual. La finalidad es, ir avanzado en la construcción de centros educativos promotores de la igualdad de oportunidades para ambos sexos. El proceso que sigue es: reflexionar, justificar por qué y por dónde emprender la labor coeducativa y plantear actividades ejemplificadoras que ilustren el comienzo de esta tarea desde una metodología participativa, comprensiva y comprometida con la mejora del centro y del entorno. Canarias ESP

Published
1994

Catalog

Books, media, physical & digital resources
See catalog results