Search

Ever since the introduction of insulin in the treatment of diabetes mellitus by Banting and Best, extensive studies have been made to determine the exact mode of action of insulin. Insulin lowers the blood sugar and stimulates the formation of glycogen in the liver. Recently, Price, Cori and Colowick1 have found one fundamental function of insulin. They have demonstrated that the action of the enzyme hexokinase, which with adenosine triphosphate converts glucose to glucose-6-phosphate, may be inhibited in vivo or in vitro by anterior pituitary N. F.and that this inhibition can be countracted by insulin.In contrast to the action of insulin, anterior pituitary results in hyperglycemia and glycosuria. Another antagonist to insulin in the maintenance of the blood sugar level is epinephrine, which increases the blood sugar by mobilizing sugar from glycogen. When insulin is given in excess, changes in distribution of lipids and loss of chromaffin substance

The common association of sinusitis and bronchiectasis has been noted repeatedly in the past decade; the literature is mainly distributed in the journals of otolaryngology. Despite this fact, it is not yet well enough known that some patients with symptoms suggesting pulmonary tuberculosis but with repeatedly negative sputums may have bronchiectasis, usually associated with chronic infection of the upper respiratory tract. Far too often these patients are treated for long periods in sanatoriums for tuberculous patients. Within the past year two patients have been observed who spent six and eight years, respectively, receiving treatment for tuberculosis; both had fairly advanced bilateral bronchiestasis with pansinusitis. In one of these cases the patient denied that any investigation of the sinuses had been carried out during the period of years at the sanatorium.The French were among the first to recognize the common occurrence of chronic pulmonary infection in association