14 results on '"Quinn, E.M."'
Search Results
2. A comparative analysis of breast cancer affecting young versus older women
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Shaffiq Izzad, N.E.C., primary, O'leary, P., additional, Quinn, E.M., additional, Butt, A., additional, Livingstone, V., additional, Redmond, H.P., additional, and Corrigan, M., additional
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- 2018
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3. The information needs of patients with breast cancer at years one, three and five post diagnosis
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Sheehy, E.M., primary, Lehane, E.A., additional, Quinn, E.M., additional, Livingstone, V., additional, Redmond, H.P., additional, and Corrigan, M.A., additional
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- 2018
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4. 190 (PB-091) - A comparative analysis of breast cancer affecting young versus older women
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Shaffiq Izzad, N.E.C., O'leary, P., Quinn, E.M., Butt, A., Livingstone, V., Redmond, H.P., and Corrigan, M.
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- 2018
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- View/download PDF
5. 122 (PB-023) - The information needs of patients with breast cancer at years one, three and five post diagnosis
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Sheehy, E.M., Lehane, E.A., Quinn, E.M., Livingstone, V., Redmond, H.P., and Corrigan, M.A.
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- 2018
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6. Identification of risk loci with shared effects on five major psychiatric disorders:a genome-wide analysis
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Smoller, J.W., Ripke, S., Lee, P.H., Neale, B., Nurnberger, J.I., Santangelo, S., Sullivan, P.F., Perlis, R.H., Purcell, S.M., Fanous, A., Neale, M.C., Rietschel, M., Schulze, T.G., Thapar, A., Anney, R., Buitelaar, J.K., Farone, S.V., Hoogendijk, W.J.G., Levinson, D.F., Lesch, K.P., Riley, B., Schachar, R., Sonuga-Barke, E.J., Absher, D., Agartz, I., Akil, H., Amin, F., Andreassen, O.A., Anjorin, A., Arking, D., Asherson, P., Azevedo, M.H., Backlund, L., Badner, J.A., Banaschewski, T., Barchas, J.D., Barnes, M.R., Bass, N., Bauer, M.C.R., Bellivier, F., Bergen, S.E., Berrettini, W., Bettecken, T., Biederman, J, Binder, E.B., Black, D.W., Blackwood, D.H., Bloss, C.S., Boehnke, M., Boomsma, D.I., Breen, G., Breuer, R., Buccola, N.G., Bunner, W.E., Burmeister, M., Buxbaum, J.D., Byerley, W. F., Sian, C., Cantor, R.M., Chakravarti, A., Chambert, K., Chicon, S., Cloniger, C.R., Collier, D.A., Cook, E., Coon, H., Corvin, A., Coryell, W.H., Craig, D.W., Craig, I.W., Curtis, D., Czamara, D., Daly, M., Datta, S., Day, R., de Geus, E.J.C., Degenhardt, F., Devlin, B., Srdjan, D., Doyle, A.E., Duan, J., Dudbridge, F., Edenberg, H.J., Elkin, A., Etain, B., Farmer, A.E., Ferreira, M.A.R., Ferrier, I.N., Flickinger, M., Foroud, T., Frank, J., Franke, B., Fraser, C., Freedman, R., Freimer, N.B., Friedl, M., Frisén, L., Gejman, P.V., Georgieva, L., Gershon, E.S., Giegling, I., Gill, M., Gordon, S.D., Gordon-Smith, K., Green, E.K., Greenwood, T.A., Gross, M., Grozeva, D., Guan, W., Gurling, H., Gustafsson, O., Hakonarson, H., Hamilton, S.P., Hamshere, M.L., Hansen, T.F., Hartmann, A.M., Hautzinger, M., Heath, A.C., Henders, A.K., Herms, S., Hickie, I.B., Hipolito, M., Hoefels, S., Holmans, P.A., Holsboer, F., Hottenga, J.J., Hultman, C. M., Ingason, A., Ising, M., Jamain, S., Jones, E.G., Jones, L., Jones, I., Jung-Ying, T., Kahler, A., Kandaswamy, R., Keller, M.C., Kelsoe, J., Kennedy, J.L., Kenny, E., Kim, Y., Kirov, G. K., Knowles, J.A., Kohli, M.A., Koller, D.L., Konte, B., Korszun, A., Krasucki, R., Kuntsi, J., Phoenix, K., Landén, M., Langstrom, N., Lathrop, M., Lawrence, J., Lawson, W.B., Leboyer, M., Lencz, T., Lewis, C.M., Li, J., Lichtenstein, P., Lieberman, J. A., Lin, D., Liu, C., Lohoff, F.W., Loo, S.K., Lucae, S., MacIntyre, D.J., Madden, P.A.F., Magnusson, P., Mahon, P.B., Maier, W., Malhotra, A.K., Mattheisen, M., Matthews, K., Mattingsdal, M., McCarroll, S., McGhee, K.A., McGough, J.J., McGrath, P.J., McGuffin, P., McInnis, M.G., McIntosh, A., McKinney, R., McClean, A.W., McMahon, F.J., McQuillin, A., Medeiros, H., Medland, S.E., Meier, S., Melle, I., Meng, F., Middeldorp, C.M., Middleton, L., Vihra, M., Mitchell, P.B., Montgomery, G.W., Moran, J., Morken, G., Morris, D.W., Moskvina, V., Mowry, B. J., Muglia, P., Mühleisen, T.W., Muir, W.J., Müller-Myhsok, B., Myers, R.M., Nelson, S.F., Nievergelt, C.M., Nikolovq, I., Nimgaonkar, V.L., Nolen, W.A., Nöthen, M.M., Nwulia, E.A., Nyholt, DR, O'Donovan, M.C., O'Dushlaine, C., Oades, R.D., Olincy, A., Olsen, L., Ophoff, R.A., Osby, U., Óskarsson, H., Owen, M.J., Palotie, A., Pato, M.T., Pato, C.N., Penninx, B.W.J.H., Pergadia, M.L., Petursson, H., Pickard, B.S., Pimm, J., Piven, J., Porgeirsson, P., Posthuma, D., Potash, J.B., Propping, J., Puri, V., Quested, D., Quinn, E.M., Rasmussen, H.B., Raychaudhuri, S., Rehnström, K., Reif, A., Rice, J., Rossin, L., Rothenberger, A., Rouleau, G., Ruderfer, D., Rujescu, D., Sanders, A.R., Schalling, M., Schatzberg, A.F., Scheftner, W.A., Schellenberg, G.D., Schofield, P.R., Schork, N.J., Schumacher, J., Schwarz, M.M., Scolnick, E., Scott, L.J., Shi, J., Shillling, P.D., Shyn, S.I., Sigurdsson, E., Silverman, J.M., Sklar, P., Slager, S.L., Smalley, S.L., Smit, J.H., Smith, E.N., Sonuga-Barke, E., St Clair, D., State, M., Stefansson, K., Stefansson, H., Steffans, M., Steinberg, S., Steinhausen, H.C., Strauss, J., Strohmaier, J., Stroup, T.S., Sutcliffe, J., Szatmari, P., Szelinger, S., Thirumalai, S., Thompson, R.C., Tozzi, F., Treutlein, J., Uhr, M., van den Oord, E.J., Grootheest, G., Vieland, V., Vincent, J.B., Visscher, P.M., Watson, S.J., Weissman, M.M., Werge, T., Wienker, T.F., Willemsen, G., Williamson, R., Witt, S.H., Wray, N.R., Wright, A., Xu, W., Young, A.H., Zammit, S., Zandi, P.P., Zhang, P., Zitman, F.G., Zöllner, S., Kendler, K.S., Psychiatry, Human genetics, Epidemiology and Data Science, NCA - Brain mechanisms in health and disease, NCA - Neurobiology of mental health, EMGO - Mental health, NCA - Brain imaging technology, Biological Psychology, Functional Genomics, Neuroscience Campus Amsterdam - Brain Mechanisms in Health & Disease, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, EMGO+ - Mental Health, Neuroscience Campus Amsterdam - Brain Imaging Technology, Psychiatrie & Neuropsychologie, Farmacologie en Toxicologie, RS: CARIM School for Cardiovascular Diseases, RS: MHeNs School for Mental Health and Neuroscience, Oades, Robert D. (Beitragende*r), and Oades, Robert D.
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Netherlands Twin Register (NTR) ,Adult ,medicine.medical_specialty ,Bipolar Disorder ,Calcium Channels, L-Type ,Population ,Medizin ,Genome-wide association study ,Biology ,Polymorphism, Single Nucleotide ,Article ,Genomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory [IGMD 3] ,medicine ,ddc:61 ,Attention deficit hyperactivity disorder ,Humans ,DCN PAC - Perception action and control NCEBP 9 - Mental health ,ddc:610 ,Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters ,Bipolar disorder ,Age of Onset ,Psychiatry ,education ,Child ,Genetics ,education.field_of_study ,Depressive Disorder, Major ,General Medicine ,Genomic disorders and inherited multi-system disorders [DCN PAC - Perception action and control IGMD 3] ,medicine.disease ,Logistic Models ,Autism spectrum disorder ,Schizophrenia ,Attention Deficit Disorder with Hyperactivity ,Child Development Disorders, Pervasive ,Genetic Loci ,Expression quantitative trait loci ,Major depressive disorder ,Genome-Wide Association Study - Abstract
Item does not contain fulltext BACKGROUND: Findings from family and twin studies suggest that genetic contributions to psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to identify specific variants underlying genetic effects shared between the five disorders in the Psychiatric Genomics Consortium: autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia. METHODS: We analysed genome-wide single-nucleotide polymorphism (SNP) data for the five disorders in 33,332 cases and 27,888 controls of European ancestory. To characterise allelic effects on each disorder, we applied a multinomial logistic regression procedure with model selection to identify the best-fitting model of relations between genotype and phenotype. We examined cross-disorder effects of genome-wide significant loci previously identified for bipolar disorder and schizophrenia, and used polygenic risk-score analysis to examine such effects from a broader set of common variants. We undertook pathway analyses to establish the biological associations underlying genetic overlap for the five disorders. We used enrichment analysis of expression quantitative trait loci (eQTL) data to assess whether SNPs with cross-disorder association were enriched for regulatory SNPs in post-mortem brain-tissue samples. FINDINGS: SNPs at four loci surpassed the cutoff for genome-wide significance (p
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- 2013
7. Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder
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Williams, H.J., Norton, N., Dwyer, S., Moskvina, V., Nikolov, I., Carroll, L., Georgieva, L., Williams, N.M., Morris, D.W., Quinn, E.M., Giegling, I., Ikeda, M., Wood, J., Lencz, T., Hultman, C., Lichtenstein, P., Thiselton, D., Maher, B.S., Malhotra, A.K., Riley, B., Kendler, K.S., Gill, M., Sullivan, P., Sklar, P., Purcell, S., Nimgaonkar, V.L., Kirov, G., Holmans, P., Corvin, A., Rujescu, D., Craddock, N., Owen, M.J., O'Donovan, M.C., GROUP investigators, [No Value], and Science in Healthy Ageing & healthcaRE (SHARE)
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mental disorders - Abstract
A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P = 1.61 x 10(-7)), and stronger evidence when the phenotype was broadened to include bipolar disorder (P = 9.96 x 10(-9)). In this study we provide additional evidence for association through meta-analysis of a larger data set (schizophrenia/schizoaffective disorder N = 18 945, schizophrenia plus bipolar disorder N = 21 274 and controls N = 38 675). We also sought to better localize the association signal using a combination of de novo polymorphism discovery in exons, pooled de novo polymorphism discovery spanning the genomic sequence of the locus and high-density linkage disequilibrium (LD) mapping. The meta-analysis provided evidence for association between rs1344706 that surpasses widely accepted benchmarks of significance by several orders of magnitude for both schizophrenia (P = 2.5 x 10(-11), odds ratio (OR) 1.10, 95% confidence interval 1.07-1.14) and schizophrenia and bipolar disorder combined (P = 4.1 x 10(-13), OR 1.11, 95% confidence interval 1.07-1.14). After de novo polymorphism discovery and detailed association analysis, rs1344706 remained the most strongly associated marker in the gene. The allelic association at the ZNF804A locus is now one of the most compelling in schizophrenia to date, and supports the accumulating data suggesting overlapping genetic risk between schizophrenia and bipolar disorder. Molecular Psychiatry (2011) 16, 429-441; doi:10.1038/mp.2010.36; published online 6 April 2010
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- 2011
8. Genome-wide association study identifies five new schizophrenia loci
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Ripke, S. Sanders, A.R. Kendler, K.S. Levinson, D.F. Sklar, P. Holmans, P.A. Lin, D.-Y. Duan, J. Ophoff, R.A. Andreassen, O.A. Scolnick, E. Cichon, S. St. Clair, D. Corvin, A. Gurling, H. Werge, T. Rujescu, D. Blackwood, D.H.R. Pato, C.N. Malhotra, A.K. Purcell, S. Dudbridge, F. Neale, B.M. Rossin, L. Visscher, P.M. Posthuma, D. Ruderfer, D.M. Fanous, A. Stefansson, H. Steinberg, S. Mowry, B.J. Golimbet, V. De Hert, M. Jönsson, E.G. Bitter, I. Pietiläinen, O.P.H. Collier, D.A. Tosato, S. Agartz, I. Albus, M. Alexander, M. Amdur, R.L. Amin, F. Bass, N. Bergen, S.E. Black, D.W. Børglum, A.D. Brown, M.A. Bruggeman, R. Buccola, N.G. Byerley, W.F. Cahn, W. Cantor, R.M. Carr, V.J. Catts, S.V. Choudhury, K. Cloninger, C.R. Cormican, P. Craddock, N. Danoy, P.A. Datta, S. De Haan, L. Demontis, D. Dikeos, D. Djurovic, S. Donnelly, P. Donohoe, G. Duong, L. Dwyer, S. Fink-Jensen, A. Freedman, R. Freimer, N.B. Friedl, M. Georgieva, L. Giegling, I. Gill, M. Glenthøj, B. Godard, S. Hamshere, M. Hansen, M. Hansen, T. Hartmann, A.M. Henskens, F.A. Hougaard, D.M. Hultman, C.M. Ingason, A. Jablensky, A.V. Jakobsen, K.D. Jay, M. Jürgens, G. Kahn, R.S. Keller, M.C. Kenis, G. Kenny, E. Kim, Y. Kirov, G.K. Konnerth, H. Konte, B. Krabbendam, L. Krasucki, R. Lasseter, V.K. Laurent, C. Lawrence, J. Lencz, T. Lerer, F.B. Liang, K.-Y. Lichtenstein, P. Lieberman, J.A. Linszen, D.H. Lönnqvist, J. Loughland, C.M. MacLean, A.W. Maher, B.S. Maier, W. Mallet, J. Malloy, P. Mattheisen, M. Mattingsdal, M. McGhee, K.A. McGrath, J.J. McIntosh, A. McLean, D.E. McQuillin, A. Melle, I. Michie, P.T. Milanova, V. Morris, D.W. Mors, O. Mortensen, P.B. Moskvina, V. Muglia, P. Myin-Germeys, I. Nertney, D.A. Nestadt, G. Nielsen, J. Nikolov, I. Nordentoft, M. Norton, N. Nöthen, M.M. O'Dushlaine, C.T. Olincy, A. Olsen, L. O'Neill, F.A. Ørntoft, T.F. Owen, M.J. Pantelis, C. Papadimitriou, G. Pato, M.T. Peltonen, L. Petursson, H. Pickard, B. Pimm, J. Pulver, A.E. Puri, V. Quested, D. Quinn, E.M. Rasmussen, H.B. Réthelyi, J.M. Ribble, R. Rietschel, M. Riley, B.P. Ruggeri, M. Schall, U. Schulze, T.G. Schwab, S.G. Scott, R.J. Shi, J. Sigurdsson, E. Silverman, J.M. Spencer, C.C.A. Stefansson, K. Strange, A. Strengman, E. Stroup, T.S. Suvisaari, J. Terenius, L. Thirumalai, S. Thygesen, J.H. Timm, S. Toncheva, D. Van Den Oord, E. Van Os, J. Van Winkel, R. Veldink, J. Walsh, D. Wang, A.G. Wiersma, D. Wildenauer, D.B. Williams, H.J. Williams, N.M. Wormley, B. Zammit, S. Sullivan, P.F. O'Donovan, M.C. Daly, M.J. Gejman, P.V.
- Abstract
We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 × 10 -11) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10 -9), ANK3 (rs10994359, P = 2.5 × 10 -8) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10 -9). © 2011 Nature America, Inc. All rights reserved.
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- 2011
9. Abdominal Aortic Aneurysm Repair in the Presence of a Stoma
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Galbraith, A.S., primary, Quinn, E.M., additional, McMonagle, M.P., additional, and Cross, K.S., additional
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- 2015
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10. Fine mapping of ZNF804A and genome wide significant evidence for its involvement in schizophrenia and bipolar disorder
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Williams, H.J., Norton, N., Dwyer, S., Moskivina, V., Nikolov, I., Carroll, L., Georgieva, L., Williams, N.M., Morris, D.W., Quinn, E.M., Giegling, I., Ikeda, M., Wood, J., Lencz, T., Hultman, C., Lichtenstein, P., Thiselton, D., Mahler, B.S., Bruggeman, R., Cahn, W., de Haan, L., Kahn, R., Krabbendam, L., Linzen, D., Myin-Germeys, I., van Os, J, Wiersma, D., Malhotra, A.K., Riley, B., Kendler, K.S., Gill, M., Sklar, P., Purcell, S., Nimgaonkar, V.L., Kirov, G., Holmans, P., Corvin, A., Rujescu, D., Craddock, N., Educational Neuroscience, Clinical Child and Family Studies, LEARN! - Brain, learning and development, ANS - Amsterdam Neuroscience, Adult Psychiatry, Psychiatrie & Neuropsychologie, and RS: MHeNs School for Mental Health and Neuroscience
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Adult ,Male ,Linkage disequilibrium ,Bipolar Disorder ,Genotype ,Quantitative Trait Loci ,Kruppel-Like Transcription Factors ,Schizoaffective disorder ,Genome-wide association study ,Locus (genetics) ,Bioinformatics ,Polymorphism, Single Nucleotide ,Article ,Linkage Disequilibrium ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Gene Frequency ,Meta-Analysis as Topic ,mental disorders ,medicine ,Odds Ratio ,Humans ,Genetic Predisposition to Disease ,Bipolar disorder ,Allele ,Molecular Biology ,030304 developmental biology ,Genetic association ,Aged ,Genetics ,0303 health sciences ,biology ,association ,Chromosome Mapping ,Exons ,Middle Aged ,medicine.disease ,meta-analysis ,Europe ,Psychiatry and Mental health ,biology.protein ,Schizophrenia ,Female ,030217 neurology & neurosurgery ,Zinc finger protein 804A ,ZNF804A ,Genome-Wide Association Study - Abstract
A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 ? 10(-7)), and stronger evidence when the phenotype was broadened to include bipolar disorder (P=9.96 ? 10(-9)). In this study we provide additional evidence for association through meta-analysis of a larger data set (schizophrenia/schizoaffective disorder N=18?945, schizophrenia plus bipolar disorder N=21?274 and controls N=38?675). We also sought to better localize the association signal using a combination of de novo polymorphism discovery in exons, pooled de novo polymorphism discovery spanning the genomic sequence of the locus and high-density linkage disequilibrium (LD) mapping. The meta-analysis provided evidence for association between rs1344706 that surpasses widely accepted benchmarks of significance by several orders of magnitude for both schizophrenia (P=2.5 ? 10(-11), odds ratio (OR) 1.10, 95% confidence interval 1.07-1.14) and schizophrenia and bipolar disorder combined (P=4.1 ? 10(-13), OR 1.11, 95% confidence interval 1.07-1.14). After de novo polymorphism discovery and detailed association analysis, rs1344706 remained the most strongly associated marker in the gene. The allelic association at the ZNF804A locus is now one of the most compelling in schizophrenia to date, and supports the accumulating data suggesting overlapping genetic risk between schizophrenia and bipolar disorder.
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- 2010
11. Routine calcium measurement is not necessary after most thyroid surgeries: a prospective clinical study
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Quinn, E.M., primary, Neary, P.M., additional, O’Connor, O.J., additional, Shafiq, A., additional, Kelly, J., additional, and Redmond, H.P., additional
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- 2010
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12. Report Survey Can Save Computer Costs
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Quinn, E.M.
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Computers ,Business ,Health care industry - Published
- 1983
13. Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
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Nepogodiev, D., Matthews, J. H., Morley, G. L., Naumann, D. N., Ball, A., Chauhan, P., Bhanderi, S., Mohamed, I., Glasbey, J. C., Wilkin, R. J. W., Drake, T. M., Clements, J., Blencowe, N. S., Herrod, P. J. J., Pata, F., Frasson, M., Blanco-Colino, R., Soares, A. S., Nepogodiev D, Bhangu A., Matthews, Jh, Morley, Gl, Naumann, Dn, Ball, A, Chauhan, P, Bhanderi, S, Mohamed, I, Glasbey, Jc, Wilkin, R, Drake, Tm, Clements, J, Blencowe, Ns, Herrod, P, Pata, F, Frasson, M, Blanco-Colino, R, Soares, As, Bhangu, A, Nepogodiev, D, Jain, S, Amuthalingam, T, Tyler, R, Griffiths, Ea, Pinkney, Td, Gee, O, Morton, Dg, Beggs, A, Beral, D, Bowley, D, Cruickshank, N, Daniels, I, Griffiths, E, Hornby, St, Lund, Jn, Marriott, P, Singh, P, Smart, Nj, Speake, D, Thompson, C, Torkington, J, Torrance, A, Vohra, R, Warren, O, Winter, Dc, Pellino, G, Sgrò, A, Simioni, A, Farina, V, Podda, M, Di Saverio, S, Birindelli, A, Pasquali, S, Itsurg, Surg, Pt, Bolton, W, Bradshaw, Cj, Chean, Cs, Harris, G, Haddow, Jb, Jamieson, Nb, Mccain, S, Mason, J, Milgrom, D, Nana, Gr, Mohamed, Mn, Brien, Jo, Pearce, J, Rabie, M, Sahnan, K, Sarmah, P, Skerritt, C, Ghazanfar, Ma, Sreedharan, L, Kabwama, S, Gray, Rt, Kamande, Iw, Nazarian, S, Dar, Fa, Misky, At, Arunachalam, S, Twum-Barima, Cs, Mohamed, Im, Connor, Kl, Coe, Po, Kosti, A, Elshaer, M, Colvin, Da, Charalambous, Mp, Yeung, K, Merker, L, Morrison, T, Thaventhiran, Aj, Gilbert, Tm, Clements, Jm, Hicks, G, Afshar, S, Mckinley, Nc, Assaf, N, Hanna, T, Macinnes, E, Thavanesan, N, Dubois, As, Palani-Velu, Lk, Tezas, S, Yow, L, Radwan, Rw, Abdelrahman, M, Lee, Ka, Zarka, Za, Mcdowall, Na, Tan, Cy, Venn, Ml, Ashmore, Dl, Whitehorn, Se, Golder, Am, Reddy, A, Delimpalta, C, Kay, Oh, Shah, Sm, Eiben, I, Doyle, C, Tudyka, V, Issa, E, West, H, Brewer, Hk, Farrow, Ez, Taylor, Ns, Smart, Cj, Griffiths, Np, Halkias, C, Vitish-Sharma, P, Knight, Sr, Mowbray, Ng, Olivier, Jb, Lee, Kj, Clement, Kd, Chrastek, D, Panda, N, Connor, Mj, Fahmy, Se, Bryan, Es, Ngu, Ws, Adegbola, So, Vaughan, Em, Stupalkowska, W, Simmonds, L, Malik, A, Hussein, A, Karim, Mj, Singhal, T, Ormiston, R, Kung, V, Rabie, Ma, Park, Jh, Lal, N, Worku, D, D'Auria, M, Ang, A, Orizu, M, Gammeri, E, Clough, E, Choy, Ch, Lawday, S, Hann, Aj, Robinson, D, Wardle, Bg, Mcdonnell, D, Rutherford, Dg, Hickey, Lm, Garg, Ag, Rezvani, S, Bell, Cr, Mahmood, F, Rehman, S, Donaldson, G, Peleki, A, Pearce, L, Sharp, Ol, Singh, S, Thompson, Db, El-Tayar, O, Hollyman, M, Rupasinghe, Sn, Toomey, Db, Murray, Mp, Amtul, N, Mersh, Rj, Newton, Rc, Al-Khyatt, W, Stephens, Gf, Abbas, Sh, Iqbal, Mr, Brown, Ce, Renshaw, S, Hureibi, Ka, Pullabatla-Venkata, Up, Donohoe, No, Myatt, A, Egan, Rj, Rangarajan, K, Trail, M, Mckay, Sc, Engall, N, Jerome, E, Townsend, Dc, Patel, By, Pronin, S, Chandratreya, N, Choong, Jh, Mohamed, Tm, Hudson-Peacock, Nj, Manson, R, Hebbar, K, Mothe, Bs, Weegenaar, Cr, Saad, M, Bowman, Cr, Serventi, F, Fleres, F, Foppa, C, Pata, G, Baronio, G, Pertile, D, Lucchi, A, Sagnotta, A, Maretto, I, Campagnaro, T, Gatti, M, Gjoni, E, Roscio, F, Inama, M, Coccolini, F, Colombo, F, Avanzolini, A, Aresu, S, De-Manzoni-Garberini, A, Merlini, Da, Chessa, A, Tamini, N, Mulas, S, Cillara, N, Coletta, D, Atzeni, J, Erdas, E, Gallo, G, Francone, E, Di Gioia, P, Bianchi, Cl, Ferrara, F, Biancafarina, A, Scabini, S, Marano, L, Miegge, A, Sasia, D, Savino, G, Scatizzi, M, D'Amico, Fe, Arcuri, Ga, Gavagna, L, Salamone, G, Tatulli, F, Goldin, E, Matos, Ml, Caldeira, Ab, Romano, J, Pereira, J, Azevedo, J, Azevedo, Jm, Simoes, J, Silva, A, O'Leary, Dp, Kennedy, Nd, Quinn, Em, Zhang, Ay, Neary, Pm, De-Marchi, Ja, O'Connor, Br, Wijesundera, K, Foley, Nm, Wong, J, Tiedt, La, Bolger, Jc, Connelly, Tm, Ahmed, Os, Vigorita, V, García, V, Arredondo, J, Redondo, E, Sainz, B, Aldrey, I, Landaluce-Olavarria, A, Gómez, Aa, Cordoba, E, Sánchez-Fuentes, Mn, Cerdán-Santacruz, C, Beltran-De-Heredia, J, García, M, Veres, T, García-Novoa, A, Abellán, Am, García-Catalá, L, Ruiz-Marín, M, Menendez, P, Roldán-Ortiz, S, Navas-Cuéllar, Ja, Sabia, D, Gomez-Rosado, Jc, Navidad, Ms, Caula, C, Sanchez, Er, Espin-Basany, E, Fernández-Martínez, D, Bravo-Gutiérrez, Af, Payá-Llorente, C, Dujovne, P, Lima, F, Soria-Aledo, V, Gomez, Cj, Pascual-Miguelañez, I, Muinelo, M, Alvarez, Cm, Vargas-Pierola, Hj, Vallve-Bernal, M, Hidalgo-Rosas, Jm, Arenal-Vera, Jj, Sena-Ruiz, F, Sanchez-Guillen, L, Villarejo-Campos, P, Tallon-Aguilar, L, Garcea, A, Bennett, Jm, Whittaker, L, Gidwani, Al, Byrnes, Ck, Saunders, S, Shiwani, Mh, Ashraf, N, Venkatasubramaniam, Ak, Bevan, Ke, Mcarthur, D, Mustafa, Ak, Griffith, Jp, Blazeby, Jm, Charalabopoulos, A, Campbell, W, Reese, G, Warren, Oj, Peacock, M, Menzies, D, Jenner, D, Eardley, Nj, Yoong, S, Abulafi, M, Avalapati, H, Thompson, R, Nastro, P, Kochupapy, R, Stubbs, Bm, Mcintyre, R, Crozier, J, Patel, Pk, Pento, V, Beasley, Wd, Roxburgh, C, Youssef, H, Alexander, R, Denley, S, Di Franco, F, Quddus, A, Saha, A, Hunter, I, Hannay, J, Velchuru, Vr, Bond-Smith, G, Salama, Y, Bhargava, A, Panagiotopoulos, Sp, Watson, N, Garcea, G, Boddy, Ap, Dunning, Pg, Lloyd, G, Gurjar, Sv, Hill, J, Andrews, B, Singh, A, Ruzvidzo, F, Shingler, G, Mahon, D, Elgaddal, S, Payne, Cj, Shaikh, Ia, Dalmia, S, Nair, Ms, Finch, Jg, Chapple, Ks, Bawa, S, Watfah, J, Carden, Ca, Makhija, R, Rao, M, Sarveswaran, J, Vijay, V, Rekhraj, S, Knight, B, Siddiqui, Mn, Sebastian, Jf, Glen, P, Vakis, S, Ebied, H, Rajaram, R, Gray, J, Mcgrath, D, Faulkner, G, Gopalswamy, S, Varcada, M, Woodward, A, Williams, Gl, Szentpali, K, Ravindran, R, Bronder, C, Thaha, Ma, Rate, A, Shetty, Vd, Rao, V, Sajid, Ms, Clements, B, Patel, Rt, Mason, C, Branagan, G, Maude, K, Kaur, G, Lyons, A, Ainsworth, P, Hagger, R, Zadi, Az, Maslekar, Su, Kinross, J, Irukulla, S, Hawkins, W, Wheatstone, S, Magro, T, Bailey, S, Marshall, G, Mccullough, J, Marangoni, G, Leung, El, Borg, Cm, Gopinath, S, Kirkby-Bott, J, Yalamarthi, S, Mirza, S, Brett, M, Ramcharan, S, Pandey, V, Thava, B, Andreani, Sm, Sahay, Sj, Aravind, B, Downey, M, Nicol, D, Whitehouse, P, Sharma, A, Francis, N, Chitsabesan, P, Stewart, Dj, Norcia, Gg, Cucinotta, E, Cianchi, F, Romario, Uf, Taglietti, L, Capelli, P, Garulli, G, Parisi, A, Nitti, D, Guglielmi, A, Alonzo, A, Scandroglio, Is, Moretto, G, Ansaloni, L, Pietrabissa, A, Foschi, D, Vettoretto, N, Ercolani, G, Coppola, M, Colangelo, E, Morandi, E, Niolu, P, Pala, M, Coletti, M, Pisanu, A, Nicolosi, A, Sammarco, G, Berti, S, Soliani, P, Tonini, V, Stella, M, Ceccarelli, G, De Nisco, C, Castagnoli, G, De Nardi, P, Borghi, F, Agresta, F, Benevento, A, Cantafio, S, Cesari, Mc, Rubbini, M, Chetta, G, De Marchi, F, Nora, Mf, Sousa, Hs, Nascimento, Ca, Casimiro, C, Costa, Sd, Rosa, Mj, Carvalho, N, Correia, J, Gomes, Ap, Hill, Ad, Walsh, Tn, Aremu, Ma, Mulsow, J, El-Masry, S, Gillick, J, Garvin, J, Caldwell, M, Mehigan, B, Peirce, Cb, Cooke, F, Mealy, K, Ruano, A, Ais, G, Fueyo, J, Parajó, Ae, Bernal-Sprekelsen, Jc, Monzón-Abad, Ja, Blanco, F, Arroyo, A, Bazán-Hinojo, Mc, Ramos-Bernado, Mi, Lopez-Ruiz, Ja, Golda, T, Julià, D, Cuadrado, Mm, Gómez-Abril, Sa, Martinez, J, Aguayo, Jl, Millan, M, Alvarez-Gallego, M, Muinelo-Lorenzo, M, Parra, Jm, Muñoz-Muñoz, E, De Chaves-Rodríguez PG, Cánovas-Moreno, G, Rodriguez-Lopez, M, Segura-Sampedro, Jj, García-Granero, A, Redondo-Calvo, Fj, Dyson, S, Thakur, D, Swords, C, Siaw, O, Zelazek, M, Woo, R, Badran, A, Aruparayil, N, Christopoulos, P, Chambers, B, O'Neill, N, Long, Rh, Mccaughey, P, Wong, Ml, Mccain, Rs, Lennox-Warburton, Hc, Moore, C, Manektella, Km, Mcilwaine, S, Rupani, S, Simpson, Dj, Wauchope, J, Ng, M, Christian, L, Crone, A, Sacks, R, Symons, N, Lazzaro, A, Patil, Sd, Roomi, S, Silva, I, Hodgson, Jm, Ly, C, Froud, H, Patel, H, Cay, P, Karwal, Rs, Danquah-Boateng, D, Berry, B, Esmail, Hd, Maripi, H, Bilku, D, Mckelvie, Ma, Miller, K, Maina, A, Velho, R, Hasan, R, Clingan, R, Jah, S, Waite, K, Jones, A, Buckley-Jones, S, Lecky-Thompson, L, Saghir, N, Mansoor, S, Mistry, D, Brown, R, Wong, A, Gurung, S, Wensley, F, Fleming, Ta, Griggs, R, Haines, S, Bedoya, S, Beverstock, A, Johnson, J, Govind, G, Niaz, O, Dyal, A, Tokidis, E, Punj, S, Leusink, A, Rudland, I, Kelly, M, Morgan, R, Al-Musawi, S, Lek, C, Gilbert, A, Gosal, A, Mahoney, R, Parwaiz, I, Mitchard, Mj, Ribeiro, B, Merai, H, Dean, Ea, Khan, S, Baginski, A, Mann, C, Foers, W, Jones, L, Woodward, B, Mcwhirter, Dm, Thomas, At, Gilbert, Tg, Weatherburn, Lw, Pilkington, Jp, Cameron, Fc, Clements, Jd, Mccann, C, Davidson, S, Hackney, L, Clements, Js, Martin, A, Du, Dt, Shakoor, Z, Yen, Sk, Adnan, M, Ranathunga, S, Sana, S, Tay, Yh, Chin, My, Gillespie, M, Brown, Ag, Campbell, U, Chatzikonstantinou, M, Mahendran, B, Flack, T, Chowdhary, M, Lim, Jm, Whiteman, E, Shepherd, Ja, Pedder, A, Siggens, Kl, Lai, Cw, Morrison-Jones, V, Hayat, Z, Nehikhare, I, Macleod, C, Quinn, Hc, Brown, A, Neagle, G, Chok, Sm, Carrano, Fm, Abbassi, Oa, Divekar, Ga, Halmer, S, Adams, Re, Davies, Pl, Wong, Sy, Amarasinghe, R, Tague, Le, Jones, E, Singh, J, Boza, K, Kelly, Sd, Morrison, F, Chan, Wh, Wilson, Ej, Awokoya, Oo, Griffiths, Sn, Kirkham, En, Cotton, Ae, Adimonye, A, Leighton, Pa, Abdelrahman, A, Cartwright, H, Gates, Z, Miguras, M, Khan, K, Louw, C, Grove, T, Badenoch, T, Mckeon, J, Wood, Cs, Leitch, Rp, Sgardelis, P, Perera, Mi, Nagarajan, D, Malam, Y, Theodoropoulou, K, Rajagopal, S, Kaptanis, S, Popova, D, Olagbaiye, O, Tayeh, S, Rigby, S, Harris, Mp, Ren, Kz, Liaw, G, Zhou, S, White, F, Marshall, Cm, Mitchell, Jh, Anderson, Dj, Kanakala, V, Hollingsworth, A, Paramasevon, Kr, Milward, J, Ahmed, S, Fanibi, Bf, Ferguson, N, Dickson, Ea, Shaw, Av, Dixon, F, Morrish, S, Dandy, R, Fooks, P, Sharma, P, Islam, N, Tabain, V, Keegan, R, Ahel, J, Alhammali, T, Graveston, J, Balai, Ej, Rothnie, K, Pankin, Gp, Eiben, Ie, Jackson, Nj, Dhar, M, Nash, D, Dharamavaram, S, Seth, M, Chowdhury, F, Rezacova, M, Seneviratne, N, Turner, Ej, Currow, C, Isherwood, Jd, Hobson, Bm, Lui, Dh, Rodger, V, Ting, N, Photiou, D, Taze, D, Lodhia, S, Earnshaw, L, Kumar, K, Neale, A, Bastianpillai, J, Cipparrone, M, Barrie, A, Nash, Z, Anandan, L, Tailor, K, Vinnicombe, Z, Krivan, S, Kuo, R, Giorga, A, Habib, H, Malik, K, Bogdan, M, Mahon-Daly, Fp, Athersmith, Mj, Strange, Ja, Wheeler, C, Summerfield, L, Khaw, Ra, Ashour, O, Iosif, E, Fadel, M, Gopalakrishnan, K, Orme, N, Williams, S, Rashid, M, Sultana, A, Patel, N, Pearson, R, Yasin, T, Bevan, V, Al-Sarireh, B, Brown, M, Mohd, N, Howie, Ee, Poudevigne, M, Paget, C, Rallage, H, Chui, K, Fawzi, F, Layman, S, Okorocha, E, Jama, Gm, Orawiec, P, Kouli, O, Hassane, A, Kilkenny, J, Devine, Aa, Laurenson, M, Slezak, I, Barker, T, Lau, E, Limbada, M, O'Brien, J, Weaver, J, Hajibandeh, S, Shah, J, Mansour, Mm, Malik, Sn, Davis, S, Trew, F, Bandyopadhyay, Sk, Dart, K, Guru-Naidu, S, Callan, R, Nair, Mk, Alani, M, Sezen, E, Salim, S, Shurlock, J, Siddique, K, Forouzanfar, A, Brews, R, Acharya, A, Jain, A, Tozer, Pj, Warusavitarne, J, Emslie, Km, Collier-Wakefield, O, Sivaloganathan, P, Dobson, C, Elseedawy, M, Mcnally, L, Williams, M, Motiwala, Fh, Choi, S, Asmadi, Aa, Burnside, D, Everden, A, Suriyakumar, S, Sandu, L, Kent, Da, Bowen, J, Long, P, Khair, A, Shah, K, Phelan, L, Pierre, R, Dhari, Aa, Hoff, M, Nickson, S, Setshwaelo, T, Chalk, A, Parkola, Mj, Harlinska, A, Chan, T, Dudek, Jg, Rolph, R, Allen, M, Pollard, H, Gormely, R, Finlayson, H, Ljungqvist, G, Peponis, C, Rahman, M, Dhesi, S, Arshad, F, Faris, Ar, Sooriyamoorthy, T, Springate, El, Barnieh, W, Patel, As, Siddiqui, Za, Chishti, Ia, Ayube-Brown, J, Rabie, Mr, Blake, L, Yardimci, E, Nagendram, S, Neophytou, Gi, Henderson, L, Farhan-Alanie, M, Kong, Cy, Ghazala, R, Evans, J, Hussain, N, Kabir, M, Hraishawi, I, Cox, M, Bailey, Ja, Muhibullah, N, Yanni, F, Stevenson, R, Nair, A, Murphy, C, Mcgucken, O, Pandya, R, Bowerman, H, Lafaurie, G, Van Boxel GI, Shanmugarajah, K, Maragouthakis, D, Hanif, Z, Evans, Jd, Yoganathan, S, Richardson, Td, Cook, V, Clark, Gl, Rigney, B, O'Neill, E, Guliani, J, Chan, D, Harper, F, Sian, T, Boereboom, C, Blackwell, J, Hardy, E, Boyd-Carson, H, Couch, Dg, Barter, Ca, Thoukididou, Sn, Hatt, Jr, Jones, Cs, Dean, S, Rajaretnam, N, Masood, M, Thakral, N, Griffith, D, Doherty, C, Longshaw, A, Peprah, D, Mathew, G, Hook, A, Vance-Daniel, J, Ibrahim, Y, Walters, Kj, Whewell, He, Sherif, Ma, Mckenna, M, O'Sullivan, D, Woodrow, C, Gill, S, Johnstone, A, Gentry, R, Irwin, R, Forgie, A, Welsh, S, Ivey, P, Bullivant, Jk, English, Wj, Osterberg, A, Morowala, A, Al-Faham, Z, Islam, S, Tan, E, Sadek, S, Sihra, N, Shrestha, D, Chong, B, Nadeem, A, Fasuyi, Ja, Patel, Mm, Daureeawoo, R, Okekunle, B, Cheruvu, M, Mazumdar, E, Hussain, A, Patel, C, Mcquaid, M, Banks, A, Robinson, A, Khan, Ms, Riaz, W, Verroiotou, M, Cohen, Ja, Kouroumpas, E, Ghaffari, I, Moradzadeh, J, Kamal, M, Gulamhussein, M, Gaines, E, Ghatorae, S, Clark, S, Savill, A, Hutchinson, B, Chapman, J, Wu, F, Creasy, W, Raymond, M, Grosvenor, S, Odeh, A, Malik, Y, Bansal, H, Grant, C, Raofi, A, Ahmed, B, Mai, D, Souter, J, Hamelmann, Rn, Ikram, S, Durbacz, M, Gilliland, N, Salem, A, Chudek, D, Ladwa, N, Storey, R, Fontaine, C, Toomey, D, Miller, B, Oakey, M, Smoker, H, Chapman, Sj, O'Hagan, Sc, Tahir, W, Wilcox, G, Ahmad, A, Akram, F, Baddams, Ts, Boshier, Pr, Fehervari, M, Easdon, S, Ilozue, T, Adam, Me, Jokhan, S, Foster, A, Nambiar, K, Bohra, P, Janardanan, S, Shanmuganathan, V, Maqboul, F, Ettles, C, Wardle, Sd, Martinou, E, Khasria, A, Bagga, R, Motter, D, Mundkur, N, Pan, Y, Akbari, K, Farrell, Sm, Rahim, A, Gummaraju, A, Mahmoud, A, Akinsola, O, Smallcombe, N, Tarazi, M, Hanley, C, Campbell, Um, Franklin, D, Davidson, Jr, Raza, Ss, Krishnamoorthy, A, Rajjoub, Y, Ali, M, Seddon, Tc, Payne, Re, Das, A, Martin, Lm, Naismith, Kn, Venkata, Up, Manda, Vm, Burns, Km, Huang, J, Samuel, M, Docherty, Ja, Cheah, Wl, Ooi, R, Nyeko-Lacek, M, Marsh, L, Prideaux, A, Li, Ch, Poacher, A, Lee, M, Muzaffar, M, Kara, A, Walsh, E, Sunter, H, Roth, N, Roy, C, Mcmorran, D, Turnbull, A, Layton, Gr, Archer, Je, Yang, P, Douka, E, Amin, V, Borghol, K, Blackford, Od, Bond, S, Baker, B, Mohamed, Wo, Williams, R, Garnham, J, Robb, Hd, Allington, J, Cloney, L, Tamborska, A, Kalia, K, Fung, E, Johnston, Z, Lynch, L, Christides, A, Tan, Hl, Cynthia, G, Tsang, B, Rossi, C, Kaubrys, M, Al-Khafaji, N, Jenkins, M, Peiris, Gb, Gunning, S, Nimako, E, Pandya, D, Hever, P, Amayo, A, Bull, C, Clements, C, Al-Sheikh, M, Savioli, F, Long, M, Horsfield, E, Robertson, C, Ogboru, S, Mcilwrath, Ac, Bell, J, Limb, C, Obeid, N, Rich, Je, Balasubramaniam, A, Mashar, R, Taylor, M, Bruce, Js, Dennison, G, Curtis, Nj, Ezerska, E, Ellis, B, Wiggill, S, Tee, A, Ng, S, Carder, C, Abdelwahed, A, Chandler, Sb, Tinsley, Bj, Finotti, E, Occhioni, G, Cossu, F, Vulcano, I, Viscosi, F, Michelini, M, Compagnoni, B, Sepe, C, Isolani, Sm, Regina, G, Alagna, V, Martorelli, G, Gabbianelli, C, Moroni, P, Zuin, M, Conci, S, Lazzari, G, Costamagna, D, Zurleni, Tz, Altomare, Ma, Desiderio, J, Di Cintio, A, Gemini, A, Trastulli, S, Viviani, E, Tomasoni, M, Montori, G, Harder, G, Argenti, F, Malabarba, S, Checcacci, P, Montanelli, P, Guerra, F, Skalamera, I, Staderini, F, Grandi, S, Nelli, T, Coratti, F, Sorrentino, L, Maffioli, A, Cavallo, D, Bondurri, A, Groppo, G, Curti, R, Solaini, L, Xidas, A, Manias, T, Delogu, D, Vacca, A, Solinas, L, Corbellini, C, Fiore, L, Nigro, A, Santurro, L, Angrisani, M, Sparta, C, Lorettu, A, Mura, Fa, Ruggiu, Gv, Pirari, Pf, Pau, R, Melis, M, Piu, F, Patti, S, Deserra, A, Angelieri, D, Del Basso, C, Rossi, D, Iannone, I, De Padua, C, Giubilo, C, Falaschi, F, Cirillo, B, Gordini, L, Podda, F, Sanna, S, Saba, A, Poillucci, G, Pinna, E, Messina, A, Sena, G, Cardona, R, De Luca, E, Sacco, R, Vescio, G, Ammendola, M, Romano, R, Bianco, A, Bonfante, P, D'Ambra, L, Feleppa, C, Gennai, A, Lizzi, V, Moggia, E, Imperatore, M, Bolzon, S, Belvedere, A, Amaducci, E, Ripoli, Mc, Segalini, E, Cervellera, M, Vaccari, S, Eretta, Co, O'Neill, R, Llewelyn, O, Jones, N, Clerici, F, Ballabio, M, Andolfi, E, Angelini, M, Fontani, A, Miranda, E, Scricciolo, M, Provenza, G, Pellicanò, Ga, Pulighe, F, Argenio, G, Melis, A, Balestra, F, Anania, M, Cruccu, A, Massaiu, C, Murru, Ml, Martino, A, Luzzi, Ap, La Valle, G, Chillitupa, Cz, Bartoli, A, Conti, D, Spaziani, A, Bellochi, R, Listorti, C, 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Samuel M., Docherty J.A., Cheah W.L., Ooi R., Nyeko-Lacek M., Marsh L., Prideaux A., Li C.H., Poacher A., Lee M., Muzaffar M., Kara A., Walsh E., Sunter H., Roth N., Roy C., Mcmorran D., Turnbull A., Layton G.R., Archer J.E., Yang P., Douka E., Amin V., Borghol K., Blackford O.D., Bond S., Baker B., Mohamed W.O., Williams R., Garnham J., Robb H.D., Allington J., Cloney L., Tamborska A., Kalia K., Fung E., Johnston Z., Lynch L., Christides A., Tan H.L., Cynthia G., Tsang B., Rossi C., Kaubrys M., Al-Khafaji N., Jenkins M., Peiris G.B., Gunning S., Nimako E., Pandya D., Hever P., Amayo A., Bull C., Clements C., Al-Sheikh M., Savioli F., Long M., Horsfield E., Robertson C., Ogboru S., Mcilwrath A.C., Bell J., Limb C., Obeid N., Rich J.E., Balasubramaniam A., Mashar R., Taylor M., Bruce J.S., Dennison G., Curtis N.J., Ezerska E., Ellis B., Wiggill S., Tee A., Ng S., Carder C., Abdelwahed A., Chandler S.B., Tinsley B.J., Finotti E., Occhioni G., Cossu F., Vulcano I., Viscosi F., Michelini 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D'Ambra L., Feleppa C., Gennai A., Lizzi V., Moggia E., Imperatore M., Bolzon S., Belvedere A., Amaducci E., Ripoli M.C., Segalini E., Cervellera M., Vaccari S., Eretta C.O., O'Neill R., Llewelyn O., Jones N., Clerici F., Ballabio M., Andolfi E., Angelini M., Fontani A., Miranda E., Scricciolo M., Provenza G., Pellicano G.A., Pulighe F., Argenio G., Melis A., Balestra F., Anania M., Cruccu A., Massaiu C., Murru M.L., Martino A., Luzzi A.P., La Valle G., Chillitupa C.Z., Bartoli A., Conti D., Spaziani A., Bellochi R., Listorti C., Salandini M.C., Carlucci M., Tenconi S.M., Cannavo M., Marano A., Giuffrida M.C., Cannata G., Pellegrino L., Giraudo G., Baraghini M., Garzi A., Giudicissi R., Zalla T., Romoli L., Vannucchi A., Giani I., Feroci F., Calussi M., Ribaudo M., Fiorot A., Stecca T., Nistri C., Fornasier C., Valiani S.V., Brunelli D.B., Evoli L.E., Giuliani N.G., Contine A.C., Renzi C.R., Feo C.V., Anania G., Carcoforo P., Aisoni F., Licari L., Tutino R., Cocorullo G., Silvestri V., 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J., Abellan M., Padilla E., Mambrilla-Herrero S., Plua-Muniz K.T., Bailon-Cuadrado M., Tejero-Pintor F.J., Choolani-Bhojwani E., Vila-Zarate C., Delgado-Plasencia L.J., Ponchietti L., Cousins L., Busuttil A., Baird C., Drye N., Brown O.D., Mansour S., Anderson O., Mahapatra R., Clements J.A., D'Souza N., Littlehales D.J., Tang A.M., Byrne B.E., Cunha P., Ogbuokiri C., Eiben P., Gravante G., Kho H., Dobbs S., Doulias T., Ng J., Wilson M., Venugopal R., Wolff J., Akhtar K., Walji H.D., Tognarelli J.M., Knight K.A., Ansari A., Hussaini S.A., Wright E., Brewer H., Rinkoff S., Harries R.L., Fairfield C.J., Abbott T., Jackson A., Wright H.L., Walters U., Carney K., Logan P.C., Mughal Z., Strachan E., Chasty B., Ma J., Mazzeo C., Badii B., Armellini A., Grassia M., Perin A., Ruzzenente A., Magnoli M., Depalma N., Longheu A., Papandrea M., Dova L., De Prizio M., Gusai G.P., Di Zitti L., Geretto P., Azabdaftari A., Chianese G., Elbetti C., Ruffolo C., Giaccari S., Devezas V., Ferreira J.S., Peixoto R., Alshafei A., Simo V., Jose H.S., Ugarte-Sierra B., Salva A.B., Gomez N., Marinello F., Medina-Arana V., Vega L., Ballester M.M., Espina B., Prieto-Nieto M.I., Rodriguez E.C., Padilla-Valverde D., and Duran-Munoz-Cruzado V.M.
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Adult ,humanos ,Decision Making ,Risk Assessment ,NO ,apendicectomía ,apendicitis ,evaluación de riesgos ,Appendectomy ,Humans ,hospital ,General ,collaborative ,LS7_4 ,right iliac fossa ,appendicitis ,emergency service ,Original Articles ,adulto ,Appendicitis ,adult ,appendectomy ,humans ,risk assessment ,decision making ,Lower GI ,Original Article ,appendicitis, prediction models, right iliac fossa pain ,Emergency Service, Hospital ,toma de decisión - Abstract
Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P, Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making were identified by identifying UK adults at low risk of appendicitis. An online calculator is available (http://appy-risk.org). WCC, white cell count; CRP, C‐reactive protein; AIRS, Appendicitis Inflammatory Response Score; AAS, Adult Appendicitis Score. Important differences between men and women
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- 2019
14. Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder
- Author
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Robert Maier, Gerhard Moser, Guo-Bo Chen, Stephan Ripke, William Coryell, James B. Potash, William A. Scheftner, Jianxin Shi, Myrna M. Weissman, Christina M. Hultman, Mikael Landén, Douglas F. Levinson, Kenneth S. Kendler, Jordan W. Smoller, Naomi R. Wray, S. Hong Lee, Devin Absher, Ingrid Agartz, Huda Akil, Farooq Amin, Ole A. Andreassen, Adebayo Anjorin, Richard Anney, Dan E. Arking, Philip Asherson, Maria H. Azevedo, Lena Backlund, Judith A. Badner, Anthony J. Bailey, Tobias Banaschewski, Jack D. Barchas, Michael R. Barnes, Thomas B. Barrett, Nicholas Bass, Agatino Battaglia, Michael Bauer, Mònica Bayés, Frank Bellivier, Sarah E. Bergen, Wade Berrettini, Catalina Betancur, Thomas Bettecken, Joseph Biederman, Elisabeth B. Binder, Donald W. Black, Douglas H.R. Blackwood, Cinnamon S. Bloss, Michael Boehnke, Dorret I. Boomsma, Gerome Breen, René Breuer, Richard Bruggeman, Nancy G. Buccola, Jan K. Buitelaar, William E. Bunney, Joseph D. Buxbaum, William F. Byerley, Sian Caesar, Wiepke Cahn, Rita M. Cantor, Miguel Casas, Aravinda Chakravarti, Kimberly Chambert, Khalid Choudhury, Sven Cichon, C. Robert Cloninger, David A. Collier, Edwin H. Cook, Hilary Coon, Bru Cormand, Paul Cormican, Aiden Corvin, William H. Coryell, Nicholas Craddock, David W. Craig, Ian W. Craig, Jennifer Crosbie, Michael L. Cuccaro, David Curtis, Darina Czamara, Mark J. Daly, Susmita Datta, Geraldine Dawson, Richard Day, Eco J. De Geus, Franziska Degenhardt, Bernie Devlin, Srdjan Djurovic, Gary J. Donohoe, Alysa E. Doyle, Jubao Duan, Frank Dudbridge, Eftichia Duketis, Richard P. Ebstein, Howard J. Edenberg, Josephine Elia, Sean Ennis, Bruno Etain, Ayman Fanous, Stephen V. Faraone, Anne E. Farmer, I. Nicol Ferrier, Matthew Flickinger, Eric Fombonne, Tatiana Foroud, Josef Frank, Barbara Franke, Christine Fraser, Robert Freedman, Nelson B. Freimer, Christine M. Freitag, Marion Friedl, Louise Frisén, Louise Gallagher, Pablo V. Gejman, Lyudmila Georgieva, Elliot S. Gershon, Daniel H. Geschwind, Ina Giegling, Michael Gill, Scott D. Gordon, Katherine Gordon-Smith, Elaine K. Green, Tiffany A. Greenwood, Dorothy E. Grice, Magdalena Gross, Detelina Grozeva, Weihua Guan, Hugh Gurling, Lieuwe De Haan, Jonathan L. Haines, Hakon Hakonarson, Joachim Hallmayer, Steven P. Hamilton, Marian L. Hamshere, Thomas F. Hansen, Annette M. Hartmann, Martin Hautzinger, Andrew C. Heath, Anjali K. Henders, Stefan Herms, Ian B. Hickie, Maria Hipolito, Susanne Hoefels, Peter A. Holmans, Florian Holsboer, Witte J. Hoogendijk, Jouke-Jan Hottenga, Vanessa Hus, Andrés Ingason, Marcus Ising, Stéphane Jamain, Ian Jones, Lisa Jones, Anna K. Kähler, René S. Kahn, Radhika Kandaswamy, Matthew C. Keller, John R. Kelsoe, James L. Kennedy, Elaine Kenny, Lindsey Kent, Yunjung Kim, George K. Kirov, Sabine M. Klauck, Lambertus Klei, James A. Knowles, Martin A. Kohli, Daniel L. Koller, Bettina Konte, Ania Korszun, Lydia Krabbendam, Robert Krasucki, Jonna Kuntsi, Phoenix Kwan, Niklas Långström, Mark Lathrop, Jacob Lawrence, William B. Lawson, Marion Leboyer, David H. Ledbetter, Phil H. Lee, Todd Lencz, Klaus-Peter Lesch, Cathryn M. Lewis, Jun Li, Paul Lichtenstein, Jeffrey A. Lieberman, Dan-Yu Lin, Don H. Linszen, Chunyu Liu, Falk W. Lohoff, Sandra K. Loo, Catherine Lord, Jennifer K. Lowe, Susanne Lucae, Donald J. MacIntyre, Pamela A.F. Madden, Elena Maestrini, Patrik K.E. Magnusson, Pamela B. Mahon, Wolfgang Maier, Anil K. Malhotra, Shrikant M. Mane, Christa L. Martin, Nicholas G. Martin, Manuel Mattheisen, Keith Matthews, Morten Mattingsdal, Steven A. McCarroll, Kevin A. McGhee, James J. McGough, Patrick J. McGrath, Peter McGuffin, Melvin G. McInnis, Andrew McIntosh, Rebecca McKinney, Alan W. McLean, Francis J. McMahon, William M. McMahon, Andrew McQuillin, Helena Medeiros, Sarah E. Medland, Sandra Meier, Ingrid Melle, Fan Meng, Jobst Meyer, Christel M. Middeldorp, Lefkos Middleton, Vihra Milanova, Ana Miranda, Anthony P. Monaco, Grant W. Montgomery, Jennifer L. Moran, Daniel Moreno-De-Luca, Gunnar Morken, Derek W. Morris, Eric M. Morrow, Valentina Moskvina, Bryan J. Mowry, Pierandrea Muglia, Thomas W. Mühleisen, Bertram Müller-Myhsok, Michael Murtha, Richard M. Myers, Inez Myin-Germeys, Benjamin M. Neale, Stan F. Nelson, Caroline M. Nievergelt, Ivan Nikolov, Vishwajit Nimgaonkar, Willem A. Nolen, Markus M. Nöthen, John I. Nurnberger, Evaristus A. Nwulia, Dale R. Nyholt, Michael C. O’Donovan, Colm O’Dushlaine, Robert D. Oades, Ann Olincy, Guiomar Oliveira, Line Olsen, Roel A. Ophoff, Urban Osby, Michael J. Owen, Aarno Palotie, Jeremy R. Parr, Andrew D. Paterson, Carlos N. Pato, Michele T. Pato, Brenda W. Penninx, Michele L. Pergadia, Margaret A. Pericak-Vance, Roy H. Perlis, Benjamin S. Pickard, Jonathan Pimm, Joseph Piven, Danielle Posthuma, Fritz Poustka, Peter Propping, Shaun M. Purcell, Vinay Puri, Digby J. Quested, Emma M. Quinn, Josep Antoni Ramos-Quiroga, Henrik B. Rasmussen, Soumya Raychaudhuri, Karola Rehnström, Andreas Reif, Marta Ribasés, John P. Rice, Marcella Rietschel, Kathryn Roeder, Herbert Roeyers, Lizzy Rossin, Aribert Rothenberger, Guy Rouleau, Douglas Ruderfer, Dan Rujescu, Alan R. Sanders, Stephan J. Sanders, Susan L. Santangelo, Russell Schachar, Martin Schalling, Alan F. Schatzberg, Gerard D. Schellenberg, Stephen W. Scherer, Nicholas J. Schork, Thomas G. Schulze, Johannes Schumacher, Markus Schwarz, Edward Scolnick, Laura J. Scott, Joseph A. Sergeant, Paul D. Shilling, Stanley I. Shyn, Jeremy M. Silverman, Pamela Sklar, Susan L. Slager, Susan L. Smalley, Johannes H. Smit, Erin N. Smith, Edmund J.S. Sonuga-Barke, David St Clair, Matthew State, Michael Steffens, Hans-Christoph Steinhausen, John S. Strauss, Jana Strohmaier, T. Scott Stroup, Patrick F. Sullivan, James Sutcliffe, Peter Szatmari, Szabocls Szelinger, Anita Thapar, Srinivasa Thirumalai, Robert C. Thompson, Alexandre A. Todorov, Federica Tozzi, Jens Treutlein, Jung-Ying Tzeng, Manfred Uhr, Edwin J.C.G. van den Oord, Gerard Van Grootheest, Jim Van Os, Astrid M. Vicente, Veronica J. Vieland, John B. Vincent, Peter M. Visscher, Christopher A. Walsh, Thomas H. Wassink, Stanley J. Watson, Lauren A. Weiss, Thomas Werge, Thomas F. Wienker, Durk Wiersma, Ellen M. Wijsman, Gonneke Willemsen, Nigel Williams, A. Jeremy Willsey, Stephanie H. Witt, Wei Xu, Allan H. Young, Timothy W. Yu, Stanley Zammit, Peter P. Zandi, Peng Zhang, Frans G. Zitman, Sebastian Zöllner, University of Zurich, Lee, S Hong, Epidemiology and Data Science, Psychiatry, EMGO - Mental health, NCA - Neurobiology of mental health, Human genetics, NCA - Brain mechanisms in health and disease, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Biological Psychology, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, Maier, Robert, Moser, Gerhard, Chen, Guo-Bo, Ripke, Stephan, Coryell, William, Potash, James B, Scheftner, William A, Shi, Jianxin, Weissman, Myrna M, Hultman, Christina M, Landen, Mikael, Levinson, Douglas F, Kendler, Kenneth S, Smoller, Jordan, Wray, Naomi R, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Oades, Robert D. (Beitragende*r), Génétique de l'autisme = Genetics of Autism (NPS-01), Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of St Andrews. School of Medicine, University of St Andrews. Institute of Behavioural and Neural Sciences, Neurosciences Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANS - Amsterdam Neuroscience, Adult Psychiatry, Child Psychiatry, Maier R., Moser G., Chen G.-B., Ripke S., Coryell W., Potash J.B., Scheftner W.A., Shi J., Weissman M.M., Hultman C.M., Landen M., Levinson D.F., Kendler K.S., Smoller J.W., Wray N.R., Lee S.H., Absher D., Agartz I., Akil H., Amin F., Andreassen O.A., Anjorin A., Anney R., Arking D.E., Asherson P., Azevedo M.H., Backlund L., Badner J.A., Bailey A.J., Banaschewski T., Barchas J.D., Barnes M.R., Barrett T.B., Bass N., Battaglia A., Bauer M., Bayes M., Bellivier F., Bergen S.E., Berrettini W., Betancur C., Bettecken T., Biederman J., Binder E.B., Black D.W., Blackwood D.H.R., Bloss C.S., Boehnke M., Boomsma D.I., Breen G., Breuer R., Bruggeman R., Buccola N.G., Buitelaar J.K., Bunney W.E., Buxbaum J.D., Byerley W.F., Caesar S., Cahn W., Cantor R.M., Casas M., Chakravarti A., Chambert K., Choudhury K., Cichon S., Robert Cloninger C., Collier D.A., Cook E.H., Coon H., Cormand B., Cormican P., Corvin A., Coryell W.H., Craddock N., Craig D.W., Craig I.W., Crosbie J., Cuccaro M.L., Curtis D., Czamara D., Daly M.J., Datta S., Dawson G., Day R., De Geus E.J., Degenhardt F., Devlin B., Djurovic S., Donohoe G.J., Doyle A.E., Duan J., Dudbridge F., Duketis E., Ebstein R.P., Edenberg H.J., Elia J., Ennis S., Etain B., Fanous A., Faraone S.V., Farmer A.E., Nicol Ferrier I., Flickinger M., Fombonne E., Foroud T., Frank J., Franke B., Fraser C., Freedman R., Freimer N.B., Freitag C.M., Friedl M., Frisen L., Gallagher L., Gejman P.V., Georgieva L., Gershon E.S., Geschwind D.H., Giegling I., Gill M., Gordon S.D., Gordon-Smith K., Green E.K., Greenwood T.A., Grice D.E., Gross M., Grozeva D., Guan W., Gurling H., De Haan L., Haines J.L., Hakonarson H., Hallmayer J., Hamilton S.P., Hamshere M.L., Hansen T.F., Hartmann A.M., Hautzinger M., Heath A.C., Henders A.K., Herms S., Hickie I.B., Hipolito M., Hoefels S., Holmans P.A., Holsboer F., Hoogendijk W.J., Hottenga J.-J., Hus V., Ingason A., Ising M., Jamain S., Jones I., Jones L., Kahler A.K., Kahn R.S., Kandaswamy R., Keller M.C., Kelsoe J.R., Kennedy J.L., Kenny E., Kent L., Kim Y., Kirov G.K., Klauck S.M., Klei L., Knowles J.A., Kohli M.A., Koller D.L., Konte B., Korszun A., Krabbendam L., Krasucki R., Kuntsi J., Kwan P., Langstrom N., Lathrop M., Lawrence J., Lawson W.B., Leboyer M., Ledbetter D.H., Lee P.H., Lencz T., Lesch K.-P., Lewis C.M., Li J., Lichtenstein P., Lieberman J.A., Lin D.-Y., Linszen D.H., Liu C., Lohoff F.W., Loo S.K., Lord C., Lowe J.K., Lucae S., MacIntyre D.J., Madden P.A.F., Maestrini E., Magnusson P.K.E., Mahon P.B., Maier W., Malhotra A.K., Mane S.M., Martin C.L., Martin N.G., Mattheisen M., Matthews K., Mattingsdal M., McCarroll S.A., McGhee K.A., McGough J.J., McGrath P.J., McGuffin P., McInnis M.G., McIntosh A., McKinney R., McLean A.W., McMahon F.J., McMahon W.M., McQuillin A., Medeiros H., Medland S.E., Meier S., Melle I., Meng F., Meyer J., Middeldorp C.M., Middleton L., Milanova V., Miranda A., Monaco A.P., Montgomery G.W., Moran J.L., Moreno-De-Luca D., Morken G., Morris D.W., Morrow E.M., Moskvina V., Mowry B.J., Muglia P., Muhleisen T.W., Muller-Myhsok B., Murtha M., Myers R.M., Myin-Germeys I., Neale B.M., Nelson S.F., Nievergelt C.M., Nikolov I., Nimgaonkar V., Nolen W.A., Nothen M.M., Nurnberger J.I., Nwulia E.A., Nyholt D.R., O'Donovan M.C., O'Dushlaine C., Oades R.D., Olincy A., Oliveira G., Olsen L., Ophoff R.A., Osby U., Owen M.J., Palotie A., Parr J.R., Paterson A.D., Pato C.N., Pato M.T., Penninx B.W., Pergadia M.L., Pericak-Vance M.A., Perlis R.H., Pickard B.S., Pimm J., Piven J., Posthuma D., Poustka F., Propping P., Purcell S.M., Puri V., Quested D.J., Quinn E.M., Ramos-Quiroga J.A., Rasmussen H.B., Raychaudhuri S., Rehnstrom K., Reif A., Ribases M., Rice J.P., Rietschel M., Roeder K., Roeyers H., Rossin L., Rothenberger A., Rouleau G., Ruderfer D., Rujescu D., Sanders A.R., Sanders S.J., Santangelo S.L., Schachar R., Schalling M., Schatzberg A.F., Schellenberg G.D., Scherer S.W., Schork N.J., Schulze T.G., Schumacher J., Schwarz M., Scolnick E., Scott L.J., Sergeant J.A., Shilling P.D., Shyn S.I., Silverman J.M., Sklar P., Slager S.L., Smalley S.L., Smit J.H., Smith E.N., Sonuga-Barke E.J.S., St Clair D., State M., Steffens M., Steinhausen H.-C., Strauss J.S., Strohmaier J., Scott Stroup T., Sullivan P.F., Sutcliffe J., Szatmari P., Szelinger S., Thapar A., Thirumalai S., Thompson R.C., Todorov A.A., Tozzi F., Treutlein J., Tzeng J.-Y., Uhr M., van den Oord E.J.C.G., Van Grootheest G., Van Os J., Vicente A.M., Vieland V.J., Vincent J.B., Visscher P.M., Walsh C.A., Wassink T.H., Watson S.J., Weiss L.A., Werge T., Wienker T.F., Wiersma D., Wijsman E.M., Willemsen G., Williams N., Jeremy Willsey A., Witt S.H., Xu W., Young A.H., Yu T.W., Zammit S., Zandi P.P., Zhang P., Zitman F.G., and Zollner S.
- Subjects
Netherlands Twin Register (NTR) ,Multifactorial Inheritance ,Multivariate analysis ,Bipolar Disorder ,genome annotation ,Medizin ,R Medicine (General) ,Medical and Health Sciences ,Genome-wide association studies ,0302 clinical medicine ,2.5 Research design and methodologies (aetiology) ,GWAS ,Genetics(clinical) ,Aetiology ,Multivariate Analysi ,Genetics (clinical) ,Genetics & Heredity ,bipolar disorder ,0303 health sciences ,education.field_of_study ,Depression ,Mental Disorders ,Single Nucleotide ,3rd-DAS ,Biological Sciences ,10058 Department of Child and Adolescent Psychiatry ,Serious Mental Illness ,Psychiatric Disorders ,3. Good health ,Mental Health ,Schizophrenia ,Mental Disorder ,Linear Model ,Major depressive disorder ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Risk assessment ,Human ,medicine.medical_specialty ,2716 Genetics (clinical) ,Genetics, Medical ,Population ,SNP ,610 Medicine & health ,QH426 Genetics ,Best linear unbiased prediction ,Polymorphism, Single Nucleotide ,Risk Assessment ,03 medical and health sciences ,1311 Genetics ,Medical ,Report ,medicine ,Genetics ,Humans ,Bipolar disorder ,Genetic Testing ,Polymorphism ,education ,Psychiatry ,QH426 ,030304 developmental biology ,Depressive Disorder ,Depressive Disorder, Major ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,business.industry ,Cross-Disorder Working Group of the Psychiatric Genomics Consortium ,Prevention ,Human Genome ,Major ,medicine.disease ,genetic risk prediction ,R1 ,Brain Disorders ,schizophrenia ,Sample size determination ,Perturbações do Desenvolvimento Infantil e Saúde Mental ,Multivariate Analysis ,Linear Models ,business ,depressive disorders ,030217 neurology & neurosurgery - Abstract
Cross-Disorder Working Group of the Psychiatric Genomics Consortium - Vicente A.M. Acessível em: http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25640677/ Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a heterogeneous population of patients by their predicted genetic risk. However, for polygenic traits, such as psychiatric disorders, the accuracy of risk prediction is low. Here we use a multivariate linear mixed model and apply multi-trait genomic best linear unbiased prediction for genetic risk prediction. This method exploits correlations between disorders and simultaneously evaluates individual risk for each disorder. We show that the multivariate approach significantly increases the prediction accuracy for schizophrenia, bipolar disorder, and major depressive disorder in the discovery as well as in independent validation datasets. By grouping SNPs based on genome annotation and fitting multiple random effects, we show that the prediction accuracy could be further improved. The gain in prediction accuracy of the multivariate approach is equivalent to an increase in sample size of 34% for schizophrenia, 68% for bipolar disorder, and 76% for major depressive disorders using single trait models. Because our approach can be readily applied to any number of GWAS datasets of correlated traits, it is a flexible and powerful tool to maximize prediction accuracy. With current sample size, risk predictors are not useful in a clinical setting but already are a valuable research tool, for example in experimental designs comparing cases with high and low polygenic risk
- Published
- 2015
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