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1. Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis

Author

Abdi, Zeinab, Agosta, Federica, Ahmed, Samrah, Alcolea, Daniel, Allen, Isabel Elaine, Allinson, Kieren S.J., Apostolova, Liana G., Arighi, Andrea, Balasa, Mircea, Barkhof, Frederik, Best, John, Boon, Baayla D., Brandt, Katherine D., Brosch, Jared, Burrell, James, Butler, Christopher R., Calandri, Ismael, Caminiti, Silvia Paola, Canu, Elisa, Carrillo, Maria C., Caso, Francesca, Chapleau, Marianne, Chrem Mendez, Patricio, Chu, Min, Crutch, Sebastian, Cordato, Nicholas, Costa, Ana Sofia, Cui, Yue, Dickerson, Bradford, Dickson, Dennis W., Duara, Ranjan, Dubois, Bruno, Eldaief, Mark, Farlow, Martin, Fenoglio, Chiara, Filippi, Massimo, Fliessbach, Klaus, Formaglio, Maïté, Fortea, Juan, Fox, Nick, Foxe, David, Tilikete, Caroline Froment, Frosch, Matthew P., Fumagalli, Giorgio Giulio, Galasko, Douglas, Galimberti, Daniela, Garat, Oscar, Giardinieri, Giulia, Graff-Radford, Jonathan, Graff-Radford, Neill R., Grinberg, Lea, Groot, Colin, Hake, Ann Marie, Hansson, Oskar, Headley, Alison, Hernandez, Micaela, Hochberg, Daisy, Hodges, John R., Hof, Patrick R., Holton, Janice, Hromas, Gabrielle, Gala, Ignacio Illán, Irwin, David J., Jaunmuktane, Zane, Jing, Donglai, Josephs, Keith, Kagerer, Sonja M., Kasuga, Kensaku, Kong, Yu, Kövari, Enikö, Lacombe-Thibault, Mégane, Lleó, Alberto, Laforce, Robert, La Joie, Renaud, Lashley, Tammaryn, Leger, Gabriel, Levin, Netta, Levy, Richard, Liu, Yang, Liu, Li, Lladó Plarrumaní, Albert, Lucente, Diane E., Machulda, Mary M., Magnani, Giuseppe, Magnin, Eloi, Malpetti, Maura, Matthews, Brandy, McGinnis, Scott, Mendez, Mario F., Mesulam, Marsel, Migliaccio, Raffaella, Miklitz, Carolin, Miller, Zachary A., Montembeault, Maxime, Murray, Melissa E., Mundada, Nidhi, Nemes, Sara, Nestor, Peter J., Ocal, Dilek, Ossenkoppele, Rik, Paterson, Ross, Pelak, Victoria, Perani, Daniela, Phillips, Jeffrey, Piguet, Olivier, Pijnenburg, Yolande, Putcha, Deepti, Quimby, Megan, Rabinovici, Gil D., Reetz, Kathrin, Rein, Netaniel, Revesz, Tamas, Rezaii, Neguine, Rodriguez-Porcel, Federico, Rogalski, Emily, Rowe, James B., Ryan, Natalie, Sanchez-Valle, Raquel, Sacchi, Luca, Santos-Santos, Miguel Ángel, Schott, Jonathan M., Seeley, William, Sherman, Janet, Spina, Salvatore, Stomrud, Erik, Sullivan, A. Campbell, Tanner, Jeremy, Tideman, Pontus, Tokutake, Takayoshi, Tondo, Giacomo, Touroutoglou, Alexandra, Tousi, Babak, Vandenberghe, Rik, van der Flier, Wiesje, Walker, Jamie M., Weintraub, Sandra, Whitwell, Jennifer L., Wolk, David A., Wong, Bonnie, Wu, Liyong, Xie, Kexin, Yong, Keir, Apostolova, Liana, Boon, Baayla D C, Grinberg, Lea T, Irwin, David J, Josephs, Keith A, Mendez, Mario F, Mendez, Patricio Chrem, Miller, Zachary A, Murray, Melissa E, Nemes, Sára, Schott, Jonathan M, Sullivan, A Campbell, Walker, Jamie, Whitwell, Jennifer L, Wolk, David A, and Rabinovici, Gil D

Published
2024
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2. Artificial intelligence classifies primary progressive aphasia from connected speech.

Author

Rezaii, Neguine, Hochberg, Daisy, Quimby, Megan, Wong, Bonnie, Brickhouse, Michael, Touroutoglou, Alexandra, Dickerson, Bradford C, and Wolff, Phillip

Subjects
GENERATIVE artificial intelligence, LANGUAGE models, NATURAL language processing, ARTIFICIAL intelligence, CEREBRAL atrophy
Abstract

Neurodegenerative dementia syndromes, such as primary progressive aphasias (PPA), have traditionally been diagnosed based, in part, on verbal and non-verbal cognitive profiles. Debate continues about whether PPA is best divided into three variants and regarding the most distinctive linguistic features for classifying PPA variants. In this cross-sectional study, we initially harnessed the capabilities of artificial intelligence and natural language processing to perform unsupervised classification of short, connected speech samples from 78 pateints with PPA. We then used natural language processing to identify linguistic features that best dissociate the three PPA variants. Large language models discerned three distinct PPA clusters, with 88.5% agreement with independent clinical diagnoses. Patterns of cortical atrophy of three data-driven clusters corresponded to the localization in the clinical diagnostic criteria. In the subsequent supervised classification, 17 distinctive features emerged, including the observation that separating verbs into high- and low-frequency types significantly improved classification accuracy. Using these linguistic features derived from the analysis of short, connected speech samples, we developed a classifier that achieved 97.9% accuracy in classifying the four groups (three PPA variants and healthy controls). The data-driven section of this study showcases the ability of large language models to find natural partitioning in the speech of patients with PPA consistent with conventional variants. In addition, the work identifies a robust set of language features indicative of each PPA variant, emphasizing the significance of dividing verbs into high- and low-frequency categories. Beyond improving diagnostic accuracy, these findings enhance our understanding of the neurobiology of language processing. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis

Author

Chapleau, Marianne, primary, La Joie, Renaud, additional, Yong, Keir, additional, Agosta, Federica, additional, Allen, Isabel Elaine, additional, Apostolova, Liana, additional, Best, John, additional, Boon, Baayla D C, additional, Crutch, Sebastian, additional, Filippi, Massimo, additional, Fumagalli, Giorgio Giulio, additional, Galimberti, Daniela, additional, Graff-Radford, Jonathan, additional, Grinberg, Lea T, additional, Irwin, David J, additional, Josephs, Keith A, additional, Mendez, Mario F, additional, Mendez, Patricio Chrem, additional, Migliaccio, Raffaella, additional, Miller, Zachary A, additional, Montembeault, Maxime, additional, Murray, Melissa E, additional, Nemes, Sára, additional, Pelak, Victoria, additional, Perani, Daniela, additional, Phillips, Jeffrey, additional, Pijnenburg, Yolande, additional, Rogalski, Emily, additional, Schott, Jonathan M, additional, Seeley, William, additional, Sullivan, A Campbell, additional, Spina, Salvatore, additional, Tanner, Jeremy, additional, Walker, Jamie, additional, Whitwell, Jennifer L, additional, Wolk, David A, additional, Ossenkoppele, Rik, additional, Rabinovici, Gil D, additional, Abdi, Zeinab, additional, Ahmed, Samrah, additional, Alcolea, Daniel, additional, Allinson, Kieren S.J., additional, Arighi, Andrea, additional, Balasa, Mircea, additional, Barkhof, Frederik, additional, Brandt, Katherine D., additional, Brosch, Jared, additional, Burrell, James, additional, Butler, Christopher R., additional, Calandri, Ismael, additional, Caminiti, Silvia Paola, additional, Canu, Elisa, additional, Carrillo, Maria C., additional, Caso, Francesca, additional, Chu, Min, additional, Cordato, Nicholas, additional, Costa, Ana Sofia, additional, Cui, Yue, additional, Dickerson, Bradford, additional, Dickson, Dennis W., additional, Duara, Ranjan, additional, Dubois, Bruno, additional, Eldaief, Mark, additional, Farlow, Martin, additional, Feneglio, Chiara, additional, Fliessbach, Klaus, additional, Formaglio, Maïté, additional, Fortea, Juan, additional, Fox, Nick, additional, Foxe, David, additional, Tilikete, Caroline Froment, additional, Frosch, Matthew P., additional, Galasko, Douglas, additional, Garat, Oscar, additional, Giardinieri, Giulia, additional, Graff-Radford, Neill R., additional, Groot, Colin, additional, Hake, Ann Marie, additional, Hansson, Oskar, additional, Headley, Alison, additional, Hernandez, Micaela, additional, Hochberg, Daisy, additional, Hodges, John R., additional, Hof, Patrick R., additional, Holton, Janice, additional, Hromas, Gabrielle, additional, Illán Gala, Ignacio, additional, Jaunmuktane, Zane, additional, Jing, Donglai, additional, Kagerer, Sonja M., additional, Kasuga, Kensaku, additional, Kong, Yu, additional, Kövari, Enikö, additional, Lacombe-Thibault, Mégane, additional, Lleó Plarrumaní, Alberto, additional, Lucente, Diane E., additional, Machulda, Mary M., additional, Magnani, Giuseppe, additional, Magnin, Eloi, additional, Malpetti, Maura, additional, Matthews, Brandy, additional, McGinnis, Scott, additional, Mesulam, Marsel, additional, Miklitz, Carolin, additional, Mundada, Nidhi, additional, Nestor, Peter J., additional, Ocal, Dilek, additional, Paterson, Ross, additional, Piguet, Olivier, additional, Putcha, Deepti, additional, Quimby, Megan, additional, Reetz, Kathrin, additional, Rein, Netaniel, additional, Revesz, Tamas, additional, Rezaii, Neguine, additional, Rodriguez-Porcel, Federico, additional, Rowe, James B., additional, Ryan, Natalie, additional, Sanchez-Valle, Raquel, additional, Sacchi, Luca, additional, Santos-Santos, Miguel Ángel, additional, Sherman, Janet, additional, Stomrud, Erik, additional, Tideman, Pontus, additional, Tokutake, Takayoshi, additional, Tondo, Giacomo, additional, Touroutoglou, Alexandra, additional, Tousi, Babak, additional, Vandenberghe, Rik, additional, van der Flier, Wiesje, additional, Weintraub, Sandra, additional, Wong, Bonnie, additional, Wu, Liyong, additional, and Xie, Kexin, additional

Published
2024
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8. Transcranial Magnetic Stimulation improves language and language network functional connectivity in a patient with logopenic Primary Progressive Aphasia

Author

Touroutoglou, Alexandra, primary, Katsumi, Yuta, additional, Jones, Amelia, additional, Hochberg, Daisy, additional, Quimby, Megan, additional, Wong, Bonnie, additional, Carvalho, Nicole, additional, Brickhouse, Michael, additional, Dickerson, Brad C., additional, and Eldaief, Mark C., additional

Published
2023
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16. Courage in Care Planning: Advance Care Planning Readiness in the Context of COVID19 for Caregivers of Individuals Living with Dementia

Author

Brandt, Katherine, primary, Quimby, Megan, additional, Wong, Bonnie, additional, Quintiliani, Lisa M., additional, Marchesano, Amy, additional, Howe, Inola, additional, Paasche‐Orlow, Michael K., additional, Krahn, Erin, additional, Krivensky, Samantha, additional, O’Chander, Raseeka, additional, Volandes, Angelo, additional, and Dickerson, Brad C., additional

Published
2022
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22. Case Study 2: A 60-Year-Old Man With Progressive Deficits in Language Output

Author

Thurin, Kristina, primary, Patel, Viharkumar, additional, Perez, David L., additional, Dickerson, Bradford C., additional, Hochberg, Daisy, additional, Quimby, Megan, additional, Miller, Michael B., additional, Feany, Mel, additional, Silbersweig, David, additional, McGinnis, Scott M., additional, Daffner, Kirk R., additional, and Gale, Seth A., additional

Published
2022
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30. Feasibility of multidisciplinary telehealth evaluations in atypical dementia

Author

Wong, Bonnie, primary, Loyer, Emmaleigh, additional, Sullivan, Courtney, additional, Krivensky, Samantha, additional, Lopez, Angela Villareyna, additional, Quimby, Megan, additional, Hochberg, Daisy, additional, Dev, Sheena Isha, additional, Putcha, Deepti, additional, Eldaief, Mark C, additional, Brandt, Katie, additional, and Dickerson, Brad C., additional

Published
2021
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31. Courage in care planning: Advanced care planning readiness in caregivers of individuals living with dementia

Author

Brandt, Katherine, primary, Quimby, Megan, additional, Wong, Bonnie, additional, Quintiliani, Lisa M, additional, Marchesano, Amy, additional, Howe, Inola, additional, Paasche‐Orlow, Michael K, additional, Krahn, Erin, additional, Krivensky, Samantha, additional, O’Chander, Raseeka, additional, Dickerson, Brad C, additional, and Volandes, Angelo, additional

Published
2021
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32. 18F‐Flortaucipir PET imaging compared with autopsy in a clinically and pathologically heterogeneous group of patients with neurodegenerative dementias

Author

McGinnis, Scott M., primary, Touroutoglou, Alexandra, additional, Eckbo, Ryan, additional, Brickhouse, Michael, additional, Quimby, Megan, additional, Wong, Bonnie, additional, Frosch, Matthew P., additional, Gomperts, Stephen, additional, Johnson, Keith A., additional, and Dickerson, Brad C., additional

Published
2021
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34. Anterior dorsal attention network tau drives visual attention deficits in posterior cortical atrophy.

Author

Katsumi, Yuta, Putcha, Deepti, Eckbo, Ryan, Wong, Bonnie, Quimby, Megan, McGinnis, Scott, Touroutoglou, Alexandra, and Dickerson, Bradford C

Subjects
LARGE-scale brain networks, CEREBRAL atrophy, TAU proteins, NEUROFIBRILLARY tangles, ALZHEIMER'S disease, CHRONIC traumatic encephalopathy, CEREBRAL cortex
Abstract

Posterior cortical atrophy (PCA), usually an atypical clinical syndrome of Alzheimer's disease, has well-characterized patterns of cortical atrophy and tau deposition that are distinct from typical amnestic presentations of Alzheimer's disease. However, the mechanisms underlying the cortical spread of tau in PCA remain unclear. Here, in a sample of 17 biomarker-confirmed (A+/T+/N+) individuals with PCA, we sought to identify functional networks with heightened vulnerability to tau pathology by examining the cortical distribution of elevated tau as measured by 18F-flortaucipir (FTP) PET. We then assessed the relationship between network-specific FTP uptake and visuospatial cognitive task performance. As predicted, we found consistent and prominent localization of tau pathology in the dorsal attention network and visual network of the cerebral cortex. Elevated FTP uptake within the dorsal attention network (particularly the ratio of FTP uptake between the anterior and posterior nodes) was associated with poorer visuospatial attention in PCA; associations were also identified in other functional networks, although to a weaker degree. Furthermore, using functional MRI data collected from each patient at wakeful rest, we found that a greater anterior-to-posterior ratio in FTP uptake was associated with stronger intrinsic functional connectivity between anterior and posterior nodes of the dorsal attention network. Taken together, we conclude that our cross-sectional marker of anterior-to-posterior FTP ratio could indicate tau propagation from posterior to anterior dorsal attention network nodes, and that this anterior progression occurs in relation to intrinsic functional connectivity within this network critical for visuospatial attention. Our findings help to clarify the spatiotemporal pattern of tau propagation in relation to visuospatial cognitive decline and highlight the key role of the dorsal attention network in the disease progression of PCA. [ABSTRACT FROM AUTHOR]

Published
2023
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35. A category-selective semantic memory deficit for animate objects in semantic variant primary progressive aphasia

Author

Henderson, Shalom K, primary, Dev, Sheena I, additional, Ezzo, Rania, additional, Quimby, Megan, additional, Wong, Bonnie, additional, Brickhouse, Michael, additional, Hochberg, Daisy, additional, Touroutoglou, Alexandra, additional, Dickerson, Bradford C, additional, Cordella, Claire, additional, and Collins, Jessica A, additional

Published
2021
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36. Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia

Author

Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Gallée, Jeanne, Cordella, Claire, Fedorenko, Evelina, Hochberg, Daisy, Touroutoglou, Alexandra, Quimby, Megan, Dickerson, Bradford C., Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Gallée, Jeanne, Cordella, Claire, Fedorenko, Evelina, Hochberg, Daisy, Touroutoglou, Alexandra, Quimby, Megan, and Dickerson, Bradford C.

Abstract

“Functional communication” refers to an individual’s ability to communicate effectively in his or her everyday environment, and thus is a paramount skill to monitor and target therapeutically in people with aphasia. However, traditional controlled-paradigm assessments commonly used in both research and clinical settings often fail to adequately capture this ability. In the current study, facets of functional communication were measured from picture-elicited speech samples from 70 individuals with mild primary progressive aphasia (PPA), including the three variants, and 31 age-matched controls. Building upon methods recently used by Berube et al. (2019), we measured the informativeness of speech by quantifying the content of each patient’s description that was relevant to a picture relative to the total amount of speech they produced. Importantly, form-based errors, such as mispronunciations of words, unusual word choices, or grammatical mistakes are not penalized in this approach. We found that the relative informativeness, or efficiency, of speech was preserved in non-fluent variant PPA patients as compared with controls, whereas the logopenic and semantic variant PPA patients produced significantly less informative output. Furthermore, reduced informativeness in the semantic variant is attributable to a lower production of content units and a propensity for self-referential tangents, whereas for the logopenic variant, a lower production of content units and relatively ”empty” speech and false starts contribute to this reduction. These findings demonstrate that functional communication impairment does not uniformly affect all the PPA variants and highlight the utility of naturalistic speech analysis for measuring the breakdown of functional communication in PPA.

Published
2021

37. Psychosocial Stressors and Adaptive Coping Strategies in Couples After a Diagnosis of Young-Onset Dementia

Author

Bannon, Sarah M, primary, Reichman, Mira, additional, Popok, Paula, additional, Grunberg, Victoria A, additional, Traeger, Lara, additional, Gates, Melissa V, additional, Krahn, Erin A, additional, Brandt, Katherine, additional, Quimby, Megan, additional, Wong, Bonnie, additional, Dickerson, Bradford C, additional, and Vranceanu, Ana-Maria, additional

Published
2021
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42. Neuropsychological, clinico‐pathologic, neuroimaging, and biomarker profiles of the MGH FTD Unit posterior cortical atrophy (PCA) cohort

Author

Wong, Bonnie, primary, McGinnis, Scott, additional, Putcha, Deepti, additional, Dev, Sheena Isha, additional, Lucente, Diane E., additional, Quimby, Megan, additional, Brandt, Katie, additional, Eldaief, Mark C., additional, Sherman, Janet C., additional, Frosch, Matthew P., additional, and Dickerson, Brad C., additional

Published
2020
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43. Psychosocial Stressors and Adaptive Coping Strategies in Couples After a Diagnosis of Young-Onset Dementia.

Author

Bannon, Sarah M, Reichman, Mira, Popok, Paula, Grunberg, Victoria A, Traeger, Lara, Gates, Melissa V, Krahn, Erin A, Brandt, Katherine, Quimby, Megan, Wong, Bonnie, Dickerson, Bradford C, and Vranceanu, Ana-Maria

Subjects
DIAGNOSIS of dementia, CAREGIVERS, SOCIAL support, INTERVIEWING, DEMENTIA patients, SPOUSES, CONCEPTUAL structures, AGE factors in disease, HEALTH behavior, INTERPROFESSIONAL relations, RESEARCH funding, PSYCHOLOGICAL adaptation, PSYCHOLOGICAL stress, BEHAVIOR modification, HEALTH self-care
Abstract

Background and Objectives Diagnoses of young-onset dementias (YODs) are devastating for persons with dementia and spousal caregivers yet limited work has examined both partners' perceptions of challenges and coping after diagnosis. This qualitative study investigated the psychosocial stressors and adaptive coping strategies in couples diagnosed with YOD to inform the development of psychosocial support resources. Research Design and Methods We conducted live video dyadic interviews with couples (persons with YOD and spousal caregivers together; N = 23 couples). We transcribed interviews and coded data based on a hybrid deductive–inductive approach, with the structure of the coding framework informed by the stress and coping framework, and all codes derived from the data. We derived themes and subthemes related to psychosocial stressors and adaptive coping. Results We identified 5 themes related to psychosocial stressors: the impact of diagnosis, social and family relationships, changing roles and responsibilities, planning for an uncertain future, and couple communication and relationship strain. We identified 7 themes related to adaptive coping strategies: processing emotions and cultivating acceptance, promoting normalcy, efforts to preserve persons with YOD's independence and identity, collaborative and open communication, social support, meaning-making, humor, and positivity, and lifestyle changes and self-care. Discussion and Implications We replicated several themes regarding stressors and adaptive coping strategies from prior YOD research and identified novel themes and subthemes related to dyadic stressors, sources of couples' relationship strain, and the ways in which couples effectively cope with YOD. Findings inform the development of dyadic interventions to reduce YOD-related distress for both persons with dementia and spousal caregivers. [ABSTRACT FROM AUTHOR]

Published
2022
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50. P3-413: MRI-DERIVED CORTICAL ATROPHY PATTERNS AS PROBABILISTIC PREDICTORS OF SPECIFIC NEURODEGENERATIVE PATHOLOGIES

Author

Brickhouse, Michael, primary, Flaherty, Ryn, additional, Getchell, Katelynn, additional, Krahn, Erin, additional, Delp, Taylor, additional, O'Chander, Raseeka, additional, Krivensky, Samantha, additional, Zaitsev, Alexander, additional, Brandt, Katie, additional, Kim, Shalom, additional, Cordella, Claire, additional, Dev, Sheena, additional, Touroutoglou, Alexandra, additional, Putcha, Deepti, additional, Wong, Bonnie, additional, Quimby, Megan, additional, Hochberg, Daisy, additional, Eldaief, Mark C., additional, McGinnis, Scott M., additional, Frosch, Matthew P., additional, Collins, Jessica A., additional, and Dickerson, Brad C., additional

Published
2019
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