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1. Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure

Author

Chen, Qian, Perales, Celia, Soria, María Eugenia, García-Cehic, Damir, Gregori, Josep, Rodríguez-Frías, Francisco, Buti, María, Crespo, Javier, Calleja, José Luis, Tabernero, David, Vila, Marta, Lázaro, Fernando, Rando-Segura, Ariadna, Nieto-Aponte, Leonardo, Llorens-Revull, Meritxell, Cortese, Maria Francesca, Fernandez-Alonso, Irati, Castellote, José, Niubó, Jordi, Imaz, Arkaitz, Xiol, Xavier, Castells, Lluís, Riveiro-Barciela, Mar, Llaneras, Jordi, Navarro, Jordi, Vargas-Blasco, Víctor, Augustin, Salvador, Conde, Isabel, Rubín, Ángel, Prieto, Martín, Torras, Xavier, Margall, Nuria, Forns, Xavier, Mariño, Zoe, Lens, Sabela, Bonacci, Martin, Pérez-del-Pulgar, Sofía, Londoño, Maria Carlota, García-Buey, María Luisa, Sanz-Cameno, Paloma, Morillas, Rosa, Martró, Elisa, Saludes, Verónica, Masnou-Ridaura, Helena, Salmerón, Javier, Quíles, Rosa, Carrión, José Antonio, Forné, Montserrat, Rosinach, Mercè, Fernández, Inmaculada, García-Samaniego, Javier, Madejón, Antonio, Castillo-Grau, Pilar, López-Núñez, Carme, Ferri, María José, Durández, Rosa, Sáez-Royuela, Federico, Diago, Moisés, Gimeno, Concepción, Medina, Rafael, Buenestado, Juan, Bernet, Albert, Turnes, Juan, Trigo-Daporta, Matilde, Hernández-Guerra, Manuel, Delgado-Blanco, Manuel, Cañizares, Angelina, Arenas, Juan Ignacio, Gomez-Alonso, Maria Juana, Rodríguez, Manuel, Deig, Elisabet, Olivé, Gemma, Río, Oscar del, Cabezas, Joaquín, Quiñones, Ildefonso, Roget, Mercè, Montoliu, Silvia, García-Costa, Juan, Force, Lluís, Blanch, Silvia, Miralbés, Miguel, López-de-Goicoechea, María José, García-Flores, Angels, Saumoy, María, Casanovas, Teresa, Baliellas, Carme, Gilabert, Pau, Martin-Cardona, Albert, Roca, Rosa, Barenys, Mercè, Villaverde, Joana, Salord, Silvia, Camps, Blau, Silvan di Yacovo, María, Ocaña, Imma, Sauleda, Silvia, Bes, Marta, Carbonell, Judit, Vargas-Accarino, Elena, Ruzo, Sofía P., Guerrero-Murillo, Mercedes, Von Massow, Georg, Costafreda, María Isabel, López, Rosa Maria, González-Moreno, Leticia, Real, Yolanda, Acero-Fernández, Doroteo, Viroles, Silvia, Pamplona, Xavier, Cairó, Mireia, Ocete, María Dolores, Macías-Sánchez, José Francisco, Estébanez, Angel, Quer, Joan Carles, Mena-de-Cea, Álvaro, Otero, Alejandra, Castro-Iglesias, Ángeles, Suárez, Francisco, Vázquez, Ángeles, Vieito, David, López-Calvo, Soledad, Vázquez-Rodríguez, Pilar, Martínez-Cerezo, Francisco José, Rodríguez, Raúl, Macenlle, Ramiro, Cachero, Alba, Mereish, Gasshan, Mora-Moruny, Carme, Fábregas, Silvia, Sacristán, Begoña, Albillos, Agustín, Sánchez-Ruano, Juan José, Baluja-Pino, Raquel, Fernández-Fernández, Javier, González-Portela, Carlos, García-Martin, Carmen, Sánchez-Antolín, Gloria, Andrade, Raúl Jesús, Simón, Miguel Angel, Pascasio, Juan Manuel, Romero-Gómez, Manolo, Antonio del-Campo, José, Domingo, Esteban, Esteban, Rafael, Esteban, Juan Ignacio, and Quer, Josep

Published
2020
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2. MicroRNAs as Potential Graft Rejection or Tolerance Biomarkers and Their Dilemma in Clinical Routines Behaving like Devilish, Angelic, or Frightening Elements

Author

Legaz, Isabel, primary, Jimenez-Coll, Víctor, additional, González-López, Rosana, additional, Fernández-González, Marina, additional, Alegría-Marcos, María José, additional, Galián, José Antonio, additional, Botella, Carmen, additional, Moya-Quiles, Rosa, additional, Muro-Pérez, Manuel, additional, Minguela, Alfredo, additional, Llorente, Santiago, additional, and Muro, Manuel, additional

Published
2024
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3. Impact of comorbidities on patient outcomes after interferon-free therapy-induced viral eradication in hepatitis C

Author

Ampuero, Javier, Jimeno, Carlota, Quiles, Rosa, Rosales, José Miguel, Llerena, Susana, Palomo, Nieves, Cordero, Patricia, Serrano, Francisco Javier, Urquijo, Juan José, Moreno-Planas, José María, Ontanilla, Guillermo, Hernández, Marta, Ortega-Alonso, Aída, Maraver, Marta, Bonacci, Martín, Rojas, Ángela, Figueruela, Blanca, Forns, Xavier, Andrade, Raúl J., Calleja, José Luis, Diago, Moisés, Carmona, Isabel, de la Mata, Manuel, Buti, María, Crespo, Javier, Pascasio, Juan Manuel, Navarro, José María, Salmerón, Javier, and Romero-Gómez, Manuel

Published
2018
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15. Intervención comunitaria con mujeres en el ámbito de la salud mental: un proyecto de promoción de la salud y colaboración intersectorial en el barrio de Carrús (Elche)

Author

Ferrer-Aracil, Javier, Quirant-Quiles, Rosa, Paredes-Boj, Desirée, Álamo-Candelaria, Jose Manuel, Díaz-Muñoz, Luis F., Universidad de Alicante. Departamento de Trabajo Social y Servicios Sociales, and Grupo de Investigación sobre Trabajo Social y Servicios Sociales (GITSS)

Subjects
Salud mental, Trabajo Social y Servicios Sociales, Health assets, Mental health, Women, Activos para la salud, Mujeres
Abstract

En el presente artículo exponemos los resultados obtenidos en un proyecto de salud mental comunitaria de 1 año de duración llevado a cabo en el municipio de Elche (Alicante) con mujeres en situación de vulnerabilidad, que presentaban trastornos emocionales leves o moderados, autoestima y sociabilidad bajas, así como dificultad en la gestión de su propia vida. La metodología empleada fue participativa, a través de dinámica de grupos con enfoque comunitario. La experiencia fue valorada positivamente por las participantes y las organizaciones involucradas, evidenciando que el abordaje de la salud debe ir más allá de lo individual e implicar a la comunidad. This article presents the results of a one-year community mental health project carried out in the municipality of Elche (Alicante) with women in vulnerable situations, who presented mild or moderate emotional disorders, low self-esteem and sociability, as well as difficulty in managing their own life. The methodology used was participatory by means of group dynamics with a community focus. The experience was positively rated by the participants and organisations involved, showing that the approach to health must go beyond the individual and involve the entire community.

Published
2018

16. THU-124-Efficacy and safety of glecaprevir/pibrentasvir for the pangenotypic treatment of chronic hepatitis C in former intravenous drug users: Subanalysis from a Spanish real-world cohort (Hepa-C)

Author

Puigvehí, Marc, primary, Albillos, Agustin, additional, Viu, Ana, additional, Hernandez-Guerra, Manuel, additional, Vázquez, Inmaculada Fernández, additional, Prieto, M, additional, Torras, Xavier, additional, Zabal, Jose Miguel Rosales, additional, Santamaria, Lourdes Grande, additional, Morillas, Rosa, additional, Diago, Moises, additional, Morón, Beatriz de Cuenca, additional, Delgado, Manuel, additional, Bonet, Lucia, additional, Turnés, Juan, additional, Crespo, Javier, additional, Baliellas, Carme, additional, Calleja Panero, José Luis, additional, Badia-Aranda, Esther, additional, Pascasio, Juan Manuel, additional, Moreno, Jose María, additional, Monterde, Vanesa Bernal, additional, Carmona, Isabel, additional, Fernandez-Bermejo, Miguel, additional, Quiles, Rosa, additional, Garcia, Pablo Bellot, additional, Gonzalez-Santiago, Jesus M, additional, Gutierrez, Maria Luisa, additional, Moreno, José Juan, additional, Conejero, M Dolores Anton, additional, Vega, Juan De la, additional, Escudero-García, Desamparados, additional, Arenas, Juan, additional, and Carrión, Jose A., additional

Published
2019
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17. Intervención comunitaria con mujeres en el ámbito de la salud mental: un proyecto de promoción de la salud y colaboración intersectorial en el barrio de Carrús (Elche)

Author

Universidad de Alicante. Departamento de Trabajo Social y Servicios Sociales, Ferrer-Aracil, Javier, Quirant-Quiles, Rosa, Paredes-Boj, Desirée, Álamo-Candelaria, Jose Manuel, Díaz-Muñoz, Luis F., Universidad de Alicante. Departamento de Trabajo Social y Servicios Sociales, Ferrer-Aracil, Javier, Quirant-Quiles, Rosa, Paredes-Boj, Desirée, Álamo-Candelaria, Jose Manuel, and Díaz-Muñoz, Luis F.

Abstract

En el presente artículo exponemos los resultados obtenidos en un proyecto de salud mental comunitaria de 1 año de duración llevado a cabo en el municipio de Elche (Alicante) con mujeres en situación de vulnerabilidad, que presentaban trastornos emocionales leves o moderados, autoestima y sociabilidad bajas, así como dificultad en la gestión de su propia vida. La metodología empleada fue participativa, a través de dinámica de grupos con enfoque comunitario. La experiencia fue valorada positivamente por las participantes y las organizaciones involucradas, evidenciando que el abordaje de la salud debe ir más allá de lo individual e implicar a la comunidad., This article presents the results of a one-year community mental health project carried out in the municipality of Elche (Alicante) with women in vulnerable situations, who presented mild or moderate emotional disorders, low self-esteem and sociability, as well as difficulty in managing their own life. The methodology used was participatory by means of group dynamics with a community focus. The experience was positively rated by the participants and organisations involved, showing that the approach to health must go beyond the individual and involve the entire community.

Published
2018

19. R248G cystic fibrosis transmembrane conductance regulator mutation in three siblings presenting with recurrent acute pancreatitis and reproductive issues: a case series

Author

Villalona, Seiichi, primary, Glover-López, Guillermo, additional, Ortega-García, Juan Antonio, additional, Moya-Quiles, Rosa, additional, Mondejar-López, Pedro, additional, Martínez-Romero, Maria C., additional, Rigabert-Montiel, Mariano, additional, Pastor-Vivero, María D., additional, and Sánchez-Solís, Manuel, additional

Published
2017
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20. Natural killer receptors on CD8 T cells and natural killer cells from different HLA-C phenotypes in melanoma patients

Author

Campillo, Antonio, Martínez-Escribano, Jorge, Moya-Quiles, Rosa, Marín, Luis, Muro, Manuel, Guerra Pérez, Natalia, Parrado, Antonio, Campos, Matilde, Frías, José, Minguela, Alfredo, García-Alonso, Ana, Álvarez-López, Rocío, Campillo, Antonio, Martínez-Escribano, Jorge, Moya-Quiles, Rosa, Marín, Luis, Muro, Manuel, Guerra Pérez, Natalia, Parrado, Antonio, Campos, Matilde, Frías, José, Minguela, Alfredo, García-Alonso, Ana, and Álvarez-López, Rocío

Abstract

Purpose: Because immune mechanisms involved in cutaneous melanoma have not been fully elucidated, efforts have been made to achieve prognosis markers and potential targets for immune therapies, but they have not been entirely fruitful thus far. Therefore, the goal of this study was to investigate the involvement of early changes in CD8 T cells and CD56 natural killer (NK) cells expressing NK receptors in different HLA-C dimorphism groups of melanoma patients. Experimental Design: CD8 T cells and CD56 NK cells were analyzed in 41 patients and 39 sex- and age-matched controls with different HLA-C genotypes by flow cytometry. HLA-C dimorphism at position 80 was tested by PCR sequence-specific primers and PCR sequence-specific oligonucleotide to examine whether it could mediate in the emergence of cells expressing killer cell immunoglobulin-like receptors. Results: Thirty-five of 41 patients had benign sentinel node, and showed an imbalance in the absolute number of CD8+DR+ or CD8+CD161+ peripheral blood T cells according to the CD28 coexpression compared with controls. CD8+CD28−CD158a+ T and CD56+CD158a+ NK cells were significantly increased in HLA-CLys80 homozygous nonmetastatic patients, whereas only CD56+CD158a+ NK cells increased in heterozygous ones. An up-regulation of the CD158a KIR receptor was also seen on NK cells but not in T cells of patients at advanced disease stages. Conclusions: This work provides, for the first time, evidence of immune activation in early stages of cutaneous melanoma, together with an increase of cells expressing CD158a in patients bearing the corresponding HLA-C ligand, which may be important to evaluate the disease progression and to use individualized immune therapeutic approaches., Depto. de Genética, Fisiología y Microbiología, Fac. de Ciencias Biológicas, TRUE, pub

Published
2006

21. Plasma Ribavirin Trough Concentrations During Treatment of Chronic Hepatitis C in Genotype-1 Patients

Author

de-Rueda, Paloma Muñoz-, primary, Ruiz-Extremera, Angeles, additional, Candel, Jose M., additional, Quiles, Rosa, additional, Martín, Ana Belen, additional, Diago, Moises, additional, Andrade, Raul, additional, Navarro, Jose M., additional, Gila, Ana, additional, León, Josefa, additional, Carazo, Angel, additional, Quintero, Dolores, additional, and Salmerón, Javier, additional

Published
2012
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22. Gender-related invasion differences associated with mRNA expression levels of melatonin membrane receptors in colorectal cancer

Author

León, Josefa, primary, Casado, Jorge, additional, Carazo, Ángel, additional, Sanjuán, Laura, additional, Maté, Ana, additional, Muñoz de Rueda, Paloma, additional, de la Cueva, Paloma, additional, Quiles, Rosa, additional, Ruíz, Sergio, additional, Ruíz-Extremera, Ángela, additional, and Salmerón, Javier, additional

Published
2011
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23. Importance of Host Genetic Factors HLA and IL28B as Predictors of Response to Pegylated Interferon and Ribavirin

Author

de Rueda, Paloma Muñoz, primary, López-Nevot, Miguel-Ángel, additional, Sáenz-López, Pablo, additional, Casado, Jorge, additional, Martín-Casares, Antonia, additional, Palomares, Pablo, additional, Quiles, Rosa, additional, Gila, Ana, additional, Romero-Gómez, Manuel, additional, Pavón, Esther-José, additional, Muñoz, José-Antonio, additional, Carazo, Ángel, additional, Sanz-Cameno, Paloma, additional, Moreno-Otero, Ricardo, additional, Diago, Moisés, additional, León, Josefa, additional, Ruiz-Extremera, Ángeles, additional, and Salmerón, Javier, additional

Published
2011
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25. HLA class I and class II frequencies in patients with cutaneous malignant melanoma from southeastern Spain: the role of HLA-C in disease prognosis

Author

Campillo, José A., primary, Martínez-Escribano, Jorge A., additional, Muro, Manuel, additional, Moya-Quiles, Rosa, additional, Marín, Luis A., additional, Montes-Ares, Olga, additional, Guerra, Natalia, additional, Sánchez-Pedreño, Paloma, additional, Frías, José F., additional, Lozano, José A., additional, García-Alonso, Ana M., additional, and Álvarez-López, M. Rocío, additional

Published
2005
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26. Charlson Comorbidity Index predicts the overall benefit of IFN-free therapy in hepatitis (HepCom Study)

Author

Ampuero, Javier, Jimeno, Carlota, Quiles, Rosa, Palomo, Nieves, Ontanilla, Guillermo, Rosales-Zabal, Jose Miguel, Llerena, Susana, Cordero, Patricia, Serrano, Francisco Javier, Ortega, A., Hernandez, Marta, Bonacci, Martin S., Diago, Moises, Figueruela, Blanca, Forns, Xavier, Calleja, Jose L., Andrade, Raul J., La Mata, Manuel, Carmona, Isabel, Crespo, Javier, Navarro, J. M., Pascasio, Juan Manuel, Buti, Maria, Salmeron, Javier, and Manuel Romero-Gómez

27. Effectiveness and safety of first-generation protease inhibitors in clinical practice: Hepatitis C virus patients with advanced fibrosis.

Author

Salmerón J, Vinaixa C, Berenguer R, Pascasio JM, Sánchez Ruano JJ, Serra MÁ, Gila A, Diago M, Romero-Gómez M, Navarro JM, Testillano M, Fernández C, Espinosa D, Carmona I, Pons JA, Jorquera F, Rodriguez FJ, Pérez R, Montero JL, Granados R, Fernández M, Martín AB, Muñoz de Rueda P, and Quiles R

Subjects
Adult, Antiviral Agents adverse effects, Biomarkers blood, Carrier Proteins metabolism, Drug Therapy, Combination, Female, Hepacivirus enzymology, Hepacivirus genetics, Hepatitis C, Chronic complications, Hepatitis C, Chronic diagnosis, Humans, Intention to Treat Analysis, Intracellular Signaling Peptides and Proteins, Liver Cirrhosis diagnosis, Liver Cirrhosis virology, Male, Middle Aged, Prospective Studies, Protease Inhibitors adverse effects, RNA, Viral blood, Recurrence, Registries, Spain, Time Factors, Treatment Outcome, Viral Load, Viral Nonstructural Proteins metabolism, Antiviral Agents therapeutic use, Carrier Proteins antagonists & inhibitors, Hepacivirus drug effects, Hepatitis C, Chronic drug therapy, Liver Cirrhosis drug therapy, Protease Inhibitors therapeutic use, Viral Nonstructural Proteins antagonists & inhibitors
Abstract

Aim: To evaluates the effectiveness and safety of the first generation, NS3/4A protease inhibitors (PIs) in clinical practice against chronic C virus, especially in patients with advanced fibrosis., Methods: Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1, treatment-naïve (TN) or treatment-experienced (TE), who underwent triple therapy with the first generation NS3/4A protease inhibitors, boceprevir (BOC) and telaprevir (TVR), in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow up., Results: One thousand and fifty seven patients were included, 405 (38%) were treated with BOC and 652 (62%) with TVR. Of this total, 30% (n = 319) were TN and the remaining were TE: 28% (n = 298) relapsers, 12% (n = 123) partial responders (PR), 25% (n = 260) null-responders (NR) and for 5% (n = 57) with prior response unknown. The rate of sustained virologic response (SVR) by intention-to-treatment (ITT) was greater in those treated with TVR (65%) than in those treated with BOC (52%) (P < 0.0001), whereas by modified intention-to-treatment (mITT) no were found significant differences. By degree of fibrosis, 56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients, both TN and TE. In the analysis by groups, the TN patients treated with TVR by ITT showed a higher SVR (P = 0.005). However, by mITT there were no significant differences between BOC and TVR. In the multivariate analysis by mITT, the significant SVR factors were relapsers, IL28B CC and non-F4; the type of treatment (BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients, treated with BOC (46%) or with TVR (45%). 28% of the patients interrupted the treatment, mainly by non-viral response (51%): this outcome was more frequent in the TE than in the TN patients (57% vs 40%, P = 0.01). With respect to severe haematological disorders, neutropaenia was more likely to affect the patients treated with BOC (33% vs 20%, P ≤ 0.0001), and thrombocytopaenia and anaemia, the F4 patients (P = 0.000, P = 0.025, respectively)., Conclusion: In a real clinical practice setting with a high proportion of patients with advanced fibrosis, effectiveness of first-generation PIs was high except for NR patients, with similar SVR rates being achieved by BOC and TVR.

Published
2015
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28. Plasma ribavirin trough concentrations during treatment of chronic hepatitis C in genotype-1 patients.

Author

Muñoz-de-Rueda P, Ruiz-Extremera A, Candel JM, Quiles R, Martín AB, Diago M, Andrade R, Navarro JM, Gila A, León J, Carazo A, Quintero D, and Salmerón J

Subjects
Adult, Antiviral Agents administration & dosage, Antiviral Agents therapeutic use, Cohort Studies, Drug Monitoring methods, Drug Therapy, Combination, Female, Genotype, Hepacivirus isolation & purification, Hepatitis C, Chronic virology, Humans, Interferon-alpha administration & dosage, Interferon-alpha therapeutic use, Male, Middle Aged, Polyethylene Glycols administration & dosage, Polyethylene Glycols therapeutic use, Prospective Studies, Recombinant Proteins administration & dosage, Recombinant Proteins therapeutic use, Ribavirin administration & dosage, Ribavirin therapeutic use, Time Factors, Antiviral Agents pharmacokinetics, Hepacivirus genetics, Hepatitis C, Chronic drug therapy, Ribavirin pharmacokinetics
Abstract

Goals: To investigate the correlation between virological response and plasma ribavirin trough concentrations (RBV Ctrough) during the full period of chronic hepatitis C (CHC) treatment., Study: Multicenter prospective cohort study. Total 119 patients with CHC genotype-1 were treated with peginterferon alfa-2a (pegIFN) and RBV for 48 weeks. RBV quantification was carried out at week 4 (W4), W8, W12, W16, W24, W32, and W40 of treatment., Results: The mean RBV Ctrough value during treatment was 2.5±0.9 mg/L in total patients. At no time point of treatment were patients with RBV Ctrough average correlated with early and sustained virological response (SVR), but those with RBV Ctrough ≥5 mg/L (95th percentile) at any time point (22/119, 18%) were correlated with SVR (P=0.02). Such high RBV Ctrough values were found from the second to the fourth months of treatment in 73% of these patients (16/22), and this was independently associated with SVR (odds ratio=3.6, 95% confidence interval:1.02-13.2, P=0.04)., Conclusion: Our data do not support RBV plasma monitoring as a tool to optimize treatment in patients with CHC genotype-1, but show that a high RBV plasma concentration could improve SVR rates.

Published
2012
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