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Photometric studies of the type SU UMa dwarf nova NY Her were made during 2017 and 2020 at the Crimean Astrophysical Observatory and at the Sanglokh Observatory over a total of 77 nights. These observations covered two superoutbursts, four normal outbursts, and the quiescent state between them. In 2017 the supercycle was 62 days, and the cycle, 13-14 days. Positive superhumps with an average period of 0.07594 days and a variable amplitude not exceeding 0m.15 were observed during the superoutbursts. In the quiescent state between outbursts, as well as in the ascending and descending branches of the normal outbursts, negative superhumps with an average period of 0.071269 days were recorded. Their amplitude ranged over 0m.3-1m.5 in the quiescent state. The period of the negative superhumps manifested cyclical increases between normal outbursts, which is consistent with the prediction of a cyclical change in the radius of the accretion disk in terms of the thermal-tidal theory of the instability.

Skeletal muscle has attracted attention as endocrine organ, because exercise-dependent cytokines called myokines/exerkines are released from skeletal muscle and are involved in systemic functions. While, local mechanical loading to skeletal muscle by exercise or resistance training alters myofiber type and size and myonuclear number. Skeletal muscle-resident stem cells, known as muscle satellite cells (MuSCs), are responsible for the increased number of myonuclei. Under steady conditions, MuSCs are maintained in a mitotically quiescent state but exit from that state and start to proliferate in response to high physical activity. Alterations in MuSC behavior occur when myofibers are damaged, but the lethal damage to myofibers does not seem to evoke mechanical loading-dependent MuSC activation and proliferation. Given that MuSCs proliferate without damage, it is unclear how the different behaviors of MuSCs are controlled by different physical activities. Recent studies demonstrated that myonuclear number reflects the size of myofibers; hence, it is crucial to know the properties of MuSCs and the mechanism of myonuclear accretion by MuSCs. In addition, the elucidation of mechanical load-dependent changes in muscle resident cells, including MuSCs, will be necessary for the discovery of new myokines/exerkines and understating skeletal muscle diseases.

The vast majority of binaries containing a compact object and a regular star spend most of their time in a quiescent state where no strong interactions occur between components. Detection of these binaries is extremely challenging and only few candidates have been detected through optical spectroscopy. Self-lensing represents a new means of detecting compact objects in binaries, where gravitational lensing of the light from the visible component by the compact object produces periodic optical flares. Here we show that current and planned large-area optical surveys can detect a significant number ($\sim 100$-$10,000$s) of these self-lensing binaries and provide insights into the properties of the compact lenses. We show that many of the predicted population of observable self-lensing binaries will be observed with multiple self-lensing flares; this both improves the chances of detection and also immediately distinguishes them from chance-alignment micro-lensing events. Through self-lensing we can investigate long - but previously hidden - stages of binary evolution and consequently provide new constraints on evolutionary models which impact on the number and nature of double compact object mergers., 11 pages, 6 figures, 3 tables

The accretion behaviour in low-mass X-ray binaries (LMXBs) at low luminosities, especially at 3500 km/s), which could indicate that it results from an outflow such as a pulsar wind. By studying several epochs of X-ray and near-UV data obtained with XMM-Newton, we find no clear indication that the emission in the two wavebands is connected. Moreover, the luminosity ratio of Lx/Luv >100 is much higher than that observed from neutron star LMXBs that exhibit low-level accretion in quiescence. Taken together, this suggests that the UV and X-ray emission of EXO 0748-676 may have different origins, and that thermal emission from crust-cooling of the neutron star, rather than ongoing low-level accretion, may be dominating the observed quiescent X-ray flux evolution of this LMXB., Comment: 10 pages, 1 table, 4 figures, published in MNRAS. This arXiv version includes the changes described in the paper erratum

The field potentials, i.e., the electrical-potentials of the deep brain stimulations (DBS) and microelectrode signal recordings of STN-neurons flanking DBS leads canister bright to proffer functional and empirical retort or titrating therapeutic-surgical-DBSDBS. Nonetheless, predictable square (conservative) DBS leadelectrodes amid four cylindrical macro/electrodes (for macrostimulations) likely under-sample the spatial circulation of sinks and sources in a given area of the brain. This study gives the exploration of the power-spectral-density (PSD) and spatial-feature dimensions of LFP-activity in primate subthalamicnuclei (STN/or s-nuclei) and globus pallidus internus (GPi) by means of unendingly 32embedded-channel directional DBS-array-electrodes. The waveforms of s-nuclei and GPi were acquired as of directional-DBS-micro electrode-arrays in the latent or quiescent state and in a reach-and-retrieval task in twoprimates in adolescent, naive and immature (raw) animal Parkinson conditions. The potentials of signal acquisitions recordings were evaluated amongst bipolar-pairs of micro electrodes using personage and agglomerative (bunched) electrode configurations, with the latter mimicking the cylindrical macro electrode (for macro stimulations) arrangements/specifications employed in the present - current clinical settings of field-potentials signal acquisition. Signal recordings from these DBS-electrodes shown that, b -oscillatory frequency fluctuations have spatial-finger-prints in s-nuclei and GPi, and that these fluctuations were muted when clustering the electrode contacts together to create cylindrical macro electrodes alike in parallel and in relative dimension to those employed clinically and diagnostically. Furthermore, these atlases depend on parkinsonian condition and whether the subject was quiescent or performing a motor-task. With this research work the development of future adaptive closed-loop (ACL) DBS-therapies to rely on fieldpoten

Photometric studies of the SU UMa-type dwarf nova IRXS J161659.5+620014 have been made on the 2.6-m and 1.25-m telescopes at the Crimean Astrophysical Observatory during 2017 and 2018 in the quiescent state of the system, during normal outbursts, and during superoutbursts. It is found that the interval between adjacent normal outbursts was about 11 days during 2017. Observations in the quiescent state during 2017 yielded an orbital period of 0.06888(2) days. Observations during 2018 manifested good reproducibility of the characteristics of the superoutbursts compared to those of previous years. A refined period of 0.071044(15) days was obtained for the positive superhumps in stage “C” and their color indices were determined.

© 2020 Elsevier Inc. Quiescence is a state of reversible proliferative arrest in which cells are not actively dividing and yet retain the capacity to reenter the cell cycle upon receiving an appropriate stimulus. In this review, Marescal and Cheeseman explore the diversity of quiescent cells and highlight the unifying characteristics that define the quiescent state., NIH/National Institute of General Medical Sciences (Grant R35GM126930)

Tissue regeneration declines with ageing but little is known about whether this arises from changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two quiescent stem-cell states distinguished by relative CD34 expression: CD34High, with stemness properties (genuine state), and CD34Low, committed to myogenic differentiation (primed state). The genuine-quiescent state is unexpectedly preserved into later life, succumbing only in extreme old age due to the acquisition of primed-state traits. Niche-derived IGF1-dependent Akt activation debilitates the genuine stem-cell state by imposing primed-state features via FoxO inhibition. Interventions to neutralize Akt and promote FoxO activity drive a primed-to-genuine state conversion, whereas FoxO inactivation deteriorates the genuine state at a young age, causing regenerative failure of muscle, as occurs in geriatric mice. These findings reveal transcriptional determinants of stem-cell heterogeneity that resist ageing more than previously anticipated and are only lost in extreme old age, with implications for the repair of geriatric muscle., The authors acknowledge funding from MINECO-Spain (grant no. RTI2018-096068), ERC2016-AdG-741966, LaCaixa-HEALTH-HR17-00040, MDA, UPGRADE-H2020-825825, AFM and DPP-Spain to P.M.-C; María-de-Maeztu-Program for Units of Excellence to UPF (grant no. MDM-2014-0370) and the Severo-Ochoa-Program for Centers of Excellence to CNIC (grant no. SEV-2015-0505). This work was also supported by NIAMS IRP through NIH grants nos AR041126 and AR041164 to V.S. and utilized computational resources of the NIH HPC Biowulf cluster (http://hpc.nih.gov); ASI, Ricerca Finalizzata, Ateneo Sapienza to A.M.; AIRC (grant no. 23257); ASI (grant no. MARS-PRE, DC-VUM-2017-006); H2020-MSCA-RISE-2014 (645648) to M.S. and a FNR core grant (grant no. C15/BM/10397420) to A.d.S. L.G.P. was partially supported by an FPI fellowship and an EMBO fellowship (grant no. ALTF 420-2017); and S.C., X.H. and V.M. by FI, Severo-Ochoa and PFI Fellowships (Spain), respectively.

Neural stem cells (NSCs) actively proliferate and generate neurons and glial cells (active state) in the embryonic brain, whereas they are mostly dormant (quiescent state) in the adult brain. The expression dynamics of Hes1 are different between active and quiescent NSCs. In active NSCs, Hes1 expression oscillates and periodically represses the expression of proneural genes such as Ascl1, thereby driving their oscillations. By contrast, in quiescent NSCs, Hes1 oscillations maintain expression at higher levels even at trough phases (thus continuous), thereby continuously suppressing proneural gene expression. High levels of Hes1 expression and the resultant suppression of Ascl1 promote the quiescent state of NSCs, whereas oscillatory Hes1 expression and the resultant oscillatory Ascl1 expression regulate their active state. Furthermore, in other developmental contexts, high, continuous Hes1 expression induces astrocyte differentiation or the formation of boundaries, which function as signaling centers. Thus, the expression dynamics of Hes1 are a key regulatory mechanism generating and maintaining various cell types in the nervous system.

Radiotherapy is one of the most common treatments for oral cancer. However, in the clinic, recurrence and metastasis of oral cancer occur after radiotherapy, and the underlying mechanism remains unclear. Cancer stem cells (CSCs), considered the “seeds” of cancer, have been confirmed to be in a quiescent state in most established tumours, with their innate radioresistance helping them survive more easily when exposed to radiation than differentiated cancer cells. There is increasing evidence that CSCs play an important role in recurrence and metastasis post-radiotherapy in many cancers. However, little is known about how oral CSCs cause tumour recurrence and metastasis post-radiotherapy. In this review article, we will first summarise methods for the identification of oral CSCs and then focus on the characteristics of a CSC subpopulation induced by radiation, hereafter referred to as “awakened” CSCs, to highlight their response to radiotherapy and potential role in tumour recurrence and metastasis post-radiotherapy as well as potential therapeutics targeting CSCs. In addition, we explore potential therapeutic strategies targeting these “awakened” CSCs to solve the serious clinical challenges of recurrence and metastasis in oral cancer after radiotherapy.

El hígado es uno de los principales órganos encargados de mantener la homeostasis en vertebrados, además de poseer una gran capacidad regenerativa. El hígado está constituido por diversos tipos celulares que de forma coordinada contribuyen para que el órgano funcione eficientemente. Los hepatocitos representan el tipo celular principal de este órgano y llevan a cabo la mayoría de sus actividades; además, constituyen una población heterogénea de células epiteliales con funciones especializadas en el metabolismo. El fenotipo de los hepatocitos está controlado por diferentes vías de señalización, como la vía del TGFβ/Smads, la ruta Hippo/YAP-TAZ y la vía Wnt/β-catenina, entre otras. Los hepatocitos son células que se encuentran normalmente en un estado quiescente, aunque cuentan con una plasticidad intrínseca que se manifiesta en respuesta a diversos daños en el hígado; así, estas células reactivan su capacidad proliferativa o cambian su fenotipo a través de procesos celulares como la transdiferenciación o la transformación, para contribuir a mantener la homeostasis del órgano en condiciones saludables o desarrollar diversas patologías.

Neural stem cells (NSCs) are multipotent progenitors that are responsible for producing all of the neurons and macroglia in the nervous system. In adult mammals, NSCs reside predominantly in a mitotically dormant, quiescent state, but they can proliferate in response to environmental inputs such as feeding or exercise. It is hoped that quiescent NSCs could be activated therapeutically to contribute towards repair in humans. This will require an understanding of quiescent NSC heterogeneities and regulation during normal physiology and following brain injury. Non-mammalian vertebrates (zebrafish and salamanders) and invertebrates (Drosophila) offer insights into brain repair and quiescence regulation that are difficult to obtain using rodent models alone. We review conceptual progress from these various models, a first step towards harnessing quiescent NSCs for therapeutic purposes.

By showing that there is no any memristor in the integer-order Hindmarsh–Rose (H–R) model, the slow ion channel is remodeled by a fractional-order memristor, where the fractional-order derivative is related to the memory effect and the decay rate of the ion current. Then a fractional-order memristive (FOM) H–R model without equilibrium is proposed. Due to a small parameter, the FOM H–R model is a fast–slow system which can be taken as the small perturbation system of the fast subsystem. By Lyapunov direct method, the boundedness of the fast subsystem is proved. With the help of the boundedness and stability of the fast system, the hidden dynamics of the FOM H–R model is discussed. As the small parameter is fixed, it is shown that the membrane potential of the FOM H–R model limits to a quiescent state as the fractional order is less than 0.5 and limits to a periodic spiking as the fractional order is greater than 0.5 less than 1. Without the constraint of the small parameter, the periodic and chaotic bursting appears in the FOM H–R model, which implies the small parameter makes the membrane potential activity simpler. It can be drawn a conclusion that the ion current with the slow decay rate can inhibit the neurons.

To generate sufficient numbers of transplantable haematopoietic stem cells (HSCs) in vitro, a detailed understanding of how this process takes place in vivo is essential. The endothelial-to-haematopoietic transition (EHT), which culminates in the production of the first HSCs, is a highly complex process during which key regulators are switched on and off at precise moments and which is embedded into a myriad of microenvironmental signals from surrounding cells and tissues. We have previously demonstrated an HSC-supportive function for Gata3 within the sympathetic nervous system and the sub-aortic mesenchyme, but show here that it also plays a cell-intrinsic role during the EHT. It is expressed in haemogenic endothelial cells and early HSC precursors, where its expression correlates with a more quiescent state. Importantly, endothelial-specific deletion of Gata3 shows that it is functionally required for these cells to mature into HSCs, placing Gata3 at the core of the EHT regulatory network.

Overview: Long-term survival of T lymphocytes in quiescent state is essential to maintain their cell numbers in secondary lymphoid organs and in peripheral circulation. In the BioBreeding diabetes-prone strain of rats (BB-DP), loss of functional GIMAP5 (GTPase of the immune associated nucleotide binding protein 5) results in profound peripheral T lymphopenia. This discovery heralded the identification of a new family of proteins initially called Immune-associated nucleotide binding protein (IAN) family. In this review we will use ‘GIMAP’ to refer to this family of proteins. Recent studies suggest that GIMAP proteins may interact with each other and also be involved in the movement of the cellular cargo along the cytoskeletal network. Here we will summarize the current knowledge on the characteristics and functions of GIMAP family of proteins.