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29 results on '"Queliza, Karen"'

1. Gastrointestinal Hemorrhage: A Manifestation of the Telomere Biology Disorders

Author

Himes, Ryan W., Chiou, Eric H., Queliza, Karen, Shouval, Dror S., Somech, Raz, Agarwal, Suneet, Jajoo, Kunal, Ziegler, David S., Kratz, Christian P., Huang, James, Lucas, Tiffany L., Myers, Kasiani C., Nelson, Adam S., DiNardo, Courtney D., Alter, Blanche P., Giri, Neelam, Khincha, Payal P., McReynolds, Lisa J., Dufour, Carlo, Pierri, Filomena, Goldman, Frederick D., Sherif, Youmna, Savage, Sharon A., Miloh, Tamir, and Bertuch, Alison A.

Published
2021
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2. Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children

Author

Nicholson, Maribeth R., Mitchell, Paul D., Alexander, Erin, Ballal, Sonia, Bartlett, Mark, Becker, Penny, Davidovics, Zev, Docktor, Michael, Dole, Michael, Felix, Grace, Gisser, Jonathan, Hourigan, Suchitra K., Jensen, M. Kyle, Kaplan, Jess L., Kelsen, Judith, Kennedy, Melissa, Khanna, Sahil, Knackstedt, Elizabeth, Leier, McKenzie, Lewis, Jeffery, Lodarek, Ashley, Michail, Sonia, Oliva-Hemker, Maria, Patton, Tiffany, Queliza, Karen, Russell, George H., Singh, Namita, Solomon, Aliza, Suskind, David L., Werlin, Steven, Kellermayer, Richard, and Kahn, Stacy A.

Published
2020
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7. Fecal Microbiota Transplantation Commonly Failed in Children With Co-Morbidities

Author

Kellermayer, Richard, primary, Wu, Qinglong, additional, Nagy-Szakal, Dorottya, additional, Queliza, Karen, additional, Ihekweazu, Faith D., additional, Bocchini, Claire E., additional, Magee, Abria R., additional, Oezguen, Numan, additional, Spinler, Jennifer K., additional, Hollister, Emily B., additional, Shulman, Robert J., additional, Versalovic, James, additional, Luna, Ruth Ann, additional, and Savidge, Tor C., additional

Published
2021
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10. Maternal Lactobacillus reuteri supplementation shifts the intestinal microbiome in mice and provides protection from experimental colitis in female offspring.

Author

Krishna, Mahesh, Engevik, Melinda, Queliza, Karen, Britto, Savini, Shah, Rajesh, Ruan, Wenly, Wang, Hongtao, Versalovic, James, and Kellermayer, Richard

Subjects
LACTOBACILLUS reuteri, COLITIS, INFLAMMATORY bowel diseases, PROBIOTICS, MAMMALS
Abstract

The purpose of our experiment was to explore how stochastic (inter‐individual variation) gut microbiome composition may link to inflammatory bowel disease (IBD) susceptibility and guide the development of a perinatal preventative probiotic. Dextran sodium sulfate (DSS) was introduced to C57BL/BJ mice to induce acute colitis as a model of IBD. Potentially protective bacteria were identified using a discovery‐validation cohort approach toward stochastic DSS susceptibility. Lactobacilli (two different cocktails of L. reuteri and L. johnsonii strains) or control media were supplemented by mouth to dams prior to delivery and during lactation (i.e., perinatal probiotic). The pups were evaluated for DSS susceptibility at young adulthood. Fecal Lactobacillus was increased in the DSS‐resistant mice in both the discovery and validation cohorts. Maternal supplementation of female offspring with an L. reuteri cocktail (strains 6798‐1, 6798‐jm, and 6798‐cm) induced progressive microbiome separation and protection against colitis by young adulthood. Maternal supplementation of L. reuteri could confer protection against DSS colitis in young adult female mice. This work is the first to exploit stochastic mammalian microbiome variation to guide microbial therapeutic identification. Our findings underscore neonatal microbiome plasticity and set the stage for the potential development of perinatally deliverable protective probiotics against human IBD. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Bacteroides ovatus ATCC 8483 monotherapy is superior to traditional fecal transplant and multi-strain bacteriotherapy in a murine colitis model

Author

Ihekweazu, Faith D., primary, Fofanova, Tatiana Y., additional, Queliza, Karen, additional, Nagy-Szakal, Dorottya, additional, Stewart, Christopher J., additional, Engevik, Melinda A., additional, Hulten, Kristina G., additional, Tatevian, Nina, additional, Graham, David Y., additional, Versalovic, James, additional, Petrosino, Joseph F., additional, and Kellermayer, Richard, additional

Published
2019
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18. 2092 A multicenter study of fecal microbiota transplantation for Clostridium difficile infection in children

Author

Nicholson, Maribeth R., primary, Alexander, Erin, additional, Bartlett, Mark, additional, Becker, Penny, additional, Davidovics, Zev, additional, Knackstedt, Elizabeth E., additional, Docktor, Michael, additional, Dole, Michael, additional, Felix, Grace, additional, Gisser, Jonathan, additional, Hourigan, Suchitra, additional, Jensen, Kyle, additional, Kaplan, Jess, additional, Kelsen, Judith, additional, Kennedy, Melissa, additional, Khanna, Sahil, additional, Leier, McKenzie, additional, Lewis, Jeffery, additional, Lodarek, Ashley, additional, Michail, Sonia, additional, Mitchell, Paul, additional, Oliva‐Hemker, Maria, additional, Patton, Tiffany, additional, Queliza, Karen, additional, Singh, Namita, additional, Solomon, Aliza, additional, Suskind, David, additional, Werlin, Steven, additional, Kellermayer, Richard, additional, and Kahn, Stacy, additional

Published
2018
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20. Tu1847 - Bacteroides Ovatus Monotherapy is Sufficient to Suppress Intestinal Inflammation in a Murine Colitis Model

Author

Ihekweazu, Faith D., primary, Fofanova, Tatiana, additional, Queliza, Karen, additional, Nagy-Szakal, Dorottya, additional, Stewart, Christopher, additional, Engevik, Melinda A., additional, Hulten, Kristina, additional, Tatevian, Nina, additional, Graham, David Y., additional, Versalovic, James, additional, Petrosino, Joseph F., additional, and Kellermayer, Richard, additional

Published
2018
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21. Sa2016 - Fecal Microbiota Transplantation for Clostridium Difficile in Patients with Inflammatory Bowel Disease; the Pediatric Perspective

Author

Nicholson, Maribeth R., primary, Alexander, Erin, additional, Ballal, Sonia, additional, Bartlett, Mark, additional, Becker, Penny, additional, Davidovics, Zev, additional, Doby, Elizabeth, additional, Docktor, Michael, additional, Dole, Michael, additional, Felix, Grace, additional, Gisser, Jonathan, additional, Hourigan, Suchitra K., additional, Jensen, M.K., additional, Kaplan, Jess, additional, Kelsen, Judith R., additional, Kennedy, Melissa, additional, Khanna, Sahil, additional, Leier, McKenzie, additional, Lewis, Jeffery D., additional, Lodarek, Ashley, additional, Michail, Sonia, additional, Mitchell, Paul, additional, Oliva-Hemker, Maria, additional, Patton, Tiffany, additional, Queliza, Karen, additional, Singh, Namita, additional, Suskind, David, additional, Solomon, Aliza, additional, Werlin, Steven, additional, Kellermayer, Richard, additional, and Kahn, Stacy A., additional

Published
2018
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25. Microbiome and Metabolome Responses to Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection in Pediatric Patients

Author

Kellermayer, Richard, primary, Balderas, Miriam, additional, Nagy-Szakal, Dorottya, additional, Luna, Ruth Ann, additional, Ihekweazu, Faith, additional, Queliza, Karen, additional, Bocchini, Claire, additional, Spinler, Jennifer, additional, Oezguen, Numan, additional, Shulman, Robert J., additional, Versalovic, James, additional, and Savidge, Tor C., additional

Published
2017
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26. Bacteroides ovatusATCC 8483 monotherapy is superior to traditional fecal transplant and multi-strain bacteriotherapy in a murine colitis model

Author

Ihekweazu, Faith D., Fofanova, Tatiana Y., Queliza, Karen, Nagy-Szakal, Dorottya, Stewart, Christopher J., Engevik, Melinda A., Hulten, Kristina G., Tatevian, Nina, Graham, David Y., Versalovic, James, Petrosino, Joseph F., and Kellermayer, Richard

Abstract

ABSTRACTBackground and aimsBacteriotherapy aimed at addressing dysbiosis may be therapeutic for Inflammatory Bowel Diseases (IBDs). We sought to determine if defined Bacteroides-based bacteriotherapy could be an effective and consistent alternative to fecal microbiota transplantation (FMT) in a murine model of IBD.MethodsWe induced experimental colitis in 8– 12-week-old C57BL/6 mice using 2–3% dextran sodium sulfate. Mice were simultaneously treated by oral gavage with a triple-Bacteroidescocktail, individual Bacteroidesstrains, FMT using stool from healthy donor mice, or their own stool as a control. Survival, weight loss and markers of inflammation (histology, serum amyloid A, cytokine production) were correlated to 16S rRNAgene profiling of fecal and mucosal microbiomes.ResultsTriple-Bacteroidescombination therapy was more protective against weight loss and mortality than traditional FMT therapy. B. ovatusATCC8483 was more effective than any individual strain, or a combination of strains, in preventing weight loss, decreasing histological damage, dampening inflammatory response, and stimulating epithelial recovery. Irrespective of the treatment group, overall Bacteroidesabundance associated with treatment success and decreased cytokine production while the presence of Akkermansiacorrelated with treatment failure. However, the therapeutic benefit associated with high Bacteroidesabundance was negated in the presence of Streptococcus.ConclusionsBacteroides ovatusmonotherapy was more consistent and effective than traditional FMT at ameliorating colitis and stimulating epithelial recovery in a murine model of IBD. Given the tolerability of Bacteroides ovatusATCC 8483 in an active, on-going human study, this therapy may be repurposed for the management of IBD in a clinically expedient timeline.

Published
2019
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29. Efficacy and Outcomes of Faecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection in Children with Inflammatory Bowel Disease.

Author

Nicholson MR, Alexander E, Ballal S, Davidovics Z, Docktor M, Dole M, Gisser JM, Goyal A, Hourigan SK, Jensen MK, Kaplan JL, Kellermayer R, Kelsen JR, Kennedy MA, Khanna S, Knackstedt ED, Lentine J, Lewis JD, Michail S, Mitchell PD, Oliva-Hemker M, Patton T, Queliza K, Sidhu S, Solomon AB, Suskind DL, Weatherly M, Werlin S, de Zoeten EF, and Kahn SA

Subjects
Adult, Child, Chronic Disease, Fecal Microbiota Transplantation adverse effects, Feces, Humans, Recurrence, Treatment Outcome, Clostridioides difficile, Clostridium Infections complications, Clostridium Infections therapy, Inflammatory Bowel Diseases complications, Inflammatory Bowel Diseases therapy
Abstract

Background: Children with inflammatory bowel disease [IBD] are disproportionally affected by recurrent Clostridioides difficile infection [rCDI]. Although faecal microbiota transplantation [FMT] has been used with good efficacy in adults with IBD, little is known about outcomes associated with FMT in paediatric IBD., Methods: We performed a retrospective review of FMT at 20 paediatric centres in the USA from March 2012 to March 2020. Children with and without IBD were compared with determined differences in the efficacy of FMT for rCDI. In addition, children with IBD with and without a successful outcome were compared with determined predictors of success. Safety data and IBD-specific outcomes were obtained., Results: A total of 396 paediatric patients, including 148 with IBD, were included. Children with IBD were no less likely to have a successful first FMT then the non-IBD affected cohort [76% vs 81%, p = 0.17]. Among children with IBD, patients were more likely to have a successful FMT if they received FMT with fresh stool [p = 0.03], were without diarrhoea prior to FMT [p = 0.03], or had a shorter time from rCDI diagnosis until FMT [p = 0.04]. Children with a failed FMT were more likely to have clinically active IBD post-FMT [p = 0.002] and 19 [13%] patients had an IBD-related hospitalisation in the 3-month follow-up., Conclusions: Based on the findings from this large US multicentre cohort, the efficacy of FMT for the treatment of rCDI did not differ in children with IBD. Failed FMT among children with IBD was possibly related to the presence of clinically active IBD., (© The Author(s) 2021. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2022
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