1. MiR-200c-3p expression may be associated with worsening of the clinical course of patients with COVID-19.
- Author
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Pimenta R, Viana NI, Dos Santos GA, Candido P, Guimarães VR, Romão P, Silva IA, de Camargo JA, Hatanaka DM, Queiroz PGS, Teruya A, Echenique L, Besen BAMP, Leite KRM, Srougi V, Srougi M, and Reis ST
- Abstract
COVID-19 represents a public health emergency, whose mechanism of which is not fully understood. It is speculated that microRNAs may play a crucial role in host cells after infection by SARS-CoV-2. Thus, our study aimed to analyze the expression of miR-200c-3p in saliva samples from patients with COVID-19. One handred eleven samples from patients with COVID-19 were divided into 4 groups. Group I: 39 patients negative for Covid-19; Group II: 37 positive and symptomatic patients, with no indication of hospitalization; Group III: 21 patients with respiratory disorders (hospitalized); Group IV: 14 patients with severe conditions (oxygen therapy). The expression levels of miR-200c-3p were determined using qPCR. We found greater expression of miR-200c-3p in patients in group IV ( p <0.0001), and also verified that patients aged ≥42 years had a higher expression of this miR ( p =0.013). Logistic regression analysis revealed that the expression of miR-200c-3p and systemic arterial hypertension are factors independently associated with patients in group IV ( p <0.0001). Our results suggest that miR-200c-3p is a predictor of severity independent of COVID-19 risk factors, which could represent a way of screening patients affected by SARS-CoV-2., Competing Interests: The authors declare that they have no conflict of interests.
- Published
- 2021
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