Search

Your search keyword '"Queiros Ana C"' showing total 8 results
Start Over Author "Queiros Ana C"

Refine your results

more »

more »
8 results on '"Queiros Ana C"'

1. Active regulatory T-cells contribute to broadened T-cell repertoire diversity in ivIg-treated SLE patients

Author

Costa Nuno, Pires Ana E, Gabriel Ana M, Goulart Luiz F, Pereira Clara, Leal Barbara, Queiros Ana C, Chaara Wahiba, Moraes-Fontes Maria F, Vasconcelos Carlos, Ferreira Carlos, Martins Jorge, Bastos Marina, Santos Maria J, Pereira Maria A, Martins Berta, Lima Margarida, João Cristina, Six Adrien, Demengeot Jocelyne, and Fesel Constantin

Subjects
Medicine
Published
2011
Full Text
View/download PDF

2. Quantitative comparison of DNA methylation assays for biomarker development and clinical applications

Author

Bock, Christoph, Halbritter, Florian, Carmona, Francisco J, Tierling, Sascha, Datlinger, Paul, Assenov, Yassen, Berdasco, Maria, Bergmann, Anke K, Booher, Keith, Busato, Florence, Campan, Mihaela, Dahl, Christina, Dahmcke, Christina M, Diep, Dinh, Fernandez, Agustin F, Gerhauser, Clarissa, Haake, Andrea, Heilmann, Katharina, Holcomb, Thomas, Hussmann, Dianna, Ito, Mitsuteru, Klaever, Ruth, Kreutz, Martin, Kulis, Marta, Lopez, Virginia, Nair, Shalima S, Paul, Dirk S, Plongthongkum, Nongluk, Qu, Wenjia, Queiros, Ana C, Reinicke, Frank, Sauter, Guido, Schlomm, Thorsten, Statham, Aaron, Stirzaker, Clare, Strogantsev, Ruslan, Urdinguio, Rocio G, Walter, Kimberly, Weichenhan, Dieter, Weisenberger, Daniel J, Beck, Stephan, Clark, Susan J, Esteller, Manel, Ferguson-Smith, Anne C, Fraga, Mario F, Guldberg, Per, Hansen, Lise Lotte, Laird, Peter W, Martin-Subero, Jose I, Nygren, Anders OH, Peist, Ralf, Plass, Christoph, Shames, David S, Siebert, Reiner, Sun, Xueguang, Tost, Jorg, Walter, Joern, and Zhang, Kun

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Genetics, Algorithms, DNA, DNA Methylation, DNA Modification Methylases, Genetic Markers, High-Throughput Nucleotide Sequencing, High-Throughput Screening Assays, Promoter Regions, Genetic, Reproducibility of Results, Sensitivity and Specificity, BLUEPRINT consortium
Abstract

DNA methylation patterns are altered in numerous diseases and often correlate with clinically relevant information such as disease subtypes, prognosis and drug response. With suitable assays and after validation in large cohorts, such associations can be exploited for clinical diagnostics and personalized treatment decisions. Here we describe the results of a community-wide benchmarking study comparing the performance of all widely used methods for DNA methylation analysis that are compatible with routine clinical use. We shipped 32 reference samples to 18 laboratories in seven different countries. Researchers in those laboratories collectively contributed 21 locus-specific assays for an average of 27 predefined genomic regions, as well as six global assays. We evaluated assay sensitivity on low-input samples and assessed the assays' ability to discriminate between cell types. Good agreement was observed across all tested methods, with amplicon bisulfite sequencing and bisulfite pyrosequencing showing the best all-round performance. Our technology comparison can inform the selection, optimization and use of DNA methylation assays in large-scale validation studies, biomarker development and clinical diagnostics.

Published
2016

3. Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cells

Author

Costa, Nuno, Pires, Ana E., Gabriel, Ana M., Goulart, Luiz F., Pereira, Clara, Leal, Bárbara, Queiros, Ana C., Chaara, Wahiba, Moraes-Fontes, Maria F., Vasconcelos, Carlos, Ferreira, Carlos, Martins, Jorge, Bastos, Marina, Santos, Maria J., Pereira, Maria A., Martins, Berta, Lima, Margarida, João, Cristina, Six, Adrien, Demengeot, Jocelyne, and Fesel, Constantin

Published
2013
Full Text
View/download PDF

4. The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome

Author

Duran-Ferrer, Marti, Clot, Guillem, Nadeu, Ferran, Beekman, Renee, Baumann, Tycho, Nordlund, Jessica, Marincevic-Zuniga, Yanara, Lönnerholm, Gudmar, Rivas-Delgado, Alfredo, Martin, Silvia, Ordonez, Raquel, Castellano, Giancarlo, Kulis, Marta, Queiros, Ana C., Lee, Seung-Tae, Wiemels, Joseph, Royo, Romina, Puiggros, Montserrat, Lu, Junyan, Gine, Eva, Bea, Silvia, Jares, Pedro, Agirre, Xabier, Prosper, Felipe, Lopez-Otin, Carlos, Puente, Xose S., Oakes, Christopher C., Zenz, Thorsten, Delgado, Julio, Lopez-Guillermo, Armando, Campo, Elias, Ignacio Martin-Subero, Jose, Duran-Ferrer, Marti, Clot, Guillem, Nadeu, Ferran, Beekman, Renee, Baumann, Tycho, Nordlund, Jessica, Marincevic-Zuniga, Yanara, Lönnerholm, Gudmar, Rivas-Delgado, Alfredo, Martin, Silvia, Ordonez, Raquel, Castellano, Giancarlo, Kulis, Marta, Queiros, Ana C., Lee, Seung-Tae, Wiemels, Joseph, Royo, Romina, Puiggros, Montserrat, Lu, Junyan, Gine, Eva, Bea, Silvia, Jares, Pedro, Agirre, Xabier, Prosper, Felipe, Lopez-Otin, Carlos, Puente, Xose S., Oakes, Christopher C., Zenz, Thorsten, Delgado, Julio, Lopez-Guillermo, Armando, Campo, Elias, and Ignacio Martin-Subero, Jose

Abstract

We report a systematic analysis of the DNA methylation variability in 1,595 samples of normal cell subpopulations and 14 tumor subtypes spanning the entire human B-cell lineage. Differential methylation among tumor entities relates to differences in cellular origin and to de novo epigenetic alterations, which allowed us to build an accurate machine learning-based diagnostic algorithm. We identify extensive individual-specific methylation variability in silenced chromatin associated with the proliferative history of normal and neoplastic B cells. Mitotic activity generally leaves both hyper- and hypomethylation imprints, but some B-cell neoplasms preferentially gain or lose DNA methylation. We construct a DNA-methylation-based mitotic clock, called epiCMIT, whose lapse magnitude represents a strong independent prognostic variable in B-cell tumors and is associated with particular driver genetic alterations. Our findings reveal DNA methylation as a holistic tracer of B-cell tumor developmental history, with implications in differential diagnosis and the prediction of clinical outcome. Martin-Subero and colleagues analyze DNA methylation patterns in B-cell tumors and their normal cells of origin, and develop epiCMIT, a methylation-based mitotic clock with prognostic relevance.

Published
2020
Full Text
View/download PDF

5. DNA methylation profiles in chronic lymphocytic leukemia patients treated with chemoimmunotherapy

Author

Tsagiopoulou, Maria, Papakonstantinou, Nikos, Moysiadis, Theodoros, Mansouri, Larry, Ljungström, Viktor, Duran-Ferrer, Marti, Malousi, Andigoni, Queiros, Ana C., Plevova, Karla, Bhoi, Sujata, Kollia, Panagoula, Oscier, David, Anagnostopoulos, Achilles, Trentin, Livio, Ritgen, Matthias, Pospisilova, Sarka, Stavroyianni, Niki, Ghia, Paolo, Martin-Subero, Jose I., Pott, Christiane, Rosenquist, Richard, Stamatopoulos, Kostas, Tsagiopoulou, Maria, Papakonstantinou, Nikos, Moysiadis, Theodoros, Mansouri, Larry, Ljungström, Viktor, Duran-Ferrer, Marti, Malousi, Andigoni, Queiros, Ana C., Plevova, Karla, Bhoi, Sujata, Kollia, Panagoula, Oscier, David, Anagnostopoulos, Achilles, Trentin, Livio, Ritgen, Matthias, Pospisilova, Sarka, Stavroyianni, Niki, Ghia, Paolo, Martin-Subero, Jose I., Pott, Christiane, Rosenquist, Richard, and Stamatopoulos, Kostas

Abstract

Background: In order to gain insight into the contribution of DNA methylation to disease progression of chronic lymphocytic leukemia (CLL), using 450K Illumina arrays, we determined the DNA methylation profiles in paired pre-treatment/relapse samples from 34 CLL patients treated with chemoimmunotherapy, mostly (n = 31) with the fludarabine-cyclophosphamide-rituximab (FCR) regimen. Results: The extent of identified changes in CLL cells versus memory B cells from healthy donors was termed "epigenetic burden" (EB) whereas the number of changes between the pre-treatment versus the relapse sample was termed "relapse changes" (RC). Significant (p < 0.05) associations were identified between (i) high EB and short time-to-first-treatment (TTFT); and, (ii) few RCs and short time-to-relapse. Both the EB and the RC clustered in specific genomic regions and chromatin states, including regulatory regions containing binding sites of transcription factors implicated in B cell and CLL biology. Conclusions: Overall, we show that DNA methylation in CLL follows different dynamics in response to chemoimmunotherapy. These epigenetic alterations were linked with specific clinical and biological features.

Published
2019
Full Text
View/download PDF

6. Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cells

Author

Costa, Nuno, primary, Pires, Ana E., additional, Gabriel, Ana M., additional, Goulart, Luiz F., additional, Pereira, Clara, additional, Leal, Bárbara, additional, Queiros, Ana C., additional, Chaara, Wahiba, additional, Moraes-Fontes, Maria F., additional, Vasconcelos, Carlos, additional, Ferreira, Carlos, additional, Martins, Jorge, additional, Bastos, Marina, additional, Santos, Maria J., additional, Pereira, Maria A., additional, Martins, Berta, additional, Lima, Margarida, additional, João, Cristina, additional, Six, Adrien, additional, Demengeot, Jocelyne, additional, and Fesel, Constantin, additional

Published
2012
Full Text
View/download PDF

7. Characterization of the DNA Methylome during Human B-Cell Differentiation

Author

Kulis, Marta, Heath, Simon, Castellano, Giancarlo, Beekman, Renée, Merkel, Angelika, Raineri, Emanuele, Esteve, Anna, Queirós, Ana C, Clot, Guillem, Schuyler, Ronald, Ecker, Simone, Pancaldi, Vera, Rico, Daniel, Agueda, Lidia, Blanc, Julie, Richardson, David, Clarke, Laura, Datta, Avik, Russiñol, Nuria, Pascual, Marien, Aguirre, Xavier, Prosper, Felipe, Alignani, Diego, Paiva, Bruno, Caron, Gersende, Fest, Thierry, Muench, Marcus O., Fomin, Marina, Lee, Seung-Tae, Wiemels, Joseph L., Valencia, Alfonso, Gut, Marta, Flicek, Paul, Stunnenberg, Hendrik G., Siebert, Reiner, Küppers, Ralf, Gut, Ivo G., Campo, Elias, and Martín-Subero, José I.

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results