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1. Testing the efficacy and safety of BIO101, for the prevention of respiratory deterioration, in patients with COVID-19 pneumonia (COVA study): a structured summary of a study protocol for a randomised controlled trial

Author: A Azbekyan, Waly Dioh, J Mariani, Serge Camelo, René Lafont, M. Chabane, C. Tourette, Pierre J. Dilda, S. Agus, Mathilde Latil, C Morelot-Panzini, M Lins, Tony Whitehouse, Stanislas Veillet, G B Nair, L A Hajjar, Sorbonne Université (SU), Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière] (Département ' R3S '), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université - Faculté de Médecine (SU FM), Universidade de São Paulo (USP), Sint Maartenskliniek, Oakland University, Queens Elizabeth Hospital [Birmingham], Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Biosynthèse des Signaux Peptidiques [IBPS] (IBPS-BIOSIPE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Acute respiratory Distress Syndrome, medicine.medical_specialty, Letter, Randomization, [SDV]Life Sciences [q-bio], Mas receptor, Medicine (miscellaneous), Placebo, Renin Angiotensin System, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, medicine, Risk of mortality, Clinical endpoint, Pharmacology (medical), Respiratory function, 030212 general & internal medicine, Inflammation, lcsh:R5-920, business.industry, COVID-19, Interim analysis, angiotensin converting enzyme-2, BIO101, Tolerability, Emergency medicine, SARS-CoV2, 20-hydroxyecdysone, business, lcsh:Medicine (General), randomised controlled trial, 030217 neurology & neurosurgery
Abstract: Objectives As of December, 1st, 2020, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, resulted in more than 1 472 917 deaths worldwide and death toll is still increasing exponentially. Many COVID-19 infected people are asymptomatic or experience moderate symptoms and recover without medical intervention. However, older people and those with comorbid hypertension, diabetes, obesity, or heart disease are at higher risk of mortality. Because current therapeutic options for COVID-19 patients are limited specifically for this elderly population at risk, Biophytis is developing BIO101 (20-hydroxyecdysone, a Mas receptor activator) as a new treatment option for managing patients with SARS-CoV-2 infection at the severe stage. The angiotensin converting enzyme 2 (ACE2) serves as a receptor for SARS-CoV-2. Interaction between ACE2 and SARS-CoV2 spike protein seems to alter the function of ACE2, a key player in the renin-angiotensin system (RAS). The clinical picture of COVID-19 includes acute respiratory distress syndrome (ARDS), cardiomyopathy, multiorgan dysfunction and shock, all of which might result from an imbalance of the RAS. We propose that RAS balance could be restored in COVID-19 patients through MasR activation downstream of ACE2 activity, with 20-hydroxyecdysone (BIO101) a non-peptidic Mas receptor (MasR) activator. Indeed, MasR activation by 20-hydroxyecdysone harbours anti-inflammatory, anti-thrombotic, and anti-fibrotic properties. BIO101, a 97% pharmaceutical grade 20-hydroxyecdysone could then offer a new therapeutic option by improving the respiratory function and ultimately promoting survival in COVID-19 patients that develop severe forms of this devastating disease. Therefore, the objective of this COVA study is to evaluate the safety and efficacy of BIO101, whose active principle is 20-hydroxyecdysone, in COVID-19 patients with severe pneumonia. Trial design Randomized, double-blind, placebo-controlled, multi-centre, group sequential and adaptive which will be conducted in 2 parts. Part 1: Ascertain the safety and tolerability of BIO101 and obtain preliminary indication of the activity of BIO101, in preventing respiratory deterioration in the target population Part 2: Re-assessment of the sample size needed for the confirmatory part 2 and confirmation of the effect of BIO101 observed in part 1 in the target population. The study is designed as group sequential to allow an efficient run-through, from obtaining an early indication of activity to a final confirmation. And adaptive – to allow accumulation of early data and adapt sample size in part 2 in order to inform the final design of the confirmatory part of the trial. Participants Inclusion criteria Age: 45 and above A confirmed diagnosis of COVID-19 infection, within the last 14 days, prior to randomization, as determined by PCR or other approved commercial or public health assay, in a specimen as specified by the test used. Hospitalized, in observation or planned to be hospitalized due to COVID-19 infection symptoms with anticipated hospitalization duration ≥3 days With evidence of pneumonia based on all of the following: Clinical findings on a physical examination Respiratory symptoms developed within the past 7 days With evidence of respiratory decompensation that started not more than 4 days before start of study medication and present at screening, meeting one of the following criteria, as assessed by healthcare staff: Tachypnea: ≥25 breaths per minute Arterial oxygen saturation ≤92% A special note should be made if there is suspicion of COVID-19-related myocarditis or pericarditis, as the presence of these is a stratification criterion Without a significant deterioration in liver function tests: ALT and AST ≤ 5x upper limit of normal (ULN) Gamma-glutamyl transferase (GGT) ≤ 5x ULN Total bilirubin ≤ 5×ULN Willing to participate and able to sign an informed consent form (ICF). Or, when relevant, a legally authorized representative (LAR) might sign the ICF on behalf of the study participant Female participants should be: at least 5 years post-menopausal (i.e., persistent amenorrhea 5 years in the absence of an alternative medical cause) or surgically sterile; OR Have a negative urine pregnancy test at screening Be willing to use a contraceptive method as outlined in inclusion criterion 9 from screening to 30 days after last dose. Male participants who are sexually active with a female partner must agree to the use of an effective method of birth control throughout the study and until 3 months after the last administration of the investigational product. (Note: medically acceptable methods of contraception that may be used by the participant and/or partner include combined oral contraceptive, contraceptive vaginal ring, contraceptive injection, intrauterine device, etonogestrel implant, each supplemented with a condom, as well as sterilization and vasectomy). Female participants who are lactating must agree not to breastfeed during the study and up to 14 days after the intervention. Male participants must agree not to donate sperm for the purpose of reproduction throughout the study and until 3 months after the last administration of the investigational product. For France only: Being affiliated with a European Social Security. Exclusion criteria Not needing or not willing to remain in a healthcare facility during the study Moribund condition (death likely in days) or not expected to survive for >7 days – due to other and non-COVID-19 related conditions Participant on invasive mechanical ventilation via an endotracheal tube, or extracorporeal membrane oxygenation (ECMO), or high-flow Oxygen (delivery of oxygen at a flow of ≥16 L/min.). Participant is not able to take medications by mouth (as capsules or as a powder, mixed in water). Disallowed concomitant medication: Consumption of any herbal products containing 20-hydroxyecdysone and derived from Leuzea carthamoides; Cyanotis vaga or Cyanotis arachnoidea is not allowed (e.g. performance enhancing agents). Any known hypersensitivity to any of the ingredients, or excipients of the study medication, BIO101. Renal disease requiring dialysis, or known renal insufficiency (eGFR≤30 mL/min/1.73 m2, based on Cockcroft & Gault formula). In France only: Non-affiliation to compulsory French social security scheme (beneficiary or right-holder). Being under tutelage or legal guardianship. Participants will be recruited from approximately 30 clinical centres in Belgium, France, the UK, USA and Brazil. Maximum patients’ participation in the study will last 28 days. Follow-up of participants discharged from hospital will be performed through post-intervention phone calls at 14 (± 2) and 60 (± 4) days. Intervention and comparator Two treatment arms will be tested in this study: interventional arm 350 mg b.i.d. of BIO101 (AP 20-hydroxyecdysone) and placebo comparator arm 350 mg b.i.d of placebo. Administration of daily dose is the same throughout the whole treatment period. Participants will receive the study medication while hospitalized for up to 28 days or until a clinical endpoint is reached (i.e., ‘negative’ or ‘positive’ event). Participants who are officially discharged from hospital care will no longer receive study medication. Main outcomes Primary study endpoint: The proportion of participants with ‘negative’ events up to 28 days. ‘Negative’ events are defined as respiratory deterioration and all-cause mortality. For the purpose of this study, respiratory deterioration will be defined as any of the following: Requiring mechanical ventilation (including cases that will not be intubated due to resource restrictions and triage). Requiring extracorporeal membrane oxygenation (ECMO). Requiring high-flow oxygen defined as delivery of oxygen at a flow of ≥16 L/min. Only if the primary endpoint is significant at the primary final analysis the following Key secondary endpoints will be tested in that order: Proportion of participants with events of respiratory failure at Day 28 Proportion of participants with ‘positive’ events at Day 28. Proportion of participants with events of all-cause mortality at Day 28 A ‘positive’ event is defined as the official discharge from hospital care by the department due to improvement in participant condition. Secondary and exploratory endpoints: In addition, a variety of functional measures and biomarkers (including the SpO2 / FiO2 ratio, viral load and markers related to inflammation, muscles, tissue and the RAS / MAS pathways) will also be collected. Randomization Randomization is performed using an IBM clinical development IWRS system during the baseline visit. Block-permuted randomization will be used to assign eligible participants in a 1:1 ratio. In part 1, randomization will be stratified by RAS pathway modulator use (yes/no) and co-morbidities (none vs. 1 and above). In Part 2, randomization will be stratified by centre, gender, RAS pathway modulator use (yes/no), co-morbidities (none vs. 1 and above), receiving Continuous Positive Airway Pressure/Bi-level Positive Airway Pressure (CPAP/BiPAP) at study entry (Yes/No) and suspicion of COVID-19 related myocarditis or pericarditis (present or not). Blinding (masking) Participants, caregivers, and the study team assessing the outcomes are blinded to group assignment. All therapeutic units (TU), BIO101 b.i.d. or placebo b.i.d., cannot be distinguished in compliance with the double-blind process. An independent data-monitoring committee (DMC) will conduct 2 interim analyses. A first one based on the data from part 1 and a second from the data from parts 1 and 2. The first will inform about BIO101 safety, to allow the start of recruitment into part 2 followed by an analysis of the efficacy data, to obtain an indication of activity. The second interim analysis will inform about the sample size that will be required for part 2, in order to achieve adequate statistical power. Numbers to be randomised (sample size) Number of participants randomized: up to 465, in total Part 1: 50 (to obtain the proof of concept in COVID-19 patients). Part 2: 310, potentially increased by 50% (up to 465, based on interim analysis 2) (to confirm the effects of BIO101 observed in part 1). Trial Status The current protocol Version is V 10.0, dated on 24.09.2020. The recruitment that started on September 1st 2020 is ongoing and is anticipated to finish for the whole study by March2021. Trial registration The trial was registered before trial start in trial registries: EudraCT, No. 2020-001498-63, registered May 18, 2020; and Clinicaltrials.gov, identifier NCT04472728, registered July 15, 2020. Full protocol The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.
Published: 2021

2. Association of multimorbidity with higher levels of urinary incontinence: a cross-sectional study of 23 089 individuals aged ≥15 years residing in Spain

Author: Louis Jacob, Hans Oh, Ai Koyanagi, Petre Cristian Ilie, Nicola Veronese, Lee Smith, Jae Il Shin, Guillermo F. López-Sánchez, Pinar Soysal, Igor Grabovac, Jacob L., Lopez-Sanchez G.F., Oh H., Shin J.I., Grabovac I., Soysal P., Ilie P.C., Veronese N., Koyanagi A., Smith L., Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University of Murcia [Spain], University of Southern California (USC), Yonsei University College of Medicine [Séoul, Corée du Sud], Medizinische Universität Wien = Medical University of Vienna, Istanbul Faculty of Medicine, Istanbul University, Queens Elizabeth Hospital [Birmingham], Università degli studi di Palermo - University of Palermo, Catalan Institute for Research and Advanced Studies (ICREA), Institute of Environmental Science and Technology, Autonomous University of Barcelona, 08193 Bellaterra, Cerdanyola, Spain, affiliation inconnue, and Anglia Ruskin University (ARU)
Subjects: Male, multimorbidity, Cross-sectional study, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, cross-sectional studies, Urinary incontinence, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, medicine, Prevalence, Multimorbidity, Humans, 030212 general & internal medicine, Association (psychology), National health, High prevalence, urinary incontinence, business.industry, Research, Middle Aged, Cross-sectional studies, Logistic models, Multimorbidity, Spain, Urinary incontinence, Spain, Marital status, Female, medicine.symptom, Family Practice, business, logistic models, Demography
Abstract: BackgroundOne can assume a relatively high prevalence of urinary incontinence (UI) in people with multimorbidity. However, literature in this area is scarce. There is a need for further robust research to aid GPs to identify patients at a particular risk for UI, and to initiate the early treatment and multidisciplinary management of this condition.AimTo examine the association between multimorbidity and UI in 23 089 individuals aged ≥15 years and residing in Spain.Design and settingThis study used data from the Spanish National Health Survey 2017, a cross-sectional sample of 23 089 participants aged ≥15 years residing in Spain (54.1% female; mean [standard deviation] age = 53.4 [18.9] years).MethodUI and 30 other physical and mental chronic conditions were self-reported. Multimorbidity was defined as the presence of ≥2 physical and/or mental chronic conditions (excluding UI). Control variables included sex, age, marital status, education, smoking, and alcohol consumption. Multivariable logistic regression analyses were conducted to assess the association between multimorbidity and UI.ResultsThe prevalence of UI was 5.9% in this sample. UI was more frequent in the presence than in the absence of each one of the 30 chronic conditions (PPPConclusionIn this large sample of Spanish individuals aged ≥15 years, suffering from multimorbidity was associated with a significantly higher level of UI.
Published: 2020

3. Long-term outcome after living donor liver transplantation compared to donation after brain death in autoimmune liver diseases: Experience from the European Liver Transplant Registry

Author: Christophe Duvoux, Ahmet Coker, Krzysztof Zieniewicz, Seyed Ali Malek-Hosseini, Sezai Yilmaz, Arianeb Mehrabi, Melina Heinemann, Karim Boudjema, René Adam, Vincent Karam, Christoph Schramm, Peter Lodge, Darius F. Mirza, Marina Berenguer, Michael A. Heneghan, Andreas Paul, Koray Acarli, Ansgar W. Lohse, Johann Pratschke, Yaman Tokat, Jiri Fronek, Timur Liwinski, University Hospital Hamburg-Eppendorf, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Hôpital Paul Brousse, Universitat de València (UV), Queens Elizabeth Hospital [Birmingham], Shiraz University of Medical Sciences [Iran] (SUMS), King's College Hospital (KCH), Leeds Teaching Hospitals NHS Trust, Charité Campus Virchow-Klinikum (CVK), CHU Pontchaillou [Rennes], Universitätsklinikum Essen [Universität Duisburg-Essen] (Uniklinik Essen), Medical University of Warsaw - Poland, Institute for Clinical and Experimental Medicine (IKEM), University of Heidelberg, Medical Faculty, Ege university, Inönü University, CHU Henri Mondor, Astellas PharmaAstellas Pharmaceuticals, NovartisNovartis, Institut Georges Lopez, SandozNovartis, and CHU Henri Mondor [Créteil]
Subjects: Adult, Male, medicine.medical_specialty, Brain Death, Cirrhosis, Multivariate analysis, [SDV]Life Sciences [q-bio], Medizin, living donor, Disease, Autoimmune hepatitis, inflammatory, 030230 surgery, clinical research/practice, Gastroenterology, Primary sclerosing cholangitis, 03 medical and health sciences, 0302 clinical medicine, patient survival, Internal medicine, medicine, Primary Sclerosing Cholangitis, Living Donors, Immunology and Allergy, Risk-Factors, Humans, Pharmacology (medical), Registries, Child, Retrospective Studies, Transplantation, business.industry, Liver Diseases, Hazard ratio, Graft Survival, Cohort, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, medicine.disease, 3. Good health, Donation after brain death, Liver Transplantation, Treatment Outcome, 030211 gastroenterology & hepatology, immune, Morbidity, Living donor liver transplantation, business, liver disease, liver transplantation/hepatology
Abstract: Knowledge of living donor liver transplantation (LDLT) for autoimmune liver diseases (AILDs) is scarce. This study analyzed survival in LDLT recipients registered in the European Liver Transplant Registry with autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis (PSC) and the non-autoimmune disorder alcohol-related cirrhosis. In total, 29 902 individuals enrolled between 1998 and 2017 were analyzed, including 1003 with LDLT. Survival from >90 days after LDLT for AILDs in adults was 85.5%, 74.2%, and 58.0% after 5, 10, and 15 years. Adjusted for recipient age, sex, and liver transplantation era, adult PSC patients receiving LDLT showed increased mortality compared to donation after brain death (DBD) (hazard ratio [HR] = 1.95, 95% confidence interval [CI] = 1.36-2.80, p < .001). Pediatric PSC patients showed also increased mortality >90 days after LDLT compared to DBD (HR = 3.00, 95% CI 1.04-8.70, p = .043). Multivariate analysis identified several risk factors for death in adult PSC patients receiving LDLT including a male donor (HR = 2.49, p = .025). Adult PSC patients with LDLT versus DBD conferred increased mortality from disease recurrence (subdistribution hazard ratio [subHR] = 5.36, p = .001) and biliary complications (subHR = 4.40, p = .006) in multivariate analysis. While long-term outcome following LDLT for AILD is generally favorable, PSC patients with LDLT compared to DBD might be at increased risk of death., Astellas Pharma; Novartis; Institut Georges Lopez; Sandoz, The Organ Sharing Organizations: the French ABM (Sami Djabbour), the Dutch NTS (Maaike de Wolf), the Eurotransplant Foundation (Marieke Van Meel), the Spanish RETH (Gloria de la Rosa), the UK-Ireland NHSBT (Michael Daynes), and the Scanditransplant (Ilse Duus Weinreich) are acknowledged for the data cross-check and sharing with the ELTR. The European Liver Transplant Registry is supported by a grant from Astellas Pharma, Novartis, Institut Georges Lopez, and Sandoz and receives logistical support from the Paul Brousse Hospital (AP-HP).
Published: 2021

4. Response to Letter to the Editor: 'Prevention of Adrenal Crisis: Cortisol Response to Major Stress Compared to Stress Dose Hydrocortisone Delivery'

Author: David J. Smith, Christopher J Mowatt, Angela E Taylor, Sibylle Kohler, Alessandro Prete, Radu Mihai, John Komninos, Niki Karavitaki, Dimitra Vassiliadi, Mark A. Foster, Violet Fazal-Sanderson, Brian G. Keevil, Joanne L. Fallowfield, Janet M. Lord, Donna M. O'Neil, Wiebke Arlt, Irina Bancos, John A.H. Wass, Djillali Annane, Merlan, Justine, University of Birmingham [Birmingham], Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism, Nutrition, Mayo Clinic, School of Mathematics [Birmingham], Queens Elizabeth Hospital [Birmingham], Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Evangelismos Athens General Hospital, Royal Shrewsbury Hospital, Churchill Hospital Oxford Centre for Haematology, Hôpital Raymond Poincaré [AP-HP], Infection et inflammation (2I), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), and University Hospital of South Manchester
Subjects: medicine.medical_specialty, Letter to the editor, Hydrocortisone, [SDV]Life Sciences [q-bio], Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Adrenocorticotropic hormone, Biochemistry, Endocrinology, Adrenocorticotropic Hormone, Internal medicine, Humans, Medicine, Online Only Articles, ComputingMilieux_MISCELLANEOUS, business.industry, Biochemistry (medical), Letters to the Editor Responses, Adrenal crisis, [SDV] Life Sciences [q-bio], Acute Disease, Cosyntropin, medicine.symptom, business, AcademicSubjects/MED00250, Adrenal Insufficiency, medicine.drug
Abstract: International audience
Published: 2020

5. Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology

Author: Charlotte G Smith, Francesca Barone, Saba Asam, David H. Gardner, Andrew Filer, Bridget Glaysher, David Roulois, Valentina Iannizzotto, Joana Campos, Frédéric Mourcin, Jason D. Turner, Mark Coles, Christopher D. Buckley, Marvin Sylvestre, Benjamin A Fisher, Karin Tarte, Simon J. Bowman, Douglas T. Fearon, Saba Nayar, Sanjiv A. Luther, Queens Elizabeth Hospital [Birmingham], University of Birmingham [Birmingham], Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of York [York, UK], University of Cambridge [UK] (CAM), Université de Lausanne (UNIL), University Hospitals Birmingham NHS Foundation TrustWellcome Trust, WTHuman Frontier Science Program, HFSP RGP0006/2009Manchester Biomedical Research Centre, BRCUniversity of Birmingham BRC-1215-20009Ligue Contre le CancerNC/K000527/1National Institute for Health Research, NIHRArthritis Research UK G0601156, Jonchère, Laurent, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université de Lausanne = University of Lausanne (UNIL)
Subjects: 0301 basic medicine, Pathology, medicine.medical_specialty, Leukocyte migration, Stromal cell, Population, Fluorescent Antibody Technique, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Salivary Glands, Animals, Disease Models, Animal, Fibroblasts/pathology, Flow Cytometry, Humans, Interleukin-13/metabolism, Interleukins/metabolism, Lymphocytes/pathology, Mice, Salivary Glands/pathology, Tertiary Lymphoid Structures/pathology, Sjögren’s syndrome, autoimmunity, fibroblasts, tertiary lymphoid structures, 03 medical and health sciences, Paracrine signalling, 0302 clinical medicine, Immunology and Inflammation, [SDV.CAN] Life Sciences [q-bio]/Cancer, Tertiary lymphoid, medicine, Lymphocytes, Structures, Autocrine signalling, education, PDPN, education.field_of_study, Interleukin-13, Multidisciplinary, Interleukins, Biological Sciences, 030104 developmental biology, Lymphotoxin, Tertiary Lymphoid Structures, Podoplanin, PNAS Plus, 030215 immunology
Abstract: Significance TLS, which are clusters of lymphocytes and stromal cells observed at sites of chronic inflammation, play a key role in sustaining disease progression in autoimmune conditions. While the role of lymphocytes in these structures has been studied extensively, the role of fibroblasts, nonhematopoietic stromal cells, in the formation and maintenance of TLS has not been demonstrated. Here, we establish that, at sites of TLS establishment, resident fibroblasts expand and acquire immunological features in a process that is dependent on IL13 and IL22. Interference with this process or depletion of immunofibroblasts leads to involution of TLS, resulting in decreased immune-cell activation and resolution of tissue pathology, thus supporting the use of fibroblast-targeting strategies to treat TLS-associated autoimmune diseases., Resident fibroblasts at sites of infection, chronic inflammation, or cancer undergo phenotypic and functional changes to support leukocyte migration and, in some cases, aggregation into tertiary lymphoid structures (TLS). The molecular programming that shapes these changes and the functional requirements of this population in TLS development are unclear. Here, we demonstrate that external triggers at mucosal sites are able to induce the progressive differentiation of a population of podoplanin (pdpn)-positive stromal cells into a network of immunofibroblasts that are able to support the earliest phases of TLS establishment. This program of events, that precedes lymphocyte infiltration in the tissue, is mediated by paracrine and autocrine signals mainly regulated by IL13. This initial fibroblast network is expanded and stabilized, once lymphocytes are recruited, by the local production of the cytokines IL22 and lymphotoxin. Interfering with this regulated program of events or depleting the immunofibroblasts in vivo results in abrogation of local pathology, demonstrating the functional role of immunofibroblasts in supporting TLS maintenance in the tissue and suggesting novel therapeutic targets in TLS-associated diseases.
Published: 2019

6. Modified-Release Hydrocortisone in Congenital Adrenal Hyperplasia

Author: Alessandro Prete, F. Peter Treasure, Nicole Reisch, Wiebke Arlt, John Porter, Aude Brac de la Perriere, Colin Perry, Angelica Lindén Hirschberg, Richard J. Ross, Ashwini Mallappa, Philippe Touraine, Deborah P. Merke, Anders Juul, Nike M. M. L. Stikkelbroeck, Kerry Maltby, D. Aled Rees, John Newell-Price, National Institutes of Health [Bethesda] (NIH), Queens Elizabeth Hospital [Birmingham], University of Birmingham [Birmingham], Hospices Civils de Lyon (HCL), Karolinska University Hospital [Stockholm], Rigshospitalet [Copenhagen], Copenhagen University Hospital, University of Sheffield [Sheffield], Queen Elizabeth University Hospital (Glasgow), Cardiff University, University-Hospital Munich-Großhadern [München], Radboud University Medical Centre [Nijmegen, The Netherlands], Service d’endocrinologie et médecine de la reproduction [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Diurnal Ltd, and University of Cambridge [UK] (CAM)
Subjects: Male, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Anti-Inflammatory Agents, Phases of clinical research, Biochemistry, Gastroenterology, 0302 clinical medicine, Endocrinology, 030212 general & internal medicine, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], Middle Aged, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Prognosis, 3. Good health, Tolerability, Female, adrenal insufficiency, Glucocorticoid, AcademicSubjects/MED00250, medicine.drug, Cortisol secretion, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, Context (language use), 21-hydroxylase deficiency, 03 medical and health sciences, Young Adult, All institutes and research themes of the Radboud University Medical Center, Internal medicine, Adrenal insufficiency, medicine, congenital adrenal hyperplasia, Humans, Congenital adrenal hyperplasia, hydrocortisone, Online Only Articles, Clinical Research Articles, Aged, Hydrocortisone, Adrenal Hyperplasia, Congenital, business.industry, Biochemistry (medical), medicine.disease, glucocorticoid, business, Follow-Up Studies
Abstract: Context Standard glucocorticoid therapy in congenital adrenal hyperplasia (CAH) regularly fails to control androgen excess, causing glucocorticoid overexposure and poor health outcomes. Objective We investigated whether modified-release hydrocortisone (MR-HC), which mimics physiologic cortisol secretion, could improve disease control. Methods A 6-month, randomized, phase 3 study was conducted of MR-HC vs standard glucocorticoid, followed by a single-arm MR-HC extension study. Primary outcomes were change in 24-hour SD score (SDS) of androgen precursor 17-hydroxyprogesterone (17OHP) for phase 3, and efficacy, safety and tolerability of MR-HC for the extension study. Results The phase 3 study recruited 122 adult CAH patients. Although the study failed its primary outcome at 6 months, there was evidence of better biochemical control on MR-HC, with lower 17OHP SDS at 4 (P = .007) and 12 (P = .019) weeks, and between 07:00h to 15:00h (P = .044) at 6 months. The percentage of patients with controlled 09:00h serum 17OHP ( Conclusion MR-HC improved biochemical disease control in adults with reduction in steroid dose over time and patient-reported benefit.
Published: 2021

7. Pre-soaking of semitendinosus graft with vancomycin does not alter its biomechanical properties. A biomechanical in-vitro controlled study using graft from living donors Running title: Vancomycin Pre-soaking does not alter Hamstring Biomechanical Properties MD Maxime Jaubert MD

Author: Jacquet, Christophe, Jaubert, Maxime, Pioger, Charles, Sbihi, Abderahmane, Pithioux, Martine, Le Baron, Marie, Sharma, Akash, Ollivier, Matthieu, Institut du Mouvement et de l’appareil Locomoteur [Hôpital Sainte-Marguerite - APHM] (IML), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud )-Rhumatologie [Sainte- Marguerite - APHM] ( Hôpitaux Sud), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Queens Elizabeth Hospital [Birmingham], and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020

8. EACVI communication paper first international young dedicated multimodal cardiovascular imaging simulation education event organized by the ESC

Author: Erwan Donal, J. Dreyfus, Augustin Coisne, Hani Mahmoud-Elsayed, Matteo Cameli, Julia Grapsa, Tomaž Podlesnikar, Giulia Elena Mandoli, Thor Edvardsen, Théo Pezel, Stephane Lafitte, Sarah Moharem Elgamal, Johns Hopkins University (JHU), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Université Paris-Sud - Paris 11 (UP11)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Nord, Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Queens Elizabeth Hospital [Birmingham], Università degli Studi di Siena = University of Siena (UNISI), University Hospitals Bristol, National Heart Institute [Egypte] (NHI), University of Maribor, University of Ljubljana, Barts Health NHS Trust [London, UK], CHU Bordeaux [Bordeaux], Oslo University Hospital [Oslo], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Centre cardiologique du Nord (CCN), Jonchère, Laurent, Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Event (relativity), simulation-based training, MEDLINE, 030204 cardiovascular system & hematology, Multimodal Imaging, cardiac magnetic resonance, 03 medical and health sciences, 0302 clinical medicine, Medical, Medicine, Humans, echocardiography, Radiology, Nuclear Medicine and imaging, cardiovascular imaging, Communication, Europe, Societies, Medical, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, business.industry, General Medicine, medicine.disease, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Medical emergency, Cardiology and Cardiovascular Medicine, business, Cardiac magnetic resonance, Societies
Abstract: International audience
Published: 2020

9. Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebo-controlled, randomised, double blind, multi-centre study

Author: Frank Tegtmeier, Reinhard Schinzel, Ronny Beer, Diederik Bulters, Jean-Yves LeFrant, Joan Sahuquillo, Andreas Unterberg, Peter Andrews, Antonio Belli, Javier Ibanez, Alfonso Lagares, Michael Mokry, Harald Willschke, Charlotte Flüh, Erich Schmutzhard, on behalf of the NOSTRA Investigators, Vasopharm GmbH (IGZ Würzburg), Innsbruck Medical University [Austria] (IMU), Wessex Neurological Centre, Southampton General Hospital, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Vall d'Hebron University Hospital [Barcelona], UniversitätsKlinikum Heidelberg, Western General Hospital, Edinburgh, Queens Elizabeth Hospital [Birmingham], Hospital Universitario Son Espases, Hospital Universitario 12 de Octubre [Madrid], University Hospital Graz, Medizinische Universität Wien = Medical University of Vienna, University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein (UKSH), and Kiel University
Subjects: humanos, adolescente, Medicine (miscellaneous), MESH: Biopterin, Placebos, Study Protocol, Traumatic brain injury, 0302 clinical medicine, estudios prospectivos, MESH: Double-Blind Method, Pharmacology (medical), Prospective Studies, 030212 general & internal medicine, mediana edad, MESH: Treatment Outcome, Outcome, lcsh:R5-920, MESH: Middle Aged, resultado del tratamiento, Middle Aged, adulto, MESH: Case-Control Studies, 3. Good health, adulto joven, Treatment Outcome, MESH: Young Adult, MESH: Nitric Oxide Synthase, lcsh:Medicine (General), escala del coma de Glasgow, óxido nítrico sintasa, Adult, Adolescent, estudios de casos y controles, traumatismos cerebrales, MESH: Placebos, MESH: Brain Injuries, Traumatic, Randomised controlled trials, Young Adult, 03 medical and health sciences, Double-Blind Method, MESH: Glasgow Coma Scale, Humans, Glasgow Coma Scale, método con doble ocultación, MESH: Infusions, Intravenous, MESH: Adolescent, MESH: Humans, [SCCO.NEUR]Cognitive science/Neuroscience, Nitric oxide synthase inhibition, MESH: Quality of Life, MESH: Adult, Biopterin, MESH: Prospective Studies, biopterina, Brain Injuries, Case-Control Studies, calidad de vida, Quality of Life, MESH: Europe, Nitric Oxide Synthase, 030217 neurology & neurosurgery
Abstract: Background Traumatic brain injury is a leading cause of death and disability worldwide. The nitric oxide synthase inhibitor Ronopterin was shown to improve clinical outcome by enhancing neuroprotection in a phase IIa trial. Methods/design The NOSTRA phase III trial (Ronopterin in traumatic brain injury) is a multi-centre, prospective, randomised, double-blinded, placebo-controlled, phase III trial in Europe. It aims at determining whether the administration of Ronopterin compared to placebo improves neurological outcome in patients with moderate or severe traumatic brain injury at 6 months after injury. The trial is designed to recruit patients between 18 and 60 years of age with moderate or severe traumatic brain injury (Glasgow Coma Scale score >= 3) and requiring insertion of an intracranial pressure probe. Trial patients will receive a 48-h intravenous infusion of either Ronopterin or placebo starting at the earliest 6 h and at the latest 18 h after injury. The primary outcome will be the extended Glasgow Outcome Score (eGOS) at 6 months. Secondary outcomes will include the Quality of Life Index (QOLIBRI) at 6 months after the injury and the eGOS at 3 months after the injury. Additionally, effects on mortality, intracranial pressure and cerebral perfusion pressure are evaluated. Discussion The trial aims to provide evidence on the efficacy and safety of Ronopterin in patients with traumatic brain injury., The study is completely funded by vasopharm GmbH. FT and RS as employees of vasopharm were involved in the design of the study.
Published: 2020

10. mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors

Author: Antonio Daniele Pinna, Natalie Filmann, Lionel Rostaing, Jens Brockmann, Michael Heise, Andreas A. Schnitzbauer, Simone I. Strasser, Giorgio Rossi, Silvio Nadalin, Jean Gugenheim, Tom M. Ganten, Umberto Cillo, Norman M. Kneteman, Koert P. de Jong, André Roy, Víctor Sánchez Turrión, Thomas Becker, Christoph Duvoux, Markus Rentsch, Jürgen Klempnauer, Utz Settmacher, George Philippe Pageaux, Christian Klein, Roberto Troisi, Edward K. Geissler, Darius F. Mirza, Gunnar Söderdahl, Peter Neuhaus, Jan Lerut, Hans J. Schlitt, Patrizia Burra, Vincenzo Mazzaferro, Johann Pratschke, T. Scholz, Neville V. Jamieson, Wolf O. Bechstein, James Powel, Thomas Soliman, Heikki Mäkisalo, Magnus Rizell, René Adam, Bart van Hoek, Michele Colledan, Itxarone Bilbao, Philippe Bachellier, Olivier Chazoullières, Sherrie Bhoori, Jaques Pirenne, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Schnitzbauer, A, Filmann, N, Adam, R, Bachellier, P, Bechstein, W, Becker, T, Bhoori, S, Bilbao, I, Brockmann, J, Burra, P, Chazoullieres, O, Cillo, U, Colledan, M, Duvoux, C, Ganten, T, Gugenheim, J, Heise, M, van Hoek, B, Jamieson, N, de Jong, K, Klein, C, Klempnauer, J, Kneteman, N, Lerut, J, Makisalo, H, Mazzaferro, V, Mirza, D, Nadalin, S, Neuhaus, P, Pageaux, G, Pinna, A, Pirenne, J, Pratschke, J, Powel, J, Rentsch, M, Rizell, M, Rossi, G, Rostaing, L, Roy, A, Scholz, T, Settmacher, U, Soliman, T, Strasser, S, Soderdahl, G, Troisi, R, Turrion, V, Schlitt, H, Geissler, E, Universitätsklinikum Frankfurt, Centre Hépato-Biliaire [Hôpital Paul Brousse] (CHB), Hôpital Paul Brousse-Assistance Publique - Hôpitaux de Paris, Les Hôpitaux Universitaires de Strasbourg (HUS), University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein (UKSH), Kiel University, IRCCS Istituto Nazionale dei Tumori [Milano], Vall d'Hebron University Hospital [Barcelona], Universitätsklinikum Münster, Universita degli Studi di Padova, CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Azienda Ospedaliera di Padova, Azienda Ospedaliera Ospedale Papa Giovanni XXIII [Bergamo, Italy], Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), UniversitätsKlinikum Heidelberg, Centre Hospitalier Universitaire de Nice (CHU Nice), Leiden University Medical Center (LUMC), Cambridge University Hospitals - NHS (CUH), University of Cambridge [UK] (CAM), Addenbrooke's Hospital, Cambridge University NHS Trust, University Medical Center Groningen [Groningen] (UMCG), University of Groningen [Groningen], Universitätsklinikum Essen [Universität Duisburg-Essen] (Uniklinik Essen), Medizinische Hochschule Hannover (MHH), University of Alberta, Université Catholique de Louvain = Catholic University of Louvain (UCL), Helsinki University Hospital, University Hospitals Birmingham [Birmingham, Royaume-Uni], Queens Elizabeth Hospital [Birmingham], Universitätsklinikum Tübingen - University Hospital of Tübingen, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Policlinico S. Orsola-malpighi, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Servizio sanitario regionale Emilia-Romagna, UZLeuven, Royal Infirmary of Edinburgh, Ludwig-Maximilians-Universität München (LMU), Sahlgrenska University Hospital [Gothenburg], Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, CHU Grenoble, Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Uppsala University Hospital, Universitätsklinikum Jena [Jena], Medizinische Universität Wien = Medical University of Vienna, Royal Prince Alfred Hospital, Karolinska University Hospital [Stockholm], Ghent University Hospital, Hospital Universitario Puerta de Hierro-Majadahonda [Madrid, Spain], University Hospital Regensburg, Fraunhofer Institute for Toxicology and Experimental Medicine (Fraunhofer ITEM), Fraunhofer (Fraunhofer-Gesellschaft), Publica, Schnitzbauer, A. A., Filmann, N., Adam, R., Bachellier, P., Bechstein, W. O., Becker, T., Bhoori, S., Bilbao, I., Brockmann, J., Burra, P., Chazoullieres, O., Cillo, U., Colledan, M., Duvoux, C., Ganten, T. M., Gugenheim, J., Heise, M., van Hoek, B., Jamieson, N., de Jong, K. P., Klein, C. G., Klempnauer, J., Kneteman, N., Lerut, J., Makisalo, H., Mazzaferro, V., Mirza, D. F., Nadalin, S., Neuhaus, P., Pageaux, G. -P., Pinna, A. D., Pirenne, J., Pratschke, J., Powel, J., Rentsch, M., Rizell, M., Rossi, G., Rostaing, L., Roy, A., Scholz, T., Settmacher, U., Soliman, T., Strasser, S., Soderdahl, G., Troisi, R., Turrion, V. S., Schlitt, H. J., Geissler, E. K., Università degli Studi di Padova = University of Padua (Unipd), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Herrada, Anthony, Groningen Institute for Organ Transplantation (GIOT), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)
Subjects: Male, Oncology, [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, medicine.medical_treatment, Medizin, Liver transplantation, MESH: Intention to Treat Analysis, mTOR-inhibition, 0302 clinical medicine, MESH: Liver Neoplasms, Clinical endpoint, MESH: Carcinoma, Hepatocellular, Milan criteria, MESH: Aged, MESH: Middle Aged, Liver Neoplasms, Hazard ratio, Middle Aged, Intention to Treat Analysis, 3. Good health, Survival Rate, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, multivariate COX regression, Female, 030211 gastroenterology & hepatology, MESH: Immunosuppressive Agents, MESH: Neoplasm Recurrence, Local, Immunosuppressive Agents, medicine.drug, medicine.medical_specialty, MESH: Liver Transplantation, Carcinoma, Hepatocellular, MESH: Survival Rate, AFP, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, 03 medical and health sciences, Internal medicine, medicine, Carcinoma, Humans, Survival rate, Aged, Sirolimus, MESH: Humans, business.industry, medicine.disease, digestive system diseases, MESH: Male, Liver Transplantation, Surgery, MESH: Sirolimus, Neoplasm Recurrence, Local, business, MESH: Female
Abstract: OBJECTIVE: The aim of this study was to evaluate the survival benefit of sirolimus in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) (exploratory analysis of the SiLVER-trial). SUMMARY AND BACKGROUND DATA: Patients receiving LT) for HCC are at a high risk for tumor recurrence. Calcineurin inhibitors have shown evidence to promote cancer growth, whereas mammalian target of rapamycin (mTOR) inhibitors like sirolimus have anticancer effects. In the SiLVER-trial (Clinicaltrials.gov: NCT00355862), the effect of sirolimus on the recurrence of HCC after LT was investigated in a prospective randomized trial. Although the primary endpoint of improved disease-free survival (DFS) with sirolimus was not met, outcomes were improved for patients in the sirolimus-treatment arm in the first 3 to 5 years. To learn more about the key variables, a multivariate analysis was performed on the SiLVER-trial data. PATIENTS AND METHODS: Data from 508 patients of the intention-to-treat analysis were included in exploratory univariate and multivariate models for overall survival (OS), DFS and a competing risk analysis for HCC recurrence. RESULTS: Sirolimus use for ≥3 months after LT for HCC independently reduced the hazard for death in the multivariate analysis [hazard ratio (HR): 0.7 (95% confidence interval, CI: 0.52-0.96, P = 0.02). Most strikingly, patients with an alpha-fetoprotein (AFP) ≥10 ng/mL and having used sirolimus for ≥3 months, benefited most with regard to OS, DFS, and HCC-recurrence (HR: 0.49-0.59, P = 0.0079-0.0245). CONCLUSIONS: mTOR-inhibitor treatment with sirolimus for ≥3 months improves outcomes in LT for HCC, especially in patients with AFP-evidence of higher tumor activity, advocating particularly for mTOR inhibitor use in this subgroup of patients. CLINICAL TRIAL REGISTRATION: EudraCT: 2005-005362-36 CLINICALTRIALS.GOV:: NCT00355862. ispartof: ANNALS OF SURGERY vol:272 issue:5 pages:855-862 ispartof: location:United States status: published
Published: 2020

11. Global Quality Standard for Identification and Management of Severe Asthma

Author: Hannah Saul, John Haughney, Precision Improve Access to Better Care Task Force, Steve Holmes, Tonya Winders, Andrew Menzies-Gow, Pascal Chanez, Lucas, Nelly, Queens Elizabeth Hospital [Birmingham], Secretary General of the Global Allergy and Asthma European Network (GA2LEN), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), AstraZeneca, and Royal Brompton Hospital, Lung Division, London, United Kingdom of Great Britain and Northern Ireland.
Subjects: medicine.medical_specialty, Severe asthma, Referral, media_common.quotation_subject, Guideline-directed medical therapy, Disease, macromolecular substances, Patient care, Patient advocacy, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Health care policy, Patient-Centered Care, Health care, medicine, Humans, Pharmacology (medical), Quality (business), 030212 general & internal medicine, Anti-Asthmatic Agents, Precision Medicine, Intensive care medicine, Referral and Consultation, media_common, Asthma, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, General Medicine, medicine.disease, 3. Good health, Identification (information), 030228 respiratory system, Quality care standards, Practice Guidelines as Topic, Commentary, Quality of Life, Risk reduction, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Introduction Severe asthma is a debilitating, life-threatening disease associated with substantial global morbidity, mortality, and health care resource utilization. Patients may not receive guideline-directed medical care for severe asthma. Moreover, viable precision-based assessment tools and newer preventive therapies that can reduce the frequency of exacerbations and associated functional impact are underused. As a result, high rates of poorly controlled severe asthma persist, and patient health-related quality of life suffers. Methods In 2019, the Improve Access to Better Care Task Force of the PRECISION Steering Committee set out to develop a global template on quality standards for severe asthma care to support improved access to and delivery of quality care. This Quality Standard is grounded in the vast body of published evidence available for severe asthma care, published clinical guidelines (i.e., from the Global Initiative for Asthma in 2019 and the European Respiratory Society/American Thoracic Society in 2014), and the 2018 PRECISION-supported Charter to Improve Patient Care in Severe Asthma. Results The Quality Standard developed emphasizes four key elements aimed at optimizing clinical care and outcomes in severe asthma: (1) organization of services, (2) timely identification and referral for suspected severe asthma, (3) specialized assessment and management of severe asthma to optimize outcomes, and (4) patient-centric care and shared decision-making that is reflective of the patient’s expectations, priorities, and values. Four key Quality Statements are provided, along with quality metrics and strategies for local adaptation to optimize implementation. Conclusion This Global Quality Standard is intended to mobilize policymakers, health care providers, and patient advocacy groups to build consensus on the definition and expectations of quality care in severe asthma, to promote patient-centric care, to identify gaps in care and areas for improvement, and systematically implement improvement measures and outcomes and to reduce the burden of illness for patients with severe asthma., Plain Language Summary Although only 10% of patients with asthma have severe disease, these patients use up to half of all health care resources used to treat asthma. For the patient, severe asthma is associated with substantial morbidity, increased risk of death, and poor quality of life. Effective treatments for severe asthma are available, yet access to these treatments varies for many patients around the globe, and they are not always used effectively when available. A task force of leading global asthma experts was recently assembled to develop global standards to support improved access and delivery of quality care for patients with severe asthma. The task force identified four key elements to optimize management and outcomes: (1) coordination of services, (2) timely detection and referral of patients with severe asthma, (3) use of guideline-recommended assessments and therapies, and (4) integration of patient expectations and values when making treatment decisions. This Quality Standard details each of these elements by providing supporting rationale, ways to measure improvements in each area, and strategies to implement these elements at local clinics around the world. Ultimately, this Quality Standard is intended to help policymakers, health care providers, patient advocacy groups, and other key stakeholders build consensus on the requirements for quality care in severe asthma to improve patient care while also reducing the overall global burden of severe asthma.
Published: 2020

12. Post cholecystectomy bile duct injury: early, intermediate or late repair with hepaticojejunostomy – an E-AHPBA multi-center study

Author: Rystedt, J.M.L., Kleeff, J., Salvia, R., Besselink, M.G., Prasad, R., Lesurtel, M., Sturesson, C., Abu Hilal, M., Aljaiuossi, A., Antonucci, A., Ardito, F., Ausania, F., Bernon, M., Berrevoet, F., Bjornsson, B., Bonsing, B.A., Boonstra, E.A., Bracke, B., Brusadin, R., Burda, L., Caraballo, M., Casellas-Robert, M., Coker, A., Davide, J., Gelder, A. de, Rose, A.M. de, Djokic, M., Dudek, K., Ekmekcigil, E., Filauro, M., Fulop, A., Gallagher, T.K., Gastaca, M., Gefen, R., Giuliante, F., Habibeh, H., Halle-Smith, J., Haraldsdottir, K.H., Hartman, V., Hauer, A., Hemmingsson, O., Hoskovec, D., Isaksson, B., Jonas, E., K.A., Klug, R., Krige, J., Lignier, D., Lindemann, J., Lopez-Lopez, V., Lucidi, V., Mabrut, J.Y., Mansson, C., Mieog, S., Mirza, D.F., Oldhafer, K.J., Omoshoro-Jones, J.A.O., Ortega-Torrecilla, N., Otto, W., Panaro, F., Pando, E., Paterna-Lopez, S., Pekmezci, S., Pesce, A., Porte, R.J., Poves, I., Calvo, M.P., Primavesi, F., Puleo, S., Recordare, A., Rizell, M., Roberts, K., Robles-Campos, R., Sanchiz-Cardenas, E., Sandstrom, P., Saribeyoglu, K., Schauer, M., Schreuder, M., Siriwardena, A.K., Smith, M.D., Silva, D.S., Sparrelid, E., Stattner, S., Stavrou, G.A., Straka, M., Stromberg, C., Sutcliffe, R.P., Szijarto, A., Taflin, H., Trotovsek, B., Gulik, T. van, Wallach, N., Zieniewicz, K., European-African HepatoPancreato, Skane University Hospital [Lund], Fachbereich Physik [Halle-Saale], Martin-Luther-Universität Halle Wittenberg (MLU), Azienda Ospedaliera Universitaria Integrata of Verona, University of Amsterdam [Amsterdam] (UvA), St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Karolinska University Hospital [Stockholm], University of Southampton, Policlinico di Monza, Partenaires INRAE, Universita 'La Sapienza' Roma (Istituto CNR), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Catholic University, Rome, Italy, Complexo Hospitalario Universitario de Vigo, Ghent University Hospital, Linköping University (LIU), Universiteit Leiden [Leiden], University Medical Center Groningen [Groningen] (UMCG), Universiteit Antwerpen [Antwerpen], Universidad de Murcia, J. G. Mendel Cancer Center Novy Jicin, Universidad de Salamanca, Hospital Dr Josep Trueta de Girona, Izmir University, TURKEY, Faculdade de Medicina da Universidade do Porto (FMUP), Universidade do Porto, University of Ljubljana, University of Warsaw (UW), İZMİR EGE University Medical Faculty Hospital, Univeristà di Genova, Semmelweis University of Medicine [Budapest], University of Dublin, Universidad de Deusto [Bilbao] (DEUSTO), Universidad de Deusto (DEUSTO), Hospital Universitario Cruces = Cruces University Hospital, Hadassah Hebrew University Hospital, The Hebrew University of Jerusalem (HUJ), Catholic University of Rome, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Queens Elizabeth Hospital [Birmingham], University of Iceland [Reykjavik], Community Hospital of horn, Umeå University, University Hospital Motol [Prague], Uppsala Universitet [Uppsala], University of Cape Town, Hadassah Hebrew University Medical Center [Jerusalem], Community Hospital Horn, CHU Amiens-Picardie, Vrije Universiteit Brussel (VUB), Université de Lyon, Asklepios Klinik Barmbek, University of Johannesburg (UJ), Vall d'Hebron University Hospital [Barcelona], Facultad de Medicina [Zaragoza], University of Zaragoza - Universidad de Zaragoza [Zaragoza], Cerrahpasa Medical Faculty, University of Catania [Italy], IMIM-Hospital del Mar, Generalitat de Catalunya, Innsbruck Medical University [Austria] (IMU), Unité Expérimentale Recherches Intégrées - Gotheron (UERI), Institut National de la Recherche Agronomique (INRA), University of Pristina-Kosovo, Peja/Pec Hospital, Sahlgrenska Academy at University of Gothenburg [Göteborg], Universidad de Málaga [Málaga] = University of Málaga [Málaga], University Hospital Düsseldorf, Vrije Universiteit Medical Centre (VUMC), Vrije Universiteit Amsterdam [Amsterdam] (VU), Manchester Royal Infirmary, University of Manchester [Manchester], Chris Hani Baragwanath Hospital, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), European-African HepatoPancreato, Ege Üniversitesi, Groningen Institute for Organ Transplantation (GIOT), Surgery, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, and AGEM - Endocrinology, metabolism and nutrition
Subjects: INTRAOPERATIVE CHOLANGIOGRAPHY, Male, IMPACT, Settore MED/18 - CHIRURGIA GENERALE, medicine.medical_treatment, Jejunostomy, Hepatic Duct, Common, Comorbidity, 030230 surgery, 0302 clinical medicine, Cholangiography, Older patients, Hepatic Duct, Clinical endpoint, LAPAROSCOPIC CHOLECYSTECTOMY, COMPLICATIONS, OUTCOMES, medicine.diagnostic_test, Bile duct, Gastroenterology, Hepaticojejunostomy, Middle Aged, Common, 3. Good health, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, Adult, medicine.medical_specialty, Bile duct injuries (BDI), CLASSIFICATION, Time-to-Treatment, Biliary injury, 03 medical and health sciences, Sex Factors, HEPATIC-ARTERY INJURY, medicine, MANAGEMENT, Humans, Cholecystectomy, Aged, Retrospective Studies, Hepatology, business.industry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, BILIARY INJURY, Surgery, Multi center study, Concomitant, RISK-FACTORS, Human medicine, Bile Ducts, business
Abstract: 13th World Biennial Congress of the International-Hepato-Pancreato-Biliary-Association (IHPBA) -- SEP 04-07, 2018 -- Geneva, SWITZERLAND, Ardito, Francesco/0000-0003-1596-2862; PESCE, ANTONIO MD/0000-0002-7560-551X; Gallagher, Tom/0000-0002-5765-2574; Bernon, Marc/0000-0002-7967-8548; Stattner, Stefan/0000-0002-5226-7597; GIULIANTE, FELICE/0000-0003-2087-2589; Omoshoro-Jones, Jones A. O./0000-0002-1071-298X; de Rose, Agostino Maria/0000-0003-3310-8088; Abu Hilal, Mohammed/0000-0002-3162-4639; Kleeff, Jorg/0000-0003-3432-6669; Prieto, Mikel/0000-0001-6662-4252; Stromberg, Cecilia/0000-0003-0843-7920, WOS: 000500283700006, PubMed: 31151812, Background: Treatment of bile duct injuries (BDI) during cholecystectomy depends on the severity of injury and the timing of diagnosis. Standard of care for severe BDIs is hepaticojejunostomy. the aim of this retrospective multi-center study was to assess the optimal timing for repair of BDI with hepaticojejunostomy. Methods: Members of the European-African HepatoPancreatoBiliary Association were invited to report all consecutive patients with hepaticojejunostomy after BDI from January 2000 to June 2016. Patients were stratified according to the timing of biliary reconstruction with hepaticojejunostomy: early (day 0-7), intermediate (1-6 weeks) and late (6 weeks-6 months). Primary endpoint was re-intervention >90 days after the hepaticojejunostomy and secondary endpoints were severe 90-day complications and liver-related mortality. Results: in total 913 patients from 48 centers were included in the analysis. in 401 patients (44%) the bile duct injury was diagnosed intraoperatively, and 126 patients (14%) suffered from concomitant vascular injury. in multivariable analysis the timing of hepaticojejunostomy had no impact on postoperative complications, the need for re-intervention after 90 days nor liver-related mortality. the rate of re-intervention more than 90 days after the hepaticojejunostomy was significantly increased in male patients but decreased in older patients. Severe co-morbidity increased the risk for liver-related mortality (HR 3.439; CI 1.37-8.65; p = 0.009). Conclusion: After BDI occurring during cholecystectomy, the timing of biliary reconstruction with hepaticojejunostomy did not have any impact on severe postoperative complications, the need for re-intervention or liver-related mortality. Individualised treatment after iatrogenic bile duct injury is still advisable., Int Hepato Pancreato Biliary Assoc
Published: 2019

13. The PARADIGHM (physicians advancing disease knowledge in hypoparathyroidism) registry for patients with chronic hypoparathyroidism: study protocol and interim baseline patient characteristics

Author: Bart L. Clarke, Claudio Marelli, Maria Luisa Brandi, Michael A. Levine, Sigridur Bjornsdottir, John Germak, Lars Rejnmark, Steven W. Ing, Michael Mannstadt, Dolores M. Shoback, Stefanie Hahner, Lorenz C. Hofbauer, Pinggao Zhang, Neil Gittoes, Tamara Vokes, Aliya Khan, Pascal Houillier, Queens Elizabeth Hospital [Birmingham], Aarhus University Hospital, Ohio State University [Columbus] (OSU), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Karolinska University Hospital [Solna, Sweden] (KUH), University Hospital of Würzburg, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), McMaster University [Hamilton, Ontario], University of Pennsylvania School of Medicine, University of Pennsylvania [Philadelphia], Harvard Medical School [Boston] (HMS), University of California [San Francisco] (UCSF), University of California, The University of Chicago Medicine [Chicago], Takeda company, Takeda Pharmaceuticals International GmbH, and Mayo Clinic [Rochester]
Subjects: Male, Endocrinology, Diabetes and Metabolism, Disease, chemistry.chemical_compound, 0302 clinical medicine, patient registry, Clinical Protocols, Quality of life, Prospective Studies, Registries, Vitamin D, quality of life, rhPTH(1-84), General Medicine, Middle Aged, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Recombinant Proteins, 3. Good health, Treatment Outcome, 030220 oncology & carcinogenesis, Cohort, Female, rhPTH(1-84), Chronic hypoparathyroidism, Adult, medicine.medical_specialty, Hormone Replacement Therapy, Hypoparathyroidism, Renal function, 030209 endocrinology & metabolism, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Physicians, Internal medicine, Diabetes mellitus, medicine, Humans, parathyroid hormone, parathyroid hormone, patient registry, Aged, Creatinine, business.industry, Research, medicine.disease, RC648-665, chemistry, quality of life, Chronic Disease, symptoms, Calcium, Observational study, business
Abstract: Background The PARADIGHM registry of adult and pediatric patients with chronic hypoparathyroidism evaluates the long-term safety and effectiveness of treatment with recombinant human parathyroid hormone, rhPTH(1-84), and describes the clinical disease course under conditions of routine clinical practice. In this first report, we detail the registry protocol and describe the baseline characteristics of two adult patient cohorts from an interim database analysis. One cohort after study entry were prescribed rhPTH(1-84), and the other cohort received conventional therapy of calcium and active vitamin D. Methods An observational study of patients with chronic hypoparathyroidism in North America and Europe, collecting data for ≥10 years per patient. Main outcome measures were baseline patient demographics, clinical characteristics, medications, and disease outcome variables of symptoms, biochemical parameters, and health assessments. Baseline is the enrollment assessment for all variables except biochemical measurements in patients treated with rhPTH(1-84); those measurements were the most recent value before the first rhPTH(1-84) dose. Exclusion criteria applied to the analysis of specified outcomes included pediatric patients, patients who initiated rhPTH(1-84) prior to enrollment, and those who received rhPTH(1-34). Clinically implausible biochemical outlier data were excluded. Results As of 30 June 2019, data of 737 patients were analyzed from 64 centers; 587 (80%) were women, mean ± SD age 49.1±16.45 years. At enrollment, symptoms reported for patients later prescribed rhPTH(1-84) (n=60) and those who received conventional therapy (n=571), respectively, included fatigue (51.7%, 40.1%), paresthesia (51.7%, 29.6%), muscle twitching (48.3%, 21.9%), and muscle cramping (41.7%, 33.8%). Mean serum total calcium, serum phosphate, creatinine, and estimated glomerular filtration rate were similar between cohorts. Health-related quality of life (HRQoL) 36-item Short Form Health Survey questionnaire scores for those later prescribed rhPTH(1-84) were generally lower than those for patients in the conventional therapy cohort. Conclusions At enrollment, based on symptoms and HRQoL, a greater percentage of patients subsequently prescribed rhPTH(1-84) appeared to have an increased burden of disease than those who received conventional therapy despite having normal biochemistry measurements. PARADIGHM will provide valuable real-world insights on the clinical course of hypoparathyroidism in patients treated with rhPTH(1-84) or conventional therapy in routine clinical practice. Trial registration EUPAS16927, NCT01922440
Published: 2019

14. A clinical evaluation of two central venous catheter stabilization systems

Author: Tony Whitehouse, Mercedes Palomar, Jean-François Timsit, Anna L. Casey, Olivier Mimoz, Tarja J. Karpanen, Tom S.J. Elliott, Queens Elizabeth Hospital [Birmingham], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers, Hospital Universitario Arnau de Vilanova de Lleida, Chauzy, Alexia, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord
Subjects: medicine.medical_specialty, Sutureless, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Critical Care and Intensive Care Medicine, 03 medical and health sciences, 0302 clinical medicine, Suture (anatomy), Anesthesiology, medicine, Microbial colonization, 030212 general & internal medicine, Securement, Suture, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, CVC, business.industry, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Outcome measures, 030208 emergency & critical care medicine, lcsh:RC86-88.9, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, equipment and supplies, 3. Good health, Surgery, [SDV] Life Sciences [q-bio], [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, Catheter, Skin irritation, Catheter migration, business, Clinical evaluation, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Central venous catheter
Abstract: Background Central venous catheters (CVCs) are commonly secured with sutures which are associated with microbial colonization and infection. We report a comparison of a suture-free system with standard sutures for securing short-term CVC in an international multicentre, prospective, randomized, non-blinded, observational feasibility study. Consented critical care patients who had a CVC inserted as part of their clinical management were randomized to receive either sutures or the suture-free system to secure their CVC. The main outcome measures were CVC migration (daily measurement of catheter movement) and unplanned catheter removals. Results The per cent of unplanned CVC removal in the two study groups was 2% (suture group 2 out of 86 patients) and 6% (suture-free group 5 out of 85 patients). Both securement methods were well tolerated in terms of skin irritation. The time and ease of application and removal of either securement systems were not rated significantly different. There was also no significant difference in CVC migration between the two securement systems in exploratory univariate and multivariate analyses. Overall, 42% (36 out of 86) of the CVC secured with sutures and 56% (48 out of 85) of the CVC secured with the suture-free securement system had CVC migration of ≥ 2 mm. Conclusions The two securement systems performed similarly in terms of CVC migration and unplanned removal of CVC; however, the feasibility study was not powered to detect statistically significant differences in these two parameters. Trial registration ISRCTN, ISRCTN13939744. Registered 9 July 2015, http://www.isrctn.com/ISRCTN13939744.
Published: 2019

15. Independent clinical appraisal of the Tape Locking Screw (TLS®) anterior cruciate ligament reconstruction technique compared with the hamstring graft technique with a minimum of 12-month follow-up

Author: B. Rubens Duval, Benoît Orfeuvre, Akash Sharma, Julia Gaillot, Dominique Saragaglia, R. Pailhé, Centre Hospitalier Universitaire [Grenoble] (CHU), Gestes Medico-chirurgicaux Assistés par Ordinateur (TIMC-IMAG-GMCAO), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Clinique universitaire de chirurgie orthopédique et de traumatologie du sport, hôpital Sud, CHU de Grenoble, avenue de Kimberley, 38130 Échirolles, France, parent, and Queens Elizabeth Hospital [Birmingham]
Subjects: medicine.medical_specialty, Laxity, Anterior cruciate ligament reconstruction, Anterior cruciate ligament, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 03 medical and health sciences, 0302 clinical medicine, Tape Locking Screw (TLS®), medicine, Orthopedics and Sports Medicine, Prospective cohort study, 030222 orthopedics, business.industry, Significant difference, 030229 sport sciences, Hamstring graft, ST4, Tendon, Surgery, medicine.anatomical_structure, business, Hamstring, Month follow up
Abstract: International audience; INTRODUCTION:The aim of this study was to assess the differential laxity after reconstruction of the anterior cruciate ligament (ACL) by the TLS® technique using a single tendon, the semitendinosus in four-strand graft, compared with the hamstring technique which uses both the gracilis and semitendinosus. We hypothesised that this surgical technique would provide post-surgical differential laxity measurements at least as good as those of the hamstring technique.MATERIALS AND METHODS:We carried out a prospective monocentric study on patients undergoing unilateral anterior cruciate ligament repair between December 2014 and June 2016. All patients were followed up for at least 12 months. The series compares 61 patients operated on using the TLS® technique by the same surgeon, with 33 patients operated on using the hamstring technique by a second surgeon. The main objective of the study was to compare the post-operative differential laxity, measured using the KT1000, between the two techniques.RESULTS:There was no significant difference in the patients' epidemiological characteristics and pre-operative scores between the two groups. Average pre-operative differential laxity was 6.5 mm ± 2.1 (min 3; max 12) in the TLS group and 6.4 mm ± 2.0 (min 0; max 11) in the hamstring group, with no statistically significant difference. The average post-operative difference in laxity was - 0.1 mm ± 1.9 (min - 5; max 4) in the TLS group and 0.3 mm ± 2.0 (min - 7; max 5) in the hamstring group. Again, no significant difference was observed between groups.DISCUSSION:This study demonstrates a level of post-operative differential laxity control using TLS comparable with that of the ACL reconstruction technique using a hamstring graft with preserved tibial insertion
Published: 2019

16. Fast scanning calorimetry clarifies the understanding of the complex melting and crystallization behavior of polyesteramide multi-block copolymers

Author: Sharma, A., Baeza, G.P., Imperiali, L., Appel, W.P.J., Fitié, C., Vanden Poel, G., Ruymbeke, E., Queens Elizabeth Hospital [Birmingham], Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Fast-scanning calorimetries, Melting and crystallization, Calorimetry, Cold crystallization, Polymer crystallization, Block copolymers, Copolymer compositions, Polytetrahydrofuran, [SPI.MAT]Engineering Sciences [physics]/Materials, Calorimeters, Reinforced plastics, Elastomers, Crystallization process, Cooling, Crystallization, Thermoplastic elastomers, Multi blocks, Chemical industry
Abstract: cited By 3; Fast scanning calorimetry has been applied in order to understand the phase transitions in thermoplastic elastomers (TPEs) based on well-defined multi-block copolymers made of ‘soft’ polytetrahydrofuran and ‘hard’ terephthalate ester diamides. The intrinsically complex chemical structure of TPEs leads to complex phase transitions. By changing their thermal history over a wide range of temperature (from −100 °C to 200 °C) and cooling rates (from 10 to 4000 °C s−1), we clarify the origins of the various phases present in these materials. In particular, we study the different possibilities for the hard segments to associate depending on their mobility during the quenching phase, forming either strong and stable structures or weaker and metastable ones. Besides, we demonstrate that a minimal cooling rate of 800 °C s−1 is necessary to keep these TPEs (made of short and monodisperse hard segments) amorphous leading to a subsequent cold crystallization when heating back, at around 30 °C. Finally, we validate our interpretations by varying the copolymer composition (from 10 wt% to 20 wt% hard segments), revealing the thermal invariance of poorly organized domains. Based on these data, we also discuss the importance of chain diffusion in the crystallization process. Applying fast scanning calorimetry allows us to link fundamental understanding to industrial application. © 2018 Society of Chemical Industry. © 2018 Society of Chemical Industry
Published: 2019

17. Brentuximab vedotin for recurrent Hodgkin lymphoma after allogeneic hematopoietic stem cell transplantation: A report from the EBMT Lymphoma Working Party

Author: Bazarbachi, Ali, Boumendil, Ariane, Finel, Hervé, Mohty, Mohamad, Castagna, Luca, Blaise, Didier, Peggs, Karl, Afanasyev, Boris, Diez-Martin, J.L., Corradini, Paolo, Michonneau, David, Robinson, Stephen, Gutiérrez García, Gonzalo, Bonifazi, Francesca, Yakoub-Agha, Ibrahim, Gülbas, Zafer, Bloor, Adrian, Delage, Jeremy, Esquirol, Albert, Malladi, Ram, Scheid, Christof, El-Cheikh, Jean, Ghesquieres, Hervé, Montoto, Silvia, Dreger, Peter, Sureda, Anna, American University of Beirut [Beyrouth] (AUB), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'hématologie clinique et de thérapie cellulaire [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Sorbonne Université (SU), Istituto Clinico Humanitas [Milan] (IRCCS Milan), Humanitas University [Milan] (Hunimed), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), University College London Hospitals (UCLH), Hospital General Universitario 'Gregorio Marañón' [Madrid], Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University Hospitals Bristol, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Lille Inflammation Research International Center - U 995 (LIRIC), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Lapeyronie [Montpellier] (CHU), Queens Elizabeth Hospital [Birmingham], University Hospital of Cologne [Cologne], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Heidelberg University Hospital [Heidelberg], Institut Pasteur de Lille, and Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
Subjects: Adult, Male, Salvage Therapy, Immunoconjugates, recurrence, Hematopoietic Stem Cell Transplantation, donor lymphocyte infusion, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, Middle Aged, Hodgkin Disease, Survival Analysis, Young Adult, Treatment Outcome, allogeneic stem cell transplantation (allo-SCT), brentuximab vedotin, Humans, Female, Neoplasm Recurrence, Local, Hodgkin lymphoma, Aged, Retrospective Studies
Abstract: Background The treatment of patients with Hodgkin lymphoma (HL) who develop disease progression after undergoing allogeneic stem cell transplantation (allo-SCT) remains challenging. Methods The authors assessed outcomes in 184 adult patients with HL who developed disease recurrence or progression after a matched related or unrelated allo-SCT at European Society for Blood and Marrow Transplantation-participating centers between 2010 and 2014. Results Eighty patients who received brentuximab vedotin (BV) salvage therapy were compared with 104 patients who did not. Patients in the BV group were younger (median age of 30 years vs 34 years) and were more likely to receive pretransplant BV (65% vs 46%) or posttransplant donor lymphocyte infusion (66% vs 33%). The 2 groups otherwise were comparable. Patients in the BV group received a median of 6 doses of posttransplant BV, resulting in a complete remission rate of 29%, a partial response rate of 45%, and a stable disease rate of 26%. Response to BV after allo-SCT did not appear to be affected by receipt of pretransplant BV. Despite a longer median follow-up for surviving patients in the BV group (33 months vs 23 months; P
Published: 2019

18. Prognostic value of end-of-induction PET response after first-line immunochemotherapy for follicular lymphoma (GALLIUM): secondary analysis of a randomised, phase 3 trial

Author: Judith Trotman, Sally F Barrington, David Belada, Michel Meignan, Robert MacEwan, Carolyn Owen, Václav Ptáčník, András Rosta, Günter R Fingerle-Rowson, Jiawen Zhu, Tina Nielsen, Deniz Sahin, Wolfgang Hiddemann, Robert E Marcus, Andrew Davies, Mark Hertzberg, Andrew Grigg, Paul Cannell, Hang Quach, Stephen Opat, Constantine Tam, Paula Marlton, Ann Janssens, Fritz Offner, Koen Van eygen, Randeep Sangha, Pam Mckay, Jonathan Wilson, Richard Van Der Jagt, Daryl Roitman, Marek Trneny, Jiri Mayer, Katell Le Du, Philippe Solal-Celigny, Guillaume Cartron, Charles Foussard, Norbert Frickhofen, Peter Schmidt, Ullrich Graeven, Tobias Gaska, Rudolf Schlag, Martin Sökler, Gabriele Prange-Krex, Axel Florschütz, Hans-Walter Lindemann, Christoph Schimmelpfennig, Solveig Tonndorf, Mathias Hänel, Georg Hess, Enrico Schalk, Heiko Hütten, Gottfried Doelken, Michael Pfreundschuh, Ulrich Keller, Michael Herold, Roswitha Forstpointner, Ursula Vehling-Kaiser, Martin Hoffmann, Zita Borbenyi, Miklos Udvardy, Judit Demeter, Alessandro Rambaldi, Enrica Morra, Federico Massimo, Ignazio Majolino, Monica Balzarotti, Gianpietro Semenzato, Miguel Angel Canales Albendea, Francisco Javier Peñalver Parraga, Alfonso Soler Campos, Juan Manuel Sancho Cia, Jose Antonio Marquez Navarro, Carlos Grande Garcia, Herman Nilsson-Ehle, Helen Mccarthy, Chris Pocock, Shalal Sadullah, Ram Malladi, John Radford, Ed Kanfer, Anton Kruger, Dominic Culligan, Martin Dyer, Ruth Pettengell, John Seymour, John Gribben, Saad Al-Ismail, Faris Al-Refaie, Norbert Blesing, Christopher Macnamara, Ann O'callaghan, Andrew Haynes, George Follows, Roderick Johnson, David Cunningham, Kristian Bowles, Graham Collins, Eve Gallop-Evans, Stephen Robinson, Chezhian Subash, James Bailey, Viran Holden, Jeffrey Neidhart, Moacyr De Oliveira, Haluk Tezcan, Kevin Kim, Suman Kambhampati, Keith Lanier, John Mcclean, Kensei Tobinai, Kiyohiko Hatake, Michinori Ogura, Toshiki Uchida, Kiyoshi Ando, Tomohiro Kinoshita, Thomas Höhler, Heribert Stauder, Andreas Kirsch, Michael Koenigsmann, Stephan Kremers, Thomas Illmer, Mathias Witzens-Harig, Paul La Roseé, Jan Dürig, Michael Kneba, Manfred Hensel, Stefan Fuxius, Lothar Bergmann, Kai Hübel, Christian Buske, Reinhard Marks, Gerald Wulf, Christian Lerchenmueller, Rudolf Schmits, Mark Reinwald, Eva Lengfelder, Fiona Scott, Takaaki Chou, Masafumi Taniwaki, Isao Yoshida, Kenichi Ishizawa, Naokuni Uike, Nobuhiko Uoshima, Yuri Kamitsuji, Shinsuke Iida, Ken Ohmine, Kisato Nosaka, Kazuhiko Ide, Takayuki Ishikawa, Pierre Desjardins, Nicholas Finn, Jun Zhu, Wei Li, Li Yu, Hanyun Ren, Yuan Kai Shi, Gang Wu, Xiaonan Hong, Qingyuan Zhang, Jifeng Feng, Rong Zhan, Tongyu Lin, Sirpa Leppa, Regis Costello, Adrian Tempescul, Laurence Sanhes, Olivier Tournilhac, Heinz Kirchen, Holger Hebart, Rudolf Weide, Kathleen Jentsch-Ullrich, Irit Avivi, Arnon Nagler, Ronit Gurion, Ofer Shpilberg, Pietro Leoni, Luca Baldini, Olga Samoylova, Alexandr Myasnikov, Tran-Der Tan, Hung Chang, Kyoya Kumagai, Norifumi Tsukamoto, Kunihiro Tsukasaki, Patrick Beatty, Noriko Usui, Koji Izutsu, Tohru Murayama, Tatsuo Ichinohe, Kohmei Kubo, Fumihiro Ishida, J. Thaddeus Beck, Frank Griesinger, Dzhelil Osmanov, Shaker Dakhil, Aline Clavert, Dai Maruyama, Yasuhito Terui, Kazuhito Yamamoto, Ekkehard Eigendorff, Tsutomu Kobayashi, Satoshi Ichikawa, Ilseung Choi, Katsuya Wada, Yoshitaka Kikukawa, Masao Matsuoka, Takayuki Yoshino, Yosuke Minami, Dürig, Jan (Beitragende*r), The University of Sydney, Service de médecine nucléaire [Créteil], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Prince of Wales Medical Research Institute, University of New South Wales [Sydney] (UNSW), University of Melbourne, Universiteit Gent = Ghent University [Belgium] (UGENT), Service d'hématologie et oncologie médicale, Hôpital Lapeyronie-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Semmelweis University of Medicine [Budapest], Queens Elizabeth Hospital [Birmingham], Queen Mary University of London (QMUL), IBM Thomas J. Watson Research Center, IBM, Department of Computing and Information Systems, and Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie-Université de Montpellier (UM)
Subjects: Male, Time Factors, [SDV]Life Sciences [q-bio], Follicular lymphoma, Medizin, chemistry.chemical_compound, 0302 clinical medicine, Antineoplastic Agents, Immunological, Obinutuzumab, Antineoplastic Combined Chemotherapy Protocols, Clinical endpoint, Prospective Studies, Lymphoma, Follicular, Randomized Controlled Trials as Topic, education.field_of_study, Manchester Cancer Research Centre, Hazard ratio, Middle Aged, Progression-Free Survival, 3. Good health, Oncology, 030220 oncology & carcinogenesis, Female, Immunotherapy, Rituximab, medicine.drug, Bendamustine, medicine.medical_specialty, Population, Antibodies, Monoclonal, Humanized, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, medicine, Humans, Progression-free survival, education, Aged, Neoplasm Staging, Retrospective Studies, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, medicine.disease, chemistry, Clinical Trials, Phase III as Topic, Positron-Emission Tomography, business, Tomography, X-Ray Computed, Progressive disease, 030215 immunology
Abstract: BACKGROUND: Initial results from the ongoing GALLIUM trial have shown that patients with follicular lymphoma have a longer progression-free survival after first-line immunochemotherapy with obinutuzumab than with rituximab. The aim of this secondary analysis was to evaluate the prognostic value of PET-CT responses after first-line immunochemotherapy in the GALLIUM study.METHODS: GALLIUM is an open-label, parallel-group randomised, phase 3 trial, which recruited previously untreated patients with CD20-positive follicular lymphoma (grades 1-3a; disease stage III/IV, or stage II with largest tumour diameter ≥7 cm) who were aged 18 years or older and met the criteria for needing treatment. Eligible patients were randomly assigned in a 1:1 ratio to receive intravenous administration of obinutuzumab (1000 mg on days 1, 8, and 15 of cycle 1, then day 1 of subsequent cycles) or rituximab (375 mg/m2 on day 1 of each cycle), in six 21-day cycles with cyclophosphamide, doxorubicin, vincristine, and prednisone (known as CHOP; oral administration) followed by two 21-day cycles of antibody alone, or eight 21-day cycles cyclophosphamide, vincristine, and prednisone (known as CVP; oral administration), or six 28-day cycles with bendamustine, followed by maintenance antibody every 2 months for up to 2 years. The primary endpoint of the trial, investigator-assessed progression-free survival, has been reported previously. This secondary analysis reports PET and CT-based responses at end-of-induction therapy and explains their relation with progression-free and overall survival outcomes in patients with available scans. As per protocol, during the trial, PET scans (mandatory in the first 170 patients enrolled at sites with available PET facilities, and optional thereafter), acquired at baseline and end of induction (PET population), were assessed prospectively by investigators and an independent review committee (IRC) applying International Harmonisation Project (IHP) 2007 response criteria, and retrospectively by the IRC only applying current Lugano 2014 response criteria. IRC members (but not study investigators) were masked to treatment and clinical outcome when assessing response. The landmark analyses excluded patients who died or progressed (contrast enhanced CT-based assessment of progressive disease, or started next anti-lymphoma treatment) before or at end of induction. GALLIUM is registered at ClinicalTrials.gov, number NCT01332968.FINDINGS: 1202 patients were enrolled in GALLIUM between July 6, 2011, and Feb 4, 2014, of whom 595 were included in the PET population; 533 (IHP 2007; prospective analysis), and 508 (Lugano 2014; retrospective analysis) were analysed for progression-free survival (landmark analysis). At end of induction, 390 of 595 patients (65·5% [95% CI 61·6-69·4]) achieved PET complete response according to IHP 2007 criteria, and 450 (75·6% [95% CI 72·0-79·0]) obtained PET complete metabolic response according to Lugano 2014 criteria. With a median of 43·3 months of observation (IQR 36·2-51·8), 2·5-year progression-free survival from end of induction was 87·8% (95% CI 83·9-90·8) in PET complete responders and 72·0% (63·1-79·0) in non-complete responders according to IRC-assessed IHP 2007 criteria (hazard ratio [HR] 0·4, 95% CI 0·3-0·6, pINTERPRETATION: Our results suggest that PET is a better imaging modality than contrast-enhanced CT for response assessment after first-line immunochemotherapy in patients with follicular lymphoma. PET assessment according to Lugano 2014 response criteria provides a platform for investigation of response-adapted therapeutic approaches. Additional supportive data are welcomed.FUNDING: F Hoffmann-La Roche.
Published: 2018

19. Gaia Data Release 2. Summary of the contents and survey properties

Author: Collaboration, G., Brown, A., Vallenari, A., Prusti, T., de Bruijne, J., Babusiaux, C., Bailer-Jones, C., Biermann, M., Evans, D., Eyer, L., Jansen, F., Jordi, C., Klioner, S., Lammers, U., Lindegren, L., Luri, X., Mignard, F., Panem, C., Pourbaix, D., Randich, S., Sartoretti, P., Siddiqui, H., Soubiran, C., van Leeuwen, F., Walton, N., Arenou, F., Bastian, U., Cropper, M., Drimmel, R., Katz, D., Lattanzi, M., Bakker, J., Cacciari, C., Castañeda, J., Chaoul, L., Cheek, N., De Angeli, F., Fabricius, C., Guerra, R., Holl, B., Masana, E., Messineo, R., Mowlavi, N., Nienartowicz, K., Panuzzo, P., Portell, J., Riello, M., Seabroke, G., Tanga, P., Thévenin, F., Gracia-Abril, G., Comoretto, G., Garcia-Reinaldos, M., Teyssier, D., Altmann, M., Andrae, R., Audard, M., Bellas-Velidis, I., Benson, K., Berthier, J., Blomme, R., Burgess, P., Busso, G., Carry, B., Cellino, A., Clementini, G., Clotet, M., Creevey, O., Davidson, M., De Ridder, J., Delchambre, L., Dell'Oro, A., Ducourant, C., Fernández-Hernández, J., Fouesneau, M., Frémat, Y., Galluccio, L., García-Torres, M., González-Núñez, J., González-Vidal, J., Gosset, E., Guy, L., Halbwachs, J., Hambly, N., Harrison, D., Hernández, J., Hestroffer, D., Hodgkin, S., Hutton, A., Jasniewicz, G., Jean-Antoine-Piccolo, A., Jordan, S., Korn, A., Krone-Martins, A., Lanzafame, A., Lebzelter, T., Löffler, W., Manteiga, M., Marrese, P., Martín-Fleitas, J., Moitinho, A., Mora, A., Muinonen, K., Osinde, J., Pancino, E., Pauwels, T., Petit, J., Recio-Blanco, A., Richards, P., Rimoldini, L., Robin, A., Sarro, L., Siopis, C., Smith, M., Sozzetti, A., Süveges, M., Torra, J., van Reeven, W., Abbas, U., Abreu Aramburu, A., Accart, S., Aerts, C., Altavilla, G., Álvarez, M., Alvarez, R., Alves, J., Anderson, R., Andrei, A., Anglada Varela, E., Antiche, E., Antoja, T., Arcay, B., Astraatmadja, T., Bach, N., Baker, S., Balaguer-Núñez, L., Balm, P., Barache, C., Barata, C., Barbato, D., Barblan, F., Barklem, P., Barrado, D., Barros, M., Barstow, M., Bartholomé Muñoz, S., Bassilana, J., Becciani, U., Bellazzini, M., Berihuete, A., Bertone, S., Bianchi, L., Bienaymé, O., Blanco-Cuaresma, S., Boch, T., Boeche, C., Bombrun, A., Borrachero, R., Bossini, D., Bouquillon, S., Bourda, G., Bragaglia, A., Bramante, L., Breddels, M., Bressan, A., Brouillet, N., Brüsemeister, T., Brugaletta, E., Bucciarelli, B., Burlacu, A., Busonero, D., Butkevich, A., Buzzi, R., Caffau, E., Cancelliere, R., Cannizzaro, G., Cantat-Gaudin, T., Carballo, R., Carlucci, T., Carrasco, J., Casamiquela, L., Castellani, M., Castro-Ginard, A., Charlot, P., Chemin, L., Chiavassa, A., Cocozza, G., Costigan, G., Cowell, S., Crifo, F., Crosta, M., Crowley, C., Cuypers, J., Dafonte, C., Damerdji, Y., Dapergolas, A., David, P., David, M., de Laverny, P., De Luise, F., De March, R., de Martino, D., de Souza, R., de Torres, A., Debosscher, J., del Pozo, E., Delbo, M., Delgado, A., Delgado, H., Di Matteo, P., Diakite, S., Diener, C., Distefano, E., Dolding, C., Drazinos, P., Durán, J., Edvardsson, B., Enke, H., Eriksson, K., Esquej, P., Eynard Bontemps, G., Fabre, C., Fabrizio, M., Faigler, S., Falcão, A., Farràs Casas, M., Federici, L., Fedorets, G., Fernique, P., Figueras, F., Filippi, F., Findeisen, K., Fonti, A., Fraile, E., Fraser, M., Frézouls, B., Gai, M., Galleti, S., Garabato, D., García-Sedano, F., Garofalo, A., Garralda, N., Gavel, A., Gavras, P., Gerssen, J., Geyer, R., Giacobbe, P., Gilmore, G., Girona, S., Giuffrida, G., Glass, F., Gomes, M., Granvik, M., Gueguen, A., Guerrier, A., Guiraud, J., Gutiérrez-Sánchez, R., Haigron, R., Hatzidimitriou, D., Hauser, M., Haywood, M., Heiter, U., Helmi, A., Heu, J., Hilger, T., Hobbs, D., Hofmann, W., Holland, G., Huckle, H., Hypki, A., Icardi, V., Janßen, K., Jevardat de Fombelle, G., Jonker, P., Juhász, Á., Julbe, F., Karampelas, A., Kewley, A., Klar, J., Kochoska, A., Kohley, R., Kolenberg, K., Kontizas, M., Kontizas, E., Koposov, S., Kordopatis, G., Kostrzewa-Rutkowska, Z., Koubsky, P., Lambert, S., Lanza, A., Lasne, Y., Lavigne, J., Le Fustec, Y., Le Poncin-Lafitte, C., Lebreton, Y., Leccia, S., Leclerc, N., Lecoeur-Taibi, I., Lenhardt, H., Leroux, F., Liao, S., Licata, E., Lindstrøm, H., Lister, T., Livanou, E., Lobel, A., López, M., Managau, S., Mann, R., Mantelet, G., Marchal, O., Marchant, J., Marconi, M., Marinoni, S., Marschalkó, G., Marshall, D., Martino, M., Marton, G., Mary, N., Massari, D., Matijevič, G., Mazeh, T., McMillan, P., Messina, S., Michalik, D., Millar, N., Molina, D., Molinaro, R., Molnár, L., Montegriffo, P., Mor, R., Morbidelli, R., Morel, T., Morris, D., Mulone, A., Muraveva, T., Musella, I., Nelemans, G., Nicastro, L., Noval, L., O'Mullane, W., Ordénovic, C., Ordóñez-Blanco, D., Osborne, P., Pagani, C., Pagano, I., Pailler, F., Palacin, H., Palaversa, L., Panahi, A., Pawlak, M., Piersimoni, A., Pineau, F., Plachy, E., Plum, G., Poggio, E., Poujoulet, E., Prša, A., Pulone, L., Racero, E., Ragaini, S., Rambaux, N., Ramos-Lerate, M., Regibo, S., Reylé, C., Riclet, F., Ripepi, V., Riva, A., Rivard, A., Rixon, G., Roegiers, T., Roelens, M., Romero-Gómez, M., Rowell, N., Royer, F., Ruiz-Dern, L., Sadowski, G., Sagristà Sellés, T., Sahlmann, J., Salgado, J., Salguero, E., Sanna, N., Santana-Ros, T., Sarasso, M., Savietto, H., Schultheis, M., Sciacca, E., Segol, M., Segovia, J., Ségransan, D., Shih, I., Siltala, L., Silva, A., Smart, R., Smith, K., Solano, E., Solitro, F., Sordo, R., Soria Nieto, S., Souchay, J., Spagna, A., Spoto, F., Stampa, U., Steele, I., Steidelmüller, H., Stephenson, C., Stoev, H., Suess, F., Surdej, J., Szabados, L., Szegedi-Elek, E., Tapiador, D., Taris, F., Tauran, G., Taylor, M., Teixeira, R., Terrett, D., Teyssandier, P., Thuillot, W., Titarenko, A., Torra Clotet, F., Turon, C., Ulla, A., Utrilla, E., Uzzi, S., Vaillant, M., Valentini, G., Valette, V., van Elteren, A., Van Hemelryck, E., van Leeuwen, M., Vaschetto, M., Vecchiato, A., Veljanoski, J., Viala, Y., Vicente, D., Vogt, S., von 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Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Observatoire Astronomique de l'Université de Genève (ObsGE), Université Grenoble Alpes - UFR Langage, lettres et arts du spectacle, information et communication - Dpt Lettres et arts du spectacle (UGA UFR LLASIC LAS), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), INAF - Osservatorio Astronomico di Padova (OAPD), FORMATION STELLAIRE 2018, CICEnergigune, Atotech Deutschland GmbH, Atotech, Centre d'étude spatiale des rayonnements (CESR), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astronomico di Roma (OAR), Queen Elizabeth Hospital, Queens Elizabeth Hospital [Birmingham], Institute of Astronomy [Leuven], Hospital Israelita Albert Einstein [São Paulo, Brazil], Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Department of Computing, Electronics and Mechatronics, Universidad de las Américas [Puebla] (UDLAP), Uppsala University, Laboratoire de Spectroscopie Hertzienne de l'ENS (LSH-ENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), Service de médecine interne diabète et maladies métaboliqe, Hôpital civil Strasbourg, Observatoire astronomique de Strasbourg (OAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Aberystwyth University, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre National d'Études Spatiales [Toulouse] (CNES), Sciences Pour l'Oenologie (SPO), Université Montpellier 1 (UM1)-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Department of Physics [Athens], National and Kapodistrian University of Athens (NKUA), Departament Llenguatges i Sistemes Informatics, Universitat Politècnica de Catalunya [Barcelona] (UPC), DEE, Budapest University of Technology and Economics [Budapest] (BME), European Space Astronomy Centre (ESAC), Laboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux (L3AB), Laboratoire national de métrologie et d'essais - Systèmes de Référence Temps-Espace (LNE - SYRTE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ingienerie des Polymères pour les Hautes Technologies (LIPHT), Ecole européenne de chimie, polymères et matériaux [Strasbourg]-Centre National de la Recherche Scientifique (CNRS), Chinese Academy of Sciences [Beijing] (CAS), Leibniz-Institut für Astrophysik Potsdam (AIP), Atmel Corporation (ATMEL), ATMEL, Astrophysics Research Institute [Liverpool] (ARI), Liverpool John Moores University (LJMU), Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, TKK Helsinki University of Technology (TKK), Laboratoire de Recherche sur la Réactivité des Solides (LRRS), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), School of Physics and Astronomy [Tel Aviv] (TAU), Raymond and Beverly Sackler Faculty of Exact Sciences [Tel Aviv] (TAU), Tel Aviv University (TAU)-Tel Aviv University (TAU), Centre for Integrative Physiology, University of Edinburgh, Istituto Nazionale di Astrofisica (Istituto Nazionale di Astrofisica), Istituto Nazionale di Fisica Nucleare (INFN), Diagnostic Imaging and Research Institute, University of Toronto, Centre Atlantique de Philosophie (CAPHI), PRES Université Nantes Angers Le Mans (UNAM), Service de Neurologie [Hôpitaux Civils de Colmar], Hôpitaux Civils Colmar, Laboratoire d'astrophysique de l'observatoire de Besançon (UMR 6091) (LAOB), INAF - Osservatorio Astronomico di Capodimonte (OAC), Institut de recherche de l'European Business School (IREBS), European Business School Paris (EBS Paris), Département Réseaux, Information, Multimédia (RIM-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre G2I, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Department of Biochemical and Chemical Engineering, Technische Universität Dortmund [Dortmund] (TU), Centre de recherche en linguistique et traitement automatique des langues, Lucien Tesnière - UFC (EA 2283) (TESNIERE), Université de Franche-Comté (UFC), Astronomical Observatory [Poznan], Adam Mickiewicz University in Poznań (UAM), Université Paris 1 Panthéon-Sorbonne - UFR d'Économie (UP1 UFR02), Université Paris 1 Panthéon-Sorbonne (UP1), Spanish Virtual Observatory - Observatorio Virtual Español (SVO), Spanish Virtual Observatory - Observatorio Virtual Español, Geophysical Laboratory [Carnegie Institution], Carnegie Institution for Science, Institut d'Astrophysique et de Géophysique [Liège], Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Instituto de Astronomia, Geofísica e Ciências Atmosféricas [São Paulo] (IAG), Universidade de São Paulo = University of São Paulo (USP), Center for health studies, Dipartimento di Fisica, Politecnico di Milano [Milan] (POLIMI), Ecologie, Evolution, Symbiose (EES), Ecologie et biologie des interactions (EBI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Astrometry, Istituto Nazionale di Astrofisica (INAF)-Istituto Nazionale di Astrofisica (INAF), Karl-Franzens-Universität Graz, Herpetological Section, Zoologisches Forschungsmuseum Alexander Koenig, Institute of Hydrology, Department of Astrophysics [Nijmegen], Institute for Mathematics, Astrophysics and Particle Physics (IMAPP), Radboud University [Nijmegen]-Radboud University [Nijmegen], Laboratoire de l'Accélérateur Linéaire (LAL), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Lohrmann Observatory, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Ben-Gurion University of the Negev (BGU), Kapteyn Astronomical Institute, Astronomy, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL), Royal Observatory of Belgium [Brussels], Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées, Solvay Silica, Solvay (France), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, École normale supérieure - Paris (ENS Paris), Agence Spatiale Européenne (ESA), European Space Agency (ESA), University of Geneva [Switzerland], Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg], Nelson Mandela Metropolitan University [Port Elizabeth, South Africa], Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université de Genève (UNIGE), Association pour le Développement de l'Apiculture Provençale (ADAPI), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), University of Helsinki, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), AUTRES, Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Hospital Israelita Albert Einstein, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Recherche Agronomique (INRA), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), School of Physics and Astronomy [Tel Aviv], Tel Aviv University [Tel Aviv], Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Carnegie Institution for Science [Washington], Universidade de São Paulo (USP), Radboud university [Nijmegen]-Radboud university [Nijmegen], Universidad de Cantabria, Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Pomies, Marie-Paule, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Recherche Agronomique (INRA), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Sciences et Technologies - Bordeaux 1, ITA, USA, GBR, FRA, DEU, ESP, PSL Research University (PSL)-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Libre de Bruxelles [Bruxelles] (ULB), PSL Research University (PSL)-PSL Research University (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Università di Bologna [Bologna] (UNIBO), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Groupe de Recherche en Astronomie et Astrophysique du Languedoc (GRAAL), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Osservatorio Astronomico di Bologna (OABO), AGROCAMPUS OUEST-Institut National de la Recherche Agronomique (INRA), National Institute for Subatomic Physics Nikhef [Amsterdam] (NIKHEF), Spanish National Research Council (CSIC), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), observatoire astronomique de strasbourg, Université Grenoble Alpes (UGA), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' [Rome], Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD [Nouvelle-Calédonie])-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), National and Kapodistrian University of Athens = University of Athens (NKUA | UoA), PSL Research University (PSL)-PSL Research University (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, National Institute for Nuclear Physics (INFN), Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'astrophysique de l'observatoire de Besançon (LAOB), Université Panthéon-Sorbonne - UFR d'Économie (UP1 UFR02), Université Panthéon-Sorbonne (UP1), Instituto de Astronomia, Geofisica e Ciencias Atmosfericas [Sao Paulo] (IAG), Technische Universität Dresden (TUD), and Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: SKY SURVEY 2MASS, Astronomy, catalogs, astrometry, techniques: radial velocities, stars: fundamental parameters, stars: variables: general, minor planets, asteroids: general, Astrophysics, minor planets, asteroids: general, 01 natural sciences, Catàlegs d'estels, variables: general [Stars], Star catalogs, techniques: radial velocities, 010303 astronomy & astrophysics, Physics, Astrometry, CATALOG, Asteroids, asteroids: general, Radial velocity, stars: variables: general, Physical Sciences, astrometry, stars: fundamental parameters, Astrophysics - Instrumentation and Methods for Astrophysics, general [minor planets, asteroids], Asteroides, Proper motion, Vista Variables in the Via Lactea, Astrometria, DATABASE, FOS: Physical sciences, Photometric system, Astronomy & Astrophysics, fundamental parameters [Stars], Photometry (optics), [SDU.ASTR.IM] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Apparent magnitude, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, catalogs, minor planets, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysique, Science & Technology, radial velocities [Techniques], 010308 nuclear & particles physics, Minor planets, Astronomy and Astrophysics, Astronomie, Astrophysics - Astrophysics of Galaxies, Stars, Galaxy, EVOLUÇÃO ESTELAR, Estels, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], 13. Climate action, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Gaia Data Release 2. Summary of the contents and survey properties, Catalogs, SKY, general [Asteroids], STARS
Abstract: Context. We present the second Gaia data release, Gaia DR2, consisting of astrometry, photometry, radial velocities, and information on astrophysical parameters and variability, for sources brighter than magnitude 21. In addition epoch astrometry and photometry are provided for a modest sample of minor planets in the solar system. Aims. A summary of the contents of Gaia DR2 is presented, accompanied by a discussion on the differences with respect to Gaia DR1 and an overview of the main limitations which are still present in the survey. Recommendations are made on the responsible use of Gaia DR2 results. Methods. The raw data collected with the Gaia instruments during the first 22 months of the mission have been processed by the Gaia Data Processing and Analysis Consortium (DPAC) and turned into this second data release, which represents a major advance with respect to Gaia DR1 in terms of completeness, performance, and richness of the data products. Results. Gaia DR2 contains celestial positions and the apparent brightness in G for approximately 1.7 billion sources. For 1.3 billion of those sources, parallaxes and proper motions are in addition available. The sample of sources for which variability information is provided is expanded to 0.5 million stars. This data release contains four new elements: broad-band colour information in the form of the apparent brightness in the GBP (330-680 nm) and GRP (630-1050 nm) bands is available for 1.4 billion sources; median radial velocities for some 7 million sources are presented; for between 77 and 161 million sources estimates are provided of the stellar effective temperature, extinction, reddening, and radius and luminosity; and for a pre-selected list of 14 000 minor planets in the solar system epoch astrometry and photometry are presented. Finally, Gaia DR2 also represents a new materialisation of the celestial reference frame in the optical, the Gaia-CRF2, which is the first optical reference frame based solely on extragalactic sources. There are notable changes in the photometric system and the catalogue source list with respect to Gaia DR1, and we stress the need to consider the two data releases as independent. Conclusions. Gaia DR2 represents a major achievement for the Gaia mission, delivering on the long standing promise to provide parallaxes and proper motions for over 1 billion stars, and representing a first step in the availability of complementary radial velocity and source astrophysical information for a sample of stars in the Gaia survey which covers a very substantial fraction of the volume of our galaxy., 0, info:eu-repo/semantics/published
Published: 2018

20. Molecular prevalence of bovine noroviruses and neboviruses in newborn calves in Iran

Author: Pourasgari , Farzaneh, Kaplon , Jérôme, Sanchooli , Alireza, Fremy , Céline, Karimi-Naghlani , Shahla, Otarod , Vahid, Ambert-Balay , Katia, Mojgani , Naheed, Pothier , Pierre, Toronto General Hospital Research Institute [Canada] ( TGHRI ), Department of Biotechnology [Karaj - Iran], Razi Vaccine and Serum Research Institute [Iran] ( RVSRI ), Procédés Alimentaires et Microbiologiques [Dijon] ( PAM ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté ( UBFC ), Centre National de Référence des virus entériques [CHU de Dijon] ( CNR virus entériques ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Queens Elizabeth Hospital [Birmingham], Laboratoire de sérologie-virologie (CHU de Dijon), and Iranian Veterinary Organization [Iran] ( IVO )
Subjects: fluids and secretions, [ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Abstract: International audience; In this study, bovine enteric caliciviruses (BECs) were detected in 49.4% of a total of 253 stool specimens for diarrheic calves collected from 42 industrial dairy farms from March 2010 to February 2012. Genogroup III norovirus (NoVsGIII) were more prevalent (39.5%) than neboviruses (NBs) (15%), and coinfections were observed in 5.1% of the samples tested. Sequence analysis of the partial polymerase gene from 13 NoVsGIII samples indicated the circulation of both genotype 1 and genotype 2 strains. Among the six NB strains sequenced, five were related to the Bo/Nebraska/80/US strain, while one was related to the Bo/Newbury1/76/UK strain
Published: 2018

21. A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill

Author: Olivier Mimoz, Thiago Lisboa, Vineet Chopra, Jean-Jacques Parienti, Jean-François Timsit, Emilio Bouza, Kevin B. Laupland, Walter Zingg, Tarja J. Karpanen, Garyphalia Poulakou, Mark E. Rupp, Leonard A. Mermel, Bertrand Souweine, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), University of Nebraska Medical Center, University of Nebraska System, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Hospital General Universitario 'Gregorio Marañón' [Madrid], University of Michigan [Ann Arbor], University of Michigan System, Queens Elizabeth Hospital [Birmingham], Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospital de Clínicas de Porto Alegre (HCPA), Warren Alpert Medical School of Brown University, Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers, Unité de Biostatistique et de Recherche Clinique (UBRC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Université d'Athènes (UOA), Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS)-Université d'Auvergne - Clermont-Ferrand I (UdA), Hôpitaux Universitaires de Genève (HUG), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinical Microbiology and Infectious Diseases Department, Universidad Complutense de Madrid [Madrid] (UCM), Service d'anesthésie réanimation [Poitiers], Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Adult, Male, medicine.medical_specialty, Catheterization, Central Venous, Critical Illness, Intravascular catheter, Critical Care and Intensive Care Medicine, Critical Care Nursing, 03 medical and health sciences, 0302 clinical medicine, Catheters, Indwelling, Multidisciplinary approach, Risk Factors, Anesthesiology, Sepsis, Catheterization, Peripheral, Medicine, Central Venous Catheters, Humans, 030212 general & internal medicine, Intensive care medicine, Pulmonary emboli, Critically ill, ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, ddc:616, business.industry, 030208 emergency & critical care medicine, Thrombosis, State of the art review, Process of care, Middle Aged, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 3. Good health, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Practice Guidelines as Topic, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, business
Abstract: Intravascular catheters are inserted into almost all critically ill patients. This review provides up-to-date insight into available knowledge on epidemiology and diagnosis of complications of central vein and arterial catheters in ICU. It discusses the optimal therapy of catheter-related infections and thrombosis. Prevention of complications is a multidisciplinary task that combines both improvement of the process of care and introduction of new technologies. We emphasize the main component of the prevention strategies that should be used in critical care and propose areas of future investigation in this field.
Published: 2018

22. Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding

Author: Emilse Bermejo, Michele P. Lambert, Chris Van Geet, Samya Obaji, Marie-Christine Alessi, Sofia Papadia, Matthias Canault, Shoshana Revel-Vilk, Daniel Greene, Andrew D Mumford, Ernest Turro, Salih Tuna, Sarah K Westbury, Kate Downes, Willem H. Ouwehand, Carolyn M. Millar, Christopher Watt, Kathleen Freson, Katharine Hanlon, Paquita Nurden, Michael Laffan, Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biostatistics Unit, Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA)-UNICANCER-Université Côte d'Azur (UCA), Hematological Research Institute, National Academy of Medicine, Department of Haematology [Glasgow Royal Infirmary], University of Glasgow-Glasgow Royal Infirmary, Institut Parisien de Recherche Architecture Urbanistique Société (IPRAUS), Architecture Urbanisme Société : Savoir Enseignement Recherche (UMR AUSser), Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture et de la Communication (MCC)-École nationale supérieure d'architecture de Paris-Belleville (ENSA PB)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-École nationale supérieure d'architecture de Paris-Malaquais (ENSAPM)-École Nationale Supérieure d'Architecture de la Ville et des Territoires à Marne-la-Vallée (éavt&t)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture et de la Communication (MCC)-École nationale supérieure d'architecture de Paris-Belleville (ENSA PB)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-École nationale supérieure d'architecture de Paris-Malaquais (ENSAPM)-École Nationale Supérieure d'Architecture de la Ville et des Territoires à Marne-la-Vallée (éavt&t), IHU-LIRYC, CHU Bordeaux [Bordeaux]-Université Bordeaux Segalen - Bordeaux 2, Pediatric Hematology/Oncology Department, Hadassah Hebrew University Medical Center [Jerusalem], Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Université Catholique de Louvain = Catholic University of Louvain (UCL), NIHR BioResource - Rare Diseases, Cambridge University Hospitals (CUH), Department of Haematology, Queens Elizabeth Hospital [Birmingham], NHS Blood and Transplant, Center for Molecular and Vascular Biology, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), University of Cambridge [UK] (CAM), The Wellcome Trust Sanger Institute [Cambridge], Nutrition, obésité et risque thrombotique ( NORT ), Institut National de la Recherche Agronomique ( INRA ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), CRLCC Antoine Lacassagne, Institut Parisien de Recherche Architecture Urbanistique Société ( IPRAUS ), Architecture Urbanisme Société : Savoir Enseignement Recherche ( UMR AUSser ), École nationale supérieure d'architecture de Paris-La Villette ( ENSAPLV ) -École nationale supérieure d'architecture de Paris-Belleville ( ENSA PB ) -Ministère de la Culture et de la Communication ( MCC ) -École nationale supérieure d'architecture de Paris-Malaquais ( ENSAPM ) -Centre National de la Recherche Scientifique ( CNRS ) -École nationale supérieure d'architecture de Paris-La Villette ( ENSAPLV ) -École nationale supérieure d'architecture de Paris-Belleville ( ENSA PB ) -Ministère de la Culture et de la Communication ( MCC ) -École nationale supérieure d'architecture de Paris-Malaquais ( ENSAPM ) -Centre National de la Recherche Scientifique ( CNRS ), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Université Catholique de Louvain, Cambridge University Hospitals ( CUH ), Queen Elizabeth Hospital, Catholic University of Leuven ( KU Leuven ), University of Cambridge [UK] ( CAM ), Medical Research Council (MRC), Downes, Kate [0000-0003-0366-1579], Papadia, Sofia [0000-0002-9222-3812], Tuna, Salih [0000-0003-3606-4367], Ouwehand, Willem [0000-0002-7744-1790], Turro Bassols, Ernest [0000-0002-1820-6563], Apollo - University of Cambridge Repository, École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-École nationale supérieure d'architecture de Paris-Belleville (ENSA PB)-Ministère de la Culture et de la Communication (MCC)-École nationale supérieure d'architecture de Paris-Malaquais (ENSAPM)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Architecture de la Ville et des Territoires à Marne-la-Vallée (éavt&t)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-École nationale supérieure d'architecture de Paris-Belleville (ENSA PB)-Ministère de la Culture et de la Communication (MCC)-École nationale supérieure d'architecture de Paris-Malaquais (ENSAPM)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Architecture de la Ville et des Territoires à Marne-la-Vallée (éavt&t)
Subjects: Male, 0301 basic medicine, genetic disorde, 030204 cardiovascular system & hematology, Bioinformatics, Biochemistry, ACTIVATION, 0302 clinical medicine, ISTH, GENETIC-VARIANTS, [SDV.IDA]Life Sciences [q-bio]/Food engineering, 1114 Paediatrics And Reproductive Medicine, Guanine Nucleotide Exchange Factors, Missense mutation, Platelet, WORLDWIDE SURVEY, [ SDV.GEN.GH ] Life Sciences [q-bio]/Genetics/Human genetics, ComputingMilieux_MISCELLANEOUS, Blood Platelet Disorders, Hematology, [ SDV.IDA ] Life Sciences [q-bio]/Food engineering, DEFECTS, Phenotype, trouble génétiq, Pedigree, 3. Good health, phénotype, thrombocytopath, Female, Life Sciences & Biomedicine, Blood Platelets, medicine.medical_specialty, DISORDERS, NIHR BioResource–Rare Diseases Consortium, Platelet disorder, Immunology, Hemorrhage, DIAGNOSIS, 1102 Cardiovascular Medicine And Haematology, 03 medical and health sciences, Internal medicine, Journal Article, medicine, Humans, Alleles, Science & Technology, Base Sequence, MUTATIONS, business.industry, Genetic heterogeneity, THROMBOCYTOPENIA, séquençage à ha, 1103 Clinical Sciences, Cell Biology, activation plaq, 030104 developmental biology, Platelet transfusion, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Mutation, CALDAG-GEFI, business
Abstract: International audience; Heritable platelet function disorders (PFDs) are genetically heterogeneous and poorly characterised. Pathogenic variants in RASGRP2, which encodes calcium and diacylglycerol-regulated guanine exchange factor I (CalDAG-GEFI), have been reported previously in three pedigrees with bleeding and reduced platelet aggregation responses. To better define the phenotype associated with pathogenic RASGRP2 variants, we compared high-throughput sequencing and phenotype data from 2,042 cases in pedigrees with unexplained bleeding or platelet disorders to data from 5,422 controls. Eleven cases harboured 11 different, previously unreported RASGRP2 variants that were biallelic and likely pathogenic. The variants included five high-impact variants predicted to prevent CalDAG-GEFI expression and six missense variants affecting the CalDAG-GEFI CDC25 domain, which mediates Rap1 activation during platelet inside-out αIIbβ3 signalling. Cases with biallelic RASGRP2 variants had abnormal mucocutaneous, surgical and dental bleeding from childhood, requiring at least one blood or platelet transfusion in 78% of cases. Platelets displayed reduced aggregation in response to ADP and epinephrine, but variable aggregation defects with other agonists. There were no other consistent clinical or laboratory features. These data enable definition of human CalDAG-GEFI deficiency as a non-syndromic, recessive PFD associated with a moderate or severe bleeding phenotype and complex defects in platelet aggregation.
Published: 2017

23. The Global Alliance for Infections in Surgery : defining a model for antimicrobial stewardship-results from an international cross-sectional survey

Author: Federico Coccolini, Leonel Lagunes, André Ricardo Araujo da Silva, Massimo Sartelli, Sara Al-Dahir, Young R. Lee, Mario Tumbarello, Faryal Khamis, Natalia Santos, Jean Carlet, Fausto Catena, Agron Dogjani, Jan Ulrych, Isidro Martinez Casas, András Vereczkei, Salomone Di Saverio, Sydney Malama, Harry van Goor, Garima Kapoor, Hong Bin Kim, Norio Sato, Gustavo M. Machain, Chinmay Gandhi, Iryna Kozlovska, Ramiro Manzano-Nunez, Katia Iskandar, Fikri M. Abu-Zidan, Sujith J Chandy, Rosio Isabel Guerra Gronerth, Therese M. Duane, Lena M. Napolitano, Carlos A. Ordoñez, Yonghong Xiao, Michael McFarlane, Cristian Mesina, Sanjay Marwah, Goran Augustin, Tatjana Goranovic, Bruno M. Pereira, Ivan Kerschaever, Timothy Craig Hardcastle, Marcelo A. Beltrán, Stephen Y. Liang, Julio C. Haidamus Monteiro, Vishalkumar G Shelat, Kuo Ching Yuan, Sandro Scarpelini, Narayan Dutt Pant, Martha Quiodettis, Carlos Alves, Mutasim M. Elmangory, Céline Pulcini, Addison K. May, Guntars Pupelis, Selman Uranues, Pamela Barbadoro, Sandro Rizoli, Ernest E. Moore, Rifat Latifi, Ashish Khanna, Hossein Samadi Kafil, Richard R. Watkins, Boonying Siribumrungwong, Abdelkarim H. Omari, Agnes Wechsler-Fördös, Lewis J. Kaplan, Nusrat Shafiq, Jason A. Roberts, Warren Lowman, Laurent Dortet, Stephen M. Brecher, Luca Ansaloni, Rodolfo Soto, Tanya L. Zakrison, Sameer Dhingra, Jacobus Preller, Eleftherios Mylonakis, Wagih Ghnnam, Asri Che Jusoh, Pierluigi Viale, Costi D. Sifri, Miklosh Bala, José Gustavo Parreira, Alfredo Ponce-de-León, Jae G. Lee, Jakub Kenig, Kjetil Søreide, Halil Alis, Lilian M. Abbo, Mahir Gachabayov, Marco Catani, Ronald Kiguba, Jean-Ralph Zahar, Wietse P. Zuidema, Robert G. Sawyer, Loredana Scoccia, Nuno Pereira, Vladimir Khokha, Ionut Negoi, Aneel Bhangu, Michał Pędziwiatr, Helen Giamarellou, Garyphallia Poulakou, Shyam Kumar Mishra, Francesco Di Marzo, Jeffrey M. Tessier, Boris Sakakushev, Milica D. Nestorovic, Hamilton Petry de Souza, Tarcisio Reis, Yousheng Li, Dominik Mertz, Andreas Hecker, Ngo Tat Trung, Anand Kumar, Belefquih Bouchra, Leonardo Pagani, James M. Sanders, AA Munyika, Brian S. Zuckerbraun, Souha S. Kanj, Arda Isik, Luigia Scudeller, Adrien Hodonou, Philip S. Barie, Marc Maegele, Jill R. Cherry-Bukowiec, Peep Talving, Orestis Ioannidis, Miran Rems, Oliver A. Cornely, Harumi Gomi, Ewen A. Griffiths, Mushira Enani, Zaza Demetrashvili, Gereltuya Dorj, Piotr Major, Miguel Caínzos, Ari Leppäniemi, Jesús Rodríguez-Baño, Wen Chien Ko, Ziad A. Memish, Osvaldo Chiara, Elif Colak, José Artur Paiva, A R K Adesunkanmi, Timothy M. Rawson, Georgios Gkiokas, Paula Ferrada, Francesco M. Labricciosa, Alain Chichom-Mefire, Jan J. De Waele, Yunfeng Cui, Adrián Camacho-Ortiz, J. Esteban Foianini, Majdi N. Al-Hasan, Belinda De Simone, David P. Nicolau, Kaoru Koike, Athanasios Marinis, Florian M.E. Wagenlehner, Aleksandar Karamarkovic, Adrian Brink, Emilio Maseda, II kirurgian klinikka, Department of Surgery, Clinicum, HUS Abdominal Center, Surgery, Other Research, Università degli Studi di Macerata = University of Macerata (UNIMC), Università Politecnica delle Marche [Ancona] (UNIVPM), Central Hospital [Bolzano, Italy], Hospital Papa Giovanni XXIII (Hosp P Giovanni XXIII), Milpark Hospital (Milpark Hospital), Milpark Hospital, University of Cape Town, World Alliance against Antibiotics Resistance, Cleveland Clinic, Regional Hospital, Limbe, Rimini Infermi Hospital, Maggiore Hospital, Vanderbilt University Medical Center [Nashville], Vanderbilt University [Nashville], University of Bologna, Northeastern Ohio Medical University (NEOMED), Foundation IRCCS Policlinico San Matteo, University of Miami Leonard M. Miller School of Medicine (UMMSM), United Arab Emirates University (UAEU), Obafemi Awolowo University (OAU), Xavier University of Louisiana, University of South Carolina School of Medicine, Columbia, South Carolina, Training Hospital Istanbul, Hospital de São João [Porto], Centro de Investigação em Estudos da Criança (CIEC), Universidade do Minho, University Hospital Center Zagreb, Hadassah Hebrew University Medical Center [Jerusalem], Weill Cornell Medicine [New York], Universidad de La Serena (USERENA), Queens Elizabeth Hospital [Birmingham], Université Internationale de Casablanca (UIC), VA Boston Healthcare System, Boston University School of Medicine (BUSM), Boston University [Boston] (BU), Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of psychiatry-King‘s College London, University Hospital of Cologne [Cologne], 4th Department of Internal Medicine, University of Athens Medical School [Athens], Center for Visual Information Technology [Hyderabad] (CVIT), International Institute of Information Technology, Hyderabad [Hyderabad] (IIIT-H), Chonnam National University [Gwangju], Shanghai Jiaotong University, University of Houston, Centro Hospitalar Universitário São João - Faculty of Medicine - University of Porto - Grupo de Infecção e Sepsis, Porto, Unité de biostatistiques, CHU Clermont-Ferrand, ATTIKON University General Hospital, Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Duke University Marine Laboratory, University Hospital Virgen Macarena, Service de bactériologie, virologie, parasitologie et hygiène, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sartelli, M, Labricciosa, FM, Barbadoro, P, Pagani, L, Dorj, G, Catena, Fausto, Sartelli, Massimo, Labricciosa, Francesco M., Barbadoro, Pamela, Pagani, Leonardo, Ansaloni, Luca, Brink, Adrian J., Carlet, Jean, Khanna, Ashish, Chichom-Mefire, Alain, Coccolini, Federico, Di Saverio, Salomone, May, Addison K., Viale, Pierluigi, Watkins, Richard R., Scudeller, Luigia, Abbo, Lilian M., Abu-Zidan, Fikri M., Adesunkanmi, Abdulrashid K., Al-Dahir, Sara, Al-Hasan, Majdi N., Alis, Halil, Alves, Carlo, Araujo da Silva, André R., Augustin, Goran, Bala, Miklosh, Barie, Philip S., Beltrán, Marcelo A., Bhangu, Aneel, Bouchra, Belefquih, Brecher, Stephen M., Caínzos, Miguel A., Camacho-Ortiz, Adrian, Catani, Marco, Chandy, Sujith J., Jusoh, Asri Che, Cherry-Bukowiec, Jill R., Chiara, Osvaldo, Colak, Elif, Cornely, Oliver A., Cui, Yunfeng, Demetrashvili, Zaza, De Simone, Belinda, De Waele, Jan J., Dhingra, Sameer, Di Marzo, Francesco, Dogjani, Agron, Dorj, Gereltuya, Dortet, Laurent, Duane, Therese M., Elmangory, Mutasim M., Enani, Mushira A., Ferrada, Paula, Esteban Foianini, J., Gachabayov, Mahir, Gandhi, Chinmay, Ghnnam, Wagih Mommtaz, Giamarellou, Helen, Gkiokas, Georgio, Gomi, Harumi, Goranovic, Tatjana, Griffiths, Ewen A., Guerra Gronerth, Rosio I., Haidamus Monteiro, Julio C., Hardcastle, Timothy C., Hecker, Andrea, Hodonou, Adrien M., Ioannidis, Oresti, Isik, Arda, Iskandar, Katia A., Kafil, Hossein S., Kanj, Souha S., Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar R., Kenig, Jakub, Kerschaever, Ivan, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Hong B., Ko, Wen-Chien, Koike, Kaoru, Kozlovska, Iryna, Kumar, Anand, Lagunes, Leonel, Latifi, Rifat, Lee, Jae G., Lee, Young R., Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Lowman, Warren, Machain, Gustavo M., Maegele, Marc, Major, Piotr, Malama, Sydney, Manzano-Nunez, Ramiro, Marinis, Athanasio, Martinez Casas, Isidro, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael E., Memish, Ziad, Mertz, Dominik, Mesina, Cristian, Mishra, Shyam K., Moore, Ernest E., Munyika, Akutu, Mylonakis, Eleftherio, Napolitano, Lena, Negoi, Ionut, Nestorovic, Milica D., Nicolau, David P., Omari, Abdelkarim H., Ordonez, Carlos A., Paiva, José-Artur, Pant, Narayan D., Parreira, Jose G., Pedziwiatr, Michal, Pereira, Bruno M., Ponce-de-Leon, Alfredo, Poulakou, Garyphallia, Preller, Jacobu, Pulcini, Céline, Pupelis, Guntar, Quiodettis, Martha, Rawson, Timothy M., Reis, Tarcisio, Rems, Miran, Rizoli, Sandro, Roberts, Jason, Pereira, Nuno Rocha, Rodríguez-Baño, Jesú, Sakakushev, Bori, Sanders, Jame, Santos, Natalia, Sato, Norio, Sawyer, Robert G., Scarpelini, Sandro, Scoccia, Loredana, Shafiq, Nusrat, Shelat, Vishalkumar, Sifri, Costi D., Siribumrungwong, Boonying, Søreide, Kjetil, Soto, Rodolfo, de Souza, Hamilton P., Talving, Peep, Trung, Ngo Tat, Tessier, Jeffrey M., Tumbarello, Mario, Ulrych, Jan, Uranues, Selman, Van Goor, Harry, Vereczkei, Andra, Wagenlehner, Florian, Xiao, Yonghong, Yuan, Kuo-Ching, Wechsler-Fördös, Agne, Zahar, Jean-Ralph, Zakrison, Tanya L., Zuckerbraun, Brian, and Zuidema, Wietse P.
Subjects: 0301 basic medicine, Cross-sectional study, Psychological intervention, Antibiotics, Antimicrobial stewardship, Infections, Surgery, Anti-Infective Agents, Antimicrobial Stewardship, Cross-Sectional Studies, Global Health, Humans, Intraabdominal Infections, Postoperative Complications, Surveys and Questionnaires, GUIDELINES, HEALTH-CARE EPIDEMIOLOGY, 0302 clinical medicine, Global health, Medicine and Health Sciences, PROGRAM, Infection control, Medicine, 030212 general & internal medicine, Response rate (survey), DISEASES SOCIETY, lcsh:Medical emergencies. Critical care. Intensive care. First aid, 3. Good health, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], CIRURGIA, Emergency Medicine, Infection, Life Sciences & Biomedicine, medicine.medical_specialty, 030106 microbiology, lcsh:Surgery, MEDLINE, 03 medical and health sciences, Antibiotic resistance, AMERICA, Science & Technology, business.industry, Antibiotic, lcsh:RD1-811, lcsh:RC86-88.9, 3126 Surgery, anesthesiology, intensive care, radiology, HOSPITALS, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: Contains fulltext : 177987.pdf (Publisher’s version ) (Open Access) BACKGROUND: Antimicrobial Stewardship Programs (ASPs) have been promoted to optimize antimicrobial usage and patient outcomes, and to reduce the emergence of antimicrobial-resistant organisms. However, the best strategies for an ASP are not definitively established and are likely to vary based on local culture, policy, and routine clinical practice, and probably limited resources in middle-income countries. The aim of this study is to evaluate structures and resources of antimicrobial stewardship teams (ASTs) in surgical departments from different regions of the world. METHODS: A cross-sectional web-based survey was conducted in 2016 on 173 physicians who participated in the AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections) project and on 658 international experts in the fields of ASPs, infection control, and infections in surgery. RESULTS: The response rate was 19.4%. One hundred fifty-six (98.7%) participants stated their hospital had a multidisciplinary AST. The median number of physicians working inside the team was five [interquartile range 4-6]. An infectious disease specialist, a microbiologist and an infection control specialist were, respectively, present in 80.1, 76.3, and 67.9% of the ASTs. A surgeon was a component in 59.0% of cases and was significantly more likely to be present in university hospitals (89.5%, p < 0.05) compared to community teaching (83.3%) and community hospitals (66.7%). Protocols for pre-operative prophylaxis and for antimicrobial treatment of surgical infections were respectively implemented in 96.2 and 82.3% of the hospitals. The majority of the surgical departments implemented both persuasive and restrictive interventions (72.8%). The most common types of interventions in surgical departments were dissemination of educational materials (62.5%), expert approval (61.0%), audit and feedback (55.1%), educational outreach (53.7%), and compulsory order forms (51.5%). CONCLUSION: The survey showed a heterogeneous organization of ASPs worldwide, demonstrating the necessity of a multidisciplinary and collaborative approach in the battle against antimicrobial resistance in surgical infections, and the importance of educational efforts towards this goal.
Published: 2017

24. Best practices for the management of local-regional recurrent chordoma: a position paper by the chordoma global consensus group

Author: Vittoria Colia, Bernd Kasper, R. Imai, Michael Baumann, Stéphanie Bolle, R. Capanna, Riccardo Casadei, Paolo G. Casali, Claire Alapetite, P. A. Gardner, C. L. A. Vleggeert-Lankamp, C. Heery, Elena Tamborini, Anant Desai, Stefano Radaelli, Alessandro Gronchi, Nadia Hindi, Akira Kawai, Daniel Vanel, C. Sen, Francesco Doglietto, Nicolas Penel, Ziya L. Gokaslan, S. Froelich, Katherine Anne Thornton, Carlo Morosi, Hans Gelderblom, Francis J. Hornicek, O. J. Norum, M. Uhl, Palma Dileo, Sandip Pravin Patel, Piero Fossati, J. Martin Broto, Peter Hohenberger, Rick L. Haas, Andreas Leithner, Toru Akiyama, F. Ricchini, Robin L. Jones, Valter Torri, Josh Sommer, Peter Pal Varga, Y. Yamada, Per-Ulf Tunn, J.-Y. Blay, Augusto Caraceni, Piotr Rutkowski, Jürgen Debus, Lee Jeys, Adrienne M. Flanagan, Diego Mazzatenta, I. Logowska, Marco Krengli, Damien C. Weber, Thomas F. DeLaney, Susanne Scheipl, P. Picci, Beate Timmermann, Piero Nicolai, S. Pilotti, P. Bruzzi, Silvia Stacchiotti, Stefano Boriani, S. Dijkstra, Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan], European Institute of Oncology [Milan] (ESMO), Saitama University, Institut Curie [Paris], University of Dresden Medical School, Centre Léon Bérard [Lyon], Institut Gustave Roussy (IGR), University of Pisa - Università di Pisa, University Medical Center Heidelberg, Massachusetts General Hospital [Boston], Queen Elizabeth Hospital, University College London Hospitals (UCLH), Universiteit Leiden [Leiden], University of Brescia, Cancer Research UK London Research Institute, Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE), Providence University, Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Hospital Universitario Virgen del Rocío [Sevilla], University of Heidelberg, Medical Faculty, Harvard Medical School [Boston] (HMS), Chiba University Hospital, Queens Elizabeth Hospital [Birmingham], Royal Marsden NHS Foundation Trust, National Cancer Center Research Institute [Tokyo], Università del Piemonte Orientale - Dipartimento DISIT Italy, Medical University Graz, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (MCMCC), MD Anderson Cancer Center [Houston], The University of Texas Health Science Center at Houston (UTHealth), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University Hospital Graz, New York University Langone Medical Center (NYU Langone Medical Center), NYU System (NYU), University of Duisbourg-Essen, Helios Klinikum [Erfurt], Memorial Sloane Kettering Cancer Center [New York], SwissFEL, Paul Scherrer Institut, Leiden University Medical Center (LUMC), Universiteit Leiden, CHU Lille, Université de Lille, METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, European Institute of Oncology [Milan] [ESMO], Institut Gustave Roussy [IGR], University College London Hospitals [UCLH], Netherlands Cancer Institute [NKI], National Cancer Institute [Bethesda] [NCI-NIH], Harvard Medical School [Boston] [HMS], Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology [MCMCC], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], New York University Langone Medical Center [NYU Langone Medical Center], Leiden University Medical Center [LUMC], Stacchiotti, S., Gronchi, A., Fossati, P., Akiyama, T., Alapetite, C., Baumann, M., Blay, J. Y., Bolle, S., Boriani, S., Bruzzi, P., Capanna, R., Caraceni, A., Casadei, R., Colia, V., Debus, J., Delaney, T., Desai, A., Dileo, P., Dijkstra, S., Doglietto, F., Flanagan, A., Froelich, S., Gardner, P. A., Gelderblom, H., Gokaslan, Z. L., Haas, R., Heery, C., Hindi, N., Hohenberger, P., Hornicek, F., Imai, R., Jeys, L., Jones, R. L., Kasper, B., Kawai, A., Krengli, M., Leithner, A., Logowska, I., Martin Broto, J., Mazzatenta, D., Morosi, C., Nicolai, P., Norum, O. J., Patel, S., Penel, N., Picci, P., Pilotti, S., Radaelli, S., Ricchini, F., Rutkowski, P., Scheipl, S., Sen, C., Tamborini, E., Thornton, K. A., B., Timmermann, Torri, V., Tunn, P. U., Uhl, M., Yamada, Y., Weber, D. C., Vanel, D., Varga, P. P., Vleggeert-Lankamp, C. L. A., Casali, P. G., and Sommer, J.
Subjects: sarcoma, [SDV]Life Sciences [q-bio], Medizin, chemotherapy, Patient advocacy, surgery, 0302 clinical medicine, Neoplasm Recurrence, Medicine, chordoma, relapse, radiotherapy, Relapse, Sarcoma, Hematology, 3. Good health, Oncology, 030220 oncology & carcinogenesis, Practice Guidelines as Topic, chordoma, consensus, recurrence, Sacral Chordoma, musculoskeletal diseases, medicine.medical_specialty, recurrence, Best practice, MEDLINE, Reviews, 610 Medicine & health, 03 medical and health sciences, Chordoma, Humans, Chemotherapy, Medical physics, Radiotherapy, business.industry, medicine.disease, Cervical spine, consensus, Family medicine, Position paper, Surgery, Neoplasm Recurrence, Local, business, 030217 neurology & neurosurgery
Abstract: Chordomas are rare, malignant bone tumors of the skull-base and axial skeleton. Until recently, there was no consensus among experts regarding appropriate clinical management of chordoma, resulting in inconsistent care and suboptimal outcomes for many patients. To address this shortcoming, the European Society of Medical Oncology (ESMO) and the Chordoma Foundation, the global chordoma patient advocacy group, convened a multi-disciplinary group of chordoma specialists to define by consensus evidence-based best practices for the optimal approach to chordoma. In January 2015, the first recommendations of this group were published, covering the management of primary and metastatic chordomas. Additional evidence and further discussion were needed to develop recommendations about the management of local-regional failures. Thus, ESMO and CF convened a second consensus group meeting in November 2015 to address the treatment of locally relapsed chordoma. This meeting involved over 60 specialists from Europe, the United States and Japan with expertise in treatment of patients with chordoma. The consensus achieved during that meeting is the subject of the present publication and complements the recommendations of the first position paper.
Published: 2017

25. IL-4/CXCL12 loop is a key regulator of lymphoid stroma function in follicular lymphoma

Author: Mark Coles, Anja Mottok, Patricia Amé-Thomas, Joelle Dulong, Thierry Fest, Céline Pangault, Tony Marchand, Céline Monvoisin, Fabien Guilloton, Shubham Pandey, Saba Nayar, Frédéric Mourcin, Francesca Barone, Marion Guirriec, Karin Tarte, Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Queens Elizabeth Hospital [Birmingham], University of York [York, UK], University of British Columbia (UBC), Ligue Nationale Contre le Cancer (Equipe Labellisée and 'Carte d'identité des Tumeurs' program), Institut National du cancer (INCA AAP PLBIO-14-40), Immunofluorescence study was performed on the Microscopy Rennes Imaging Center (MRic-ALMF, UMS 6480 Biosit, Rennes, France)., Centre de Ressources Biologiques (CRB)-Santé (BB-0033-00056,http://www.crbsante-rennes.com) of Rennes hospital, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Jonchère, Laurent
Subjects: [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Stromal cell, Immunology, Follicular lymphoma, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, T-Lymphocytes, Regulatory, Biochemistry, Mice, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Bone Marrow, Cell Movement, medicine, Animals, Humans, Lymphoma, Follicular, PI3K/AKT/mTOR pathway, Interleukin 4, Mice, Knockout, B-Lymphocytes, Germinal center, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Cell Biology, Hematology, medicine.disease, Chemokine CXCL12, Lymphoma, 030104 developmental biology, medicine.anatomical_structure, Lymphatic system, Cancer research, Female, Interleukin-4, Lymph Nodes, Bone marrow, Stromal Cells, Signal Transduction
Abstract: International audience; Follicular lymphoma (FL) is the most frequent indolent lymphoma and is characterized by the accumulation of germinal center-derived malignant B cells engaged in a bidirectional crosstalk with their supportive microenvironment in invaded lymph nodes (LNs) and bone marrow (BM). T follicular helper (TFH) cells and infiltrating stromal cells have been shown to favor FL B-cell growth, but the mechanisms of their protumoral effect and how the LN/BM microenvironment is converted into a lymphoma-permissive cell niche remain poorly understood. We demonstrated here that FL-infiltrating LN and BM stromal cells overexpressed CXCL12 in situ. Interleukin-4 high (IL-4hi) FL-TFH cells, unlike FL B cells themselves, triggered CXCL12 upregulation in human stromal cell precursors. In agreement, expression of CXCL12 was associated with IL-4 expression and signaling within the FL BM and LN niches. This IL-4/CXCL12 axis was amplified in activated lymphoid stromal cells as shown in our in vitro model of human lymphoid stroma differentiation and in an inducible mouse model of ectopic lymphoid organ formation. Finally, CXCL12 triggered primary FL B-cell activation, migration, and adhesion, a process antagonized by BTK and PI3K inhibitors. These data identified the IL-4/CXCL12 loop as a previously unrecognized pathway involved in lymphoid stroma polarization and as a potential therapeutic target in FL patients.
Published: 2017

26. The molecular epidemiology of bovine rotaviruses circulating in Iran: a two-year study

Author: Pourasgari , Farzaneh, Kaplon , Jérôme, Karimi-Naghlani , Shahla, Fremy , Céline, Otarod , Vahid, Ambert-Balay , Katia, Mirjalili , Ali, Pothier , Pierre, Toronto General Hospital Research Institute [Canada] ( TGHRI ), Department of Biotechnology [Karaj - Iran], Razi Vaccine and Serum Research Institute [Iran] ( RVSRI ), Procédés Alimentaires et Microbiologiques ( PAM ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Laboratoire de sérologie-virologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Queens Elizabeth Hospital [Birmingham], Iranian Veterinary Organization [Iran] ( IVO ), Organize and Promote Epidemiological Network ( Open Rome ), and Razi Vaccine and Serum Research Institute, Iran [2-18-18-88050]
Subjects: Identification, PCR, Serotypes, Group-a rotavirus, Diarrheic calves, Polymerase-chain-reaction, [ SDV.IDA ] Life Sciences [q-bio]/Food engineering, Strains, Dairy herds, Egyptian children, P VP4 genotypes
Abstract: International audience; Bovine group A rotavirus (bovine RVA) is recognized as a major cause of severe gastroenteritis in newborn calves. The purpose of this study was to estimate the prevalence and identify the genotypes of circulating bovine RVA in newborn diarrheic calves. Two hundred fifty-three stool samples of diarrheic calves up to 1 month old were collected from 42 industrial dairy farms in two Iranian provinces during March 2010 to February 2012. All collected samples were screened for the presence of bovine RVA by RT-PCR, and the G and P genotypes were determined by semi-nested multiplex RT-PCR assay. The results of RT-PCR indicated that 49.4 % (125 out of 253) of the samples were positive for bovine RVA. The G and P genotyping of a subset of positive samples (n = 85) by semi-nested multiplex RT-PCR revealed that G6 (55.3 %) and G10 (43.5 %) and P[5] (51.8 %) and P[11] (27 %) were the most prevalent G and P genotypes, respectively. G6P[5] was the dominant genotype (35.3 %), followed by G10P[5], G10P[11] and G6P[11], with prevalence rates of 16.5 %, 15.3 % and 10.6 %, respectively. Sequence analysis of 20 VP7 and four VP4 genes showed highest nucleotide sequence identity with the corresponding genes of strains RVA/Cow-tc/GBR/UK/1973/G6P7[5] and RVA/Cow-tc/USA/B223/XXXX/G10P[11]. The results of this study reveal the diversity of G and P genotypes in bovine RVA samples from diarrheic Iranian calves and expands our knowledge of bovine RVA infections in the Middle East. These results also highlight the importance of producing of an effective rotavirus vaccine and its inclusion in the national cattle immunization program.
Published: 2016

27. Comparative study of computer-assisted total knee arthroplasty after opening wedge osteotomy versus after unicompartmental arthroplasty

Author: Régis Pailhé, Dominique Saragaglia, Akash Sharma, Rouchy Rc, Brice Rubens-Duval, Massfelder J, Cognault J, Gestes Medico-chirurgicaux Assistés par Ordinateur (TIMC-IMAG-GMCAO), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Clinique universitaire de chirurgie orthopédique et de traumatologie du sport, hôpital Sud, CHU de Grenoble, avenue de Kimberley, 38130 Échirolles, France, parent, and Queens Elizabeth Hospital [Birmingham]
Subjects: musculoskeletal diseases, Male, Reoperation, medicine.medical_specialty, Computer-assisted surgery, Knee Joint, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Osteoarthritis, Osteotomy, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, High tibial osteotomy, Unicompartmental knee arthroplasty, medicine, Humans, Orthopedics and Sports Medicine, Tibia, Arthroplasty, Replacement, Knee, Aged, Retrospective Studies, 2. Zero hunger, 030203 arthritis & rheumatology, 030222 orthopedics, business.industry, Retrospective cohort study, Recovery of Function, Middle Aged, Osteoarthritis, Knee, medicine.disease, Arthroplasty, Surgery, Radiography, Treatment Outcome, Surgery, Computer-Assisted, Female, business, Follow-Up Studies
Abstract: AimsThe role of high tibial osteotomy (HTO) is being questioned by the use of unicompartmental knee arthroplasty (UKA) in the treatment of medial compartment femorotibial osteoarthritis. Our aim was to compare the outcomes of revision HTO or UKA to a total knee arthroplasty (TKA) using computer-assisted surgery in matched groups of patients.Patients and MethodsWe conducted a retrospective study to compare the clinical and radiological outcome of patients who underwent revision of a HTO to a TKA (group 1) with those who underwent revision of a medial UKA to a TKA (group 2). All revision procedures were performed using computer-assisted surgery. We extracted these groups of patients from our database. They were matched by age, gender, body mass index, follow-up and pre-operative functional score. The outcomes included the Knee Society Scores (KSS), radiological outcomes and the rate of further revision.ResultsThere were 20 knees in 20 patients in each group. The mean follow-up was 4.1 years (2 to 18.7). The mean total KSS at last follow-up was 185.7 (standard deviation (sd) 5) in group 1 compared with 176.5 (sd 11) for group 2 (p = 0.003). The mean hip-knee-ankle angle was 180.2° (sd 3.2°) in group 1 and 179.0° (sd 2.2°) in group 2. No revision was required.ConclusionWe found that good functional and radiological outcomes followed revision of both HTO and UKA to TKA. Revision of HTO showed significantly better functional outcomes. These results need to be further investigated by a prospective randomised controlled trial involving a larger group of patients. Cite this article: Bone Joint J 2016;98-B:1620–4.
Published: 2016

28. Gilles de la Tourette syndrome - A treatable condition?

Author: Andreas Hartmann, D. Martino, Tytus Murphy, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Queen Elizabeth Hospital, Queens Elizabeth Hospital [Birmingham], International Parkinson's Centre of Excellence [Londres], King's College Hospital (KCH)-King‘s College London, Tourette SyndromeClinic, Great Ormond Street Hospital for Children [London] (GOSH), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Neuroradiologie [CHU Pitié-Salpêtrière], Centre De Référence National 'Syndrome Gilles de la Tourette', Pôle des Maladies du Système Nerveux [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)
Subjects: medicine.medical_specialty, Gilles de la Tourette syndrome, Psychotherapist, Tics, media_common.quotation_subject, Deep Brain Stimulation, Medical Marijuana, Tourette syndrome, Neurosurgical Procedures, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, Optimism, Neurodevelopmental disorder, Quality of life (healthcare), mental disorders, Pharmacothérapie, medicine, Humans, Molecular Targeted Therapy, Vocal tics, Psychiatry, Syndrome Gilles de la Tourette, media_common, Psychothérapie, Stimulation cérébrale profonde, Patient Selection, medicine.disease, 3. Good health, 030227 psychiatry, Psychotherapy, Neurology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), Neurosurgery, Psychology, 030217 neurology & neurosurgery, Antipsychotic Agents, Tourette Syndrome
Abstract: International audience; IntroductionGilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by chronic motor and vocal tics. Psychiatric comorbidity is frequent but does not enter into the official classification of the syndrome. In the present article, we will focus on treatment options for tics.MethodsWe have reviewed the relevant literature on treatment of tics and GTS, especially in the period from 2011–2016 since the publication of the European Society for the Study of Tourette Syndrome (ESSTS) treatment guidelines in 2011.ResultsWe present current and up-to-date approaches in psychotherapy, pharmacotherapy and neurosurgery for GTS with an outlook for the upcoming years.ConclusionsAlthough many patients and health-care professionals seem to view tics and/or GTS as difficult to treat, or believe that treatment requires severe side effects with reduction in quality of life, we wish to convey that there is cause for optimism, both with regard to available treatment modalities and future therapeutic developments.; IntroductionLe syndrome Gilles de la Tourette (SGT) est un trouble neurodévelopmental caractérisé par la présence chronique de tics moteurs et vocaux. Les comorbidités psychiatriques sont fréquentes mais ne font pas partie de la définition officielle du SGT. Dans l’article présent, nous nous focaliserons sur les traitements anti-tics.MéthodesNous avons analysé la littérature relevante concernant le traitement des tics et du SGT, en particulier couvrant la période de 2011–2016, c’est-à-dire depuis la publication des guidelines de traitement européens par la European Society for the Study of Tourette Syndrome (ESSTS) en 2011.RésultatsNous présentons les approches courantes sur les traitements anti-tics en psychothérapie, pharmacothérapie et neurochirurgie ainsi que les perspectives d’évolution dans ces domaines.ConclusionsMalgré le fait que nombreux patients et professionnels de santé estiment le traitement des tics et/ou du SGT difficile, ou se focalisent sur les risques et effets secondaires potentiels, nous souhaitons mettre en avant une vision optimiste, aussi bien concernant le présent que les évolutions futures.
Published: 2016

29. Gilles de la Tourette syndrome – A treatable condition?

Author: Hartmann, A., Martino, D., Murphy, T., Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Neuroradiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Centre De Référence National 'Syndrome Gilles de la Tourette', Pôle des Maladies du Système Nerveux [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Queen Elizabeth Hospital, Queens Elizabeth Hospital [Birmingham], International Parkinson's Centre of Excellence [Londres], King's College Hospital (KCH)-King‘s College London, Tourette SyndromeClinic, Great Ormond Street Hospital for Children [London] (GOSH), HAL-UPMC, Gestionnaire, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Centre de Référence 'Syndrome Gilles de la Tourette' [CHU Pitié-Salpêtrière] (CRMR SGT)
Subjects: Psychotherapy, Psychothérapie, Gilles de la Tourette syndrome, Stimulation cérébrale profonde, Pharmacothérapie, Tics, Deep brain stimulation, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Syndrome Gilles de la Tourette, Pharmacotherapy
Abstract: IntroductionGilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by chronic motor and vocal tics. Psychiatric comorbidity is frequent but does not enter into the official classification of the syndrome. In the present article, we will focus on treatment options for tics.MethodsWe have reviewed the relevant literature on treatment of tics and GTS, especially in the period from 2011–2016 since the publication of the European Society for the Study of Tourette Syndrome (ESSTS) treatment guidelines in 2011.ResultsWe present current and up-to-date approaches in psychotherapy, pharmacotherapy and neurosurgery for GTS with an outlook for the upcoming years.ConclusionsAlthough many patients and health-care professionals seem to view tics and/or GTS as difficult to treat, or believe that treatment requires severe side effects with reduction in quality of life, we wish to convey that there is cause for optimism, both with regard to available treatment modalities and future therapeutic developments., IntroductionLe syndrome Gilles de la Tourette (SGT) est un trouble neurodévelopmental caractérisé par la présence chronique de tics moteurs et vocaux. Les comorbidités psychiatriques sont fréquentes mais ne font pas partie de la définition officielle du SGT. Dans l’article présent, nous nous focaliserons sur les traitements anti-tics.MéthodesNous avons analysé la littérature relevante concernant le traitement des tics et du SGT, en particulier couvrant la période de 2011–2016, c’est-à-dire depuis la publication des guidelines de traitement européens par la European Society for the Study of Tourette Syndrome (ESSTS) en 2011.RésultatsNous présentons les approches courantes sur les traitements anti-tics en psychothérapie, pharmacothérapie et neurochirurgie ainsi que les perspectives d’évolution dans ces domaines.ConclusionsMalgré le fait que nombreux patients et professionnels de santé estiment le traitement des tics et/ou du SGT difficile, ou se focalisent sur les risques et effets secondaires potentiels, nous souhaitons mettre en avant une vision optimiste, aussi bien concernant le présent que les évolutions futures.
Published: 2016

30. Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture

Author: Masayuki Matsushita, Stephanie Burger-Stritt, Harald Schulze, Michael Laffan, Susanna Zierler, Rémi Favier, Michele P. Lambert, Paola Ballerini, Simon Stritt, Silvia Ferioli, Lorenz Mittermeier, Paquita Nurden, Sanjeev K. Gotru, Bernhard Nieswandt, Marie Favier, Thomas Gudermann, Judith M.M. van Eeuwijk, Alan T. Nurden, Ernest Turro, Attila Braun, Vladimir Chubanov, University of Würzburg, CHU Bordeaux [Bordeaux], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Gustave Roussy (IGR), Hématopoïèse normale et pathologique (U1170 Inserm), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition, obésité et risque thrombotique (NORT), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ludwig Maximilians University of Munich, Hôpital Xavier Arnozan, Children’s Hospital of Philadelphia (CHOP ), University of Pennsylvania, Department of Haematology, Queens Elizabeth Hospital [Birmingham], NHS Blood and Transplant, Medical Research Council, NIHR BioResource - Rare Diseases, Cambridge University Hospitals (CUH), University Hospital of Würzburg, University of the RyuKyus, Partenaires INRAE, Imperial College London, Centre for Haematology, Hammersmith Campus, Munich Heart Alliance, German Center for Lung Research, Deutsche Forschungsgemeinschaft [SFB 688, TRR 152], German Excellence Initiative to the Graduate School of Life Sciences, University of Wurzburg, European Commission, NIHR, BHF [RP-PG-0310-1002, RG/09/12/28096], Imperial College London Biomedical Research Centre, Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ludwig-Maximilians University [Munich] (LMU), ProdInra, Migration, and Medical Research Council (MRC)
Subjects: 0301 basic medicine, [SDV]Life Sciences [q-bio], General Physics and Astronomy, DISEASE, Transient receptor potential channel, Mice, Megakaryocyte, ACTOMYOSIN CONTRACTILITY, Homeostasis, Platelet, Magnesium, Thrombopoiesis, Cytoskeleton, Multidisciplinary, Nonmuscle Myosin Type IIA, KINASE TRPM7, 3. Good health, Cell biology, Multidisciplinary Sciences, [SDV] Life Sciences [q-bio], MEGAKARYOCYTE, medicine.anatomical_structure, Science & Technology - Other Topics, Megakaryocytes, Blood Platelets, MIGRATION, Platelet disorder, Science, TRPM Cation Channels, PLATELET DISORDERS, Biology, Protein Serine-Threonine Kinases, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, TRPM7, MD Multidisciplinary, medicine, Animals, Humans, ddc:610, PROPLATELET FORMATION, Science & Technology, MUTATIONS, General Chemistry, Thrombocytopenia, 030104 developmental biology, Mutant Proteins
Abstract: Mg2+ plays a vital role in platelet function, but despite implications for life-threatening conditions such as stroke or myocardial infarction, the mechanisms controlling [Mg2+]i in megakaryocytes (MKs) and platelets are largely unknown. Transient receptor potential melastatin-like 7 channel (TRPM7) is a ubiquitous, constitutively active cation channel with a cytosolic α-kinase domain that is critical for embryonic development and cell survival. Here we report that impaired channel function of TRPM7 in MKs causes macrothrombocytopenia in mice (Trpm7fl/fl-Pf4Cre) and likely in several members of a human pedigree that, in addition, suffer from atrial fibrillation. The defect in platelet biogenesis is mainly caused by cytoskeletal alterations resulting in impaired proplatelet formation by Trpm7fl/fl-Pf4Cre MKs, which is rescued by Mg2+ supplementation or chemical inhibition of non-muscle myosin IIA heavy chain activity. Collectively, our findings reveal that TRPM7 dysfunction may cause macrothrombocytopenia in humans and mice., Although Mg2+ is vital for platelet activation and aggregation, its regulation in these cells is still largely unknown. Here, the authors show that TRPM7, a cation channel and a protein kinase, regulates thrombopoiesis and platelet size by affecting the cytoskeleton of these cells in mice and humans.
Published: 2016

31. 'Hemispherical asymmetry in the Meyer's Loop': a prospective study of visual-field deficits in 105 cases undergoing anterior temporal lobe resection for epilepsy

Author: Andrew W. McEvoy, Panitha Jindahra, Merle James-Galton, Tak Lap Poon, N. U. Owase Jeelani, Gordon T. Plant, William Harkness, Paul Kabasele, John Stevens, Mandeep S. Tamber, John S. Duncan, Great Ormond Street Hospital for Children [London] (GOSH), Department of Clinical and Experimental Epilepsy, University College of London [London] (UCL)-Institute of Neurology, The Hospital for sick children [Toronto] (SickKids), Queen Elizabeth Hospital, Queens Elizabeth Hospital [Birmingham], The National Hospital For Neurology and Neurosurgery, and The National Hospital for Neurology and Neurosurgery
Subjects: Adult, medicine.medical_specialty, genetic structures, Vision Disorders, Functional Laterality, Temporal lobe, Central nervous system disease, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, medicine, Humans, Visual Pathways, Epilepsy surgery, Prospective Studies, Prospective cohort study, EPILEPSY, Amygdalohippocampectomy, Middle Aged, Anterior Temporal Lobectomy, medicine.disease, Magnetic Resonance Imaging, ANATOMY, Surgery, Psychiatry and Mental health, VISION, medicine.anatomical_structure, Epilepsy, Temporal Lobe, Laterality, 030221 ophthalmology & optometry, Neurology (clinical), Visual Fields, Psychology, 030217 neurology & neurosurgery, Optic radiation
Abstract: Objectives Visual-field deficits following temporal lobe surgery have been reported in the literature. In this prospective study, the authors analyse their experience of visual-field deficits in 105 consecutive cases undergoing temporal-lobe surgery performed by a single surgeon, with particular consideration to the laterality of the deficit and its functional implications. Methods 105 consecutive patients undergoing an anterior temporal lobe resection for epilepsy, between March 1998 and June 2004, were selected. The patient population had a mean age of 35 years (range 19–60 years); 53 had a left-sided resection and 52 a right-sided resection. 91 patients had mesial temporal sclerosis, three gangliogliomas, four dysembryoplastic neuroepithelial tumours (DNETs), two neurocytomas and two cavernomas, and in three cases the histology was inconclusive. Pre- and postoperative visual-field tests were obtained using the Humphrey Esterman binocular functional test for all cases. The test was set to stimulus white III, with a single intensity of 10 DB on the background of 31.5 ASB for all patients. A minimum follow-up period of 12 months postsurgery was employed. Postoperative MRI scans were carried out on all patients. 60 scans were randomly selected, and the extent of temporal lobe resection calculated manually for each. Results Of the 105 cases, 16 patients had a visual-field deficit postoperatively which was not present preoperatively: 12 following a left and four following a right-sided resection. The OR for incurring a postoperative visual-field defect following left versus right-sided surgery was 3.51 (95% CI 1.05 to 11.73, p=0.04). In four patients, the deficit was severe enough to preclude them from driving in the UK (three left- and one right-sided resection). There was no association between the extent of tissue resection and the incidence of postoperative visual-field deficits. Conclusions This study suggests left-/right-hemispherical asymmetry in the Geniculocalcarine tracts with field deficits being 3.5 times more likely following left-sided anterior temporal lobe resections compared with right-sided resections. This has significant implications on counselling patients for these procedures. MR tractography may provide an anatomical substrate for these clinical findings, perhaps revealing a more anterior course of the optic radiations within the temporal lobe in one hemisphere versus the other.
Published: 2010

32. The Gaia mission

Author: Belokurov, V., Troisi, L., Zurbach, C., Krone-Martins, A., Blagorodnova, N., Prusti, T., Guerra, R., Tapiador, D., Thuillot, W., Aerts, C., De Angeli, F., Hobbs, D., Martino, M., Ayache, L., Virtanen, J., Fonti, A., Nienartowicz, K., Pieniluoma, T., Molinaro, M., Mora, A., Irwin, M., Baker, S., Jordi, C., Abbas, U., Olias Sanz, A., Gai, M., Masana, E., Garofalo, A., Cropper, M., Gómez, M., Høg, E., Bendjoya, P., Ulla, A., Barros, M., Montegriffo, P., Vecchiato, A., Gebran, M., Fustes, D., Bigot, L., Helmi, A., Anderson, R., Seabroke, M., Di Matteo, P., Lanza, F., Fraile, E., Ruiz-Dern, L., Barbier, A., Segransan, D., Rauw, G., David, P., Burgess, P., Ribeiro, R., Van Leeuwen, F., Smareglia, R., Kutka, A., Gavras, P., Salgado, J., Gosset, E., Arsenijevic, V., Pourbaix, D., Hernández, J., Hypki, A., De Laverny, P., Gallegos, J., Altavilla, G., Molina, D., Barrado Y Navascués, D., Marchal, O., Sagristà Sellés, T., Milligan, J., Sciacca, E., Bello García, A., Bombrun, A., Vallenari, A., Drazinos, P., Barata, C., Karampelas, A., Anglada Varela, E., Spagna, A., Creevey, O., David, M., Munari, U., Arcay, B., Isasi Parache, Y., Serraller Vizcaino, I., Schultheis, M., Brunet, P., Prat, G., Andrae, R., Ripepi, V., Burgon, R., Pagano, I., Lopez-Lozano, A., Gracia-Abril, G., Barache, C., Bouy, H., Blasco, C., Gilmore, G., Andrei, H., Iannicola, G., Tsalmantza, P., Wallut, J.-M., Bragaglia, A., Brown, S., Amorim, A., Roelens, M., Blomme, R., Martinez-Rubi, O., Taris, F., Balaguer-Núñez, L., Pasquato, E., Frézouls, B., Janotto, M., Vicente, D., Hambly, C., Galluccio, L., Holland, G., Van Reeven, W., Charvet, P., Palacin, H., Peltzer, C., Blanco-Cuaresma, S., De Bruijne, H., Garé, P., Rimoldini, L., Mowlavi, N., Brüsemeister, T., Soria Nieto, S., Korn, J., Zschocke, S., Holl, B., Palaversa, L., De Luise, F., Luri, X., Solano, E., Leroux, F., Stampa, U., Meynadier, F., Collins, S., Liu, C., Bourda, G., Mary, N., García-Torres, M., Comoretto, G., Bellei, G., Short, A., Arenou, F., Petit, J.-M., Ramos-Lerate, M., Chéreau, F., Carry, B., Gomes, M., Ortiz, P., Ranalli, P., Marinoni, S., Boch, T., Michalik, D., Bachchan, R., Delgado, H., Jasniewicz, G., Sarro, L., Budnik, F., Koubsky, P., Faye, F., Kontizas, M., Marchant, J., Vogt, S., Grux, E., Crosta, M., Klar, J., Plum, G., Kudryashova, M., Lister, A., Risquez, D., Kochukhov, O., Robin, C., Werner, D., Carlucci, T., Mercier, E., Holland, D., Trager, S., Allen, M., Pedrosa, R., Pecoraro, M., Charlot, P., Brown, A., Joliet, E., Weiler, M., Gueguen, A., Lanza, C., Ordénovic, C., García-Sedano, F., Randich, S., Rowell, N., Marschalkó, G., Yoldas, A., Spoto, F., Anglada-Escudé, G., Hodgkin, S., Carrion, Claire, Cantat-Gaudin, T., Fouesneau, M., Rambaux, N., Stephenson, C., Geyer, R., Campbell, H., Babusiaux, C., Altmann, M., Valentini, G., Wilkinson, M., Narbonne, J., Suess, F., Royer, F., Gallardo, E., De Felice, F., Voss, H., Monteiro, D., Pichon, B., Diakite, S., Martino, D., Evans, W., Barstow, M., Löffler, W., Fabricius, C., Park, P., Pailler, F., Damerdji, Y., Theil, S., Palmer, M., Burlacu, A., Bach, N., Lock, T., Walton, A., Silva, H., Astraatmadja, L., Rudolph, A., Cellino, A., Gerssen, J., O’Mullane, W., Bianchi, L., Del Pozo, E., Fries, A., Mestre, A., Girona, S., Teixeira, R., Filippi, F., Pauwels, T., Siopis, C., Siebert, A., Schnorhk, A., Managau, S., Siddiqui, H., Osborne, P., Steele, A., Kordopatis, G., Carrasco, J., Jonckheere, A., Plachy, E., Busso, G., Castañeda, J., Makarov, V., Sarri, G., Hestroffer, D., Domingues, D., Galleti, S., Tur, D., González-Núñez, J., Segol, M., De Teodoro, P., Bucciarelli, B., Varadi, M., Soffel, M., Fedorets, G., Terrett, D., Moniez, M., Marconi, M., Via, Y., Macdonald, I., Halbwachs, J., Allende Prieto, C., Muinonen, K., Eynard Bontemps, G., Walmsley, G., Abreu Aramburu, A., Gúrpide, A., Terrell, D., Loureiro, T., Panem, C., Guerrier, A., Paulsen, T., Delle Luche, C., Dubath, P., Antiche, E., Prša, A., Haywood, M., Mor, R., Prod’Homme, T., Licata, E., Guillout, P., De Ridder, J., Eyer, L., Hatzidimitriou, D., Péturaud, F., Borrachero, R., Souchay, J., Debosscher, J., Granvik, M., Recio-Blanco, A., Parsons, P., Bellazzini, M., Durán, J., Knude, J., Lobel, A., Nicastro, L., Mignard, F., Buzzi, R., Slezak, E., Shih, C., Riello, M., Kim, W., Morley, T., Fienga, A., Votruba, V., Gomboc, A., Dell’Oro, A., Tiede, C., Jevardat De Fombelle, G., Nelemans, G., Jofré, P., Nguyen, A., Žerjal, M., Szabados, L., Kolenberg, K., Kos, J., Martayan, C., Riva, A., Süveges, M., Zucker, S., Renk, F., Hoar, J., Smart, R., Crowley, C., Bono, G., Hutton, A., Le Poncin-Lafitte, C., Segovia, J., Els, S., Solitro, F., Miranda, H., Bernstein, H., Mann, R., Frémat, Y., Wevers, T., Heiter, U., Matijevič, G., Berthier, J., Russo, F., Giuffrida, G., Millar, R., Balm, P., Delbo, M., Lindegren, L., Keil, R., Mulone, F., Weingrill, K., Chassat, F., Falcão, J., Farràs Casas, M., Huckle, H., Livanou, E., González-Vidal, J., Nordlander, T., Van Hemelryck, E., Szegedi-Elek, E., Garralda, N., Van Hamme, W., Bijaoui, A., Sinachopoulos, D., Reylé, C., Sarasso, M., Martín-Fleitas, J., Raison, F., Molinaro, R., Wichmann, R., Rixon, G., Rocca-Volmerange, B., Pineau, F., Piersimoni, M., Torra, J., Soubiran, C., Lainey, V., Kull, I., Fodor, F., Erdmann, M., Berihuete, A., Collins, P., Enke, H., Pancino, E., Dafonte, C., Kohley, R., Passot, X., Ducourant, C., Lavigne, J., Dapergolas, A., Bressan, A., Richards, J., Allan, P., Loreggia, D., Distefano, E., Sosnowska, D., Valles, P., Ziaeepour, H., Marseille, M., López, M., De Cat, P., Allasia, W., Aguado, J., Dolding, C., Poels, J., Espina, M., Álvarez, M., Lorenz, D., Utrilla, E., Fabrizio, M., Chaoul, L., Bastian, U., Benson, K., Biermann, M., Antoja, T., Pulone, L., Poinsignon, V., Katz, D., Hofmann, W., Findeisen, K., Via, T., Faigler, S., Rebordao, J., Huc, C., Barblan, F., Sadowski, G., Taylor, M., Sordo, R., Lebouquin, D., Read, A., Butkevich, A., Van Elteren, A., Manteiga, M., Hauser, M., Jonker, P., Voutsinas, S., Morbidelli, R., Fuchs, J., Bouquillon, S., Molnár, L., Gutiérrez-Sánchez, R., Accart, S., Vachier, F., Cocozza, G., Marshall, J., Sahlmann, J., Kochoska, A., De March, R., Portell, J., Tanga, P., Edvardsson, B., Osorio, J., Antón, S., Pigozzi, E., Alves, J., Kowalczyk, A., Chiavassa, A., Savietto, H., Sembay, S., Veljanoski, J., Klagyivik, P., Tur, C., Ecale, E., Bienaymé, O., Dos Anjos, S., Leccia, S., Messineo, R., Serpell, E., Guy, L., Harrison, L., Bailer-Jones, L., Cheek, N., Dzigan, Y., Ordieres-Meré, J., Tingley, B., Poujoulet, E., Cowell, S., Ragaini, S., De Torres, A., Marie, J., Baroni, M., Lenhardt, H., Osinde, J., Lemaitre, V., Pereira, J., Thévenin, F., Di Marco, F., Ruiz-Fuertes, M., Klioner, S., Darmigny, E., Ouzounis, A., Julbe, F., Busonero, D., Grebel, E., Jordan, S., Cacciari, C., Clotet, M., Stoev, H., Vaccari, M., Moitinho, A., Rago, S., Fernique, P., Ordóñez-Blanco, D., Veltz, L., Liao, S., Escolar, D., Messina, S., Drimmel, R., Lindstrøm, H., Heyrovsky, A., Guiraud, J., Breddels, M., Garabato, D., Rosen, S., Mcmillan, J., Straižys, V., Gardiol, D., Lebreton, Y., Mazeh, T., Beck, M., Bunclark, P., Peralta, J., Ter Linden, M., Mantelet, G., Morel, T., Furnell, R., Sartoretti, P., Jean-Antoine-Piccolo, A., Van Leeuwen, M., Steidelmüller, H., Azaz, S., Pentikäinen, H., Kolka, I., Wyrzykowski, Ł., Clementini, G., Charnas, J., Alecu, A., Kontizas, E., Figueras, F., Fyfe, D., Crifo, F., Jansen, F., Delgado, A., Costigan, G., Fernández-Hernández, J., Koposov, S., Valette, V., Surdej, J., Massart, B., Castellani, M., Morgenthaler, S., Regibo, S., Delchambre, L., Fraser, M., Cancelliere, R., Boudreault, S., Marrese, P., Chemin, L., Lattanzi, M., Bramante, L., Gómez, A., Bellas-Velidis, I., Leclerc, N., Federici, L., Cuypers, J., Hunt, S., Cambras, J., Brouillet, N., Icardi, V., Tauran, G., Cross, J., Atzei, A., Corcione, L., De Zeeuw, P., Lebzelter, T., Lammers, U., Ocvirk, P., Smith, M., Magalhães Fernandes, T., Carret, C., Smith, C., Sozzetti, A., Billebaud, F., De Souza, R., De Boer, S., Zwitter, T., Lacoste-Seris, F., Muraveva, T., Jorissen, A., Pagani, C., Smith, W., Musella, I., Haigron, R., Caffau, E., Panuzzo, P., Oszkiewicz, D., Garcia-Reinaldos, M., Noval, L., González-Marcos, A., Salguero, E., Lecoeur-Taibi, I., Becciani, U., Whitehead, G., Bonfigli, M., Fabre, C., Mignot, S., O’Flaherty, S., Buonanno, R., Morris, D., Carrion, C., Collaboration, Gaia, De Bruijne, J.H.J., European Space Research and Technology Centre (ESTEC), Agence Spatiale Européenne = European Space Agency (ESA), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Zentrum für astronomie, Universität Heidelberg [Heidelberg] = Heidelberg University, Department of nuclear medicine, Haukeland University Hospital, University of Bergen (UiB)-University of Bergen (UiB), Department of Clinical Medicine, University of Bergen (UiB), Centre for Research in Earth and Space Science [Toronto] (CRESS), York University [Toronto], Geneva Observatory, Université de Genève = University of Geneva (UNIGE), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Jennifer Milligan, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES), Institute of Astronomy [Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Astronomische Rechen-Institut [Heidelberg] (ARI), Zentrum für Astronomie der Universität Heidelberg (ZAH), Universität Heidelberg [Heidelberg] = Heidelberg University-Universität Heidelberg [Heidelberg] = Heidelberg University, University of California [San Diego] (UC San Diego), University of California (UC), INAF - Osservatorio Astronomico di Bologna (OABO), Istituto Nazionale di Astrofisica (INAF), Institut de Ciencies del Cosmos (ICCUB), Universitat de Barcelona (UB), European Space Astronomy Centre (ESAC), Systèmes de Référence Temps Espace (SYRTE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Royal Observatory of Belgium [Brussels] (ROB), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université de Picardie Jules Verne (UPJV), University of Edinburgh, Laboratório de Ictiologia e Pesca, Universidade Federal de Rondônia [Brésil] (UNIR), Institute of Astronomy [Cambridge], University of Cambridge [UK] (CAM), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université d'Athènes (UOA), SIM/IDL Faculdade de Ciências da Universidade de Lisboa (FCUL), University of Lisboa, Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Florida State University [Tallahassee] (FSU), Department of Computer Science, University of York [York, UK], INAF - Osservatorio Astrofisico di Torino (OATo), Universidad de Murcia, EURIX Software Innovators, INTA (INTA), INTA, CESAM, Universidade de Aveiro, South Iceland Research Centre, University of Iceland [Reykjavik], United States Geological Survey [Reston] (USGS), Récepteurs et Canaux Ioniques Membranaires (RCIM), Université d'Angers (UA)-Institut National de la Recherche Agronomique (INRA), Department of Medicine, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Institute of Environmental Assessment and Water Research (IDAEA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Thales Services, THALES [France], Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Department of Physics and Astronomy [Leicester], University of Leicester, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Observatoire Astronomique de l'Université de Genève (ObsGE), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), School of Physical Sciences [Milton Keynes], Faculty of Science, Technology, Engineering and Mathematics [Milton Keynes], The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre de Modélisation Mathématique / Centro de Modelamiento Matemático (CMM), Centre National de la Recherche Scientifique (CNRS), Centre d'étude spatiale des rayonnements (CESR), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Observatoire de Haute-Provence (OHP), Institut Pythéas (OSU PYTHEAS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS), Australian Institute of Sport, International Parkinson's Centre of Excellence [Londres], King's College Hospital (KCH)-King‘s College London, Queen Elizabeth Hospital, Queens Elizabeth Hospital [Birmingham], Hospital Israelita Albert Einstein [São Paulo, Brazil], Department of Computing, Electronics and Mechatronics, Universidad de las Américas [Puebla] (UDLAP), Agenzia Spaziale Italiana (ASI), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Astrometry, Istituto Nazionale di Astrofisica (INAF)-Istituto Nazionale di Astrofisica (INAF), Universidade de Lisboa = University of Lisbon (ULISBOA), Department of Mechanical, Informatics and Aerospace Engineering [León], Universidad de León [León], Department of Physics [Athens], National and Kapodistrian University of Athens (NKUA), Departament Llenguatges i Sistemes Informatics, Universitat Politècnica de Catalunya [Barcelona] (UPC), Department of Astrophysics [Nijmegen], Institute for Mathematics, Astrophysics and Particle Physics (IMAPP), Radboud University [Nijmegen]-Radboud University [Nijmegen], SRON Netherlands Institute for Space Research (SRON), Institut d'Astronomie et d'Astrophysique [Bruxelles] (IAA), Université libre de Bruxelles (ULB), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], INAF - Osservatorio Astrofisico di Catania (OACT), Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Shanghai Astronomical Observatory [Shanghai] (SHAO), Chinese Academy of Sciences [Beijing] (CAS), Astrophysics Research Institute [Liverpool] (ARI), Liverpool John Moores University (LJMU), INAF - Osservatorio Astronomico di Capodimonte (OAC), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Center for Functional Analysis, Faculdade de Ciencias da Universidade de Lisboa, Istituto Nazionale di Astrofisica (Istituto Nazionale di Astrofisica), Istituto Nazionale di Fisica Nucleare (INFN), INAF - Osservatorio Astronomico di Trieste (OAT), Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique et de Géophysique [Liège], Université de Liège, Institute for Astronomy [Edinburgh] (IfA), Botanique et Modélisation de l'Architecture des Plantes et des Végétations (UMR AMAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), GIRM, Instituto Politécnico de Leiria, LeanXcale [Madrid], Service de la Radio-Oncologie [Saint-Herblain], Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER-UNICANCER, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Neurologie [Hôpitaux Civils de Colmar], Hôpitaux Civils Colmar, Institute of Hepatology, Birkbeck College [University of London]-Foundation for Liver Research, Département Réseaux, Information, Multimédia (RIM-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre G2I, European Space Operations Center (ESOC), Équipes de Recherches Interlangues : Mémoires, Identités, Territoires (ERIMIT), Université de Rennes 2 (UR2), Université Paris 1 Panthéon-Sorbonne - UFR d'Économie (UP1 UFR02), Université Paris 1 Panthéon-Sorbonne (UP1), Department of Physics [Durham], University of New Hampshire (UNH), Spanish Virtual Observatory - Observatorio Virtual Español (SVO), Spanish Virtual Observatory - Observatorio Virtual Español, Departamento de Astrofisica [Madrid], Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Department of Computer Science [Verona] (UNIVR | DI), Università degli studi di Verona = University of Verona (UNIVR), Geophysical Laboratory [Carnegie Institution], Carnegie Institution for Science, Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Instituto de Astronomia, Geofísica e Ciências Atmosféricas [São Paulo] (IAG), Universidade de São Paulo = University of São Paulo (USP), University of Paderborn, Karl-Franzens-Universität Graz, HE Space Operations BV for ESA/ESTEC, Institute of Hydrology, University of Freiburg [Freiburg], Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Department of Computer Science [Beer-Sheva], Ben-Gurion University of the Negev (BGU), CENTRA-SIM, IDL-Faculdade de Ciencias da Universidade de Lisboa, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Laboratori de Bromatologia i Toxicologia, Facultat de Farmàcia, Universitat de València (UV), Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, Manomet Center for Conservation Sciences, Unite mixte de recherche en droit comparé (UMRDC), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Canadian Food Inspection Agency (CFIA), Institut Jean-Nicod (IJN), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Département de Philosophie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University (UNESP), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Droit Privé et de Sciences Criminelles (LDPSC), Aix Marseille Université (AMU), Department of Physics and Astronomy [Clemson], Clemson University, Departamento de Producción Animal y Ciencia de los Alimentos, University of Zaragoza - Universidad de Zaragoza [Zaragoza], Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Lineberger Comprehensive Cancer Center (UNC Lineberger), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC)-University of North Carolina System (UNC), Uppsala University, Center for Ultrafast Optical Science, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Department of Psychiatry, Seaver Autism Center for Research and Treatment, European Southern Observatory (ESO), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Leibniz Institute for Astrophysics Potsdam (AIP), Innovalia Association, University of Las Palmas de Gran Canaria (ULPGC), Department of Physics [Helsinki], Falculty of Science [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Nordic Optical Telescope (NOT), Instituto de Astrofisica de Canarias (IAC), Royal Institute of Technology [Stockholm] (KTH ), Leiden Observatory [Leiden], Universiteit Leiden, Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Leibniz-Institut für Astrophysik Potsdam (AIP), Universidade de Coimbra [Coimbra], Southwest Research Institute [Boulder] (SwRI), Max-Planck-Institut für Astronomie (MPIA), University of the Western Cape (UWC), Istituto di Radioastronomia [Bologna] (IRA), Observatoire astronomique de Strasbourg (OAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Centre d'études spatiales de la biosphère (CESBIO), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Lohrmann Observatory, Technische Universität Dresden = Dresden University of Technology (TU Dresden), European Space Agency (ESA), PSL Research University (PSL)-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg], University of Bergen (UIB)-University of Bergen (UIB), University of Bergen (UIB), University of Geneva [Switzerland], Agence Spatiale Européenne (ESA), Human Cancer Genetics Program, Comprehensive Cancer Center-College of Medicine and Public Health [Colombus], M2A 2016, Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Ecologie, Evolution, Symbiose (EES), Ecologie et biologie des interactions (EBI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), University of Illinois at Urbana Champaign (UIUC), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System-University of Illinois System, University of California, Department of Biomedical Sciences, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Nelson Mandela Metropolitan University [Port Elizabeth, South Africa], Laboratorio de Inmunologıa y Virologıa, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolas de los Garza, Solvay (France), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), PSL Research University (PSL)-PSL Research University (PSL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Royal Observatory of Belgium [Brussels], Università di Bologna [Bologna] (UNIBO), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Universidade Federal de Rondônia, Institute of Astronomy, Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Department of Pathology and Cell Biology, Columbia University [New York], AUTRES, EURIX (.), Laboratoire Récepteurs et Canaux Ioniques Membranaires (RCIM), IDAEA-CSIC, THALES, Laboratoire d'Ecologie Alpine (LECA), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Joseph Fourier - Grenoble 1 (UJF)-Université Grenoble Alpes (UGA), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Genève (UNIGE), Université Grenoble Alpes - UFR Langage, lettres et arts du spectacle, information et communication - Dpt Lettres et arts du spectacle (UGA UFR LLASIC LAS), Université Grenoble Alpes (UGA), Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), FORMATION STELLAIRE 2016, The Open University [Milton Keynes] (OU), CICEnergigune, Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Hospital Israelita Albert Einstein, Pneumologia Ospedale San Paolo, Università degli studi di Milano [Milano], Activité Physique, Muscle, Santé (EA4488), Université de Lille, Droit et Santé, Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' [Rome], Biologie Intégrative des Populations, École pratique des hautes études (EPHE)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Federal University of Para - Universidade Federal do Para [Belem - Brésil], Sciences Pour l'Oenologie (SPO), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD [Nouvelle-Calédonie])-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), National and Kapodistrian University of Athens = University of Athens (NKUA | UoA), Heckscher-Klinikum, Radboud university [Nijmegen]-Radboud university [Nijmegen], Institut d'Astronomie et d'Astrophysique, Université Libre de Bruxelles [Bruxelles] (ULB), Biologie et pharmacologie des plaquettes sanguines: hémostase, thrombose, transfusion (http://www.u949.inserm.fr/), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS, Virulence bactérienne et maladies infectieuses (VBMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Clermont-Ferrand (ICCF), Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Sigma CLERMONT (Sigma CLERMONT), Atmel Corporation (ATMEL), ATMEL, Probabilités, statistique, physique mathématique (PSPM), Institut Camille Jordan [Villeurbanne] (ICJ), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Institut Non Linéaire de Nice Sophia-Antipolis (INLN), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sorbonne - Paris 4 - École supérieure du professorat et de l'éducation - Académie de Paris (ESPE Paris), Université Paris-Sorbonne (UP4), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), UCT/MRC Receptor Biology Unit, University of Cape Town, Mammal Research Institute, University of Pretoria [South Africa], Centre for Integrative Physiology, Physics and Materials Science Research Unit, University of Luxembourg, University of Luxembourg [Luxembourg], Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), National Institute for Nuclear Physics (INFN), Departamento de Microbiología y Parasitología [Lugo, Spain], Laboratorio de Referencia de E. coli [Lugo, Spain] (LREC), Universidade de Santiago de Compostela [Spain] (USC )-Universidade de Santiago de Compostela [Spain] (USC ), CERFACS [Toulouse], Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Molecular Neuroimaging, RedZinc Services Ltd.[Dublin], Laboratoire de Physico -& Toxico Chimie des systèmes naturels (LPTC), Université Sciences et Technologies - Bordeaux 1-Centre National de la Recherche Scientifique (CNRS), Institut de Cancérologie de l'Ouest- ICO Gauducheau, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique (CNRS), Department of Biochemical and Chemical Engineering, Technische Universität Dortmund [Dortmund] (TU), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université Panthéon-Sorbonne - UFR d'Économie (UP1 UFR02), Université Panthéon-Sorbonne (UP1), Capital Normal University [Beijing], Department of Paleobiology [Washington], Smithsonian Institution, Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Università degli Studi di Verona, Carnegie Institution for Science [Washington], Instituto de Astronomia, Geofisica e Ciencias Atmosfericas [Sao Paulo] (IAG), Universidade de São Paulo (USP), HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Westfälische Wilhelms-Universität Münster (WWU), Max-Planck-Institut für Sonnensystemforschung (MPS), Université Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Centre universitaire de Cytométrie, Imagerie et Mathématiques (CIM), Université de Limoges (UNILIM)-CHU Limoges, Département de Philosophie - ENS Paris, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-École des hautes études en sciences sociales (EHESS)-Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS Paris), Universidade Estadual Paulista Júlio de Mesquita Filho [São José do Rio Preto] (UNESP), Laboratoire d'Etudes Sociolinguistiques sur les Contacts de Langues et la Politique Linguistique (LESCLAP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Lineberger Comprehensive Cancer Center, Centre de Recherches Pétrographiques et Géochimiques (CRPG), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, University of Helsinki-University of Helsinki, Institute of Space and Astronautical Science (ISAS), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Instituto Nacional de Engenharia, Tecnologia e Inovacco (INETI), Réhabilitation Chirurgicale mini-Invasive et Robotisée de l'Audition, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Otologie, Implants auditifs et Chirurgie de la base du crâne [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Sonoita Research Observatory, Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS), Institute of Physical Geodesy, sans affiliation, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Technische Universität Dresden (TUD), ITA, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg]-Universität Heidelberg [Heidelberg], Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut de Recherche pour le Développement (IRD), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Universidade de Lisboa (ULISBOA), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), University of Verona (UNIVR), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Arts et Métiers (ENSAM), HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Centre d'Etudes des Relations et Contacts Linguistiques et Littéraires - UR UPJV 4283 (CERCLL), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Universiteit Leiden [Leiden], University of the Western Cape, Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), European Space Research and Technology Centre ( ESTEC ), European Space Agency ( ESA ), University of Bergen ( UIB ) -University of Bergen ( UIB ), University of Bergen ( UIB ), Centre for Research in Earth and Space Science [Toronto] ( CRESS ), Agence Spatiale Européenne ( ESA ), Laboratoire d'Astrophysique de Bordeaux [Pessac] ( LAB ), Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Equipe EES, Ecologie et biologie des interactions ( EBI ), Université de Poitiers-Centre National de la Recherche Scientifique ( CNRS ) -Université de Poitiers-Centre National de la Recherche Scientifique ( CNRS ), Katholieke Universiteit Leuven ( KU Leuven ), University of Illinois at Urbana Champaign ( UIUC ), Departments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California, San Diego, La Jolla, CA 92093-0841, USA, Centre National d'Etudes Spatiales ( CNES ), University of Modena & Reggio-Emilia, Galaxies, Etoiles, Physique, Instrumentation ( GEPI ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Lagrange - Observatoire de la Côte d'Azur, Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), European Space Astronomy Centre ( ESAC ), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires ( EA 2992 ), Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Systèmes de Référence Temps Espace ( SYRTE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Centre National de la Recherche Scientifique ( CNRS ), Mullard Space Science Laboratory ( MSSL ), University College of London [London] ( UCL ), Institut de Mécanique Céleste et de Calcul des Ephémérides ( IMCCE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Università di Bologna [Bologna] ( UNIBO ), Institut d'astrophysique spatiale ( IAS ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Picardie Jules Verne ( UPJV ), University of Cambridge [UK] ( CAM ), Laboratoire Univers et Particules de Montpellier ( LUPM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université de Montpellier ( UM ), SIM/IDL Faculdade de Ciências da Universidade de Lisboa ( FCUL ), Lisboa university, Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) ( UTINAM ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Florida State University, INTA ( INTA ), United States Geological Survey [Reston] ( USGS ), Laboratoire Récepteurs et Canaux Ioniques Membranaires ( RCIM ), Université d'Angers ( UA ) -Institut National de la Recherche Agronomique ( INRA ), Mount Sinai School of Medicine, Universitat de Barcelona ( UB ), Laboratoire d'Ecologie Alpine ( LECA ), Centre National de la Recherche Scientifique ( CNRS ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Université Grenoble Alpes ( UGA ), Institut de Planétologie et d'Astrophysique de Grenoble ( IPAG ), Observatoire des Sciences de l'Univers de Grenoble ( OSUG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ), Université Côte d'Azur ( UCA ), Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Observatoire aquitain des sciences de l'univers ( OASU ), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Observatoire Astronomique de l'Université de Genève ( ObsGE ), Université de Genève ( UNIGE ), Université Grenoble Alpes - UFR Langage, lettres et arts du spectacle, information et communication - Dpt Lettres et arts du spectacle ( UGA UFR LLASIC LAS ), Université Grenoble Alpes ( UGA ), Institut de Chimie Moléculaire de Reims - UMR 7312 ( ICMR ), Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ) -Centre National de la Recherche Scientifique ( CNRS ) -SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ) -Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ) -Université de Reims Champagne-Ardenne ( URCA ) -Centre National de la Recherche Scientifique ( CNRS ), Centro de Astrobiologia [Madrid] ( CAB ), Instituto Nacional de Técnica Aeroespacial ( INTA ) -Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), The Open University [Milton Keynes] ( OU ), Laboratoire d'Electronique et des Technologies de l'Information ( CEA-LETI ), Université Grenoble Alpes [Saint Martin d'Hères]-Direction de Recherche Technologique (CEA) ( DRT (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Centre de Modélisation Mathématique / Centro de Modelamiento Matemático ( CMM ), Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherches Anglophones ( CREA (EA 370) ), Université Paris Nanterre ( UPN ), Centre d'étude spatiale des rayonnements ( CESR ), Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Observatoire de Haute-Provence ( OHP ), Institut Pythéas ( OSU PYTHEAS ), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture ( IRSTEA ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture ( IRSTEA ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), King's College Hospital-King‘s College London, Universidad de las Américas [Puebla] ( UDLAP ), Activité Physique, Muscle, Santé ( EA4488 ), Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies ( SISSA / ISAS ), INAF - Osservatorio Astronomico di Bologna ( OABO ), Istituto Nazionale di Astrofisica ( INAF ), Géoazur ( GEOAZUR ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de recherches sur la catalyse et l'environnement de Lyon ( IRCELYON ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), École pratique des hautes études ( EPHE ) -Centre National de la Recherche Scientifique ( CNRS ), INAF - Osservatorio Astrofisico di Torino ( OATo ), Istituto Nazionale di Astrofisica ( INAF ) -Istituto Nazionale di Astrofisica ( INAF ), Institut de Physique et Chimie des Matériaux de Strasbourg ( IPCMS ), Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ) -Matériaux et nanosciences d'Alsace, Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Réseau nanophotonique et optique, Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ), University of León, Observatoire astronomique de Strasbourg ( ObAS ), Université de Strasbourg ( UNISTRA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Sciences Pour l'Oenologie ( SPO ), Institut National de la Recherche Agronomique ( INRA ) -Institut de Recherche pour le Développement ( IRD [Nouvelle-Calédonie] ) -Université de Montpellier ( UM ) -Université Montpellier 1 ( UM1 ) -Institut national d’études supérieures agronomiques de Montpellier ( Montpellier SupAgro ), Department of Physics (Athens), Universitat Politècnica de Catalunya [Barcelona] ( UPC ), Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés ( LISBP ), Institut National de la Recherche Agronomique ( INRA ) -Institut National des Sciences Appliquées - Toulouse ( INSA Toulouse ), Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Centre National de la Recherche Scientifique ( CNRS ), Institute for Mathematics, Astrophysics and Particle Physics ( IMAPP ), SRON Netherlands Institute for Space Research ( SRON ), Université Libre de Bruxelles [Bruxelles] ( ULB ), The Institute of Environmental Medicine [Stockholm] ( IMM ), Biologie et pharmacologie des plaquettes sanguines: hémostase, thrombose, transfusion ( http://www.u949.inserm.fr/ ), Université de Strasbourg ( UNISTRA ) -EFS-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Virulence bactérienne et maladies infectieuses, Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Institut de Physique de Rennes ( IPR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de chimie et procédés pour l'énergie, l'environnement et la santé ( ICPEES ), Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Chimie de Clermont-Ferrand ( ICCF ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Sigma CLERMONT ( Sigma CLERMONT ) -Centre National de la Recherche Scientifique ( CNRS ), Chinese Academy of Sciences [Beijing] ( CAS ), Atmel Corporation ( ATMEL ), Institut Camille Jordan [Villeurbanne] ( ICJ ), Centre National de la Recherche Scientifique ( CNRS ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -École Centrale de Lyon ( ECL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon, Astrophysics Research Institute [Liverpool] ( ARI ), Liverpool John Moores University ( LJMU ), Institut Non Linéaire de Nice Sophia-Antipolis ( INLN ), École supérieure du professorat et de l'éducation - Académie de Paris ( ESPE Paris ), Université Paris-Sorbonne ( UP4 ), Matériaux, ingénierie et science [Villeurbanne] ( MATEIS ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ) -Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ), Istituto Nazionale di Astrofisica ( Istituto Nazionale di Astrofisica ), National Institute for Nuclear Physics ( INFN ), INAF - Osservatorio Astronomico di Trieste ( OAT ), Laboratoire SUBATECH Nantes ( SUBATECH ), Mines Nantes ( Mines Nantes ) -Université de Nantes ( UN ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratorio de Referencia de E. coli [Lugo, Spain] ( LREC ), Universidade de Santiago de Compostela [A Coruña, Spain] ( USC ) -Universidade de Santiago de Compostela [A Coruña, Spain] ( USC ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physico -& Toxico Chimie des systèmes naturels ( LPTC ), Université Sciences et Technologies - Bordeaux 1-Centre National de la Recherche Scientifique ( CNRS ), Botanique et Modélisation de l'Architecture des Plantes et des Végétations ( UMR AMAP ), Centre de Coopération Internationale en Recherche Agronomique pour le Développement ( CIRAD ) -Institut national de la recherche agronomique [Montpellier] ( INRA Montpellier ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD [France-Sud] ), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute ( ICM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique ( CNRS ), Département Réseaux, Information, Multimédia ( RIM-ENSMSE ), École des Mines de Saint-Étienne ( Mines Saint-Étienne MSE ), Institut Mines-Télécom [Paris]-Institut Mines-Télécom [Paris]-Centre G2I, European Space Operations Center ( ESOC ), Technische Universität Dortmund [Dortmund] ( TU ), Équipes de Recherches Interlangues : Mémoires, Identités, Territoires ( ERIMIT ), Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ), Université Panthéon-Sorbonne - UFR d'Économie ( UP1 UFR02 ), Université Panthéon-Sorbonne ( UP1 ), University of New Hampshire ( UNH ), Spanish Virtual Observatory - Observatorio Virtual Español ( SVO ), Centro de Astrobiologia, Departamento de Astrofisica ( INTA-CSIC ), Centro de Astrobiología, Konkoly Observatory, Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences [Budapest], Instituto de Astronomia, Geofisica e Ciencias Atmosfericas [Sao Paulo] ( IAG ), Universidade de São Paulo ( USP ), Physikalisch Technische Bundesanstalt ( PTB ), Laboratoire Electronique, Informatique et Image [UMR6303] ( Le2i ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-École Nationale Supérieure d'Arts et Métiers ( ENSAM ), Ben-Gurion University of the Negev ( BGU ), Ben Gurion University, Westfälische Wilhelms-Universität Münster ( WWU ), Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 ( PhLAM ), Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Joseph Louis LAGRANGE ( LAGRANGE ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Observatoire de la Côte d'Azur, Universitat de València ( UV ), Max-Planck-Institut für Sonnensystemforschung ( MPS ), Unite mixte de recherche en droit comparé ( UMRDC ), Université Panthéon-Sorbonne ( UP1 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre universitaire de Cytométrie, Imagerie et Mathématiques ( CIM ), Université de Limoges ( UNILIM ) -CHU Limoges, Institut Cochin ( IC UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Canadian Food Inspection Agency ( CFIA ), Institut Jean-Nicod ( IJN ), Département d'Etudes Cognitives - ENS Paris ( DEC ), École normale supérieure - Paris ( ENS Paris ) -École normale supérieure - Paris ( ENS Paris ) -École des hautes études en sciences sociales ( EHESS ) -Centre National de la Recherche Scientifique ( CNRS ) -Département de Philosophie - ENS Paris, École normale supérieure - Paris ( ENS Paris ), Universidade Estadual Paulista, Laboratoire d'Etudes Sociolinguistiques sur les Contacts de Langues et la Politique Linguistique ( LESCLAP ), Centre d'Immunologie de Marseille - Luminy ( CIML ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Droit Privé et de Sciences Criminelles ( LDPSC ), Aix Marseille Université ( AMU ), Clemson University [USA], University of Zaragoza, Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée ( DAPNIA ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), The University of North Carolina at Chapel Hill, Icahn School of Medicine at Mount Sinai [New York], European Southern Observatory ( ESO ), Centre de Recherches Pétrographiques et Géochimiques ( CRPG ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Centre interuniversitaire de recherche et d'ingenierie des matériaux ( CIRIMAT ), Institut National Polytechnique [Toulouse] ( INP ) -Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique ( CNRS ), Astrophysikalisches Institut Potsdam, University of Las Palmas de Gran Canaria ( ULPGC ), University of Helsinki [Helsinki], Nordic Optical Telescope ( NOT ), Instituto de Astrofisica de Canarias ( IAC ), Royal Institute of Technology [Stockholm] ( KTH ), Institute of Space and Astronautical Science ( ISAS ), Instituto de Astrofísica de Andalucía ( IAA ), Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Instituto Nacional de Engenharia, Tecnologia e Inovacco ( INETI ), INETI, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Laboratoire Microorganismes : Génome et Environnement ( LMGE ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Université d'Auvergne - Clermont-Ferrand I ( UdA ) -Centre National de la Recherche Scientifique ( CNRS ), Observatoire astronomique de Strasbourg ( OAS ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS ), Centre d'études spatiales de la biosphère ( CESBIO ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National d'Etudes Spatiales ( CNES ) -Centre National de la Recherche Scientifique ( CNRS ), Technische Universität Dresden ( TUD ), European Space Astronomy Center ( ESAC ), Géosciences Rennes ( GR ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire des Sciences de l'Univers de Rennes ( OSUR ) -Centre National de la Recherche Scientifique ( CNRS ), Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut national des sciences de l'Univers ( INSU - CNRS ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Grenoble Alpes [Saint Martin d'Hères], Institut Armand Frappier ( INRS-IAF ), Institut National de la Recherche Scientifique [Québec] ( INRS ) -Réseau International des Instituts Pasteur ( RIIP ) -Institut Armand Frappier, Université Montpellier 1 ( UM1 ) -Institut de Recherche pour le Développement ( IRD [Nouvelle-Calédonie] ) -Institut National de la Recherche Agronomique ( INRA ) -Université de Montpellier ( UM ) -Institut national d’études supérieures agronomiques de Montpellier ( Montpellier SupAgro ), Université de Strasbourg ( UNISTRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -EFS, Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), École Centrale de Lyon ( ECL ), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche sur la Fusion par confinement Magnétique ( IRFM ), UNH Department of Physics [Durham], Université de Bourgogne ( UB ) -École Nationale Supérieure d'Arts et Métiers ( ENSAM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Institut Cochin ( UM3 (UMR 8104 / U1016) ), Lille - Economie et Management ( LEM ), Centre National de la Recherche Scientifique ( CNRS ) -Université catholique de Lille ( UCL ) -Université de Lille, Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Centre National de la Recherche Scientifique ( CNRS ) -Université d'Auvergne - Clermont-Ferrand I ( UdA ), Centre National d'Etudes Spatiales (CNES), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Université Nice Sophia Antipolis (UNS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Institut National de la Recherche Agronomique (INRA)-Institut de Recherche pour le Développement (IRD [Nouvelle-Calédonie])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés (LISBP), Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Sigma CLERMONT (Sigma CLERMONT)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-École Centrale de Lyon (ECL), Universidade de Santiago de Compostela [A Coruña, Spain] (USC )-Universidade de Santiago de Compostela [A Coruña, Spain] (USC ), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (CIRAD)-Institut national de la recherche agronomique [Montpellier] (INRA Montpellier)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [APHP], Centro de Astrobiologia, Departamento de Astrofisica (INTA-CSIC), Laboratoire Electronique, Informatique et Image [UMR6303] (Le2i), Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut National Polytechnique [Toulouse] (INP)-Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP)-Centre National d'Etudes Spatiales (CNES)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano [Milano] (UNIMI), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Montpellier 1 (UM1)-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Biologie et pharmacologie des plaquettes sanguines: hémostase, thrombose, transfusion, EFS-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Department of Zoology and Entomology [Pretoria], University of Pretoria [South Africa]-University of Pretoria [South Africa], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Japan Aerospace Exploration Agency [Sagamihara] (JAXA), Instituto Nacional de Engenharia, Tecnologia e Inovacao (INETI), Unité d’Otologie, implants auditifs et chirurgie de la base du crâne [CHU Pitié-Salpêtrière], Service d'Oto-Rhino-Laryngologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS)-Université d'Auvergne - Clermont-Ferrand I (UdA), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Météo-France -Institut de Recherche pour le Développement (IRD)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Météo-France -Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Gaia Collaboration
Subjects: Astrometry, Galaxy: structure, Parallaxes, Proper motions, Space vehicles: instruments, Telescopes, Astronomy and Astrophysics, Space and Planetary Science, [ PHYS ] Physics [physics], instruments [space vehicles], Physics, FOS: Physical sciences, [ SDU.ASTR.IM ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], telescopes, space vehicles: instruments, astrometry, parallaxes, proper motions, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Settore FIS/05 - Astronomia e Astrofisica, Navigations- und Regelungssysteme, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), QC, space vehicles: instruments / Galaxy: structure / astrometry / parallaxes / proper motions / telescopes, QB, structure [Galaxy]
Abstract: Gaia is a cornerstone mission in the science programme of the European Space Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept was changed to a direct-imaging approach. Both the spacecraft and the payload were built by European industry. The involvement of the scientific community focusses on data processing for which the international Gaia Data Processing and Analysis Consortium (DPAC) was selected in 2007. Gaia was launched on 19 December 2013 and arrived at its operating point, the second Lagrange point of the Sun-Earth-Moon system, a few weeks later. The commissioning of the spacecraft and payload was completed on 19 July 2014. The nominal five-year mission started with four weeks of special, ecliptic-pole scanning and subsequently transferred into full-sky scanning mode. We recall the scientific goals of Gaia and give a description of the as-built spacecraft that is currently (mid-2016) being operated to achieve these goals. We pay special attention to the payload module, the performance of which is closely related to the scientific performance of the mission. We provide a summary of the commissioning activities and findings, followed by a description of the routine operational mode. We summarise scientific performance estimates on the basis of in-orbit operations. Several intermediate Gaia data releases are planned and the data can be retrieved from the Gaia Archive, which is available through the Gaia home page at http://www.cosmos.esa.int/gaia., The Gaia Collaboration consists of 625 authors. Accepted by A&A in the Gaia Special Feature

33. Gaia Data Release 1. Summary of the astrometric, photometric, and survey properties

Author: Gaia Collaboration, Brown, A. G. A., Vallenari, A., Prusti, T., Bruijne, J. H. J., Mignard, F., Drimmel, R., Babusiaux, C., Bailer-Jones, C. A. L., Bastian, U., Biermann, M., Evans, D. W., Eyer, L., Jansen, F., Jordi, C., Katz, D., Klioner, S. A., Lammers, U., Lindegren, L., Luri, X., O Mullane, W., Panem, C., Pourbaix, D., Randich, S., Sartoretti, P., Siddiqui, H. I., Soubiran, C., Valette, V., Leeuwen, F., Walton, N. A., Aerts, C., Arenou, F., Cropper, M., Høg, E., Lattanzi, M. G., Grebel, E. K., Holland, A. D., Huc, C., Passot, X., Perryman, M., Bramante, L., Cacciari, C., Castañeda, J., Chaoul, L., Cheek, N., Angeli, F., Fabricius, C., Guerra, R., Hernández, J., Jean-Antoine-Piccolo, A., Masana, E., Messineo, R., Mowlavi, N., Nienartowicz, K., Ordóñez-Blanco, D., Panuzzo, P., Portell, J., Richards, P. J., Riello, M., Seabroke, G. M., Tanga, P., Thévenin, F., Torra, J., Els, S. G., Gracia-Abril, G., Comoretto, G., Garcia-Reinaldos, M., Lock, T., Mercier, E., Altmann, M., Andrae, R., Astraatmadja, T. L., Bellas-Velidis, I., Benson, K., Berthier, J., Blomme, R., Busso, G., Carry, B., Cellino, A., Clementini, G., Cowell, S., Creevey, O., Cuypers, J., Davidson, M., Ridder, J., Torres, A., Delchambre, L., Oro, A., Ducourant, C., Frémat, Y., García-Torres, M., Gosset, E., Halbwachs, J. -L, Hambly, N. C., Harrison, D. L., Hauser, M., Hestroffer, D., Hodgkin, S. T., Huckle, H. E., Hutton, A., Jasniewicz, G., Jordan, S., Kontizas, M., Korn, A. J., Lanzafame, A. C., Manteiga, M., Moitinho, A., Muinonen, K., Osinde, J., Pancino, E., Pauwels, T., Petit, J. -M, Recio-Blanco, A., Robin, A. C., Sarro, L. M., Siopis, C., Smith, M., Smith, K. W., Sozzetti, A., Thuillot, W., Reeven, W., Viala, Y., Abbas, U., Abreu Aramburu, A., Accart, S., Aguado, J. J., Allan, P. M., Allasia, W., Altavilla, G., Álvarez, M. A., Alves, J., Anderson, R. I., Andrei, A. H., Anglada Varela, E., Antiche, E., Antoja, T., Antón, S., Arcay, B., Bach, N., Baker, S. G., Balaguer-Núñez, L., Barache, C., Barata, C., Barbier, A., Barblan, F., Barrado Y Navascués, D., Barros, M., Barstow, M. A., Becciani, U., Bellazzini, M., Bello García, A., Belokurov, V., Bendjoya, P., Berihuete, A., Bianchi, L., Bienaymé, O., Billebaud, F., Blagorodnova, N., Blanco-Cuaresma, S., Boch, T., Bombrun, A., Borrachero, R., Bouquillon, S., Bourda, G., Bouy, H., angela Bragaglia, Breddels, M. A., Brouillet, N., Brüsemeister, T., Bucciarelli, B., Burgess, P., Burgon, R., Burlacu, A., Busonero, D., Buzzi, R., Caffau, E., Cambras, J., Campbell, H., Cancelliere, R., Cantat-Gaudin, T., Carlucci, T., Carrasco, J. M., Castellani, M., Charlot, P., Charnas, J., Chiavassa, A., Clotet, M., Cocozza, G., Collins, R. S., Costigan, G., Crifo, F., Cross, N. J. G., Crosta, M., Crowley, C., Dafonte, C., Damerdji, Y., Dapergolas, A., David, P., David, M., Cat, P., Felice, F., Laverny, P., Luise, F., March, R., Martino, D., Souza, R., Debosscher, J., Del Pozo, E., Delbo, M., Delgado, A., Delgado, H. E., Di Matteo, P., Diakite, S., Distefano, E., Dolding, C., Dos Anjos, S., Drazinos, P., Duran, J., Dzigan, Y., Edvardsson, B., Enke, H., Evans, N. W., Eynard Bontemps, G., Fabre, C., Fabrizio, M., Faigler, S., Falcão, A. J., Farràs Casas, M., Federici, L., Fedorets, G., Fernández-Hernández, J., Fernique, P., Fienga, A., Figueras, F., Filippi, F., Findeisen, K., Fonti, A., Fouesneau, M., Fraile, E., Fraser, M., Fuchs, J., Gai, M., Galleti, S., Galluccio, L., Garabato, D., García-Sedano, F., Garofalo, A., Garralda, N., Gavras, P., Gerssen, J., Geyer, R., Gilmore, G., Girona, S., Giuffrida, G., Gomes, M., González-Marcos, A., González-Núñez, J., González-Vidal, J. J., Granvik, M., Guerrier, A., Guillout, P., Guiraud, J., Gúrpide, A., Gutiérrez-Sánchez, R., Guy, L. P., Haigron, R., Hatzidimitriou, D., Haywood, M., Heiter, U., Helmi, A., Hobbs, D., Hofmann, W., Holl, B., Holland, G., Hunt, J. A. S., Hypki, A., Icardi, V., Irwin, M., Jevardat Fombelle, G., Jofré, P., Jonker, P. G., Jorissen, A., Julbe, F., Karampelas, A., Kochoska, A., Kohley, R., Kolenberg, K., Kontizas, E., Koposov, S. E., Kordopatis, G., Koubsky, P., Krone-Martins, A., Kudryashova, M., Kull, I., Bachchan, R. K., Lacoste-Seris, F., Lanza, A. F., Lavigne, J. -B, Le Poncin-Lafitte, C., Lebreton, Y., Lebzelter, T., Leccia, S., Leclerc, N., Lecoeur-Taibi, I., Lemaitre, V., Lenhardt, H., Leroux, F., Liao, S., Licata, E., Lindstrøm, H. E. P., Lister, T. A., Livanou, E., Lobel, A., Löffler, W., López, M., Lorenz, D., Macdonald, I., Magalhães Fernandes, T., Managau, S., Mann, R. G., Mantelet, G., Marchal, O., Marchant, J. M., Marconi, M., Marinoni, S., Marrese, P. M., Marschalkó, G., Marshall, D. J., Martín-Fleitas, J. M., Martino, M., Mary, N., Matijevič, G., Mazeh, T., Mcmillan, P. J., Messina, S., Michalik, D., Millar, N. R., Miranda, B. M. H., Molina, D., Molinaro, R., Molinaro, M., Molnár, L., Moniez, M., Montegriffo, P., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morgenthaler, S., Morris, D., Mulone, A. F., Muraveva, T., Musella, I., Narbonne, J., Nelemans, G., Nicastro, L., Noval, L., Ordénovic, C., Ordieres-Meré, J., Osborne, P., Pagani, C., Pagano, I., Pailler, F., Palacin, H., Palaversa, L., Parsons, P., Pecoraro, M., Pedrosa, R., Pentikäinen, H., Pichon, B., Piersimoni, A. M., Pineau, F. -X, Plachy, E., Plum, G., Poujoulet, E., Prša, A., Pulone, L., Ragaini, S., Rago, S., Rambaux, N., Ramos-Lerate, M., Ranalli, P., Rauw, G., Read, A., Regibo, S., Reylé, C., Ribeiro, R. A., Rimoldini, L., Ripepi, V., Riva, A., Rixon, G., Roelens, M., Romero-Gómez, M., Rowell, N., Royer, F., Ruiz-Dern, L., Sadowski, G., Sagristà Sellés, T., Sahlmann, J., Salgado, J., Salguero, E., Sarasso, M., Savietto, H., Schultheis, M., Sciacca, E., Segol, M., Segovia, J. C., Segransan, D., Shih, I. -C, Smareglia, R., Smart, R. L., Solano, E., Solitro, F., Sordo, R., Soria Nieto, S., Souchay, J., Spagna, A., Spoto, F., Stampa, U., Steele, I. A., Steidelmüller, H., Stephenson, C. A., Stoev, H., Suess, F. F., Süveges, M., Surdej, J., Szabados, L., Szegedi-Elek, E., Tapiador, D., Taris, F., Tauran, G., Taylor, M. B., Teixeira, R., Terrett, D., Tingley, B., Trager, S. C., Turon, C., Ulla, A., Utrilla, E., Valentini, G., Elteren, A., Hemelryck, E., Leeuwen, M., Varadi, M., Vecchiato, A., Veljanoski, J., Via, T., Vicente, D., Vogt, S., Voss, H., Votruba, V., Voutsinas, S., Walmsley, G., Weiler, M., Weingrill, K., Wevers, T., Wyrzykowski, Ł., Yoldas, A., Žerjal, M., Zucker, S., Zurbach, C., Zwitter, T., Alecu, A., Allen, M., Allende Prieto, C., Amorim, A., Anglada-Escudé, G., Arsenijevic, V., Azaz, S., Balm, P., Beck, M., Bernstein, H. -H, Bigot, L., Bijaoui, A., Blasco, C., Bonfigli, M., Bono, G., Boudreault, S., Bressan, A., Brown, S., Brunet, P. -M, Bunclark, P., Buonanno, R., Butkevich, A. G., Carret, C., Carrion, C., Chemin, L., Chéreau, F., Corcione, L., Darmigny, E., Boer, K. S., Teodoro, P., Zeeuw, P. T., Delle Luche, C., Domingues, C. D., Dubath, P., Fodor, F., Frézouls, B., Fries, A., Fustes, D., Fyfe, D., Gallardo, E., Gallegos, J., Gardiol, D., Gebran, M., Gomboc, A., Gómez, A., Grux, E., Gueguen, A., Heyrovsky, A., Hoar, J., Iannicola, G., Isasi Parache, Y., Janotto, A. -M, Joliet, E., Jonckheere, A., Keil, R., Kim, D. -W, Klagyivik, P., Klar, J., Knude, J., Kochukhov, O., Kolka, I., Kos, J., Kutka, A., Lainey, V., Lebouquin, D., Liu, C., Loreggia, D., Makarov, V. V., Marseille, M. G., Martayan, C., Martinez-Rubi, O., Massart, B., Meynadier, F., Mignot, S., Munari, U., Nguyen, A. -T, Nordlander, T., Ocvirk, P., O Flaherty, K. S., Olias Sanz, A., Ortiz, P., Osorio, J., Oszkiewicz, D., Ouzounis, A., Palmer, M., Park, P., Pasquato, E., Peltzer, C., Peralta, J., Péturaud, F., Pieniluoma, T., Pigozzi, E., Poels, J., Prat, G., Prod Homme, T., Raison, F., Rebordao, J. M., Risquez, D., Rocca-Volmerange, B., Rosen, S., Ruiz-Fuertes, M. I., Russo, F., Sembay, S., Serraller Vizcaino, I., Short, A., Siebert, A., Silva, H., Sinachopoulos, D., Slezak, E., Soffel, M., Sosnowska, D., Straižys, V., Ter Linden, M., Terrell, D., Theil, S., Tiede, C., Troisi, L., Tsalmantza, P., Tur, D., Vaccari, M., Vachier, F., Valles, P., Hamme, W., Veltz, L., Virtanen, J., Wallut, J. -M, Wichmann, R., Wilkinson, M. I., Ziaeepour, H., Zschocke, S., European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Zentrum für astronomie, Universität Heidelberg [Heidelberg], Department of Clinical Medicine, University of Bergen (UiB), Department of nuclear medicine, Haukeland University Hospital, University of Bergen (UiB)-University of Bergen (UiB), Centre for Research in Earth and Space Science [Toronto] (CRESS), York University [Toronto], Geneva Observatory, University of Geneva [Switzerland], University of Illinois at Urbana Champaign (UIUC), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System-University of Illinois System, Agence Spatiale Européenne (ESA), Human Cancer Genetics Program, Comprehensive Cancer Center-College of Medicine and Public Health [Colombus], M2A 2016, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES), Institute of Astronomy [Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), University of California [San Diego] (UC San Diego), University of California, Department of Biomedical Sciences, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Nelson Mandela Metropolitan University [Port Elizabeth, South Africa], Laboratorio de Inmunologıa y Virologıa, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolas de los Garza, Solvay (France), Joseph Louis LAGRANGE (LAGRANGE), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA), European Space Astronomy Centre (ESAC), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Systèmes de Référence Temps Espace (SYRTE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Royal Observatory of Belgium [Brussels] (ROB), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université de Picardie Jules Verne (UPJV), University of Edinburgh, Laboratório de Ictiologia e Pesca, Universidade Federal de Rondônia [Brésil] (UNIR), Institute of Astronomy [Cambridge], University of Cambridge [UK] (CAM), Laboratoire Univers et Particules de Montpellier (LUPM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Department of Pathology and Cell Biology, Columbia University [New York], SIM/IDL Faculdade de Ciências da Universidade de Lisboa (FCUL), University of Lisboa, Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Florida State University [Tallahassee] (FSU), Department of Computer Science, University of York [York, UK], AUTRES, Universidad de Murcia, EURIX (.), INTA (INTA), INTA, South Iceland Research Centre, University of Iceland [Reykjavik], CESAM, Universidade de Aveiro, United States Geological Survey [Reston] (USGS), Récepteurs et Canaux Ioniques Membranaires (RCIM), Université d'Angers (UA)-Institut National de la Recherche Agronomique (INRA), Department of Medicine, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Universitat de Barcelona (UB), Institute of Environmental Assessment and Water Research (IDAEA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Thales Services, THALES, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Department of Physics and Astronomy [Leicester], University of Leicester, Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Observatoire Astronomique de l'Université de Genève (ObsGE), Université de Genève (UNIGE), Université Grenoble Alpes - UFR Langage, lettres et arts du spectacle, information et communication - Dpt Lettres et arts du spectacle (UGA UFR LLASIC LAS), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), FORMATION STELLAIRE 2016, School of Physical Sciences [Milton Keynes], Faculty of Science, Technology, Engineering and Mathematics [Milton Keynes], The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), CICEnergigune, Observatoire de Haute-Provence (OHP), Institut Pythéas (OSU PYTHEAS), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut de Recherche pour le Développement (IRD), Centre d'étude spatiale des rayonnements (CESR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Queen Elizabeth Hospital, Queens Elizabeth Hospital [Birmingham], International Parkinson's Centre of Excellence [Londres], King's College Hospital (KCH)-King‘s College London, Hospital Israelita Albert Einstein, Department of Computing, Electronics and Mechatronics, Universidad de las Américas [Puebla] (UDLAP), Activité Physique, Muscle, Santé (EA4488), Université de Lille, Droit et Santé, Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), INAF - Osservatorio Astronomico di Bologna (OABO), Istituto Nazionale di Astrofisica (INAF), Géoazur (GEOAZUR 7329), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Università degli Studi di Roma 'La Sapienza' [Rome], Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Astrometry, INAF - Osservatorio Astrofisico di Torino (OATo), Istituto Nazionale di Astrofisica (INAF)-Istituto Nazionale di Astrofisica (INAF), Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA), Federal University of Para - Universidade Federal do Para [Belem - Brésil], Department of Mechanical, Informatics and Aerospace Engineering [León], Universidad de León [León], Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Sciences Pour l'Oenologie (SPO), Université Montpellier 1 (UM1)-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Department of Physics [Athens], National and Kapodistrian University of Athens (NKUA), Departament Llenguatges i Sistemes Informatics, Universitat Politècnica de Catalunya [Barcelona] (UPC), Heckscher-Klinikum, SRON Netherlands Institute for Space Research (SRON), Department of Astrophysics [Nijmegen], Institute for Mathematics, Astrophysics and Particle Physics (IMAPP), Radboud university [Nijmegen]-Radboud university [Nijmegen], Institut d'Astronomie et d'Astrophysique, Université libre de Bruxelles (ULB), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Biologie et pharmacologie des plaquettes sanguines: hémostase, thrombose, transfusion, EFS-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Virulence bactérienne et maladies infectieuses (VBMI), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA), Institut de Chimie de Clermont-Ferrand (ICCF), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS), Chinese Academy of Sciences [Beijing] (CAS), Atmel Corporation (ATMEL), ATMEL, Probabilités, statistique, physique mathématique (PSPM), Institut Camille Jordan [Villeurbanne] (ICJ), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Astrophysics Research Institute [Liverpool] (ARI), Liverpool John Moores University (LJMU), Institut Non Linéaire de Nice Sophia-Antipolis (INLN), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Centre for Integrative Physiology, Mammal Research Institute, Department of Zoology and Entomology [Pretoria], University of Pretoria [South Africa]-University of Pretoria [South Africa], UCT/MRC Receptor Biology Unit, University of Cape Town, Physics and Materials Science Research Unit, University of Luxembourg, University of Luxembourg [Luxembourg], Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Istituto Nazionale di Astrofisica (Istituto Nazionale di Astrofisica), Istituto Nazionale di Fisica Nucleare (INFN), INAF - Osservatorio Astronomico di Trieste (OAT), Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Departamento de Microbiología y Parasitología [Lugo, Spain], Laboratorio de Referencia de E. coli [Lugo, Spain] (LREC), Universidade de Santiago de Compostela [Spain] (USC )-Universidade de Santiago de Compostela [Spain] (USC ), CERFACS [Toulouse], Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), RedZinc Services Ltd.[Dublin], Laboratoire de Physico -& Toxico Chimie des systèmes naturels (LPTC), Université Sciences et Technologies - Bordeaux 1-Centre National de la Recherche Scientifique (CNRS), GIRM, Instituto Politécnico de Leiria, Service de la Radio-Oncologie [Saint-Herblain], Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER-UNICANCER, Service de Neurologie [Hôpitaux Civils de Colmar], Hôpitaux Civils Colmar, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Institute of Hepatology, Birkbeck College [University of London]-Foundation for Liver Research, Département Réseaux, Information, Multimédia (RIM-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre G2I, Department of Biochemical and Chemical Engineering, Technische Universität Dortmund [Dortmund] (TU), Équipes de Recherches Interlangues : Mémoires, Identités, Territoires (ERIMIT), Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université Paris 1 Panthéon-Sorbonne - UFR d'Économie (UP1 UFR02), Université Paris 1 Panthéon-Sorbonne (UP1), Department of Paleobiology [Washington], Smithsonian Institution, Capital Normal University [Beijing], Departamento de Astrofisica [Madrid], Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Spanish Virtual Observatory - Observatorio Virtual Español (SVO), Spanish Virtual Observatory - Observatorio Virtual Español, Department of Computer Science [Verona] (UNIVR | DI), University of Verona (UNIVR), Geophysical Laboratory [Carnegie Institution], Carnegie Institution for Science [Washington], Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), University of Paderborn, Karl-Franzens-Universität Graz, HE Space Operations BV for ESA/ESTEC, Institute of Hydrology, University of Freiburg [Freiburg], Ben-Gurion University of the Negev (BGU), Department of Computer Science [Beer-Sheva], CENTRA-SIM, IDL-Faculdade de Ciencias da Universidade de Lisboa, Westfälische Wilhelms-Universität Münster (WWU), Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM), Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Laboratori de Bromatologia i Toxicologia, Facultat de Farmàcia, Universitat de València (UV), Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, Manomet Center for Conservation Sciences, Matière et Systèmes Complexes (MSC (UMR_7057)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre universitaire de Cytométrie, Imagerie et Mathématiques (CIM), Université de Limoges (UNILIM)-CHU Limoges, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Canadian Food Inspection Agency (CFIA), Institut Jean-Nicod (IJN), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Département de Philosophie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Universidade Estadual Paulista Júlio de Mesquita Filho [São José do Rio Preto] (UNESP), Centre d'Etudes des Relations et Contacts Linguistiques et Littéraires - UR UPJV 4283 (CERCLL), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Droit Privé et de Sciences Criminelles (LDPSC), Aix Marseille Université (AMU), Department of Physics and Astronomy [Clemson], Clemson University, IFP Energies nouvelles (IFPEN), Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Lineberger Comprehensive Cancer Center (UNC Lineberger), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC)-University of North Carolina System (UNC), Uppsala University, Center for Ultrafast Optical Science, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Seaver Autism Center for Research and Treatment, Department of Psychiatry, European Southern Observatory (ESO), Centre de Recherches Pétrographiques et Géochimiques (CRPG), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Leibniz Institute for Astrophysics Potsdam (AIP), Innovalia Association, University of Las Palmas de Gran Canaria (ULPGC), Nordic Optical Telescope (NOT), Instituto de Astrofisica de Canarias (IAC), Department of Physics [Helsinki], Falculty of Science [Helsinki], University of Helsinki-University of Helsinki, Royal Institute of Technology [Stockholm] (KTH ), Instituto de Astrofísica de Andalucía (IAA), Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency [Sagamihara] (JAXA), Instituto Nacional de Engenharia, Tecnologia e Inovacco (INETI), Service d'Otologie, Implants auditifs et Chirurgie de la base du crâne [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Réhabilitation Chirurgicale mini-Invasive et Robotisée de l'Audition, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidade de Coimbra [Coimbra], Sonoita Research Observatory, Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS)-Université d'Auvergne - Clermont-Ferrand I (UdA), Institute of Physical Geodesy, sans affiliation, Observatoire astronomique de Strasbourg (OAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Centre d'études spatiales de la biosphère (CESBIO), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Lohrmann Observatory, Technische Universität Dresden = Dresden University of Technology (TU Dresden), PSL Research University (PSL)-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), University of Bergen (UIB), University of Bergen (UIB)-University of Bergen (UIB), Ecologie, Evolution, Symbiose (EES), Ecologie et biologie des interactions (EBI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Royal Observatory of Belgium [Brussels], Università di Bologna [Bologna] (UNIBO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Universidade Federal de Rondônia, Institute of Astronomy, Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Laboratoire Récepteurs et Canaux Ioniques Membranaires (RCIM), IDAEA-CSIC, Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA), Université Grenoble Alpes (UGA), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), The Open University [Milton Keynes] (OU), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Biologie Intégrative des Populations, École pratique des hautes études (EPHE)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD [Nouvelle-Calédonie])-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), National and Kapodistrian University of Athens = University of Athens (NKUA | UoA), Université Libre de Bruxelles [Bruxelles] (ULB), Biologie et pharmacologie des plaquettes sanguines: hémostase, thrombose, transfusion (http://www.u949.inserm.fr/), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Sigma CLERMONT (Sigma CLERMONT), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), University of Pretoria [South Africa], National Institute for Nuclear Physics (INFN), Institut de Cancérologie de l'Ouest- ICO Gauducheau, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique (CNRS), Université Panthéon-Sorbonne - UFR d'Économie (UP1 UFR02), Université Panthéon-Sorbonne (UP1), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Università degli Studi di Verona, Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Philosophie - ENS Paris, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-École des hautes études en sciences sociales (EHESS)-Département d'Etudes Cognitives - ENS Paris (DEC), Laboratoire d'Etudes Sociolinguistiques sur les Contacts de Langues et la Politique Linguistique (LESCLAP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Lineberger Comprehensive Cancer Center, Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Technische Universität Dresden (TUD), Brown, A.G.A., Vallenari, A., Prusti, T., De Bruijne, J.H.J., Mignard, F., Drimmel, R., Babusiaux, C., Bailer-Jones, C.A.L., Bastian, U., Biermann, M., Evans, D.W., Eyer, L., Jansen, F., Jordi, C., Katz, D., Klioner, S.A., Lammers, U., Lindegren, L., Luri, X., O'Mullane, W., Panem, C., Pourbaix, D., Randich, S., Sartoretti, P., Siddiqui, H.I., Soubiran, C., Valette, V., Van Leeuwen, F., Walton, N.A., Aerts, C., Arenou, F., Cropper, M., Høg, E., Lattanzi, M.G., Grebel, E.K., Holland, A.D., Huc, C., Passot, X., Perryman, M., Bramante, L., Cacciari, C., Castañeda, J., Chaoul, L., Cheek, N., De Angeli, F., Fabricius, C., Guerra, R., Hernández, J., Jean-Antoine-Piccolo, A., Masana, E., Messineo, R., Mowlavi, N., Nienartowicz, K., Ordóñez-Blanco, D., Panuzzo, P., Portell, J., Richards, P.J., Riello, M., Seabroke, G.M., Tanga, P., Thévenin, F., Torra, J., Els, S.G., Gracia-Abril, G., Comoretto, G., Garcia-Reinaldos, M., Lock, T., Mercier, E., Altmann, M., Andrae, R., Astraatmadja, T.L., Bellas-Velidis, I., Benson, K., Berthier, J., Blomme, R., Busso, G., Carry, B., Cellino, A., Clementini, G., Cowell, S., Creevey, O., Cuypers, J., Davidson, M., De Ridder, J., De Torres, A., Delchambre, L., Dell'Oro, A., Ducourant, C., Frémat, Y., García-Torres, M., Gosset, E., Halbwachs, J.-L., Hambly, N.C., Harrison, D.L., Hauser, M., Hestroffer, D., Hodgkin, S.T., Huckle, H.E., Hutton, A., Jasniewicz, G., Jordan, S., Kontizas, M., Korn, A.J., Lanzafame, A.C., Manteiga, M., Moitinho, A., Muinonen, K., Osinde, J., Pancino, E., Pauwels, T., Petit, J.-M., Recio-Blanco, A., Robin, A.C., Sarro, L.M., Siopis, C., Smith, M., Smith, K.W., Sozzetti, A., Thuillot, W., Van Reeven, W., Viala, Y., Abbas, U., Abreu Aramburu, A., Accart, S., Aguado, J.J., Allan, P.M., Allasia, W., Altavilla, G., Álvarez, M.A., Alves, J., Anderson, R.I., Andrei, A.H., Anglada Varela, E., Antiche, E., Antoja, T., Antón, S., Arcay, B., Bach, N., Baker, S.G., Balaguer-Núñez, L., Barache, C., Barata, C., Barbier, A., Barblan, F., Barrado Y Navascués, D., Barros, M., Barstow, M.A., Becciani, U., Bellazzini, M., Bello García, A., Belokurov, V., Bendjoya, P., Berihuete, A., Bianchi, L., Bienaymé, O., Billebaud, F., Blagorodnova, N., Blanco-Cuaresma, S., Boch, T., Bombrun, A., Borrachero, R., Bouquillon, S., Bourda, G., Bouy, H., Bragaglia, A., Breddels, M.A., Brouillet, N., Brüsemeister, T., Bucciarelli, B., Burgess, P., Burgon, R., Burlacu, A., Busonero, D., Buzzi, R., Caffau, E., Cambras, J., Campbell, H., Cancelliere, R., Cantat-Gaudin, T., Carlucci, T., Carrasco, J.M., Castellani, M., Charlot, P., Charnas, J., Chiavassa, A., Clotet, M., Cocozza, G., Collins, R.S., Costigan, G., Crifo, F., Cross, N.J.G., Crosta, M., Crowley, C., Dafonte, C., Damerdji, Y., Dapergolas, A., David, P., David, M., De Cat, P., De Felice, F., De Laverny, P., De Luise, F., De March, R., De Martino, D., De Souza, R., Debosscher, J., Del Pozo, E., Delbo, M., Delgado, A., Delgado, H.E., Di Matteo, P., Diakite, S., Distefano, E., Dolding, C., Dos Anjos, S., Drazinos, P., Duran, J., Dzigan, Y., Edvardsson, B., Enke, H., Evans, N.W., Eynard Bontemps, G., Fabre, C., Fabrizio, M., Faigler, S., Falcão, A.J., Farràs Casas, M., Federici, L., Fedorets, G., Fernández-Hernández, J., Fernique, P., Fienga, A., Figueras, F., Filippi, F., Findeisen, K., Fonti, A., Fouesneau, M., Fraile, E., Fraser, M., Fuchs, J., Gai, M., Galleti, S., Galluccio, L., Garabato, D., García-Sedano, F., Garofalo, A., Garralda, N., Gavras, P., Gerssen, J., Geyer, R., Gilmore, G., Girona, S., Giuffrida, G., Gomes, M., González-Marcos, A., González-Núñez, J., González-Vidal, J.J., Granvik, M., Guerrier, A., Guillout, P., Guiraud, J., Gúrpide, A., Gutiérrez-Sánchez, R., Guy, L.P., Haigron, R., Hatzidimitriou, D., Haywood, M., Heiter, U., Helmi, A., Hobbs, D., Hofmann, W., Holl, B., Holland, G., Hunt, J.A.S., Hypki, A., Icardi, V., Irwin, M., Jevardat De Fombelle, G., Jofré, P., Jonker, P.G., Jorissen, A., Julbe, F., Karampelas, A., Kochoska, A., Kohley, R., Kolenberg, K., Kontizas, E., Koposov, S.E., Kordopatis, G., Koubsky, P., Krone-Martins, A., Kudryashova, M., Kull, I., Bachchan, R.K., Lacoste-Seris, F., Lanza, A.F., Lavigne, J.-B., Le Poncin-Lafitte, C., Lebreton, Y., Lebzelter, T., Leccia, S., Leclerc, N., Lecoeur-Taibi, I., Lemaitre, V., Lenhardt, H., Leroux, F., Liao, S., Licata, E., Lindstrøm, H.E.P., Lister, T.A., Livanou, E., Lobel, A., Löffler, W., López, M., Lorenz, D., MacDonald, I., Magalhães Fernandes, T., Managau, S., Mann, R.G., Mantelet, G., Marchal, O., Marchant, J.M., Marconi, M., Marinoni, S., Marrese, P.M., Marschalkó, G., Marshall, D.J., Martín-Fleitas, J.M., Martino, M., Mary, N., Matijevič, G., Mazeh, T., McMillan, P.J., Messina, S., Michalik, D., Millar, N.R., Miranda, B.M.H., Molina, D., Molinaro, R., Molinaro, M., Molnár, L., Moniez, M., Montegriffo, P., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morgenthaler, S., Morris, D., Mulone, A.F., Muraveva, T., Musella, I., Narbonne, J., Nelemans, G., Nicastro, L., Noval, L., Ordénovic, C., Ordieres-Meré, J., Osborne, P., Pagani, C., Pagano, I., Pailler, F., Palacin, H., Palaversa, L., Parsons, P., Pecoraro, M., Pedrosa, R., Pentikäinen, H., Pichon, B., Piersimoni, A.M., Pineau, F.-X., Plachy, E., Plum, G., Poujoulet, E., Prša, A., Pulone, L., Ragaini, S., Rago, S., Rambaux, N., Ramos-Lerate, M., Ranalli, P., Rauw, G., Read, A., Regibo, S., Reylé, C., Ribeiro, R.A., Rimoldini, L., Ripepi, V., Riva, A., Rixon, G., Roelens, M., Romero-Gómez, M., Rowell, N., Royer, F., Ruiz-Dern, L., Sadowski, G., Sagristà Sellés, T., Sahlmann, J., Salgado, J., Salguero, E., Sarasso, M., Savietto, H., Schultheis, M., Sciacca, E., Segol, M., Segovia, J.C., Segransan, D., Shih, I.-C., Smareglia, R., Smart, R.L., Solano, E., Solitro, F., Sordo, R., Soria Nieto, S., Souchay, J., Spagna, A., Spoto, F., Stampa, U., Steele, I.A., Steidelmüller, H., Stephenson, C.A., Stoev, H., Suess, F.F., Süveges, M., Surdej, J., Szabados, L., Szegedi-Elek, E., Tapiador, D., Taris, F., Tauran, G., Taylor, M.B., Teixeira, R., Terrett, D., Tingley, B., Trager, S.C., Turon, C., Ulla, A., Utrilla, E., Valentini, G., Van Elteren, A., Van Hemelryck, E., Van Leeuwen, M., Varadi, M., Vecchiato, A., Veljanoski, J., Via, T., Vicente, D., Vogt, S., Voss, H., Votruba, V., Voutsinas, S., Walmsley, G., Weiler, M., Weingrill, K., Wevers, T., Wyrzykowski, Å ., Yoldas, A., Žerjal, M., Zucker, S., Zurbach, C., Zwitter, T., Alecu, A., Allen, M., Allende Prieto, C., Amorim, A., Anglada-Escudé, G., Arsenijevic, V., Azaz, S., Balm, P., Beck, M., Bernstein, H.-H., Bigot, L., Bijaoui, A., Blasco, C., Bonfigli, M., Bono, G., Boudreault, S., Bressan, A., Brown, S., Brunet, P.-M., Bunclark, P., Buonanno, R., Butkevich, A.G., Carret, C., Carrion, C., Chemin, L., Chéreau, F., Corcione, L., Darmigny, E., De Boer, K.S., De Teodoro, P., De Zeeuw, P.T., Delle Luche, C., Domingues, C.D., Dubath, P., Fodor, F., Frézouls, B., Fries, A., Fustes, D., Fyfe, D., Gallardo, E., Gallegos, J., Gardiol, D., Gebran, M., Gomboc, A., Gómez, A., Grux, E., Gueguen, A., Heyrovsky, A., Hoar, J., Iannicola, G., Isasi Parache, Y., Janotto, A.-M., Joliet, E., Jonckheere, A., Keil, R., Kim, D.-W., Klagyivik, P., Klar, J., Knude, J., Kochukhov, O., Kolka, I., Kos, J., Kutka, A., Lainey, V., LeBouquin, D., Liu, C., Loreggia, D., Makarov, V.V., Marseille, M.G., Martayan, C., Martinez-Rubi, O., Massart, B., Meynadier, F., Mignot, S., Munari, U., Nguyen, A.-T., Nordlander, T., Ocvirk, P., O'Flaherty, K.S., Olias Sanz, A., Ortiz, P., Osorio, J., Oszkiewicz, D., Ouzounis, A., Palmer, M., Park, P., Pasquato, E., Peltzer, C., Peralta, J., Péturaud, F., Pieniluoma, T., Pigozzi, E., Poels, J., Prat, G., Prod'homme, T., Raison, F., Rebordao, J.M., Risquez, D., Rocca-Volmerange, B., Rosen, S., Ruiz-Fuertes, M.I., Russo, F., Sembay, S., Serraller Vizcaino, I., Short, A., Siebert, A., Silva, H., Sinachopoulos, D., Slezak, E., Soffel, M., Sosnowska, D., Straižys, V., Ter Linden, M., Terrell, D., Theil, S., Tiede, C., Troisi, L., Tsalmantza, P., Tur, D., Vaccari, M., Vachier, F., Valles, P., Van Hamme, W., Veltz, L., Virtanen, J., Wallut, J.-M., Wichmann, R., Wilkinson, M.I., Ziaeepour, H., Zschocke, S., Astronomy, ITA, Equipe EES, Departments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California, San Diego, La Jolla, CA 92093-0841, USA, Centre National d'Etudes Spatiales (CNES), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire Lagrange - Observatoire de la Côte d'Azur, Université Nice Sophia Antipolis (UNS), Astrophysique Interprétation Modélisation (AIM - UMR 7158 - UMR E 9005), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS), Florida State University, Mount Sinai School of Medicine, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP)-Centre National de la Recherche Scientifique (CNRS), King's College Hospital-King‘s College London, Géoazur (GEOAZUR), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Institut National de la Recherche Agronomique (INRA)-Institut de Recherche pour le Développement (IRD [Nouvelle-Calédonie])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Department of Physics (Athens), Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés (LISBP), Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Virulence bactérienne et maladies infectieuses, Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Sigma CLERMONT (Sigma CLERMONT)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-École Centrale de Lyon (ECL), Université de Lyon, Universidade de Santiago de Compostela [A Coruña, Spain] (USC )-Universidade de Santiago de Compostela [A Coruña, Spain] (USC ), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [APHP], Institut Mines-Télécom [Paris]-Institut Mines-Télécom [Paris]-Centre G2I, Centro de Astrobiologia, Departamento de Astrofisica (INTA-CSIC), Konkoly Observatory, Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences [Budapest], Laboratoire Matière et Systèmes Complexes (MSC (UMR 7057)), Universidade Estadual Paulista, Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Clemson University [USA], The University of North Carolina at Chapel Hill, Icahn School of Medicine at Mount Sinai [New York], Institut National Polytechnique [Toulouse] (INP)-Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Helsinki [Helsinki], Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP)-Centre National d'Etudes Spatiales (CNES)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 1 (UM1), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD [Nouvelle-Calédonie])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), European Space Research and Technology Centre ( ESTEC ), European Space Agency ( ESA ), University of Bergen ( UIB ), Centre for Research in Earth and Space Science [Toronto] ( CRESS ), University of Illinois at Urbana Champaign ( UIUC ), Agence Spatiale Européenne ( ESA ), Laboratoire d'Astrophysique de Bordeaux [Pessac] ( LAB ), Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Ecologie et biologie des interactions ( EBI ), Université de Poitiers-Centre National de la Recherche Scientifique ( CNRS ) -Université de Poitiers-Centre National de la Recherche Scientifique ( CNRS ), Katholieke Universiteit Leuven ( KU Leuven ), Centre National d'Etudes Spatiales ( CNES ), University of Modena & Reggio-Emilia, Galaxies, Etoiles, Physique, Instrumentation ( GEPI ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), European Space Astronomy Center ( ESAC ), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires ( EA 2992 ), Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Systèmes de Référence Temps Espace ( SYRTE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Centre National de la Recherche Scientifique ( CNRS ), Mullard Space Science Laboratory ( MSSL ), University College of London [London] ( UCL ), Institut de Mécanique Céleste et de Calcul des Ephémérides ( IMCCE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Università di Bologna [Bologna] ( UNIBO ), Institut d'astrophysique spatiale ( IAS ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Astrophysique Interactions Multi-échelles ( AIM - UMR 7158 - UMR E 9005 ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Paris Diderot - Paris 7 ( UPD7 ), Université de Picardie Jules Verne ( UPJV ), University of Cambridge [UK] ( CAM ), Laboratoire Univers et Particules de Montpellier ( LUPM ), Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), SIM/IDL Faculdade de Ciências da Universidade de Lisboa ( FCUL ), Lisboa university, Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) ( UTINAM ), Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut national des sciences de l'Univers ( INSU - CNRS ), INTA ( INTA ), United States Geological Survey [Reston] ( USGS ), Laboratoire Récepteurs et Canaux Ioniques Membranaires ( RCIM ), Université d'Angers ( UA ) -Institut National de la Recherche Agronomique ( INRA ), Universitat de Barcelona ( UB ), Institut de Planétologie et d'Astrophysique de Grenoble ( IPAG ), Observatoire des Sciences de l'Univers de Grenoble ( OSUG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ), Université Côte d'Azur ( UCA ), Observatoire aquitain des sciences de l'univers ( OASU ), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Observatoire Astronomique de l'Université de Genève ( ObsGE ), Université de Genève ( UNIGE ), Université Grenoble Alpes - UFR Langage, lettres et arts du spectacle, information et communication - Dpt Lettres et arts du spectacle ( UGA UFR LLASIC LAS ), Université Grenoble Alpes ( UGA ), Institut de Chimie Moléculaire de Reims - UMR 7312 ( ICMR ), Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ) -Centre National de la Recherche Scientifique ( CNRS ) -SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ) -Université de Reims Champagne-Ardenne ( URCA ) -Université de Picardie Jules Verne ( UPJV ) -Université de Reims Champagne-Ardenne ( URCA ) -Centre National de la Recherche Scientifique ( CNRS ), Centro de Astrobiologia [Madrid] ( CAB ), Instituto Nacional de Técnica Aeroespacial ( INTA ) -Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), The Open University [Milton Keynes] ( OU ), Centre de Recherches Anglophones ( CREA (EA 370) ), Université Paris Nanterre ( UPN ), Observatoire de Haute-Provence ( OHP ), Institut Pythéas ( OSU PYTHEAS ), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture ( IRSTEA ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture ( IRSTEA ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Centre d'étude spatiale des rayonnements ( CESR ), Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Universidad de las Américas [Puebla] ( UDLAP ), Activité Physique, Muscle, Santé ( EA4488 ), Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies ( SISSA / ISAS ), INAF - Osservatorio Astronomico di Bologna ( OABO ), Istituto Nazionale di Astrofisica ( INAF ), Géoazur ( GEOAZUR ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de recherches sur la catalyse et l'environnement de Lyon ( IRCELYON ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Institut Armand Frappier ( INRS-IAF ), Institut National de la Recherche Scientifique [Québec] ( INRS ) -Réseau International des Instituts Pasteur ( RIIP ) -Institut Armand Frappier, École pratique des hautes études ( EPHE ) -Centre National de la Recherche Scientifique ( CNRS ), INAF - Osservatorio Astrofisico di Torino ( OATo ), Istituto Nazionale di Astrofisica ( INAF ) -Istituto Nazionale di Astrofisica ( INAF ), Institut de Physique et Chimie des Matériaux de Strasbourg ( IPCMS ), Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ) -Matériaux et nanosciences d'Alsace, Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Réseau nanophotonique et optique, Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ), University of León, Observatoire astronomique de Strasbourg ( ObAS ), Université de Strasbourg ( UNISTRA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Sciences Pour l'Oenologie ( SPO ), Université Montpellier 1 ( UM1 ) -Institut de Recherche pour le Développement ( IRD [Nouvelle-Calédonie] ) -Institut National de la Recherche Agronomique ( INRA ) -Université de Montpellier ( UM ) -Institut national d’études supérieures agronomiques de Montpellier ( Montpellier SupAgro ), Universitat Politècnica de Catalunya [Barcelona] ( UPC ), Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés ( LISBP ), Institut National de la Recherche Agronomique ( INRA ) -Institut National des Sciences Appliquées - Toulouse ( INSA Toulouse ), Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Centre National de la Recherche Scientifique ( CNRS ), SRON Netherlands Institute for Space Research ( SRON ), Institute for Mathematics, Astrophysics and Particle Physics ( IMAPP ), Université Libre de Bruxelles [Bruxelles] ( ULB ), The Institute of Environmental Medicine [Stockholm] ( IMM ), Biologie et pharmacologie des plaquettes sanguines: hémostase, thrombose, transfusion ( http://www.u949.inserm.fr/ ), Université de Strasbourg ( UNISTRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -EFS, Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Physique de Rennes ( IPR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de chimie et procédés pour l'énergie, l'environnement et la santé ( ICPEES ), Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Chimie de Clermont-Ferrand ( ICCF ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Sigma CLERMONT ( Sigma CLERMONT ) -Centre National de la Recherche Scientifique ( CNRS ), Chinese Academy of Sciences [Beijing] ( CAS ), Atmel Corporation ( ATMEL ), Institut Camille Jordan [Villeurbanne] ( ICJ ), École Centrale de Lyon ( ECL ), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Centre National de la Recherche Scientifique ( CNRS ), Astrophysics Research Institute [Liverpool] ( ARI ), Liverpool John Moores University ( LJMU ), Institut Non Linéaire de Nice Sophia-Antipolis ( INLN ), Matériaux, ingénierie et science [Villeurbanne] ( MATEIS ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ) -Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ), Institut de Recherche sur la Fusion par confinement Magnétique ( IRFM ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Istituto Nazionale di Astrofisica ( Istituto Nazionale di Astrofisica ), National Institute for Nuclear Physics ( INFN ), INAF - Osservatorio Astronomico di Trieste ( OAT ), Laboratoire SUBATECH Nantes ( SUBATECH ), Mines Nantes ( Mines Nantes ) -Université de Nantes ( UN ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratorio de Referencia de E. coli [Lugo, Spain] ( LREC ), Universidade de Santiago de Compostela [A Coruña, Spain] ( USC ) -Universidade de Santiago de Compostela [A Coruña, Spain] ( USC ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physico -& Toxico Chimie des systèmes naturels ( LPTC ), Université Sciences et Technologies - Bordeaux 1-Centre National de la Recherche Scientifique ( CNRS ), Botanique et Modélisation de l'Architecture des Plantes et des Végétations ( UMR AMAP ), Centre de Coopération Internationale en Recherche Agronomique pour le Développement ( CIRAD ) -Institut national de la recherche agronomique [Montpellier] ( INRA Montpellier ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD [France-Sud] ), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute ( ICM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique ( CNRS ), Département Réseaux, Information, Multimédia ( RIM-ENSMSE ), École des Mines de Saint-Étienne ( Mines Saint-Étienne MSE ), Technische Universität Dortmund [Dortmund] ( TU ), Équipes de Recherches Interlangues : Mémoires, Identités, Territoires ( ERIMIT ), Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ), Université Panthéon-Sorbonne - UFR d'Économie ( UP1 UFR02 ), Université Panthéon-Sorbonne ( UP1 ), Centro de Astrobiologia, Departamento de Astrofisica ( INTA-CSIC ), Centro de Astrobiología, Spanish Virtual Observatory - Observatorio Virtual Español ( SVO ), Physikalisch Technische Bundesanstalt ( PTB ), Ben Gurion University, Ben-Gurion University of the Negev ( BGU ), Westfälische Wilhelms-Universität Münster ( WWU ), Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 ( PhLAM ), Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Joseph Louis LAGRANGE ( LAGRANGE ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Observatoire de la Côte d'Azur, Universitat de València ( UV ), Max-Planck-Institut für Sonnensystemforschung ( MPS ), Matière et Systèmes Complexes ( MSC ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre universitaire de Cytométrie, Imagerie et Mathématiques ( CIM ), Université de Limoges ( UNILIM ) -CHU Limoges, Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Canadian Food Inspection Agency ( CFIA ), Institut Jean-Nicod ( IJN ), Département d'Etudes Cognitives - ENS Paris ( DEC ), École normale supérieure - Paris ( ENS Paris ) -École normale supérieure - Paris ( ENS Paris ) -École des hautes études en sciences sociales ( EHESS ) -Centre National de la Recherche Scientifique ( CNRS ) -Département de Philosophie - ENS Paris, École normale supérieure - Paris ( ENS Paris ), Laboratoire d'Etudes Sociolinguistiques sur les Contacts de Langues et la Politique Linguistique ( LESCLAP ), Centre d'Immunologie de Marseille - Luminy ( CIML ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Droit Privé et de Sciences Criminelles ( LDPSC ), Aix Marseille Université ( AMU ), IFP Energies nouvelles ( IFPEN ), Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée ( DAPNIA ), European Southern Observatory ( ESO ), Centre de Recherches Pétrographiques et Géochimiques ( CRPG ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Lille - Economie et Management ( LEM ), Centre National de la Recherche Scientifique ( CNRS ) -Université catholique de Lille ( UCL ) -Université de Lille, Centre interuniversitaire de recherche et d'ingenierie des matériaux ( CIRIMAT ), Institut National Polytechnique [Toulouse] ( INP ) -Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique ( CNRS ), Astrophysikalisches Institut Potsdam, University of Las Palmas de Gran Canaria ( ULPGC ), Nordic Optical Telescope ( NOT ), Instituto de Astrofisica de Canarias ( IAC ), Royal Institute of Technology [Stockholm] ( KTH ), Instituto de Astrofísica de Andalucía ( IAA ), Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Institute of Space and Astronautical Science ( ISAS ), Instituto Nacional de Engenharia, Tecnologia e Inovacco ( INETI ), INETI, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Laboratoire Microorganismes : Génome et Environnement ( LMGE ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Centre National de la Recherche Scientifique ( CNRS ) -Université d'Auvergne - Clermont-Ferrand I ( UdA ), Observatoire astronomique de Strasbourg ( OAS ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS ), Centre d'études spatiales de la biosphère ( CESBIO ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National d'Etudes Spatiales ( CNES ) -Centre National de la Recherche Scientifique ( CNRS ), Technische Universität Dresden ( TUD ), European Space Research and Technology Centre [ESTEC], Galaxies, Etoiles, Physique, Instrumentation [GEPI], Centre for Research in Earth and Space Science [Toronto] [CRESS], Agence Spatiale Européenne = European Space Agency [ESA], Centre National d'Études Spatiales [Toulouse] [CNES], University of California [San Diego] [UC San Diego], Nelson Mandela University [Port Elizabeth], Joseph Louis LAGRANGE [LAGRANGE], European Space Astronomy Centre [ESAC], Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires [EA 2992], Systèmes de Référence Temps Espace [SYRTE], Mullard Space Science Laboratory [MSSL], Institut de Mécanique Céleste et de Calcul des Ephémérides [IMCCE], Royal Observatory of Belgium [Brussels] [ROB], Alma Mater Studiorum Università di Bologna [Bologna] [UNIBO], Institut d'astrophysique spatiale [IAS], Astrophysique Interprétation Modélisation [AIM (UMR7158 / UMR_E_9005 / UM_112)], Université de Picardie Jules Verne [UPJV], Laboratoire Univers et Particules de Montpellier [LUPM], Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) [UTINAM], University of Cambridge [UK] [CAM], United States Geological Survey [Reston] [USGS], Récepteurs et Canaux Ioniques Membranaires [RCIM], Universitat de Barcelona [UB], Institute of Environmental Assessment and Water Research [IDAEA], Institut de Planétologie et d'Astrophysique de Grenoble [IPAG], Observatoire aquitain des sciences de l'univers [OASU], Laboratoire d'Astrophysique de Bordeaux [Pessac] [LAB], Observatoire Astronomique de l'Université de Genève [ObsGE], Institut de Chimie Moléculaire de Reims - UMR 7312 [ICMR], Centre d'étude spatiale des rayonnements [CESR], Activité Physique, Muscle, Santé [EA4488], Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies [SISSA / ISAS], INAF - Osservatorio Astronomico di Bologna [OABO], Géoazur [GEOAZUR 7329], Institut de recherches sur la catalyse et l'environnement de Lyon [IRCELYON], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] [UNIROMA], Institut de Systématique, Evolution, Biodiversité [ISYEB ], Institut de Physique et Chimie des Matériaux de Strasbourg [IPCMS], Federal University of Para - Universidade Federal do Pará - UFPA [Belém, Brazil] [UFPA], Observatoire astronomique de Strasbourg [ObAS], Sciences Pour l'Oenologie [SPO], SRON Netherlands Institute for Space Research [SRON], The Institute of Environmental Medicine [Stockholm] [IMM], Virulence bactérienne et maladies infectieuses [VBMI], Institut de Physique de Rennes [IPR], Institut de chimie et procédés pour l'énergie, l'environnement et la santé [ICPEES], Institut de Chimie de Clermont-Ferrand [ICCF], Chinese Academy of Sciences [Beijing] [CAS], Atmel Corporation [ATMEL], Probabilités, statistique, physique mathématique [PSPM], Astrophysics Research Institute [Liverpool] [ARI], Institut Non Linéaire de Nice Sophia-Antipolis [INLN], Matériaux, ingénierie et science [Villeurbanne] [MATEIS], Institut de Recherche sur la Fusion par confinement Magnétique [IRFM], INAF - Osservatorio Astronomico di Trieste [OAT], Laboratoire SUBATECH Nantes [SUBATECH], Laboratoire de l'Accélérateur Linéaire [LAL], Laboratoire de Physico -& Toxico Chimie des systèmes naturels [LPTC], Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM], Département Réseaux, Information, Multimédia [RIM-ENSMSE], Équipes de Recherches Interlangues : Mémoires, Identités, Territoires [ERIMIT], INAF - Osservatorio Astrofisico di Torino [OATo], Ben-Gurion University of the Negev [BGU], Westfälische Wilhelms-Universität Münster = University of Münster [WWU], Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM], Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research [MPS], Matière et Systèmes Complexes [MSC], Centre universitaire de Cytométrie, Imagerie et Mathématiques [CIM], Institut Cochin [IC UM3 (UMR 8104 / U1016)], Institut Jean-Nicod [IJN], Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University [UNESP], Centre d'Immunologie de Marseille - Luminy [CIML], Laboratoire de Droit Privé et de Sciences Criminelles [LDPSC], IFP Energies nouvelles [IFPEN], Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée [DAPNIA], Lineberger Comprehensive Cancer Center [UNC Lineberger], European Southern Observatory [ESO], Centre de Recherches Pétrographiques et Géochimiques [CRPG], Centre interuniversitaire de recherche et d'ingenierie des matériaux [CIRIMAT], Leibniz Institute for Astrophysics Potsdam [AIP], University of Las Palmas de Gran Canaria [ULPGC], Nordic Optical Telescope [NOT], Royal Institute of Technology [Stockholm] [KTH ], Instituto de Astrofísica de Andalucía [IAA], Institute of Space and Astronautical Science [ISAS], Laboratoire Microorganismes : Génome et Environnement [LMGE], Sans affiliation, Observatoire astronomique de Strasbourg [OAS], and Centre d'études spatiales de la biosphère [CESBIO]
Subjects: [ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], FOS: Physical sciences, Astrometry, Proper motion, Astronomy and Astrophysic, Settore FIS/05 - Astronomia e Astrofisica, proper motions, surveys, catalogs / astrometry / parallaxes / proper motions / surveys, Space and Planetary Science, parallaxes, Catalog, Navigations- und Regelungssysteme, Astrophysics - Instrumentation and Methods for Astrophysics, Parallaxe, Survey, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Catalogs, Parallaxes, Proper motions, Surveys, Instrumentation and Methods for Astrophysics (astro-ph.IM), catalogs
Abstract: At about 1000 days after the launch of Gaia we present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7. We summarize Gaia DR1 and provide illustrations of the scientific quality of the data, followed by a discussion of the limitations due to the preliminary nature of this release. Gaia DR1 consists of: a primary astrometric data set which contains the positions, parallaxes, and mean proper motions for about 2 million of the brightest stars in common with the Hipparcos and Tycho-2 catalogues and a secondary astrometric data set containing the positions for an additional 1.1 billion sources. The second component is the photometric data set,consisting of mean G-band magnitudes for all sources. The G-band light curves and the characteristics of ~3000 Cepheid and RR Lyrae stars, observed at high cadence around the south ecliptic pole, form the third component. For the primary astrometric data set the typical uncertainty is about 0.3 mas for the positions and parallaxes, and about 1 mas/yr for the proper motions. A systematic component of ~0.3 mas should be added to the parallax uncertainties. For the subset of ~94000 Hipparcos stars in the primary data set, the proper motions are much more precise at about 0.06 mas/yr. For the secondary astrometric data set, the typical uncertainty of the positions is ~10 mas. The median uncertainties on the mean G-band magnitudes range from the mmag level to ~0.03 mag over the magnitude range 5 to 20.7. Gaia DR1 represents a major advance in the mapping of the heavens and the availability of basic stellar data that underpin observational astrophysics. Nevertheless, the very preliminary nature of this first Gaia data release does lead to a number of important limitations to the data quality which should be carefully considered before drawing conclusions from the data., Comment: 23 pages, 13 figures. This paper has 591 co-authors. Accepted by A&A in the Gaia Special Feature. The Gaia data, documentation and access facilities can be found at http://archives.esac.esa.int/gaia/

34. Metastatic "Ductal Carcinoma In Situ-Like" Lobular Carcinoma in a Lymph Node: A Case Report and Review of the Literature.

Author: Tijani S, Sharma K, Yuen H, and Shaaban A
Subjects: Axilla, Biomarkers, Tumor analysis, Biomarkers, Tumor metabolism, Breast diagnostic imaging, Breast pathology, Breast surgery, Carcinoma, Intraductal, Noninfiltrating secondary, Carcinoma, Intraductal, Noninfiltrating surgery, Carcinoma, Lobular secondary, Carcinoma, Lobular surgery, Diagnosis, Differential, Diagnostic Errors prevention & control, Female, Humans, Lymph Node Excision, Lymphatic Metastasis pathology, Mammography, Mastectomy, Middle Aged, Breast Neoplasms pathology, Carcinoma, Intraductal, Noninfiltrating diagnosis, Carcinoma, Lobular diagnosis, Lymph Nodes pathology, Lymphatic Metastasis diagnosis
Abstract: Metastatic breast cancer resembling ductal carcinoma in situ (DCIS) is a rare phenomenon. In this article, we present a unique case of metastatic lobular carcinoma with DCIS-like morphology in the left axillary lymph nodes of a 52-year-old female. She presented with 2 lesions in the left breast on mammography, and a mastectomy with axillary lymph node dissection was performed. Gross examination showed a 3.5 × 2.5 × 1.0 cm indistinct tumor in the lower outer quadrant and a 2.5 × 2.5 × 1.8 cm tumor in the upper outer quadrant. Microscopic assessment revealed a pleomorphic lobular carcinoma in the lower outer quadrant and a grade 2 invasive ductal carcinoma in the upper outer quadrant. Sixteen of the 17 axillary lymph nodes showed metastatic lobular carcinoma with foci of solid and comedo-type DCIS-like features. Immunohistochemical analysis of the primary and metastatic lobular carcinoma showed no expression of E-cadherin and p63 antibodies. To our knowledge, metastatic lobular carcinoma exhibiting this pattern has not been reported. The case suggests that lobular carcinoma can morphologically recreate a primary microenvironment at a distant site and simulate in situ growth. Recognition of this pattern is important to avoid misdiagnosis.
Published: 2020
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34 results on '"Queens Elizabeth Hospital [Birmingham]"'

1. Testing the efficacy and safety of BIO101, for the prevention of respiratory deterioration, in patients with COVID-19 pneumonia (COVA study): a structured summary of a study protocol for a randomised controlled trial

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34. Metastatic "Ductal Carcinoma In Situ-Like" Lobular Carcinoma in a Lymph Node: A Case Report and Review of the Literature.

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34 results on '"Queens Elizabeth Hospital [Birmingham]"'

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