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30 results on '"Quarta, SANTINA MARIA"'

2. SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity

Author

Turato, Cristian, Cannito, Stefania, Simonato, Davide, Villano, Gianmarco, Morello, Elisabetta, Terrin, Liliana, Quarta, SANTINA MARIA, Biasiolo, Alessandra, Ruvoletto, Mariagrazia, Martini, Andrea, Fasolato, Silvano, Zanus, Giacomo, Cillo, Umberto, Gatta, Angelo, Parola, Maurizio, and Pontisso, Patrizia

Subjects
0301 basic medicine, Genetically modified mouse, Carcinoma, Hepatocellular, Transcription, Genetic, Carcinogenesis, Regulator, Mice, Transgenic, Serpin, medicine.disease_cause, Article, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, Mice, 0302 clinical medicine, Antigens, Neoplasm, medicine, Animals, Humans, Serpins, Adaptor Proteins, Signal Transducing, Hippo signaling pathway, Multidisciplinary, biology, Effector, Calpain, Liver Neoplasms, YAP-Signaling Proteins, Hep G2 Cells, Phosphoproteins, Gene Expression Regulation, Neoplastic, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Transcription Factors
Abstract

SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the potential mechanistic role of this serpin in tumor development is still poorly understood. Overexpression of Myc often correlates with more aggressive tumour forms, supporting its involvement in carcinogenesis. Yes-associated protein (Yap), the main effector of the Hippo pathway, is a central regulator of proliferation and it has been found up-regulated in hepatocellular carcinomas. The study has been designed to investigate and characterize the interplay and functional modulation of Myc by SerpinB3 in liver cancer. Results from this study indicate that Myc was up-regulated by SerpinB3 through calpain and Hippo-dependent molecular mechanisms in transgenic mice and hepatoma cells overexpressing human SerpinB3 and also in human hepatocellular carcinomas. Human recombinant SerpinB3 was capable to inhibit the activity of Calpain in vitro, likely reducing its ability to cleave Myc in its non oncogenic Myc-nick cytoplasmic form. SerpinB3 indirectly increased the transcription of Myc through the induction of Yap pathway. These findings provide for the first time evidence that SerpinB3 can improve the production of Myc through direct and indirect mechanisms that include the inhibition of generation of its cytoplasmic form and the activation of Yap pathway.

Published
2015

3. RUOLO DI SERPINB3 ELLA PROGRESSIONE DELLA MALATTIA EPATICA

Author

Quarta, SANTINA MARIA, Ruvoletto, Mariagrazia, Biasiolo, Alessandra, Turato, Cristian, Villano, Gianmarco, Tono, N, Ciscato, Francesco, Crescenzi, Marika, Martini, A, Gatta, Angelo, and Pontisso, Patrizia

Published
2011

10. SERPINB3 AND TGF-BETA IN CHRONIC LIVER DISEASE

Author

Turato, Cristian, Calabrese, Fiorella, Biasiolo, Alessandra, Quarta, SANTINA MARIA, Ruvoletto, Mariagrazia, Tono, N, Franzosi, L, Paccagnella, D, Fassina, G, Gatta, Angelo, and Pontisso, Patrizia

Published
2009

15. SERPINB3 PROMUOVE L’INVASIVITA’ CELLULARE

Author

Quarta, SANTINA MARIA, Vidalino, Laura, Turato, Cristian, Ruvoletto, Mariagrazia, Calabrese, Fiorella, Valente, Marialuisa, Fassina, G, Gatta, Angelo, and Pontisso, Patrizia

Published
2008

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