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405 results on '"Quaranta N"'

1. In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization

Author

Gelardi M, Bosoni M, Morelli M, Beretta S, Incorvaia C, Buttafava S, Landi M, Masieri S, Frati F, Quaranta N, and Zuccotti GV

Subjects
allergic rhinitis, polysensitization, nasal inflammation, nasal cytology, ragweed pollen, grass pollen., Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Matteo Gelardi,1 Mariangela Bosoni,2 Marco Morelli,2 Silvia Beretta,2 Cristoforo Incorvaia,3 Serena Buttafava,4 Massimo Landi,5 Simonetta Masieri,6 Franco Frati,4 Nicola Quaranta,1 Gian Vincenzo Zuccotti21Otolaryngology Section, Department of Neuroscience and Sensory Organs, University of Bari, 2Department of Pediatrics, Luigi Sacco Hospital, University of Milan, 3Allergy/Pulmonary Rehabilitation Unit, ICP Hospital, 4Medical and Scientific Department, Stallergenes Italy, Milan, 5Department of Pediatrics, ASL TO1, Turin, 6Department of Otorhinolaryngology, Sapienza University of Rome, Rome, ItalyBackground: In patients polysensitized to pollen allergens, the priming effect, by which the sensitivity of the nasal mucosa to an allergen is increased by the previous exposure to another allergen, is a known phenomenon. This study was aimed at evaluating the degree of nasal inflammation, assessed by nasal cytology, in children with allergic rhinitis (AR) from ragweed pollen according to being monosensitized or polysensitized.Methods: The study included 47 children. Of them, 24 suffered from AR caused by sensitization to grass pollen and ragweed pollen (group A) and 23 were sensitized only to ragweed pollen (group B). In all patients, the severity of AR was assessed according to the Allergic Rhinitis and Its Impact on Asthma guidelines, and comorbidities were also evaluated.Results: In group A, 16.7% of children had a mild intermittent AR, 4.2% a moderate-to-severe intermittent, 33.3% a mild persistent, and 45.8% a moderate-to-severe persistent; in group B, 26.1% of children had a mild intermittent AR, 0% a moderate-to-severe intermittent, 52.2% a mild persistent, and 21.7% a moderate-to-severe persistent. No significant difference was detected in the number of the considered comorbidities between the two groups. The cell counts of neutrophils, eosinophils, lymphocytes/plasma cells, and mast cells were high but not significantly different in the two groups.Conclusion: These findings show that the degree of nasal inflammation found in children with ragweed-induced AR is not influenced by additional allergy to grass pollen and confirm the previously reported absence of priming effect in ragweed allergy.Keywords: allergic rhinitis, pollen sensitization, priming effect, nasal cytology, eosinophils, neutrophils

Published
2016

2. Seasonal changes in nasal cytology in mite-allergic patients

Author

Gelardi M, Peroni DG, Incorvaia C, Quaranta N, De Luca C, Barberi S, Dell'Albani I, Landi M, Frati F, and de Beaumont O

Subjects
Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Matteo Gelardi,1 Diego G Peroni,2 Cristoforo Incorvaia,3 Nicola Quaranta,1 Concetta De Luca,1 Salvatore Barberi,4 Ilaria Dell'Albani,5 Massimo Landi,6 Franco Frati,5 Olivier de Beaumont7 1Otolaryngology Unit, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy; 2Department of Pediatrics, University of Verona, Verona, Italy; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 4Department of Pediatrics, San Paolo Hospital, Milan, Italy; 5Medical and Scientific Department, Stallergenes, Milan, Italy; 6Department of Pediatrics, National Healthcare System, ASL TO1, Turin, Italy; 7Medical Affairs Department, Stallergenes, Antony, France Background: House dust mites (HDMs) are a major cause of allergic rhinitis (AR) and asthma worldwide. Recent studies suggested that the allergen load presents seasonal modifications, giving rise to seasonal variation in nasal inflammation and symptoms. The aim of this study was to evaluate by nasal cytology whether nasal inflammation in mite-allergic patients changes with the seasons of the year. Methods: The study included 16 patients (seven males and nine females, mean age 38.1 years) with persistent AR caused by monosensitization to HDMs. Nasal cytology was performed in all patients once monthly for 1 year. Results: Nasal cytology showed that the cells most commonly detected in the nasal mucosa were neutrophils. During the period from October to April, a peak in the number of neutrophils and also the presence of significant numbers of eosinophils, mast cells, and lymphocytes/plasma cells were found, which shows the occurrence of more intense inflammation during these months. Conclusion: Nasal cytology provides useful data in detecting nasal inflammation and its association with the clinical stage of AR. The seasonal variations in nasal cytology are likely to be induced by the fluctuations in the HDM allergen that have been uncovered in recent investigations. Keywords: allergens, allergic rhinitis, house dust mite, nasal inflammation

Published
2014

4. A preliminary study of the linear relationship between monthly averaged daily solar radiation and daily thermal amplitude in the north of Buenos Aires province

Author

Cionco, R., Quaranta, N., and Rodriguez, R.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Using irradiance and temperature measurements obtained at the Facultad Regional San Nicol\'as of UTN, we performed a preliminary study of the linear relationship between monthly averaged daily solar radiation and daily thermal amplitude. The results show a very satisfactory adjustment (R = 0.848, RMS = 0.066, RMS% = 9.690 %), even taking into account the limited number of months (36). Thus, we have a formula of predictive nature, capable of estimating mean monthly solar radiation for various applications. We expect to have new data sets to expand and improve the statistical significance of these results., Comment: Conference paper, ASADES 2012 (Asociaci\'on Argentina de Energ\'ias Renovables y Ambiente). Accepted (poster). 6 pages, 3 figures

Published
2012

10. The diagnostic accuracy of late-life depression is influenced by subjective memory complaints and educational level in an older population in Southern Italy

Author

Lozupone, M., D'Urso, F., Copetti, M., Sardone, R., Arcuti, S., Castellana, F., Galizia, I., Lofano, L., Veneziani, F., Piccininni, C., Barulli, M. R., Grasso, A., Battista, P., Tortelli, R., Capozzo, R., Griseta, C., Doricchi, F., Quaranta, N., Resta, E., Daniele, Antonio, Seripa, D., Solfrizzi, V., Bellomo, Alberto, Logroscino, Giandomenico, Panza, F., Daniele A. (ORCID:0000-0003-1641-5852), Bellomo A., Logroscino G. (ORCID:0000-0003-1301-5343), Lozupone, M., D'Urso, F., Copetti, M., Sardone, R., Arcuti, S., Castellana, F., Galizia, I., Lofano, L., Veneziani, F., Piccininni, C., Barulli, M. R., Grasso, A., Battista, P., Tortelli, R., Capozzo, R., Griseta, C., Doricchi, F., Quaranta, N., Resta, E., Daniele, Antonio, Seripa, D., Solfrizzi, V., Bellomo, Alberto, Logroscino, Giandomenico, Panza, F., Daniele A. (ORCID:0000-0003-1641-5852), Bellomo A., and Logroscino G. (ORCID:0000-0003-1301-5343)

Abstract

The prevalence of late-life depression (LLD) depends on the study sample, measurements, and diagnostic approaches. We estimated the 30 item-Geriatric Depression Scale (GDS-30) accuracy against the gold standard LLD diagnosis made with the Semi-structured Clinical Diagnostic Interview for DSM-IV-TR Axis I Disorders, focusing on the prevalence of a late-life major depressive disorder (MDD), in a population-based sample of 843 subjects aged>65 years, subdivided into three groups: normal cognition, subjective memory complaints, and mild cognitive impairment. At the optimal cut-off score (≥4), the GDS-30 showed 65.1% sensitivity and 68.4% specificity for LLD (63% and 66% for late-life MDD, respectively). Using the standard cut-off score (≥10), the GDS-30 specificity reached 91.2%, while sensitivity dropped to 37.7%, indicating a lower screening accuracy [area under the curve(AUC):0.728, 95% confidence interval(CI):0.67–0–78]. The GDS-30 performance was associated with educational level, but not with age, gender, cognition, apathy, and somatic/psychiatric multimorbidity. For subjective memory complaints subjects, at the optimal cut-off score (≥7), the GDS-30 showed better discrimination performances (AUC=0.792,95%CI:0.60–0.98), but again the educational level affected the diagnostic performance. In subjective memory complaints subjects, symptom-based scales like the GDS-30 may feature a better performance for diagnosing depression in older age, but the GDS-30 seems to require adjustment to the patient's educational level.

Published
2022

11. Analysis of tinnitus severity and associated risk factors in patients with chronic otitis media: data from the multinational collaborative Chronic Otitis Media Questionnaire-12 study

Author

Tailor, B V, primary, Phillips, J S, additional, Nunney, I, additional, Yung, M W, additional, Doruk, C, additional, Kara, H, additional, Kong, T, additional, Quaranta, N, additional, Peñaranda, A, additional, Bernardeschi, D, additional, Dai, C, additional, Kania, R, additional, Denoyelle, F, additional, and Tono, T, additional

Published
2022
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13. Materias primas no tradicionales en la industria cerámica

Author

Caligaris, R., Quaranta, N., Caligaris, M., and Benavidez, E.

Subjects
Ceramic materials, raw material, recycling, wastes, densification, Materiales cerámicos, materias primas, reciclado, residuos, densificación, Clay industries. Ceramics. Glass, TP785-869
Abstract

The wastes incorporation to the production cycle is an interesting alternative in modern industry. This gives rise to not only an economical profit but to a considerable decrease in environmental impact. Studies made about recycling of several wastes: glass, electric insulators and fly ash are compared in this work. The materials were crushed and separated by particle size distribution in order to prepare representative samples. Different treatment steps were carried out as is usual in the process of ceramic industries. Some of the obtained powders were used without additives while other were mixed in different ratios with other ceramic components in order to improve their final properties. All the compacts, obtained by uniaxial pressing of the powders, received thermal treatments which were adequate to their compositions. They were then characterised by several techniques including dilatometry, X ray diffraction, porosity, microhardness, optical and scanning electron microscopy and energy dispersion analysis (SEM/EDX). From this investigation it was concluded that the studied materials constitute a potential source of raw materials for the ceramic industry.La incorporación de materiales de desecho en el ciclo productivo es una alternativa de interés en la industria moderna que conduce tanto a un beneficio económico como a una considerable reducción del impacto sobre el medio ambiente. En este trabajo se comparan estudios realizados sobre la reutilización de diversos residuos: vidrio, aisladores eléctricos y cenizas volantes. Estos materiales fueron molidos y clasificados por tamaño de partículas para ser usados en la preparación de muestras representativas. Las diferentes etapas de tratamiento se establecieron según los procesos habituales de producción de la industria cerámica. Algunos de los polvos obtenidos se utilizaron sin aditivos, mientras que otros fueron mezclados en distintas proporciones con diversos componentes cerámicos con el fin de mejorar sus propiedades finales. Todos los compactos, obtenidos por prensado uniaxial de estos polvos, recibieron tratamientos térmicos adecuados a sus composiciones, para luego ser caracterizados por diversas técnicas entre las que se pueden mencionar: dilatometría, difracción de rayos X, porosidad, microdureza, microscopías óptica y electrónica de barrido y análisis por dispersión de energías. Del análisis de los resultados obtenidos en estos estudios, se concluyó que los materiales ensayados constituyen una potencial fuente de materia prima para la industria cerámica.

Published
2000

14. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in Ménière’s disease and vestibular neuritis

Author

Quaranta, N. A. A., Salzo, A. E., Pontillo, V., Scarano, Emanuele, Sergi, Bruno, Picciotti, Pasqualina Maria, Scarano E. (ORCID:0000-0003-2570-1121), Sergi B. (ORCID:0000-0001-8648-5966), Picciotti P. M. (ORCID:0000-0002-1502-6508), Quaranta, N. A. A., Salzo, A. E., Pontillo, V., Scarano, Emanuele, Sergi, Bruno, Picciotti, Pasqualina Maria, Scarano E. (ORCID:0000-0003-2570-1121), Sergi B. (ORCID:0000-0001-8648-5966), and Picciotti P. M. (ORCID:0000-0002-1502-6508)

Abstract

Objective: several hypothesis including viral infection, vascular disturbance, and immune-mediated mechanisms have been proposed in Menière disease (MD) and vestibular neuritis (VN) and the role of inflammation has been also investigated. To evaluate the role of neutrophil to lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and metabolic parameters in MD and VN patients. Methods: we retrospectively studied 120 subjects (40 affected by MD, 40 by VN and 40 normal controls). We analyzed glycaemia, Haematocrit Blood Test (HCT), leukocytes, neutrophils, lymphocytes, platelets, cholesterol, prothrombin time and the related international normalized ratio (PT-INR), fibrinogen, erythrocyte sedimentation rate (ESR), NLR and PLR. Results: Neutrophils, leukocytes, cholesterol, ESR, NLR and PLR values of MD patients are significantly higher than normal controls. Higher significant values are reported for glycaemia, neutrophils, lymphocytes, leucocyte, fibrinogen, ESR, NLR and PLR in VN patients compared to NC. Conclusions: High levels of NLR and PLR indicate the presence of an acute inflammatory state in both MD and VN. Our data confirm the role of proinflammatory state leading to microvascular injury together with risk factors for atherogenesis. © 2021 International Association of Physicians in Audiology.

Published
2021

16. Clinical-Cytological-Grading and phenotyping in patients with chronic rhinosinusitis with nasal polyps: the relevance in clinical practice

Author

Gelardi, M., Porro, G., Quaranta, V., Quaranta, N., Cassano, M., Ciprandi, G., Luigi, Alonzi, Arturo Arnone Caruso, Francesco, Barbara, Michele, Barbara, Paolo, Castelnuovo, Giovanna, Ciancio, Ciofalo, Andrea, Michele, Curatolo, Nicola De Candia, Carlo De Luca, Valentina De Robertis, Valentina Di Benedetto, Valeria, Fiore, Lucia, Iannuzzi, Clara, Imperatore, Cristiano, Lingua, Giuseppe, Lombardo, Alberto, Macchi, Michela, Mancini, Alessandro Maselli del Giudice, Patrizia, Mola, Mario, Notargiacomo, Antonio, Palma, Piero, Pecoraro, Giuseppe, Pellitteri, Krizia, Piccininni, Massimo, Rinaldi, and Valentina, Rossi. Study Group On CRSwNP I.

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, Allergy, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, real-world, cytological phenotype, Chronic rhinosinusitis, lcsh:Medicine, Comorbidity, chronic rhinosinusitis with nasal polyps, Nasal Polyps, Internal medicine, clinical-cytological-grading, Eosinophilic, Outcome Assessment, Health Care, medicine, Hypersensitivity, Prevalence, Humans, Nasal polyps, Sinusitis, Grading (tumors), Asthma, Retrospective Studies, Aspirin, business.industry, lcsh:R, Cell Biology, Middle Aged, medicine.disease, asthma, comorbidity, Clinical Practice, Cross-Sectional Studies, Phenotype, Italy, Chronic Disease, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Chronic rhinosinusitis (CRS) includes two main phenotypes: without nasal polyps (CRSsNP) and with nasal polyps (CRSwNP). CRSwNP may be associated with comorbidity, mainly concerning asthma, aspirin intolerance, and allergy. CRSwNP patients may also be evaluated by clinical-cytological grading (CCG). The current study investigated the prevalence and characteristics of the different CCG and phenotypes in CRSwNP outpatients examined in clinical practice. This retrospective cross-sectional study enrolled 791 consecutive CRSwNP outpatients (424 males, mean age 48.8 years). In the total population, asthma was a common comorbidity (30.8%) as well as aspirin intolerance (24.8%), and allergy (50.8%). As concerns CCG-grading, 210 (26.5%) outpatients had low-grade, 366 (46.3%) medium, and 215 (27.2%) high. As regards cytological phenotypes, 87 (11%) had neutrophilic type, 371 (46.3%) eosinophilic, 112 (14.2%) mast cell, and 221 (27.9%) mixed. High-grade CCG was significantly associated with more frequent asthma, aspirin intolerance, allergy, recurrent surgery, and mixed cytological phenotype. Low-grade CCG was characterized by fewer comorbidities and operations, and neutrophilic phenotype. Therefore, the present study confirmed that CCG is a useful tool in the management of outpatients with CRSwNP. CRSwNP is frequently associated with asthma, aspirin intolerance, and allergy comorbidity. High-grade CCG is frequently characterized by a mixed cytological phenotype, thus, by more severe progress. These real-world outcomes underline that CRSwNP deserves adequate attention for careful management and optimal identification of the best-tailored therapy; CCG and cytological phenotyping could be fruitful tools in clinical practice. Asthma and aspirin intolerance should be adequately investigated in all CRS patients.

Published
2020

18. Author's reply to the Letter to the Editor 'Therapeutic strategies in the treatment of Menière's disease: the Italian experience'

Author

Quaranta, N, Picciotti, P, Picciotti, P (ORCID:0000-0002-1502-6508), Quaranta, N, Picciotti, P, and Picciotti, P (ORCID:0000-0002-1502-6508)

Abstract

There is still controversy on the role of hyperinsulinemia and endogenous antisecretory factor (EAF) in Meniere's disease. In the literature, there is no mention on glucose uptake or specially processed cereals (SPC). Nevertheless, the role of EAF and its inhibition by SPC should be taken into account in future research. In case of patients not responding to medical treatment and dietary changes, intratympanic (IT) treatment has been suggested. In Italy, generalists consider IT steroids as the first-line treatment, while neurotologists suggest IT gentamicin. We agree with the authors that low-dose IT gentamicin has a high chance to treat vertigo with minimal risks for hearing; however, a recent randomized, double-blind, comparative trial has not proven the superiority of gentamicin to IT steroids suggesting the choice "should be made based on clinical knowledge and patient circumstances". IT steroids have the advantage to preserve both cochlear and vestibular function, while IT gentamicin has an ablative effect especially on the vestibular function.

Published
2020

25. Therapeutic strategies in the treatment of Menière's disease: the Italian experience

Author

Quaranta, N., Picciotti, Pasqualina Maria, Porro, G., Sterlicchio, B., Danesi, G., Petrone, P., Asprella Libonati, G., Picciotti P. (ORCID:0000-0002-1502-6508), Quaranta, N., Picciotti, Pasqualina Maria, Porro, G., Sterlicchio, B., Danesi, G., Petrone, P., Asprella Libonati, G., and Picciotti P. (ORCID:0000-0002-1502-6508)

Abstract

Purpose: Ménière's disease (MD) is an inner ear disorder of unknown etiology, whose pathological substrate is the endolymphatic hydrops. Different treatments have been proposed; however, evidence of their effectiveness is lacking. The aim of this study was to evaluate by a questionnaire which medical and surgical treatments are used in Italy for the treatment of MD and to compare them with those proposed in other countries. Methods: An electronic questionnaire of 40 questions was formulated and sent to Italian otolaryngologist (ENT) divided into two groups: Group 1 (“generalists” 60.8%) and Group 2 (“neurotologist- NO” 39.2%). Results: One hundred and twenty five ENT replied. Treatment of the acute phase, apart from symptomatics, was based on diuretics that are prescribed by 83.5% of respondents, steroids, prescribed by 66.7%, and vasodilators, prescribed by 22%. In the intercritical phase, 87.2% of respondents recommended low-salt diet, 78.4% of respondents prescribed betahistine, and 52.8% diuretics. Statistical analysis did not show correlation neither with the declared specialization nor with the number of patients treated. In case of failure of medical treatment, IT gentamicin was suggested by 48.8% of the respondents and IT steroids by 40.8%. Statistical analysis showed that generalists prefer IT steroids and NO IT gentamicin (p 0.019). In case of failure of both medical treatment and IT treatment, vestibular neurectomy was indicated by 58.4% of the respondents, 6.4% indicated endolymphatic sac surgery, and 2.4% surgical labyrinthectomy. Conclusion: In Italy, the treatment of MD stand on a gradual approach that starts from the dietary-behavioral changes and a pharmacological therapy based on betahistine. In refractory cases, IT treatment initially with steroids and, therefore, with gentamicin allows the control in vertigo in the majority of cases. In case of failure of IT treatment, VNS is the surgery of choice.

Published
2019

30. Relieving laryngopharingeral reflux (RELIEF) survey in otolaryngology - II the viewpoint of the patient

Author

Gelardi, M., Silvestrf, M., Ciprandp, G., Aielli, F., Alessandrini, P., Allosso, G., Angelillo, S., Anni, A., Antoniacomi, G., Aragona, S. E., Armone Caruso, A., Asprea, F., Azzaro, R., Balata, G., Bellini, C., DI BENEDETTO, Daniela, Bernardi, R., Buccolieri, M., Caligo, G., Campobasso, G., Canevari, F. R., Cantaffa, A., Capone, A., Carboni, S., Castagna, G., Castellani, C., Clemente, I., Cordier, A., Cossu, D., Costanzo, M., Cugno Garrano, A., Cupido, G., Danteo, M., De Luca, C., Degli Innocenti, M., Dei, A., Denuli, G., Di Bartolo, L., Dolores, A., Falcetti, S., Falciglia, AURORA MARIA ROSARIA, Fera, G., Ferraro, G., Fini, O., Giangregorio, F., Grazioli, F., Grillo, C., Guiso, M. L., Ianniello, F., Lerace, M., Ingria, F., La Mantia, I., La Pietra, G., Lambertoni, C., Lauletta, R., Lazzoni, D., Leo, S., Leone, M., Lo Iacono, Y., Maio, M., Mangiatordi, F. G., Maniscalco, F., Matricciani, A., Mirra, N., Montanaro, S. C., Montesi, P., Moro, D., Muiit, F., Mure, C., Nacci, A., Nipo, Tarsia, Pace, Annamaria, Panetti, G., Paoletti, M., Pasquarella, G., Pedrotti, I., Pellegrino, A., Petrone, D., Pinto, P., Pizzolante, M. C., Pollastrini, L., Poma, S., Quaranta, N., Reale, G., Rigo, S., Scarpa, A., Scelsi, F., Sellari, L., Serraino, E. G., Spano', Piero Giovanni Maria, Stufano, V., Tomacelli, G., Tombolini, A., and Zirone, A.

Published
2018

36. Cartilage ossiculoplasty in cholesteatoma surgery: hearing results and prognostic factors

Author

QUARANTA, N., TALIENTE, S., COPPOLA, F., and SALONNA, I.

Subjects
Cholesteatoma, Middle Ear, Otology, Prognosis, Ossicular Prosthesis, Cartilage, Treatment Outcome, Ossiculoplasty, otorhinolaryngologic diseases, Audiometry, Pure-Tone, Humans, Surgery, Cholesteatoma, Follow-Up Studies, Retrospective Studies
Abstract

Cartilage tympanoplasty is an established procedure for tympanic membrane and attic reconstruction. Cartilage has been used as an ossiculoplasty material for many years. The aim of this study was to evaluate hearing results of costal cartilage prostheses in ossicular chain reconstruction procedures in subjects operated on for middle ear cholesteatoma and to determine the presence of prognostic factors. Candidates for this study were patients affected by middle ear cholesteatoma whose ossicular chain was reconstructed with a chondroprosthesis. 67 cases of ossiculoplasty with total (TORP) or partial (PORP) chondroprosthesis were performed between January 2011 and December 2013. Follow-up examination included micro-otoscopy and pure tone audiometry. The guidelines of the Committee on Hearing and Equilibrium of the American Academy of Otolaryngology Head and Neck Surgery were followed and pure-tone average (PTA) was calculated as the mean of 0.5, 1, 2 and 4 kHz thresholds. Statistical analysis was performed with ANOVA tests and regression models. Average air-bone gap (ABG) significantly improved from 39.2 dB HL (SD 9.1 dB HL) to 25.4 dB HL (SD 11 dB HL) (p0.001). Linear regression analysis showed that the only prognostic factor was the type of operation (p = 0.02). In fact, patients submitted to ICWT presented better post-operative ABG compared to CWDT. None of the other variables influenced the results. The present study proposes costal cartilage as material of choice when autologous ossicles are not available. The maintenance of the posterior canal wall was the only prognostic factor identified.La cartilagine è comunemente utilizzata per la ricostruzione della membrana timpanica e dell'attico in corso di timpanoplastica. Nella nostra esperienza la cartilagine costale omologa è stata utilizzata per molti anni per la creazione di protesi ossiculari. Scopo di questo studio è stato quello di valutare i risultati funzionali dell'ossiculoplastica con condroprotesi e di identificare fattori prognostici. Abbiamo valutato pazienti affetti da otite media cronica colesteatomatosa la cui catena ossiculare è stata ricostruita mediante condroprotesi. 67 soggetti sono stati sottoposti a ossiculoplastica totale (TORP) o parziale (PORP) tra gennaio 2011 e dicembre 2013. Per la valutazione dei risultati uditivi sono state utilizzate le Linee Guida della "Committee on Hearing and Equilibrium" dell'American Academy of Otolaryngology Head and Neck. L'analisi statistica dei risultati è stata eseguita con test ANOVA e modelli di regressione lineare. Il gap via aerea-via ossea (ABG) migliorava significativamente dopo ossiculoplastica da 39,2 dB HL (DS 9,1 dB HL) a 25,4 dB HL (DS 11 dB HL) (p0,001). L'analisi statistica ha dimostrato che l'unico fattore prognostico è stato il tipo di tecnica chirurgica utilizzata. Infatti, i pazienti sottoposti a timpanoplastica chiusa hanno presentato miglior ABG postoperatorio rispetto alla timpanoplastica aperta (p = 0,02). Tutte le altre variabili analizzate non hanno influenzato i risultati uditivi. La cartilagine costale è il nostro materiale scelta per la creazione di protesi ossiculari quando gli ossicini autologhi non sono disponibili. La tecnica chirurgica (timpanoplastica chiusa) si è dimostrata quale unico fattore prognostico positivo.

Published
2015

37. Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life

Author

Panza, F., Lozupone, M., Sardone, R., Battista, P., Piccininni, M., Dibello, V., La Montagna, M., Stallone, R., Venezia, P., Liguori, A., Giannelli, G., Bellomo, A., Greco, A., Daniele, A., Seripa, D., Quaranta, N., Logroscino, G., Liguori A., Bellomo A., Greco A., Daniele A. (ORCID:0000-0003-1641-5852), Panza, F., Lozupone, M., Sardone, R., Battista, P., Piccininni, M., Dibello, V., La Montagna, M., Stallone, R., Venezia, P., Liguori, A., Giannelli, G., Bellomo, A., Greco, A., Daniele, A., Seripa, D., Quaranta, N., Logroscino, G., Liguori A., Bellomo A., Greco A., and Daniele A. (ORCID:0000-0003-1641-5852)

Abstract

The peripheral hearing alterations and central auditory processing disorder (CAPD) associated with age-related hearing loss (ARHL), may impact cognitive disorders in older age. In older age, ARHL is also a significant marker for frailty, another age-related multidimensional clinical condition with a nonspecific state of vulnerability, reduced multisystem physiological reserve, and decreased resistance to different stressors (i.e. sensorial impairments, psychosocial stress, diseases, injuries). The multidimensional nature of frailty required an approach based on different pathogeneses because this clinical condition may include sensorial, physical, social, nutritional, cognitive, and psychological phenotypes. In the present narrative review, the cumulative epidemiological evidence coming from several longitudinal population-based studies, suggested convincing links between peripheral ARHL and incident cognitive decline and dementia. Moreover, a few longitudinal case-control and population-based studies also suggested that age-related CAPD in ARHL, may be central in determining an increased risk of incident cognitive decline, dementia, and Alzheimer’s disease (AD). Cumulative meta-analytic evidence confirmed cross-sectional and longitudinal association of both peripheral ARHL and age-related CAPD with different domains of cognitive functions, mild cognitive impairment, and dementia, while the association with dementia subtypes such as AD and vascular dementia remained unclear. However, ARHL may represent a modifiable condition and a possible target for secondary prevention of cognitive impairment in older age, social isolation, late-life depression, and frailty. Further research is required to determine whether broader hearing rehabilitative interventions including coordinated counseling and environmental accommodations could delay or halt cognitive and global decline in the oldest old with both ARHL and dementia.

Published
2018

38. A Multicenter Clinical Evaluation of Data Logging in Cochlear Implant Recipients Using Automated Scene Classification Technologies

Author

Cristofari, E, Cuda, D, Martini, A, Forli, F, Zanetti, D, Di Lisi, D, Marsella, P, Marchioni, D, Vincenti, V, Aimoni, C, Paludetti, G, Barezzani, Mg, Leone, Ca, Quaranta, N, Bianchedi, M, Presutti, L, Della Volpe, A, Cantore, I, Frau, Gm, Orzan, E, Galletti, F, Vitale, S, Raso, F, Negri, M, Trabalzini, F, Livi, W, Piccioni, Lo, Ricci, G, and Malerba, P

Subjects
Automatic SCAN, Cochlear implant listening habits, Cochlear implants in noise, Data logging
Published
2017

42. Cochlear implant in incomplete partition type I

Author

Berrettini, Stefano, Forli, Francesca, DE VITO, Andrea, Bruschini, Luca, and Quaranta, N.

Subjects
Male, Infant, Cochlear Implantation, Inner ear malformations, Cochlea, Cochlear Implants, Child, Preschool, Incomplete partition, otorhinolaryngologic diseases, Humans, Case Series, Abnormalities, Multiple, Female, Vestibule, Labyrinth, Cochlear implant, Gusher, Child
Abstract

In this investigation, we report on 4 patients affected by incomplete partition type I submitted to cochlear implant at our institutions. Preoperative, surgical, mapping and follow-up issues as well as results in cases with this complex malformation are described. The cases reported in the present study confirm that cochlear implantation in patients with incomplete partition type I may be challenging for cochlear implant teams. The results are variable, but in many cases satisfactory, and are mainly related to the surgical placement of the electrode and residual neural nerve fibres. Moreover, in some cases the association of cochlear nerve abnormalities and other disabilities may significantly affect results.In questo articolo vengono descritte le problematiche e i risultati riguardanti la procedura di impianto cocleare in quattro pazienti affetti da partizione incompleta tipo I, sottoposti ad impianto cocleare nel nostro reparto. Le problematiche pre-operatorie, chirurgiche, di mappaggio e riguardanti il follow-up, così come i risultati vengono affrontate e discusse. I casi riportati nel presente articolo confermano che la procedura di impianto cocleare in pazienti affetti da partizione incompleta tipo I può rappresentare una sfida per i teams che si occupano di impianto cocleare. I risultati sono variabili, ma in molti casi soddisfacenti e sono soprattutto in relazione al posizionamento intra-cocleare dell'elettrodo e ai residui neurali. Inoltre in alcuni casi i risultati possono essere fortemente condizionati dall'associazione di anomalie del nervo acustico e dalla presenza di disabilità associate alla sordità.

Published
2013

43. Human-centered agriculture fighting exploitation and racism

Author

Diabaté, I., Quaranta, N., Diabaté, I., and Quaranta, N.

Abstract

While much of the production of food in Europe depends on migrant workers, most people are not aware of the terrible working and living conditions that most of them have to endure. At the same time the plight of small scale producers, who must deal with the low prices imposed by large retailers, also goes unnoticed. In Calabria, South Italy, small scale producers and migrant workers are coming together to practice ethical agriculture.

Published
2017

44. Ciliocytophthoria: Cytomorphologic Modifications in Viral Infections of the Nasal Mucosa

Author

Quaranta N, Seccia, Gelardi M, and Lannuzzi L

Subjects
Rhinology, medicine.medical_specialty, Pathology, Nasal cytology, business.industry, Medicine, Mean age, Mucous membrane of nose, Respiratory system, University hospital, business, Omics, Giemsa stain
Abstract

The term ciliocytophthoria (CCP) (Greek etymology) describes a degenerative phenomenon of the ciliated cells secondary to respiratory viral infections and characterized by specific morphological changes. In the winter 2014-2015, we examined 12 patients, aged between 12 and 32 years (mean age 21, F/M: 4/8) who attended the clinic of Rhinology of the University Hospital Center of Bari (Italy) with a viral infection of the upper airways. All subjects underwent nasal cytology for microscopic examination and preparations were stained using the technique of May-Grunwald Giemsa. Our study describes CCP precisely in all its developmental stages by means of microscopic examination of the nasal mucosa (nasal cytology).

Published
2016
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45. The effect of alpha-lipoic acid on temporary threshold shift in humans: a preliminary study

Author

Quaranta N, Dicorato A, Matera V, D'Elia A, and Nicola Quaranta

Subjects
Adult, Male, Alpha-lipoic acid, Young Adult, Thioctic Acid, Hearing protection, otorhinolaryngologic diseases, Humans, Auditory Threshold, Female, Audiology, Noise-induced hearing loss, Antioxidants
Abstract

Noise-induced hearing loss (NHIL) is a significant source of hearing loss in industrialized countries. Recent research on the cellular bases of NIHL has led to new avenues for protection through prophylactic drugs. Although in experimental animal models several compounds have shown a protective effect in NIHL, limited data are available in humans. Many authors are focusing their attention on the role of antioxidant on hearing protection. Alpha-lipoic acid (ALA), an essential cofactor in mitochondrial enzymes, is a novel biological antioxidant and a potent free radical scavenger and, in animal models, it has been shown to protect from age-induced and cisplatin-induced hearing loss. The aim of our study was to evaluate the effect of alpha-lipoic acid on temporary threshold shift measured 2 minutes after the end of exposure (TTS(2)) induced by a 3 kHz tone in young normally hearing subjects. Thirty young normal hearing volunteers served as control subjects. Individuals were randomly assigned to three groups. Group A (10 subjects) subjects were exposed to a 90 dB HL 3 kHz pure tone for 10 min. Group B (10 subjects) subjects were exposed to a 90 dB HL 3 kHz pure tone one hour after oral ingestion of 600 mg of ALA. Group C (10 subjects) were exposed to a 90 dB HL 3 kHz pure tone after 10 days of oral ingestion of 600 mg of ALA. Statistical analysis showed that prior to the exposure the hearing thresholds did not differ significantly among the three groups. TTS(2) of group C was significantly lower that TTS2 of Groups A and B at 6 kHz (p 0.03), and TEOAEs amplitude change after noise exposure was lower for group C compared to Groups A (p = 0.089) and B (p = 0.03). ALA is a powerful lipophilic antioxidant and free radical scavenger currently used in clinical practice. A single dose of 600 mg of dose ALA did not induce any protection on the TTS(2) induced by a 90 dB HL 3 kHz tone, while 10 days of therapeutic dosage assumption of ALA was associated with significant protection at 6 kHz. The results of this study show that a short course of ALA protects from TTS(2) in humans, and therefore further studies are needed to better define the role of ALA in the prevention of noise induced hearing loss.RIASSUNTOL'ipoacusia da rumore è un'importante causa di sordità nei paesi industrializzati. Recenti ricerche sulle basi biologiche della sordità da rumore hanno condotto a nuove prospettive per quanto riguarda la prevenzione farmacologica. Sebbene gli esperimenti condotti su animali abbiano dimostrato l'efficacia di numerosi composti nella prevenzione del danno da rumore, pochi dati sono ad oggi disponibili nell'uomo. Molti autori stanno concentrando la loro attenzione sul ruolo di protezione degli antiossidanti dal danno da rumore. L'acido alfa-lipoico (ALA), un importante cofattore degli enzimi mitocondriali, è un nuovo antiossidante biologico ed un potente scavenger dei radicali liberi. In modelli animali è stata dimostrata la sua efficacia nella protezione dall'ipoacusia età-correlata e cisplatino-indotta. L'obiettivo del nostro studio è stato quello di valutare l'effetto dell'acido alfa lipoico sull'innalzamento temporaneo di soglia indotto da un tono puro a 3 kHz in giovani soggetti normoudenti. Trenta giovani volontari sono stati utilizzati come soggetti di studio e suddivisi in tre gruppi. Il Gruppo A (10 soggetti) è stato esposto ad un tono puro di 90 dB HL a 3 kHz per dieci minuti. Il Gruppo B (10 soggetti) è stato esposto ad un tono puro di 90 dB HL a 3 kHz un'ora dopo l'assunzione per os di 600 mg di acido alfa-lipoico (ALA). Il Gruppo C (10 soggetti) é stato esposto ad un tono puro di 90 dB HL a 3 kHz dopo dieci giorni dall'assunzione per os di 600 mg di ALA. Prima dell'esposizione a rumore la soglia uditiva dei tre gruppi non mostrava differenze statisticamente significative. La TTS del Gruppo C é risultata invece significativamente piú bassa di quella dei Gruppi A e B a 6 kHz (p 0.03) e la variazione di ampiezza delle TEOAEs per il Gruppo C é risultata significativamente piú bassa di quella del Gruppo A (p = 0.089) e del gruppo B (p = 0.03). L'ALA é pertanto un potente antiossidante lipofilico e scavenger dei radicali liberi attualmente utilizzato nella pratica clinica. Una singola dose di ALA di 600 mg non induce alcuna protezione sulla TTS provocata dall'esposizione ad un tono puro di 90 dB HL a 3 kHz, ma é possibile ottenere una protezione statisticamente significativa attraverso l'assunzione per dieci giorni di ALA a dosaggio terapeutico. Il nostro studio dimostra quindi che un breve trattamento con ALA protegge dal danno da rumore nell'uomo e pertanto ulteriori ricerche sono necessarie per meglio definire il ruolo di ALA nella prevenzione del danno da rumore.

Published
2012

46. The Clinical Stage of Allergic Rhinitis is Correlated to Inflammation as Detected by Nasal Cytology

Author

Gelardi, M, Incorvaia, C, Fiorella, Ml, Petrone, P, Quaranta, N, Russo, C, Puccinelli, P, Dell'Albani, I, Riario Sforza GG, Cattaneo, E, Passalacqua, G, Frati, F, Italian Academy of Nasal Cytology, Boccardo, R, Bocciolini, C, Caruso, G, Ciofalo, A, Dall'Olio, D, Landi, M, Maffezzoni, E, Poletti, D, Salerni, Lorenzo, Tomaiuolo, M, and Troiano, L.

Subjects
Adult, Male, medicine.medical_specialty, Allergen immunotherapy, Lymphocyte, Cytological Techniques, Immunology, ARIA guidelines, Inflammation, Severity of Illness Index, Gastroenterology, Allergic rhinitis, nasal cytology, Diagnosis, Differential, Internal medicine, medicine, Humans, Immunology and Allergy, Stage (cooking), Sensitization, Asthma, Pharmacology, business.industry, Rhinitis, Allergic, Seasonal, General Medicine, medicine.disease, Staining, Nasal Mucosa, medicine.anatomical_structure, Female, Nasal administration, medicine.symptom, business
Abstract

Allergic rhinitis (AR) is the most common allergic disease. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines classify AR according to its duration and severity and suggest recommended treatments, but there is evidence that these guidelines are insufficiently followed. Considering the validity of histopathological data, physicians are more likely to be persuaded by such information on AR. Thus, we attempted to define the severity of AR by nasal cytology on the basis of the ARIA classification. We examined 64 patients with AR caused by sensitization to grass pollen. We clinically defined AR according to the ARIA classification and performed nasal cytology by Rhino-probe sampling, staining and reading by optical microscopic observation. Clinically, 22 (34.4%), 21 (32.8%), 10 (15.6%), and 11 (17.2%) patients had mild intermittent, moderate-to-severe intermittent, mild persistent, and moderate-to-severe persistent AR, respectively. Nasal cytology detected neutrophils in 49 patients, eosinophils in 41 patients, mast cells in 21 patients, and lymphocytes or plasma cells in 28 patients. The patients with moderate-to-severe AR had significantly more mast cells and lymphocytes/ plasma cells than those with mild AR. Our findings demonstrate that the ARIA classification of AR severity is associated with different cell counts in nasal cytology; especially, moderate-to-severe AR shows significantly increased counts of mast cells and lymphocyte or plasma cells. The ease of performing nasal cytology ensures is feasibility as an office AR diagnostic procedure for primary care physicians, able to indicate when anti-inflammatory treatments, such as intranasal corticosteroids and subcutaneous or sublingual allergen immunotherapy, are needed.

Published
2011
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47. A registry for the collection of data in cochlear implant patients

Author

Berrettini S, Arslan E, Baggiani A, Burdo S, Cassandro E, Cuda D, Dinelli E, Filipo R, Patrizia Mancini, Martini A, Quaranta A, Quaranta N, Turchetti G, and Forli F

Subjects
Registry, Cochlear Implants, Health Records, Personal, Italy, Humans, cochlear implant, cochlear implant recipient, registry, Registries, Cochlear implant, Cochlear implant recipient, Research Article
Abstract

SUMMARY The need to optimize the use of all the information that modern technological tools have made available to the physician ENT/audiologist has increasingly emerged within the Italian scientific community. Towards this purpose, it is necessary to create a registry of the patients using cochlear implants (CIs). This registry will include a homogeneous summary of the information deriving from multiple sources related to daily clinical practice, in order to assess auditory benefits, safety and reliability in patients with cochlear implants, and organization over the national territory. The primary objectives relative to the above-mentioned analysis are to assess the impact of the use of cochlear implants on patient health, to ensure traceability of the devices currently used, monitoring their safety and reliability over time, to guarantee access of the technique in clinical and organizational conditions that can allow the best possible benefits. The aspects concerning implementation of the registry were discussed extensively during the first meetings of the Working Group (WG). In particular, owing to the complexity and high costs related mainly to the development of the technological aspects and the need to involve technological partners external to the WG, and to respect current privacy laws, the WG members decided that the project should be limited to proposal of a paper registry to be implemented at a later stage, possibly within the framework of successive research projects. During meetings, the WG members discussed various aspects of implementation of the registry, and in particular the scientific features connected to objectives, inclusion criteria, and structure of the forms needed for data collection and organizational aspects. A registry is proposed herein.

Published
2011

48. Idiopathic sudden sensorineural hearing loss and ménière syndrome: The role of cerebral venous drainage

Author

Ciccone, M. M., primary, Scicchitano, P., additional, Gesualdo, M., additional, Cortese, F., additional, Zito, A., additional, Manca, F., additional, Boninfante, B., additional, Recchia, P., additional, Leogrande, D., additional, Viola, D., additional, Damiani, M., additional, Gambacorta, V., additional, Piccolo, A., additional, De Ceglie, V., additional, and Quaranta, N., additional

Published
2017
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50. Hearing loss and cognitive decline in older adults: Questions and answers

Author

Bernabei, R, Bonuccelli, U, Maggi, S, Marengoni, Alessandra, Martini, A, Memo, Maurizio, Pecorelli, Sergio, Peracino, A, Quaranta, N, Stella, R, Lin, F, Berrettini, S, Bertolotti, A, Canale, A, Castiglione, A, Cristofari, E, Cuda, D, De Caria, A, Folco, E, Gabelli, C, Genovese, E, Ghidoni, E, Leone, Ca, Mauri, Marta Rosa Maria, Padovani, Alessandro, Paludetti, G, Pirodda, A, Postiglione, A, REDAELLI DE ZINIS, Luca Oscar, Tortelli, R., Roberto Bernabei, Ubaldo Bonuccelli, Stefania Maggi, Alessandra Marengoni, Alessandro Martini, Maurizio Memo, Sergio Pecorelli, Andrea P. Peracino, Nicola Quaranta, Roberto Stella, Frank R. Lin, For the participants in the Workshop on Hearing Loss and Cognitive Decline in Older Adults [.., Antonio Pirodda, and ]

Subjects
Questions and answers, Gerontology, Age-related hearing loss, Cognitive decline, Dementia, Interdisciplinary collaboration, Sensory therapy, Animals, Cognition, Cognition Disorders, Hearing Loss, Humans, Aging, Geriatrics and Gerontology, Medicine (all), Hearing loss, media_common.quotation_subject, MEDLINE, Presentation, Cognition Disorder, otorhinolaryngologic diseases, Medicine, Association (psychology), Hearing Lo, cognitive impairment, media_common, business.industry, Animal, Settore MED/09 - MEDICINA INTERNA, medicine.disease, Age-related hearing lo, Settore MED/32 - AUDIOLOGIA, Settore MED/31 - OTORINOLARINGOIATRIA, medicine.symptom, business, Human
Abstract

The association between hearing impairment, the diagnosis of dementia, and the role of sensory therapy has been proposed for some time, but further research is needed. Current understanding of this association requires the commitment of those experts who can integrate experience and research from several fields to be able to understand the link from hearing to dementia. A workshop whose panelists included experts from many areas, ranging from ear, nose and throat (ENT) to dementia's specialists, was promoted and organized by the Giovanni Lorenzini Medical Science Foundation (Milan, Italy; Houston, TX, USA) to increase the awareness of the relationship between hearing loss and dementia, and included questions and comments following a presentation from the clinical researcher, Frank Lin, who has been evaluating the relationship between hearing loss and cognitive decline since 2009.

Published
2014

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