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4. Project ECHO Revisited: Propensity Score Analysis And HCV Treatment Outcomes

Author

Page K, Qeadan F, Qualls C, Thornton K, and Arora S

Subjects
propensity scoring, ECHO, hepatitis C virus, treatment, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Kimberly Page,1,2 Fares Qeadan,1,2 Clifford Qualls,2 Karla Thornton,1 Sanjeev Arora1 1Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA; 2Clinical and Translational Science Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USACorrespondence: Kimberly PageDepartment of Internal Medicine, University of New Mexico Health Sciences Center, MSC10 5550, 1 University of New Mexico, Albuquerque, NM 98131, USATel +1505-272-2520Email Pagek@salud.unm.eduAbstract: Propensity score analysis is a statistical approach to reduce bias often present in non-randomized observational studies. In this paper we use this method to re-analyze data from a study that assessed whether patients receiving HCV treatment from providers in Project ECHO had different clinical outcomes than patients treated by specialists from an academic medical center (UNM HCV clinic) but in which treatment assignment was not randomized. We modeled the best estimated probability of treatment assignment, and then assess differences overall SVR and SVR in patients with genotype 1 infection by treatment arm using Stabilized Inverse Probability of Treatment Weights (SIPTW). Results show that after adjustment for SIPTW, HCV treatment outcomes were significantly better for the ECHO patients compared to the UNM HCV clinic patients. Higher proportions of patients treated by primary care providers achieved SVR and SVR with genotype 1 compared to those treated at UNM HCV clinic with 15.1% and 16.3% absolute differences, respectively. These results indicate that previously published results (showing no differences) were biased, and resulted in an underestimation of the treatment effect of ECHO on HCV treatment.Keywords: propensity scoring, ECHO, hepatitis C virus, treatment

Published
2019

7. Harmonization of criteria and terminology in fetal rat skeletal evaluations

Author

Posobiec, L. M., primary, Kopp, C., additional, Murzyn, S. M., additional, Olitan, T., additional, Rendemonti, J., additional, French, J., additional, Tamborini, E., additional, Campey, J., additional, Longo, M., additional, Danberry, T., additional, Vaillancourt, M., additional, Nowland, W., additional, Daoud, M., additional, Qualls, C., additional, and Harris, S. B., additional

Published
2023
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10. Sex-specific muscle and metabolic biomarkers associated with gait speed and cognitive transitions in older adults: a 9-year follow-up

Author

Waters, D. L., Vlietstra, L., Qualls, C., Morley, J. E., and Vellas, B.

Abstract

Physical frailty and cognitive frailty share biological mechanisms, but sex-specific biomarkers associated with transitions in gait speed and cognition during ageing are poorly understood.Gait speed, cognition (3MSE), body composition (DXA) and serological biomarkers were assessed annually over 9 years in 216 males (72.7 + 8.07 years) and 384 females (71.1 +8.44 years). In females, maintaining normal gait speed was associated with lower percent body fat (IRR 0.793, p= 0.001, 95%CI 0.691–0.910) and lower lactate dehydrogenase (LDH) (IRR 0.623, p = 0.00, 95%CI 0.514–0.752), and in males, the association was with higher cholesterol (IRR 1.394, p= 0.001, 95%CI 1.154–1.684). Abnormal to normal gait speed transitions were associated with higher insulin in females (IRR 1.325, p= 0.022, 95%CI 1.041–1.685) and lower creatinine in males (IRR 0.520, p= 0.01, 95%CI 0.310–0.870). Normal to slow gait speed transitions in males were associated with IGF-1 (IRR 1.74, p= 0.022, 95%CI 1.08–2.79) and leptin in females (IRR 1.39, p= 0.043, 95%CI 1.01–1.91.) Maintaining normal cognition was associated with lower LDH in females (IRR 0.276, p= 0.013, 95%CI 0.099–0.765) and higher appendicular skeletal muscle mass in males (IRR 1.52, p= 0.02, 95%CI 1.076–2.135). Improved cognition was associated with higher leptin (IRR 7.5, p= 0.03, 95%CI 1.282–44.34) and lower triglyceride (IRR 0.299, p= 0.017, 95%CI 0.110–0.809) in males. Education was protective against cognitive decline in females (IRR 0.84, p= 0.037, 0.732–0.982). Sex-specific biomarkers of muscle (LDH, Creatinine, IGF-1, APSM) and metabolism (%fat, insulin,cholesterol, leptin, tryglycerides) were associated with gait speed and cognitive transitions. These data suggest that modifiable biomarkers of muscle and metabolism could be targeted for interventions.

Published
2024
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46. The combined presence of CD20 + B cells and PD-L1 + tumor-infiltrating lymphocytes in inflammatory breast cancer is prognostic of improved patient outcome

Author

Arias-Pulido, H., primary, Cimino-Mathews, A., additional, Chaher, N., additional, Qualls, C., additional, Joste, N., additional, Colpaert, C., additional, Marotti, J. D., additional, Foisey, M., additional, Prossnitz, E. R., additional, Emens, L. A., additional, and Fiering, S., additional

Published
2018
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