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597 results on '"Quagliarella A"'

1. Letermovir for Cytomegalovirus infection in pediatric patients undergoing allogenic hematopoietic stem cell transplantation: a real-life study by the Infectious Diseases Working Group of Italian Association of Pediatric Hematology-Oncology (AIEOP)

Author

Galaverna, Federica, Baccelli, Francesco, Zama, Daniele, Tridello, Gloria, Masetti, Riccardo, Soncini, Elena, Mura, Rossella, Barzaghi, Federica, Colombini, Antonella, Prunotto, Giulia, D’Amico, Maria Rosaria, Calore, Elisabetta, Biffi, Alessandra, Perruccio, Katia, Gasperini, Pietro, Oltolini, Chiara, Quagliarella, Francesco, Giacomazzi, Alice, Pagliara, Daria, Locatelli, Franco, and Cesaro, Simone

Published
2024
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2. Krueger High-Lift System Design Optimization

Author

Iuliano, Emiliano, Quagliarella, Domenico, Wild, Jochen, Oñate, Eugenio, Series Editor, Tuovinen, Tero, editor, Periaux, Jacques, editor, Knoerzer, Dietrich, editor, Bugeda, Gabriel, editor, and Pons-Prats, Jordi, editor

Published
2024
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3. Mucosal-associated invariant T cells are functionally impaired in pediatric and young adult patients following allogeneic hematopoietic stem cell transplantation and their recovery correlates with clinical outcomes

Author

Federica Galaverna, Sara Flamini, Carmen Dolores De Luca, Ilaria Pili, Emilia Boccieri, Francesca Benini, Francesco Quagliarella, Chiara Rosignoli, Marco Rosichini, Shirley Genah, Marialuigia Catanoso, Antonella Cardinale, Gabriele Volpe, Marianna Coccetti, Angela Pitisci, Giuseppina Li Pira, Roberto Carta, Barbarella Lucarelli, Francesca Del Bufalo, Valentina Bertaina, Marco Becilli, Daria Pagliara, Mattia Algeri, Pietro Merli, Franco Locatelli, and Enrico Velardi

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Mucosal-associated invariant T (MAIT) cells are innate-like T-cells implicated in the response to fungal and bacterial infections. Their contribution to restoring T-cell immunity and influencing hematopoietic stem cell transplant (HSCT) outcomes remains poorly understood. We retrospectively studied MAIT-cell recovery in 145 consecutive children and young adults with hematological malignancies undergoing allo-HSCT, between April/2019 and May/2022, from unrelated matched donor (MUD, n=52), with standard graft-versus-host-disease (GvHD) prophylaxis, or HLA-haploidentical (Haplo, n=93) donor after in vitro αβT/CD19-cell depletion, without post-HSCT pharmacological prophylaxis. With a median follow-up of 33 months (12-49), overall survival (OS), disease-free survival (DFS) and non-relapse mortality (NRM) were 79.5%, 72% and 7%, respectively; GvHD-free, Relapse-free Survival (GRFS) was 63%, while cumulative incidence of relapse was 23%. While WWT-cells reconstituted 1-2 years post-HSCT, MAIT-cells showed delayed recovery and prolonged functional impairment, characterized by expression of activation (CD25, CD38), exhaustion (PD1, TIM3) and senescence (CD57) markers, and suboptimal ex vivo response. OS, DFS and NRM were not affected by MAIT-cells. Interestingly, higher MAIT-cells at day+30 correlated with higher incidence of grade II-IV acute GvHD (19% vs 7%, p=0.06). Furthermore, a greater MAIT-cell count tended to be associated with a higher incidence of chronic GvHD (17% vs 6%, p=0.07) resulting in lower GRFS (55% vs 73%, p=0.05). Higher MAIT-cells also correlated with greater cytomegalovirus (CMV) reactivation and lower late blood stream infections (BSI) (44% vs 24%, p=0.02 and 9% vs 18%, p=0.08, respectively). Future studies are needed to confirm the impact of early MAIT-cell recovery on cGvHD, CMV reactivation and late BSI.

Published
2024
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4. Analytical Benchmark Problems for Multifidelity Optimization Methods

Author

Mainini, L., Serani, A., Rumpfkeil, M. P., Minisci, E., Quagliarella, D., Pehlivan, H., Yildiz, S., Ficini, S., Pellegrini, R., Di Fiore, F., Bryson, D., Nikbay, M., Diez, M., and Beran, P.

Subjects
Mathematics - Optimization and Control, Computer Science - Computational Engineering, Finance, and Science
Abstract

The paper presents a collection of analytical benchmark problems specifically selected to provide a set of stress tests for the assessment of multifidelity optimization methods. In addition, the paper discusses a comprehensive ensemble of metrics and criteria recommended for the rigorous and meaningful assessment of the performance of multifidelity strategies and algorithms.

Published
2022

6. Amphiregulin, ST2, and REG3α biomarker risk algorithms as predictors of nonrelapse mortality in patients with acute GVHD

Author

Etra, Aaron, El Jurdi, Najla, Katsivelos, Nikolaos, Kwon, Deukwoo, Gergoudis, Stephanie, Morales, George, Spyrou, Nikolaos, Kowalyk, Steven, Aguayo-Hiraldo, Paibel, Akahoshi, Yu, Ayuk, Francis, Baez, Janna, Betts, Brian C., Chanswangphuwana, Chantiya, Chen, Yi-Bin, Choe, Hannah, DeFilipp, Zachariah, Gleich, Sigrun, Hexner, Elizabeth, Hogan, William J., Holler, Ernst, Kitko, Carrie L., Kraus, Sabrina, Al Malki, Monzr, MacMillan, Margaret, Pawarode, Attaphol, Quagliarella, Francesco, Qayed, Muna, Reshef, Ran, Schechter, Tal, Vasova, Ingrid, Weisdorf, Daniel, Wölfl, Matthias, Young, Rachel, Nakamura, Ryotaro, Ferrara, James L. M., Levine, John E., and Holtan, Shernan

Published
2024
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8. Efficient Attack-Surface Exploration for Electromagnetic Fault Injection

Author

Carta, Daniele Antonio Emanuele, Zaccaria, Vittorio, Quagliarella, Gabriele, Molteni, Maria Chiara, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Kavun, Elif Bilge, editor, and Pehl, Michael, editor

Published
2023
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9. TCRαβ/CD19 cell–depleted HLA-haploidentical transplantation to treat pediatric acute leukemia: updated final analysis

Author

Merli, Pietro, Algeri, Mattia, Galaverna, Federica, Bertaina, Valentina, Lucarelli, Barbarella, Boccieri, Emilia, Becilli, Marco, Quagliarella, Francesco, Rosignoli, Chiara, Biagini, Simone, Girolami, Elia, Meschini, Antonella, Del Principe, Giovanna, Sborgia, Raffaella, Catanoso, Maria Luigia, Carta, Roberto, Strocchio, Luisa, Pinto, Rita Maria, Buldini, Barbara, Falco, Michela, Meazza, Raffaella, Pende, Daniela, Andreani, Marco, Li Pira, Giuseppina, Pagliara, Daria, and Locatelli, Franco

Published
2024
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23. αβT- and B-cell-depleted HLA-haploidentical hematopoietic stem cell transplantation in children with myelodysplastic syndromes

Author

Pietro Merli, Daria Pagliara, Tommaso Mina, Valentina Bertaina, Giuseppina Li Pira, Stefania Lazzaro, Simone Biagini, Federica Galaverna, Luisa Strocchio, Roberto Carta, Maria Luigia Catanoso, Francesco Quagliarella, Marco Becilli, Emilia Boccieri, Francesca Del Bufalo, Arianna Panigari, Annalisa Agostini, Lucia Pedace, Simone Pizzi, Cesare Perotti, Mattia Algeri, Marco Zecca, and Franco Locatelli

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
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26. Value-at-Risk and Conditional Value-at-Risk in Optimization Under Uncertainty

Author

Quagliarella, Domenico, Schröder, Wolfgang, General editor, Boersma, Bendiks Jan, Series Editor, Fujii, Kozo, Series Editor, Haase, Werner, Series Editor, Hirschel, Ernst Heinrich, Founded by, Leschziner, Michael A., Series Editor, Periaux, Jacques, Series Editor, Pirozzoli, Sergio, Series Editor, Rizzi, Arthur, Series Editor, Roux, Bernard, Series Editor, Shokin, Yurii I., Series Editor, Hirsch, Charles, editor, Wunsch, Dirk, editor, Szumbarski, Jacek, editor, Łaniewski-Wołłk, Łukasz, editor, and Pons-Prats, Jordi, editor

Published
2019
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27. UQ Sensitivity Analysis and Robust Design Optimization of a Supersonic Natural Laminar Flow Wing-Body

Author

Quagliarella, Domenico, Iuliano, Emiliano, Schröder, Wolfgang, General editor, Boersma, Bendiks Jan, Series Editor, Fujii, Kozo, Series Editor, Haase, Werner, Series Editor, Hirschel, Ernst Heinrich, Founded by, Leschziner, Michael A., Series Editor, Periaux, Jacques, Series Editor, Pirozzoli, Sergio, Series Editor, Rizzi, Arthur, Series Editor, Roux, Bernard, Series Editor, Shokin, Yurii I., Series Editor, Hirsch, Charles, editor, Wunsch, Dirk, editor, Szumbarski, Jacek, editor, Łaniewski-Wołłk, Łukasz, editor, and Pons-Prats, Jordi, editor

Published
2019
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29. Case Report: Trichosporon japonicum Fungemia in a Pediatric Patient With Refractory Acute B Cell Lymphoblastic Leukemia

Author

Sami Albitar-Nehme, Marilena Agosta, Agata Helena Kowalska, Livia Mancinelli, Manuela Onori, Barbara Lucignano, Giordana Mattana, Francesco Quagliarella, Maria Giuseppina Cefalo, Pietro Merli, Franco Locatelli, Carlo Federico Perno, and Paola Bernaschi

Subjects
Trichosporon japonicum, acute B cell lymphoblastic leukemia, MALDI-TOF MS biotyper, voriconazole, amphotericin B, Pediatrics, RJ1-570
Abstract

Trichosporon japonicum is a very rare opportunistic yeast causing fungal disease in humans, especially in immunocompromised hosts. Here, we describe a new case of T. japonicum isolated from the blood of a pyrexial pediatric patient with refractory acute B cell lymphoblastic leukemia and acute respiratory distress. Prompt diagnosis through early clinical suspicion and appropriate molecular microbiology analysis allowed the yeast to be accurately identified at species level. Subsequent drug susceptibility testing and focused antifungal treatment with voriconazole and amphotericin B led to a complete clinical and mycological resolution of the infection, which represents the second successful case of T. japonicum bloodstream infection described in literature to date.

Published
2022
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31. Optimization Under Uncertainty Using the Generalized Inverse Distribution Function

Author

Quagliarella, Domenico, Petrone, Giovanni, and Iaccarino, Gianluca

Subjects
Mathematics - Optimization and Control, Computer Science - Neural and Evolutionary Computing
Abstract

A framework for robust optimization under uncertainty based on the use of the generalized inverse distribution function (GIDF), also called quantile function, is here proposed. Compared to more classical approaches that rely on the usage of statistical moments as deterministic attributes that define the objectives of the optimization process, the inverse cumulative distribution function allows for the use of all the possible information available in the probabilistic domain. Furthermore, the use of a quantile based approach leads naturally to a multi-objective methodology which allows an a-posteriori selection of the candidate design based on risk/opportunity criteria defined by the designer. Finally, the error on the estimation of the objectives due to the resolution of the GIDF will be proven to be quantifiable, Comment: 20 pages, 25 figures

Published
2014

32. Is There Anyone in There?”: Caregivers and Professionals’ Mutual Positioning to Take Care of Vegetative State Patients

Author

Fatigante, M, Zucchermaglio, C, Alby, F, Zulato, E, Montali, L, Quagliarella, C, Zulato, E., Montali, L., Quagliarella, C., Fatigante, M, Zucchermaglio, C, Alby, F, Zulato, E, Montali, L, Quagliarella, C, Zulato, E., Montali, L., and Quagliarella, C.

Abstract

The vegetative state is a condition in which a person is wakeful without being aware. To understand a patient who can be considered neither alive nor dead, caregivers and professionals re-define traditional identities, roles, and practices. By drawing on wider research, in the current chapter, we aimed to show how caregivers and practitioners positioned the patient and themselves within the institutional context of five nursing homes in Lombardy. We conducted 65 semi-structured interviews with 35 caregivers (sons, partners, parents) and 30 professionals (health, mental health professionals, and social workers). Our discourse analysis identified three different interpretative repertoires to position the patient: an organic, an interactional, and a possibilistic one. Their encounter both leads to disagreement and convergence. In particular, by taking each other’s perspective, professionals and caregivers might converge toward the common ground of balanced hope, where the possibility for patients’ awareness is neither fostered nor denied. In this space of possibilities, caregivers find a justification for their monitoring and patient stimulation activity and take on the role of spokesperson for the patient. This common ground allows them to communicate, justify their reciprocal action and acknowledge their roles and expertise in taking care of the patient.

Published
2023

42. Hematopoietic Stem/Progenitor Cells and Engineering: LONG-TERM DATA ON IMMUNE MONITORING OF CHILDREN GIVEN TCRαβ/CD19 CELL DEPLETED HLA-HAPLOIDENTICAL STEM TRANSPLANTATION (HAPLO-HSCT)

Author

Bertaina, V., primary, Sborgia, R., additional, Marini, O., additional, De Luca, C., additional, Carta, R., additional, Becilli, M., additional, Pagliara, D., additional, Quagliarella, F., additional, Lucarelli, B., additional, Boccieri, E., additional, Velardi, E., additional, Algeri, M., additional, Merli, P., additional, Galaverna, F., additional, and Locatelli, F., additional

Published
2023
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44. Is There Anyone in There?': Caregivers and Professionals’ Mutual Positioning to Take Care of Vegetative State Patients

Author

Edoardo Zulato, Lorenzo Montali, Carolina Quagliarella, Fatigante, M, Zucchermaglio, C, Alby, F, Zulato, E, Montali, L, and Quagliarella, C

Subjects
Vegetative state, Social Representations, Positioning, Semi-structured interviews, Caregivers and practitioners
Abstract

The vegetative state is a condition in which a person is wakeful without being aware. To understand a patient who can be considered neither alive nor dead, caregivers and professionals re-define traditional identities, roles, and practices. By drawing on wider research, in the current chapter, we aimed to show how caregivers and practitioners positioned the patient and themselves within the institutional context of five nursing homes in Lombardy. We conducted 65 semi-structured interviews with 35 caregivers (sons, partners, parents) and 30 professionals (health, mental health professionals, and social workers). Our discourse analysis identified three different interpretative repertoires to position the patient: an organic, an interactional, and a possibilistic one. Their encounter both leads to disagreement and convergence. In particular, by taking each other’s perspective, professionals and caregivers might converge toward the common ground of balanced hope, where the possibility for patients’ awareness is neither fostered nor denied. In this space of possibilities, caregivers find a justification for their monitoring and patient stimulation activity and take on the role of spokesperson for the patient. This common ground allows them to communicate, justify their reciprocal action and acknowledge their roles and expertise in taking care of the patient.

Published
2023

47. Updated Analysis on the Outcomes of Children with Acute Leukemia (AL) Receiving an Alpha/Beta T and B-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (TBdepl-haploHSCT)

Author

Pietro Merli, Mattia Algeri, Federica Galaverna, Francesco Quagliarella, Valentina Bertaina, Elia Girolami, Antonella Meschini, Giovanna Del Principe, Simone Biagini, Raffaella Sborgia, Barbarella Lucarelli, Daria Pagliara, Marialuigia Catanoso, Chiara Rosignoli, Matilde Cossutta, Francesca Lanzaro, Costanza Canino, Maria Giuseppina Cefalo, Luisa Strocchio, Emilia Boccieri, Marco Becilli, Roberto Carta, Francesca Del Bufalo, Giuseppina Li Pira, and Franco Locatelli

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

48. Human leukocyte antigen evolutionary divergence influences outcomes of paediatric patients and young adults affected by malignant disorders given allogeneic haematopoietic stem cell transplantation from unrelated donors

Author

Merli, P., Crivello, P., Strocchio, L., Pinto, R. M., Algeri, M., Del Bufalo, F., Pagliara, D., Becilli, M., Carta, R., Gaspari, S., Galaverna, F., Quagliarella, F., Boz, G., Catanoso, M. L., Boccieri, E., Troiano, M., Fleischhauer, K., Andreani, M., Locatelli, Franco, Locatelli F. (ORCID:0000-0002-7976-3654), Merli, P., Crivello, P., Strocchio, L., Pinto, R. M., Algeri, M., Del Bufalo, F., Pagliara, D., Becilli, M., Carta, R., Gaspari, S., Galaverna, F., Quagliarella, F., Boz, G., Catanoso, M. L., Boccieri, E., Troiano, M., Fleischhauer, K., Andreani, M., Locatelli, Franco, and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

High genetic heterogeneity in the human leukocyte antigen (HLA) increases the likelihood of efficient immune response to pathogens and tumours. As measure of HLA diversity, HLA evolutionary divergence (HED) has been shown to predict the response of tumours to immunotherapy and haematopoietic stem cell transplantation (HSCT) in adults. We retrospectively investigated the association of HED with outcomes of 153 paediatric/young adults patients, treated for malignant disorders with HSCT from 9–10/10 HLA-matched unrelated donors. HED was calculated as pairwise genetic distance between alleles in patient HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1, using the locus median to stratify patients with ‘high’ or ‘low’ HED. Patients with high HED-B and -DRB1 showed significantly improved disease-free survival (DFS), especially when combined (70.8% vs 53.7% p = 0.008). High HED-B + -DRB1 was also associated with improved overall survival (OS) (82.1 vs 66.4% p = 0.014), and concomitant reduction of non-relapse-mortality (5.1% vs 21.1% p = 0.006). The impact on OS and DFS of combined HED-B + -DRB1 was confirmed in multivariate analysis [hazard ratio (HR) 0.39, p = 0.009; and HR 0.45, p = 0.007 respectively]. Only high HED scores for HLA-DPB1 were associated, in univariate analysis, with reduced incidence of relapse (15.9% vs 31.1%, p = 0.03). These results support HED as prognostic marker in allogeneic HSCT and, if confirmed in larger cohorts, would allow its use to inform clinical risk and potentially influence clinical practice.

Published
2023

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