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20 results on '"Quaas, Elisa"'

4. Esterase-Responsive Polyglycerol-Based Nanogels for Intracellular Drug Delivery in Rare Gastrointestinal Stromal Tumors

Author

Schötz, Sebastian, primary, Griepe, Adele K., additional, Goerisch, Björn B., additional, Kortam, Sally, additional, Vainer, Yael Shammai, additional, Dimde, Mathias, additional, Koeppe, Hanna, additional, Wedepohl, Stefanie, additional, Quaas, Elisa, additional, Achazi, Katharina, additional, Schroeder, Avi, additional, and Haag, Rainer, additional

Published
2023
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14. SARS‐CoV‐2 Inhibitors: Graphene Sheets with Defined Dual Functionalities for the Strong SARS‐CoV‐2 Interactions (Small 11/2021)

Author

Donskyi, Ievgen S., primary, Nie, Chuanxiong, additional, Ludwig, Kai, additional, Trimpert, Jakob, additional, Ahmed, Rameez, additional, Quaas, Elisa, additional, Achazi, Katharina, additional, Radnik, Jörg, additional, Adeli, Mohsen, additional, Haag, Rainer, additional, and Osterrieder, Klaus, additional

Published
2021
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18. Hyperbranched Polyglycerol Loaded with (Zinc-)Porphyrins: Photosensitizer Release Under Reductive and Acidic Conditions for Improved Photodynamic Therapy

Author

Staegemann, Michael H., Gräfe, Susanna, Gitter, Burkhard, Achazi, Katharina, Quaas, Elisa, Haag, Rainer, and Wiehe, Arno

Abstract

An adaptable approach toward cleavable nanoparticle carrier systems for photodynamic therapy (PDT) is presented, comprising a biocompatible carrier loaded with multiple photosensitizer (PS) molecules related to the clinically employed PS Temoporfin, two linkers cleavable under different triggers and glyco-targeting with mannose. A synthetic pathway to stimuli responsive hyperbranched polyglycerol (hPG) porphyrin conjugates via the copper(I)-catalyzed 1,3-dipolar cycloaddition (CuAAC) or the strain-promoted alkyne–azide cycloaddition (SPAAC) has been developed. The PS 10,15,20-tris(3-hydroxyphenyl)-5-(2,3,4,5,6-pentafluorophenyl)porphyrin was functionalized with disulfide containing cystamine and acid-labile benzacetal linkers. Conjugates with reductively and pH labile linkers were thus obtained. Cleavage of the active PS agents from the polymer carrier is shown in several different release studies. The uptake of the conjugates into the cells is demonstrated via confocal laser scanning microscopy (CLSM) and flow cytometry. Finally, the antitumor and antibacterial phototoxicity of selected conjugates has been assessed in four different tumor cell lines and in cultures of the bacterium Staphylococcus aureus. The conjugates exhibited phototoxicity in several tumor cell lines in which conjugates with reductively cleavable linkers were more efficient compared to conjugates with acid-cleavable linkers. For S. aureus, strong phototoxicity was observed for a combination of the reductively cleavable and the pH labile linker and likewise for the cleavable conjugate with mannose targeting groups. The results thus suggest that the conjugates have potential for antitumor as well as antibacterial PDT.

Published
2024
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19. Polyglycerol-Shelled Reduction-Sensitive Polymersome for DM1 Delivery to HER-2-Positive Breast Cancer

Author

Ma, Guoxin, Braatz, Daniel, Tang, Peng, Yang, Yian, Quaas, Elisa, Ludwig, Kai, Ma, Nan, Sun, Huanli, Zhong, Zhiyuan, and Haag, Rainer

Abstract

Supramolecular delivery systems with the prolonged circulation, the potential for diverse functionalization, and few toxin-related limitations have been extensively studied. For the present study, we constructed a linear polyglycerol-shelled polymersome attached with the anti-HER-2-antibody trastuzumab. We then covalently loaded the anticancer drug DM1 in the polymersome via dynamic disulfide bonding. The resulted trastuzumab-polymersome-DM1 (Tra-PS-DM1) exhibits a mean size of 95.3 nm and remarkable drug loading efficiency % of 99.3%. In addition to its superior stability, we observed the rapid release of DM1 in a controlled manner under reductive conditions. Compared to the native polymersomes, Tra-PS-DM1 has shown greatly improved cellular uptake and significantly reduced IC50up to 17-fold among HER-2-positive cancer cells. Moreover, Tra-PS-DM1 demonstrated superb growth inhibition of HER-2-positive tumoroids; specifically, BT474 tumoroids shrunk up to 62% after 12 h treatment. With exceptional stability and targetability, the PG-shelled Tra-PS-DM1 appears as an attractive approach for HER-2-positive tumor treatment.

Published
2024
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