Search

Your search keyword '"Qu, Moyuan"' showing total 28 results
Start Over Author "Qu, Moyuan"
28 results on '"Qu, Moyuan"'

3. Combined Effects of Electric Stimulation and Microgrooves in Cardiac Tissue‐on‐a‐Chip for Drug Screening

Author

Ren, Li, Zhou, Xingwu, Nasiri, Rohollah, Fang, Jun, Jiang, Xing, Wang, Canran, Qu, Moyuan, Ling, Haonan, Chen, Yihang, Xue, Yumeng, Hartel, Martin C, Tebon, Peyton, Zhang, Shiming, Kim, Han‐Jun, Yuan, Xichen, Shamloo, Amir, Dokmeci, Mehmet Remzi, Li, Song, Khademhosseini, Ali, Ahadian, Samad, and Sun, Wujin

Subjects
Heart Disease, Cardiovascular, Biotechnology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, cardiotoxicity, drug screening, electric stimulation, heart-on-a-chip, microgrooves
Abstract

Animal models and traditional cell cultures are essential tools for drug development. However, these platforms can show striking discrepancies in efficacy and side effects when compared to human trials. These differences can lengthen the drug development process and even lead to drug withdrawal from the market. The establishment of preclinical drug screening platforms that have higher relevancy to physiological conditions is desirable to facilitate drug development. Here, a heart-on-a-chip platform, incorporating microgrooves and electrical pulse stimulations to recapitulate the well-aligned structure and synchronous beating of cardiomyocytes (CMs) for drug screening, is reported. Each chip is made with facile lithographic and laser-cutting processes that can be easily scaled up to high-throughput format. The maturation and phenotypic changes of CMs cultured on the heart-on-a-chip is validated and it can be treated with various drugs to evaluate cardiotoxicity and cardioprotective efficacy. The heart-on-a-chip can provide a high-throughput drug screening platform in preclinical drug development.

Published
2020

5. An ROS‐Scavenging Treg‐Recruiting Hydrogel Patch for Diabetic Wound Healing.

Author

Qu, Moyuan, Xu, Weizhe, Zhou, Xingwu, Tang, Fan, Chen, Qian, Zhang, Xia, Bai, Xiaofeng, Li, Zhiyong, Jiang, Xing, and Chen, Qianming

Subjects
*WOUND healing, *SKIN regeneration, *REGULATORY T cells, *HYDROGELS, *REACTIVE oxygen species, *HAIR follicles, *GROWTH factors
Abstract

Chronic inflammation and excessive reactive oxygen species (ROS) can impair diabetic wound healing. Regulatory T cells (Tregs) have emerged as a promising target to promote wound healing by regulating the immune system and supporting tissue repair through the secretion of growth factors and cytokines. However, an effective strategy for the on‐demand recruitment of Tregs for wound healing is still lacking. Here, an ROS‐scavenging Tregs‐recruiting hydrogel patch is developed for the sequential release of C─C motif chemokine 22 (CCL22) triggered by the ROS in the diabetic wound bed. The hydrogel patch is prepared by crosslinking the gelatin with ROS cleavable linker together with CCL22 (RSG‐CCL22). RSG‐CCL22 presented desirable physical properties suitable for skin regeneration purposes. In addition, the ROS scavenging feature of the RSG suppresses the differentiation of T helper 17 (Th17) cells and protects the recruited Tregs from apoptosis and oxidative stress, which maximizes their function in accelerating wound closure and promoting hair follicle regeneration in a diabetic full‐thickness skin defect mouse model. Therefore, the proposed approach provides a new therapeutic strategy for tissue regeneration and wound repair via effective recruitment of functional Tregs through ROS‐triggered on‐demand delivery. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Loss of PA28γ exacerbates imbalanced differentiation of bone marrow stromal cells during bone formation and bone healing in mice

Author

Chen, Qian, primary, Wu, ZuPing, additional, Shi, YuJie, additional, Li, ZaiYe, additional, Yang, JiaKang, additional, Qu, MoYuan, additional, Zhang, ShiYu, additional, Wang, Zheng, additional, Ji, Ning, additional, Li, Jing, additional, Shen, YingQiang, additional, Xie, Liang, additional, and Chen, Qianming, additional

Published
2024
Full Text
View/download PDF

8. A Shear-Thinning Biomaterial-Mediated Immune Checkpoint Blockade

Author

Wu, Qingzhi, primary, Qu, Moyuan, additional, Kim, Han-Jun, additional, Zhou, Xingwu, additional, Jiang, Xing, additional, Chen, Yi, additional, Zhu, Jixiang, additional, Ren, Li, additional, Wolter, Tyler, additional, Kang, Heemin, additional, Xu, Chun, additional, Gu, Zhen, additional, Sun, Wujin, additional, and Khademhosseini, Ali, additional

Published
2022
Full Text
View/download PDF

11. pH-Responsive doxorubicin delivery using shear-thinning biomaterials for localized melanoma treatment

Author

Lee, Junmin, primary, Wang, Yonggang, additional, Xue, Chengbin, additional, Chen, Yi, additional, Qu, Moyuan, additional, Thakor, Jai, additional, Zhou, Xingwu, additional, Barros, Natan Roberto, additional, Falcone, Natashya, additional, Young, Patric, additional, van den Dolder, Floor W., additional, Lee, KangJu, additional, Zhu, Yangzhi, additional, Cho, Hyun-Jong, additional, Sun, Wujin, additional, Zhao, Bo, additional, Ahadian, Samad, additional, Jucaud, Vadim, additional, Dokmeci, Mehmet R., additional, Khademhosseini, Ali, additional, and Kim, Han-Jun, additional

Published
2022
Full Text
View/download PDF

12. Cover Image

Author

Qu, Moyuan, primary, Liao, Xiaoling, additional, Jiang, Nan, additional, Sun, Wujin, additional, Xiao, Wenqian, additional, Zhou, Xingwu, additional, Khademhosseini, Ali, additional, Li, Bo, additional, and Zhu, Songsong, additional

Published
2021
Full Text
View/download PDF

13. Reconstructing the tumor architecture into organoids

Author

Luo, Zhimin, primary, Zhou, Xingwu, additional, Mandal, Kalpana, additional, He, Na, additional, Wennerberg, Wally, additional, Qu, Moyuan, additional, Jiang, Xing, additional, Sun, Wujin, additional, and Khademhosseini, Ali, additional

Published
2021
Full Text
View/download PDF

14. Multi‐Dimensional Printing for Bone Tissue Engineering

Author

Qu, Moyuan, primary, Wang, Canran, additional, Zhou, Xingwu, additional, Libanori, Alberto, additional, Jiang, Xing, additional, Xu, Weizhe, additional, Zhu, Songsong, additional, Chen, Qianming, additional, Sun, Wujin, additional, and Khademhosseini, Ali, additional

Published
2021
Full Text
View/download PDF

16. Cancer‐on‐a‐Chip for Modeling Immune Checkpoint Inhibitor and Tumor Interactions

Author

Jiang, Xing, primary, Ren, Li, additional, Tebon, Peyton, additional, Wang, Canran, additional, Zhou, Xingwu, additional, Qu, Moyuan, additional, Zhu, Jixiang, additional, Ling, Haonan, additional, Zhang, Shiming, additional, Xue, Yumeng, additional, Wu, Qingzhi, additional, Bandaru, Praveen, additional, Lee, Junmin, additional, Kim, Han‐Jun, additional, Ahadian, Samad, additional, Ashammakhi, Nureddin, additional, Dokmeci, Mehmet R., additional, Wu, Jinhui, additional, Gu, Zhen, additional, Sun, Wujin, additional, and Khademhosseini, Ali, additional

Published
2021
Full Text
View/download PDF

17. Engineering Antiviral Vaccines

Author

Zhou, Xingwu, primary, Jiang, Xing, additional, Qu, Moyuan, additional, Aninwene, George E., additional, Jucaud, Vadim, additional, Moon, James J., additional, Gu, Zhen, additional, Sun, Wujin, additional, and Khademhosseini, Ali, additional

Published
2020
Full Text
View/download PDF

18. Rhodamine Conjugated Gelatin Methacryloyl Nanoparticles for Stable Cell Imaging

Author

Xue, Yumeng, primary, Lee, Junmin, additional, Kim, Han-Jun, additional, Cho, Hyun-Jong, additional, Zhou, Xingwu, additional, Liu, Yaowen, additional, Tebon, Peyton, additional, Hoffman, Tyler, additional, Qu, Moyuan, additional, Ling, Haonan, additional, Jiang, Xing, additional, Li, Zhikang, additional, Zhang, Shiming, additional, Sun, Wujin, additional, Ahadian, Samad, additional, Dokmeci, Mehmet. R., additional, Lee, KangJu, additional, and Khademhosseini, Ali, additional

Published
2020
Full Text
View/download PDF

20. Biodegradable β ‐Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water‐Insoluble Drug

Author

Zhou, Xingwu, primary, Luo, Zhimin, additional, Baidya, Avijit, additional, Kim, Han‐jun, additional, Wang, Canran, additional, Jiang, Xing, additional, Qu, Moyuan, additional, Zhu, Jixiang, additional, Ren, Li, additional, Vajhadin, Fereshteh, additional, Tebon, Peyton, additional, Zhang, Niyuan, additional, Xue, Yumeng, additional, Feng, Yudi, additional, Xue, Chengbin, additional, Chen, Yi, additional, Lee, KangJu, additional, Lee, Junmin, additional, Zhang, Shiming, additional, Xu, Chun, additional, Ashammakhi, Nureddin, additional, Ahadian, Samad, additional, Dokmeci, Mehmet Remzi, additional, Gu, Zhen, additional, Sun, Wujin, additional, and Khademhosseini, Ali, additional

Published
2020
Full Text
View/download PDF

21. Microneedle Patches: Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid (Small 16/2020)

Author

Zhu, Jixiang, primary, Zhou, Xingwu, additional, Kim, Han‐Jun, additional, Qu, Moyuan, additional, Jiang, Xing, additional, Lee, KangJu, additional, Ren, Li, additional, Wu, Qingzhi, additional, Wang, Canran, additional, Zhu, Xunmin, additional, Tebon, Peyton, additional, Zhang, Shiming, additional, Lee, Junmin, additional, Ashammakhi, Nureddin, additional, Ahadian, Samad, additional, Dokmeci, Mehmet Remzi, additional, Gu, Zhen, additional, Sun, Wujin, additional, and Khademhosseini, Ali, additional

Published
2020
Full Text
View/download PDF

23. Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

Author

Zhu, Jixiang, primary, Zhou, Xingwu, additional, Kim, Han‐Jun, additional, Qu, Moyuan, additional, Jiang, Xing, additional, Lee, KangJu, additional, Ren, Li, additional, Wu, Qingzhi, additional, Wang, Canran, additional, Zhu, Xunmin, additional, Tebon, Peyton, additional, Zhang, Shiming, additional, Lee, Junmin, additional, Ashammakhi, Nureddin, additional, Ahadian, Samad, additional, Dokmeci, Mehmet Remzi, additional, Gu, Zhen, additional, Sun, Wujin, additional, and Khademhosseini, Ali, additional

Published
2020
Full Text
View/download PDF

24. Biodegradable microneedle patch for transdermal gene delivery

Author

Qu, Moyuan, primary, Kim, Han-Jun, additional, Zhou, Xingwu, additional, Wang, Canran, additional, Jiang, Xing, additional, Zhu, Jixiang, additional, Xue, Yumeng, additional, Tebon, Peyton, additional, Sarabi, Shima A., additional, Ahadian, Samad, additional, Dokmeci, Mehmet R., additional, Zhu, Songsong, additional, Gu, Zhen, additional, Sun, Wujin, additional, and Khademhosseini, Ali, additional

Published
2020
Full Text
View/download PDF

27. Fabrication of superparamagnetic nanofibrous poly(l‐lactic acid)/γ‐Fe2O3 microspheres for cell carriers.

Author

Qu, Moyuan, Xiao, Wenqian, Tian, Jiarong, Wang, Song, Li, Hong, Liu, Xue, Yang, Xiaoling, Li, Bo, and Liao, Xiaoling

Abstract

Nanofibrous poly(l‐lactic acid) (PLLA) microspheres are extensively studied to be used as cell carriers in the field of tissue engineering because the unique structure can promote cell proliferation and migration. But as injectable scaffold materials, PLLA microspheres easily run off to the soft tissue space because of the lack of cohesive force. It will affect the treatment efficiency and even cause additional inflammatory response. In order to overcome this disadvantage, superparamagnetic γ‐Fe2O3 nanoparticles assisted with oxidative polymerization of dopamine were used for surface modification of PLLA microspheres in this study. The results showed that this surface modification had no obvious cytotoxicity, and the modified microspheres possessed the ability to carry seed cells to controllably move to the defect sites with the guidance of magnetic field, which may be able to increase the repair efficiency. Moreover, the characteristic nanofibrous structure was not destroyed after modification, which was able to promote biological activity of cells. This work provides a novel way to produce superparamagnetic nanofibrous microspheres designed for cell microcarriers. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 511–520, 2019. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

28. Fabrication of superparamagnetic nanofibrous poly(l-lactic acid)/γ-Fe 2 O 3 microspheres for cell carriers.

Author

Qu M, Xiao W, Tian J, Wang S, Li H, Liu X, Yang X, Li B, and Liao X

Subjects
Cell Line, Tumor, Humans, Magnetic Fields, Cells, Immobilized cytology, Cells, Immobilized metabolism, Ferrosoferric Oxide chemistry, Microspheres, Nanofibers chemistry, Polyesters chemistry
Abstract

Nanofibrous poly(l-lactic acid) (PLLA) microspheres are extensively studied to be used as cell carriers in the field of tissue engineering because the unique structure can promote cell proliferation and migration. But as injectable scaffold materials, PLLA microspheres easily run off to the soft tissue space because of the lack of cohesive force. It will affect the treatment efficiency and even cause additional inflammatory response. In order to overcome this disadvantage, superparamagnetic γ-Fe 2 O 3 nanoparticles assisted with oxidative polymerization of dopamine were used for surface modification of PLLA microspheres in this study. The results showed that this surface modification had no obvious cytotoxicity, and the modified microspheres possessed the ability to carry seed cells to controllably move to the defect sites with the guidance of magnetic field, which may be able to increase the repair efficiency. Moreover, the characteristic nanofibrous structure was not destroyed after modification, which was able to promote biological activity of cells. This work provides a novel way to produce superparamagnetic nanofibrous microspheres designed for cell microcarriers. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 511-520, 2019., (© 2018 Wiley Periodicals, Inc.)

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results