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This article discusses the development and validation of a prognostic model for predicting flares in generalized pustular psoriasis (GPP). GPP is a rare auto-inflammatory skin disease characterized by recurrent flares of neutrophil-filled sterile pustules. These flares can have a significant impact on the daily activities and overall well-being of patients and can lead to life-threatening complications if left untreated. The study aimed to identify risk factors for GPP flare and construct a predictive model based on clinical characteristics to forecast the occurrence of flares. The model incorporates four features: history of psoriasis vulgaris, risky alcohol use, temperature at fever, and albumin levels. The model achieved promising results in internal and external validation processes and may provide critical insights into GPP flare patterns and help prevent such episodes. [Extracted from the article]

Generalized pustular psoriasis (GPP) is a rare and potentially life‐threatening skin disease and the clinical heterogeneity of which is largely unknown. Retrospective cohort analysis was conducted on hospitalized GPP patients between January 2010 and November 2022. A total of 416 patients with GPP and psoriasis vulgaris (PV) respectively were included, matched 1:1 by sex and age. The heterogeneity of GPP was stratified by PV history and age. Compared with PV, GPP was significantly associated with prolonged hospitalization (11.7 vs. 10.3 day, p < 0.001), elevated neutrophil lymphocyte ratio (NLR) (5.93 vs. 2.44, p < 0.001) and anemia (13.9% vs. 1.2%, p < 0.001). Moreover, GPP alone (without PV history) was a relatively severer subtype with higher temperature (37.6°C vs. 38.0°C, p = 0.002) and skin infections (5.2% vs. 11.4%, p = 0.019) than GPP with PV. For patients across different age, compared with juvenile patients, clinical features support a severer phenotype in middle‐aged, including higher incidence of anaemia (7.5% vs. 16.0%, p = 0.023) and NLR score (3.83 vs. 6.88, p < 0.001). Interleukin‐6 (r = 0.59), high density lipoprotein cholesterol (r = −0.56), albumin (r = −0.53) and C‐reactive protein‐to‐albumin ratio (r = 0.49) were the most relevant markers of severity in GPP alone, GPP with PV, juvenile and middle‐aged GPP, respectively. This retrospective cohort suggests that GPP is highly heterogeneous and GPP alone and middle‐aged GPP exhibit severe disease phenotypes. More attention on the heterogeneity of this severe disease is warranted to meet the unmet needs and promote the individualized management of GPP. [ABSTRACT FROM AUTHOR]

Background: Facial telangiectasia is one of the common skin vascular lesions characterized by dilated cutaneous vasculatures. The variety of diameters and difference in depths of lesional blood vessels are the major challenges for effective treatments for Facial telangiectasia. Aims: To compare the efficacy and safety profiles of pulsed dye laser (PDL, 595 nm) with intense pulsed light (IPL) configured by three different wavelength bands in the treatment for facial telangiectasia in Asian populations. Patients/Methods: A retrospective analysis of hospital records and review on photographs were performed for those subjects with facial telangiectasia (n = 160) who were treated in our department from January 2017 to January 2019. Patients were received two sessions of one of the four following laser treatments: PDL (595 nm, n = 38), IPL with M22 vascular filter (530‐650 nm and 900‐1200 nm, n = 39), M22 560 (560‐1200 nm, n = 42), and M22 590 (590‐1200 nm, n = 41). Results: The patients in all the four groups showed an overall and significant improvement of indexes of lesional severity and subjective discomfort as well as improvement score of facial telangiectasia after treatment as compared to baseline. In addition, PDL (595 nm) and IPL with vascular filter (530‐650 nm and 900‐1200 nm) treatments showed significantly better indexes of lesional severity, subjective discomfort, and improvement score of facial telangiectasia as compared with other two treatments. Conclusion: Light devices with various wavelength ranges showed different efficacies of treatment for facial telangiectasia, among which PDL (595 nm) and IPL with M22 vascular filter (530‐650 nm and 900‐1200 nm) had similar and the best clinical efficacy as compared to IPL with other wavelength bands. [ABSTRACT FROM AUTHOR]

To resolve conflicting results in the literature, we determine quantitatively the properties of the lowest triplet excited state of water soluble 2:1 host:guest complexes of C 60 embedded in γ-cyclodextrin (γ-CD/C 60 ) using laser flash photolysis. The results show that the triplet excited state characteristics of γ-CD/C 60 in aqueous solutions are very similar to those observed for C 60 in organic solvents. Moreover oxygen, in contrast with non-gaseous solutes, can reach the proximity of C 60 embedded in 2:1 γ-CD inclusion complexes. In addition, photodestruction quantum yields have been determined for C 60 in toluene and for C 60 in γ-CD inclusion complexes in water. [ABSTRACT FROM AUTHOR]

Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease that centers around the hair follicle and occurs as a result of follicular occlusion. HS primarily presents as painful, inflamed lesions that begin during puberty and occur most commonly in areas with numerous apocrine glands. The etiology and pathogenesis of HS involve internal and external factors, including genetic susceptibility, inflammation and immunity, microorganisms, obesity, and smoking. Management of HS is difficult, and the current aim of treatment is to control the frequency and duration of disease flare-ups and improve the quality of life. Medical treatments include antibiotics, retinoids, biologics, immunosuppressive agents, and antiandrogen agents. Adjuvant treatment includes surgery, laser, and light therapy. However, the efficacy of these treatment modalities varies from person to person. In recent years, related reports have shown that injection of botulinum toxin type A has a positive effect in the management of HS. This article reviews the pathogenesis, clinical manifestations, diagnosis, and traditional treatment methods for the management of HS and investigates the use of botulinum toxin type A as a treatment option for this disease., Competing Interests: None., (AJTR Copyright © 2021.)