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1. Performance and effectiveness of hepatocellular carcinoma screening in individuals with HBsAg seropositivity in China: a multicenter prospective study

Author

Zeng, Hongmei, Cao, Maomao, Xia, Changfa, Wang, Dongmei, Chen, Kun, Zhu, Zheng, Fu, Ruiying, Zhang, Shaokai, Zhou, Jinyi, Wang, Huadong, Qi, Xianyun, Dai, Shuguang, Chen, Yong, Sun, Zhong, Ding, Hao, Li, Qingwen, Zhao, Hui, Zhang, Xuehong, Morze, Jakub, Ji, John S., Sun, Feng, Yu, Xueqin, Qu, Chunfeng, and Chen, Wanqing

Published
2023
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6. Publisher Correction: Performance and effectiveness of hepatocellular carcinoma screening in individuals with HBsAg seropositivity in China: a multicenter prospective study

Author

Zeng, Hongmei, Cao, Maomao, Xia, Changfa, Wang, Dongmei, Chen, Kun, Zhu, Zheng, Fu, Ruiying, Zhang, Shaokai, Zhou, Jinyi, Wang, Huadong, Qi, Xianyun, Dai, Shuguang, Chen, Yong, Sun, Zhong, Ding, Hao, Li, Qingwen, Zhao, Hui, Zhang, Xuehong, Morze, Jakub, Ji, John S., Sun, Feng, Yu, Xueqin, Qu, Chunfeng, and Chen, Wanqing

Published
2023
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7. Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy

Author

Qu, Chunfeng, Wang, Yuting, Wang, Pei, Chen, Kun, Wang, Minjie, Zeng, Hongmei, Lu, Jianquan, Song, Qianqian, Diplas, Bill H, Tan, Da, Fan, Chunsun, Guo, Qigao, Zhu, Zheng, Yin, Huihui, Jiang, Liping, Chen, Xixi, Zhao, Hui, He, Huan, Wang, Yong, Li, Guangyu, Bi, Xinyu, Zhao, Xinming, Chen, Taoyang, Tang, Hongping, Lv, Chuanguo, Wang, Dongmei, Chen, Wanqing, Zhou, Jianguo, Zhao, Hong, Cai, Jianqiang, Wang, Xiaoyue, Wang, Sizhen, Yan, Hai, Zeng, Yi-Xin, Cavenee, Webster K, and Jiao, Yuchen

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Liver Cancer, Liver Disease, Chronic Liver Disease and Cirrhosis, Hepatitis, Prevention, Digestive Diseases, Rare Diseases, Emerging Infectious Diseases, Clinical Research, Infectious Diseases, Cancer, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Good Health and Well Being, Biomarkers, Tumor, Carcinoma, Hepatocellular, Cell-Free Nucleic Acids, Early Detection of Cancer, Hepatitis B Surface Antigens, Hepatitis B virus, Hepatitis B, Chronic, Humans, Liquid Biopsy, Liver Neoplasms, Sensitivity and Specificity, Ultrasonography, cell free DNA, hepatocellular carcinoma, early detection of cancer, HBsAg-seropositive
Abstract

Liquid biopsies, based on cell free DNA (cfDNA) and proteins, have shown the potential to detect early stage cancers of diverse tissue types. However, most of these studies were retrospective, using individuals previously diagnosed with cancer as cases and healthy individuals as controls. Here, we developed a liquid biopsy assay, named the hepatocellular carcinoma screen (HCCscreen), to identify HCC from the surface antigen of hepatitis B virus (HBsAg) positive asymptomatic individuals in the community population. The training cohort consisted of individuals who had liver nodules and/or elevated serum α-fetoprotein (AFP) levels, and the assay robustly separated those with HCC from those who were non-HCC with a sensitivity of 85% and a specificity of 93%. We further applied this assay to 331 individuals with normal liver ultrasonography and serum AFP levels. A total of 24 positive cases were identified, and a clinical follow-up for 6-8 mo confirmed four had developed HCC. No HCC cases were diagnosed from the 307 test-negative individuals in the follow-up during the same timescale. Thus, the assay showed 100% sensitivity, 94% specificity, and 17% positive predictive value in the validation cohort. Notably, each of the four HCC cases was at the early stage (

Published
2019

11. HBV integrations reshaping genomic structures promote hepatocellular carcinoma

Author

Qian, Zhaoyang, primary, Liang, Junbo, additional, Huang, Rong, additional, Song, Wei, additional, Ying, Jianming, additional, Bi, Xinyu, additional, Zhao, Jianjun, additional, Shi, Zhenyu, additional, Liu, Wenjie, additional, Liu, Jianmei, additional, Li, Zhiyu, additional, Zhou, Jianguo, additional, Huang, Zhen, additional, Zhang, Yefan, additional, Zhao, Dongbing, additional, Wu, Jianxiong, additional, Wang, Liming, additional, Chen, Xiao, additional, Mao, Rui, additional, Zhou, Yanchi, additional, Guo, Lei, additional, Hu, Hanjie, additional, Ge, Dazhuang, additional, Li, Xingchen, additional, Luo, Zhiwen, additional, Yao, Jinjie, additional, Li, Tengyan, additional, Chen, Qichen, additional, Wang, Bingzhi, additional, Wei, Zhewen, additional, Chen, Kun, additional, Qu, Chunfeng, additional, Cai, Jianqiang, additional, Jiao, Yuchen, additional, Bao, Li, additional, and Zhao, Hong, additional

Published
2024
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19. Supplementary Data from XCL1/Glypican-3 Fusion Gene Immunization Generates Potent Antitumor Cellular Immunity and Enhances Anti–PD-1 Efficacy

Author

Chen, Kun, primary, Wu, Zhiyuan, primary, Zhao, Hong, primary, Wang, Yanmei, primary, Ge, Yutong, primary, Wang, Dongmei, primary, Li, Zhengjiang, primary, An, Changming, primary, Liu, Yuying, primary, Wang, Feifei, primary, Bi, Xinyu, primary, Wang, Hongying, primary, Cai, Jianqiang, primary, Ma, Chunhong, primary, and Qu, Chunfeng, primary

Published
2023
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20. Data from XCL1/Glypican-3 Fusion Gene Immunization Generates Potent Antitumor Cellular Immunity and Enhances Anti–PD-1 Efficacy

Author

Chen, Kun, primary, Wu, Zhiyuan, primary, Zhao, Hong, primary, Wang, Yanmei, primary, Ge, Yutong, primary, Wang, Dongmei, primary, Li, Zhengjiang, primary, An, Changming, primary, Liu, Yuying, primary, Wang, Feifei, primary, Bi, Xinyu, primary, Wang, Hongying, primary, Cai, Jianqiang, primary, Ma, Chunhong, primary, and Qu, Chunfeng, primary

Published
2023
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22. Role of CCR8 and Other Chemokine Pathways in the Migration of Monocyte-derived Dendritic Cells to Lymph Nodes

Author

Qu, Chunfeng, Edwards, Emmerson W, Tacke, Frank, Angeli, Véronique, Llodrá, Jaime, Sanchez-Schmitz, Guzman, Garin, Alexandre, Haque, Nasreen S, Peters, Wendy, van Rooijen, Nico, Sanchez-Torres, Carmen, Bromberg, Jonathan, Charo, Israel F, Jung, Steffen, Lira, Sergio A, and Randolph, Gwendalyn J

Subjects
Biomedical and Clinical Sciences, Emerging Infectious Diseases, Animals, Cell Movement, Cytokines, DNA Primers, Dendritic Cells, Flow Cytometry, Humans, Immunoblotting, Lymph Nodes, Mice, Mice, Inbred C57BL, Microspheres, Monocytes, Receptors, CCR7, Receptors, CCR8, Receptors, Chemokine, Reverse Transcriptase Polymerase Chain Reaction, Skin, chemotaxis, endothelium, inflammation, lymphatic system, macrophage, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

Studying the influence of chemokine receptors (CCRs) on monocyte fate may reveal information about which subpopulations of monocytes convert to dendritic cells (DCs) and the migration pathways that they use. First, we examined whether prominent CCRs on different monocyte subsets, CCR2 or CX3CR1, mediated migration events upstream of the accumulation of monocyte-derived DCs in lymph nodes (LNs). Monocytes were labeled and traced by uptake of latex microspheres in skin. Unexpectedly, neither CCR2 nor CX3CR1 were required. However, absence of CCR2 led to an increased labeling of the minor Gr-1int monocyte population, and the number of latex+ DCs that emigrated to LNs was correspondingly increased. Characterization of Gr-1int monocytes revealed that they selectively expressed CCR7 and CCR8 mRNA in blood. CCR7 and CCR8 pathways were used by monocyte-derived DCs during mobilization from skin to LNs. The role of CCR8 in emigration from tissues also applied to human monocyte-derived cells in a model of transendothelial trafficking. Collectively, the data suggest that Gr-1int monocytes may be most disposed to become a lymphatic-migrating DCs. When these monocyte-derived DCs exit skin to emigrate to LNs, they use not only CCR7 but also CCR8, which was not previously recognized to participate in migration to LNs.

Published
2004

24. Abnormal generation of IL-17A represses tumor infiltration of stem-like exhausted CD8+ T cells to demote the antitumor immunity.

Author

Zhang, Ruochan, Chen, Kun, Gong, Caifeng, Wu, Zhiyuan, Xu, Chungui, Li, Xing-Ning, Zhao, Fei, Wang, Dongmei, Cai, Jianqiang, Zhou, Aiping, and Qu, Chunfeng

Subjects
T cells, CYTOTOXIC T cells, VASCULAR endothelial growth factors, VASCULAR endothelium, IMMUNE checkpoint proteins
Abstract

Background: Variated anti-cancer therapies are combined with immune checkpoint blockades (ICBs) for improving ICB therapeutic efficacy. Occurrence of tissue damage is common that triggers multiple inflammatory cytokine generation. Gastrointestinal organs are the commonly affected. We investigated the impact of acute colitis on tumor infiltration of antigen-specific CD8+ cytotoxic T lymphocytes (CTLs) for controlling tumor growth and responding to antibody against PD-1 (anti-PD-1). Methods: Several tumor cell lines were inoculated into syngeneic mice subcutaneously or intra-hepatically. When tumor mass formed, activated CTLs were intravenously transferred into the tumor-bearing mice, that were given the drinking water containing 2% dextran sulfate sodium (DSS) for acute colitis induction. Tumor growth, infiltration of two exhausted CTL subsets, and the CTL interaction with tumor vascular endothelium were examined. Results: Acute colitis dampened CTL-mediated antitumor effects, correlating with IL-17A elevation in the inflamed intestine. In the tumor bed, stem-like exhausted CTLs, which were defined as PD-1+Slamf6+Tim3−, expressed higher IL-17A receptor heterodimers and lower leukocyte function-associated antigen-1 (LFA-1) than terminally exhausted CTLs did, that were defined as PD-1+Slamf6−Tim3+. IL-17A stimulation reduced LFA-1 surface expression on stem-like exhausted CTLs and the counterpart ICAM-1 (intracellular adhesion molecule-1) on tumor vascular endothelium. IL-17A stimulation suppressed the extravasation across tumor vascular endothelium and self-renewal of stem-like, not the terminally exhausted CTLs. Administration of anti-IL-17A neutralizing antibody to the colitis mice restored the CTL tumor infiltration and enhanced anti-PD-1 treatment efficacy against tumors. In 33 hepatocellular carcinoma patients being treated with anti-PD-1 plus antibody against vascular endothelial growth factor, disease progression of 15 patients, that exhibited serum IL-17A increase 24 h post-therapy as compared to pre-therapy level, was poorer than that of 18 patients that exhibited serum IL-17A no-increase. Conclusions: Abnormal generation of IL-17A mainly repressed tumor infiltration of stem-like exhausted CTLs. ICB-based immunotherapeutic efficacy could be upgraded with administration of anti-IL-17A, when treatment-related IL-17A elevation occurred due to tissue damage, such as acute colitis. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Simultaneous analysis of mutations and methylations in circulating cell-free DNA for hepatocellular carcinoma detection

Author

Wang, Pei, primary, Song, Qianqian, additional, Ren, Jie, additional, Zhang, Weilong, additional, Wang, Yuting, additional, Zhou, Lin, additional, Wang, Dongmei, additional, Chen, Kun, additional, Jiang, Liping, additional, Zhang, Bochao, additional, Chen, Wanqing, additional, Qu, Chunfeng, additional, Zhao, Hong, additional, and Jiao, Yuchen, additional

Published
2022
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29. Epidemiological Characteristics of Primary Liver Cancer in Mainland China From 2003 to 2020: A Representative Multicenter Study

Author

Lin, Jiansheng, primary, Zhang, Hongwei, additional, Yu, Hongping, additional, Bi, Xinyu, additional, Zhang, Weilu, additional, Yin, Jianhua, additional, Zhao, Pei, additional, Liang, Xiumei, additional, Qu, Chunfeng, additional, Wang, Minjie, additional, Hu, Ming, additional, Liu, Kun, additional, Wang, Yuting, additional, Zhou, Zihan, additional, Wang, Junqi, additional, Tan, Xiaojie, additional, Liu, Wenbin, additional, Shao, Zhongjun, additional, Cai, Jianqiang, additional, Tang, Weizhong, additional, and Cao, Guangwen, additional

Published
2022
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30. Long term outcome of prevention of liver cancer by hepatitis B vaccine: Results from an RCT with 37 years

Author

Cao, Maomao, primary, Fan, Jian, additional, Lu, Lingling, additional, Fan, Chunsun, additional, Wang, Yuting, additional, Chen, Taoyang, additional, Zhang, Shaoli, additional, Yu, Yiwen, additional, Xia, Changfa, additional, Lu, Jianhua, additional, Chen, Kun, additional, Yao, Hongyu, additional, Chen, Wanqing, additional, and Qu, Chunfeng, additional

Published
2022
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31. Additional file 1 of The population-level economic burden of liver cancer in China, 2019–2030: prevalence-based estimations from a societal perspective

Author

Cao, Meng-Di, Liu, Cheng-Cheng, Wang, Hong, Lei, Lin, Cao, Maomao, Wang, Yuting, Li, He, Yan, Xin-Xin, Li, Yan-Jie, Wang, Xin, Peng, Ji, Qu, Chunfeng, Feletto, Eleonora, Shi, Ju-Fang, and Chen, Wanqing

Abstract

Additional file 1: Table S1. Inputting parameters of disease burden of liver cancer in China, 2019. Table S2. Inputting parameters of survival probability, employment rates and numbers population in China. Table S3. Annual direct medical, non-medical expenditure and work-loss days per liver cancer patient in China in 2019 by year post-diagnosis.

Published
2022
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32. Additional file 1 of Occult infection with hepatitis B virus PreS variants synergistically promotes hepatocellular carcinoma development in a high-fat diet context by generating abnormal ceramides

Author

Liu, Chang, Chen, Kun, Zhao, Fei, Xuan, Lingling, Wang, Yuting, Xu, Chungui, Wu, Zhiyuan, Wang, Dongmei, and Qu, Chunfeng

Abstract

Additional file 1: Supplementary Methods. Tables S1. Primers used for detection of HBV cccDNA, amplification and sequencing of PreS/S regions. Tables S2. Antibodies and ELISA kits. Tables S3. Primers used in qRT-PCR analysis. Tables S4. Histology-confirmed 1823 HCC patients with different serologically viral markers. Tables S5. The amounts of specified ceramide species determined by HPLC-MS/MS in HepG2 cells that were differently treated for 24 h after HBV plasmid transfection. Fig. S1. Analysis of HBV PreS/S regions in 35 HCC patients with serological markers of HBsAg(-) & anti-HBc(+) & anti-HCV(-). Fig. S2. Aliment of 35 HBV isolates from the HBsAg-seronegative HCC patients. Fig. S3. Profile of the HBV replicating plasmids. Fig. S4. The staining of envelop proteins and hepatocyte ER in five independent experiments. Fig. S5. HBsAg secretion from hepatocytes after transfection with different HBV plasmids. Fig. S6. Transcriptional levels of IRE1α, ATF6, and PERK in HepG2 cells after transfection with different HBV plasmids. Fig. S7. Transcriptional levels of CERS1-6 and DEGS1. Fig. S8. Schematic diagram of culture system to examine the effects of ceramides from hepatocytes that were transfected with different HBV plasmids on inflammatory macrophages. Fig. S9. Serum levels of HBsAg in mice that were injected with different HBV plasmids. Fig. S10. Body weight and liver weight of the mice fed different diet types. Fig. S11. Representative histological images of the DEN-treated mice livers with different diet types. Fig. S12. Transcriptional levels of CerS1-6 and Degs1 genes in mice livers. Fig. S13. Liver macroscopic appearance and tumour numbers in the DEN-treated mice with different diet types. Fig. S14. Liver weight and H&E staining of mice livers without DEN injection. Fig. S15. Graphic abstract.

Published
2022
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38. A Male-ABCD Algorithm for Hepatocellular Carcinoma Risk Prediction in HBsAg Carriers

Author

Wang, Yuting, primary, Wang, Minjie, additional, Li, He, additional, Chen, Kun, additional, Zeng, Hongmei, additional, Bi, Xinyu, additional, Zhu, Zheng, additional, Jiao, Yuchen, additional, Wang, Yong, additional, Zhu, Jian, additional, Zhao, Hui, additional, Liu, Xiang, additional, Dai, Chunyun, additional, Fan, Chunsun, additional, Zhao, Can, additional, Guo, Deyin, additional, Zhao, Hong, additional, Wang, Sizhen, additional, Zhou, Jianguo, additional, Wang, Dongmei, additional, Wu, Zhiyuan, additional, Zhao, Xinming, additional, Cui, Wei, additional, Zhang, Xuehong, additional, Cai, Jianqiang, additional, Chen, Wanqing, additional, and Qu, Chunfeng, additional

Published
2021
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42. Medical expenditure for liver cancer in urban China: A 10-year multicenter retrospective survey (2002-2011)

Author

Qiu, Wu-Qi, Shi, Ju-Fang, Guo, Lan-Wei, Mao, A-Yan, Huang, Hui-Yao, Hu, Guang-Yu, Dong, Pei, Bai, Fang-Zhou, Yan, Xiao-Ling, Liao, Xian-Zhen, Liu, Guo-Xiang, Bai, Ya-Na, Ren, Jian-Song, Sun, Xiao-Jie, Zhu, Xin-Yu, Zhou, Jin-Yi, Gong, Ji-Yong, Zhu, Lin, Mai, Ling, Du, Ling-Bing, Zhou, Qi, Xing, Xiao-Jing, Song, Bing-Bing, Liu, Yu-Qin, Lou, Pei-An, Sun, Xiao-Hua, Wu, Shou-Ling, Cao, Rong, Qi, Xiao, Lan, Li, Ren, Ying, Zhang, Kai, He, Jie, Qu, Chunfeng, and Dai, Min

Subjects
Liver cancer -- Surveys -- Care and treatment -- Diagnosis, Medical records -- Usage, Health
Abstract

Byline: Wu-Qi. Qiu, Ju-Fang. Shi, Lan-Wei. Guo, A-Yan. Mao, Hui-Yao. Huang, Guang-Yu. Hu, Pei. Dong, Fang-Zhou. Bai, Xiao-Ling. Yan, Xian-Zhen. Liao, Guo-Xiang. Liu, Ya-Na. Bai, Jian-Song. Ren, Xiao-Jie. Sun, Xin-Yu. [...]

Published
2018

44. Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China

Author

Sun, Zongtang, Chen, Taoyang, Thorgeirsson, Snorri S., Zhan, Qimin, Chen, Jianguo, Park, Ju-Hyun, Lu, Peixin, Hsia, Chu Chieh, Wang, Nengjin, Xu, Libin, Lu, Lingling, Huang, Fei, Zhu, Yuanrong, Lu, Jianhua, Ni, Zhengping, Zhang, Qinan, Wu, Yuying, Liu, Guoting, Wu, Zhiyuan, Qu, Chunfeng, and Gail, Mitchell H.

Published
2013
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48. XCL1/Glypican-3 Fusion Gene Immunization Generates Potent Antitumor Cellular Immunity and Enhances Anti–PD-1 Efficacy

Author

Chen, Kun, primary, Wu, Zhiyuan, additional, Zhao, Hong, additional, Wang, Yanmei, additional, Ge, Yutong, additional, Wang, Dongmei, additional, Li, Zhengjiang, additional, An, Changming, additional, Liu, Yuying, additional, Wang, Feifei, additional, Bi, Xinyu, additional, Wang, Hongying, additional, Cai, Jianqiang, additional, Ma, Chunhong, additional, and Qu, Chunfeng, additional

Published
2020
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