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Background: Disruption to healing process results on longer healing duration from the timeline. Povidone iodine and tulle are common management in wound care. The advance of industry in health sector and the availability of natural ingredients in Indonesia provide opportunities for developing alternatives for wound care. Turmeric (Curcuma longa) contains curcumin which is anti-inflammatory, antibacterial, and antioxidant; it is good for wound healing. Hydrogel nanocomplexes of carboxymethyl chitosan can maintain moisture in wound area and protect curcumin from hydrolysis. Objective: To analyze the potential of turmeric extract loaded hidrogels in accelerating wound closur. Method: experimental research with "post-test only control group design". The sample consisted of 30 mice which were assigned into 5 groups. Result: All experimental groups experienced a gradual decrease in wound length. The statistical test results for groups II and III showed significant advantages compared to group IV (p<0.05). Meanwhile, group I did not have significant differences in wound closure compared to group IV on day 1 and 3 (p>0.05), but it had significant results (p<0.05) on day 5. Conclusion: Turmeric extract loaded hidrogels can accelerate the reduction of wound length. [ABSTRACT FROM AUTHOR]

Background: Osteoarthritis (OA) is one of the most common disease occur in elderly. It is commonly occurs in knee, hips and interphalangeal joints Pain caused by knee OA may result in functional disorders that affect patient’s life quality.Objective: To analyze correlation of quadriceps and hamstring muscles strength with knee OA stages and pain levels in elderly female subjects.Methods: 38 elderly female subjects (average age of 67.18 ± 4.91) were assessed for pain scale using numeric rating scale (NRS). We used 1RM protocol (EN-Tree) to measure quadriceps and hamstring muscles strength. We performed anterior-posterior and lateral knee X-rays to determine OA stage. The process of data analysis was conducted using several tests, including Kolmogorov-Smirnov test, Pearson’s correlation test, Spearman’s correlation test and Mann-Whitney test to measure difference between knee OA level using 1RM quadriceps muscle and quadriceps/hamstring (Q/H) ratio.Results: The average NRS was 3.68 ± 1.19, 1RM quadriceps and hamstring muscles strength were 2.68 ± 1.23 and 1.11 ± 0.44, respectively, quadricep/hamstring ratio (Q/H) was 2.53 ± 0.95. A total of 30 subjects had OA stage 2, while 8 subjects had OA stage 3.Conclusion: The 1RM quadriceps and hamstring muscles was not correlated with NRS. There was no difference in 1RM quadriceps and hamstring muscles between subjects with OA stage 2 and 3. We found a positive correlation between Q/H ratio and the NRS. The Q/H ratio in subjects with OA level 2and 3 was different. [ABSTRACT FROM AUTHOR]

Background & Objectives: Treatment of chronic pain using NSAIDs, steroids, opioids, and herbs has been associated with many complications with the long-term use. Wet cupping therapy (WCT) has been used to reduce pain, by triggering mu opioid receptor expression. We conducted this study to compare the effectiveness between WCT with oral opioids for pain management. Methodology: It was an experimental study with randomized control group post-test only design. Thirty two male white rats of strain Wistar were divided into four groups: (1) Group-NC; mice in this group were given nothing as a negative control group, (2) Group-CFA; group that was given Complete Freund’s Adjuvant (CFA) only as a positive control group, (3) Group-WCT; mice were given CFA and WCT, and (4) Group-O was given CFA and oral opioids. The measured variables were pain threshold value and mu opioid receptors. Statistical analysis was done us(ing SPSS software (version 22.0, Chicago, IL). Results: The results showed no significant differences in the expression of mu opioid receptors between Group-NC and Group-CFA (p = 0.061). There were significant differences in the expression of opioid receptors between Group-CFA and Group-WCT (p < 0.001), and also between WCT group and Group-O (p = 0.002). The differences of pain threshold value were only significant between Group-NC (p = 0,006) and Group-CFA (p = 0,013) with Group-O. Conclusion: Wet cupping therapy triggers the expression of mu opioid receptors. Wet cupping therapy as effective in relieving pain as opioids. [ABSTRACT FROM AUTHOR]