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Zhenzhen Liu, Mingxi Shao, Jun Ren, Yichao Qiu, Shengjie Li, Wenjun Cao Department of Clinical Laboratory, Eye and Ear Nose Throat (ENT) Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Shengjie Li; Wenjun Cao, Department of Clinical Laboratory, Eye and Ear Nose Throat (ENT) Hospital, Shanghai Medical College, Fudan University, Fenyang Road 83th, Shanghai, People’s Republic of China, Tel/Fax +86 21-64377134-2510 ; +86 21-64377134-2662, Email lishengjie6363020@163.com; wgkjyk@aliyun.comPurpose: We aimed to investigate the association between lipid profiles and diabetic retinopathy (DR).Patients and Methods: This case-control study, which was conducted between November 2019 and August 2021, comprised 309 patients with DR, 186 patients with diabetes mellitus, and 172 healthy controls. Serum cholesterol (CHOL), triglyceride (TRIG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (SDLDL-C), apolipoprotein A (APOA), APOB, APOE and lipoprotein (a)(LPA) levels were assessed. Patients were divided into two groups according to median age and glycated hemoglobin (HbA1c) level. Linear and logistic regression analyses were performed to assess the association between lipid levels and DR.Results: CHOL, TRIG, HDL-C, APOB, APOE, and SDLDL-C levels were significantly higher in the DR group than in the healthy control group, and TRIG levels were lower in the DR group than in the DM group (P < 0.05), especially in the ≤ 57-year-old and the HbA1c ≤ 7.2% subgroups. Linear regression analyses showed that CHOL, TRIG, APOA, APOB, APOE, and SDLDL-C levels were associated with HbA1c levels. Multivariable logistic regression analyses indicated that CHOL (odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.112– 1.566), TRIG (OR = 1.269, 95% CI = 1.030– 1.563), HDL-C (OR = 43.744, 95% CI = 17.12– 111.769), APOB (OR = 7.037, 95% CI = 3.370– 14.695), APOE (O

Yingbo Ma,1,&ast; Xueqing Ding,1,&ast; Mingxi Shao,1 Yichao Qiu,1 Shengjie Li,1 Wenjun Cao,1,2 Gezhi Xu2– 4 1Department of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, People’s Republic of China; 2Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, People’s Republic of China; 4NHC Key Laboratory of Myopia, Fudan University, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Shengjie Li; Wenjun CaoDepartment of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Fenyang Road 83th, Xuhui District, Shanghai, People’s Republic of ChinaTel +86-21-64377134Email lishengjie6363020@163.com; 18917785088@163.comPurpose: To investigate the association between serum complement components and age-related macular degeneration (AMD).Patients and Methods: A total of 118 AMD patients and age- and sex-matched 106 control subjects were included. Demographic data and the level of serum complement component (C)1q, C3 and C4 were evaluated. Based on sex, the subjects were stratified into male and female subgroups.Results: The level of C1q (226.31± 45.33mg/dL) was significantly higher and C3 (121.14± 15.76mg/dL) was significantly lower than that in control group (200.03± 38.54mg/dL) (128.42± 19.81mg/dL) in the female AMD patients (p = 0.005, p = 0.045). Logistic regression showed that increased C1q (OR = 1.132, p = 0.016) and decreased C3 (OR = 0.960, p = 0.048) were independent risk factors for female AMD patients. No statistical significance was observed in the male.Conclusion: Increased C1q and decreased C3 were associated with increased risk of AMD, suggesting that the complement classical pathway probably be involved in AMD, especially in female.Keywords: macular degeneration, complement classical pathway, complement compo