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3. Induction chemotherapy with lobaplatin and fluorouracil versus cisplatin and fluorouracil followed by chemoradiotherapy in patients with stage III–IVB nasopharyngeal carcinoma: an open-label, non-inferiority, randomised, controlled, phase 3 trial

Author

Lv, Xing, Cao, Xun, Xia, Wei-Xiong, Liu, Kui-Yuan, Qiang, Meng-Yun, Guo, Ling, Qian, Chao-Nan, Cao, Ka-Jia, Mo, Hao-Yuan, Li, Xian-Ming, Li, Zi-Huang, Han, Fei, He, Yu-Xiang, Liu, Yu-Meng, Wu, Shao-Xiong, Bai, Yong-Rui, Ke, Liang-Ru, Qiu, Wen-Ze, Liang, Hu, Liu, Guo-Ying, Miao, Jing-Jing, Li, Wang-Zhong, Lv, Shu-Hui, Chen, Xi, Zhao, Chong, Xiang, Yan-Qun, and Guo, Xiang

Published
2021
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11. FigureS2 from A Randomized Controlled Trial Comparing Two Different Schedules for Cisplatin Treatment in Patients with Locoregionally Advanced Nasopharyngeal Cancer

Author

Xia, Wei-Xiong, primary, Lv, Xing, primary, Liang, Hu, primary, Liu, Guo-Ying, primary, Sun, Rui, primary, Zeng, Qi, primary, Li, Si-Wei, primary, Mo, Hao-Yuan, primary, Han, Fei, primary, Luo, Dong-Hua, primary, Liu, Qing, primary, Shi, Meng-Yun, primary, Ye, Yan-Fang, primary, Yang, Jing, primary, Ke, Liang-Ru, primary, Qiang, Meng-Yun, primary, Qiu, Wen-Ze, primary, Yu, Ya-Hui, primary, Liu, Kui-Yuan, primary, Huang, Xin-Jun, primary, Li, Wang-Zhong, primary, Lv, Shu-Hui, primary, Cai, Zhuo-Chen, primary, Miao, Jing-Jing, primary, Guo, Ling, primary, Chen, Ming-Yuan, primary, Cao, Ka-Jia, primary, Wang, Lin, primary, Zhao, Chong, primary, Huang, Pei-Yu, primary, Chen, Qiu-Yan, primary, Hua, Yi-Jun, primary, Tang, Lin-Quan, primary, Qian, Chao-Nan, primary, Mai, Hai-Qiang, primary, Guo, Xiang, primary, and Xiang, Yan-Qun, primary

Published
2023
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12. Supplementary Data from A Randomized Controlled Trial Comparing Two Different Schedules for Cisplatin Treatment in Patients with Locoregionally Advanced Nasopharyngeal Cancer

Author

Xia, Wei-Xiong, primary, Lv, Xing, primary, Liang, Hu, primary, Liu, Guo-Ying, primary, Sun, Rui, primary, Zeng, Qi, primary, Li, Si-Wei, primary, Mo, Hao-Yuan, primary, Han, Fei, primary, Luo, Dong-Hua, primary, Liu, Qing, primary, Shi, Meng-Yun, primary, Ye, Yan-Fang, primary, Yang, Jing, primary, Ke, Liang-Ru, primary, Qiang, Meng-Yun, primary, Qiu, Wen-Ze, primary, Yu, Ya-Hui, primary, Liu, Kui-Yuan, primary, Huang, Xin-Jun, primary, Li, Wang-Zhong, primary, Lv, Shu-Hui, primary, Cai, Zhuo-Chen, primary, Miao, Jing-Jing, primary, Guo, Ling, primary, Chen, Ming-Yuan, primary, Cao, Ka-Jia, primary, Wang, Lin, primary, Zhao, Chong, primary, Huang, Pei-Yu, primary, Chen, Qiu-Yan, primary, Hua, Yi-Jun, primary, Tang, Lin-Quan, primary, Qian, Chao-Nan, primary, Mai, Hai-Qiang, primary, Guo, Xiang, primary, and Xiang, Yan-Qun, primary

Published
2023
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18. A Randomized Controlled Trial Comparing Two Different Schedules for Cisplatin Treatment in Patients with Locoregionally Advanced Nasopharyngeal Cancer

Author

Xia, Wei-Xiong, primary, Lv, Xing, additional, Liang, Hu, additional, Liu, Guo-Ying, additional, Sun, Rui, additional, Zeng, Qi, additional, Li, Si-Wei, additional, Mo, Hao-Yuan, additional, Han, Fei, additional, Luo, Dong-Hua, additional, Liu, Qing, additional, Shi, Meng-Yun, additional, Ye, Yan-Fang, additional, Yang, Jing, additional, Ke, Liang-Ru, additional, Qiang, Meng-Yun, additional, Qiu, Wen-Ze, additional, Yu, Ya-Hui, additional, Liu, Kui-Yuan, additional, Huang, Xin-Jun, additional, Li, Wang-Zhong, additional, Lv, Shu-Hui, additional, Cai, Zhuo-Chen, additional, Miao, Jing-Jing, additional, Guo, Ling, additional, Chen, Ming-Yuan, additional, Cao, Ka-Jia, additional, Wang, Lin, additional, Zhao, Chong, additional, Huang, Pei-Yu, additional, Chen, Qiu-Yan, additional, Hua, Yi-Jun, additional, Tang, Lin-Quan, additional, Qian, Chao-Nan, additional, Mai, Hai-Qiang, additional, Guo, Xiang, additional, and Xiang, Yan-Qun, additional

Published
2021
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21. Engineered Coatings via the Assembly of Amino‐Quinone Networks

Author

Zhong, Qi‐Zhi, primary, Richardson, Joseph J., additional, He, Ai, additional, Zheng, Tian, additional, Lafleur, René P. M., additional, Li, Jianhua, additional, Qiu, Wen‐Ze, additional, Furtado, Denzil, additional, Pan, Shuaijun, additional, Xu, Zhi‐Kang, additional, Wan, Ling‐Shu, additional, and Caruso, Frank, additional

Published
2020
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22. Docetaxel and cisplatin induction chemotherapy with or without fluorouracil in locoregionally advanced nasopharyngeal carcinoma: A retrospective propensity score matching analysis.

Author

Tao, Hao‐Yun, Zhan, Ze‐Jiang, Qiu, Wen‐Ze, Liao, Kai, Yuan, Ya‐Wei, and Zheng, Rong‐Hui

Subjects
INDUCTION chemotherapy, PROPENSITY score matching, NASOPHARYNX cancer, DOCETAXEL, CISPLATIN, NASOPHARYNX tumors
Abstract

Purpose: To investigate whether the addition of fluorouracil to docetaxel and cisplatin induction chemotherapy (IC) can truly improve the prognosis of patients with locoregionally advanced nasopharyngeal carcinoma (NPC). Methods: A total of 801 patients newly diagnosed with non‐metastatic locoregionally advanced NPC were included as the subjects. In this study, propensity score matching (PSM) was used for analysis of overall survival (OS), distant metastasis‐free survival (DMFS), progression‐free survival (PFS) and locoregional relapse‐free survival (LRRFS), and the chi‐squared test or Fisher's exact test was used to investigate toxic reactions. Results: Patients received treatment with docetaxel and cisplatin (TP) or docetaxel, cisplatin and fluorouracil (TPF). With a median follow‐up time of 60 months (range: 5–124 months), the TPF group had better 5‐year OS (84.7% vs 79.0%; P = 0.037), PFS (84.6% vs 76.8%; P = 0.008) and DMFS (89.5% vs 82.3%; P = 0.004) than the TP group. After PSM, 258 patients were matched in each cohort. The Kaplan–Meier analysis showed that the 5‐year OS, PFS and DMFS were 85.5%, 84.2% and 89.2%, respectively, in the TPF group, higher than the 80.8%, 75.0% and 81.4%, respectively, in the TP group (P = 0.048, 0.009 and 0.006, respectively). Moreover, the multivariate analysis revealed that different IC regimens were independent prognostic factors for PFS and DMFS (P = 0.014 and 0.010, respectively). Conclusion: This study found that compared with the TP regimen, TPF induction chemotherapy is associated with improved survival in patients with locoregionally advanced NPC. TPF can produce more mucosal and nausea/vomiting adverse reactions than TP. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Engineered Coatings via the Assembly of Amino‐Quinone Networks.

Author

Zhong, Qi‐Zhi, Richardson, Joseph J., He, Ai, Zheng, Tian, Lafleur, René P. M., Li, Jianhua, Qiu, Wen‐Ze, Furtado, Denzil, Pan, Shuaijun, Xu, Zhi‐Kang, Wan, Ling‐Shu, and Caruso, Frank

Subjects
CONTACT angle, BRANCHED polymers, SURFACE coatings, ZETA potential, SMALL molecules, POLYAMINES, QUINONE, ORNITHINE decarboxylase
Abstract

Engineering coatings with precise physicochemical properties allows for control over the interface of a material and its interactions with the surrounding environment. However, assembling coatings with well‐defined properties on different material classes remains a challenge. Herein, we report a co‐assembly strategy to precisely control the structure and properties (e.g., thickness, adhesion, wettability, and zeta potential) of coatings on various materials (27 substrates examined) using quinone and polyamine building blocks. By increasing the length of the amine building blocks from small molecule diamines to branched amine polymers, we tune the properties of the films, including the thickness (from ca. 5 to ca. 50 nm), interfacial adhesion (0.05 to 5.54 nN), water contact angle (130 to 40°), and zeta potential (−42 to 28 mV). The films can be post‐functionalized through the in situ formation of diverse nanostructures, including nanoparticles, nanorods, and nanocrystals. Our approach provides a platform for the rational design of engineered, substrate‐independent coatings for various applications. [ABSTRACT FROM AUTHOR]

Published
2021
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26. Comparison between lobaplatin and cisplatin plus 5-fluorouracil combined with intensity-modulated radiotherapy for locoregionally advanced nasopharyngeal carcinoma: A multicenter randomized phase III clinical trial.

Author

Liu, Kuiyuan, primary, Xia, Wei-Xiong, additional, Qiu, Wen-Ze, additional, Yu, Ya-Hui, additional, Liu, Guo-Ying, additional, Liang, Hu, additional, Li, Wang-Zhong, additional, Lv, Shu-Hui, additional, Ke, Liang-Ru, additional, Mo, Hao-Yuan, additional, Ling, Guo, additional, Chen, Ming-Yuan, additional, Cao, Ka-Jia, additional, Zhao, Chong, additional, Qian, Chao-Nan, additional, Lv, Xing, additional, Yanqun, Xiang, additional, Guo, Xiang, additional, and Huang, Xin-Jun, additional

Published
2018
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29. The plasma Epstein–Barr virus DNA level guides precision treatment for nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: a large population-based cohort study from an endemic area

Author

Liang, Hu, primary, Lv, Xing, additional, Wang, Lin, additional, Wu, Yi-Shan, additional, Sun, Rui, additional, Ye, Yan-Fang, additional, Ke, Liang-Ru, additional, Yang, Qin, additional, Yu, Ya-Hui, additional, Qiu, Wen-Ze, additional, Liu, Guo-Ying, additional, Huang, Xin-Jun, additional, Li, Wang-Zhong, additional, Lv, Shu-Hui, additional, Guo, Xiang, additional, Xiang, Yan-Qun, additional, and Xia, Wei-Xiong, additional

Published
2018
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30. Concurrent Chemoradiotherapy versus Intensity-modulated Radiotherapy Alone for Elderly Nasopharyngeal Carcinoma Patients with Pre-treatment Epstein-Barr Virus DNA: A Cohort Study in an Endemic Area with Long-term Follow-up

Author

Yang, Qin, primary, Zhao, Ting-Ting, additional, Qiang, Meng-Yun, additional, Hu, Liang, additional, Lv, Xing, additional, Ye, Yan-Fang, additional, Ke, Liang-Ru, additional, Yu, Ya-Hui, additional, Qiu, Wen-Ze, additional, Liu, Guo-Ying, additional, Huang, Xin-Jun, additional, Li, Wang-Zhong, additional, Lv, Shu-Hui, additional, Sun, Yao, additional, Zhang, Lu-Yao, additional, Pei, Fei, additional, Guo, Xiang, additional, Xiang, Yan-Qun, additional, Qian, Chao-Nan, additional, Huang, Bi-Jun, additional, and Xia, Wei-Xiong, additional

Published
2018
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34. Safety and efficacy of lobaplatin combined with 5-fluorouracil as first-line induction chemotherapy followed by lobaplatin-radiotherapy in locally advanced nasopharyngeal carcinoma: preliminary results of a prospective phase II trial

Author

Ke, Liang-Ru, primary, Xia, Wei-Xiong, additional, Qiu, Wen-Ze, additional, Huang, Xin-Jun, additional, Yang, Jing, additional, Yu, Ya-Hui, additional, Liang, Hu, additional, Liu, Guo-Ying, additional, Ye, Yan-Fang, additional, Xiang, Yan-Qun, additional, Guo, Xiang, additional, and Lv, Xing, additional

Published
2017
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39. Surface Deposition of Juglone/FeIIIon Microporous Membranes for Oil/Water Separation and Dye Adsorption

Author

Yu, Hui, Zhong, Qi-Zhi, Liu, Tian-Geng, Qiu, Wen-Ze, Wu, Bai-Heng, Xu, Zhi-Kang, and Wan, Ling-Shu

Abstract

Deposition of dopamine and tannic acid has received great attention in the fields of surface and interface science and technology. The deposition behaviors of various metal–phenolic systems have been investigated, and it is generally accepted that at least one catechol group is essential to the formation of the coatings. Herein, we report a novel and effective surface-coating system based on the coordination complexes of FeIIIions with a natural product juglone that contains only one phenolic hydroxyl. We investigated the deposition behaviors of this novel system on various substrates. Microporous polypropylene membrane modified with juglone/FeIIIcoatings is superhydrophilic and underwater superoleophobic, showing high separation efficiency and good reusability for various oil/water emulsions. In addition, the modified membrane can adsorb anionic dyes and selectively remove them from dye mixtures with high efficiency. We further demonstrated that the coating is a result of the synergetic effect of juglone/FeIIIcoordination and FeIIIhydrolysis. This work not only provides new insights into surface deposition systems but also expands the polyphenol family for surface coatings of multifunctional materials.

Published
2019
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44. Safety and efficacy of lobaplatin combined with 5-fluorouracil as first-line induction chemotherapy followed by lobaplatin-radiotherapy in locally advanced nasopharyngeal carcinoma: preliminary results of a prospective phase II trial.

Author

Liang-Ru Ke, Wei-Xiong Xia, Wen-Ze Qiu, Xin-Jun Huang, Jing Yang, Ya-Hui Yu, Hu Liang, Guo-Ying Liu, Yan-Fang Ye, Yan-Qun Xiang, Xiang Guo, Xing Lv, Ke, Liang-Ru, Xia, Wei-Xiong, Qiu, Wen-Ze, Huang, Xin-Jun, Yang, Jing, Yu, Ya-Hui, Liang, Hu, and Liu, Guo-Ying

Subjects
ANTINEOPLASTIC agents, FLUOROURACIL, CANCER chemotherapy, RADIOTHERAPY, CARCINOMA, THERAPEUTICS, CANCER treatment, CANCER, CLINICAL trials, COMBINED modality therapy, COMPARATIVE studies, HYDROCARBONS, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, NASOPHARYNX tumors, ORGANOPLATINUM compounds, PROGNOSIS, RESEARCH, SAFETY, SURVIVAL, TUMOR classification, EVALUATION research, TUMOR treatment
Abstract

Background: Due to improvements in imaging and radiological techniques as well as the use of chemotherapy, distant metastasis has become the predominant mode of treatment failure in patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Platinum-based systemic chemotherapy has shown survival benefits and is now the standard strategy for systemic therapy in patients with LA-NPC. Notably, the third-generation platinum reagent lobaplatin has shown anti-tumor effects in several solid tumors with lower incidences of gastrointestinal, hepatic and renal toxicity relative to other platinum drugs. However, the safety and efficacy of lobaplatin as a first-line regimen in patients with LA-NPC are undetermined.Methods: Patients with stage III-IVa-b NPC received lobaplatin at a dose of 30 mg/m2 on days 1 and 22 combined with a continuous 120-h intravenous injection of 5-fluorouracil at a dose of 4 g/m2 followed by lobaplatin at a dose of 50 mg/m2 on days 43 and 64 concomitant with intensity-modulated radiation therapy. Objective response rates and acute toxicity were assessed based on RECIST (1.1) and CTCAE v.3.0, respectively. Kaplan-Meier analysis was used to calculate survival rates.Results: Fifty-nine patients were enrolled, and 44 patients (74.6%) received allocated cycles of chemotherapy. The objective response rates were 88.1% (95% confidence interval [CI], 0.77 to 0.95) and 100% after induction chemotherapy (ICT) and concurrent chemoradiotherapy (CRT), respectively. With a median follow-up period of 44 months, the 3-year estimated progression-free survival and overall survival were 86.4% (95% CI, 69.8 to 98.8) and 94.9% (95% CI, 89.5 to 100), respectively. The most common grade 3-4 toxicities were neutropenia (8.5%) and thrombocytopenia (40.7%) after ICT and CRT, respectively.Conclusion: Lobaplatin combined with 5-fluorouracil followed by lobaplatin-RT treatment showed encouraging anti-tumor effects with tolerable toxicities in patients with LA-NPC. Randomized controlled trials of lobaplatin in patients with LA-NPC are warranted.Trial Registration: This trial was registered with the Chinese Clinical Trials Registry and approved on March 31st, 2012, number ChiCTR-ONC-12002060 . [ABSTRACT FROM AUTHOR]

Published
2017
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47. Surface Deposition of Juglone/Fe III on Microporous Membranes for Oil/Water Separation and Dye Adsorption.

Author

Yu H, Zhong QZ, Liu TG, Qiu WZ, Wu BH, Xu ZK, and Wan LS

Abstract

Deposition of dopamine and tannic acid has received great attention in the fields of surface and interface science and technology. The deposition behaviors of various metal-phenolic systems have been investigated, and it is generally accepted that at least one catechol group is essential to the formation of the coatings. Herein, we report a novel and effective surface-coating system based on the coordination complexes of Fe III ions with a natural product juglone that contains only one phenolic hydroxyl. We investigated the deposition behaviors of this novel system on various substrates. Microporous polypropylene membrane modified with juglone/Fe III coatings is superhydrophilic and underwater superoleophobic, showing high separation efficiency and good reusability for various oil/water emulsions. In addition, the modified membrane can adsorb anionic dyes and selectively remove them from dye mixtures with high efficiency. We further demonstrated that the coating is a result of the synergetic effect of juglone/Fe III coordination and Fe III hydrolysis. This work not only provides new insights into surface deposition systems but also expands the polyphenol family for surface coatings of multifunctional materials.

Published
2019
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