84 results on '"Qing-qing Zhu"'
Search Results
2. Non-linear dose-response relation between urinary levels of nicotine and its metabolites and cognitive impairment among an elderly population in China
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Tian Li, Wei Liu, Ya-jun Yue, Shao-you Lu, Lu-lin Nie, Xi-fei Yang, Qing-qing Zhu, Bo Zhu, Lu Wang, Fei-qi Zhu, Li Zhou, Jia-fei Zhang, Er-wei Gao, Kai-wu He, Li Liu, Fang Ye, Jian-jun Liu, Jing Yuan, and Lin Wang
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Nicotine exposure ,Tobacco smoke exposure ,Mini-Cog test ,Conditional logistic regression ,Dose-response relationship ,Environmental pollution ,TD172-193.5 ,Environmental sciences ,GE1-350 - Abstract
Background: Active smoking and exposure to environmental tobacco smoke may be related to cognitive function decline. We assessed the associations of urinary levels of nicotine and its metabolites with cognitive function. Methods: A total of 553 elder adults at high risk of cognitive impairment and 2212 gender- and age-matched individuals at low risk of cognitive impairment were selected at a ratio of 1: 4 from the remained individuals (n = 6771) who completed the baseline survey of the Shenzhen Ageing-Related Disorder Cohort, after excluding those with either Alzheimer’s disease, Parkinson’s syndrome or stroke as well as those with missing data on variables (including active and passive smoking status, Mini-Cog score). Urinary levels of nicotine and its metabolites and cognitive function for all individuals were measured by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) and assessed using the Mini-Cog test, respectively. Associations of urinary levels of nicotine and its metabolites with cognitive function were analyzed by conditional logistic regression models. Results: Individuals in the highest tertile of urinary OHCotGluc (OR: 1.52, 95%CI: 1.19–1.93) or NNO (OR: 1.50, 95%CI: 1.16–1.93) levels as well as in the second tertile of urinary ∑Nic level (OR: 1.43, 95%CI: 1.13–1.82) were at higher risk of cognitive impairment compared with those in the corresponding lowest tertile. Restricted cubic spline models revealed the non-linear dose-response relationships between urinary levels of OHCotGluc, NNO or ∑Nic and the risk of cognitive impairment. Conclusions: Urinary levels of OHCotGluc, NNO or ∑Nic exhibited a non-linear dose-response relationship with cognitive function in the urban elderly.
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- 2021
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3. Epidemiological characteristics of pulmonary tuberculosis in Anhui Province, Eastern China from 2013 to 2018.
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Qing-Qing Zhu, Qian Wu, Ai-Min Wang, Fang-Jin Bao, Yong-Zhong Zhang, Jie Liu, Jun-Wei Yan, Xue-Hui Fang, Ling Li, Ze-Kun Zhang, Rong Wang, Xun-Di Bao, Song Yao, and Hai-Feng Pan
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Medicine ,Science - Abstract
ObjectivePulmonary tuberculosis (TB) is a severe infectious respiratory disease, the burden of which remains high in China. To provide scientific evidence for developing more targeted prevention and control strategies, this study aimed to determine the incidence trends and explore the epidemiological characteristics of pulmonary TB in Anhui Province, Eastern China between 2013 and 2018.MethodsThe retrospective study analyzed information regarding pulmonary TB cases reported by the National Infectious Disease Reporting System and census data collected from the Anhui Provincial Bureau of Statistics.ResultsOverall, 211,892 cases of TB patients were reported in Anhui Province, China between 2013 and 2018, with an average annual reported incidence rate of 57.7 per 100,000 persons. A significant decrease in the incidence rate of pulmonary TB (p < 0.001) was observed during the study period. Men had a higher incidence rate of pulmonary TB than women (p < 0.001). The highest annual average reported incidence rate was 204.2 per 100,000 persons in those aged 70-74 years. The number of farmers with pulmonary TB, i.e., 155,415, accounted for 73.4% of all cases. Moreover, the peak period of reported cases was from January to March. Four cities along the Yangtze River-Anqing, Tongling, Chizhou, and Wuhu-reported significantly higher incidence rates of pulmonary TB than other cities (p < 0.001).ConclusionsFrom 2013 to 2018, there was a significant decline in the incidence rate of pulmonary TB in Anhui Province, with peaks occurring from January to March. Prevention and control strategies targeting men, people aged 70-74 years, farmers, and the four cities along the Yangtze River should be strengthened.
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- 2020
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4. PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway
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Ping Zhan, Bin Zhang, Guang-min Xi, Ying Wu, Hong-bing Liu, Ya-fang Liu, Wu-jian Xu, Qing-qing Zhu, Feng Cai, Ze-jun Zhou, Ying-ying Miu, Xiao-xia Wang, Jia-jia Jin, Qian Li, Li-ping Qian, Tang-feng Lv, and Yong Song
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PRC1 ,Lung adenocarcinoma ,Prognosis ,Proliferation ,Wnt/β-catenin signaling ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Protein regulator of cytokinesis-1 (PRC1) belongs to the microtubule-associated proteins (MAPs) family, and is involved in cytokinesis. Recent investigations suggest PRC1 involvement in human carcinogenesis, including breast carcinoma, hepatocellular carcinoma and etc. However, whether PRC1 contributes to lung adenocarcinoma tumorigenesis remains unknown. Methods Quantitative reverse-transcription polymerase chain reaction (qRT-PCR), Western blotting and Immunohistochemical staining (IHC) were used to evaluate and contrast the PRC1 expression profile in lung adenocarcinoma and adjacent normal lung tissues. We examined the clinical use of PRC1 in lung adenocarcinoma prognosis. Additionally, the tumorigenesis impact of PRC1 in lung adenocarcinoma cells was verified via in vitro and in vivo metastasis and tumorigenesis assays. Notably, Next Generation Sequencing (NGS) was performed to investigate the molecular mechanism underlying the oncogenic role of PRC1 in lung adenocarcinoma. Results PRC1 mRNA and protein expressions were upregulated in lung adenocarcinoma tissues compared to adjacent normal lung tissues. PRC1 protein overexpression correlated with lymph node metastasis and was an independent poor prognostic factor for lung adenocarcinoma patients. Our data implied that PRC1 depletion limited the proliferation and invasion of lung adenocarcinoma cells in vitro and lowered tumor development and lung metastasis in vivo. Remarkably, limiting PRC1 substantially prompted G2/M phase cell cycle arrest and apoptosis. Mechanistically, by conducting NGS on PRC1-depleted A549 cells and control cells, we discovered that PRC1 expression was significantly correlated with the Wnt signaling pathway. Conclusions This investigation offers confirmation that PRC1 is a prognostic and promising therapeutic biomarker for people with lung adenocarcinoma and takes on a key part in the activation of the Wnt/β-catenin pathway in lung adenocarcinoma development.
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- 2017
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5. Percutaneous intervention versus coronary artery bypass graft surgery in left main coronary artery stenosis: a systematic review and meta-analysis
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Xin-Lin Zhang, Qing-Qing Zhu, Jing-Jing Yang, Yu-Han Chen, Yang Li, Su-Hui Zhu, Jun Xie, Lian Wang, Li-Na Kang, and Biao Xu
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Left main coronary artery disease ,Percutaneous coronary intervention ,Coronary artery bypass graft surgery ,Meta-analysis ,Randomized controlled trials ,Matched observational studies ,Medicine - Abstract
Abstract Background The optimal revascularization technique in patients with left main coronary artery disease (CAD) remains controversial. We aimed to compare the long-term performance of percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) surgery in treatment of left main CAD. Methods PubMed, EMBASE, and the Cochrane Library were searched until November 16, 2016. Results Six randomized controlled trials and 22 matched observational studies including 22,487 patients and 90,167 patient-years of follow-up were included. PCI was associated with an overall higher risk for the major adverse cardiac and cerebrovascular events (hazard ratio (HR), 1.42; 95% confidence interval (CI), 1.14–1.77), mainly driven by higher rates of myocardial infarction (HR, 1.69; 95% CI, 1.22–2.34) and revascularization (HR, 2.80; 95% CI, 1.86–4.22). The overall risks for all-cause death (HR, 1.05; 95% CI, 0.93–1.20), cardiac death (HR, 1.05; 95% CI, 0.69–1.59), stroke (HR, 0.64; 95% CI, 0.33–1.24), and the composite safety endpoint of death, myocardial infarction, or stroke (HR, 1.06; 95% CI, 0.97–1.16) were similar between PCI and CABG. Stratified analysis based on stent types showed that the increased risk for myocardial infarction associated with PCI was only evident in patients with bare-metal stents or early-generation drug-eluting stents (DES), but not newer-generation DES. Stratified analyses based on study designs showed largely similar findings with the overall analyses, except for a significantly higher incidence of myocardial infarction in adjusted studies (HR, 2.01; 95% CI, 1.64–2.45) but a trend toward higher incidence in randomized trials (HR, 1.39; 95% CI, 0.85–2.27) associated with PCI. Conclusions Compared with CABG, PCI with newer-generation DES might be a safe alternative revascularization strategy for treatment of left main CAD, but is associated with more repeat revascularization.
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- 2017
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6. Cardiovascular Safety, Long‐Term Noncardiovascular Safety, and Efficacy of Sodium–Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Systemic Review and Meta‐Analysis With Trial Sequential Analysis
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Xin‐Lin Zhang, Qing‐Qing Zhu, Yu‐Han Chen, Xue‐Ling Li, Fu Chen, Jian‐An Huang, and Biao Xu
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cardiovascular disease ,meta‐analysis ,observational study ,randomized controlled trial ,SGLT2 (sodium–glucose cotransporter 2) inhibitor ,trial sequential analysis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundThe cardiovascular and long‐term noncardiovascular safety and efficacy of SGLT2 (sodium–glucose cotransporter 2) inhibitors have not been well documented. Methods and ResultsFor cardiovascular outcomes, we performed a meta‐analysis with trial sequential analysis of randomized controlled trials and adjusted observational studies, each with a minimum of 26 weeks and 2000 patient‐years of follow‐up. For long‐term noncardiovascular safety and efficacy outcome analyses, we included only randomized controlled trials with at least 2 years and 1000 patient‐years of follow‐up. Five studies with 351 476 patients were included in cardiovascular outcomes analysis. Meta‐analyses showed that SGLT2 inhibitors significantly reduced the risks of major adverse cardiac events (hazard ratio [HR]: 0.80; 95% confidence interval [CI], 0.69–0.92; P=0.002), all‐cause mortality (HR: 0.67; 95% CI, 0.54–0.84; P
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- 2018
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7. Plant Growth Promotion by Spermidine-Producing Bacillus subtilis OKB105
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Shan-Shan Xie, Hui-Jun Wu, Hao-Yu Zang, Li-Ming Wu, Qing-Qing Zhu, and Xue-Wen Gao
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Microbiology ,QR1-502 ,Botany ,QK1-989 - Abstract
The interaction between plants and plant-growth-promoting rhizobacteria (PGPR) is a complex, reciprocal process. On the one hand, plant compounds such as carbohydrates and amino acids serve as energy sources for PGPR. On the other hand, PGPR promote plant growth by synthesizing plant hormones and increasing mineral availability in the soil. Here, we evaluated the growth-promoting activity of Bacillus subtilis OKB105 and identified genes associated with this activity. The genes yecA (encoding a putative amino acid/polyamine permease) and speB (encoding agmatinase) are involved in the secretion or synthesis of polyamine in B. subtilis OKB105. Disruption of either gene abolished the growth-promoting activity of the bacterium, which was restored when polyamine synthesis was complemented. Moreover, high-performance liquid chromatography analysis of culture filtrates of OKB105 and its derivatives demonstrated that spermidine, a common polyamine, is the pivotal plant-growth-promoting compound. In addition, real-time polymerase chain reaction analysis revealed that treatment with B. subtilis OKB105 induced expansin gene (Nt-EXPA1 and Nt-EXPA2) expression and inhibited the expression of the ethylene biosynthesis gene ACO1. Furthermore, enzyme-linked immunosorbent assay analysis showed that the ethylene content in plant root cells decreased in response to spermidine produced by OKB105. Therefore, during plant interactions, OKB105 may produce and secrete spermidine, which induces expansin production and lowers ethylene levels.
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- 2014
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8. Observation and Analysis of Micro- and Meso-structure of Soil in the Shear Zone of Guoyemoli Landslide in Zhouqu County
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Bing-xu, Chen, primary, Qiang-qiang, Miao, additional, Qing-qing, Zhu, additional, Wan-zhi, Cao, additional, Ji-zhong, Gan, additional, and Hao-xiang, Guo, additional
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- 2024
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9. Diversity of staminal nectariferous appendages in disymmetric and zygomorphic flowers of Fumarioideae (Papaveraceae)
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Xiao-Jia Wang, Xu-Qian Lv, Qing-Qing Zhu, and Xiao-Hui Zhang
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Cell Biology ,Plant Science ,General Medicine - Published
- 2023
10. Low concentrations of benzophenone-type UV-filters impair testis development in the amphibian Xenopus laevis
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Hong-Mei Li, Ying-Chi Zhang, Yuan-Yuan Li, Qing-Qing Zhu, Jie Li, Hai-Ming Xu, Yi-Ming Xiong, and Zhan-Fen Qin
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Health, Toxicology and Mutagenesis ,Aquatic Science - Abstract
Benzophenone-type UV filters (BPs) are ubiquitous contaminants in aquatic environments, possibly posing ecological risks to aquatic populations. So far, little is known about the potential adverse effects of BPs on amphibians. Given their potential estrogenic property, we investigated the detrimental effects of the commonly used BPs, BP-3, BP-2, and BP-1, on testis development in amphibians using Xenopus laevis as a model species. Following exposure to 10, 100, 1000 nM BP-3, BP-2, or BP-1 from stages 45/46 to 52, tadpoles presented morphological abnormal testes, characterized by reduced gonomere size and testis area, coupled with suppressed cell proliferation. Meanwhile, the downregulation of testis-biased gene expression and the upregulation of ovary-biased gene expression were observed in BPs-treated testes. Moreover, the estrogen receptor (ER) antagonist ICI 182780 significantly antagonized ovary-biased gene upregulation caused by BPs, suggesting that the effects of BPs on testis differentiation could be mediated by ER, at least partially. Of note, the effects of BPs were not concentration-dependent, but the lowest concentration generally exerted significant effects. Altogether, these observations indicate that the three BPs inhibited testis differentiation and exerted feminizing effects. Importantly, when BP-2 exposure was extended to two months post-metamorphosis, testes of froglets were generally less-developed, with relatively fewer spermatocytes, more spermatogonia, and poorly formed seminiferous tubules. Considering the fact that the lowest concentration (10 nM) of BPs in this study are detectable in aquatic environments, we conclude that BP-3, BP-2, and BP-1, even at environmentally relevant concentrations, can retard testis differentiation at pre-metamorphic stages and cause testis dysgenesis after metamorphosis in the amphibian X. laevis. Our findings suggest that ubiquitous BPs in aquatic environments could pose a potential risk to amphibians.
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- 2022
11. Stamen and pollen development in Menispermaceae with contrasting androecium structure
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Hui-Yan Zhang, Xiao-Yan Zhang, Kun Ning, Xiao-Ling Yan, Qiao-Juan Wang, Zi-Xuan Huang, Qing-Qing Zhu, Liang Zhao, Yu-Qu Zhang, Yi Ren, and Xiao-Hui Zhang
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Plant Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2022
12. How do fertile stamens and staminodes go differently in Kingdonia uniflora? Evidence from stamen numbers, ontogeny, and structure
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Kun Ning, Qing-Qing Zhu, and Xiao-Hui Zhang
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Ecology ,Plant Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2023
13. Factors Associated with Non-Adherence for Prescribed Treatment in 201 Patients with Multidrug-Resistant and Rifampicin-Resistant Tuberculosis in Anhui Province, China
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Qing-Qing Zhu, Jie Wang, Napoleon Bellua Sam, Jie Luo, Jie Liu, and Hai-Feng Pan
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China ,Cross-Sectional Studies ,Risk Factors ,Tuberculosis, Multidrug-Resistant ,Antitubercular Agents ,Odds Ratio ,Humans ,General Medicine ,Rifampin - Abstract
BACKGROUND This study aimed to investigate the factors associated with non-adherence of prescribed treatment in patients with multidrug-resistant and rifampicin-resistant tuberculosis (MDR/RR-TB) in Anhui Province, China. MATERIAL AND METHODS A cross-sectional survey was conducted in each designated hospital between March 2020 and May 2021. A structured questionnaire was designed to collect categorical characteristics and the historical data of the study participants. Non-adherence was determined from patient medical records and face-to-face interviews using the questionnaire at each designated hospital for MDR/RR-TB. RESULTS A total of 201 patients with confirmed sputum cultures positive for MDR/RR-TB were enrolled, 27.4% of whom were non-adherent to MDR/RR-TB treatment. In Anhui, MDR patients had a high incidence of adverse events, of which gastrointestinal reactions accounted for the majority. Absence of other chronic diseases (odds ratio (OR) 0.401; 95% confidence interval (CI) 0.203-0.791) and having no drug discontinuation (OR 0.040; 95% CI 0.018-0.091) were protective predictors of adherence. Patients with MDR/RR-TB with secondary education level and above and monthly family income of $309.4 USD or higher were more likely to follow the guidelines. Those who received anti-tuberculosis treatment and those who lived in suburban areas were less likely to adhere to the treatment. Binary-logistic regression indicated that the risk factor of non-adherence was drug discontinuation. CONCLUSIONS Low education level, place of residence, poor financial conditions, presence of other chronic diseases, discontinuation of medication, and frequency of anti-tuberculosis treatments were influential factors of adherence to MDR/RR-TB treatment.
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- 2022
14. Epithelioid angiomyolipoma of the pancreas: A case report and review of the literature
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Zhong-Feng Niu, Qing-Qing Zhu, Fei-Dan Yu, Guangbin Wang, and Yan Wu
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Endoscopic ultrasound ,medicine.medical_specialty ,Epithelioid angiomyolipoma ,Metastasis ,Lesion ,03 medical and health sciences ,Tuberous sclerosis ,0302 clinical medicine ,Magnetic resonance imaging ,Ultrasound ,Case report ,medicine ,Pancreas ,Computed tomography ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Histopathology ,Radiology ,medicine.symptom ,Differential diagnosis ,business - Abstract
Background Angiomyolipomas (AMLs), belonging to the family of mesenchymal tumors, are considered benign lesions that occur mostly in the kidney or as a part of tuberous sclerosis. Epithelioid AML (EAML) is a rare type of AML that appears to have malignant potential. Extrarenal AMLs usually occur in the liver according to the retrieved literature reports. There have been only two previous reports of monofocal primary AML of the pancreas; however, no cases of primary monotypic EAML of the pancreas have been reported. Case summary An asymptomatic 59-year-old woman incidentally revealed a tumor during abdominal ultrasound examination. Routine blood tests and physical examination were within normal limits. Abdominal ultrasound revealed a 1.9-cm hypoechogenic mass in the tail of the pancreas, clearly visualized by endoscopic ultrasound. However, contrast-enhanced abdominal computed tomography scans did not demonstrate the lesion. A subsequent gadolinium-enhanced magnetic resonance imaging scan showed that the lesion had some characteristic manifestations. The lesion was initially thought to be a neuroendocrine tumor (asymptomatic PanNET). After surgical resection, histopathology and immunohistochemistry confirmed the diagnosis of EAML. At the 6-mo follow-up, no recurrence, spread, or metastasis was identified on computed tomography or magnetic resonance imaging. Conclusion The preoperative diagnosis of pancreatic AML is extremely difficult. Imaging techniques are essential for providing valuable morphological features for differential diagnosis.
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- 2021
15. [Evaluation of methodological and reporting quality of domestic clinical guidelines for hyperuricemia]
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Dong-Jun, Wang, Ying, Zhang, Zhi-Kui, Tian, Mi, Zhou, Yuan-Yuan, Guan, Qing-Qing, Zhu, Zong-Hui, Zhou, Xuan, Sun, Chun-Ying, Tian, and Hong-Wu, Wang
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China ,Consensus ,Publications ,Humans ,Hyperuricemia ,Reference Standards - Abstract
This study aims to evaluate the methodological and reporting quality of diagnosis and treatment guidelines for hyperuricemia as well as the expert consensuses and promote the understanding and application of the diagnosis and treatment guidelines for hyperuricemia. Withquot;hyperuricemiaquot;quot;guidelinesquot;quot;consensusquot;quot;recommendationsquot; as the key words in titles, the authors searched for the published clinical guidelines on hyperuricemia in Chinese against CNKI, Wanfang, VIP, Medlive and the official website of the industry association. The retrieval time limit was until May 31, 2021. The appraisal of guidelines for research and evaluation Ⅱ(AGREEⅡ) and the reporting items for practice guidelines in health care(RIGHT) were employed to evaluate the methodological quality and reporting quality of 14 guidelines/consensuses included. The average scores of the guidelines/consensuses were 80.85%(48.61%-98.61%) for the domain of scope and purpose, 34.52%(0-69.44%) for the domain of stakeholder involvement, 35.53%(6.25%-92.19%) for the domain of rigor of development, 55.85%(23.61%-86.11%) for the domain of clarity of presentation, 26.19%(0-76.04%) for the domain of applicability, and 21.42%(0-50.00%) for the domain of editorial independence. Nine guidelines/consensuses were of medium overall quality with grade B recommendation, and five guidelines/consensuses were of poor quality with grade C recommendation. The RIGHT classified the fourteen guidelines/consensuses into one of high reporting quality, three of medium reporting quality, and ten of low reporting quality. The results of this study indicate that the standardization and rigor of the methodological quality and the reporting quality of the clinical guidelines/consensuses for hyperuricemia in China remain to be strengthened.
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- 2022
16. Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly
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Jian Hou, Chao Huang, Bo Zhu, Wei Liu, Qing-qing Zhu, Lu Wang, Tian Li, Chun-jie Yuan, Shao-yang Lai, De-sheng Wu, Fei-qi Zhu, Jia-fei Zhang, Jia Huang, Er-wei Gao, Yi-dan Huang, Lu-lin Nie, Shao-you Lu, Xi-fei Yang, Li Zhou, Fang Ye, Jing Yuan, and Jian-jun Liu
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Health, Toxicology and Mutagenesis ,Environmental Chemistry ,General Medicine ,Pollution - Abstract
Active and passive exposure to tobacco smoke may increase risk of cognitive decline. However, effects of enhanced the aging process on the association of urinary nicotine metabolites with cognitive impairment remain unclear. In this study, 6657 Chinese older adults completed the physical examinations and cognitive tests. We measured urinary nicotine metabolite levels, mitochondrial DNA copy number (mtDNA-CN), and relative telomere length (RTL) and analyzed effects of urinary nicotine metabolites and their interaction with mtDNA-CN or RTL on cognitive impairment by generalized linear models and qg-computation, respectively. Each 1-unit increase in urinary 3-OHCot, 3-OHCotGluc, CotGluc, or NicGluc levels corresponded to a 1.05-, 1.09-, 1.04-, and 0.90-fold increased risk of cognitive impairment. Each 1-quantile increment in the mixture level of 8 nicotine metabolites corresponded to an increment of 1.40- and 1.34-fold risk of cognitive impairment in individuals with longer RTL or low mtDNA-CN. Urinary 3-OHCotGluc and RTL or mtDNA-CN exhibited an additive effect on cognitive impairment in addition to the mixture of 8 nicotine metabolites and mtDNA-CN. The findings suggested that aging process may increase the risk of tobacco-related cognitive impairment.
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- 2022
17. The diversity of elaborate petals in Isopyreae (Ranunculaceae): a special focus on nectary structure
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Qing-Qing Zhu, Cheng Xue, Li Sun, Xin Zhong, Xin-Xin Zhu, Yi Ren, and Xiao-Hui Zhang
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Cell Biology ,Plant Science ,General Medicine - Abstract
Elaborate petals are highly diverse in morphology, structure, and epidermal differentiation and play a key role in attracting pollinators. There have been few studies on the elaborate structure of petals in the tribe Isopyreae (Ranunculaceae). Seven genera in Isopyreae (Aquilegia, Semiaquilegia, Urophysa, Isopyrum, Paraquilegia, Dichocarpum, and Leptopyrum) have petals that vary in morphology, and two genera (Enemion and Thalictrum) have no petals. The petals of nine species belonged to 7 genera in the tribe were studied to reveal their nectary structure, epidermal micromorphology and ancestral traits. The petal nectaries of Isopyreae examined in this study were located at the tip of spurs (Aquilegia yabeana and A. rockii), or the bottom of shallow sacs (Semiaquilegia adoxoides, Urophysa henryi, Isopyrum manshuricum, and Paraquilegia microphylla), a cup-shaped structure (Dichocarpum fargesii) and a bilabiate structure (Leptopyrum fumarioides). The petal nectary of eight species in Isopyreae (except A. ecalcarata) was composed of secretory epidermis, nectary parenchyma, and vascular tissues, and some sieve tubes reached the secretory parenchyma cells. Among the eight species with nectaries examined in the present study, A. yabeana had the most developed nectaries, with 10-15 layers of secretory parenchyma cells. The epidermal cells of mature petals of the nine species were divided into 11 types. Among these 11 types, there were two types of secretory cells and two types of trichomes. Aquilegia yabeana and A. rockii had the highest number of cell types (eight types), and I. manshuricum and L. fumarioides had the lowest number of cell types (three types). Aquilegia ecalcarata had no secretory cells, and the papillose conical polygonal secretory cells of D. fargesii were different from those of the other seven species with nectaries. Trichomes were found only in Aquilegia, Semiaquilegia, Urophysa, and Paraquilegia. The ancestral mode of nectar presentation in Isopyreae was petals with hidden nectar (70.58%). The different modes of nectar presentation in petals may reflect adaptations to different pollinators in Isopyreae.
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- 2022
18. Diagnostic Performance Using Automated Breast Ultrasound System for Breast Cancer in Chinese Women Aged 40 Years or Older: A Comparative Study
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Li Zhang, Luo-Qian Zhu, Jan Liu, Ling-Yun Bao, Qing-Qing Zhu, Yan-Na Shan, Xiao-Jing Xu, Le-Si Xie, Yan-Juan Tan, and Jing Zhao
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Adult ,China ,medicine.medical_specialty ,Acoustics and Ultrasonics ,Youden's J statistic ,Biophysics ,Breast Neoplasms ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Mammography ,Radiology, Nuclear Medicine and imaging ,Breast ,Prospective Studies ,Breast ultrasound ,Reference standards ,Aged ,Alternative methods ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Reproducibility of Results ,Middle Aged ,medicine.disease ,030220 oncology & carcinogenesis ,Female ,Ultrasonography, Mammary ,Radiology ,Ultrasonography ,business - Abstract
The purpose of this study was to investigate the diagnostic performance of the automated breast ultrasound system (ABUS) compared with hand-held ultrasonography (HHUS) and mammography (MG) for breast cancer in women aged 40 y or older. A total of 594 breasts in 385 patients were enrolled in the study. HHUS, ABUS and MG exams were performed for these patients. Follow-up and pathologic findings were used as the reference standard. Based on the reference standard, 519 units were benign or normal and 75 were malignant. The sensitivity, specificity, accuracy and Youden index were 97.33%, 89.79%, 90.74% and 0.87 for HHUS; 90.67%, 92.49%, 92.26% and 0.83 for ABUS; 84.00%, 92.87%, 91.75% and 0.77 for MG, respectively. The specificity of ABUS was significantly superior to that of HHUS (p = 0.024). The area under the receiver operating characteristic curve was 0.936 for HHUS, which was the highest, followed by 0.916 for ABUS and 0.884 for MG. However, the difference was not statistically significant (p > 0.05). In conclusion, the diagnostic performance of ABUS for breast cancer was equivalent to HHUS and MG and potentially can be used as an alternative method for breast cancer diagnosis.
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- 2019
19. Spatio-temporal variation of Dissolved Organic Matter (DOM) in the Bohai Sea and the Yellow Sea
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Xuan Ji, Ke Liu, Qing-Qing Zhu, Jing Zhang, and Gui-Peng Yang
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Aquatic Science ,Oceanography ,Ecology, Evolution, Behavior and Systematics - Published
- 2022
20. Aerosol Inhalation-mediated Delivery of an Adeno-associated Virus 5-expressed Antagonistic Interleukin-4 Mutant Ameliorates Experimental Murine Asthma
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Qing-qing Zhu, Guangrui Huang, Li-chun Tian, Jun Li, and Ai-jie Liu
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0301 basic medicine ,Ovalbumin ,medicine.disease_cause ,Virus ,law.invention ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Parvovirinae ,Mutant protein ,law ,Administration, Inhalation ,medicine ,Animals ,Tissue Distribution ,Lung ,Adeno-associated virus ,Interleukin 4 ,Mice, Inbred BALB C ,Inhalation ,medicine.diagnostic_test ,Chemistry ,Interleukin-4 Receptor alpha Subunit ,Interleukin ,Genetic Therapy ,General Medicine ,Dependovirus ,respiratory system ,Molecular biology ,Asthma ,Disease Models, Animal ,030104 developmental biology ,Bronchoalveolar lavage ,030220 oncology & carcinogenesis ,Recombinant DNA ,Cytokines ,Female ,Interleukin-4 ,Bronchoalveolar Lavage Fluid - Abstract
Background T helper 2 (Th2) lymphocytes and associated interleukin (IL) 4 and IL-13 play crucial roles in asthma pathogenesis. In this study, we explored an adeno-associated virus 5 (AAV5) based gene therapy by delivering truncated IL-4 protein to antagonize IL-4 receptor α chain and interrupt asthmatic signal pathway. Results A recombinant adeno-associated virus 5 (AAV5) vector harboring a truncated mouse IL-4 gene (AAV5-mIL-4ΔC22) was prepared. Western blotting showed that the IL-4 mutant protein lacking the C-terminal 22 amino acids was expressed well in AAV5-mIL-4ΔC22 infected 16HBE and BEAS-2B cells. AAV5-drivn green fluorescent protein (AAV5-GFP) served as a control. The biodistribution of vector DNA after AAV5 vector aerosol inhalation was examined by PCR and the result showed that foreign DNA was detectable in the lungs but not in other organs including gonads. The aerosol inhalation-mediated delivery of AAV5-expressed antagonistic IL-4 mutant protein improved the lung function of ovalbumin-induced asthma mice. Conclusions The inhalation of aerosolized AAV5-mIL-4ΔC22 significantly improved the lung function and modulated the immune cell infiltration and associated cytokine expression in the bronchoalveolar lavage fluid (BALF) of ovalbumin-induced asthma mice.
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- 2019
21. Diagnostic Performance of Automated Breast Ultrasound in Differentiating Benign and Malignant Breast Masses in Asymptomatic Women: A Comparison Study With Handheld Ultrasound
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Yingzhao Shen, Yan-Na Shan, Yan-Juan Tan, Chenxiang Jiang, Ling-Yun Bao, Lin Niu, Xiao-Jing Xu, Jian Liu, Luo-Qian Zhu, and Qing-Qing Zhu
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Adult ,China ,medicine.medical_specialty ,Breast imaging ,Breast Neoplasms ,Sensitivity and Specificity ,Asymptomatic ,030218 nuclear medicine & medical imaging ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Breast ,Breast ultrasound ,030219 obstetrics & reproductive medicine ,Handheld ultrasound ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Reproducibility of Results ,Middle Aged ,medicine.disease ,Predictive value ,Comparison study ,Female ,Ultrasonography, Mammary ,Radiology ,medicine.symptom ,business - Abstract
Our aim was to investigate the diagnostic potential of an automated breast ultrasound (ABUS) system in differentiating benign and malignant breast masses compared with handheld ultrasound (HHUS).Women were randomly and proportionally selected from outpatients and underwent both HHUS and ABUS examinations. Masses with final American College of Radiology Breast Imaging Reporting and Data System categories 2 and 3 were considered benign. Masses with final Breast Imaging Reporting and Data System categories 4 and 5 were considered malignant. The diagnosis was confirmed by pathologic results or at least a 1-year follow-up. Automated breast US and HHUS were compared on the basis of their sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. Diagnostic consistency and areas under the receiver operating characteristic curves were analyzed. The maximum diameters of masses were compared among HHUS, ABUS, and pathologic results.A total of 599 masses in 398 women were confirmed by pathologic results or at least a 1-year follow-up; 103 of 599 masses were malignant, and 496 were benign. There were no significant differences between ABUS and HHUS in terms of diagnostic accuracy (80.1% versus 80.6%), specificity (77.62% versus 80.24%), positive predictive value (46.12% versus 46.46%), and negative predictive value (97.96% versus 95.67%). There were significant differences in sensitivity (92.23% versus 82.52%; P .01) and areas under the curve (0.85 versus 0.81; P .05) between ABUS and HHUS. The correlation of the maximum diameter was slightly higher between ABUS and pathologic results (r = 0.885) than between HHUS and pathologic results (r = 0.855), but the difference was not significant (P .05).Automated breast US is better than HHUS in differentiating benign and malignant breast masses, especially with respect to specificity.
- Published
- 2019
22. Identification of plasma SAA2 as a candidate biomarker for the detection and surveillance of non-small cell lung cancer
- Author
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Run-Hao Xu, Minjie Meng, Hui-Min Wei, Zhi-Lei Cui, Qing-Qing Zhu, Qi-Qi Wu, Fafu Zhang, Shulin Zhang, and Bin Han
- Subjects
Oncology ,Male ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Internal medicine ,Carcinoma, Non-Small-Cell Lung ,medicine ,Biomarkers, Tumor ,Humans ,Stage (cooking) ,Lung cancer ,Serum Amyloid A Protein ,Lung ,Receiver operating characteristic ,business.industry ,Area under the curve ,medicine.disease ,respiratory tract diseases ,Squamous carcinoma ,medicine.anatomical_structure ,ROC Curve ,Area Under Curve ,Adenocarcinoma ,Biomarker (medicine) ,Female ,business - Abstract
This study aimed to measure the expression of SAA2 in plasma and to assess its diagnostic efficacy as a biomarker for non-small cell lung cancer (NSCLC). The gene expression of SAA2 in NSCLC was analyzed based on a database. Then, SAA2 expression was detected by immunohistochemistry in lung tissue and by enzyme-linked immunosorbent assay in 90 patients with NSCLC and 61 normal controls. Finally, the diagnostic performance was assessed in terms of accuracy, sensitivity, and specificity. At the gene and protein levels, the SAA2 expression was significantly higher in the NSCLC group than in the control group (p < 0.01). It was higher in lung squamous carcinoma than in lung adenocarcinoma and in males than in females, and this trend was also observed in the lung squamous carcinoma group. Of note, the expression of SAA2 increased with increasing disease stage. Receiver operating characteristic (ROC) curve analysis revealed that the sensitivity of SAA2 was 83.61%, the specificity was 91.11%, and the area under the curve (AUC) was 0.9252. Its accuracy was 68.89%, which was higher than that of other conventional diagnostic biomarkers, and the combined application can effectively improve the diagnostic efficiency. Based on the results, SAA2 expression was positively correlated with the disease stage of NSCLC. Notably, SAA2 is more concerning in male patients with lung squamous carcinoma, and it can help in the screening and diagnosis of NSCLC. SAA2 may represent a novel diagnostic biomarker in NSCLC.
- Published
- 2021
23. Effect of Evidence-based Nursing on Perioperative Nursing of Patients with Gastric Cancer
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Ying. Liu, Min. Zhao, Xiao Dong. Yang, Xiao Hui. Cheng, Qing Qing. Zhu, Hui Fang. Zhang, and Zhen Qi.Wei
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Evidence-based nursing ,Perioperative nursing ,business.industry ,Therapeutic effect ,Cancer ,Perioperative ,medicine.disease ,Nursing care ,Ureter ,medicine.anatomical_structure ,Anesthesia ,medicine ,Radical surgery ,business - Abstract
To explore the therapeutic effect of evidence-based nursing on the perioperative care of gastric cancer patients. 81 patients with gastric cancer hospitalized in our department from September 2018 to September 2019 were randomly divided into 40 experimental group and 40 control group; the control group used conventional nursing intervention and the experimental group used evidence-based nursing intervention to compare the surgical index, mental and emotional, clinical index, visual analogue scoring system score and complications of the two groups. The results showed that there were no statistically significant differences in intraoperative bleeding and operation time between the two groups, and the amount of intraoperative fluid replenishment was significantly lower in the experimental group than in the control group; after the nursing intervention, the Self-rating Anxiety Scale and Self-rating Depression Scale scores of the experimental group were lower than those of the control group at 1 d preoperatively and 3 d postoperatively (p
- Published
- 2021
24. Pulmonary artery trunk enlargement on admission as a predictor of mortality in in-hospital patients with COVID-19
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Qing-Qing Zhu, Zhong-Feng Niu, Guoquan Huang, Guangbin Wang, Chao Chen, Fang-Yi Xu, Ting Yue, and Tao Gong
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Adult ,Male ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Pulmonary Artery ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine.artery ,Medicine ,Cutoff ,Humans ,Radiology, Nuclear Medicine and imaging ,Hospital patients ,Hospital Mortality ,Letter to the Editor ,Survival analysis ,Retrospective Studies ,Receiver operating characteristic ,business.industry ,SARS-CoV-2 ,COVID-19 ,Retrospective cohort study ,Middle Aged ,Prognosis ,Trunk ,Hospitalization ,ROC Curve ,030220 oncology & carcinogenesis ,Pulmonary artery ,Cardiology ,Female ,business ,Tomography, X-Ray Computed ,Dilatation, Pathologic - Abstract
To describe the prognostic value of pulmonary artery (PA) trunk enlargement on the admission of in-hospital patients with severe COVID-19 infection by unenhanced CT image.In-hospital patients confirmed COVID-19 from January 18, 2020, to March 7, 2020, were retrospectively enrolled. PA trunk diameters on admission and death events were collected to calculate the optimum cutoff using a receiver operating characteristic curve. According to the cutoff, the subjects on admission were divided into two groups. Then the in-hospital various parameters were compared between the two groups to assess the predictive value of PA trunk diameter.In the 180 enrolled in-hospital patients (46.99 ± 14.95 years; 93 (51.7%) female, 14 patients (7.8%) died during their hospitalization. The optimum cutoff PA trunk diameter to predict in-hospital mortality was 29 mm with a sensitivity of 92.59% and a specificity of 91.11%. Kaplan-Meier survival curves for PA trunk diameter on admission showed that a PA trunk diameter 29 mm was a significant predictor of subsequent death (log-rank 0.001, median survival time of PA 29 mm was 28 days).PA trunk enlargement can be a useful predictive factor for distinguishing between mild and severe COVID-19 disease progression.
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- 2020
25. Petal ontogeny, structure, and pollination system of four Aquilegia species in Midwest China
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Meng Han, Qing-Qing Zhu, Li Sun, Chen-Yu Niu, Ying Li, Ning Wang, Xiao-Hui Zhang, and Yi Ren
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Ecology ,Plant Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2022
26. Impaired lung function related to microenvironmental exposure to PAHs mixture in PM2.5: A repeated measurement study
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Guiyang Wang, Juan Cheng, Lin Wang, Jian Hou, Jing Yuan, Wenjun Yin, Tian Xu, and Qing-qing Zhu
- Subjects
Atmospheric Science ,Vital capacity ,Fine particulate ,Negative association ,Phenanthrene ,complex mixtures ,Pollution ,chemistry.chemical_compound ,FEV1/FVC ratio ,chemistry ,Measurement study ,Environmental chemistry ,Environmental science ,Pyrene ,Waste Management and Disposal ,Lung function - Abstract
Personal exposure to fine particulate matter (PM2.5)-bound polycyclic aromatic hydrocarbons (PAHs) can cause serious adverse health effects. However, limited information is available on the impact of a mixture of PAHs in air-borne PM2.5 on lung function. We conducted a repeated-measures pilot study for four seasons during the period of 2014–2015, monitored the concentrations of 13 PAHs in PM2.5 samples from the outdoor and indoor microenvironments using a gas chromatograph-mass spectrometry, estimated inhaled dose of PM2.5-bound PAHs based on the outdoor and indoor PM2.5-bound PAHs concentrations as well as individual time-activity diary, and analyzed independent and joint effects of PM2.5-bound 13 PAHs on lung function by linear mixed effect (LME) and Bayesian kernel machine regression (BKMR) models, respectively. LME models indicated the negative association of phenanthrene or benzo[a]pyrene with forced expiratory volume in 1 s (FEV1) or forced vital capacity (FVC) in warm season. BKMR models revealed that an overall negative association of the mixture of 13 PAHs in PM2.5 with FVC, FEV1, PEF or MVV values in warm season but only overall negative association of the mixture of 13 PAHs in PM2.5 with MVV values in cold season. In warm season, young adults with higher exposure to certain PAHs or the mixture of 13 PAHs in PM2.5 showed significant impairment in lung function, implying that health risk assessment of the mixture of PAHs in PM2.5 attributed to PM2.5 from traffic emission.
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- 2022
27. Epidemiological characteristics of pulmonary tuberculosis in Anhui Province, Eastern China from 2013 to 2018
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Xun-Di Bao, Fang-Jin Bao, Ze-Kun Zhang, Qing-Qing Zhu, Jun-Wei Yan, Song Yao, Xue-Hui Fang, Ling Li, Rong Wang, Ai-Min Wang, Qian Wu, Yong-Zhong Zhang, Hai-Feng Pan, and Jie Liu
- Subjects
Male ,Bacterial Diseases ,0301 basic medicine ,Epidemiology ,Social Sciences ,Geographical Locations ,Medical Conditions ,0302 clinical medicine ,Medicine and Health Sciences ,Medicine ,030212 general & internal medicine ,Young adult ,Child ,Multidisciplinary ,Geography ,Incidence ,Incidence (epidemiology) ,Respiratory disease ,Age Factors ,Middle Aged ,Actinobacteria ,Infectious Diseases ,Research Design ,Child, Preschool ,Female ,Research Article ,Adult ,China ,medicine.medical_specialty ,Asia ,Tuberculosis ,Adolescent ,Science ,030106 microbiology ,Human Geography ,Research and Analysis Methods ,Infectious Disease Epidemiology ,Urban Geography ,Young Adult ,03 medical and health sciences ,Sex Factors ,Pulmonary tuberculosis ,Humans ,Cities ,Tuberculosis, Pulmonary ,Aged ,Retrospective Studies ,Bacteria ,business.industry ,Organisms ,Infant ,Biology and Life Sciences ,Retrospective cohort study ,Tropical Diseases ,medicine.disease ,People and Places ,Earth Sciences ,business ,Mycobacterium Tuberculosis ,Demography - Abstract
ObjectivePulmonary tuberculosis (TB) is a severe infectious respiratory disease, the burden of which remains high in China. To provide scientific evidence for developing more targeted prevention and control strategies, this study aimed to determine the incidence trends and explore the epidemiological characteristics of pulmonary TB in Anhui Province, Eastern China between 2013 and 2018.MethodsThe retrospective study analyzed information regarding pulmonary TB cases reported by the National Infectious Disease Reporting System and census data collected from the Anhui Provincial Bureau of Statistics.ResultsOverall, 211,892 cases of TB patients were reported in Anhui Province, China between 2013 and 2018, with an average annual reported incidence rate of 57.7 per 100,000 persons. A significant decrease in the incidence rate of pulmonary TB (p < 0.001) was observed during the study period. Men had a higher incidence rate of pulmonary TB than women (p < 0.001). The highest annual average reported incidence rate was 204.2 per 100,000 persons in those aged 70-74 years. The number of farmers with pulmonary TB, i.e., 155,415, accounted for 73.4% of all cases. Moreover, the peak period of reported cases was from January to March. Four cities along the Yangtze River-Anqing, Tongling, Chizhou, and Wuhu-reported significantly higher incidence rates of pulmonary TB than other cities (p < 0.001).ConclusionsFrom 2013 to 2018, there was a significant decline in the incidence rate of pulmonary TB in Anhui Province, with peaks occurring from January to March. Prevention and control strategies targeting men, people aged 70-74 years, farmers, and the four cities along the Yangtze River should be strengthened.
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- 2020
28. Non-linear dose-response relation between urinary levels of nicotine and its metabolites and cognitive impairment among an elderly population in China
- Author
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Erwei Gao, Jing Yuan, Kaiwu He, Lulin Nie, Shaoyou Lu, Fang Ye, Feiqi Zhu, Lu Wang, Ya-jun Yue, Wei Liu, Jianjun Liu, Tian Li, Qing-qing Zhu, Xifei Yang, Li Liu, Li Zhou, Bo Zhu, Lin Wang, and Jiafei Zhang
- Subjects
medicine.medical_specialty ,Passive smoking ,Dose-response relationship ,Health, Toxicology and Mutagenesis ,Urinary system ,Mini-Cog test ,Disease ,medicine.disease_cause ,Environmental pollution ,Tobacco smoke ,Nicotine ,Internal medicine ,Conditional logistic regression ,medicine ,GE1-350 ,Stroke ,business.industry ,Public Health, Environmental and Occupational Health ,Cognition ,General Medicine ,medicine.disease ,Pollution ,Nicotine exposure ,Environmental sciences ,TD172-193.5 ,Tobacco smoke exposure ,Cohort ,business ,medicine.drug - Abstract
Background Active smoking and exposure to environmental tobacco smoke may be related to cognitive function decline. We assessed the associations of urinary levels of nicotine and its metabolites with cognitive function. Methods A total of 553 elder adults at high risk of cognitive impairment and 2212 gender- and age-matched individuals at low risk of cognitive impairment were selected at a ratio of 1: 4 from the remained individuals (n = 6771) who completed the baseline survey of the Shenzhen Ageing-Related Disorder Cohort, after excluding those with either Alzheimer’s disease, Parkinson’s syndrome or stroke as well as those with missing data on variables (including active and passive smoking status, Mini-Cog score). Urinary levels of nicotine and its metabolites and cognitive function for all individuals were measured by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) and assessed using the Mini-Cog test, respectively. Associations of urinary levels of nicotine and its metabolites with cognitive function were analyzed by conditional logistic regression models. Results Individuals in the highest tertile of urinary OHCotGluc (OR: 1.52, 95%CI: 1.19–1.93) or NNO (OR: 1.50, 95%CI: 1.16–1.93) levels as well as in the second tertile of urinary ∑Nic level (OR: 1.43, 95%CI: 1.13–1.82) were at higher risk of cognitive impairment compared with those in the corresponding lowest tertile. Restricted cubic spline models revealed the non-linear dose-response relationships between urinary levels of OHCotGluc, NNO or ∑Nic and the risk of cognitive impairment. Conclusions Urinary levels of OHCotGluc, NNO or ∑Nic exhibited a non-linear dose-response relationship with cognitive function in the urban elderly.
- Published
- 2021
29. Rapid Separation and Determination of 12 Kinds Phenolic Acids and Isoflavone in Iris Pseudoacorus Based on Ultra-performance Convergence Chromatography
- Author
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Qing-Qing, Zhu, primary, Nian-Lai, Chen, additional, Run, CHU, additional, and Qiang-Qiang, Miao, additional
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- 2019
- Full Text
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30. Percutaneous intervention versus coronary artery bypass graft surgery in left main coronary artery stenosis: a systematic review and meta-analysis
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Qing-Qing Zhu, Yang Li, Biao Xu, Lina Kang, Suhui Zhu, Jing-Jing Yang, Jun Xie, Yuhan Chen, Lian Wang, and Xinlin Zhang
- Subjects
medicine.medical_specialty ,Left main coronary artery disease ,medicine.medical_treatment ,Myocardial Infarction ,lcsh:Medicine ,Left Main Coronary Artery Stenosis ,Coronary Artery Disease ,Coronary artery bypass graft surgery ,030204 cardiovascular system & hematology ,Revascularization ,Percutaneous coronary intervention ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Myocardial infarction ,cardiovascular diseases ,Coronary Artery Bypass ,Stroke ,Proportional Hazards Models ,business.industry ,Incidence ,Matched observational studies ,Hazard ratio ,lcsh:R ,Coronary Stenosis ,Stent ,Drug-Eluting Stents ,General Medicine ,medicine.disease ,Surgery ,Meta-analysis ,Treatment Outcome ,Conventional PCI ,Cardiology ,Randomized controlled trials ,business ,Research Article - Abstract
Background The optimal revascularization technique in patients with left main coronary artery disease (CAD) remains controversial. We aimed to compare the long-term performance of percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) surgery in treatment of left main CAD. Methods PubMed, EMBASE, and the Cochrane Library were searched until November 16, 2016. Results Six randomized controlled trials and 22 matched observational studies including 22,487 patients and 90,167 patient-years of follow-up were included. PCI was associated with an overall higher risk for the major adverse cardiac and cerebrovascular events (hazard ratio (HR), 1.42; 95% confidence interval (CI), 1.14–1.77), mainly driven by higher rates of myocardial infarction (HR, 1.69; 95% CI, 1.22–2.34) and revascularization (HR, 2.80; 95% CI, 1.86–4.22). The overall risks for all-cause death (HR, 1.05; 95% CI, 0.93–1.20), cardiac death (HR, 1.05; 95% CI, 0.69–1.59), stroke (HR, 0.64; 95% CI, 0.33–1.24), and the composite safety endpoint of death, myocardial infarction, or stroke (HR, 1.06; 95% CI, 0.97–1.16) were similar between PCI and CABG. Stratified analysis based on stent types showed that the increased risk for myocardial infarction associated with PCI was only evident in patients with bare-metal stents or early-generation drug-eluting stents (DES), but not newer-generation DES. Stratified analyses based on study designs showed largely similar findings with the overall analyses, except for a significantly higher incidence of myocardial infarction in adjusted studies (HR, 2.01; 95% CI, 1.64–2.45) but a trend toward higher incidence in randomized trials (HR, 1.39; 95% CI, 0.85–2.27) associated with PCI. Conclusions Compared with CABG, PCI with newer-generation DES might be a safe alternative revascularization strategy for treatment of left main CAD, but is associated with more repeat revascularization. Electronic supplementary material The online version of this article (doi:10.1186/s12916-017-0853-1) contains supplementary material, which is available to authorized users.
- Published
- 2017
31. Identification of plasma SAA2 as a candidate biomarker for the detection and surveillance of non-small cell lung cancer.
- Author
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Fa-Fu ZHANG, Bin HAN, Run-Hao XU, Qing-Qing ZHU, Qi-Qi WU, Hui-Min WEI, Zhi-Lei CUI, Shu-Lin ZHANG, and Min-Jie MENG
- Subjects
BIOMARKERS ,NON-small-cell lung carcinoma ,IMMUNOHISTOCHEMISTRY ,GENE expression ,ADENOCARCINOMA - Abstract
This study aimed to measure the expression of SAA2 in plasma and to assess its diagnostic efficacy as a biomarker for non-small cell lung cancer (NSCLC). The gene expression of SAA2 in NSCLC was analyzed based on a database. Then, SAA2 expression was detected by immunohistochemistry in lung tissue and by enzyme-linked immunosorbent assay in 90 patients with NSCLC and 61 normal controls. Finally, the diagnostic performance was assessed in terms of accuracy, sensitivity, and specificity. At the gene and protein levels, the SAA2 expression was significantly higher in the NSCLC group than in the control group (p<0.01). It was higher in lung squamous carcinoma than in lung adenocarcinoma and in males than in females, and this trend was also observed in the lung squamous carcinoma group. Of note, the expression of SAA2 increased with increasing disease stage. Receiver operating characteristic (ROC) curve analysis revealed that the sensitivity of SAA2 was 83.61%, the specificity was 91.11%, and the area under the curve (AUC) was 0.9252. Its accuracy was 68.89%, which was higher than that of other conventional diagnostic biomarkers, and the combined application can effectively improve the diagnostic efficiency. Based on the results, SAA2 expression was positively correlated with the disease stage of NSCLC. Notably, SAA2 is more concerning in male patients with lung squamous carcinoma, and it can help in the screening and diagnosis of NSCLC. SAA2 may represent a novel diagnostic biomarker in NSCLC. [ABSTRACT FROM AUTHOR]
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- 2021
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32. Glutathione S-transferase mu-1, glutathione S-transferase theta-1 null genotypes, and oral cancer risk: A meta-analysis in the Chinese population
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Jie-Yi Li, Li-Na Huang, Cong-Hua Li, Qing-Qing Zhu, and Hong-Lei Xue
- Subjects
0301 basic medicine ,Mainland China ,Oncology ,medicine.medical_specialty ,China ,Taiwan ,lcsh:RC254-282 ,Polymorphism, Single Nucleotide ,polymorphism ,Glutathione S-transferase mu-1 ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Internal medicine ,Genotype ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Genetic Predisposition to Disease ,Glutathione Transferase ,biology ,business.industry ,General Medicine ,Odds ratio ,oral cancer ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Chinese people ,Confidence interval ,meta-analysis ,030104 developmental biology ,Glutathione S-transferase ,Glutathione S-Transferase Mu ,030220 oncology & carcinogenesis ,Meta-analysis ,glutathione S-transferase theta-1 ,biology.protein ,Mouth Neoplasms ,business - Abstract
Aim of Study: Several studies have evaluated the correlation between glutathione S-transferase mu-1 (GSTM1), GST theta-1 (GSTT1) polymorphisms and oral cancer in Chinese people. However, the results are inconsistent. To assess the effects of GSTM1, GSTT1 null genotypes on the risk for development of oral cancer in the Chinese population, a meta-analysis was performed. Materials and Methods: Studies were identified using PubMed and Chinese databases through February 2016. The associations were assessed with pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results: This meta-analysis included six studies with 1306 oral cancer cases and 1484 controls. In the overall analysis, no significant association between GSTM1, GSTT1 polymorphisms and oral cancer was found in the Chinese population. In the subgroup analyses by geographic areas and source of controls, significant risk was found between GSTM1 null genotype and oral cancer in Mainland China (OR = 2.715, 95% CI = 2.17–3.38), but not in Taiwan China. Conclusion: Our meta-analysis suggested that GSTM1 null genotype might be associated with an increased risk of developing oral cancer in individuals from Mainland China.
- Published
- 2018
33. Influence of heat treatment on the structure and core IgE-binding epitopes of rAra h 2.02
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Qing-qing Zhu, Wen-ju Zhang, Qin Cai, and Qin Chen
- Subjects
0301 basic medicine ,Indirect elisa ,Circular dichroism ,Hot Temperature ,Ige binding epitopes ,Microscopy, Atomic Force ,Epitope ,Analytical Chemistry ,Epitopes ,03 medical and health sciences ,0404 agricultural biotechnology ,Glycoproteins ,biology ,Chemistry ,Atomic force microscopy ,04 agricultural and veterinary sciences ,General Medicine ,Antigens, Plant ,Immunoglobulin E ,040401 food science ,Molecular biology ,Recombinant Proteins ,Blot ,030104 developmental biology ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,biology.protein ,Antibody ,2S Albumins, Plant ,Food Science - Abstract
The rAra h 2.02 was studied to determine the influence of heat treatment on its structure and core IgE-binding epitopes. The results of SDS-PAGE, Western blotting, MALDI-TOF-MS, and atomic force microscopy showed that the structure of rAra h 2.02 was altered after boiling (100°C) or autoclaving (121°C) for 20min. Furthermore, some of the protein may be aggregated. Results of circular dichroism spectroscopy showed that the α-helices content was reduced, while β-turns and random coils were increased by 81% and 27%, respectively, after autoclaving. Antibodies of three core IgE-binding epitopes were used to determine the binding capacity of rAra h 2.02 after thermal processing by indirect ELISA. The results showed that the binding capacities of the three core IgE-binding epitopes were changed after different heat treatments.
- Published
- 2016
34. Study design and baseline characteristics of Shenzhen ageing-related disorder cohort in China
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Weimin Liu, Zhiwei Guo, Xingchen Yu, Jing Yuan, Li Liu, Qing-qing Zhu, Yidan Huang, Fang Ye, Xian Wang, Erwei Gao, Kaiwu He, Weihong Chen, Yi Luo, Lu Wang, Jianjun Liu, Jiafei Zhang, Chunjie Yuan, Lulin Nie, Li Zhou, Feiqi Zhu, Wei Liu, and Tian Li
- Subjects
Male ,Aging ,China ,lifestyle ,Pediatrics ,medicine.medical_specialty ,Chronic bronchitis ,Epidemiology ,aging related disorders ,environmental exposure ,lcsh:Medicine ,Overweight ,Cohort Studies ,Alzheimer Disease ,cohort study ,medicine ,Humans ,Cognitive Dysfunction ,Obesity ,neurological disease ,Family history ,Noncommunicable Diseases ,Prospective cohort study ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,Depression ,business.industry ,Arthritis ,lcsh:R ,Parkinson Disease ,General Medicine ,Environmental exposure ,Middle Aged ,Brain Injuries ,Cohort ,Female ,medicine.symptom ,business ,genetic susceptibility ,Cohort study - Abstract
PurposeThe Shenzhen ageing-related disorder cohort was designed to detect the associations of lifestyle, environmental and genetic factors with major ageing-related disorders, especially neurological and mental disorders.ParticipantsThe cohort was a community-dwelling prospective study of 9411 elderly adults aged 60 to 92 years from 51 community health service centres in Luohu district of Shenzhen, China. The baseline data were collected between 2017 and 2018, including demographics and socioeconomics, lifestyles, medical history, family history of major non-communicable chronic disease, environmental exposures, clinical analysis of blood and urine, clinical imaging measurements, anthropometric measures and neurological function and mental health assessments. Blood and urinary samples were collected at baseline. All participants will be followed for physiological and psychological disorders and updated lifestyle and environmental exposures every 5 years.Findings to dateThe mean age of the participants was 67.73 years at baseline, and 42.74% were males. The prevalences of individuals with unhealthy conditions were as follows: overweight/obesity (54.38%), hypertension (58.24%), diabetes mellitus (22.30%), dyslipidaemia (75.69%), chronic bronchitis (1.45%), myocardial infarction (0.55%), coronary heart disease (5.69%), stroke (1.10%), cancer (2.18%), arthritis (5.04%), Alzheimer’s disease (0.18%), Parkinson’s disease (0.23%), brain injury (5.75%), cognitive impairment (5.39%) and depression status (3.28%). The mean scores for the Lawton-Brody Activities of Daily Living Scale and the Social Support Rate Scale were 14.15 and 39.54, respectively.Future plans2000 new entrants from Luohu district will be recruited every year until 2028. The data collection is expected to be ended at the end of 2030. The data will be used to assess the causality of ageing-related disorders, especially neurological and mental disorders through integrating environmental, genetic and lifestyle factors. The data sets generated and/or analysed during the current study are not publicly available at this stage, but are available from the corresponding author on reasonable request.
- Published
- 2020
35. Associations of a mixture of urinary phthalate metabolites with blood lipid traits: A repeated-measures pilot study
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Qing-qing Zhu, Zhiqiang Yu, Jing Yuan, Lin Wang, Wenjun Yin, Juan Cheng, Jian Hou, Tian Xu, and Fang Ye
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Male ,China ,010504 meteorology & atmospheric sciences ,Health, Toxicology and Mutagenesis ,Urinary system ,Phthalic Acids ,Physiology ,Blood lipids ,Pilot Projects ,Phthalate metabolite ,Urine ,010501 environmental sciences ,Biology ,Toxicology ,Hydrocarbons, Aromatic ,01 natural sciences ,chemistry.chemical_compound ,Urinary levels ,Diethylhexyl Phthalate ,Humans ,Chromatography, High Pressure Liquid ,0105 earth and related environmental sciences ,Phthalate ,Repeated measures design ,Bayes Theorem ,Lipid metabolism ,Environmental Exposure ,General Medicine ,Middle Aged ,Lipids ,Pollution ,chemistry ,Linear Models ,Female ,lipids (amino acids, peptides, and proteins) - Abstract
Evidence is available about the associations of phthalates or their metabolites with blood lipids, however, the mixture effects of multiple phthalate metabolites on blood lipid traits remain largely unknown. In this pilot study, 106 individuals at three age groups of
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- 2020
36. The role and clinical significance of programmed cell death- ligand 1 expressed on CD19
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Xiao-Yun, Jia, Qing-Qing, Zhu, Yuan-Yuan, Wang, Yang, Lu, Zhi-Jun, Li, Bai-Qing, Li, Jie, Tang, Hong-Tao, Wang, Chuan-Wang, Song, Chang-Hao, Xie, and Lin-Jie, Chen
- Subjects
Adult ,Male ,B-Lymphocytes ,Immunoglobulin G ,Antigens, CD19 ,Humans ,Lupus Erythematosus, Systemic ,Female ,DNA ,T-Lymphocytes, Helper-Inducer ,Middle Aged ,B7-H1 Antigen - Abstract
Programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD-L1)-targeted therapies have enhanced T-cell response and demonstrated efficacy in the treatment of multiple cancers. However, the role and clinical significance of PD-L1 expression on CD19The present study aimed to investigate PD-L1 expression on CD19+ B-cells and their subsets, in addition to exploring its possible role in Tfh-cell activation and B-cell differentiation in SLE.Frequencies of CD19In SLE patients, CD19This study demonstrated that the expression of CD19
- Published
- 2018
37. Cardiovascular Safety, Long‐Term Noncardiovascular Safety, and Efficacy of Sodium–Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Systemic Review and Meta‐Analysis With Trial Sequential Analysis
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Qing-Qing Zhu, Xueling Li, Xinlin Zhang, Jian‐An Huang, Yuhan Chen, Fu Chen, and Biao Xu
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Kidney ,Risk Assessment ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Sodium-Glucose Transporter 2 ,Randomized controlled trial ,cardiovascular disease ,Risk Factors ,law ,Internal medicine ,medicine ,Humans ,Diabetic Nephropathies ,In patient ,030212 general & internal medicine ,Sodium-Glucose Transporter 2 Inhibitors ,Randomized Controlled Trials as Topic ,Systematic Review and Meta‐Analysis ,Cardiovascular safety ,business.industry ,Meta Analysis ,Diabetes, Type 2 ,Type 2 Diabetes Mellitus ,Middle Aged ,Protective Factors ,Observational Studies as Topic ,Metabolism ,Treatment Outcome ,Diabetes Mellitus, Type 2 ,meta‐analysis ,Cardiovascular Diseases ,Meta-analysis ,Sodium/Glucose Cotransporter 2 ,randomized controlled trial ,SGLT2 (sodium–glucose cotransporter 2) inhibitor ,observational study ,Female ,Observational study ,Patient Safety ,Cardiology and Cardiovascular Medicine ,business ,Cotransporter ,trial sequential analysis - Abstract
Background The cardiovascular and long‐term noncardiovascular safety and efficacy of SGLT 2 (sodium–glucose cotransporter 2) inhibitors have not been well documented. Methods and Results For cardiovascular outcomes, we performed a meta‐analysis with trial sequential analysis of randomized controlled trials and adjusted observational studies, each with a minimum of 26 weeks and 2000 patient‐years of follow‐up. For long‐term noncardiovascular safety and efficacy outcome analyses, we included only randomized controlled trials with at least 2 years and 1000 patient‐years of follow‐up. Five studies with 351 476 patients were included in cardiovascular outcomes analysis. Meta‐analyses showed that SGLT 2 inhibitors significantly reduced the risks of major adverse cardiac events (hazard ratio [ HR ]: 0.80; 95% confidence interval [ CI ], 0.69–0.92; P =0.002), all‐cause mortality ( HR : 0.67; 95% CI , 0.54–0.84; P HR : 0.77; 95% CI, 0.60–0.98; P =0.03), nonfatal myocardial infarction ( HR : 0.86; 95% CI , 0.76–0.98; P =0.02), hospitalization for heart failure ( HR : 0.62; 95% CI , 0.55–0.69; P HR : 0.68; 95% CI , 0.58–0.81; P SGLT 2 inhibitors, but evidence remains inconclusive for cardiovascular mortality. Nine randomized controlled trials contributed to long‐term noncardiovascular and efficacy analyses. SGLT 2 inhibitors reduced incidence of hypoglycemia and acute kidney injury but increased the risks of urinary tract and genital infections. Conclusions SGLT 2 inhibitors showed remarkable cardiovascular‐ and renal‐protective effects and good long‐term noncardiovascular safety with sustained efficacy.
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- 2018
38. Mid- and Long-Term Outcome Comparisons of Everolimus-Eluting Bioresorbable Scaffolds Versus Everolimus-Eluting Metallic Stents: A Systematic Review and Meta-analysis
- Author
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Qing-Qing Zhu, Xue-Ling Li, Li-Na Kang, Biao Xu, and Xin-Lin Zhang
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Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Coronary Disease ,030204 cardiovascular system & hematology ,Revascularization ,Prosthesis Design ,law.invention ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Percutaneous Coronary Intervention ,Randomized controlled trial ,law ,Risk Factors ,Internal medicine ,Absorbable Implants ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Myocardial infarction ,Everolimus ,business.industry ,Incidence ,Percutaneous coronary intervention ,Drug-Eluting Stents ,Thrombosis ,General Medicine ,Odds ratio ,medicine.disease ,Cardiology ,business ,medicine.drug - Abstract
Background Percutaneous coronary interventions to implant bioresorbable vascular scaffolds (BVSs) were designed to reduce the late thrombotic events that occur with metallic stents. Purpose To estimate the incidence of scaffold thrombosis after BVS implantation and compare everolimus-eluting BVSs with everolimus-eluting metallic stents (EESs) in terms of safety and efficacy at mid- and long-term follow-up in adults who had a percutaneous coronary intervention. Data sources PubMed, EMBASE, the Cochrane Library, conference proceedings, and relevant Web sites from inception until 20 May 2017, without language restriction. Study selection 7 randomized trials and 38 observational studies (each with a minimum of 6 months and 100 patient-years of follow-up) in adults with coronary artery disease who had a BVS or an EES and reported scaffold or stent thrombosis (main outcome) or other secondary outcomes (such as death, myocardial infarction, or revascularization). Data extraction 2 reviewers independently extracted study data, rated study quality, and assessed strength of evidence. Data synthesis The pooled incidence of definite or probable scaffold thrombosis after BVS implantation was 1.8% (95% CI, 1.5% to 2.2%) at a median follow-up of 1 year (41 studies, 21 884 patients) and 0.8% (CI, 0.5% to 1.3%) beyond 1 year (14 studies, 4688 patients). Seven trials involving 5578 patients that directly compared BVSs with EESs showed an increased risk for definite or probable scaffold thrombosis (odds ratio [OR], 3.40 [CI, 2.01 to 5.76]) with BVSs at a median follow-up of 25 months. Increased risks were present at early (prominently subacute), late, and very late stages, and odds beyond 1 year were almost double those seen within 1 year. Bioresorbably vascular scaffolds increased risks for myocardial infarction (OR, 1.63 [CI, 1.26 to 2.10]), target lesion revascularization (OR, 1.31 [CI, 1.03 to 1.67]), and target lesion failure (OR, 1.37 [CI, 1.12 to 1.66]); the odds for these 3 end points also increased over time. The incidences of all-cause, cardiac, and noncardiac death and of target vessel and any revascularization did not differ. Limitation Quality of observational studies was unclear, and some data were unpublished. Conclusion Compared with EESs, BVSs increased the risks for scaffold thrombosis and other thrombotic events at mid- and long-term follow-up, and risks increased over time. Primary funding source National Natural Science Foundation of China.
- Published
- 2017
39. Optimize the duration of DAPT following DES implantation: An updated system review and meta-analysis of 10 randomized trials
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Qing-Qing Zhu, Jianzhou Chen, Li Zhu, Xinlin Zhang, Wei Huang, Biao Xu, Jun Xie, and Su-Qin Shi
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lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,animal structures ,Thienopyridine ,medicine.medical_treatment ,Percutaneous coronary intervention ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,Antithrombotic ,medicine ,Drug-eluting stents ,Aspirin ,business.industry ,Randomized trials ,Surgery ,Meta-analysis ,lcsh:RC666-701 ,Dual antiplatelet therapy ,Conventional PCI ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Major bleeding ,medicine.drug - Abstract
Background: The appropriate duration of dual antiplatelet therapy (DAPT) with aspirin and a thienopyridine following drug-eluting stenting in percutaneous coronary intervention (PCI) remains uncertain. Methods and results: A systemic search was conducted in PubMed, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL), for randomized trials evaluating the relative efficacy and safety performance of an extended with a control duration DAPT after drug-eluting stents (DES) implantation. Ten trials including 32,135 patients were included. Compared with DAPT of 3 to 6 months, an extended DAPT duration of 12 months or longer significantly increased risk of major bleeding by 90% (RR: 1.90, 95% CI: 1.23 to 2.94, p = 0.004), but did not reduced incidences of any documented ischemic events. Compared with 12-month duration, a more extended DAPT (18 to 30 months) significantly increased risk of all-cause death (RR: 1.30, 95% CI: 1.02 to 1.65, p = 0.035) and major bleeding (RR: 1.61, 95% CI: 1.25 to 2.07, p
- Published
- 2015
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40. Application of Grouting Technology in the Geotechnical Engineering
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Qing Qing Zhu, Shu Ping Jiang, and Qiang Qiang Miao
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Engineering ,business.industry ,Geotechnical engineering ,General Medicine ,business ,Civil engineering - Abstract
Through detailed investigation to development status of grouting technique, summarizes the classification of geotechnical grouting technology, selection of materials grouting, Finally, by anchoring engineering and tunneling engineering described in detail grouting process,grouting order, grouting parameters and grouting end standard in the geotechnical engineering application,This research has practical guidance and theoretical reference value for similar projects.
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- 2015
41. Research of High Voltage Electrostatic Filter Composite Horizontal Collector Exclusive Filter Material
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Qiang Qiang Miao and Qing Qing Zhu
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Engineering ,business.industry ,Composite number ,Electrical engineering ,Mechanical engineering ,High voltage ,General Medicine ,law.invention ,law ,Filter (video) ,Dust collector ,Service life ,Investment cost ,business ,Air filter ,Filter material - Abstract
We selected a typical filter material for high voltage electrostatic filter composite horizontal collector. Air filter can achieve high speed. It cost very low and can endure high temperature resistance. Removal of fine particles of dust effect is good. Solving the complex problems of higher smoke temperature conditions of traditional bag house can not handle, while reducing the dust collector investment cost, promote the development of China's dust remover industry.
- Published
- 2015
42. Chemoenzymatic enantioconvergent hydrolysis of p-nitrostyrene oxide into (R)-p-nitrophenyl glycol by a newly cloned epoxide hydrolase VrEH2 from Vigna radiata
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Li-Qiang Fan, Jian-He Xu, Xu-Dong Kong, Yan-Wen Wu, and Qing-Qing Zhu
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biology ,Stereochemistry ,Chemistry ,Process Chemistry and Technology ,Regioselectivity ,General Chemistry ,biology.organism_classification ,Catalysis ,Vigna ,Hydrolysis ,chemistry.chemical_compound ,Enantiopure drug ,Biocatalysis ,Organic synthesis ,Epoxide hydrolase - Abstract
An epoxide hydrolase from Vigna radiata, VrEH2, was successfully cloned and overexpressed in Escherichia coli. Its temperature and pH optima were 30 °C and 6.5, respectively. VrEH2 showed an opposite regioselectivity towards (S)- and (R)-para-nitrostyrene oxide (pNSO), which enables it to catalyze the enantioconvergent hydrolysis of rac-pNSO affording (R)-p-nitrophenyl glycol (pNPG). Preparative synthesis of (R)-pNPG from rac-pNSO by a chemoenzymatic enantioconvergent hydrolysis route with one quarter time as using VrEH2 alone, gave (R)-pNPG in 99.0% ee and 71.5% overall yield after recrystallization, indicating the potential of VrEH2 as a promising biocatalyst for the preparation of enantiopure diols in organic synthesis.
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- 2015
43. Topological Map Building Based on Thinning
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Qing Qing Zhu, Hai Yan Wang, and Na Wang
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Quasi-open map ,Thinning ,business.industry ,Mobile robot ,General Medicine ,Grid reference ,Key (cryptography) ,Computer vision ,Artificial intelligence ,Motion planning ,Topological map ,Voronoi diagram ,business ,Algorithm ,Mathematics - Abstract
In order to accomplish navigation and path planning, map building is the key technology and fundamental problem in mobile robotic control in unknown environment. In this paper the topological map is built based on the grid map by using a thinning algorithm. The environment is modeled in grid map, next the thinning algorithm is applied in the map, and then the effective topological information is extracted. Simulation results show that the topological map based on thinning is clear and succinct, and it also avoids producing unnecessary nodes and paths. This topological map stores much less information which will improve the ability of autonomous operation, navigation and path planning further.
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- 2014
44. Public-private Partnership (PPP): Service Model Innovation for Entry-exit Inspection and Quarantine Bureau in China
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Qing-qing Zhu and Zheng He
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Finance ,Government ,business.industry ,Certificate ,law.invention ,Personalization ,Public–private partnership ,law ,General partnership ,Quarantine ,Production (economics) ,Operations management ,China ,business - Abstract
Under transitional economy how to improve the performance of public administration has become an urgent problem for Chinese government. The China Entry-exit Inspection and Quarantine Bureau (CIQ) is a specialized official department that is responsible for various inspections, quarantine and related managerial activities for import-export products as well as persons and provides the corresponding inspection and quarantine certificate according to government regulations and international rules. In the paper, taking Guizhou Entry-exit Inspection and Quarantine Bureau as a case, we explore how to establish new service model to provide better and more efficient services to the import-and-export enterprises. According to the results of field survey, this paper suggests that entry-exit inspection and quarantine center should be set up to provide more value-added and customization services in which Public-Private Partnership (PPP) model can be employed to integrate the inspection activities into production processes.
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- 2017
45. Role of downregulated miR-133a-3p expression in bladder cancer: a bioinformatics study
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Gang Chen, Sheng-Hua Li, Qing-Qing Zhu, Yu-Yan Pang, Xiaohua Hu, Li Gao, and Yi-Xin Tian
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0301 basic medicine ,Biology ,Bioinformatics ,OncoTargets and Therapy ,law.invention ,miR-133a-3p ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,law ,medicine ,Pharmacology (medical) ,KEGG ,Gene ,Original Research ,bioinformatics study ,Bladder cancer ,medicine.disease ,target genes ,Biomarker (cell) ,meta-analysis ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Suppressor ,Mir 133a ,bladder cancer ,Function (biology) - Abstract
Li Gao,1,* Sheng-Hua Li,2,* Yi-Xin Tian,1 Qing-Qing Zhu,1 Gang Chen,3 Yu-Yan Pang,3 Xiao-Hua Hu1 1Department of Medical Oncology, 2Department of Urology Surgery, 3Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China *These authors contributed equally to this work Abstract: It has been discovered that miR-133a-3p acts as a tumor suppressor in bladder cancer (BC). Nevertheless, the function of miR-133a-3p in BC remains unclarified. Thus, we carried out this study to validate the expression of miR-133a-3p in BC and provide insights into the molecular mechanism underlying it. To assess the expression of miR-133a-3p in BC, we searched eligible studies from literature and Gene expression Omnibus (GEO) to perform a meta-analysis. We also plotted the summary receiver operating characteristic (SROC) curve to evaluate the diagnostic ability of miR-133a-3p in BC. Additionally, the potential target genes of miR-133a-3p were acquired from 14 online software programs and GEO database. Protein-protein interaction (PPI) network was created to identify the hub genes. Then, Gene Ontology (GO) functional annotation analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were carried out to investigate the regulatory network of the target genes. From the meta-analysis, miR-133a-3p was remarkably downregulated in BC tissues compared with that in non-cancer tissues (standard mean difference =-3.84, 95% confidence interval=-6.99–0.29). Moreover, results from SROC suggested that miR-133a-3p exhibited the ability to diagnose BC (area under curve =0.8418). As for the bioinformatics study, 488 genes were chosen as the potential targets of miR-133a-3p in BC, among which 10 genes were defined as hub genes (all degrees >5). Further GO and KEGG pathway analysis indicated that the target genes of miR-133a-3p aggregated in specific biological process and pathways. In conclusion, miR-133a-3p possessed great diagnostic potential with its downregulation in BC, and miR-133a-3p might serve as a novel biomarker for BC. Keywords: bladder cancer, target genes, miR-133a-3p, meta-analysis, bioinformatics study 
- Published
- 2017
46. Research on the changes in wettability of rice (Oryza sativa .) leaf surfaces at different development stages using the OWRK method
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Feng-pei Du, Lu Zhou, Yu Li, Qing-qing Zhu, Ting-ting Yu, Chun-xin Yu, Chong Cao, and Yan-qiu Zhu
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Oryza sativa ,Chemistry ,fungi ,Significant difference ,food and beverages ,Rice growth ,General Medicine ,Surface energy ,Contact angle ,Surface tension ,Horticulture ,Agronomy ,Insect Science ,Cultivar ,Wetting ,Agronomy and Crop Science - Abstract
BACKGROUND A good knowledge in wetting behavior of pesticide spray liquid on plant surface is crucial to spray applications. Difference in leaf surface wettability would result in obvious changes in spray wetting behavior. The aim of this paper is to obtain the changes of wettability during different growth periods. RESULTS The contact angle (CA) of rice leaf for each liquid increased with rice growth. No significant difference was found between cultivars. The CA was found to be correlated with the polar component of liquid surface tension. The square of the polar component was also found to be highly significant indicating that the relationship between these two properties was not a simple linear one. The surface energy of each plant surface decreased as the plants aged. This was also true of each part of the surface energy. However, no obvious difference on the proportion of the components was found among different cultivars and stages. CONCLUSIONS The changes in value of CA and surface free energy (SFE) both reflect the changes of the leaf surface wettability, while the SFE value shows better in wettability characterizing. Obvious rice leaf wettability changes were found on different development stages, which may be beneficial for researches in agrochemical sprays wetting and spreading behavior. Factors influencing these alterations were discussed. © 2013 Society of Chemical Industry
- Published
- 2013
47. Introduction of Noncontact Laser Measuring System to Measure Volume Displacement of Triaxia1 Specimens
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Qing Qing Zhu and Qiang Qiang Miao
- Subjects
Materials science ,Position (vector) ,law ,Acoustics ,Volume displacement ,General Engineering ,Measure (physics) ,Geotechnical engineering ,Volume change ,Deformation (meteorology) ,Laser ,Sample (graphics) ,law.invention - Abstract
This paper introduced a measuring soil sample triaxial volume displacement system that used position sensing detector.The system course of principle and development was maken a detailed statement. The study was carried through literature [12] existing shortcomings. The shortcomings of former system was mended in the new system .This system had a high measuring precision and reasonable design. This systems triumphantly developed will be applied in triaxial specimens local sheared and port restriction .This system have greatly applied foreground to study deformation localizing , come into being cut strip and measuring volume change of unsaturated soil.
- Published
- 2013
48. Thermal processing effects on peanut allergen Ara h 2 allergenicity in mice and its antigenic epitope structure
- Author
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Wen-ju Zhang, Qin Chen, Qing-qing Zhu, Qin Cai, and Tong Zhang
- Subjects
0301 basic medicine ,Glycosylation ,Hot Temperature ,Arachis ,Food Handling ,Down-Regulation ,medicine.disease_cause ,Epitope ,Antibodies ,Protein Structure, Secondary ,Analytical Chemistry ,03 medical and health sciences ,Epitopes ,Mice ,0404 agricultural biotechnology ,Protein structure ,Allergen ,Antigen ,Glycation ,Botany ,medicine ,Animals ,Peanut Hypersensitivity ,Inhibitory effect ,Protein secondary structure ,Roasting ,Glycoproteins ,Plant Proteins ,Mice, Inbred BALB C ,030109 nutrition & dietetics ,Chemistry ,Plant Extracts ,Circular Dichroism ,food and beverages ,04 agricultural and veterinary sciences ,General Medicine ,Allergens ,Antigens, Plant ,Immunoglobulin E ,040401 food science ,Protein Structure, Tertiary ,Biochemistry ,Female ,Spectrophotometry, Ultraviolet ,Food Science ,2S Albumins, Plant - Abstract
Ara h 2 was purified from peanuts that were thermally treated by various processes, including boiling, glycation, frying and roasting. The allergenicity of Ara h 2 in Balb/c mice and the influence of thermal processing on the structural characteristics, and binding capacity of three core antigenic epitopes were studied. The results demonstrated that boiling, glycation and frying induced the down-regulation of the allergenicity of Ara h 2 in Balb/c mice, the collapse of its tertiary/secondary structure, and a reduction in the core epitope binding capacity; roasting showed a comparable allergenicity and the weakest inhibitory effect on core epitope binding capacity. These results indicate that thermal processing causes alteration of the protein structure and core epitopes of Ara h 2, and may affect its allergenicity.
- Published
- 2016
49. Expression and Characterization of a Novel Enantioselective Lipase from Aspergillus fumigatus
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Jiao-Jiao Shangguan, Li-Qiang Fan, Qing-Qing Zhu, Jian-He Xu, Fu-Jun Wang, Jian Zhao, and Xin Ju
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Gene Expression ,Bioengineering ,Acetates ,medicine.disease_cause ,Applied Microbiology and Biotechnology ,Biochemistry ,Substrate Specificity ,Aspergillus fumigatus ,Hydrolysis ,chemistry.chemical_compound ,Affinity chromatography ,Enzyme Stability ,Escherichia coli ,medicine ,Protease Inhibitors ,Cloning, Molecular ,Lipase ,Molecular Biology ,Chromatography ,Ethanol ,biology ,Temperature ,Stereoisomerism ,General Medicine ,Hydrogen-Ion Concentration ,Mandelic acid ,biology.organism_classification ,Recombinant Proteins ,chemistry ,Metals ,Solvents ,biology.protein ,Mandelic Acids ,Specific activity ,Plasmids ,Biotechnology - Abstract
A 1,080-bp cDNA (CGMCC 2873) encoding of a cold-active lipase of Aspergillus fumigatus (AFL67) was cloned and expressed in Escherichia coli for the first time. The new lipase, AFL67, was one-step purified by 8.30 folds through Ni-NTA affinity chromatography with a recovery of 86.8 %. The specific activity of purified AFL67 was 449 U mg(-1) on p-NP hexanoate. AFL67 preferentially hydrolyzed p-nitrophenyl esters of short- and medium-chain fatty acids, with p-nitrophenyl hexanoate the maximum. The optimum temperature and pH was 15 °C and 7.5, respectively. The purified AFL67 was stable at 10-25 °C for 30 min, and in the pH range of 6.0-9.0 for 16 h (at 4 °C). Its activity was increased by 47 and 50 %, in the presence of 10 % (v/v) ethanol and isopropanol, respectively. The new lipase AFL67 highly enantioselectively deacylated (S)-α-acetoxyphenylacetic acid (APA) and o-Cl-APA, m-Cl-APA, and p-Cl-APA to (S)-mandelic acid and its derivates. These features render this cold-active novel lipase AFL67 attractive for biotechnological applications in the field of enantioselective synthesis of chiral mandelic acids, o-acylated mandelic acids, and their derivates and detergent additives.
- Published
- 2012
50. Experiment Study on One Dimensional Vertical Soil Pole Seeper Infiltration of Unsaturated Clayey Sand
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Qing Qing Zhu, Zheng Han Chen, Qiang Qiang Miao, Zhi Hua Yao, and Jun Hao Zhang
- Subjects
Infiltration (hydrology) ,Hydraulic head ,High water content ,General Engineering ,Time pass ,Geotechnical engineering ,Water content ,Dry density ,Geology ,Bed load - Abstract
Measuring system of soil moisture and water bedload LGD-Ⅲ was used in those tests . Infiltration law of one dimensional vertical soil poles were carried out profound studies,under different density and a constant water head . At the same time,the course of wetness front along with time pass away, infiltration law along with time pass away and different high water content along with time pass away were made a comprehensive studies , under different dry density. According to a great deal of test data, the relationship between wetness front and time was given to a function under different dry density.
- Published
- 2011
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