Search

Thermo-reactive deposition (TRD) salt bath Nb-Cr co-diffusion process was brought forward to prepare the functionally gradient chromium-niobium carbide coating. In TRD salt bath Nb-Cr co-diffusion treatment, T10 steel samples were delved into TRD salt. The samples were treated at 880°C for 3.5 h and then at 950°C for 2.5h. The obtained coatings were characterized by means of microstructure, microhardness, scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX) and X-ray diffraction analysis (XRD). The cross-section hardness of the chromium-niobium carbide coating obtained on the surface of T10 steel samples transits smoothly. The coating was dense, smooth and compact. The thickness ratio of the niobium carbide layer (the outer layer) and the chromium carbide layer (the inner layer) was 4. The hardness of chromium-niobium carbide coating was about 2751HV0.05, which is between the single chromizing and single niobium. The results showed superior wear properties of the coated samples. The kinetics of chromium-niobium carbide coating was also studied.

End-stage renal disease (ESRD), the last stage of chronic renal failure, is a global health problem. The number of ESRD patients worldwide is increasing faster than the number of kidneys available per year for renal transplantation. Most of the ESRD patients are awaiting renal transplantation. The immune response to the transplanted kidney is directed mainly against mismatched human leukocyte antigen (HLA) glycoproteins expressed on donor tissues. Thus, the analysis of HLA allele and haplotype polymorphisms is valuable not only for identifying ESRD susceptibility factors but also to improve graft survival.In this study, 163 Han ESRD patients were recruited to participate. The blood samples were genotyped by sequence-specific oligonucleotide method. A group of 14,529 healthy Chinese Han individuals registered at the Dalian Blood Center as bone marrow donors, living in the same region and of the same ethnicity, were used as controls.We found that only one allele, HLA-DRB1*12, showed a positive association with ESRD (p = 0.004, pThey were potentially valuable predictors for evaluating the risk of ESRD in the Dalian Han population.

In this paper, a four-storey reinforced concrete frame infilled wall structure does not meet the seismic perform target, based on the seismic behavior target of both frame and infilled wall, to carry out the study on the passive control seismic strengthen of RC infilled wall structure with attached dampers. First, two kinds of passive control strengthen schemes were put forward. Scheme 1: Dampers were installed in the in-plane direction parallel with all 1-storey infilled walls; Scheme 2: Dampers were installed in the in-plane direction parallel with all 1-storey and 2-storey infilled walls. Then to establish the two types of passive control seismic strengthen model in OpenSees, carry out the rare earthquake nonlinear time-history analysis under El Centro, Parkfield and San Fenando ground motions. Finally, in accordance with the seismic performance target quantization index of RC Frame infilled wall structure used as hospital, i.e. considering storey drift ratio limit and infilled wall damage, judge the scheme 2 can meets the seismic performance target.

The seismic damage and even collapse of the infilled walls in RC frame infilled wall structure is the issue that needs thorough study, In this paper, firstly introduces the improved infilled wall model which can consider the interaction of in-plane and out-of-plane, and can judge the damage state of infilled walls, as well as the interaction between RC frame and infilled walls. Then, based on the finite element software OpenSees, under rare earthquake, performed the nonlinear numerical simulation of two finite element models-RC frame without infilled walls and RC frame with infilled walls, comparative analysis differences of both plastic hinge zone’s steel strain, drift and acceleration response, and in-depth study of the infilled walls effect in RC frame infilled wall structure and reason analysis.

Laggera alata extract (LAE) was quantitatively analyzed, and its principle components isochlorogenic acids were isolated and authenticated. Protective properties of LAE were studied using a D-galactosamine (D-GalN)-induced injury model in neonatal rat hepatocytes and a D-GalN-induced acute liver damage model in mice. Meanwhile, the effect of isochlorogenic acids derived from LAE on D-GalN-induced hepatocyte injury were also measured in vitro. LAE at concentrations of 10–100 μg/ml significantly reduced cellular leakage of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and improved cell viability. The isochlorogenic acids (4,5-O-dicaffeoylquinic acid, 3,5-O-dicaffeoylquinic acid and 3,4-O-dicaffeoylquinic acid) at concentrations of 1–100 μg/ml also remarkably improved viability of hepatocytes. The oral treatment of LAE at doses of 50, 100 and 200 mg/kg markedly reduced the serum AST and ALT activity of mice and resulted in significant recovery of hepatocytes in liver sections.

In this paper, a real high-piers bridge was taken as the example, the 3D nonlinear finite element model of this high-pier bridge is built based on OpenSees, then to do the analysis of seismic collision effects of the high-pier bridge under uniform excitation and multi-excitation considering the effect of traveling wave. And analyzing the reaction rule under different ground motions, and focusing on the differences of the effects of seismic pounding between uniform excitation and multi-excitation considering the effect of traveling wave. the seismic responses of high-pier bridge are closely related with its inherent dynamic characteristics and the spectral characteristics of ground motion and closer to the natural cycle of the bridge the main periods of ground motion is,greater the bridge collision response; traveling wave effect amplifies seismic pounding response, while the end of piers are adversely affected, exacerbating the damage. Although whether or not the traveling wave effect is harmful to the bearing, the traveling wave effect has obvious influences to bearing. Therefore, in the analysis of bridge seismic collision response it is necessary to consider traveling wave effect.

To evaluate the influences of the canyon topography on large structures, based on a rigid frame bridge across a 137-meter-deep and 600-meter-wide canyon, the seismic response of the canyon topography is analyzed under seismic SH waves with the assumptions of vertical incidence and oblique incidence to obtain the surface ground motions, which are used as the excitations for the bridge. It indicates that canyon topography has significant and complex influences on the surface ground motions. The peak ground accelerations vary greatly from the bottom of the canyon to the upper corners. And the ground surface has been characterized by larger relative displacements in the case of oblique incidence. Compared with the uniform seismic excitations, it’s hard to find out any regularity on structural seismic responses considering the canyon topography effects. The canyon topography can enlarge or minish the structural responses in terms of the different structure members, and it should be a carefully considered factor in structural seismic analysis and design.

In this paper, March 11, 2011 East-Japan Earthquake was introduced briefly, including main shock, aftershock and tsunami resulted from this earthquake. After that, the situation about bridge damage was focused; involving the bridge damage resulted from earthquake and tsunami, then some reason and preliminary findings were further suggested.

Damages of adjacent bridge girders due to pounding observed in Wenchuan earthquake are introduced in this paper. Based on Niulanjiang Bridge built in Yunnan province, nonlinear time history analyses are performed considering non-uniform seismic ground motion excitations, which are obtained by site seismic response analysis of the local canyon topography. And the effectiveness of cable restrainer device against unseating is studied through numerical simulations. The results show that pounding between adjacent segments of the bridge may obviously amplify the relative deformation of expansion joints, resulting in a higher probability of unseating. Cable restrainers can not only reduce the relative deformation of the expansion joints, but also mitigate the response of isolators. It also indicates that the cable restrainers can observably reduce the response of piers.

In this paper, a new fuzzy control arithmetic based on mode identification used in semi-active control is put forward, the mode is differentiated by the eigenvectors constituted with drift, velocity and their resultant, and then different fuzzy control strategy is applied. Moreover, by numerical simulation, the control efficiency of the new control arithmetic is compared with semi-active control using sign control law and some passive control.

In this paper, Shape Memory Alloy (SMA) Pseudo-Rubber Metal (PRM) was studied, and comparative test with common Pseudo-Rubber Metal was carried out. The enveloped area of hysteresis curve of SMA PRM is clearly larger than that of common PRM, which indicates the damping of SMA PRM overmatches that of common PRM. The stiffness value of SMA PRM and common PRM increases with their distortion amplitude’s increase, and the stiffness value of SMA PRM is less than that of common PRM. The carrying capacity, stiffness and damping of PRM are related with its relative density. The hysteresis behavior of SMA PRM is stable and basically not related with repeating load effect. Moreover, SMA PRM damper device was studied and developed, and comparative test with common Pseudo-Rubber Metal was carried out.

For small-scale RC structure model in earthquake simulation test, the material behavior of the model is hard to resemble the prototype well so that the model cannot simulate correctly the nonlinear performance of the prototype. On the basis of the dynamic similitude of mechanical behavior between common concrete and micro-concrete which derive from mechanical behavior tests, the simplified equivalent dynamic similitude relations, which are applicable to the nonlinear performance simulation with small-scale RC structure models in the earthquake simulation tests, have been proposed. By the numerical simulation of earthquake simulation tests and the deviation analysis, the dynamic simulation experimental method has been verified. In addition, for small-scaled RC model, to consider the similitude harmony between concrete and reinforcement used in the model, by adjusting the reinforcement and stirrup, or the effective section height (h0) and hoop spacing etc., simple element testing, shaking table test and numerical simulation were carried out to verify this model design method. Thus, it’s realizable that the small-scaled RC model can simulate correctly the nonlinear performance of the prototype.

Ovarian cancer is the leading cause of death among all gynecological cancers. This is mainly attributed to its frequent presentation at an advanced stage (International Federation of Gynecology and Obstetrics stage III-IV). Nuclear factor-kappaB (NF-κB) is critically involved in the carcinogenesis and development of ovarian cancer. A functional insertion/deletion polymorphism (-94 ins/del ATTG) in the promoter region of the NFKB1 gene, which encodes the p50 subunit of the NF-κB protein, has been recently identified and shown to increase the susceptibility to many diseases. The purpose of this study was to explore the association between this polymorphism and the risk of advanced ovarian cancer in a Chinese population. A total of 179 advanced ovarian cancer patients and 223 healthy controls were recruited into this study. Genotypes were determined using polymerase chain reaction-capillary electrophoresis method. The insertion increased the risk of advanced ovarian cancer (odds ratio = 2.111, 95% confidence intervals = 1.125-3.961, p = 0.019 for heterozygote insertion, and odds ratio = 2.656, 95% confidence intervals = 1.397-5.051, p = 0.002 for homozygote insertion) compared with homozygote deletion. Similar results were seen in age-adjusted analyses (p 0.05). Our preliminary results suggest that NFKB1-94 ins/del ATTG promoter polymorphism may be associated with increased susceptibility to advanced ovarian cancer.

In this paper, Shape Memory Alloy (SMA) Pseudo-Rubber Metal (PRM) was studied, and comparative test on mechanical behavior with common Pseudo-Rubber Metal was carried out, which indicates the damp of SMA PRM overmatches that of common PRM. Moreover, SMA PRM damper device was studied and developed, which can bear pull and press action, dissipate energy by two SMA PRM elements, furthermore, owing to the stiffness of SMA PRM increases with increase of distortion, this device can play role in restricting distortion. In order to study the control efficiency of SMA Pseudo-Rubber Metal damper on aseismic pounding of high-pier bridge, under El Centro, Taft and artificial ground motion respectively, to carry out seismic pounding shaking testing of high-pier bridge steel model and aseismic pounding shaking table testing of high-pier bridge steel model, furthermore, analyze detailedly the control efficiency of SMA Pseudo-Rubber Metal damper, which is adapted to reduce seismic pounding device and restrictor in high-pier and long span bridges.

Isolation technology is widely applied in civil engineering nowadays, while it is indicated by seismic damage investigations that the effect of vertical motion on buildings under earthquake couldn’t be ignored. In order to study the 3D isolation effect on high-rise buildings subjected to near-field ground motions, the finite element analysis of an 11-story reinforced concrete frame-shear wall building is conducted, three ground motions are selected, three kinds of structural model are calculated, which are without isolation, with horizontal isolation and with three-dimensional isolation. By analyzing and comparing the seismic response results of models, the 3D isolation effect is studied, and some conclusions are obtained.

To determine the serotype and genotype of a sample with ABO blood group discrepancies.Serotype was determined with serological method. Sequence specific primer polymerase chain reaction (SSP-PCR) was carried out based on the serotype. Sequences of exons 6 and 7 of ABO gene was analyzed by sequence-based testing (SBT).Completely agglutinated A antigen, half agglutinated B antigen and weak agglutinated anti-B antibody were detected in both erythrocytes and serum, which suggested presence of a ABw serotype. An A/Bw12 genotype was revealed by B subgroup detection. Sequences of exons 6 and 7 were 278CT, 297GA and 467CT, 526CG, 657CT, 703GA, 796CA, 803GC, 930GA, respectively. The genotype fit with A102/B101 except for a nt278 CT mutation. Blood group antigen gene mutation database (BGMUT) search has confirmed the mutant allele to be Bw12.An A102/Bw12 genotype has been found in the Chinese population.