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Your search keyword '"Qin Yu-juan"' showing total 14 results
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14 results on '"Qin Yu-juan"'

4. Loss of PDK4 expression promotes proliferation, tumorigenicity, motility and invasion of hepatocellular carcinoma cells

Author

Qin, Yu-Juan, primary, Lin, Tao-Yan, additional, Lin, Xiao-Lin, additional, Liu, Yu, additional, Zhao, Wen-Tao, additional, Li, Xiao-Yan, additional, Lian, Mei, additional, Chen, Heng-Wei, additional, Li, Yong-Long, additional, Zhang, Xiao-Ling, additional, Xiao, Dong, additional, Jia, Jun-Shuang, additional, and Sun, Yan, additional

Published
2020
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5. Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway

Author

Wang, Sheng-Chun, primary, Lin, Xiao-Lin, additional, Wang, Hui-Yan, additional, Qin, Yu-Juan, additional, Chen, Lin, additional, Li, Jing, additional, Jia, Jun-Shuang, additional, Shen, Hong-Fen, additional, Yang, Sheng, additional, Xie, Rao-Ying, additional, Wei, Fang, additional, Gao, Fei, additional, Rong, Xiao-Xiang, additional, Yang, Jie, additional, Zhao, Wen-Tao, additional, Zhang, Ting-Ting, additional, Shi, Jun-Wen, additional, Yao, Kai-Tai, additional, Luo, Wei-Ren, additional, Sun, Yan, additional, and Xiao, Dong, additional

Published
2015
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6. Cytokine-induced killer cells efficiently kill stem-like cancer cells of nasopharyngeal carcinoma via the NKG2D-ligands recognition

Author

Wei, Fang, primary, Rong, Xiao-Xiang, additional, Xie, Rao-Ying, additional, Jia, Li-Ting, additional, Wang, Hui-Yan, additional, Qin, Yu-Juan, additional, Chen, Lin, additional, Shen, Hong-Fen, additional, Lin, Xiao-Lin, additional, Yang, Jie, additional, Yang, Sheng, additional, Hao, Wei-Chao, additional, Chen, Yan, additional, Xiao, Sheng-Jun, additional, Zhou, Hui-Rong, additional, Lin, Tao-Yan, additional, Chen, Yu-Shuang, additional, Sun, Yan, additional, Yao, Kai-Tai, additional, and Xiao, Dong, additional

Published
2015
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7. Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition

Author

Rong, Xiao-Xiang, primary, Wei, Fang, additional, Lin, Xiao-Lin, additional, Qin, Yu-Juan, additional, Chen, Lin, additional, Wang, Hui-Yan, additional, Shen, Hong-Fen, additional, Jia, Li-Ting, additional, Xie, Rao-Ying, additional, Lin, Tao-Yan, additional, Hao, Wei-Chao, additional, Yang, Jie, additional, Yang, Sheng, additional, Cheng, Yu-Shuang, additional, Huang, Wen-Hua, additional, Li, Ai-min, additional, Sun, Yan, additional, Luo, Rong-Cheng, additional, and Xiao, Dong, additional

Published
2015
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8. MicroRNA-122 Triggers Mesenchymal-Epithelial Transition and Suppresses Hepatocellular Carcinoma Cell Motility and Invasion by Targeting RhoA

Author

Wang, Sheng-Chun, primary, Lin, Xiao-Lin, additional, Li, Jing, additional, Zhang, Ting-Ting, additional, Wang, Hui-Yan, additional, Shi, Jun-Wen, additional, Yang, Sheng, additional, Zhao, Wen-Tao, additional, Xie, Rao-Ying, additional, Wei, Fang, additional, Qin, Yu-Juan, additional, Chen, Lin, additional, Yang, Jie, additional, Yao, Kai-Tai, additional, and Xiao, Dong, additional

Published
2014
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13. Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition

Author

Rong, Xiao-Xiang, Wei, Fang, Lin, Xiao-Lin, Qin, Yu-Juan, Chen, Lin, Wang, Hui-Yan, Shen, Hong-Fen, Jia, Li-Ting, Xie, Rao-Ying, Lin, Tao-Yan, Hao, Wei-Chao, Yang, Jie, Yang, Sheng, Cheng, Yu-Shuang, Huang, Wen-Hua, Li, Ai-min, Sun, Yan, Luo, Rong-Cheng, and Xiao, Dong

Subjects
Cancer stem cells, cytokine-induced killer cells, hepatocellular carcinoma, in vivo bioluminescence imaging, NKG2D-ligands recognition, promoter-reporter gene strategy, time-lapse recording
Abstract

There is an urgent need for more potent and safer approaches to eradicate cancer stem cells (CSCs) for curing cancer. In this study, we investigate cancer-killing activity (CKA) of cytokine-induced killer (CIK) cells against CSCs of hepatocellular carcinoma (HCC). To visualize CSCs in vitro by fluorescence imaging, and image and quantify CSCs in tumor xenograft-bearing mice by bioluminescence imaging, HCC cells were engineered with CSC detector vector encoding GFP and luciferase controlled by Nanog promoter. We found that CIK cells have a strong CKA in vitro against putative CSCs of HCC, as shown by tumorsphere formation and time-lapse imaging. Additionally, time-lapse recording firstly revealed that putative CSCs were attacked simultaneously by many CIK cells and finally eradicated by CIK cells, indicating the necessity of achieving sufficient effector-to-target ratios. We firstly illustrated that anti-NKG2D antibody blocking partially but significantly inhibited CKA of CIK cells against putative CSCs. More importantly, intravenous infusion of CIK cells remarkably delayed tumor growth in mice with a significant decrease in putative CSC number monitored by bioluminescence imaging. Taken together, these findings demonstrate CKA of CIK cells against putative CSCs of HCC, at least in part, by NKG2D-ligands recognition.

Published
2016
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14. Hydrolysis of timosaponin BII by the crude enzyme from Aspergillus niger AS 3.0739.

Author

Zhou, Wen-Bin, Feng, Bing, Huang, Hong-Zhi, Liu, Ping, Yu, He-Shui, Zhao, Yang, Qin, Yu-Juan, Kang, Li-Ping, and Ma, Bai-Ping

Subjects
ASPERGILLUS, BIOTRANSFORMATION (Metabolism), DEMENTIA, GLYCOSIDES, HIGH performance liquid chromatography, MOLECULAR structure, NUCLEAR magnetic resonance spectroscopy, PHARMACEUTICAL chemistry, RESEARCH funding, METABOLISM, PHARMACOKINETICS, DRUG therapy
Abstract

Timosaponin BII (1), a steroidal saponin showing potential anti-dementia activity, was regioselectively hydrolyzed into its deglycosyl derivatives by the crude enzyme from Aspergillus niger AS 3.0739. Three biotransformation products, timosaponin BII-a (2), timosaponin BII-b (3), and timosaponin BII-c (4), were purified and their structures were elucidated on the basis of 1D NMR, 2D NMR, FAB-MS, and HR-ESI-MS spectral data. Compounds 2 and 3 are new compounds. [ABSTRACT FROM AUTHOR]

Published
2010
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