1,491 results on '"Qin Yin"'
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2. Palladium-catalyzed difluorocarbene transfer enables access to enantioenriched chiral spirooxindoles
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Zhiwen Nie, Keqin Wu, Xiaohang Zhan, Weiran Yang, Zhong Lian, Shaoquan Lin, Shou-Guo Wang, and Qin Yin
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Science - Abstract
Abstract We disclose herein an unprecedented Pd-catalyzed difluorocarbene transfer reaction, which assembles a series of structurally interesting chiral spiro ketones with generally over 90% ee. Commercially available BrCF2CO2K serves as the difluorocarbene precursor, which is harnessed as a user-friendly and safe carbonyl source in this transformation. Preliminary mechanistic studies exclude the formation of free CO in the reaction process, and importantly, we also find that BrCF2CO2K outcompete gaseous CO and several common CO surrogates in this asymmetric process. The reaction mechanism, including the in-situ progressive release of the difluorocarbene, the rapid migratory insertion of ArPd(II) = CF2 species, and subsequent defluorination hydrolysis by water to introduce the carbonyl group, accounts for the overall high efficiency and uniqueness. This work clearly showcases the advantage and potential of the difluorocarbene in synthesis and supplies a mechanistically distinct route for asymmetric carbonylative cyclization reactions.
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- 2024
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3. Influence of different composite curing agents on the rapid curing characteristics and mechanical performance of epoxy resins
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Ting Xu, Lizhou An, Qin Yin, Yumin Jiao, You Zhou, and Yefa Tan
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Physics ,QC1-999 - Abstract
To address the need for rapid in situ plugging and repair of hydraulic machinery and chemical pipelines and to resolve the issue that a single curing agent cannot simultaneously achieve rapid curing and excellent mechanical properties in epoxy resin systems, this study explores the use of composite curing agents. In particular, effective formulations are designed for mixing fast and slow curing agents, studying their effects on the curing behavior, curing quality, and mechanical properties of epoxy resins and elucidating their influence mechanisms. The results indicate that three resin systems meet the requirements for rapid curing (curing time within 30 min): 4A6B/EP, 2A8B/EP, and 0A10B/EP. Among them, 4A6B/EP exhibits the best curing quality and mechanical properties. In particular, 4A6B/EP demonstrates the lowest values of curing shrinkage rate, internal curing stress, average pore size, porosity, and cumulative pore volume. Its low internal stress and low defects reduce the stress concentration, while more efficient deflection and branching of internal cracks enhance its deformation resistance. Consequently, 4A6B/EP shows the highest microhardness, fracture toughness, tensile strength, Young’s modulus, and elongation after fracture. Based on the comprehensive evaluation of rapid curing characteristics and mechanical properties, the 4A6B/EP system offers the best overall performance. Therefore, it is recommended as the preferred resin system for rapid plugging and repair of composite materials, providing a theoretical basis and technical support for boosting the application of epoxy resin composite materials in high-tech fields.
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- 2024
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4. Induction of cytochrome P450 via upregulation of CAR and PXR: a potential mechanism for altered florfenicol metabolism by macranthoidin B in vivo
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Si-cong Li, Bin Wang, Min Zhang, Qin Yin, Zi-yi Yang, Xu-ting Li, and Ge Liang
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macranthoidin B ,cytochrome P450 ,constitutive androstane receptor ,pregnane X receptor ,florfenicol ,pharmacokinetics ,Therapeutics. Pharmacology ,RM1-950 - Abstract
IntroductionMacranthoidin B (MB) is a primary active component of Flos Lonicerae. In Chinese veterinary clinics, Flos Lonicerae is frequently used in combination with florfenicol to prevent and treat infections in livestock and poultry. However, potential interactions between Flos Lonicerae and florfenicol remain unclear. To systematically study these interactions, it is crucial to investigate the individual phytochemicals within Flos Lonicerae. Therefore, MB was selected for this study to assess its effect on the pharmacokinetics of florfenicol in vivo and to explore the underlying mechanisms involved.MethodsMale Sprague-Dawley rats were administered MB (60 mg/kg BW) or sterile water orally for 7 consecutive days. On the 8th day, a single oral dose of florfenicol (25 mg/kg BW) was given. Florfenicol pharmacokinetics were analyzed using ultra-high performance liquid chromatography. The hepatic expression levels of cytochrome P450 (CYP1A2, CYP2C11, CYP3A1), UDP-glucuronosyltransferase (UGT1A1), P-glycoprotein (P-gp), and nuclear receptors, including constitutive androstane receptor (CAR), pregnane X receptor (PXR), and retinoid X receptor alpha (RXRα), were quantified via reverse transcription-quantitative polymerase chain reaction and Western blotting (WB). Hepatic CYP1A2 and CYP2C11 activities were measured using a cocktail method. Additionally, the subcellular expression and localization of CAR, PXR, and RXRαin hepatocytes was assessed using WB and immunofluorescence staining.ResultsMB significantly reduces the AUC(0-∞) and MRT(0-∞) of florfenicol. MB also markedly upregulates the mRNA and protein expression of hepatic CYP1A2 and CYP2C11, along with their catalytic activities. Substantial upregulation of CAR and PXR proteins occurs in the hepatocyte nucleus, along with significant nuclear colocalization of the transcriptionally active CAR/RXRα and PXR/RXRαheterodimers, indicating MB-induced nuclear translocation of both CAR and PXR.DiscussionThese findings suggest that MB-induced alterations in florfenicol pharmacokinetics, particularly its accelerated elimination, may be due to increased expression and activities of CYP1A2 and CYP2C11, with CAR and PXR potentially involved in these regulatory effects. Further investigation is yet needed to fully elucidate the clinical implications of these interactions concerning the efficacy of florfenicol in veterinary medicine.
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- 2024
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5. Extraction optimization, antioxidants, and lipid-lowering activities of polygonatum cyrtonema Hua polysaccharides
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Jin Zuo, Wei Liu, Lei Tian, Mengyan Wang, Chunyan Liu, Min Wang, Zheng Fang, Jun Han, Guodong Wang, and Qin Yin
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Polygonatum cyrtonema Hua ,polysaccharide ,extraction optimization ,antioxidant activity ,lipid-lowering effect ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
ABSTRACTPolygonatum cyrtonema Hua polysaccharides (PCP) have beneficial effects on lipid metabolism and oxidative stress. Here, PCP extraction was optimized using response surface methodology (RSM), and the antioxidant and lipid-lowering effects of its main component, PCP1, were evaluated in vitro. The maximum PCP yield was 11.05% at an extraction temperature was 72°C, liquid-to-solid ratio of 21, extraction time of 96 min, and two extraction rounds. PCP1 was purified by column chromatography and showed significant scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl, and 2, 2'-azino-bis 3-ethylbenzthiazo-line-6-sulfonic acid (ABTS) radicals at concentration of 0.2–1.0 mg/mL. At a concentration of 200 [Formula: see text]g/mL, PCP1 significantly improved lipid disorder and damage induced by palmitic acid in HepG2 cells. These results show that PCP has potent antioxidant and lipid-lowering effects in vitro; moreover, the PCP extraction rate is significantly increased using RSM. Therefore, PCP is an effective antioxidant and lipid-lowering product with potential medicinal applications.
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- 2024
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6. The gingival crevicular fluid biomarkers with micropulse vibration device: A pilot study
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Liying Luo, Chengling Xu, Yao Li, Chunbo Hao, Jiao Zheng, Xiao Jin, Jiani Yu, Yuchang Zhu, Zhiqiang Guan, and Qin Yin
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Gingival crevicular fluid ,Orthodontic tooth movement ,Vibration ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Purpose: The aim of this study is to investigate the impact of vibration stimulation on gingival crevicular fluid biomarkers and orthodontic tooth movement. Methods: Forty patients were randomly assigned to receive therapy with an intraoral vibration device (n = 20, AcceleDent®) or no treatment (n = 20) at a university orthodontic clinic. The quantity of fluid in the gingival sulcus, biomarkers of each fluid in the gingival sulcus, and orthodontic tooth movement were analyzed at three-time intervals (T1, T2, T3) before and after therapy (T0). Results: The results showed that vibration treatment led to higher levels of osteoclast biomarkers (RNAKL, RANKL/OPG) and inflammatory biomarkers (TNF-, IL-11, IL-18) compared to the control group. Additionally, vibration treatment at T1, T2, and T3 significantly improved tooth mobility and GCF volume. The gingival crevicular fluid biomarker levels of the T0, T1, and T2 vibration groups, as well as IL-11, IL-18, TGF-1, and TNF-α vibration groups, were significantly higher than those of the control group at different time points. Conclusion: vibration therapy was found to be closely associated with bone-breaking cells and inflammatory factor levels.
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- 2024
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7. Heavy macrophage infiltration identified by optical coherence tomography relates to plaque rupture
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Xuan Shi, Tao Tao, Yi Wang, Yunfei Han, Xiaohui Xu, Qin Yin, Fang Wang, Rui Liu, and Xinfeng Liu
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Objective Risk stratification plays a critical role in patients with asymptomatic carotid atherosclerotic stenosis. Heavy macrophage infiltration (HMC) is an important factor of plaque destabilization. However, in vivo imaging technologies and screening criteria for HMC remain limited. We aimed to (i) introduce algorithms for in vivo detection of macrophage infiltrations using optical coherence tomography (OCT) and (ii) to investigate the threshold of HMC and its association with plaque vulnerability. Methods Ex vivo OCT images were co‐registered with histopathology in 282 cross‐sectional pairs from 19 carotid endarterectomy specimens. Of these, 197 randomly selected pairs were employed to define the parameters, and the remaining 85 pairs were used to evaluate the accuracy of the OCT‐based algorithm in detecting macrophage infiltrations. Clinical analysis included 93 patients receiving carotid OCT evaluation. The prevalence and burden of macrophage infiltration were analyzed. Multivariable and subgroup analysis were performed to investigate the association between HMC and plaque rupture. Results The sensitivity and specificity of algorithm for detecting macrophage infiltration were 88.0% and 74.9%, respectively. Of 93 clinical patients, ruptured plaques exhibited higher prevalence of macrophage infiltration than nonruptured plaques (83.7% [36/43] vs 32.0% [16/50], p
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- 2023
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8. Research on the Design of Operating Condition of Multi-Resistance Superconducting DC Current Limiter
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Qin YIN and Jinchuan GUO
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superconducting dc current limiter ,flexible dc transmission ,short-circuit current suppression ,scheme of electrical connection ,compact layout ,Energy industries. Energy policy. Fuel trade ,HD9502-9502.5 - Abstract
[Introduction] The working principle of the resistive superconducting current limiter is based on the zero resistance effect of the superconductor, which is connected in series in the line and basically has no resistance during normal operation. When the circuit is short-circuited and the current exceeds the critical current, the superconductor loses excess and the resistance value increases rapidly, which plays a role in limiting the short-circuit current. So the superconducting DC (Direct Current) current limiter has little effect on the power grid when it is in normal operation. When the system short-circuit current exceeds the critical current, it will quickly limit the current value, effectively reducing the requirements for DC equipment. Based on Nan'ao ±160 kV multi-terminal VSC-HVDC (Voltage Source Converter Based High Voltage Direct Current) system, the possible operating conditions of superconducting DC current limiter are discussed, and how to realize the possible operating conditions is analyzed. [Method] For the five possible operating conditions, it was recommended to set disconnector to achieve automatic switching of operating conditions. [Result] The proposed scheme of electrical connection and compact layout is given based on the configuration of the equipment. And according to different operating conditions, the corresponding current path diagram is given. [Conclusion] The possible working conditions of superconducting DC current limiter and the automatic switching electrical connection and compact layout can be obtained by similar analysis for other flexible DC transmission systems.
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- 2023
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9. Extraction, Identification, and Antioxidant Activity of Flavonoids from Hylotelephium spectabile (Boreau) H. Ohba
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Na Li, Xiao Wu, Qin Yin, Zeng Dong, Lele Zheng, Yihui Qian, Yulu Sun, Ziping Chen, and Kefeng Zhai
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Hylotelephium spectabile (Boreau) H. Ohba leaves total flavonoids ,response surface methodology ,macroporous adsorption resin separation and purification ,HPLC-MS ,antioxidant activity ,Chemical technology ,TP1-1185 - Abstract
The extraction of total flavonoids from Hylotelephium spectabile (Boreau) H. Ohba (H. spectabile) leaves was studied through the use of a double enzyme-assisted ultrasonic method, and the extraction process was optimized using the Box–Behnken design. Eight different macroporous resins were screened for purification in single-factorial experiments, and the flavonoid compounds in the extract of H. spectabile leaves were identified using HPLC-MS. Through the evaluation of the total reducing capacity and capacity for reducing 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH), hydroxyl radicals (·OH), and 2,2’-biazobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), the in vitro antioxidant activities of the crude extracts of the total flavonoids and purified total flavonoids of H. spectabile leaves were investigated. The results showed that the most efficient conditions for flavonoid extraction were an ultrasonic extraction time of 60 min, an ethanol concentration of 35%, a liquid-to-material ratio of 20:1 mL/g, and an amount of enzyme (cellulose/pectinase = 1:1) of 1.5%, forming H. spectabile powder. Under these conditions, the total flavonoid extraction rate in the H. spectabile leaf extract was 4.22%. AB-8 resin showed superior performance in terms of purification, and the optimal adsorption and desorption times were 1.5 h and 3 h, respectively. The recommended parameters for purification included a liquid volume of 5.5 BV, a flow rate of 1.2 BV/min, a pH of 5, and a concentration of 0.8 mg/mL. The observed order for reducing capacity was ascorbic acid (VC) > rutin > purified total flavonoids > crude extract of total flavonoids. The purified total flavonoid extract from H. spectabile showed a good scavenging ability against DPPH, ·OH, and ABTS·+, suggesting strong antioxidant activity. Therefore, this study can serve as technical support and reference data for the further development and utilization of H. spectabile resources.
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- 2024
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10. Extraction, Purification, Sulfated Modification, and Biological Activities of Dandelion Root Polysaccharides
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Xiao Wu, Na Li, Zeng Dong, Qin Yin, Tong Zhou, Lixiang Zhu, Hanxi Yan, Ziping Chen, and Kefeng Zhai
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dandelion root polysaccharide (DRP) ,sulfation ,structural characteristics ,biological activity ,Chemical technology ,TP1-1185 - Abstract
In this study, polysaccharides were extracted at a rate of 87.5% ± 1.5% from native dandelion roots, and the dandelion root polysaccharides (DRPs) were then chemically modified to obtain sulfated polysaccharides (SDRPs) with a degree of substitution of 1.49 ± 0.07. The effects of modification conditions, physicochemical characterizations, structural characteristics, antioxidant properties, hypoglycemic activity, and proliferative effects on probiotics of DRP derivatives were further investigated. Results showed that the optimum conditions for sulfation of DRPs included esterification reagents (concentrated sulfuric acid: n-butanol) ratio of 3:1, a reaction temperature of 0 °C, a reaction time of 1.5 h, and the involvement of 0.154 g of ammonium sulfate. The DRPs and SDRPs were composed of six monosaccharides, including mannose, glucosamine, rhamnose, glucose, galactose, and arabinose. Based on infrared spectra, the peaks of the characteristic absorption bands of S=O and C-O-S appeared at 1263 cm−1 and 836 cm−1. Compared with DRPs, SDRPs had a significantly lower relative molecular mass and a three-stranded helical structure. NMR analysis showed that sulfated modification mainly occurred on the hydroxyl group at C6. SDRPs underwent a chemical shift to higher field strength, with their characteristic signal peaking in the region of 1.00–1.62 ppm. Scanning electron microscopy (SEM) analysis indicated that the surface morphology of SDRPs was significantly changed. The structure of SDRPs was finer and more fragmented than DRPs. Compared with DRPs, SDRPs showed better free radical scavenging ability, higher Fe2+chelating ability, and stronger inhibition of α-glucosidase and α-amylase. In addition, SDRPs had an excellent promotional effect on the growth of Lactobacillus plantarum 10665 and Lactobacillus acidophilus. Therefore, this study could provide a theoretical basis for the development and utilization of DRPs.
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- 2024
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11. Evaluation of inpatient services of tertiary comprehensive hospitals based on DRG payment
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Qun-jun Yu, Ya-lin Li, Qin Yin, Ye Lu, Lu-yan Li, Dan-ni Xu, Mei He, Sha Ma, and Wu Yan
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DRG ,tertiary comprehensive hospital ,inpatient medical service ,evaluation ,rank sum ratio ,Public aspects of medicine ,RA1-1270 - Abstract
ObjectiveThis study aims to evaluate inpatient services in 49 tertiary comprehensive hospitals using indicators from the diagnosis related groups (DRG) payment system.MethodDRG data from 49 tertiary comprehensive hospitals were obtained from the quality monitoring platform for provincial hospitals, and relevant indicators were identified. The analytic hierarchy process (AHP) was used to compute the weight of each indicator. The rank sum ratio method was used to calculate the weight rank sum ratio (WRSR) value and the corresponding probit value of each hospital. The hospitals were divided into four grades based on the threshold value: excellent, good, fair, and poor.ResultsEight indicators of the 49 hospitals were scored, and the hospital rankings of indicators varied. The No. 1 hospital ranked first in the indicators of “total number of DRG”, “number of groups”, and “proportion of relative weights (RW) ≥ 2”. The WRSR value of the No.1 hospital was the largest (0.574), and the WRSR value of the No. 44 hospital was the smallest (0.139). The linear regression equation was established: WRSRpredicted =-0.141+0.088*Probit, and the regression model was well-fitted (F = 2066.672, p < 0.001). The cut-off values of the three WRSRspredicted by the four levels were 0.167, 0.299, and 0.431, respectively. The 49 hospitals were divided into four groups: excellent (4), good (21), average (21), and poor (3). There were significant differences in the average WRSR values of four categories of hospitals (p < 0.05).ConclusionThere were notable variances in the levels of inpatient services among 49 tertiary comprehensive hospitals, and hospitals of the same category also showed different service levels. The evaluation results contribute to the health administrative department and the hospital to optimize the allocation of resources, improve the DRG payment system, and enhance the quality and efficiency of inpatient services.
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- 2024
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12. Endovascular Recanalization for Nonacute Carotid Artery Occlusion: A Nationwide Registry‐Based Cohort Study
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Chao Hou, Xuan Shi, Shuxian Huo, Qin Yin, Xianjun Huang, Wen Sun, Guodong Xiao, Yong Yang, Hongbing Chen, Min Li, Mingyang Du, Yunfei Han, Xiaobing Fan, Qingshi Zhao, Shuanggen Zhu, Xinfeng Liu, and Ruidong Ye
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endovascular treatment ,internal carotid artery occlusion ,stroke ,Neurology. Diseases of the nervous system ,RC346-429 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background The management of nonacute symptomatic internal carotid artery occlusion remains unsatisfactory. Endovascular recanalization has been reported to be feasible but associated with a noteworthy risk of postprocedural complications in patients with symptomatic internal carotid artery occlusion. The present study aimed to investigate whether successful recanalization exerts clinical benefits over procedural risks. Methods We analyzed consecutive patients who underwent endovascular treatment of nonacute symptomatic internal carotid artery occlusion in a nationwide prospective registry. The primary outcome was the ipsilateral ischemic stroke recurrence. Other outcomes of interest included all strokes and death during follow‐up, and 30‐day symptomatic intracranial hemorrhage, and all strokes after intervention. Results The final analysis included 511 patients. Endovascular revascularization was successful in 300 patients (58.7%) but failed in 211 patients (41.3%). Patients with successful recanalization had less time from the last ischemic event to the endovascular treatment as compared with patients with failed recanalization (median [interquartile range] days, 18 [12–33] versus 22 [14–50]; P=0.003). Successful recanalization was associated with a higher rate of symptomatic intracranial hemorrhage within 30 days after intervention (odds ratio [OR], 7.99 [95% CI, 1.02–62.39]; P=0.047). Thirty‐day all strokes (OR, 1.91 [95% CI, 0.83–4.40]; P=0.128) and ischemic stroke (OR, 0.90 [95% CI, 0.33–2.46]; P=0.839) did not differ significantly. During a median follow‐up of 37 months, patients with successful recanalization demonstrated a reduced risk of ipsilateral ischemic stroke (adjusted hazard ratio, 0.28 [95% CI, 0.13–0.59]; P
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- 2024
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13. Neurophysiological mechanisms of cognition in the developing brain: Insights from intracranial EEG studies
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Qin Yin, Elizabeth L. Johnson, and Noa Ofen
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Developmental intracranial EEG (iEEG) ,Memory development ,Episodic memory ,Neural oscillations ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
The quest to understand how the development of the brain supports the development of complex cognitive functions is fueled by advances in cognitive neuroscience methods. Intracranial EEG (iEEG) recorded directly from the developing human brain provides unprecedented spatial and temporal resolution for mapping the neurophysiological mechanisms supporting cognitive development. In this paper, we focus on episodic memory, the ability to remember detailed information about past experiences, which improves from childhood into adulthood. We review memory effects based on broadband spectral power and emphasize the importance of isolating narrowband oscillations from broadband activity to determine mechanisms of neural coordination within and between brain regions. We then review evidence of developmental variability in neural oscillations and present emerging evidence linking the development of neural oscillations to the development of memory. We conclude by proposing that the development of oscillations increases the precision of neural coordination and may be an essential factor underlying memory development. More broadly, we demonstrate how recording neural activity directly from the developing brain holds immense potential to advance our understanding of cognitive development.
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- 2023
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14. A significant, functional and replicable risk KTN1 variant block for schizophrenia
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Qiao Mao, Xiandong Lin, Qin Yin, Ping Liu, Yong Zhang, Shihao Qu, Jianying Xu, Wenhong Cheng, Xinqun Luo, Longli Kang, Reyisha Taximaimaiti, Chengchou Zheng, Huihao Zhang, Xiaoping Wang, Honggang Ren, Yuping Cao, Jie Lin, and Xingguang Luo
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Medicine ,Science - Abstract
Abstract Cortical and subcortical structural alteration has been extensively reported in schizophrenia, including the unusual expansion of gray matter volumes (GMVs) of basal ganglia (BG), especially putamen. Previous genome-wide association studies pinpointed kinectin 1 gene (KTN1) as the most significant gene regulating the GMV of putamen. In this study, the role of KTN1 variants in risk and pathogenesis of schizophrenia was explored. A dense set of SNPs (n = 849) covering entire KTN1 was analyzed in three independent European- or African-American samples (n = 6704) and one mixed European and Asian Psychiatric Genomics Consortium sample (n = 56,418 cases vs. 78,818 controls), to identify replicable SNP-schizophrenia associations. The regulatory effects of schizophrenia-associated variants on the KTN1 mRNA expression in 16 cortical or subcortical regions in two European cohorts (n = 138 and 210, respectively), the total intracranial volume (ICV) in 46 European cohorts (n = 18,713), the GMVs of seven subcortical structures in 50 European cohorts (n = 38,258), and the surface areas (SA) and thickness (TH) of whole cortex and 34 cortical regions in 50 European cohorts (n = 33,992) and eight non-European cohorts (n = 2944) were carefully explored. We found that across entire KTN1, only 26 SNPs within the same block (r2 > 0.85) were associated with schizophrenia across ≥ 2 independent samples (7.5 × 10–5 ≤ p ≤ 0.048). The schizophrenia-risk alleles, which increased significantly risk for schizophrenia in Europeans (q 0.05), and (4) the TH of eight regional cortices potentially (0.006 ≤ p ≤ 0.050; q > 0.05), and consistently decreased (1) the BG GMVs significantly (1.8 × 10–19 ≤ p ≤ 0.050; q
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- 2023
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15. Enhancing the thermal and mechanical properties of carbon fiber/natural rubber composites by co-modification of dopamine and silane coupling agents
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Zhiyuan Chen, Qunzhang Tu, Xinmin Shen, Zhonghang Fang, Shaohua Bi, Qin Yin, and Xiangpo Zhang
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Carbon fiber ,Natural rubber ,Thermal conductivity ,Mechanical properties ,Surface modification ,Polydopamine ,Polymers and polymer manufacture ,TP1080-1185 - Abstract
In order to manufacture high-speed rubber tracks, it is urgent to develop natural rubber composites with excellent thermal and mechanical properties. In this paper, natural rubber was filled with milled carbon fiber (CF) which was synergistically modified by dopamine and silane coupling agent (SCA), including KH560, KH570 and KH590. Firstly, the polydopamine initial platform was formed on CF surface through self-polymerization of dopamine. Subsequently, SCA was grafted to improve the interface properties between the filler and the matrix. Eventually, the co-modified CF filled natural rubber (CF/NR) was fabricated by mechanical mixing method. The modification process was confirmed by scanning electron microscopy and other characterization methods. The heat build-up, thermal conductivity and mechanical properties of CF/NR were compared. The results showed that SCA could effectively graft on the polydopamine platform, and the thermal and mechanical properties of the three silane functionalized carbon fiber filled natural rubber composites were improved in different degrees. Among them, the carbon fiber grafted with KH590 filled natural rubber had the best comprehensive properties. Concretely, the thermal conductivity increased by 71.3% compared with the unfilled natural rubber, and the tensile strength increased by 73.3%. The improvement of the interfacial interaction of the modified fiber and rubber matrix was considered to be one of the essential reasons.
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- 2023
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16. Pollution characteristics and microbial community succession of a rural informal landfill in an arid climate
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Yu Liang, Qin Yin, Zijiang Jiang, Haihong Yan, and Yuegang Nian
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Informal landfill ,Pollution characteristics ,Microbial community succession ,Waste treatment ,Arid climate ,Environmental pollution ,TD172-193.5 ,Environmental sciences ,GE1-350 - Abstract
Informal landfills pose potential threats to the environment and human health due to the lack of anti-seepage measures. However, little research has been conducted on the distribution of pollutants in informal landfill sites situated in arid climates, as well as the underlying interaction mechanisms between environmental factors and microbial structure. In this study, we sought to investigate the pollution characteristics and microbial community succession of the landfill in northern China. The results revealed that heavy metals in the landfill showed poor mobility and migration. The lower layers of the garbage samples had higher water-soluble contents of heavy metals compared to the upper layers. The landfill-derived dissolved organic matter (DOM) was found to originate from microbial production, and four fluorescent components were identified, including fulvic acid-like substances, humus-like substances, and protein-like components. Fluorescence intensity and humification degree increased with increasing depth. The microbial diversity and richness decreased with sampling depth. The most abundant phyla in the samples were Proteobacteria, unidentified_Bacteria, Bacteroidota, Firmicutes, Myxococcota, Gemmatimonadota, Actinobacteria, and Deinococcota. As the sampling depth increased, Proteobacteria decreased, while Bacteroidota and Firmicutes showed a remarkable increase, with little variation observed in the other phyla. The partial least-squares path model (PLS-PM) results indicated that pH had the most significant effect on microbial abundance and diversity (direct effect value = −5.560), while DOM and heavy metals had the opposite effect, with direct effects of 1.838 and 3.231, respectively. DOM was identified as the driving factor for the variation in other environmental factors. The redundancy analysis (RDA) showed that the dominant genera were greatly influenced by Cu, humic-like substances, and protein-like substances. Among them, Bacillus, Alcanivorax, Devosia, and Chryseolinea may play important roles in the remediation of landfills. Our study not only gains a deeper understanding of the pollution risk of informal landfills in arid climates, but also provides a scientific basis for the future treatment and restoration of contaminated sites associated with landfills.
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- 2023
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17. A novel modified McLaughlin surgery for treating locked chronic posterior shoulder dislocation
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Fei Xiong, Qin Yin, Jian Wang, Changbao Wei, Sanjun Gu, and Yu Liu
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Chronic injury ,Posterior shoulder dislocation ,Reverse Hill-Sachs lesion ,Humeral head fracture ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Posterior shoulder dislocation is an uncommon orthopaedics injury and is frequently missed or misdiagnosed, accounting for 2%-4% of all shoulder dislocations, and is associated with the reverse Hill-Sachs lesion. Once posterior shoulder dislocation develops into a chronic disease, it will bring a lot of trouble to the treatment, especially in repairing the humeral defects. Surgical strategies are also developing and innovating to deal with this injury, including transfer of subscapularis tendon or lesser tubercle, humeral rotational osteotomy, autogenous bone graft or allograft. Shoulder replacement seems to be the ultimate and only option when the injury becomes irreparable, although some studies have shown unsatisfactory follow-up results. Considering no gold-standard treatment for locked posterior shoulder dislocation, we described a novel modified McLaughlin procedure for locked chronic posterior shoulder dislocation and evaluated the functional outcomes. Methods This study included five locked chronic posterior shoulder dislocation patients with an associated reverse Hill-Sachs lesion, in which the compression surface covered 30–40% of the humeral head. The mean period from injury to receiving surgery was 11.6 weeks (6–24 weeks). All five patients underwent the modified McLaughlin procedure, mainly divided into three steps, including open reduction, transfer of the partial lesser tuberosity and artificial bone to repair the reverse Hill-Sachs defects. The kernel technique was to fix the transferred tuberosity with two lag screws and strengthen it with two Ethibond sutures. The Constant-Murley score (CMS), the range of shoulder motion and the complications were recorded to assess and compare the functional situation of the shoulder postoperatively and postoperatively. Results After an average of 19.8 months (12–30) of follow-up, the mean CMS improved to 85.8 ± 4.9 (79–91) compared with 46.0 ± 4.5 (40–52) preoperatively, which showed a significant difference (p = 0.001). In the final follow-up, all five patients showed no symptoms of shoulder instability, and there was no pain or limited activity in daily life, thus all patients were satisfied with the results. Conclusion Repairing the reverse Hill-Sachs lesion by transferring the partial lesser tuberosity combined with artificial bone fixed by lag screws and sutures can ensure shoulder stability and provide pain relief and good function in patients with locked chronic posterior shoulder dislocation associated with the humeral head defect.
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- 2023
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18. Non-Covalent Functionalization of Graphene Oxide with POSS to Improve the Mechanical Properties of Epoxy Composites
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Ting Xu, Yumin Jiao, Zhenglian Su, Qin Yin, Lizhou An, and Yefa Tan
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polyhedral oligomeric silsesquioxane ,graphene oxide ,non-covalent functionalization ,epoxy resin ,mechanical properties ,Organic chemistry ,QD241-441 - Abstract
Phenyl polyhedral oligomeric silsesquioxane (POSS) is modified onto the GO surface by using the strong π–π coupling between a large number of benzene rings at the end of the phenyl POSS structure and the graphite structure in the GO sheet, realizing the non-covalent functionalization of GO (POSS-GO). The POSS-GO-reinforced EP (POSS-GO/EP) composite material is prepared using the casting molding process. The surface morphology of GO before and after modification and its peel dispersion in EP are examined. Furthermore, the mechanical properties, cross-sectional morphology, and reinforcement mechanism of POSS-GO/EP are thoroughly examined. The results show that the cage-like skeleton structure of POSS is embedded between the GO layers, increasing the spacing between the GO layers and leading to a steric hindrance effect, which effectively prevents their stacking and aggregation and improves the dispersion performance of GO. In particular, the 0.4 phr POSS-GO/EP sample shows the best mechanical properties. This is because, on the one hand, POSS-GO is uniformly dispersed in the EP matrix, which can more efficiently induce crack deflection and bifurcation and can also cause certain plastic deformations in the EP matrix. On the other hand, the POSS-GO/EP fracture cross-section with a stepped morphology of interlaced “canine teeth” shape is rougher and more uneven, leading to more complex crack propagation paths and greater energy consumption. Moreover, the mechanical meshing effect between the rough POSS-GO surface and the EP matrix is stronger, which is conducive to the transfer of interfacial stress and the strengthening and toughening effects of POSS-GO.
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- 2023
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19. Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis (CHESS1904): An international multicenter study
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Jun‐Hui Sun, He Zhao, Haijun Zhang, Lei Li, Necati Örmeci, Zi‐Niu Yu, Xun Li, Shuangxi Li, Xujun Yang, Huaping Wei, Xiaoliang Zhu, Zhengcong Zhang, Yajin Wang, Zhongwei Zhao, Jianting Mao, Qiaohong Wu, Xiaole Sun, Huiling Xiang, Kefeng Jia, Chao Yang, Wei Wu, Xiuqing Lin, Haixin Yao, Changzeng Zuo, Jitao Wang, Bo Zhang, Chunqing Zhang, Xiaoling Wu, Guangchuan Wang, Shengjuan Yao, Ruihang Wang, Li Zhou, Hui Huan, Qingli Tu, Xue Pu, Feng Zhang, Qin Yin, Linpeng Zhang, Ying Guo, Jian Wang, Kohei Kotani, Sawako Uchida‐Kobayashi, Norifumi Kawada, He Zhu, Li Li, Wei Wang, Guo Zhang, Lei Yu, Xudong Cui, Qingliang Zhu, Hailong Zhang, Xiaoli Hu, Rafael O. Ximenes, Adriano Gonçalves de Araújo, Giulliano Gardenghi, Yubao Zheng, Zebin Wu, Mingsheng Huang, Xiaoyong Chen, Jun Wu, Feng Xie, Yang Bo, Shengjuan Hu, Linke Ma, Xiao Li, and Xiaolong Qi
- Subjects
design ,hypertension ,multicenter study ,portal ,pressure ,prospective study ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Aim To determine the tolerance and acceptance of hepatic venous pressure gradient (HVPG) measurements in patients with liver cirrhosis. Methods This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG measurement between October 2019 and June 2020. Data related to the tolerance and acceptance of HVPG measurements were collected using descriptive questionnaires. Results HVPG measurements were technically successful in all 271 patients, with 141 (52.0%) undergoing HVPG measurement alone. The complication rate was 0.4%. Postoperative pain was significantly lower than preoperative expected pain (p
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- 2022
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20. Crosstalk between melatonin and reactive oxygen species in fruits and vegetables post-harvest preservation: An update
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Na Li, Kefeng Zhai, Qin Yin, Quan Gu, Xingtao Zhang, Merced G. Melencion, and Ziping Chen
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fruit ,melatonin ,post-harvest preservation ,reactive oxygen species ,signaling networks ,vegetable ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Fruits and vegetables contain numerous nutrients, such as vitamins, minerals, phenolic compounds, and dietary fibers. They reduce the incidence of cardiovascular diseases and the risk of certain chronic diseases, and improve the antioxidant and anti-inflammatory capacity. Moreover, melatonin was found in various fruits and vegetables species. Melatonin acts as a multifunctional compound to participate in various physiological processes. In recent years, many advances have been found that melatonin is also appraised as a key modulator on the fruits and vegetables post-harvest preservation. Fruits and vegetables post-harvest usually elicit reactive oxygen species (ROS) generation and accumulation. Excess ROS stimulate cell damage, protein structure destruction, and tissue aging, and thereby reducing their quality. Numerous studies find that exogenous application of melatonin modulates ROS homeostasis by regulating the antioxidant enzymes and non-enzymatic antioxidants systems. Further evidences reveal that melatonin often interacts with hormones and other signaling molecules, such as ROS, nitric oxide (NO), hydrogen sulfide (H2S), and etc. Among these ‘new’ molecules, crosstalks of melatonin and ROS, especially the H2O2 produced by RBOHs, are provided in fruits and vegetables post-harvest preservation in this review. It will provide reference for complicated integration of both melatonin and ROS as signal molecules in future study.
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- 2023
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21. Improving the energy release characteristics of PTFE/Al by doping magnesium hydride
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Jia-xiang Wu, Qiang Liu, Bin Feng, Qin Yin, Yu-chun Li, Shuang-zhang Wu, Zhong-shen Yu, Jun-yi Huang, and Xin-xin Ren
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PTFE/Al/MgH2 ,Mechanical properties ,Thermal behavior ,Reaction energy ,Ignition threshold ,Military Science - Abstract
Magnesium hydride (MgH2) was doped into PTFE/Al to improve the energy release characteristics of the material system and strive for better application in military engineering. Five types of PTFE/Al/MgH2 reactive materials with different MgH2 content were prepared by molding sintering method. The dynamic mechanical properties of the materials were studied by performing split-Hopkinson pressure bar (SHPB) tests and scanning electron microscope characterizations. The thermal behavior, reaction energy, reaction process and reaction mechanism were systematically investigated by conducting thermogravimetry-differential scanning calorimetry tests, oxygen bomb calorimeter measurements, X-ray diffraction and SHPB tests. The results show that MgH2 particles less than 10% content contribute to heightening the dynamic mechanical properties of PTFE/Al system. The product Mg generated by decomposition of MgH2 can not only react with gas phase C2F4+ but also undergo a Grignard-type reaction with condensed PTFE. The reaction energy and ignition threshold of PTFE/Al/MgH2 reactive materials enhance monotonously as MgH2 content rose. With the increase of MgH2 content from 0% to 20%, the reaction time is prolonged as well as the reaction intensity is enhanced dramatically arising from the massive water vapour produced by the reaction between O2 and H2. The gaseous products generated can form a high pressure shortly after the reaction, which helps to elevate the damage effect of the PTFE/Al system.
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- 2022
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22. Towards a Multilevel Framework of Teamwork Processes Affecting Construction Safety Outcomes
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Qin Yin, Esther Obonyo, and Somayeh Asadi
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construction management ,safety ,teamwork ,framework ,Building construction ,TH1-9745 - Abstract
The construction industry has one of the highest fatality and injury rates, highlighting the urgent need for research to reduce work-related injuries and fatalities. Given the complex nature of construction teams operating at different project levels, teamwork processes are crucial for ensuring construction safety. However, a comprehensive examination of teamwork processes concerning construction safety is lacking. Contemporary construction literature has a primary focus on a few key team-level factors. This study addresses this research gap by conducting a more holistic literature review, benchmarking knowledge from other industries, and proposing a framework specific to construction safety. The proposed framework integrates insights from team science and construction safety science, taking into consideration the industry’s complex team structure and dynamic nature. This study contributes to the improvement of safety outcomes in the construction industry by enhancing the understanding of teamwork processes’ impact on construction safety. The findings have practical implications for enhancing safety performance and reducing injuries and fatalities among construction workers.
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- 2023
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23. Thermal and combustion behavior of Al-MnO2 nanothermite with poly(vinylidene fluoride -co- hexafluoropropylene) energetic binder
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Jia-xing Song, Tao Guo, Miao Yao, Jia-lin Chen, Wen Ding, Feng-li Bei, Xiao-nan Zhang, Qin Yin, Jun-yi Huang, and Chang-hao Li
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Nanothermite ,Fluoropolymers ,Combustion ,Thermal analysis ,Military Science - Abstract
Fluoropolymers get increasing attention in energetic materials application due to the high fluorine content. To explore the effect of poly(vinylidene fluoride -co- hexafluoropropylene) (P(VDF-HFP)) on Al/MnO2 nanothermite, the samples with different contents are prepared and characterized by SEM, TG-DSC, XRD, and their ignition and combustion behavior are tested and recorded. The results show that P(VDF-HFP) as an energetic binder can combine the nanothermite components together, even exist in the gaps. The integrity of energetic materials has been improved. Thermal analysis shows that the addition of P(VDF-HFP) greatly changes the thermal reaction processes, and the exothermic peaks appear early, but the utilization of fuel and oxidizer is not efficient from the XRD results. Furthermore, the appropriate addition of P(VDF-HFP) can directly reduce the ignition energy threshold and increase the combustion time, which is necessary for the potential ignition charge application. The possible reasons for above phenomena are discussed and analyzed. This research provides a reference for improvement of thermite-based ignition charge formulation.
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- 2021
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24. Psychological responses among nurses caring for patients with COVID-19: a comparative study in China
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Honggang Ren, Xingguang Luo, Yincheng Wang, Xiaoyun Guo, Huiru Hou, Yong Zhang, Pengcheng Yang, Fang Zhu, Chao Hu, Runsheng Wang, Yu Sun, Yingzhen Du, Qin Yin, Guogang Xu, Hui Zuo, Qinyong Hu, and Yahui Wang
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Frontline healthcare nurses devoted themselves to deal with the outbreak of COVID-19, saving many lives. However, they are under incredible unknown psychological pressures with a considerable risk of infection. In this study, a self-administered questionnaire was used to survey 593 frontline nurses in Wuhan City and non-Hubei provinces for psychological responses from March 1 to March 10, 2020. Compared with nurses outside Hubei Province, those working in Wuhan were more likely to feel physically and mentally exhausted. Their probable depression and anxiety were significantly higher than those of nurses outside Hubei province (31.2%, 18.3% vs. 13.8%, 5.9%). Correspondingly, the depressive symptoms were more often reported in the Wuhan group (70.8% vs. 41.4%). Although Wuhan received wishes, concerns, and abundant psychological and material resources from all of the world, the survey-based study found that frontline nurses in Wuhan still had higher depression and anxiety with less social support compared with nurses from non-Hubei provinces. Unexpectedly, only 4.0% of nurses have sought psychological assistance. These findings suggested that the short-term psychological impact of frontline nurses in Wuhan during the COVID-19 outbreak was extremely high compared with nurses outside Hubei Province. This research enlightened the efficient integration of psychological resources, the optimization of the nurse emergency psychological assistance system, and the mental health care of medical staff during the outbreak of epidemics.
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- 2021
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25. Modeling and Verification of Rolling Resistance Torque of High-Speed Rubber Track Assembly Considering Hysteresis Loss
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Kang Liang, Qunzhang Tu, Xinmin Shen, Juying Dai, Qin Yin, Jinhong Xue, and Xuan Ding
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rubber track ,rolling resistance ,thermo-mechanical ,viscoelastic ,energy consumption ,Organic chemistry ,QD241-441 - Abstract
Due to the viscoelasticity of rubber materials, hysteresis loss due to deformation is the main reason for the rolling resistance of high-speed rubber tracks. Since the structure and material of high-speed rubber track assemblies are different from traditional tires and metal tracks, the rolling resistance theory of traditional wheeled and tracked vehicles is not applicable. Therefore, in order to determine the rolling resistance scientifically and accurately, the mechanism research of the rolling resistance of high-speed rubber track assembly is the key to the design of high-speed rubber crawler vehicles. In this paper, the stress–strain characteristics of rubber track under the action of compression, tension, bending, and driving were studied. The strain load spectrum of rubber tracks was established, and the strain cyclic load was extracted by the rainflow method. The temperature model of the rubber track was developed based on its dynamic characteristics. On the basis of energy conservation, the hysteresis loss of rubber is equivalent to the energy consumption of rolling resistance, and the theoretical model of rolling resistance of high-speed rubber track assembly is established. In accordance with the model above, the key influencing factors and changing trends of rolling resistance are analyzed, which provides a theoretical basis for the performance optimization of high-speed rubber track assembly.
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- 2023
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26. YY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box-mediated smooth muscle gene transcription during smooth muscle phenotypic modulation
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Jian-Pu Zheng, Xiangqin He, Fang Liu, Shuping Yin, Shichao Wu, Maozhou Yang, Jiawei Zhao, Xiaohua Dai, Hong Jiang, Luyi Yu, Qin Yin, Donghong Ju, Claire Li, Leonard Lipovich, Youming Xie, Kezhong Zhang, Hui J. Li, Jiliang Zhou, and Li Li
- Subjects
Medicine ,Science - Abstract
Abstract Yin Yang 1 (YY1) regulates gene transcription in a variety of biological processes. In this study, we aim to determine the role of YY1 in vascular smooth muscle cell (VSMC) phenotypic modulation both in vivo and in vitro. Here we show that vascular injury in rodent carotid arteries induces YY1 expression along with reduced expression of smooth muscle differentiation markers in the carotids. Consistent with this finding, YY1 expression is induced in differentiated VSMCs in response to serum stimulation. To determine the underlying molecular mechanisms, we found that YY1 suppresses the transcription of CArG box-dependent SMC-specific genes including SM22α, SMα-actin and SMMHC. Interestingly, YY1 suppresses the transcriptional activity of the SM22α promoter by hindering the binding of serum response factor (SRF) to the proximal CArG box. YY1 also suppresses the transcription and the transactivation of myocardin (MYOCD), a master regulator for SMC-specific gene transcription by binding to SRF to form the MYOCD/SRF/CArG box triad (known as the ternary complex). Mechanistically, YY1 directly interacts with MYOCD to competitively displace MYOCD from SRF. This is the first evidence showing that YY1 inhibits SMC differentiation by directly targeting MYOCD. These findings provide new mechanistic insights into the regulatory mechanisms that govern SMC phenotypic modulation in the pathogenesis of vascular diseases.
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- 2020
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27. Covered TIPS Procedure-Related Major Complications: Incidence, Management and Outcome From a Single Center
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Xiaochun Yin, Lihong Gu, Ming Zhang, Qin Yin, Jiangqiang Xiao, Yi Wang, Xiaoping Zou, Feng Zhang, and Yuzheng Zhuge
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transjugular intrahepatic portosystemic shunt ,portal hypertension ,major complications ,covered stents ,hemobilia ,Medicine (General) ,R5-920 - Abstract
Background and ObjectiveTransjugular intrahepatic portosystemic shunt (TIPS) is a well-established procedure for treating complications of portal hypertension. Due to the complexity of anatomy and difficulty of the puncture technique, the procedure itself might brought potential complications, such as puncture failure, bleeding, infection, and, rarely, death. The aim of this study is to explore the incidence, management, and outcome of TIPS procedure-related major complications using covered stents.MethodsPatients who underwent TIPS implantation from January 2015 to December 2020 were recruited retrospectively. Major complications after TIPS were screened and analyzed.ResultsNine hundred and forty-eight patients underwent the TIPS procedure with 95.1% (n = 902) technical success in our department. TIPS procedure-related major complications occurred in 30 (3.2%) patients, including hemobilia (n = 13; 1.37%), hemoperitoneum (n = 7; 0.74%), accelerated liver failure (n = 6; 0.63%), and rapidly progressive organ failure (n = 4; 0.42%). Among them, 8 patients died because of hemobilia (n = 1), accelerated liver failure (n = 4), and rapidly progressive organ failure (n = 3).ConclusionThe incidence of major complications related to TIPS procedure is relatively low, and some of them could recover through effective medical intervention. In our cohort, the overall incidence is about 3%, which causes 0.84% death. The most fatal complication is organ failure and hemobilia.
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- 2022
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28. Controllable synthesis of high-quality two-dimensional tellurium by a facile chemical vapor transport strategy
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Xinxin Zhao, Jianwei Shi, Qin Yin, Zhuo Dong, Yan Zhang, Lixing Kang, Qiang Yu, Cheng Chen, Jie Li, Xinfeng Liu, and Kai Zhang
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Materials science ,Materials synthesis ,Nanomaterials ,Science - Abstract
Summary: Recently, as an elementary material, tellurium (Te) has received widespread attention for its high carrier mobility, intriguing topological properties, and excellent environmental stability. However, it is difficult to obtain two-dimensional (2D) Te with high crystalline quality owing to its intrinsic helical chain structure. Herein, a facile strategy for controllable synthesis of high-quality 2D Te nanoflakes through chemical vapor transport in one step is reported. With carefully tuning the growth kinetics determined mainly by temperature, tellurium nanoflakes in lateral size of up to ∼40 μm with high crystallinity can be achieved. We also investigated the second harmonic generation of Te nanoflakes, which demonstrates that it can be used as frequency doubling crystals and has potential applications in nonlinear optical devices. In addition, field effect transistor devices based on the 2D Te nanoflakes were fabricated and exhibited excellent electrical properties with high mobility of 379 cm2 V−1 s−1.
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- 2022
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29. Experimental Investigation on Ignition Effects of Fuel Tank Impacted by Bi2O3-Reinforced PTFE/Al Reactive Material Projectile
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Ruiqi Wang, Qin Yin, Miao Yao, Junyi Huang, Rongxin Li, Zhenru Gao, Shuangzhang Wu, Yuchun Li, and Jiaxiang Wu
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PTFE/Al/Bi2O3 reactive material projectile ,ballistic impact experiments ,fuel tank ,impact behaviors ,ignition modes ,Mining engineering. Metallurgy ,TN1-997 - Abstract
A series of impact fuel tank experiments are carried out through the ballistic impact method. The ignition abilities of Bi2O3-reinforced PTFE/Al reactive material, metal aluminum, and inert metal steel are compared and analyzed, and the ignition mode of kerosene is explored when PTFE/Al/Bi2O3 impacts the fuel tank at different velocities. The results offer that PTFE/Al/Bi2O3 reactive material has outstanding ignition ability, and the order for ignition ability is PTFE/Al/Bi2O3 reactive material, metal aluminum, and inert metal steel. The kerosene content of the fuel tank has a significant impact on the ignition effect. The ignition effect of PTFE/Al/Bi2O3 reactive material impacting the fuel tank filled with 50% kerosene is weaker than that impacting the full tank. Under different impact velocities, PTFE/Al/Bi2O3 reactive materials display diverse ignition modes for kerosene: kerosene is directly ignited by the flame in the reverse reaction zone under low-velocity conditions, while high-temperature-activated reactive fragments are the ignition heat source of high-velocity conditions.
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- 2023
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30. Reliability of subsequent memory effects in children and adults: The good, the bad, and the hopeful
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Lingfei Tang, Qijing Yu, Roya Homayouni, Kelsey L. Canada, Qin Yin, Jessica S. Damoiseaux, and Noa Ofen
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FMRI ,Reliability ,Reproducibility ,Subsequent memory ,Development ,Test-retest ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Functional MRI (fMRI) is a key tool for investigating neural underpinnings of cognitive development. Yet, in recent years, the reliability of fMRI effects has come into question and with it, the feasibility of using task-based fMRI to identify developmental changes related to cognition. Here, we investigated the reliability of task-based fMRI activations with a widely used subsequent memory paradigm using two developmental samples: a cross-sectional sample (n = 85, age 8–25 years) and a test-retest sample (n = 24, one-month follow up, age 8–20 years). In the large cross-sectional sample, we found good to excellent group-level reliability when assessing activation patterns related to the encoding task and subsequent memory effects. In the test-retest sample, while group-level reliability was excellent, the consistency of activation patterns within individuals was low, particularly for subsequent memory effects. We observed consistent activation patterns in frontal, parietal, and occipital cortices, but comparatively lower test-retest reliability in subcortical regions and the hippocampus. Together, these findings highlight the limitations of interpreting task-based fMRI effects and the importance of incorporating reliability analyses in developmental studies. Leveraging larger and densely collected longitudinal data may help contribute to increased reproducibility and the accumulation of knowledge in developmental sciences.
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- 2021
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31. Task and Non-task Brain Activation Differences for Assessment of Depression and Anxiety by fNIRS
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Dan Wen, Xuenan Lang, Hang Zhang, Qiqi Li, Qin Yin, Yulu Chen, and Yong Xu
- Subjects
functional near-infrared spectroscopy ,non-task ,verbal fluency task ,anxiety ,depression ,Psychiatry ,RC435-571 - Abstract
Diagnosis and treatment of the patients with major depression (MD) or the combined anxiety and depression (A&D) depend on the questionnaire, sometimes accompanied by tasks such as verbal fluency task (VFT). Functional near infrared spectroscopy (fNIRS) is emerging as an auxiliary diagnostic tool to evaluate brain function, providing an objective criterion to judge psychoses. At present, the conclusions derived from VFT or rest (non-task) studies are controversial. The purpose of this study is to evaluate if task performs better than non-task in separating healthy people from psychiatric patients. In this study, healthy controls (HCs) as well as the patients with MD or A&D were recruited (n = 10 for each group) to participate in the non-task and VFT tasks, respectively, and the brain oxygenation was longitudinally evaluated by using fNIRS. An approach of spectral analysis is used to analyze cerebral hemoglobin parameters (i.e., Oxy and Deoxy), characterizing the physiological fluctuations in the non-task and task states with magnitude spectrum and average power. Moreover, the standard deviation of oxygenation responses during the non-task was compared with the peak amplitude during the task, with the aim to explore the sensitivity of the VFT task to brain activation. The results show that there is no significant difference (p > 0.05) among the three groups in average power during non-task. The VFT task greatly enhanced the magnitude spectrum, leading to significant difference (p < 0.05) in average power between any of two groups (HC, MD, and A&D). Moreover, 40% patients with A&D have an intermediate peak (around 0.05 Hz) in the magnitude spectrum when performing the VFT task, indicating its advantage in characterizing A&D. We defined a rate of the non-task standard variation to the task peak amplitude (namely, SD-to-peak rate) and found that this rate is larger than 20% in 90% of the MD subjects. By contrast, only 40% HC subjects have an SD-to-peak rate larger than 20%. These results indicate that the non-task may not be sufficient to separate MD or A&D from HC. The VFT task could enhance the characteristics of the magnitude spectrum, but its intensity needs to be elevated so as to properly explore brain functions related to psychoses.
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- 2021
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32. The Expression of IbMYB1 Is Essential to Maintain the Purple Color of Leaf and Storage Root in Sweet Potato [Ipomoea batatas (L.) Lam]
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Daowei Zhang, Yongjun Tan, Fang Dong, Ya Zhang, Yanlan Huang, Yizhou Zhou, ZhiJian Zhao, Qin Yin, Xuehua Xie, Xiewang Gao, Chaofan Zhang, and Naimei Tu
- Subjects
purple-fleshed sweetpotato ,anthocyanin biosynthesis ,R2R3-MYB ,transcriptome ,multiple members ,early response gene ,Plant culture ,SB1-1110 - Abstract
IbMYB1 was one of the major anthocyanin biosynthesis regulatory genes that has been identified and utilized in purple-fleshed sweet potato breeding. At least three members of this gene, namely, IbMYB1-1, -2a, and -2b, have been reported. We found that IbMYB1-2a and -2b are not necessary for anthocyanin accumulation in a variety of cultivated species (hexaploid) with purple shoots or purplish rings/spots of flesh. Transcriptomic and quantitative reverse transcription PCR (RT-qPCR) analyses revealed that persistent and vigorous expression of IbMYB1 is essential to maintain the purple color of leaves and storage roots in this type of cultivated species, which did not contain IbMYB1-2 gene members. Compared with IbbHLH2, IbMYB1 is an early response gene of anthocyanin biosynthesis in sweet potato. It cannot exclude the possibility that other MYBs participate in this gene regulation networks. Twenty-two MYB-like genes were identified from 156 MYBs to be highly positively or negatively correlated with the anthocyanin content in leaves or flesh. Even so, the IbMYB1 was most coordinately expressed with anthocyanin biosynthesis genes. Differences in flanking and coding sequences confirm that IbMYB2s, the highest similarity genes of IbMYB1, are not the members of IbMYB1. This phenomenon indicates that there may be more members of IbMYB1 in sweet potato, and the genetic complementation of these members is involved in the regulation of anthocyanin biosynthesis. The 3′ flanking sequence of IbMYB1-1 is homologous to the retrotransposon sequence of TNT1-94. Transposon movement is involved in the formation of multiple members of IbMYB1. This study provides critical insights into the expression patterns of IbMYB1, which are involved in the regulation of anthocyanin biosynthesis in the leaf and storage root. Notably, our study also emphasized the presence of a multiple member of IbMYB1 for genetic improvement.
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- 2021
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33. Effects of Air Plasma Modification on Aramid Fiber Surface and Its Composite Interface and Mechanical Properties
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Ting Xu, Zehao Qi, Qin Yin, Yumin Jiao, Lizhou An, and Yefa Tan
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atmospheric pressure air plasma ,treatment time ,discharge power ,aramid fiber ,epoxy resin ,interface and mechanical properties ,Organic chemistry ,QD241-441 - Abstract
In order to improve the interface and mechanical properties of aramid fiber (AF)-reinforced epoxy resin (EP) composites (AF/EPs), the surface modification of AF was carried out with atmospheric pressure air plasma, and the effects of plasma treatment time and discharge power on the AF surface and the interface and mechanical properties of AF/EPs were investigated. The results show that, when plasma treatment time was 10 min and discharge power was 400 W, AF showed the best modification effect. Compared to the unmodified material, the total content of active groups on the surface of AF increased by 82.4%; the contact angle between AF and EP decreased by 20%; the interfacial energy and work of adhesion increased by 77.1% and 19.1%, respectively; the loss of AF monofilament tensile strength was controlled at only 8.6%; and the interlaminar shear strength and tensile strength of AF/EPs increased by 45.5% and 10.4%, respectively. The improvement in AF/EP interfacial and mechanical properties is due to the introduction of more active groups on the AF surface with suitable plasma processing parameters, which strengthens the chemical bonding between the AF and EP matrix. At the same time, plasma treatment effectively increases the surface roughness of AF, and the mechanical meshing effect between the AF and EP matrix is improved. The synergistic effect of chemical bonding and mechanical meshing improves the wettability and interfacial bonding strength between the AF and EP matrix, which enables the load to be transferred from the resin to the fiber more efficiently, thereby improving the mechanical properties of the AF/EP.
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- 2022
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34. Molecular Dynamics Studies of the Mechanical Behaviors and Thermal Conductivity of Polyisoprene with Different Degrees of Polymerization
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Zhiyuan Chen, Qunzhang Tu, Zhonghang Fang, Xinmin Shen, Qin Yin, Xiangpo Zhang, and Ming Pan
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natural rubber ,polyisoprene ,molecular dynamics simulation ,polymerization ,uniaxial tension ,thermal conductivity ,Organic chemistry ,QD241-441 - Abstract
Polyisoprene, with a high degree of polymerization, is the main component of natural rubber. In the industrial production process, it is necessary to adjust the length of the macromolecule of polyisoprene to improve its plasticity. It is thus of vital importance to explore the effect of the degree of polymerization of polyisoprene on its properties, e.g., mechanical property and thermal property. Molecular dynamics simulations link microstructure to macroscopic properties. In this paper, Moltemplate was used to establish polyisoprene models with different degrees of polymerization, and the mechanical properties of polyisoprene under uniaxial tension were analyzed under an OPLS all-atom force field. The results showed that the strength and elastic modulus of the material increased with the increase in the degree of polymerization of the molecular chain. In the process of tensile loading, the non-bonded potential energy played a dominant role in the change of the total system potential energy. Then, the thermal conductivity of polyisoprene with different degrees of polymerization was calculated by the non-equilibrium molecular dynamics method (NEMD). The thermal conductivity of PI was predicted to converge to 0.179 W/(m·K). The mechanism of thermal conductivity of the polymer containing branched chains was also discussed and analyzed. The research content of this paper aims to provide theoretical support for improving the mechanical and thermal properties of natural rubber base materials.
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- 2022
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35. Optimal Design of Acoustic Metamaterial of Multiple Parallel Hexagonal Helmholtz Resonators by Combination of Finite Element Simulation and Cuckoo Search Algorithm
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Fei Yang, Enshuai Wang, Xinmin Shen, Xiaonan Zhang, Qin Yin, Xinqing Wang, Xiaocui Yang, Cheng Shen, and Wenqiang Peng
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broadband sound absorption ,optimal design ,acoustic metamaterial ,hexagonal Helmholtz resonators ,joint simulation method ,finite element simulation ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
To achieve the broadband sound absorption at low frequencies within a limited space, an optimal design of joint simulation method incorporating the finite element simulation and cuckoo search algorithm was proposed. An acoustic metamaterial of multiple parallel hexagonal Helmholtz resonators with sub-wavelength dimensions was designed and optimized in this research. First, the initial geometric parameters of the investigated acoustic metamaterials were confirmed according to the actual noise reduction requirements to reduce the optimization burden and improve the optimization efficiency. Then, the acoustic metamaterial with the various depths of the necks was optimized by the joint simulation method, which combined the finite element simulation and the cuckoo search algorithm. The experimental sample was prepared using the 3D printer according to the obtained optimal parameters. The simulation results and experimental results exhibited excellent consistency. Compared with the derived sound absorption coefficients by theoretical modeling, those achieved in the finite element simulation were closer to the experimental results, which also verified the accuracy of this optimal design method. The results proved that the optimal design method was applicable to the achievement of broadband sound absorption with different low frequency ranges, which provided a novel method for the development and application of acoustic metamaterials.
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- 2022
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36. Polydopamine and Mercapto Functionalized 3D Carbon Nano-Material Hybrids Synergistically Modifying Aramid Fibers for Adhesion Improvement
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Zhonghang Fang, Qunzhang Tu, Xuan Yang, Xinmin Shen, Qin Yin, and Zhiyuan Chen
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aramid fiber ,polydopamine ,graphene oxide ,carbon nanotube ,interfacial adhesion ,Organic chemistry ,QD241-441 - Abstract
In order to solve the problem of poor interfacial adhesion between aramid fibers and a rubber matrix, an efficient and mild modification method was proposed via polydopamine and mercapto functionalized graphene oxide (GO) and carbon nanotube (CNTs) hybrids synergistically modifying aramid fibers. GO and CNTs were firstly stacked and assembled into unique 3D GO-CNTs hybrids through π-π conjugation. Then, the mercapto functionalization of the assembled 3D GO-CNTs hybrids was realized via the dehydration condensation reaction between the hydroxyls of GO and the silanol groups of coupling agent. Finally, the mercapto functionalized 3D GO-CNTs hybrids were grafted onto the aramid fibers, which were pre-modified by polydopamine through the Michael addition reaction mechanism. The surface morphology and chemical structures of GO-CNTs hybrids and fibers and the interfacial adhesion strength between fibers and rubber matrix were investigated. The results showed that the modification method had brought about great changes in the surface structure of fibers but not generated any damage traces. More importantly, this modification method could improve the interfacial strength by 110.95%, and the reason was not only the reactivity of functional groups but also that the 3D GO-CNTs hybrids with excellent mechanical properties could effectively share interfacial stress. The method proposed in this paper was universal and had the potential to be applied to other high-performance fiber-reinforced composites.
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- 2022
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37. Psychological Responses of the Patients in Cabin Hospital to the COVID-19 Outbreak: A Comparative Epidemiologic Analysis
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Yahui Wang, Mengyue Zhang, Qin Yin, Yincheng Wang, Pengcheng Yang, Chao Hu, Guogang Xu, Daoweng Wang, Xianzhi Li, Jibo He, Qinyong Hu, Xingguang Luo, and Honggang Ren
- Subjects
COVID-19 ,cabin hospital ,psychological responses ,psychological assistance ,depression ,anxiety ,Psychology ,BF1-990 - Abstract
The building of cabin hospitals in Wuhan has been proven to be clinically successful in curing mild-symptom COVID-19 patients shortly after the outbreak of COVID-19 in late 2019. At the same time, the psychological effect of patients being treated in cabin hospitals and the features of the psychological status of the whole society remained ambiguous. This study adopted a self-administrated questionnaire to investigate the stress, depression, and anxiety status of patients in cabin hospitals (n = 212) and healthy participants outside of Hubei province (n = 221) in a population level from February 29 to March 01, 2020. The research measured participants’ stress response, depression level, and anxiety level as well as their social support system and their resilience level. Results indicated that in this sudden outbreak of an unknown pandemic, all people (whether or not infected) showed a generally high level of stress, depression, and anxiety, regardless of age, gender, education level, and employment. It also showed that people with a lower level of psychological resilience and social support reported more severe symptoms of depression, anxiety, and stress. Moreover, the research also found a positive effect of cabin hospitals on the psychological recovery of COVID-19 patients. Stress response of patients increased after entering into cabin hospitals, while after 3–4 weeks’ treatment, patients showed a decrease in their depression and anxiety levels. This research advances the understanding of COVID-19 and gives suggestions to optimize the design and the allocation of resources in cabin hospitals and better deal with the unknown pandemics in the future.
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- 2021
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38. fNIRS Evaluation of Frontal and Temporal Cortex Activation by Verbal Fluency Task and High-Level Cognition Task for Detecting Anxiety and Depression
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Xuenan Lang, Dan Wen, Qiqi Li, Qin Yin, Mingyu Wang, and Yong Xu
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functional near-infrared spectroscopy ,high-level cognition task ,verbal fluency task ,anxiety ,depression ,Psychiatry ,RC435-571 - Abstract
Anxiety and depression are widespread psychosis which are believed to affect cerebral metabolism, especially in frontal and temporal cortex. The comorbidity patients of anxiety and depression (A&D) have more serious clinical symptoms. Functional near-infrared spectroscopy (fNIRS) is a noninvasive modality used to monitor human brain oxygenation, and it could be considered as a potential tool to detect psychosis which may lead to abnormal cerebral oxygen status when the brain is activated. However, how sensitive the cerebral oxygenation response to the cortex activation and whether these responses are consistent at different stages of A&D or different regions still remains unclear. In this study, a conventional physiological paradigm for cortex activation, i.e., verbal fluency task (VFT), and a relatively new paradigm, i.e., high-level cognition task (HCT), were compared to detect A&D through a longitudinal measurement of cerebral oxygen status by fNIRS. The A&D patients at the acute, consolidation and maintenance stages as well as the healthy subjects participated in the VFT and HCT paradigms, respectively. For the VTF paradigm, the subject was instructed to answer questions of phrase constructions within 60 s. For the HCT paradigm, the subject was instructed to categorize items, logical reasoning, and comprehensive judgment and write down the answers within 60 s. For most of the subjects, the oxy-Hb is found to increase remarkably, accompanied with a relatively small reduction in deoxy-Hb when subject to both paradigms. The statistical analyses show a relatively large variability within any group, leading to the significant difference that was only found between A&D at the acute stage and healthy subjects in the temporal lobe region (p < 0.001). Nevertheless, HCT would activate more oxygen increment when compared with the VFT, with a large integral value in oxy-Hb. On average, the oxy-Hb integral value of the A&D patients differs substantially at different stages when subject to HCT paradigm. Moreover, the prefrontal lobe and temporal lobe responses were more consistent to the HCT paradigm rather than the VFT paradigm. Under the VFT paradigm, however, no remarkable difference in integral value was found among the three stages, either at the prefrontal lobe or at the temporal lobe. This study indicated that HCT, which is intensively involved in brain function, would activate more oxygenation changes in the cerebral cortex. Additionally, with good performance at distinguishing different stages according to the oxy-Hb criterion, the HCT has the potential to evaluate the therapeutic effects for A&D patients.
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- 2021
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39. Function Prediction for G Protein-Coupled Receptors through Text Mining and Induction Matrix Completion
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Jiansheng Wu, Qin Yin, Chengxin Zhang, Jingjing Geng, Hongjie Wu, Haifeng Hu, Xiaoyan Ke, and Yang Zhang
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Chemistry ,QD1-999 - Published
- 2019
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40. Study on Increasing the Binding Amount of Rubber and Reinforcing Filler by Adding Aromatic Solvent Oil
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Xiaoqing Li, Zhonghang Fang, Xinmin Shen, Qin Yin, Zhiyuan Chen, Qunzhang Tu, and Ming Pan
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rubber ,aromatic solvent oil ,reinforcing filler ,binding amount ,curing characteristics ,physical performance ,Organic chemistry ,QD241-441 - Abstract
The binding amount of rubber and reinforcing filler directly affects the quality of rubber products. The effect of aromatic solvent oil (S-150) on the binding amount of rubber and reinforcing filler was studied. In order to determine the suitability of rubber after adding S-150, the curing characteristics, physical performance and tensile properties of rubber samples were tested and analyzed. Meanwhile, the microstructure of the composite was analyzed by scanning electron microscopy (SEM). The test results showed that the binding amount of rubber and reinforcing filler was increased after adding S-150. The density and Shore A hardness were decreased. When carbon black was 80 phr, after adding 40 phr of S-150, the rebound resilience of rubber increased by 13% on average, and the elongation at break increased by 88% on average. When white carbon black was between 10-70 phr, after adding 65 phr of S-150, the rebound resilience of rubber increased by 9% on average, and the elongation at break increased by 51% on average. Modulus at 100% and tensile strength were decreased. Meanwhile, it could be judged from the microstructure results that the reticulation space inside the rubber was increased, the agglomerate particles were relatively uniform, and no bubbles or holes were observed. The mechanism that S-150 could increase the binding amount of rubber was analyzed according to the like-dissolves-like principle. This research achievement could lead to improvements in the quality of rubber products and promote their practical application.
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- 2022
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41. Development and Optimization of Broadband Acoustic Metamaterial Absorber Based on Parallel–Connection Square Helmholtz Resonators
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Enshuai Wang, Fei Yang, Xinmin Shen, Haiqin Duan, Xiaonan Zhang, Qin Yin, Wenqiang Peng, Xiaocui Yang, and Liu Yang
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acoustic metamaterial absorber ,parallel–connection square Helmholtz resonators ,low frequency noise control ,particle swarm optimization algorithm ,finite element simulation model ,adjustable frequency spectrum ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
An acoustic metamaterial absorber of parallel–connection square Helmholtz resonators is proposed in this study, and its sound absorption coefficients are optimized to reduce the noise for the given conditions in the factory. A two–dimensional equivalent simulation model is built to obtain the initial value of parameters and a three–dimensional finite element model is constructed to simulate the sound absorption performance of the metamaterial cell, which aims to improve the research efficiency. The optimal parameters of metamaterial cells are obtained through the particle swarm optimization algorithm, and its effectiveness and accuracy are validated through preparing the experimental sample using 3D printing and measuring the sound absorption coefficient by the standing wave tube detection. The consistency between the experimental data and simulation data verifies feasibility of the proposed optimization method and usefulness of the developed acoustic metamaterial absorber, and the desired sound absorption performances for given conditions are achieved. The experimental results prove that parallel–connection square Helmholtz resonators can achieve an adjustable frequency spectrum for the low frequency noise control by parameter optimization, which is propitious to promote its application in reducing the noise in the factory.
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- 2022
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42. Acoustic Metamaterials for Low-Frequency Noise Reduction Based on Parallel Connection of Multiple Spiral Chambers
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Haiqin Duan, Fei Yang, Xinmin Shen, Qin Yin, Enshuai Wang, Xiaonan Zhang, Xiaocui Yang, Cheng Shen, and Wenqiang Peng
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acoustic metamaterial ,noise control ,multiple spiral chambers ,Fabry–Perot resonance ,low-frequency sound absorption ,finite element simulation ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Acoustic metamaterials based on Helmholtz resonance have perfect sound absorption characteristics with the subwavelength size, but the absorption bandwidth is narrow, which limits the practical applications for noise control with broadband. On the basis of the Fabry–Perot resonance principle, a novel sound absorber of the acoustic metamaterial by parallel connection of the multiple spiral chambers (abbreviated as MSC-AM) is proposed and investigated in this research. Through the theoretical modeling, finite element simulation, sample preparation and experimental validation, the effectiveness and practicability of the MSC-AM are verified. Actual sound absorption coefficients of the MSC-AM in the frequency range of 360–680 Hz (with the bandwidth Δf1 = 320 Hz) are larger than 0.8, which exhibit the extraordinarily low-frequency sound absorption performance. Moreover, actual sound absorption coefficients are above 0.5 in the 350–1600 Hz range (with a bandwidth Δf2 = 1250 Hz), which achieve broadband sound absorption in the low–middle frequency range. According to various actual demands, the structural parameters can be adjusted flexibly to realize the customization of sound absorption bandwidth, which provides a novel way to design and improve acoustic metamaterials to reduce the noise with various frequency bands and has promising prospects of application in low-frequency sound absorption.
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- 2022
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43. Current Status of Sarcopenia in the Disabled Elderly of Chinese Communities in Shanghai: Based on the Updated EWGSOP Consensus for Sarcopenia
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Qing Fang, Guoying Zhu, Jianwei Huang, Shayi Pan, Minyan Fang, Qiuting Li, Qin Yin, Xiaoqing Liu, Qingya Tang, Dongping Huang, and Jingmin Liu
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sarcopenia ,disability ,elderly ,handgrip strength ,China ,Medicine (General) ,R5-920 - Abstract
Our study aimed to investigate the prevalence and associated factors of sarcopenia in the disabled elderly in communities in Shanghai, China. A cross-sectional study was conducted in 2018. Five hundred and seventy two participants (≥60 years) were recruited through cluster sampling from Putuo District of Shanghai. Sarcopenia was defined according to the updated consensus of the European Sarcoma Working Group in 2019. The sarcopenia, depression, and nutrition status were assessed by using SARC-F, the Short Version of the Center for Epidemiological Studies Depression Scale (CES-D-10), and the Mini Nutritional Assessment-Short form (MNA-SF), respectively Physical activity was also assessed. Our results showed the prevalence of sarcopenia was 0.5%, but the prevalence of low handgrip strength was 37.2% (male, 5.5%; female, 39.1%). The modified Poisson regression model was used to evaluate the relationship among related variables and low handgrip strength. The risk for low handgrip strength was higher in the physically disabled subjects than in the visually disabled ones (aPR: 1.69, 95% CI: 1.88-2.42). Depressive symptoms (aPR: 1.31, 95% CI: 1.04-1.62) and PASE score (aPR: 0.99, 95% CI: 0.99-1.00) were independently associated with low handgrip strength. In summary, the prevalence of EWGSOP2-defined sarcopenia is low and the prevalence of declined muscle strength is high in the disabled elderly. The elderly participants with a physical disability had a higher prevalence of low hand handgrip strength than those with a visual disability. More studies with a larger sample size and longitudinal follow-up are needed to confirm our findings.
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- 2020
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44. Safety and long-term outcomes of early gastric cardiac cancer treated with endoscopic submucosal dissection in 499 Chinese patients
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Shouli Cao, Tianhui Zou, Qi Sun, Tianyun Liu, Ting Fan, Qin Yin, Xiangshan Fan, Jingwei Jiang, Dekusaah Raymond, Yi Wang, Bin Zhang, Ying Lv, Xiaoqi Zhang, Tingsheng Ling, Yuzheng Zhuge, Lei Wang, Xiaoping Zou, Guifang Xu, and Qin Huang
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Aims: Early gastric cardiac cancer (EGCC) has a low risk of lymph node metastasis with the potential for endoscopic therapy. We aimed to evaluate the short- and long-term outcomes of endoscopic submucosal dissection (ESD)-resected EGCCs in a large cohort of Chinese patients and compare endoscopic and clinicopathologic features between EGCC and early gastric non-cardiac cancer (EGNC). Methods: We retrospectively studied 512 EGCCs in 499 consecutive patients and 621 EGNCs in 555 consecutive patients between January 2011 and March 2018 at our center. We investigated clinicopathological characteristics of EGCC tumors, ESD treatment results, adverse events, and postresection patient survival. Results: Compared with EGNC patients, EGCC patients were significantly older (average age: 66 years versus 62 years, p
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- 2020
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45. Superficial Calcification With Rotund Shape Is Associated With Carotid Plaque Rupture: An Optical Coherence Tomography Study
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Xuan Shi, Yunfei Han, Min Li, Qin Yin, Rui Liu, Fang Wang, Xiaohui Xu, Yunyun Xiong, Ruidong Ye, and Xinfeng Liu
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calcification ,atherosclerosis ,carotid stenosis ,optical coherence tomography (OCT) ,plaque rupture ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: Plaque rupture is an important etiology for symptomatic carotid stenosis. The role of calcification in the plaque vulnerability has been controversial. We aimed to detect the geometric features of calcifications in carotid plaque and to examine its association with plaque rupture.Methods: Optical coherence tomography assessment of carotid plaque was performed in 88 patients. Calcification shape was evaluated through quantitative measurements of the long and short axis, area size, circumference, calcification arc, and longitudinal length. Calcification location was analyzed through the distance to the lumen. Furthermore, we developed idealized fluid-structure interaction models to investigate the association of calcification shape and plaque stress.Results: A total of 33 ruptured plaques and 30 non-ruptured plaques were recognized. Ruptured plaques had more multiple calcifications and protruded calcifications. The calcifications in the ruptured plaques displayed a remarkably lower long-axis/short-axis (L/S) ratio than in the non-ruptured plaques (p = 0.001). We classified calcification shape into crescentic calcification (L/S > 2.5) and rotund calcification (L/S ≤ 2.5). Rotund-shaped calcifications were more common in ruptured plaques than in non-ruptured plaques (p = 0.02). Superficial calcifications with minimal distance to the lumen ≤ 50 μm accounted for 79.4% of all calcifications in the ruptured plaques, and only 7.7% in the non-ruptured plaques (p < 0.001). Biomechanical analysis showed that the plaque with rotund-shaped calcification developed 7.91-fold higher von Mises stress than the plaque with crescentic calcification.Conclusions: Superficial calcifications and rotund-shaped calcifications are associated with carotid plaque rupture, suggesting that calcification location and shape may play a key role in plaque vulnerability.
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- 2020
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46. A Likely Role for a Novel Cell Therapeutic Target of Transforming Growth Factor-β1 on Radiation Pneumonitis in Lung and Nasopharyngeal Cancer Patients
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Qin Yin, Bing Zhu, Jixian Zhang, Yihan Yu, and Pengcheng Li
- Subjects
Medicine - Abstract
The association between the polymorphism of transforming growth factor (TGF)-β1 and risk of radiation pneumonitis has been extensively investigated; however, conclusive results were unavailable. Eligible studies were identified from the database of Medline, Web of Science, EMBASE, and CNKI (China Knowledge Resource Integrated Database) up to September 2019. The odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the strength of the relationship. The results showed that there were associations between TGF 869 T/C (rs1982073) and risks of radiation pneumonitis. Subgroup analyses showed that TGF 869 T/C was associated with risk of radiation pneumonitis in Caucasians (OR [95% CI]: 0.45 [0.31 to 0.67] for C carriers vs. TT). In addition, subgroup analyses also suggested that the C allele was associated with decreased risks of radiation pneumonitis among hospital-based case–control studies (0.56 [0.39 to 0.82] for C carriers vs. TT). Meanwhile, C allele was also suggested to be associated with decreased risk of radiation pneumonitis among PCC (0.60 [0.38 to 0.96] for C carriers vs. TT). Especially, C allele was also found to be associated with decreased risk of radiation pneumonitis from the participants with lung cancer (0.57 [0.37 to 0.90] for C carriers vs. TT). Our meta-analysis shows that T allele in TGF 869 T/C is significantly associated with the increased risk of radiation pneumonitis, especially for Caucasians, and for the participants with lung cancer.
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- 2020
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47. Crocin Alleviates Pain Hyperalgesia in AIA Rats by Inhibiting the Spinal Wnt5a/β-Catenin Signaling Pathway and Glial Activation
- Author
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Jin-Feng Wang, Hai-Jun Xu, Zhao-Long He, Qin Yin, and Wei Cheng
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
At present, most of the drugs have little effect on the pathological process of rheumatoid arthritis (RA). Analgesia is an important measure in the treatment of RA and is also one of the criteria to determine the therapeutic effects of the disease. Some studies have found that crocin, a kind of Chinese medicine, can effectively alleviate pain sensitization in pain model rats, but the mechanism is not clear. Emerging evidence indicates that crocin may inhibit the metastasis of lung and liver cancer cells from the breast by inhibiting Wnt/β-catenin and the Wnt signaling pathway is closely related to RA. Wnt5a belongs to the Wnt protein family and was previously thought to be involved only in nonclassical Wnt signaling pathways. Recent studies have shown that Wnt5a has both stimulatory and inhibitory effects on the classical Wnt signaling pathway, and so, Wnt5a has attracted increasing attention. This study demonstrated that crocin significantly increased the mechanical thresholds of adjuvant-induced arthritis (AIA) rats, suggesting that crocin can alleviate neuropathic pain. Crocin significantly decreased the levels of pain-related factors and glial activation. Foxy5, activator of Wnt5a, inhibited the above effects of crocin in AIA rats. In addition, intrathecal injection of a Wnt5a inhibitor significantly decreased hyperalgesia in AIA rats. This research shows that crocin may alleviate neuropathic pain in AIA rats by inhibiting the expression of pain-related molecules through the Wnt5a/β-catenin pathway, elucidating the mechanism by which crocin relieves neuropathic pain and provides a new way of thinking for the treatment of AIA pain.
- Published
- 2020
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48. Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate
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Jian Zuo, Qin Yin, Lin Wang, Wen Zhang, Yan Fan, Yu-Yan Zhou, Yan Li, and Guo-Dong Wang
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rheumatoid arthritis ,α- mangostin ,t cells ,disease modifying antirheumatic drug ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Context: Garcinia mangostana Linn. (Guttiferae) pericarp is used as a traditional medicine in South Asia to treat inflammatory diseases. Objective: This study investigates therapeutic effects of G. mangostana pericarp ethanol extract (MAN) on collagen-induced arthritis (CIA) and interactions with methotrexate in vivo. Materials and methods: Male Sprague-Dawley rats with CIA were treated with MAN (0.5 g/kg/day), methotrexate (0.5 mg/kg, bw) or combination of both for 36 days, respectively (n = 8/group). Another eight healthy and CIA rats served as normal and model control, respectively. Therapeutic effects were evaluated based on paw edema and arthritis score during the experiment and serological markers at the end of the study period. Histological and radiological examinations were used to assess joint destructions. The immune status was investigated by immunohistochemistry and flow cytometry. Results: All treatments decreased the arthritis score and paw inflammation in CIA rats. Combination regimen significantly reduced anti-cyclic citrullinated peptide antibody in CIA rats to 85.83% (p
- Published
- 2018
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49. Research on modeling and identification of machine tool joint dynamic characteristics
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Qin YIN, Guanhua DONG, Guofu YIN, Liang HENG, and Ling WANG
- Subjects
dynamic stiffness ,joint ,joint identification ,modeling ,frequency response function ,Engineering machinery, tools, and implements ,TA213-215 ,Mechanical engineering and machinery ,TJ1-1570 - Abstract
The dynamic characteristics of a joint affect the machine tool operations notably. In this paper, an improved approach is proposed to identify the dynamic stiffness of the joint and to construct a relevant dynamic model. The theoretical dynamic model assembled of two beams is built using the frequency response functions. The identification formulas are derived based on the mechanical equilibrium condition and the displacement compatibility condition to describe the relationship between the assembled structures and substructures. Then an inconsistent equation containing the identification relationship is developed. The equivalent value of the dynamic stiffness is extracted employing the least square method. In the identification process, a part of frequency response functions, which is difficult to be measured, is considered as an intermediate variable to avoid introducing errors. According to the results, the calculated dynamic responses of the assembly show better agreement with the experimental measured data in comparison with the results derived from a typical method, which validates the feasibility. And the results demonstrate higher accuracy of the proposed method.
- Published
- 2019
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50. Sound absorption performance of the acoustic absorber fabricated by compression and microperforation of the porous metal
- Author
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Panfeng Bai, Xiaocui Yang, Xinmin Shen, Xiaonan Zhang, Zhizhong Li, Qin Yin, Guoliang Jiang, and Fei Yang
- Subjects
Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Novel acoustic absorbers were fabricated by the compression and microperforation of the porous metal, which aimed to develop practical acoustic absorbers for the noise reduction. Sound absorbing coefficients of the five investigated acoustic absorbers were measured by the AWA6128A detector according to the standing wave method, and their trends were consistent with normal sound absorption principle of the porous metal absorber and that of the microperforated panel absorber. The results proved that with same length of the cavity, sound absorption performance could be obviously improved by the compression and microperforation. When length of the cavity was 20 mm, average sound absorbing coefficient of the compressed and microperforated porous metal panel absorber in frequency range 100–6000 Hz reached 59.69%, which was superior to that 25.70% of original porous metal absorber and that 31.49% of the microperforated spring steel panel absorber. In the constructed semi-empirical model, a fourth-order polynomial function was treated as the coupling function to express the superposition absorption effect, and its veracity and reliability was validated by two replication experiments. Micromorphology of the compressed and microperforated porous metal panel provided the intuitive explanations to the improvement of its sound absorption performance. Keywords: Sound absorption performance, Porous metal, Compression, Microperforation, Superposition absorption effect, Micromorphology
- Published
- 2019
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