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279 results on '"Qin Lingling"'

1. Prognostic impacts of marital status on patients with buccal mucosa squamous cell carcinoma

Author

QIN Lingling, CHEN Ying, SU Miao, and ZHANG Hanbin

Subjects
buccal mucosa squamous cell carcinoma，, marital status，, married，, never married，, unhappily married，, survival，, mortality risk，, seer database，, social psychological factor，, Medicine
Abstract

Objective To explore the influence of marital status on the survival of patients with buccal mucosa squamous cell carcinoma (BMSCC) and to provide a scientific basis for risk assessment and nursing decisions for these patients. Methods A total of 1 006 BMSCC participants were identified in the Surveillance, Epidemiology, and End Results(SEER) database. Kaplan-Meier analysis was used to evaluate the effect of marital status (married, unmarried and unhappily married) on the survival of patients with buccal squamous cell carcinoma. The independent prognostic effect of marital status was further determined by univariate and multivariate Cox proportional hazard regression analysis.Results Marital status was an independent prognostic factor for BMSCC patients (P=0.001). Married patients had the best survival, while separated/divorced/widowed patients had the worst survival (HR=1. 445, P=0.001), and never married patients had an intermediate risk (HR=1.297, P=0.040).Conclusion Marital status was an independent prognostic factor for BMSCC patients. Unmarried and unhappily married patients had worse survival, which suggests that we should pay more attention to patients’ marital status, especially unmarried and unhappily married patients.

Published
2020
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24. Dioscin Ameliorates Experimental Autoimmune Thyroiditis via the mTOR and TLR4/NF-κB Signaling

Author

Zhang,Chengfei, Zhang,Qiue, Qin,Lingling, Yan,Zhiyi, Wu,Lili, Liu,Tonghua, Zhang,Chengfei, Zhang,Qiue, Qin,Lingling, Yan,Zhiyi, Wu,Lili, and Liu,Tonghua

Abstract

Chengfei Zhang,1,2,* Qiue Zhang,3,* Lingling Qin,4,* Zhiyi Yan,5 Lili Wu,4,5 Tonghua Liu5 1School of Life Sciences, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 3School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 4Technology Department, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 5Key Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese Medicine, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tonghua Liu, Key Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese Medicine, Beijing, People’s Republic of China, Email thliu@vip.163.comBackground: Autoimmune thyroiditis (AIT) is a common autoimmune disease that causes thyroid dysfunction. Clinical symptoms in Hashimoto thyroiditis patients were improved after oral administration of dioscin. However, the mechanisms involved in the therapeutic effect remain unclear.Methods: The protective effects and potential mechanisms of dioscin for autoimmune thyroiditis were explored in a rat model of thyroglobulin-induced autoimmune thyroiditis. Firstly, the rat model of AIT was obtained by subcutaneous injection of thyroglobulin and drinking the sodium iodide solution, followed by gavage administration for 8 weeks. Rats were sacrificed after anaesthesia, serum and thyroid samples were preserved. Serum triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin (TSH), thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb), and thyrotropin receptor antibody (TRAb) expressions were measured by enzyme-linked immunosorbent assay (ELISA). Morphological changes were observed by H&E stai

Published
2023

43. Elliptically polarized high-order harmonic generation in nitrogen molecules with cross-linearly polarized two-color laser fields.

Author

Zhai, Chunyang, Wu, Yinmeng, Qin, Lingling, Li, Xiang, Shi, Luke, Zhang, Ke, Kang, Shuaijie, Li, Zhengfa, Li, Yingbin, Tang, Qingbin, and Yu, Benhai

Subjects
HARMONIC generation, ATTOSECOND pulses, MOLECULAR orientation, LASERS, NITROGEN, MOLECULES
Abstract

Circularly and elliptically polarized high-order harmonics have unique advantages when used in studying the chiral and magnetic features of matter. Here, we studied the polarization properties of high-order harmonics generated from alignment nitrogen molecules driven by cross-linearly polarized two-color laser fields. Through adjusting various laser parameters and targets, such as the relative phase, the crossing angle, the intensity ratio of the driving fields, and the molecular alignment angle, we obtained highly elliptically polarized high-order harmonics with the same helicity in a wide spectral range. This provides a possible effective way to generate elliptically polarized attosecond pulses. Finally, we showed the probability of controlling the spectral range of elliptically polarized harmonics. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Single-Cell Transcriptomics Uncovers Cellular Heterogeneity, Mechanisms, and Therapeutic Targets for Parkinson’s Disease

Author

Huang, Jianjun, Liu, Li, Qin, Lingling, Huang, Hehua, and Li, Xue

Subjects
Genetics, Molecular Medicine, Genetics (clinical)
Abstract

Objective: This study aimed to exploit cellular heterogeneity for revealing mechanisms and identifying therapeutic targets for Parkinson’s disease (PD) via single-cell transcriptomics.Methods: Single-cell RNA sequencing (scRNA-seq) data on midbrain specimens from PD and healthy individuals were obtained from the GSE157783 dataset. After quality control and preprocessing, the principal component analysis (PCA) was presented. Cells were clustered with the Seurat package. Cell clusters were labeled by matching marker genes and annotations of the brain in the CellMarker database. The ligand–receptor networks were established, and the core cell cluster was selected. Biological functions of differentially expressed genes in core cell clusters were analyzed. Upregulated marker genes were identified between PD and healthy individuals, which were measured in 18 PD patients’ and 18 healthy individuals’ blood specimens through RT-qPCR and Western blotting.Results: The first nine PCs were determined, which can better represent the overall change. Five cell clusters were identified, including oligodendrocytes, astrocytes, neurons, microglial cells, and endothelial cells. Among them, endothelial cells were the core cell cluster in the ligand–receptor network. Marker genes of endothelial cells possessed various biological functions. Among them, five marker genes (ANGPT2, APOD, HSP90AA1, HSPA1A, and PDE1C) were upregulated in PD patients’ than in healthy individuals’ endothelial cells, which were confirmed in PD patients’ than in healthy individuals’ blood specimens.Conclusion: Our findings revealed that the cellular heterogeneity of PD and endothelial cells could play a major role in cell-to-cell communications. Five upregulated marker genes of endothelial cells could be underlying therapeutic targets of PD, which deserve more in-depth clinical research.

Published
2022

48. Additional file 1 of Zishen Pill alleviates diabetes in Db/db mice via activation of PI3K/AKT pathway in the liver

Author

Wu, You, Sun, Boju, Guo, Xiaoyuan, Wu, Lili, Hu, Yaomu, Qin, Lingling, Yang, Tao, Li, Mei, Qin, Tianyu, Jiang, Miao, and Liu, Tonghua

Abstract

Additional file 1 Table S1. Elution program used in the UPLC system. Table S2. Primers used in qPCR analysis. Table S3. Characteristic chemicals identified from LC-MS/MS analysis. figure S1. ZSP showed no severe toxic effects on mice. a Food intake and water intake of mice (n=7). b Body length of mice (n=7). c Assessment of liver function of mice (n=7). Normal group: wt/wt mice treated with distilled water. Model group: db/db mice treated with distilled water. ZSP group: db/db mice treated with ZSP at 3.3g/kg/day. All data presented as mean ± SD. *p < 0.05, **p < 0.01, ***p

Published
2022
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