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2. Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

Author

Ding, Yi, Xu, Xiaoli, Xin, Zhuojun, Cao, Qiuyu, Huang, Jiaojiao, Wu, Xianglin, Huo, Yanan, Wan, Qin, Qin, Yingfen, Hu, Ruying, Shi, Lixin, Su, Qing, Yu, Xuefeng, Yan, Li, Qin, Guijun, Tang, Xulei, Chen, Gang, Xu, Min, Wang, Tiange, Zhao, Zhiyun, Gao, Zhengnan, Wang, Guixia, Shen, Feixia, Luo, Zuojie, Chen, Li, Li, Qiang, Ye, Zhen, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Yang, Tao, Deng, Huacong, Chen, Lulu, Zeng, Tianshu, Zhao, Jiajun, Mu, Yiming, Wu, Shengli, Chen, Yuhong, Lu, Jieli, Wang, Weiqing, Ning, Guang, Xu, Yu, Bi, Yufang, and Li, Mian

Published
2024
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4. Association of social determinants, lifestyle, and metabolic factors with mortality in Chinese adults: A nationwide 10-year prospective cohort study

Author

Lu, Jieli, Li, Mian, He, Jiang, Xu, Yu, Zheng, Ruizhi, Zheng, Jie, Qin, Guijun, Qin, Yingfen, Chen, Yuhong, Tang, Xulei, Ye, Zhen, Xu, Min, Wang, Tiange, Shi, Lixin, Su, Qing, Yu, Xuefeng, Yan, Li, Zhao, Zhiyun, Wan, Qin, Chen, Gang, Gao, Zhengnan, Wang, Guixia, Shen, Feixia, Gu, Xuejiang, Luo, Zuojie, Chen, Li, Hou, Xinguo, Huo, Yanan, Li, Qiang, Qiao, Hong, Zhang, Yinfei, Zeng, Tianshu, Hu, Chunyan, Cao, Qiuyu, Jia, Xiaojing, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Deng, Huacong, Qi, Hongyan, Wu, Xueyan, Zhang, Di, Dai, Meng, Li, Donghui, Lai, Shenghan, Chen, Lulu, Zhao, Jiajun, Mu, Yiming, Hu, Weiguo, Ning, Guang, Hu, Ruying, Bi, Yufang, and Wang, Weiqing

Published
2024
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5. Association of circulating long-chain free fatty acids and incident diabetes risk among normoglycemic Chinese adults: a prospective nested case–control study

Author

Wang, Shuangyuan, Hu, Chunyan, Lin, Hong, Jia, Xiaojing, Hu, Ruying, Zheng, Ruizhi, Li, Mian, Xu, Yu, Xu, Min, Zheng, Jie, Zhao, Xinjie, Li, Yanli, Chen, Lulu, Zeng, Tianshu, Ye, Zhen, Shi, Lixin, Su, Qing, Chen, Yuhong, Yu, Xuefeng, Yan, Li, Wang, Tiange, Zhao, Zhiyun, Qin, Guijun, Wan, Qin, Chen, Gang, Dai, Meng, Zhang, Di, Qiu, Bihan, Zhu, Xiaoyan, Liu, Ruixin, Wang, Xiao, Tang, Xulei, Gao, Zhengnan, Shen, Feixia, Gu, Xuejiang, Luo, Zuojie, Qin, Yingfen, Chen, Li, Hou, Xinguo, Huo, Yanan, Li, Qiang, Wang, Guixia, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Deng, Huacong, Zhao, Jiajun, Mu, Yiming, Xu, Guowang, Lai, Shenghan, Li, Donghui, Ning, Guang, Wang, Weiqing, Bi, Yufang, and Lu, Jieli

Published
2024
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6. Early adulthood weight change, midlife “Life’s essential 8” health status and risk of cardiometabolic diseases: a chinese nationwide cohort study

Author

Cao, Qiuyu, Li, Mian, Qin, Guijun, Yan, Li, He, Jiang, Xu, Min, Xu, Yu, Wang, Tiange, Chen, Yuhong, Wang, Shuangyuan, Lin, Hong, Zhao, Zhiyun, Gao, Zhengnan, Zeng, Tianshu, Hu, Ruying, Yu, Xuefeng, Chen, Gang, Su, Qing, Mu, Yiming, Chen, Lulu, Tang, Xulei, Wan, Qin, Wang, Guixia, Shen, Feixia, Luo, Zuojie, Qin, Yingfen, Chen, Li, Huo, Yanan, Li, Qiang, Ye, Zhen, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Deng, Huacong, Zhao, Jiajun, Shi, Lixin, Ning, Guang, Wang, Weiqing, Lu, Jieli, and Bi, Yufang

Published
2023
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7. Phenotypically Male Congenital Adrenal Hyperplasia Patient with Huge Space-occupying Adrenal Masses: a Case Report and Literature Review

Author

RAO Yufeng, MENG Liheng, ZHOU Jia, LIANG Xinghuan, HUANG Zhenxing, QIN Yingfen

Subjects
adrenocortical adenoma, steroid 21-hydroxylase, glucocorticoids, gender identity, case reports, Medicine
Abstract

Congenital adrenal hyperplasia (CAH) is an autosomal recessive genetic disease encompassing enzyme deficiencies in the process of adrenal steroidogenesis, which leads to adrenal cortex dysfunction. Hypersecretion of corticotrophin-releasing hormone and insufficient cortisol production often lead to enlarged adrenal glands. Existing studies have reported that most of space-occupying adrenal masses in CAH are benign, only very few are malignant. It is difficult for clinicians to distinguish the nature of space-occupying adrenal masses, and physicians have insufficient experiences in treating the disease. We reported a phenotypically male case of CAH with huge space-occupying adrenal masses and reviewed relevant literature, aiming to provide evidence on the diagnosis and treatment of this disease for clinicians. The space-occupying adrenal masses in CAH often show tumor-like hyperplasia before diagnosis and treatment or effective hormone replacement therapy, but most of them will be significantly reduced or disappear after glucocorticoid replacement therapy. But a follow-up of several years showed that space-occupying adrenal masses in the CAH patient encountered by us had no significant changes and no significant impact on the patient's body, even without effective drug intervention.

Published
2023
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8. Data-driven subgroups of prediabetes and the associations with outcomes in Chinese adults

Author

Zheng, Ruizhi, Xu, Yu, Li, Mian, Gao, Zhengnan, Wang, Guixia, Hou, Xinguo, Chen, Li, Huo, Yanan, Qin, Guijun, Yan, Li, Wan, Qin, Zeng, Tianshu, Chen, Lulu, Shi, Lixin, Hu, Ruying, Tang, Xulei, Su, Qing, Yu, Xuefeng, Qin, Yingfen, Chen, Gang, Gu, Xuejiang, Shen, Feixia, Luo, Zuojie, Chen, Yuhong, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Li, Qiang, Mu, Yiming, Zhao, Jiajun, Hu, Chunyan, Jia, Xiaojing, Xu, Min, Wang, Tiange, Zhao, Zhiyun, Wang, Shuangyuan, Lin, Hong, Ning, Guang, Wang, Weiqing, Lu, Jieli, and Bi, Yufang

Published
2023
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9. Risk of cardiovascular disease, death, and renal progression in diabetes according to albuminuria and estimated glomerular filtration rate

Author

Niu, Jingya, Zhang, Xiaoyun, Li, Mian, Wu, Shujing, Zheng, Ruizhi, Chen, Li, Huo, Yanan, Xu, Min, Wang, Tiange, Zhao, Zhiyun, Wang, Shuangyuan, Lin, Hong, Qin, Guijun, Yan, Li, Wan, Qin, Chen, Lulu, Shi, Lixin, Hu, Ruying, Tang, Xulei, Su, Qing, Yu, Xuefeng, Qin, Yingfen, Chen, Gang, Gao, Zhengnan, Wang, Guixia, Shen, Feixia, Luo, Zuojie, Chen, Yuhong, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Li, Qiang, Mu, Yiming, Zhao, Jiajun, Bi, Yufang, Ning, Guang, Wang, Weiqing, Lu, Jieli, and Xu, Yu

Published
2023
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10. Association between triglyceride glucose index and breast cancer in 142,184 Chinese adults: findings from the REACTION study

Author

Wu, Xueyan, primary, Wang, Shuangyuan, additional, Lin, Lin, additional, Jia, Xiaojing, additional, Hu, Chunyan, additional, Qi, Hongyan, additional, Lin, Hong, additional, Zheng, Ruizhi, additional, Li, Mian, additional, Xu, Yu, additional, Xu, Min, additional, Chen, Lulu, additional, Zeng, Tianshu, additional, Hu, Ruying, additional, Ye, Zhen, additional, Shi, Lixin, additional, Su, Qing, additional, Yu, Xuefeng, additional, Yan, Li, additional, Wang, Tiange, additional, Zhao, Zhiyun, additional, Zheng, Jie, additional, Qin, Guijun, additional, Wan, Qin, additional, Chen, Gang, additional, Dai, Meng, additional, Tang, Xulei, additional, Gao, Zhengnan, additional, Shen, Feixia, additional, Gu, Xuejiang, additional, Luo, Zuojie, additional, Qin, Yingfen, additional, Chen, Li, additional, Hou, Xinguo, additional, Huo, Yanan, additional, Li, Qiang, additional, Wang, Guixia, additional, Zhang, Yinfei, additional, Liu, Chao, additional, Wang, Youmin, additional, Wu, Shengli, additional, Yang, Tao, additional, Deng, Huacong, additional, Zhao, Jiajun, additional, Mu, Yiming, additional, Ning, Guang, additional, Wang, Weiqing, additional, Bi, Yufang, additional, Chen, Yuhong, additional, and Lu, Jieli, additional

Published
2024
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11. Amino acids, microbiota-related metabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study

Author

Wang, Shuangyuan, Li, Mian, Lin, Hong, Wang, Guixia, Xu, Yu, Zhao, Xinjie, Hu, Chunyan, Zhang, Yi, Zheng, Ruizhi, Hu, Ruying, Shi, Lixin, Du, Rui, Su, Qing, Wang, Jiqiu, Chen, Yuhong, Yu, Xuefeng, Yan, Li, Wang, Tiange, Zhao, Zhiyun, Liu, Ruixin, Wang, Xiaolin, Li, Qi, Qin, Guijun, Wan, Qin, Chen, Gang, Xu, Min, Dai, Meng, Zhang, Di, Tang, Xulei, Gao, Zhengnan, Shen, Feixia, Luo, Zuojie, Qin, Yingfen, Chen, Li, Huo, Yanan, Li, Qiang, Ye, Zhen, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Deng, Huacong, Zhao, Jiajun, Lai, Shenghan, Mu, Yiming, Chen, Lulu, Li, Donghui, Xu, Guowang, Ning, Guang, Wang, Weiqing, Bi, Yufang, and Lu, Jieli

Published
2022
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12. Association of soy food with cardiovascular outcomes and all-cause mortality in a Chinese population: a nationwide prospective cohort study

Author

Xue, Ting, Wen, Junping, Wan, Qin, Qin, Guijun, Yan, Li, Wang, Guixia, Qin, Yingfen, Luo, Zuojie, Tang, Xulei, Huo, Yanan, Hu, Ruying, Ye, Zhen, Shi, Lixin, Gao, Zhengnan, Su, Qing, Mu, Yiming, Zhao, Jiajun, Chen, Lulu, Zeng, Tianshu, Yu, Xuefeng, Li, Qiang, Shen, Feixia, Chen, Li, Zhang, Yinfei, Wang, Youmin, Deng, Huacong, Liu, Chao, Wu, Shengli, Yang, Tao, Li, Mian, Xu, Yu, Xu, Min, Wang, Tiange, Zhao, Zhiyun, Lu, Jieli, Bi, Yufang, Wang, Weiqing, Chen, Gang, and Ning, Guang

Published
2022
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13. Interaction between smoking and diabetes in relation to subsequent risk of cardiovascular events

Author

Yang, Yang, Peng, Nianchun, Chen, Gang, Wan, Qin, Yan, Li, Wang, Guixia, Qin, Yingfen, Luo, Zuojie, Tang, Xulei, Huo, Yanan, Hu, Ruying, Ye, Zhen, Qin, Guijun, Gao, Zhengnan, Su, Qing, Mu, Yiming, Zhao, Jiajun, Chen, Lulu, Zeng, Tianshu, Yu, Xuefeng, Li, Qiang, Shen, Feixia, Chen, Li, Zhang, Yinfei, Wang, Youmin, Deng, Huacong, Liu, Chao, Wu, Shengli, Yang, Tao, Li, Mian, Xu, Yu, Xu, Min, Zhao, Zhiyun, Wang, Tiange, Lu, Jieli, Bi, Yufang, Wang, Weiqing, Ning, Guang, Zhang, Qiao, and Shi, Lixin

Published
2022
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14. Hypertension Defined by 2017 ACC/AHA Guideline, Ideal Cardiovascular Health Metrics, and Risk of Cardiovascular Disease: A Nationwide Prospective Cohort Study

Author

Wu, Shujing, Xu, Yu, Zheng, Ruizhi, Lu, Jieli, Li, Mian, Chen, Li, Huo, Yanan, Xu, Min, Wang, Tiange, Zhao, Zhiyun, Wang, Shuangyuan, Lin, Hong, Dai, Meng, Zhang, Di, Niu, Jingya, Qin, Guijun, Yan, Li, Wan, Qin, Chen, Lulu, Shi, Lixin, Hu, Ruying, Tang, Xulei, Su, Qing, Yu, Xuefeng, Qin, Yingfen, Chen, Gang, Gao, Zhengnan, Wang, Guixia, Shen, Feixia, Luo, Zuojie, Chen, Yuhong, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Li, Qiang, Mu, Yiming, Zhao, Jiajun, Bi, Yufang, Wang, Weiqing, and Ning, Guang

Published
2022
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15. Abnormal brain regional activity in acute thyrotoxic myopathy assessed by resting-state functional MRI.

Author

Kuang, Yaqi, Liang, Xinghuan, Ye, Wei, Fu, Shien, Qin, Yingfen, Ma, Yan, and Luo, Zuojie

Abstract

Background: The neurophysiological mechanisms underlying manifestations of bulbar paralysis in acute thyrotoxic myopathy (ATM) and the afflicted brain areas are unclear. Purpose: We used resting-state functional magnetic resonance imaging (rs-fMRI) to evaluate the regional brain activities in patients with ATM. Material and Methods: In total, 16 patients with ATM, 16 patients with hyperthyroidism without ATM, and 16 healthy controls underwent functional MRI scans. By calculating the fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC), we assessed variations in resting-state cerebral activity. The correlation between the resting-state functional indexes and clinical assessments was also explored. Results: Compared to the hyperthyroid patients, patients with ATM had stronger ReHo in the left precentral gyrus, reduced ReHo in the left orbitofrontal gyrus (OFG), and decreased FC in the left precentral gyri, left superior frontal gyrus (SFG), and left middle frontal gyrus (MFG). Patients with ATM showed reduced fALFF and ReHo in the right SFG and decreased ReHo in the bilateral supplementary motor area (SMA). A significantly decreased FC in the left SFG and left MFG, right precentral gyrus, and the orbital part of the right interior frontal gyrus was observed in patients with ATM compared to healthy controls. Additionally, fALFF and ReHo values were positively correlated with serum thyroid-related hormones and antibodies. Conclusion: The findings of rs-fMRI demonstrate that particular brain regions' functional activity was aberrant in individuals with ATM, especially in SFG area. This finding may help with better understanding of underlying pathophysiology of patients with ATM. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Examining the Linear Association Between Blood Pressure Levels and Cardiovascular Diseases in the Absence of Major Risk Factors in China

Author

Zheng, Ruizhi, Xu, Yu, Li, Mian, Lu, Jieli, Wu, Shujing, Niu, Jingya, Zhao, Zhiyun, Chen, Li, Huo, Yanan, Xu, Min, Wang, Tiange, Wang, Shuangyuan, Lin, Hong, Qin, Guijun, Yan, Li, Wan, Qin, Chen, Lulu, Shi, Lixin, Hu, Ruying, Tang, Xulei, Su, Qing, Yu, Xuefeng, Qin, Yingfen, Chen, Gang, Gao, Zhengnan, Wang, Guixia, Shen, Feixia, Luo, Zuojie, Chen, Yuhong, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Li, Qiang, Mu, Yiming, Zhao, Jiajun, Wang, Weiqing, Ning, Guang, and Bi, Yufang

Published
2022
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17. Age-specific modifiable risk factor profiles for cardiovascular disease and all-cause mortality: a nationwide, population-based, prospective cohort study

Author

Wang, Tiange, Zhao, Zhiyun, Yu, Xuefeng, Zeng, Tianshu, Xu, Min, Xu, Yu, Hu, Ruying, Chen, Gang, Su, Qing, Mu, Yiming, Chen, Lulu, Tang, Xulei, Yan, Li, Qin, Guijun, Wan, Qin, Gao, Zhengnan, Wang, Guixia, Shen, Feixia, Luo, Zuojie, Qin, Yingfen, Chen, Li, Huo, Yanan, Li, Qiang, Ye, Zhen, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Deng, Huacong, Zhao, Jiajun, Xu, Yiping, Li, Mian, Chen, Yuhong, Wang, Shuangyuan, Ning, Guang, Bi, Yufang, Shi, Lixin, Lu, Jieli, and Wang, Weiqing

Published
2021
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19. Non-alcoholic fatty liver disease, metabolic goal achievement with incident cardiovascular disease and eGFR-based chronic kidney disease in patients with prediabetes and diabetes

Author

Li, Mian, Zhao, Zhiyun, Qin, Guijun, Chen, Li, Lu, Jieli, Huo, Yanan, Chen, Lulu, Zeng, Tianshu, Xu, Min, Chen, Yuhong, Wang, Tiange, Wang, Shuangyuan, Xu, Yiping, Shi, Lixin, Tang, Xulei, Su, Qing, Yu, Xuefeng, Yan, Li, Wan, Qin, Chen, Gang, Gao, Zhengnan, Wang, Guixia, Shen, Feixia, Luo, Zuojie, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Hu, Ruying, Ye, Zhen, Wu, Shengli, Deng, Huacong, Yang, Tao, Li, Qiang, Qin, Yingfen, Mu, Yiming, Zhao, Jiajun, Ning, Guang, Bi, Yufang, Xu, Yu, and Wang, Weiqing

Published
2021
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20. The Correlation Between Metabolic Disorders And Tpoab/Tgab: A Cross-Sectional Population-Based Study

Author

Wu, Ying, Shi, Xiaoguang, Tang, Xulei, Li, Yongze, Tong, Nanwei, Wang, Guixia, Zhang, Jin-an, Wang, Youmin, Ba, Jianming, Chen, Bing, Du, Jianling, He, Lanjie, Lai, Xiaoyang, Li, Yanbo, Chi, Haiyi, Liao, Eryuan, Liu, Chao, Liu, Libin, Qin, Guijun, Qin, Yingfen, Quan, Huibiao, Shi, Bingyin, Sun, Hui, Xue, Yuanming, Yan, Li, Yang, Jing, Yang, Lihui, Yao, Yongli, Ye, Zhen, Zhang, Qiao, Zhang, Lihui, Zhu, Jun, Zhu, Mei, Teng, Weiping, and Shan, Zhongyan

Published
2020
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21. Association of insulin resistance and β-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study

Author

Wang, Tiange, Lu, Jieli, Shi, Lixin, Chen, Gang, Xu, Min, Xu, Yu, Su, Qing, Mu, Yiming, Chen, Lulu, Hu, Ruying, Tang, Xulei, Yu, Xuefeng, Li, Mian, Zhao, Zhiyun, Chen, Yuhong, Yan, Li, Qin, Guijun, Wan, Qin, Dai, Meng, Zhang, Di, Gao, Zhengnan, Wang, Guixia, Shen, Feixia, Luo, Zuojie, Qin, Yingfen, Chen, Li, Huo, Yanan, Li, Qiang, Ye, Zhen, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Deng, Huacong, Zhao, Jiajun, Lai, Shenghan, Bi, Yufang, DeFronzo, Ralph A, Wang, Weiqing, and Ning, Guang

Published
2020
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22. The Association between Educational Attainment and the Risk of Nonalcoholic Fatty Liver Disease among Chinese Adults: Findings from the REACTION Study

Author

Zhu, Yuanyue, primary, Wang, Long, additional, Lin, Lin, additional, Huo, Yanan, additional, Wan, Qin, additional, Qin, Yingfen, additional, Hu, Ruying, additional, Shi, Lixin, additional, Su, Qing, additional, Yu, Xuefeng, additional, Yan, Li, additional, Qin, Guijun, additional, Tang, Xulei, additional, Chen, Gang, additional, Wang, Shuangyuan, additional, Lin, Hong, additional, Wu, Xueyan, additional, Hu, Chunyan, additional, Li, Mian, additional, Xu, Min, additional, Xu, Yu, additional, Wang, Tiange, additional, Zhao, Zhiyun, additional, Gao, Zhengnan, additional, Wang, Guixia, additional, Shen, Feixia, additional, Gu, Xuejiang, additional, Luo, Zuojie, additional, Chen, Li, additional, Li, Qiang, additional, Ye, Zhen, additional, Zhang, Yinfei, additional, Liu, Chao, additional, Wang, Youmin, additional, Wu, Shengli, additional, Yang, Tao, additional, Deng, Huacong, additional, Chen, Lulu, additional, Zeng, Tianshu, additional, Zhao, Jiajun, additional, Mu, Yiming, additional, Wang, Weiqing, additional, Ning, Guang, additional, Bi, Yufang, additional, Chen, Yuhong, additional, and Lu, Jieli, additional

Published
2024
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24. A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China

Author

Lu, Xixuan, Shi, Xiaoguang, Li, Yanbo, Chi, Haiyi, Liao, Eryuan, Liu, Chao, Liu, Libin, Li, Yongze, Teng, Di, Teng, Xiaochun, Ba, Jianming, Chen, Bing, Du, Jianling, He, Lanjie, Lai, Xiaoyang, Qin, Guijun, Qin, Yingfen, Quan, Huibiao, Shi, Bingyin, Sun, Hui, Tang, Xulei, Tong, Nanwei, Wang, Guixia, Zhang, Jin-an, Wang, Youmin, Xue, Yuanming, Yan, Li, Yang, Jing, Yang, Lihui, Yao, Yongli, Ye, Zhen, Zhang, Qiao, Zhang, Lihui, Zhu, Jun, Zhu, Mei, Shan, Zhongyan, and Teng, Weiping

Published
2020
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26. The potential causal association between systemic lupus erythematosus and endocrine and metabolic disorders in the East Asian population: A bidirectional two-sample Mendelian randomization study.

Author

Wang, Tingliang, Zhang, Yun, Chen, Xuelan, Huang, Zhenxing, Liang, Xinghuan, Qin, Yingfen, and Luo, Zuojie

Subjects
EAST Asians, SYSTEMIC lupus erythematosus, ENDOCRINE diseases, METABOLIC disorders, TYPE 2 diabetes
Abstract

Objectives: Observational studies indicate a significant correlation between systemic lupus erythematosus (SLE) and endocrine and metabolic disorders, but the causal association between SLE and endocrine and metabolic disorders remains unclear due to the reverse causality and confounding biases commonly presented in conventional observational research. This study endeavors to uncover the causal association between SLE and three common endocrine and metabolic disorders, including Graves' disease (GD), type 2 diabetes mellitus (T2DM), and osteoporosis (OP). Methods: We used genome-wide association study data for SLE and three endocrine and metabolic disorders in an East Asian population, employing bidirectional two-sample Mendelian randomization (MR) analysis and sensitivity analysis to ascertain the causal association between SLE and endocrine and metabolic disorders. Results: A multiplicative random-effect inverse-variance weighted approach revealed a significant positive correlation between SLE and an elevated risk of GD with an odds ratio (OR) of 1.12 (95% CI: 1.04–1.22, p <.01), and inverse-variance weighted (IVW) analysis also indicated that SLE increased the risk of OP with an OR of 1.035 (95% CI: 1.003–1.068, p <.05). Additionally, GD causally affected SLE in an IVW analysis after Bonferroni correction, with an OR of 1.33 (95% CI: 1.19–1.49, p <.05/3), but the application of multivariable MR analysis resulted in the absence of a causal association of GD on SLE (OR 1.047, 95% CI: 0.952–1.151, p >.05). Lastly, the robustness and validity of the findings were verified through a sensitivity analysis. Conclusions: We confirmed that SLE has a causal effect on GD as well as OP, but no evidence exists to substantiate a causal link between SLE and T2DM. Our study offers valuable contributions for uncovering the etiology of SLE and endocrine and metabolic disorders and furthering disease risk research while providing potential targets for disease monitoring and therapeutic intervention. [ABSTRACT FROM AUTHOR]

Published
2024
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29. The mystery of transient pregnancy-induced cushing’s syndrome: a case report and literature review highlighting GNASsomatic mutations and LHCGR overexpression

Author

Li, Yufei, Lin, Jianfan, Fu, Shien, Li, Li, Huang, Zhenxing, Yang, Haiyan, Liang, Xinghuan, Qin, Yingfen, Zhou, Jia, Liu, Deyun, and Luo, Zuojie

Abstract

Purpose: Transient pregnancy-induced Cushing’s syndrome is a rare condition characterized by the manifestation of symptoms solely during pregnancy, which typically resolve spontaneously following delivery or miscarriage. While it has been established that GNASis associated with adrenal tumors, its specific role in the pathogenesis of pregnancy-induced Cushing’s syndrome remains uncertain.This work aims to examine the association between GNASmutation and pregnancy-induced Cushing’s syndrome. Methods: DNA was extracted from patients’ peripheral blood and tumor tissues for whole-exome sequencing (WES) and Sanger sequencing. We used AlphaFold to predict the protein structure of wild-type and mutant GNASand to make functional predictions, and immunohistochemistry was used to detect disease-associated protein expression. A review and summary of reported cases of transient pregnancy-induced Cushing’s syndrome induced by pregnancy was conducted. Results: Using WES, we identified a somatic mutation in GNAS(NM_000516, c.C601T, p.R201C) that was predicted to have a deleterious effect using computational methods, such as AlphaFold. Human chorionic gonadotropin (hCG) stimulation tests had weakly positive results, and immunohistochemical staining of adrenal adenoma tissue also revealed positivity for luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and cytochrome P450 family 11 subfamily B member 1 (CYP11B1). We reviewed 15 published cases of transient Cushing’s syndrome induced by pregnancy. Among these cases, immunohistochemical staining of the adrenal gland showed positive LHCGR expression in 3 case reports, similar to our findings. Conclusion: Transient pregnancy-induced Cushing’s syndrome may be associated with somatic GNASmutations and altered adrenal pathology due to abnormal activation of LHCGR.

Published
2024
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30. Blood Pressure Levels, Cardiovascular Events, and Renal Outcomes in Chronic Kidney Disease Without Antihypertensive Therapy: A Nationwide Population-Based Cohort Study

Author

Wu, Shujing, primary, Li, Mian, additional, Lu, Jieli, additional, Tang, Xulei, additional, Wang, Guixia, additional, Zheng, Ruizhi, additional, Niu, Jingya, additional, Chen, Li, additional, Huo, Yanan, additional, Xu, Min, additional, Wang, Tiange, additional, Zhao, Zhiyun, additional, Wang, Shuangyuan, additional, Lin, Hong, additional, Qin, Guijun, additional, Yan, Li, additional, Wan, Qin, additional, Chen, Lulu, additional, Shi, Lixin, additional, Hu, Ruying, additional, Su, Qing, additional, Yu, Xuefeng, additional, Qin, Yingfen, additional, Chen, Gang, additional, Gao, Zhengnan, additional, Shen, Feixia, additional, Luo, Zuojie, additional, Chen, Yuhong, additional, Zhang, Yinfei, additional, Liu, Chao, additional, Wang, Youmin, additional, Wu, Shengli, additional, Yang, Tao, additional, Li, Qiang, additional, Mu, Yiming, additional, Zhao, Jiajun, additional, Ning, Guang, additional, Bi, Yufang, additional, Wang, Weiqing, additional, Xu, Yu, additional, Li, Donghui, additional, Lai, Shenghan, additional, Bloomgarden, Zachary T., additional, Ye, Zhen, additional, and Deng, Huacong, additional

Published
2023
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31. U-shaped association between triglyceride and risk of incident diabetes in normoglycemic males with NAFLD: A population-base cohort study

Author

Xie, Xuemei, primary, Liao, Jixiang, additional, Huang, Chenghu, additional, Li, Xiaowei, additional, Cao, Qiuli, additional, Kong, Lijuan, additional, Okamura, Takuro, additional, Hashimoto, Yoshitaka, additional, Obora, Akihiro, additional, Kojima, Takao, additional, Fukui, Michiaki, additional, Hamaguchi, Masahide, additional, Luo, Zuojie, additional, Qin, Yingfen, additional, Liang, Xinghuan, additional, and Xuan, Xiuping, additional

Published
2023
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38. Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study

Author

Zhu, Yuanyue, primary, Hu, Chunyan, additional, Lin, Lin, additional, Wang, Shuangyuan, additional, Lin, Hong, additional, Huo, Yanan, additional, Wan, Qin, additional, Qin, Yingfen, additional, Hu, Ruying, additional, Shi, Lixin, additional, Su, Qing, additional, Yu, Xuefeng, additional, Yan, Li, additional, Qin, Guijun, additional, Tang, Xulei, additional, Chen, Gang, additional, Xu, Min, additional, Xu, Yu, additional, Wang, Tiange, additional, Zhao, Zhiyun, additional, Gao, Zhengnan, additional, Wang, Guixia, additional, Shen, Feixia, additional, Luo, Zuojie, additional, Chen, Li, additional, Li, Qiang, additional, Ye, Zhen, additional, Zhang, Yinfei, additional, Liu, Chao, additional, Wang, Youmin, additional, Wu, Shengli, additional, Yang, Tao, additional, Deng, Huacong, additional, Chen, Lulu, additional, Zeng, Tianshu, additional, Zhao, Jiajun, additional, Mu, Yiming, additional, Wang, Weiqing, additional, Ning, Guang, additional, Bi, Yufang, additional, Chen, Yuhong, additional, and Lu, Jieli, additional

Published
2022
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39. Se-Methylselenocysteine inhibits proliferation and migration of anaplastic thyroid carcinoma cells through the ROS-ERK1/2 signaling pathway

Author

Luo, Zuojie, primary, Ban, Bixiu, additional, Ma, Yan, additional, Yang, Haiyan, additional, Huang, Zhenxing, additional, Kuang, Yaqi, additional, Liu, Yuping, additional, Wu, Xizhen, additional, Lu, Decheng, additional, Li, Li, additional, Xian, Jing, additional, Qin, Yingfen, additional, and Liang, Xinghuan, additional

Published
2022
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40. Association Between Insulin Resistance and Cardiovascular Disease Risk Varies According to Glucose Tolerance Status: A Nationwide Prospective Cohort Study

Author

Wang, Tiange, primary, Li, Mian, additional, Zeng, Tianshu, additional, Hu, Ruying, additional, Xu, Yu, additional, Xu, Min, additional, Zhao, Zhiyun, additional, Chen, Yuhong, additional, Wang, Shuangyuan, additional, Lin, Hong, additional, Yu, Xuefeng, additional, Chen, Gang, additional, Su, Qing, additional, Mu, Yiming, additional, Chen, Lulu, additional, Tang, Xulei, additional, Yan, Li, additional, Qin, Guijun, additional, Wan, Qin, additional, Gao, Zhengnan, additional, Wang, Guixia, additional, Shen, Feixia, additional, Luo, Zuojie, additional, Qin, Yingfen, additional, Chen, Li, additional, Huo, Yanan, additional, Li, Qiang, additional, Ye, Zhen, additional, Zhang, Yinfei, additional, Liu, Chao, additional, Wang, Youmin, additional, Wu, Shengli, additional, Yang, Tao, additional, Deng, Huacong, additional, Zhao, Jiajun, additional, Shi, Lixin, additional, Ning, Guang, additional, Bi, Yufang, additional, Wang, Weiqing, additional, and Lu, Jieli, additional

Published
2022
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41. Modification effect of changes in cardiometabolic traits in association between kidney stones and cardiovascular events

Author

Xu, Min, primary, Zhao, Zhiyun, additional, Shen, Feixia, additional, Hu, Ruying, additional, Lu, Jieli, additional, Xu, Yu, additional, Wang, Tiange, additional, Li, Mian, additional, Chen, Gang, additional, Chen, Li, additional, Chen, Lulu, additional, Chen, Yuhong, additional, Deng, Huacong, additional, Gao, Zhengnan, additional, Huo, Yanan, additional, Li, Qiang, additional, Liu, Chao, additional, Luo, Zuojie, additional, Mu, Yiming, additional, Qin, Guijun, additional, Qin, Yingfen, additional, Shi, Lixin, additional, Su, Qing, additional, Wan, Qin, additional, Wang, Guixia, additional, Wang, Shuangyuan, additional, Wang, Youmin, additional, Wu, Shengli, additional, Xu, Yiping, additional, Yan, Li, additional, Yang, Tao, additional, Ye, Zhen, additional, Yu, Xuefeng, additional, Zhang, Yinfei, additional, Zhao, Jiajun, additional, Zeng, Tianshu, additional, Wang, Weiqing, additional, Bi, Yufang, additional, Tang, Xulei, additional, and Ning, Guang, additional

Published
2022
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42. The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study

Author

Xu, Min, primary, Qi, Yan, additional, Chen, Gang, additional, Qin, Yingfen, additional, Wu, Shengli, additional, Wang, Tiange, additional, Zhao, Zhiyun, additional, Xu, Yu, additional, Li, Mian, additional, Chen, Li, additional, Chen, Lulu, additional, Chen, Yuhong, additional, Deng, Huacong, additional, Gao, Zhengnan, additional, Huo, Yanan, additional, Li, Qiang, additional, Liu, Chao, additional, Luo, Zuojie, additional, Mu, Yiming, additional, Qin, Guijun, additional, Shen, Feixia, additional, Shi, Lixin, additional, Su, Qing, additional, Wan, Qin, additional, Wang, Guixia, additional, Wang, Shuangyuan, additional, Wang, Youmin, additional, Hu, Ruying, additional, Xu, Yiping, additional, Yan, Li, additional, Yang, Tao, additional, Yu, Xuefeng, additional, Zhang, Yinfei, additional, Zeng, Tianshu, additional, Tang, Xulei, additional, Ye, Zhen, additional, Zhao, Jiajun, additional, Bi, Yufang, additional, Ning, Guang, additional, Lu, Jieli, additional, and Wang, Weiqing, additional

Published
2022
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43. TSAb Modulates Microglia M1 Polarization via Activation of the TSHR-Mediated NF-κB Signaling Pathway.

Author

Liu, Yuping, Yang, Haiyan, Wu, Xizhen, Kuang, Yaqi, Ban, Bixiu, Liang, Ziyi, Li, Li, Huang, Zhenxing, Lu, Decheng, Qin, Yingfen, Liang, Xinghuan, and Luo, Zuojie

Subjects
THYROTROPIN receptors, TUMOR necrosis factors, NF-kappa B, MICROGLIA, NITRIC-oxide synthases, CELLULAR signal transduction, THYROID eye disease
Abstract

Introduction: Thyrotropin receptor-stimulating antibody (TSAb) is a pathogenic antibody in the serum of patients with Graves' disease. The binding of TSAb to thyroid-stimulating hormone receptor (TSHR) in non-thyroid tissue may be associated with the occurrence and development of Graves' disease-related complications. However, only few studies have been conducted on the effects of TSAb on the brain, and the pathogenesis of acute hyperthyroidism myopathy (ATM) is unclear. Therefore, this study aimed to explore the effect of TSAb on the polarization of BV-2 cells in the brain and its possible mechanism and provide a basic experimental basis for ATM. Methods: BV-2 cells were treated with different concentrations of TSAb. The relative survival rate of BV-2 cells was determined using the CCK-8 assay; the migration ability of BV-2 cells was detected using the Transwell migration assay; and the expression levels of M1/M2 polarization markers (CD86, inducible nitric oxide synthase [iNOS], CD206, and arginase 1 [Arg-1]), TSHR, tumor necrosis factor-alpha (TNF-α), and nuclear factor-kappa B (NF-κB) protein in BV-2 cells were measured using WB. Results: Compared with the negative control group, the proliferative activity of BV-2 cells was significantly increased in the 20, 50, and 100 ng/mL TSAb groups, and the migration ability of BV-2 cells was significantly enhanced in the 50 and 100 ng/mL TSAb groups. The expression levels of M1 polarization markers (CD86 and iNOS), TSHR, TNF-α, and NF-κB protein in BV-2 cells treated with 50 and 100 ng/mL TSAb for 24 h were significantly upregulated, whereas those of M2 polarization markers (CD206 and Arg-1) significantly decreased. Conclusions: TSAb can induce abnormal activation of microglia, polarize to the M1 phenotype, and promote the inflammatory cascade reaction, in which TSHR plays a key role in NF-κB activation and proinflammatory cytokine release. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Depression Status, Lifestyle, and Metabolic Factors With Subsequent Risk for Major Cardiovascular Events: The China Cardiometabolic Disease and Cancer Cohort (4C) Study

Author

Chen, Xi, primary, Liu, Zhelong, additional, Yang, Yan, additional, Chen, Gang, additional, Wan, Qin, additional, Qin, Guijun, additional, Yan, Li, additional, Wang, Guixia, additional, Qin, Yingfen, additional, Luo, Zuojie, additional, Tang, Xulei, additional, Huo, Yanan, additional, Hu, Ruying, additional, Ye, Zhen, additional, Shi, Lixin, additional, Gao, Zhengnan, additional, Su, Qing, additional, Mu, Yiming, additional, Zhao, Jiajun, additional, Chen, Lulu, additional, Zeng, Tianshu, additional, Li, Qiang, additional, Shen, Feixia, additional, Chen, Li, additional, Zhang, Yinfei, additional, Wang, Youmin, additional, Deng, Huacong, additional, Liu, Chao, additional, Wu, Shengli, additional, Yang, Tao, additional, Li, Mian, additional, Xu, Yu, additional, Xu, Min, additional, Wang, Tiange, additional, Zhao, Zhiyun, additional, Lu, Jieli, additional, Bi, Yufang, additional, Yu, Xuefeng, additional, Wang, Weiqing, additional, and Ning, Guang, additional

Published
2022
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48. Additional file 1 of Interaction between smoking and diabetes in relation to subsequent risk of cardiovascular events

Author

Yang, Yang, Peng, Nianchun, Chen, Gang, Wan, Qin, Yan, Li, Wang, Guixia, Qin, Yingfen, Luo, Zuojie, Tang, Xulei, Huo, Yanan, Hu, Ruying, Ye, Zhen, Qin, Guijun, Gao, Zhengnan, Su, Qing, Mu, Yiming, Zhao, Jiajun, Chen, Lulu, Zeng, Tianshu, Yu, Xuefeng, Li, Qiang, Shen, Feixia, Chen, Li, Zhang, Yinfei, Wang, Youmin, Deng, Huacong, Liu, Chao, Wu, Shengli, Yang, Tao, Li, Mian, Xu, Yu, Xu, Min, Zhao, Zhiyun, Wang, Tiange, Lu, Jieli, Bi, Yufang, Wang, Weiqing, Ning, Guang, Zhang, Qiao, and Shi, Lixin

Abstract

Additional file 1: Table S1. Association of diabetes, elevated fasting glucose, elevated OGTT-2h glucose, and elevated HbA1c with non-fatal CVD events and CVD mortality among current, former, and never smokers. 126,181 participants were included in the analysis. The numbers of missing values are 120 for fasting glucose, 683 for OGTT-2h glucose, and 179 for HbA1c. aAdjusted for age, sex, education attainment (less than high school, high school or further education), family history of diabetes (yes, no), family history of CVD (yes, no), fruits and vegetables intake (

Published
2022
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49. Association of education levels with the risk of hypertension and hypertension control: a nationwide cohort study in Chinese adults

Author

Sun, Kan, primary, Lin, Diaozhu, additional, Li, Mian, additional, Mu, Yiming, additional, Zhao, Jiajun, additional, Liu, Chao, additional, Bi, Yufang, additional, Chen, Lulu, additional, Shi, Lixin, additional, Li, Qiang, additional, Yang, Tao, additional, Wan, Qin, additional, Wu, Shengli, additional, Wang, Guixia, additional, Luo, Zuojie, additional, Qin, Yingfen, additional, Tang, Xulei, additional, Chen, Gang, additional, Huo, Yanan, additional, Gao, Zhengnan, additional, Su, Qing, additional, Ye, Zhen, additional, Hu, Ruying, additional, Wang, Youmin, additional, Qin, Guijun, additional, Deng, Huacong, additional, Yu, Xuefeng, additional, Shen, Feixia, additional, Chen, Li, additional, Wang, Weiqing, additional, Ning, Guang, additional, and Yan, Li, additional

Published
2022
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50. The Impact of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics on Risk of Incident Diabetes: A Nationwide Prospective Cohort Study

Author

Zhao, Zhiyun, primary, Cao, Qiuyu, additional, Lin, Hong, additional, Gao, Zhengnan, additional, Xu, Min, additional, Xu, Yu, additional, Wang, Tiange, additional, Li, Mian, additional, Chen, Yuhong, additional, Wang, Shuangyuan, additional, Zeng, Tianshu, additional, Hu, Ruying, additional, Yu, Xue-Feng, additional, Chen, Gang, additional, Su, Qing, additional, Mu, Yiming, additional, Chen, Lulu, additional, Tang, Xulei, additional, Yan, Li, additional, Qin, Guijun, additional, Wan, Qin, additional, Wang, Guixia, additional, Shen, Feixia, additional, Luo, Zuojie, additional, Qin, Yingfen, additional, Chen, Li, additional, Huo, Yanan, additional, Li, Qiang, additional, Ye, Zhen, additional, Zhang, Yinfei, additional, Liu, Chao, additional, Wang, Youmin, additional, Wu, Shengli, additional, Yang, Tao, additional, Deng, Huacong, additional, Zhao, Jiajun, additional, Shi, Lixin, additional, Ning, Guang, additional, Lu, Jieli, additional, Wang, Weiqing, additional, and bi, yufang, additional

Published
2022
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