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Your search keyword '"Qin, Baifu"' showing total 17 results
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17 results on '"Qin, Baifu"'

2. Targeting VCP potentiates immune checkpoint therapy for colorectal cancer

Author

Wang, Fang, Qi, Qi, Qin, Baifu, Wang, Yiwei, Huang, Youwei, Li, Qing, Shen, Xi, Wang, Xiangyu, Yang, Shangqi, Pan, Guopeng, Chen, Jiahong, Qin, Zixi, Chen, Xueqin, Yang, Yuqing, Zeng, Yuequan, Liu, Jun, Li, Yuqin, Li, Ying, Cheng, Zexiong, Lin, Xi, Xing, Fan, Zhang, Yubo, Wang, Guocai, Li, Kai, Jiang, Zhenyou, and Zhang, Haipeng

Published
2023
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5. CSN6‐SPOP‐HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation

Author

Li, Kai, primary, Zhang, Jiayu, additional, Lyu, Haiwen, additional, Yang, Jinneng, additional, Wei, Wenxia, additional, Wang, Yuzhi, additional, Luo, Haidan, additional, Zhang, Yijing, additional, Jiang, Xin, additional, Yi, Hairong, additional, Wang, Mengan, additional, Zhang, Caiyun, additional, Wu, Kang, additional, Xiao, Lishi, additional, Wen, Weijie, additional, Xu, Hui, additional, Li, Guolin, additional, Wan, Yunle, additional, Yang, Fang, additional, Yang, Runxiang, additional, Fu, Xinhui, additional, Qin, Baifu, additional, Zhou, Zhongguo, additional, Zhang, Haipeng, additional, and Lee, Mong‐Hong, additional

Published
2024
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11. Supplementary Data from CSN6 Mediates Nucleotide Metabolism to Promote Tumor Development and Chemoresistance in Colorectal Cancer

Author

Zou, Shaomin, primary, Qin, Baifu, primary, Yang, Ziqing, primary, Wang, Wencong, primary, Zhang, Jieping, primary, Zhang, Yijing, primary, Meng, Manqi, primary, Feng, Junyan, primary, Xie, Yunling, primary, Fang, Ling, primary, Xiao, Lishi, primary, Zhang, Peng, primary, Meng, Xiangqi, primary, Choi, Hyun Ho, primary, Wen, Weijie, primary, Pan, Qihao, primary, Ghesquière, Bart, primary, Lan, Ping, primary, Lee, Mong-Hong, primary, and Fang, Lekun, primary

Published
2023
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12. CSN6 Mediates Nucleotide Metabolism to Promote Tumor Development and Chemoresistance in Colorectal Cancer

Author

Zou, Shaomin, primary, Qin, Baifu, additional, Yang, Ziqing, additional, Wang, Wencong, additional, Zhang, Jieping, additional, Zhang, Yijing, additional, Meng, Manqi, additional, Feng, Junyan, additional, Xie, Yunling, additional, Fang, Ling, additional, Xiao, Lishi, additional, Zhang, Peng, additional, Meng, Xiangqi, additional, Choi, Hyun Ho, additional, Wen, Weijie, additional, Pan, Qihao, additional, Ghesquière, Bart, additional, Lan, Ping, additional, Lee, Mong-Hong, additional, and Fang, Lekun, additional

Published
2022
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15. EGF Relays Signals to COP1 and Facilitates FOXO4 Degradation to Promote Tumorigenesis

Author

Choi, Hyun Ho, primary, Zou, Shaomin, additional, Wu, Jian‐lin, additional, Wang, Huashe, additional, Phan, Liem, additional, Li, Kai, additional, Zhang, Peng, additional, Chen, Daici, additional, Liu, Qingxin, additional, Qin, Baifu, additional, Nguyen, Thu Anh Thai, additional, Yeung, Sai‐Ching J., additional, Fang, Lekun, additional, and Lee, Mong‐Hong, additional

Published
2020
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16. ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer

Author

Li, Kai, primary, Wu, Jian-lin, additional, Qin, Baifu, additional, Fan, Zongmin, additional, Tang, Qin, additional, Lu, Weisi, additional, Zhang, Haipeng, additional, Xing, Fan, additional, Meng, Manqi, additional, Zou, Shaomin, additional, Wei, Wenxia, additional, Chen, Honglei, additional, Cai, Jian, additional, Wang, Huaiming, additional, Zhang, Hui, additional, Cai, Jiayue, additional, Fang, Ling, additional, Bian, Xiqing, additional, Chen, Chuangqi, additional, Lan, Ping, additional, Ghesquière, Bart, additional, Fang, Lekun, additional, and Lee, Mong-Hong, additional

Published
2019
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17. CSN6 Mediates Nucleotide Metabolism to Promote Tumor Development and Chemoresistance in Colorectal Cancer.

Author

Zou S, Qin B, Yang Z, Wang W, Zhang J, Zhang Y, Meng M, Feng J, Xie Y, Fang L, Xiao L, Zhang P, Meng X, Choi HH, Wen W, Pan Q, Ghesquière B, Lan P, Lee MH, and Fang L

Subjects
Humans, COP9 Signalosome Complex genetics, COP9 Signalosome Complex metabolism, Pyrimidines, Nucleotides, DEAD-box RNA Helicases, Drug Resistance, Neoplasm, Colorectal Neoplasms drug therapy, Colorectal Neoplasms genetics
Abstract

Metabolic reprogramming can contribute to colorectal cancer progression and therapy resistance. Identification of key regulators of colorectal cancer metabolism could provide new approaches to improve treatment and reduce recurrence. Here, we demonstrate a critical role for the COP9 signalosome subunit CSN6 in rewiring nucleotide metabolism in colorectal cancer. Transcriptomic analysis of colorectal cancer patient samples revealed a correlation between CSN6 expression and purine and pyrimidine metabolism. A colitis-associated colorectal cancer model established that Csn6 intestinal conditional deletion decreased tumor development and altered nucleotide metabolism. CSN6 knockdown increased the chemosensitivity of colorectal cancer cells in vitro and in vivo, which could be partially reversed with nucleoside supplementation. Isotope metabolite tracing showed that CSN6 loss reduced de novo nucleotide synthesis. Mechanistically, CSN6 upregulated purine and pyrimidine biosynthesis by increasing expression of PHGDH, a key enzyme in the serine synthesis pathway. CSN6 inhibited β-Trcp-mediated DDX5 polyubiquitination and degradation, which in turn promoted DDX5-mediated PHGDH mRNA stabilization, leading to metabolic reprogramming and colorectal cancer progression. Butyrate treatment decreased CSN6 expression and improved chemotherapy efficacy. These findings unravel the oncogenic role of CSN6 in regulating nucleotide metabolism and chemosensitivity in colorectal cancer., Significance: CSN6 deficiency inhibits colorectal cancer development and chemoresistance by downregulating PHGDH to block nucleotide biosynthesis, providing potential therapeutic targets to improve colorectal cancer treatment., (©2022 American Association for Cancer Research.)

Published
2023
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