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Background: Traditionally, depression phenotypes have been defined based on interindividual differences that distinguish between subgroups of individuals expressing distinct depressive symptoms often from cross-sectional data. Alternatively, depression phenotypes can be defined based on intraindividual differences, differentiating between transitory states of distinct symptoms profiles that a person transitions into or out of over time. Such within-person phenotypic states are less examined, despite their potential significance for understanding and treating depression. Methods: The current study used intensive longitudinal data of youths (N = 120) at risk for depression. Clinical interviews (at baseline, 4, 10, 16, and 22 months) yielded 90 weekly assessments. We applied a multilevel hidden Markov model to identify intraindividual phenotypes of weekly depressive symptoms for at-risk youth. Results: Three intraindividual phenotypes emerged: a low-depression state, an elevated-depression state, and a cognitive-physical-symptom state. Youth had a high probability of remaining in the same state over time. Furthermore, probabilities of transitioning from one state to another did not differ by age or ethnoracial minority status; girls were more likely than boys to transition from a low-depression state to either the elevated-depression state or the cognitive-physical symptom state. Finally, these intraindividual phenotypes and their dynamics were associated with comorbid externalizing symptoms. Conclusion: Identifying these states as well as the transitions between them characterizes how symptoms of depression change over time and provide potential directions for intervention efforts

Comorbidity of disordered eating (DE) behaviors and nonsuicidal self-injury (NSSI) is linked to increased functional impairment. The present study identified subtypes of DE and NSSI comorbidity in a non-Western, low- and middle-income country where there has been particularly little research in this area.Latent profile analyses (LPA) were conducted to identify patterns of subgroup comorbidity in self-reported DE behaviors and NSSI behaviors, in a sample of Vietnamese high-school students (N = 1451, 51% female). Parallel-process LPA was used to predict NSSI subgroup membership from DE subgroup membership.A seven-class LPA model was identified for DE: (1) Low frequencies of all DE behaviors; (2) Frequent levels of all DE behaviors; (3) Frequent fasting and purging behaviors; (4) Frequent binge eating only; (5) Moderate binge eating; (6) Moderate fasting and purging behaviors; (7) Exercise and fasting. A two-class (high versus low) model was identified for NSSI. Odds of membership in the high-NSSI class were significantly increased for all DE classes except the class characterized by moderate binge eating. Odds of belonging to the high-NSSI class were highest for those in DE classes involving purging behaviors. Males predominated in classes characterized by high behavior dysregulation.DE and NSSI represent important clinical concerns among Vietnamese youth in urban contexts, and males may show particular vulnerability for certain risk behaviors. The association of classes of DE behaviors to NSSI was particularly strong for classes that involved purging, highlighting the importance of this specific behavior for understanding comorbidity of DE and NSSI.Disordered eating and nonsuicidal self-injury (NSSI; hurting oneself without intending to die) commonly co-occur. There has been less research on disordered eating and NSSI among individuals from non-Western or low/middle-income countries. We examined patterns of these behaviors in a school-based sample of Vietnamese adolescents. We found that patterns of disordered eating distinguished by purging showed particular links to NSSI, which could have implications for screening and treatment.

Objectives. To determine whether intersectional stigma is longitudinally associated with biopsychosocial outcomes. Methods. We measured experienced intersectional stigma (EIS; ≥ 2 identity-related attributions) among sexual minority men (SMM) in the United States participating in the Multicenter AIDS Cohort Study. We assessed longitudinal associations between EIS (2008‒2009) and concurrent and future hypertension, diabetes, dyslipidemia, antiretroviral therapy adherence, HIV viremia, health care underutilization, and depression symptoms (2008‒2019). We conducted causal mediation to assess the contribution of intersectional stigma to the relationship between self-identified Black race and persistently uncontrolled outcomes. Results. The mean age (n = 1806) was 51.8 years (range = 22–84 years). Of participants, 23.1% self-identified as Black; 48.3% were living with HIV. Participants reporting EIS (30.8%) had higher odds of hypertension, dyslipidemia, diabetes, depression symptoms, health care underutilization, and suboptimal antiretroviral therapy adherence compared with participants who did not report EIS. EIS mediated the relationship between self-identified Black race and uncontrolled outcomes. Conclusions. Our findings demonstrate that EIS is a durable driver of biopsychosocial health outcomes over the life course. Public Health Implications. There is a critical need for interventions to reduce intersectional stigma, help SMM cope with intersectional stigma, and enact policies protecting minoritized people from discriminatory acts. (Am J Public Health. 2022;112(S4):S452–S462. https://doi.org/10.2105/AJPH.2022.306735 )

A suitable additive for fish sperm storage in vitro is necessary for artificial reproduction. In this study, we evaluated the effects of different concentrations (100, 200, 400, and 800 µmol/L) of metformin (Met) on Schizthorax prenanti and Onychostoma macrolepis sperm under storage in vitro for 72 h. Compared with the control group, 400 µmol/L Met was more effective at improving the quality and fertilization capacity of Schizothorax prenanti sperm by increasing the adenosine triphosphate (ATP) content within the sperm. Further study found that metformin stabilized the ATP level by enhancing the glucose uptake in Schizothorax prenanti sperm, and this effect might be associated with the activation of AMP-activated protein kinase (AMPK) in sperm. In this study, we also found that the glucose could be absorbed by the sperm of Schizothorax prenanti, which was mainly accumulated in the midpiece of Schizothorax prenanti sperm, where mitochondria were located. In addition, Compound C(CC) significantly inhibited the beneficial effects of Met on the quality and glucose uptake capacity of Schizothorax prenanti sperm by inhibiting AMPK phosphorylation. These results revealed that AMPK played an important role in vitro sperm storage, and Met maintained ATP content, and increased the storage time of Schizothorax prenanti sperm in vitro for 72 h, possibly due to Met enhanced glucose uptake capacity of sperm by activating AMPK. Similarly, the beneficial effects of Met on Schizothorax prenanti sperm were also found in O. macrolepis sperm, suggesting that Met may hold great promise for the practice of storing fish in vitro.

Peer reviewed: True, Acknowledgements: We thank Dr Lifu Deng and Dr. Tianzhu Xiong for valuable advice on imaging data processing., BACKGROUND: Though deep brain stimulation (DBS) shows increasing potential in treatment-resistant depression (TRD), the underlying neural mechanisms remain unclear. Here, we investigated functional and structural connectivities related to and predictive of clinical effectiveness of DBS at ventral capsule/ventral striatum region for TRD. METHODS: Stimulation effects of 71 stimulation settings in 10 TRD patients were assessed. The electric fields were estimated and combined with normative functional and structural connectomes to identify connections as well as fibre tracts beneficial for outcome. We calculated stimulation-dependent optimal connectivity and constructed models to predict outcome. Leave-one-out cross-validation was used to validate the prediction value. RESULTS: Successful prediction of antidepressant effectiveness in out-of-sample patients was achieved by the optimal connectivity profiles constructed with both the functional connectivity (R=0.49 at p

Individuals with a higher (vs. lower) tendency to outwardly express anger (i.e., greater anger-out) generally exhibit greater aggression; men (vs. women) also tend to be more aggressive. Although the general aggression model posits that multiple person variables trigger aggression, the combined effects of multiple person variables are poorly understood. Thus, the aim of this study was to examine the nature of the relation between gender, anger-out, and reactive aggression. In particular, we were interested in whether the effects of anger-out and gender are additive or multiplicative. Specifically, we tested whether men exhibit higher levels of aggression than women at a consistent ratio across all levels of anger-out (i.e., the multiplicative model) or at a fixed amount depending on the level of anger-out (i.e., the additive interaction model). To this end, undergraduate participants (N = 203) completed a task in which they were falsely instructed that their objective was to respond more quickly than a same-sex opponent. They were told that whoever responded more quickly would administer a white noise burst to the opponent and choose its intensity, which served as our measure of aggression. Compared to an additive interaction model, the multiplicative model exhibited a better fit. Specifically, men displayed proportionately more aggression than women with the same level of anger-out. Research on and treatment for aggression should consider the multiplicative effects of factors related to aggression.

Background Research among adults has rarely differentiated between tonic irritability (i.e., irritable mood) and phasic irritability (i.e., aggressive outbursts) with respect to multiple dimensions of depression. The current study explored both tonic and phasic irritability in relation to depression severity, depression chronicity, age of depression onset, individual depressive symptom, and depression subtypes. Methods The study included participants (N = 5692) from the National Comorbidity Survey – Replication (NCS-R) part two. The NCS-R used lay-administered, fully standardized diagnostic interviews. The current study implemented linear models, generalized linear models, Cox proportional hazard model, and latent class regression. Results Both types of irritability were significantly associated with greater risk for MDD diagnosis, as well as risk for having at least one depressive symptom, early MDE onset, and MDE chronicity. Both phasic and tonic irritability were associated with greater odds of specific depressive symptoms and were differentially related to distinct depressive symptom constellations. Phasic irritability related only to severe depression. Lastly, both phasic and tonic irritability was associated with suicidal ideation, but only phasic irritability was associated with a suicide plan and attempt, above and beyond depression subtypes. Conclusions Both phasic and tonic irritability differentially related to almost all aspects of depression in adults. Specifically, tonic irritability showed overall stronger associations with various depressive features, whereas phasic irritability marked higher depressive severity.

Although hopelessness has been linked to depression for centuries, the diagnostic criteria for depression are inconsistent with regard to the status of hopelessness. Most research on hopelessness and depression has focused on adults. The current study examined this relation in children and adolescents. Integrative data analyses with a pooled sample (N = 2466) showed that clinical levels of hopelessness multiplied the odds of having a clinical diagnosis of depression 10-fold. Conversely, not having clinical levels of hopelessness multiplied the odds of endorsing no clinical level of depressive symptoms 28-fold. Moreover, results differed by levels of depression: (a) among youths with clinical levels of depression, hopelessness was associated with six depressive symptoms; (b) among youths without clinical levels of depression, hopelessness was associated with nine depressive symptoms. We found that hopelessness helps to explain the heterogeneity of depressive presentations. Our finding supports the consideration of hopelessness in the diagnosis (if not treatment and prevention) of depression in children and adolescents. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Adolescent self-esteem and depression are influenced by important psychosocial factors such as parental relationships, yet it is unclear how these within-person relations present over time. The current study investigates the longitudinal relations between self-esteem, depressed affect, and parent-adolescent closeness during middle adolescence. Adolescents (n = 562; mean age = 14.73, SD = 0.82; 52% female; 72% White, 28% Racial Minority) were surveyed annually over four years (1988-1991). A random-intercept cross-lagged panel model was applied to disaggregate between- and within-person associations. Consistent with the scar model, adolescents experiencing heightened depressed affect were likely to have lower self-esteem. Furthermore, perceived mother-adolescent, but not father-adolescent, closeness positively predicted adolescent self-esteem. The results highlight the importance of considering interpersonal relationships and age in developmental models of self-esteem and depression.

Mood disturbances have historically remained a core criterion in diagnosing major depressive episode. DSMs have illustrated this criterion with depressed, hopeless, discouraged, cheerless, and irritable mood, suggesting interchangeability. Extant research has examined individual forms of mood disturbance to depression severity. Less examined is the heterogeneity in mood disturbances and its implication to their association to depression presentations and outcomes.The current study used a nationally representative sample of U.S. adults with unipolar major depressive disorder to study the association between specific forms of mood disturbances to depression severity, chronicity, or symptoms, above and beyond other forms, as well as their relations to functional impairment, suicidal outcomes, and psychiatric comorbidity via generalized linear models.Cheerless and hopeless mood were associated with depression severity. Hopeless and irritable mood were associated with depression chronicity. Different forms of mood disturbance showed differential relations to depressive symptoms. Cheerless, hopeless, and irritable mood were associated with depression-specific functional interference, incremental to depression severity. Cheerless, hopeless, and discouraged mood were associated with passive suicidal ideation. Hopeless mood was associated with active suicidal ideation. Hopeless and irritable mood were associated with both suicide plan and suicide attempt. Different forms of mood disturbance demonstrated differential associations to comorbid psychiatric conditions.The relations between different forms of mood disturbances and various aspects of depression are nuanced. Theoretically, these relations highlight the potential utility in acknowledging the complexity and heterogeneity in mood disturbances. Clinically, our results suggest potential utility in routinely monitoring mood disturbances.

Suicidal ideation (SI) and attempts (SA) are prevalent in late adolescence and emerging adulthood. Prior research has identified perceived support as a correlate of SI and SA. Less is known, though, about the role of perceived support in differentiating among suicidal outcomes and between the incremental escalation of suicidal outcomes from SI to SA to serious suicide attempts (SSA).Using ordinal regression, we used Wave 1 and 2 data from the National Longitudinal Study of Adolescent to Adult Health (N = 4500; 53% female; MCross-sectional results indicated that youths with higher perceived support were less likely to have suicidal ideation. Longitudinal results showed that youths with higher perceived support at Wave 1 were less likely to have suicidal ideation or serious suicide attempts at Wave 2. Transitional model results revealed that higher perceived support at Wave 1 was negatively associated with escalation in suicidal outcomes from Wave 1 to 2.We discuss findings in the context of theories of suicide and discuss implications for suicide risk identification, intervention, and prevention efforts in late adolescence and emerging adulthood.

In randomized pretest-posttest experimental designs, experimental treatments are commonly compared through an additive difference. The assumed additive effects of experimental treatments, in randomized pretest-posttest design, also correspond to additive differences between pre- and posttreatment measures. However, it is possible that experimental treatments differ in ratios and the treatment effects are multiplicative. Logarithmic-transformed ANOVA (LANOVA) and logarithmic-transformed ANCOVA (LANCOVA)-reparameterizations of log-log regression models-are proposed to test multiplicative effects given randomized pretest-posttest experimental designs. In addition, a new effect size measure is proposed for treatment effects that are multiplicative instead of additive. Model selection strategy, sample size planning, and power calculation for the proposed methods are also provided. Simulation studies were conducted to compare the Type I error rates and power of proposed methods to those of symmetrized change analysis, ANOVA, ANCOVA, gain score analysis, and ANCOVA with logarithmic-transformed dependent variable given population effect of both additive and multiplicative nature. An empirical data analysis follows to show the interpretational difference between multiplicative and additive effects. While logarithmic transformations are most often recommended to address skewness, our article shows how a log transformation can be used to reconceptualize the fundamental nature of the treatment effect. Finally, recommendations, limitations, and future directions are discussed. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

A fascinating feature of photo-sensitive hydrogels with dissolved salts is their light-adjustable ability to conduct electricity. Recently, N-isopropylacrylamide (NIPAAm) polymer electrolytes have been employed to mitigate the thermal runaway of lithium-ion batteries due to the temperature-induced phase transition. Based on this emerging application, we propose an idea in this paper that spirobenzopyran-modified NIPAAm (pSpNIPAAm) hydrogels might be used as smart electrolytes to address the safety issue of renewable energy storage devices through the light-modulated hydration microenvironment. For the design of photo-sensitive hydrogel electrolytes, a multiphysics model is developed to analyze the response characteristic of a pSpNIPAAm hydrogel in saline solution in terms of Hofmeister series. Using this model, the light-to-electrochemical response mechanism is elucidated where the light intensity manipulates the content of each isomer via the photochemical reaction rate, leading to changes in ionic conductivity and electrical potential gradient that are dominated by the hydration state and fixed-charge density within the hydrogel, respectively. After model validation with the help of published experiments, numerical simulation was used to examine the electrochemical and mechanical response of photo-sensitive hydrogels subjected to several external stimuli, such as temperature, ionic strength, and light intensity. It is demonstrated by computational results that the Hofmeister series, charge offset, and buffer pH play an important role in the response characteristic of a hydrogel. The swelling stretch and ionic conductivity collapsed at a temperature that is reduced by 2–5 °C upon changing the salt species from NaCl to Na2SO4 under equivalent light intensity. For photo-stimulated electrical responses, a large charge offset ratio results in significant changes and the buffer pH functions as a polarity switch. These findings provide fundamental cues for the design and optimization of a smart energy storage system based on photo-sensitive hydrogel electrolytes.

Stress and sleep problems are significantly correlated in adolescents. Few longitudinal studies, however, have evaluated possible correlates and predictors of sleep problems at multiple points across adolescence. The current study examined the relation between stress and sleep problems across four years in a sample of adolescents who varied in risk for psychopathology. Participants included 223 adolescents (55% female) and 223 mothers (77% with a history of a mood disorder during their child's life). Youth were evaluated in grade 7 (M = 12.69 years, SD = 0.61) and again in grades 8, 9, and 11. Sleep problems were assessed as part of a clinical interview, and weekly stressful events were measured with the Life Events Interview for Adolescents. Multi-group latent growth curve analyses were conducted. Among youth whose mothers had a history of depression (high-risk), sleep problems significantly increased over time (p .001). Second, among high-risk youth, at each time point, higher stress levels during the prior three months significantly predicted higher levels of sleep problems (p .001). Finally, across the entire sample, at each time point a greater level of sleep problems predicted higher stress ratings a year later (p ≤ .001). Thus, stress was a significant predictor of sleep problems across multiple years of adolescence, particularly among offspring of mothers with a history of depression. Results highlight targets for preventive interventions for sleep problems in youth.

Hypothesis The performance of a polymeric core–shell microreactor depends critically on (i) mass transfer, (ii) catalyzed chemical reaction, and (iii) deactivation within the nonuniform core–shell microstructure environment. As such, these three basic working principles control the active catalytic phase density in the reactor. Theory We present a high-fidelity, image-based nonequilibrium computational model to quantify and visualize the mass transport as well as the deactivation process of a core–shell polymeric microreactor. In stark contrast with other published works, our microstructure-based computer simulation can provide a single-particle visualization with a micrometer spatial accuracy. Findings We show how the interplay of kinetics and thermodynamics controls the product-induced deactivation process. The model predicts and visualizes the non-trivial, spatially resolved active catalyst phase patterns within a core–shell system. Moreover, we also show how the microstructure influences the formation of foulant within a core–shell structure; that is, begins from the core and grows radially onto the shell section. Our results suggest that the deactivation process is highly governed by the porosity/microstructure of the microreactor as well as the affinity of the products towards the solid phase of the reactor.

Although theoretical models suggest that an attentional bias for threat contributes to the development of post-traumatic stress disorder (PTSD) symptoms, this bias has not been consistently observed in the literature. In the present study, trauma exposed veterans (N = 114) performed an emotional attentional blink task in which task-irrelevant combat-related, disgust, positive, or neutral distractor images appeared 200 ms, 400 ms, 600 ms, or 800 ms (i.e., lag 2, 4, 6, and 8, respectively) before the target. Relative to neutral distractors, impaired target detection was observed following combat distractors and disgust distractors, but not positive distractors. However, veterans were less accurate following disgust distractors compared to combat distractors. As predicted, combat distractors and disgust distractors were also associated with a stronger linear increase in trial accuracy reflecting task improvement with increasing lag before the target. However, the linear trend in trial accuracy for combat distractors and disgust distractors did not significantly differ from each other. Contrary to predictions, trauma specific (i.e., PTSD symptoms and diagnosis) and nonspecific processes (i.e., attentional control) were unrelated to trial accuracy. These data suggest that while initial attentional capture by cues of war is observed among trauma exposed veterans independent of individual differences in trauma specific and nonspecific symptoms, this attentional capture is less robust compared to attentional capture by disgust-eliciting stimuli. The implications of these findings for the theorized role of attentional biases for threat in the development and maintenance of PTSD are discussed.

Introduction: Little is known about the epidemiology of aggressive outbursts, including physical assault, property destruction, and verbal aggression, among adults with unipolar major depressive disorder (MDD). Methods: We examined the prevalence and correlates of aggressive outbursts among adults with primary MDD (N=2539) from the Collaborative Psychiatric Epidemiological Study (N=20013) using generalized linear models. Results: The prevalence estimate of any aggressive outbursts was 58.7% among adults with MDD. MDD was associated with aggressive outbursts independent of other psychiatric diagnoses. The prevalence of aggressive outbursts differed significantly by age, race/ethnicity, sex, education, marital status, and employment status, and psychiatric diagnoses. Aggressive outbursts were associated with greater severity and earlier age of onset for MDD. Positive associations were also found between the frequency of aggressive outbursts and depressive symptoms including weight/appetite change, fatigue, recurrent thoughts of death. Moreover, aggressive outbursts significantly multiplied the odds of experiencing higher levels of functional impairment, suicidal ideation, suicide plan, and suicide attempt. Conclusion: Aggressive outbursts are much more common than previously recognized among adults with MDD. The significant association of aggressive outbursts with MDD characteristics, increased functional impairment, and suicidal thoughts and behaviors make them an important target for assessment and treatment for adults with MDD.

Research on the relations between irritability and suicidality among adults has rarely compared or differentiated between tonic versus phasic irritability. The current cross-sectional study investigated the role of both tonic and phasic irritability in relation to lifetime suicidal ideation, plans, and attempts. The study included adult participants who completed the suicidality module from the National Comorbidity Survey – Replication (NCS-R) (N = 7683 for suicidal ideation and N = 1223 for suicidal plan and attempt). The NCS-R used lay-administered, standardized diagnostic interviews. Phasic and tonic irritability were assessed with individual screener items from the World Health Organization Composite International Diagnostic Interviews (CIDI). The current study used logistic regression, weighted Cox proportional hazard model, and multinomial logit regression, adjusting for sex, race/ethnicity, age, education, and marital status. Both types of irritability were included simultaneously in the models. Results indicated that both types of irritability were significantly associated with increased odds of suicidal ideation (phasic: Odds Ratio 2.72 [2.35,3.14]); tonic: OR 2.34 [2.04,2.68]), age of first-time suicidal ideation (phasic: Adjusted Hazard Ratio 2.87 [2.27, 3.63]; tonic: AHR 2.12 [1.76,2.54]), and suicide attempt (phasic: OR 1.53 [1.13,2.07]); tonic: OR 1.44 [1.11,1.89]). Only tonic but not phasic irritability was associated with suicide plans (OR 1.39 [1.08,1.79]). When suicide attempts were divided into those that were impulsive versus planned and compared them to no suicide attempt, both types of irritability were associated planned attempts, (phasic: OR 1.53 [1.13,2.07]); tonic: OR 1.44 [1.11,1.89]) but only phasic irritability was related to impulsive attempts (OR 1.70 [1.10,2.64]). Phasic and tonic irritability show differential relations to and can serve as differential markers for suicide-related outcomes in adults.

Children are opportunistic word learners, making passive use of nearly any available cue to link labels and referents. However, children may also actively drive their word learning by inquiring about unknown labels. Until recently, research has largely overlooked active word learning mechanisms. In the current study, two experiments investigated the emergence of preschoolers' ability to tailor their questions about words and definitions to maximize information gains. Experiment 1 tested whether 3- and 5-year-olds' frequency of questionasking differed for known and unknown verbs in a referential communication task. Results revealed that 3- and 5-year-olds (N = 36) asked more questions about unknown verbs (M = 3.86) than about known verbs (M = 0.22, p .001), but this tendency was greater for 5-year-olds (M = 6.11) than for 3-year-olds (M = 1.35, p .001), suggesting a developmental difference in information-seeking proficiency. Experiment 2 tested whether 3- and 5-year-olds' frequency of question asking about unknown verbs differed when words were embedded in definitions of high- and low-informative quality. Results demonstrated that 3- and 5-year-olds (N = 42) asked questions about unknown verbs more when provided with uninformative definitions (M = 0.86) compared with informative definitions (M = 0.05, p = .028), suggesting a sensitivity to definition quality that drives preschoolers' information search for word meanings. These findings offer insight into children's information seeking during exposure to new words. Results advance the characterization of children's active verbal information seeking in shaping their word learning.

Background Theories connecting depression to emotional reactivity (ER) or cognitive reactivity (CR) have not clearly indicated whether ER and CR are between-person or within-person constructs. Most empirical tests of these theories have focused on either between- or within-person operationalizations of these constructs, but not both. Between- and within-person studies address qualitatively different questions and often generate very different results. Consequently, the goals of the current study were to examine the relation of depressive symptoms to both between- and within-person operationalizations of both ER and CR. Methods Participants were 160 undergraduate students who completed daily diary measures (assessing stress, negative emotions, and negative cognitions) and measures of depressive symptoms. Multilevel modeling (MLM) enabled examination of depressive symptoms to the within- and between-person components of ER and CR. Results: Depressive symptoms were positively related to within-person ER and CR but not to between-person operationalizations of ER and CR. Limitations The sample only included college students and only assessed depressive symptoms, not clinical diagnoses of major depression. Conclusions Important implications emerge for theory, practice, and future research. We recommend distinguishing between-person from within-person dimensions of ER and CR in future research.

Introduction Little is known about the epidemiology of aggressive outbursts, including physical assault, property destruction, and verbal aggression, among adults with unipolar Major Depressive Disorder (MDD). Methods We examined the prevalence and correlates of aggressive outbursts among adults with primary MDD (N = 2539) from the Collaborative Psychiatric Epidemiological Surveys (N = 20,013) using generalized linear models. Results The prevalence estimate of any aggressive outbursts was 58.7% among adults with MDD. MDD was associated with aggressive outbursts independent of other psychiatric diagnoses. The prevalence of aggressive outbursts differed significantly by age, race/ethnicity, sex, education, marital status, and employment status, and psychiatric diagnoses. Aggressive outbursts were associated with greater severity and earlier age of onset for MDD. Positive associations were also found between the frequency of aggressive outbursts and depressive symptoms including weight/appetite change, fatigue, recurrent thoughts of death. Moreover, aggressive outbursts significantly multiplied the odds of experiencing more severe functional impairment, suicidal ideation, suicide plan, and suicide attempt. Conclusion Aggressive outbursts are much more common than previously recognized among adults with MDD. The significant association of aggressive outbursts with MDD characteristics, increased functional impairment, and suicidal thoughts and behaviors make them an important target for assessment and treatment for adults with MDD.

One of the existing approaches to time series classification exploits the time profiles using the original data with synchronization instead of model-implied data. Synchronization aligns inter-individual data from different time points to account for potential phase offsets and nonstationarity in the data. Such synchronization has been applied in psychology: For example, coordinated motion between two individuals exchanging information was used as a predictor and outcome of psychological processes. Synchronization also affords better classification outcomes, as discussed in the data mining community, through aligning the data to reveal the maximally shared profile underlying two compared data sequences. For inter-individual comparison of univariate time series data, existing similarity indices include Euclidean distances and squared correlations. For synchronization, we introduce dynamic time warping and window-crossed lagging. The current study compares the Euclidean distance and the squared correlation before and after synchronization using window-crossed lagging and dynamic time warping in applications to one-nearest-neighbor classification tasks. Discussion, limitations, and future directions are provided.

Ceiling and floor effects are often observed in social and behavioral science. The current study examines ceiling/floor effects in the context of the t-test and ANOVA, two frequently used statistical methods in experimental studies. Our literature review indicated that most researchers treated ceiling or floor data as if these data were true values, and that some researchers used statistical methods such as discarding ceiling or floor data in conducting the t-test and ANOVA. The current study evaluates the performance of these conventional methods for t-test and ANOVA with ceiling or floor data. Our evaluation also includes censored regression with regard to its capacity for handling ceiling/floor data. Furthermore, we propose an easy-to-use method that handles ceiling or floor data in t-tests and ANOVA by using properties of truncated normal distributions. Simulation studies were conducted to compare the performance of the methods in handling ceiling or floor data for t-test and ANOVA. Overall, the proposed method showed greater accuracy in effect size estimation and better-controlled Type I error rates over other evaluated methods. We developed an easy-to-use software package and web applications to help researchers implement the proposed method. Recommendations and future directions are discussed.