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6 results on '"Qimao Huang"'

1. Bis[N-(2-furylmethyl)ethane-1,2-diamine]bis(perchlorato)copper(II)

Author

Wei Xiao, Shi-Rong Li, Hong Zhou, Zhi-Quan Pan, and Qimao Huang

Subjects
Crystallography, QD901-999
Abstract

In the title complex, [Cu(ClO4)2(C7H12N2O)2], the Cu(II) ion lies on a crystallographic inversion centre. The coordination sphere around Cu(II) ion can be described as tetragonally distorted octahedral with two perchlorate O atoms occupying the apical positions and four N atoms from two N1-(2-furylmethyl)ethane-1,2-diamine ligands in the basal plane.

Published
2011
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5. Zinc(II) and copper(II) complexes of β-substituted hydroxylporphyrins as tumor photosensitizers

Author

Qimao Huang, Zhangping Chen, Ping Wang, Xiao-Lian Zhang, Zhiquan Pan, and Hansheng Xu

Subjects
Porphyrins, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, chemistry.chemical_element, Antineoplastic Agents, Photodynamic therapy, Zinc, Hydroxylation, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Photosensitizer, Molecular Biology, Cell Proliferation, Photosensitizing Agents, Molecular Structure, Singlet oxygen, Organic Chemistry, Biological activity, Copper, chemistry, Zinc Compounds, Molecular Medicine, DNA, Plasmids, Nuclear chemistry
Abstract

Novel photosensitizers beta-(hydroquinon-2-yl)-5,10,15,20-tetra(4-hydroxylphenyl)porphyrinato zinc(II) (Zn(II)P) and beta-(hydroquinon-2-yl)-5,10,15,20-tetra(4-hydroxylphenyl)porphyrinato copper(II) (Cu(II)P) were synthesized and characterized. Their ability of producing singlet oxygen under irradiation was detected by the measurement of decomposition of 1,3-diphenylisobenzofuran (DPBF). The preliminary biological activity studies show that the Zn(II)P has photo-toxicity on human chronic myelogenous leukemia cell (K562) and could cleave supercoiled DNA (pBR 322 DNA), while the Cu(II)P has inferior biological activity. Results showed Zn(II)P having high anti-tumor activity, which presents a promising photosensitizer for photodynamic therapy.

Published
2006
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