Search

Your search keyword '"Qiaonan Liu"' showing total 7 results
Start Over Author "Qiaonan Liu"
7 results on '"Qiaonan Liu"'

1. Coaxial electrohydrodynamic printing of core–shell microfibrous scaffolds with layer-specific growth factors release for enthesis regeneration

Author

Lang Bai, Meiguang Xu, Zijie Meng, Zhennan Qiu, Jintao Xiu, Baojun Chen, Qian Han, Qiaonan Liu, Pei He, Nuanyang Wen, Jiankang He, Jing Zhang, and Zhanhai Yin

Subjects
coaxial electrohydrodynamic printing, core–shell structures, microfibrous scaffolds, growth factors, enthesis regeneration, Materials of engineering and construction. Mechanics of materials, TA401-492, Industrial engineering. Management engineering, T55.4-60.8, Physics, QC1-999
Abstract

The rotator cuff tear has emerged as a significant global health concern. However, existing therapies fail to fully restore the intricate bone-to-tendon gradients, resulting in compromised biomechanical functionalities of the reconstructed enthesis tissues. Herein, a tri-layered core–shell microfibrous scaffold with layer-specific growth factors (GFs) release is developed using coaxial electrohydrodynamic (EHD) printing for in situ cell recruitment and differentiation to facilitate gradient enthesis tissue repair. Stromal cell-derived factor-1 (SDF-1) is loaded in the shell, while basic fibroblast GF, transforming GF-beta, and bone morphogenetic protein-2 are loaded in the core of the EHD-printed microfibrous scaffolds in a layer-specific manner. Correspondingly, the tri-layered microfibrous scaffolds have a core–shell fiber size of (25.7 ± 5.1) μ m, with a pore size sequentially increasing from (81.5 ± 4.6) μ m to (173.3 ± 6.9) μ m, and to (388.9 ± 6.9 μ m) for the tenogenic, chondrogenic, and osteogenic instructive layers. A rapid release of embedded GFs is observed within the first 2 d, followed by a faster release of SDF-1 and a slightly slower release of differentiation GFs for approximately four weeks. The coaxial EHD-printed microfibrous scaffolds significantly promote stem cell recruitment and direct their differentiation toward tenocyte, chondrocyte, and osteocyte phenotypes in vitro . When implanted in vivo , the tri-layered core–shell microfibrous scaffolds rapidly restored the biomechanical functions and promoted enthesis tissue regeneration with native-like bone-to-tendon gradients. Our findings suggest that the microfibrous scaffolds with layer-specific GFs release may offer a promising clinical solution for enthesis regeneration.

Published
2024
Full Text
View/download PDF

2. Surgical treatment strategy for recurrent parastomal hernia: Experiences from 17 cases

Author

Li Luan, Qiaonan Liu, Changjin Cui, Yugang Cheng, Guangyong Zhang, and Bo Li

Subjects
recurrent parastomal hernia, laparoscopy, parastomal hernia, recurrent, hernia, Surgery, RD1-811
Abstract

PurposeThis study aimed to investigate the surgical treatment strategy of recurrent parastomal hernia (PH) and show its safety, feasibility, and outcomes at a mid-term follow-up.MethodsA total of 17 cases of recurrent PH treated at our hospital between January 2016 and October 2021 were included in this retrospective analysis. Patient characteristics were recorded, and the classification of PH, operative time, intraoperative blood loss, hernia repair techniques, follow-up times, complications, as well as recurrence were compared and analyzed.ResultsAltogether, 17 patients with recurrent PH underwent successful hernia repair via surgical treatment at The First Affiliated Hospital of Shandong First Medical University and Shandong University Qilu Hospital. No recurrence or severe complications were noted during follow-ups (mean 32.8 ± 3.77 [range 3–68] months).ConclusionsFor recurrent PH, selecting a suitable repair approach based on intraperitoneal conditions such as infection, abdominal adhesions, or the length of the bowel loop, can help in achieving better therapeutic results. The lap-redo + Sugarbaker technique is worth recommending when the appropriate conditions are met.

Published
2022
Full Text
View/download PDF

3. Treatment of Chronic Traumatic Diaphragmatic Hernia Based on Laparoscopic Repair: Experiences From 23 Cases

Author

Qiaonan Liu, Li Luan, Guangyong Zhang, and Bo Li

Subjects
laparoscopy, diaphragmatic hernia, laparotomy, thoracotomy, muscle flap, Surgery, RD1-811
Abstract

Background: We aimed to investigate the safety and effectiveness of laparoscopic repair for treating chronic traumatic diaphragmatic hernia (CTDH).Methods: In this retrospective analysis, we included 23 cases with CTDH underwent laparoscopy in our hospital between June 2015 and October 2019 was performed. The patient characteristics were recorded. We compared the diameter of hernia ring, surgery duration, intraoperative bleeding volume, means of repairing, as well as the follow-up data.Results: All the patients underwent laparoscopic diaphragmatic hernia repair, without conversion to laparotomy or thoracotomy. The operation time ranged from 60 min to 200 min (mean, 108.04 ± 42.93 min). The blood loss volume ranged from 10 to 300 ml (mean volume, 63.48 ± 71.69 ml). The postoperative hospital stayed ranged from 5 to 15 days (mean, 6.22 ± 2.11 days). The patients were followed up for 1–50 months (mean, 17.5 ± 10.90 months). No recurrence of diaphragmatic hernia was found.Conclusions: Laparoscopic repair of CTDH is featured by fast recovery, high security, and effectiveness. Reducing the hernia contents and close of the hernia ring are crucial for the surgery that is performed based on the size and location of the diaphragmatic hernia.

Published
2021
Full Text
View/download PDF

6. Laparoscopic hernia repair in patients with peritoneal dialysis

Author

Changjin Cui, Lei Zhang, Li Luan, Qiaonan Liu, Yugang Cheng, and Bo Li

Abstract

Purpose This study aimed to investigate the feasibility, efficacy, and safety of laparoscopic hernia repair in patients experiencing hernia while undergoing peritoneal dialysis. Methods The clinical data of 9 patients undergoing peritoneal dialysis complicated by abdominal hernia admitted for repair from July 15, 2020 to April 18, 2022 were retrospectively analyzed, and the therapeutic effect of the surgical approach was determined. Results From July 15, 2020 to April 18, 2022, 9 patients undergoing peritoneal dialysis experienced an abdominal wall hernia, all of whom underwent laparoscopic hernia repair in the First Affiliated Hospital of Shandong First Medical University. Moreover, 7 patients presented with inguinal hernia, among whom 3 exhibited intraoperative bilateral inguinal hernia, all of whom underwent conventional TAPP surgery. Moreover, 2 cases presented with umbilical hernia, repaired by IPOM. All surgeries were successful without requiring conversion to open surgery. The mean follow-up time was (8.33±7.61) months, and no recurrence or chronic pain was reported. One patient died due to a car accident. Discussion Laparoscopic hernia repair is a feasible and effective intervention for patients undergoing peritoneal dialysis complicated by an abdominal hernia. The advantages of laparoscopic hernia repair over open surgery include simplicity of the surgical approach, accelerated recovery, a reduced incidence of complications, the allowance of simultaneous observation of the contralateral inguinal region intraoperatively, and simultaneous fixation of the dialysis tube as needed. Given these observed advantages, laparoscopic hernia repair should be considered as a safe and effective surgical method for patients undergoing peritoneal dialysis complicated by abdominal hernia.

Published
2022

7. A cohort study of T helper 17 cell-related cytokine levels in tear samples of systemic lupus erythematosus and Sjögren's syndrome patients with dry eye disease

Author

Xiang Peng, Yamei Lu, Jianbo Wei, Tianhui Lin, Qinyan Lu, Qiaonan Liu, and Wei-Jen Ting

Subjects
Cohort Studies, Sjogren's Syndrome, Rheumatology, Immunology, Immunology and Allergy, Cytokines, Humans, Lupus Erythematosus, Systemic, Th17 Cells, Dry Eye Syndromes
Abstract

Sjögren's syndrome (SS) is the most common autoimmune disease with dry eye (DE) syndrome and some systemic lupus erythematosus (SLE) patients are also with DE syndrome. The occurrence of immune-related DE disease is closely related to T helper (Th) 17 cells in SS patients, and SLE patients have abnormal levels of multiple Th17 cell-related cytokines in their blood. However, the degree of expression of these cytokines in blood differs from that in tears. We hypothesised that the occurrence of DE symptoms in SLE and SS patients may be related to Th17 cells.In this study, Th17 cell-related cytokines, including interleukin (IL)-1β, IL-2, IL-4, interferon-γ, IL 6, IL-8, IL-17F, tumour necrosis factor (TNF)-α, IL-21, IL-22, and IL-23 were analysed in tear samples of DE, SLE, and SS patients. Ocular surface examinations for patients with DE symptoms, including tear secretion test (Schirmer I Test, SIT) and tests for ocular surface disease index (OSDI), tear break-up time (BUT), and corneal fluorescein stain (CFS), were performed and compared between the following patient groups: normal healthy people (control group, n=30), patients with simple DE disease (DE group, n=13), SLE patients with DE disease (SLE group, n=17), and SS patients with DE disease (SS group, n=18).The expression of Th17 cell-related cytokines in each tear sample was analysed using Luminex assay. The SIT and BUT scores of the SLE group were lower than those of the control (p0.001) and DE (p0.05) groups. However, SIT, BUT, CFS, and OSDI scores were not significantly different between SLE and SS patients. TNF-α, IL-6, IL-8, and IL-21 levels in tear samples were higher in DE, SLE, and SS patients (p0.05) than in control individuals. IL-2 and IL-4 levels in tear samples of SLE patients were higher than DE (p0.001) but lower than the control (p0.001) group patients. IL-23 levels in tear samples of DE, SLE, and SS patients were all lower than those in the control group (p0.001). SIT, BUT, CFS, and OSDI results showed that the DE symptoms of SLE and SS patients were more severe than those of the DE group.It is known that cytokine expression levels in tears are different from those in blood. Abnormal regulation of the Th17 cell pathway may be related to the occurrence of DE disease in SLE and SS patients, and Th17 cell-related cytokines, such as IL-8 and IL-21, may be potential therapeutic targets for treating SLE or SS DE disease.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results