2,564 results on '"Qian, Zhu"'
Search Results
2. DNASimCLR: a contrastive learning-based deep learning approach for gene sequence data classification
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Minghao Yang, Zehua Wang, Zizhuo Yan, Wenxiang Wang, Qian Zhu, and Changlong Jin
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Biological sequence data ,Representation learning ,Contrastive learning ,SimCLR ,Convolutional neural networks ,Sequence classification ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background The rapid advancements in deep neural network models have significantly enhanced the ability to extract features from microbial sequence data, which is critical for addressing biological challenges. However, the scarcity and complexity of labeled microbial data pose substantial difficulties for supervised learning approaches. To address these issues, we propose DNASimCLR, an unsupervised framework designed for efficient gene sequence data feature extraction. Results DNASimCLR leverages convolutional neural networks and the SimCLR framework, based on contrastive learning, to extract intricate features from diverse microbial gene sequences. Pre-training was conducted on two classic large scale unlabelled datasets encompassing metagenomes and viral gene sequences. Subsequent classification tasks were performed by fine-tuning the pretrained model using the previously acquired model. Our experiments demonstrate that DNASimCLR is at least comparable to state-of-the-art techniques for gene sequence classification. For convolutional neural network-based approaches, DNASimCLR surpasses the latest existing methods, clearly establishing its superiority over the state-of-the-art CNN-based feature extraction techniques. Furthermore, the model exhibits superior performance across diverse tasks in analyzing biological sequence data, showcasing its robust adaptability. Conclusions DNASimCLR represents a robust and database-agnostic solution for gene sequence classification. Its versatility allows it to perform well in scenarios involving novel or previously unseen gene sequences, making it a valuable tool for diverse applications in genomics.
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- 2024
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3. Clinical strategy study on prenatal screening and diagnostic model for Down syndrome
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Wei Luo, Sha Liu, Bin He, Daiwen Han, Lixing Yuan, Kai Zhao, Jun Tang, Ling Pang, Fene Zou, Jianlong Liu, Hongqian Liu, Ting Bai, Xiaosha Jing, Tianyu Xia, Cechuan Deng, Yunyun Liu, Jing Cheng, Xiang Wei, Lingling Xing, Yuan Luo, Quanfang Zhou, Qian Zhu, and Shanling Liu
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Down syndrome ,Serological screening ,Non-invasive prenatal screening ,Prenatal diagnosis ,Health economics ,Medicine ,Science - Abstract
Abstract Exploring efficient and easily implementable prenatal screening strategies aims at birth defect prevention and control. However, there have been limited economic evaluations of non-invasive prenatal screening (NIPS) strategies in China. Furthermore, these studies were predominantly confined to local or geographically proximate provinces and lacked universality and representativeness. This study assesses the health economics of current prenatal screening strategies and NIPS as first-line screening programs, analyzing their efficacy to determine an optimal strategy. From the perspective of health economics, cost-effectiveness, cost-benefit, and single-factor sensitivity were conducted for five different screening strategies using a decision tree model. Among pregnant women aged
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- 2024
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4. Schisandrin B alleviates testicular inflammation and Sertoli cell apoptosis via AR-JNK pathway
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Bo-Yang Zhang, Rui Yang, Wen-Qian Zhu, Chun-Ling Zhu, Lan-Xin Chen, Yan-Sen Zhao, Yan Zhang, Yue-Qi Wang, Dao-Zhen Jiang, Bo Tang, and Xue-Ming Zhang
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Apoptosis ,Inflammation ,Mouse ,Testicular inflammation ,Schizandrin B ,Sertoli cell ,Medicine ,Science - Abstract
Abstract Bacterial testicular inflammation is one of the important causes of male infertility. Using plant-derived compounds to overcome the side effects of antibiotics is an alternative treatment strategy for many diseases. Schizandrin B (SchB) is a bioactive compound of herbal medicine Schisandra chinensis which has multiple pharmacological effects. However its effect and the mechanism against testicular inflammation are unknown. Here we tackled these questions using models of lipopolysaccharide (LPS)-induced mice and -Sertoli cells (SCs). Histologically, SchB ameliorated the LPS-induced damages of the seminiferous epithelium and blood-testicular barrier, and reduced the production of pro-inflammatory mediators in mouse testes. Furthermore, SchB decreased the levels of pro-inflammatory mediators and inhibited the nuclear factor kB (NF-κB) and MAPK (especially JNK) signaling pathway phosphorylation in LPS-induced mSCs. The bioinformatics analysis based on receptor prediction and the molecular docking was further conducted. We targeted androgen receptor (AR) and illustrated that AR might bind with SchB in its function. Further experiments indicate that the AR expression was upregulated by LPS stimulation, while SchB treatment reversed this phenomenon; similarly, the expression of the JNK-related proteins and apoptotic-related protein were also reversed after AR activator treatment. Together, SchB mitigates LPS-induced inflammation and apoptosis by inhibiting the AR-JNK pathway.
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- 2024
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5. Differences in intestinal and renal Ca and P uptake in three different breeds of growing-finishing pigs
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Chenjian Li, Md. Abul Kalam Azad, Qian Zhu, Yating Cheng, Jue Gui, Bo Song, Zhenlei Zhou, and Xiangfeng Kong
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Breed ,bone characteristics ,calcium ,growing-finishing pigs ,phosphorus ,Veterinary medicine ,SF600-1100 - Abstract
This study investigated the differences in bone growth and turnover and calcium (Ca) and phosphorus (P) uptake among three different breeds of growing-finishing pigs. Ninety healthy Duroc, Xiangcun black (XCB), and Taoyuan black (TYB) pigs (30 pigs per breed) at 35 day-old (D) with the average body weight (BW) of their respective breed were assigned and raised to 185 D. The results showed that Duroc pigs had higher bone weight and length than the XCB and TYB pigs at 80, 125, and 185 D and the bone index at 185 D (p
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- 2024
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6. Core Problems and Solving Strategies of the Research on the Law of TCM Syndrome and Treatment Based on Data Driven
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ZHEN Qian, ZHU Rong, WANG Zhongrui, CUI Weifeng, YAN Shuxun, SHAO Mingyi, YU Haibin, FU Yu
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traditional chinese medicine therapy ,the law of syndrome and treatment ,data driven ,data mining ,electronic medical record ,core problems ,solving strategies ,Medicine - Abstract
Treatment based on syndrome differentiation is the core diagnostic and therapeutic thinking of traditional Chinese medicine (TCM), which is the key to determine clinical efficacy. Nowadays, research based on clinical data is the main method to explore the law of TCM syndrome and treatment, but the internal relationship of the key factors of "disease-syndrome-formula-medicine-effect" has not been truly and comprehensively analyzed, resulting in low clinical value of research results. Therefore, the author systematically sorted out the core problems of poor matching between electronic medical record and clinical research, the effect of data governance on data accuracy, difficulties to discover the law of TCM syndrome and treatment by data analysis methods. In addition, in the context of data driven, the big data platform of TCM clinical research should be established, and the data governance and analysis technology with artificial intelligence as the core should be developed, so as to realize the integration of clinical practice and research, providing new ideas and methods for the research of the law of TCM syndrome and treatment and promoting the development of TCM.
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- 2024
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7. Novel molecular subtypes of METex14 non-small cell lung cancer with distinct biological and clinical significance
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Shengnan Chen, Tao Hu, Jikai Zhao, Qian Zhu, Jin Wang, Zhan Huang, Chan Xiang, Ruiying Zhao, Changbin Zhu, Shun Lu, and Yuchen Han
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Not all MET exon 14 skipping (METex14) NSCLC patients benefited from MET inhibitors. We hypothesized an inter-tumoral heterogeneity in METex14 NSCLC. Investigations at genomic and transcriptomic level were conducted in METex14 NSCLC samples from stage I-III and recurrent/metastatic patients as discovery and validation cohort. Four molecular subtypes were discovered. MET-Driven subtype, with the worst prognosis, displayed MET overexpression, enrichment of MET-related pathways, and higher infiltration of fibroblast and regulatory T cells. Immune-Activated subtype having the most idea long-term survival, had higher tertiary lymphoid structures, spatial co-option of PD-L1+ cancer cells, and GZMK+ CD8+ T cell. FGFR- and Bypass-Activated subtypes displayed FGFR2 overexpression and enrichments of multiple oncogenic pathways respectively. In the validation cohort, patients with MET-Driven subtype had better response to MET inhibitors than those with MET overexpression. Thus, molecular subtypes of METex14 NSCLC with distinct biological and clinical significance may indicate more precise therapeutic strategies for METex14 NSCLC patients.
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- 2024
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8. Evaluation of Drought Resistance and Quality of Different Rice Hybrid Combinations
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Yiru Li, Muhammad Ahmad Hassan, Qian Zhu, Wuyun Fang, Yueming Yi, Sumei Duan, Haibing Yu, and Shimei Wang
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rice ,drought-resistant ,drought stress ,quality ,selection system ,Environmental technology. Sanitary engineering ,TD1-1066 ,Environmental sciences ,GE1-350 - Abstract
Rice is an integral component of the daily food consumptions in China. Drought stress diminishes rice productivity and deteriorates its quality. To further improve the identification and selection system of drought-tolerant rice varieties, this experiment used 130 new rice hybrid combinations as research materials and water stress was carried out during the whole life span, with normal water management as the control, so as to construct a synergistic evaluation standard of drought-tolerance of rice in terms of yield and quality by examining the characteristics of plant height, fruiting rate, yield per plant, and quality. The study showed that (1) the coefficients of variation of the drought tolerance coefficients of the 11 indexes ranged from 3.50% to 44.35%, with the largest coefficient of variation being the yield per plant at 44.35% and the smallest being the grain length at 3.50%. According to the principal component analysis, the cumulative contribution of the first four principal components was 73.022%, which were the total number of grains, the number of solid grains, the effective panicles and plant height. The correlation analysis showed that the drought tolerance composite evaluation value was extremely significantly correlated with plant height, effective panicles, total grain number, number of solid grains, fruiting rate, thousand grain weight and grain width. Based on the results of stepwise regression analysis, the number of grains, plant height and thousand grain weight can be used as drought-resistant identification indexes. (2) Based on the variation characteristics of protein, brown rice rate, refined rice rate, whole refined rice rate and straight-chain starch content, 50 high-quality combinations were selected. The results of cluster analysis showed that the 50 rice combinations were divided into three groups, Group I strong drought-resistant with materials HD009, HD024, HD171, HD207, HD432, HD447, HD0451, a total of 7 materials up to the first level of rice indicators; Group II medium drought-resistant with 21 materials up to the first level of rice indicators; Group III drought-sensitive material HD522 up to the first level of rice indicators.
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- 2024
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9. Follow-up study to explore the relationship between Neutrophil to lymphocyte ratio and impaired fasting glucose—using the group-based trajectory modeling
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Xuekui Liu, Gangshan Peng, Ran Liu, Xiu Zang, Caiyan Zou, Haojie Sun, Qian Zhu, Houfa Geng, and Jun Liang
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Neutrophil to lymphocyte ratio ,Impaired fasting glucose ,Body mass index ,Group-Based Trajectory Modeling ,Medicine ,Science - Abstract
Abstract Previous studies have indicated a link between neutrophil to lymphocyte ratio (NLR) and impaired fasting glucose (IFG), but the findings have been disputed. By conducting a real-world follow-up study, we can monitor the development of diseases and confirm the connection between NLR and IFG. A total of 1168 patients without IFG or T2DM were followed up for six years. At baseline, participants' NLR levels, fasting plasma glucose and other clinical characteristics were recorded. During the follow-up period, NLR levels and the prevalence of IFG were recorded. Ultimately, 45 individuals were lost to follow-up, leaving 1,123 participants for analysis. Using Group-Based Trajectory Modeling (GBTM), the sample was divided into three groups. The prevalence of IFG in the three groups was 12.1%, 19.4%, and 20.85%, respectively. Compared with the low-level NLR group, the hazard ratio of IFG in the moderate-level NLR group and high-level NLR group were 1.628 (1.109–2.390) and 1.575 (1.001–2.497), respectively. There was a significant interaction effect of BMI and NLR on the risk of IFG (P
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- 2024
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10. Association of hospital safety climate and compliance with occupational safety practices among nurse interns: A cross‐sectional study using canonical correlation analysis
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Shan He, Zheng‐liang Li, Ying Wu, Xin Chen, Yi‐jun Chen, Wen‐feng Chen, Qian‐zhu Chen, and Fang‐fang Xiong
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canonical correlation analysis ,compliance ,nurse intern ,occupational health ,safety climate ,Medicine - Abstract
Abstract Background and Aims Nurse interns may be at a similar or higher risk than registered nurses. The key elements and mechanisms involved in the effects of safety climate on safety performance are not well understood. This study explores the relationship between the perceived hospital safety climate and compliance with occupational safety practices among nurse interns. Methods A cross‐sectional study was conducted among 178 nurse interns in three tertiary university hospitals in Chongqing city, China. The Chinese version of the Hospital Safety Climate Scale (HSCS) was used to measure the perceived hospital safety climate of nurse interns. Compliance behavior was measured using the Compliance with Occupational Safety Practice Scale (COSPS). Canonical correlation analysis and multiple linear regression modeling were used to examine their relationship. Results Total scores for the HSCS and COSPS were 92 (80,100) and 185 (175,185) [M (P25, P75)], respectively. Canonical correlation coefficients for canonical variates 1 and 2 were 0.636 (p
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- 2024
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11. New insights into the increased risk of migraines from COVID-19 infection and vaccination: a Mendelian randomization study
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Jin Yang, Xiaoli Song, Lei Shi, Shuhao Du, Jieying Zhang, Gang Huang, Xuancheng Zhou, Hao Chi, and Qian Zhu
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COVID-19 ,COVID-19 vaccination ,migraine ,GWAS ,Mendelian randomization study ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
IntroductionMigraine is a prevalent neurological disorder characterized by recurrent attacks, leading to a substantial global disease burden. Recent observational studies have reported the onset and worsening of migraine following COVID-19 infection and vaccination. However, traditional observational study designs have limitations in controlling for confounding factors, potentially resulting in biased and inconsistent conclusions. To address this, we applied Mendelian randomization (MR) to investigate the causal relationship between COVID-19 infection and vaccination with migraine.MethodsThis study utilized summary-level genome-wide association study (GWAS) data from the GWAS catalog and FinnGen database to evaluate the effects of varying degrees of COVID-19 infection and vaccination on migraine. We employed inverse variance weighted (IVW) fixed-effect and random-effect models as the primary methods for MR analysis, with MR-Egger and other approaches as complementary methods. Sensitivity analyses, including Cochran's Q test, MR-Egger intercept regression, and MR-PRESSO, were conducted to ensure robustness of the results.ResultsOur MR analysis revealed no significant causal association between COVID-19 infection and migraine. However, a significant causal association was found between COVID-19 vaccination and migraine (beta = 0.071, P = 0.034). The results were confirmed through a series of sensitivity tests, demonstrating the robustness of the findings.DiscussionThis study provides novel evidence of a significant causal link between COVID-19 vaccination and migraine, while no such association was observed with COVID-19 infection. These findings may have important implications for clinical practice, particularly in planning treatment adjustments and optimizing patient care for individuals with migraines in the context of COVID-19 vaccination.
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- 2024
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12. PACAP38 synergizes with irradiation to suppress the proliferation of multiple cancer cells via regulating SOX6/Wnt/β-catenin signaling
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Ran Wu, Chun-Xiang Cao, Lu Cao, Jun Su, Ke-Man Liao, Huan Li, Qian Zhu, Shu-Yan Li, Min Li, and Jia-Yi Chen
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PACAP38 ,cancer ,radiotherapy ,Sox6 ,Wnt/β-catenin ,histone ,Therapeutics. Pharmacology ,RM1-950 - Abstract
BackgroundPituitary adenylate cyclase-activating polypeptide (PACAP) 38 is an endogenous neuropeptide with diverse functions, notably its critical role in inhibiting tumor proliferation. Radiotherapy is an important step in the standard treatment modality of many tumors. Combining radiotherapy with therapeutic agents represents a new and promising trend aimed at enhancing radiation sensitivity and improving tumor treatment efficacy. However, the efficacy of PACAP38 combined with radiotherapy on tumors has not yet been studied.ObjectiveThis study aimed to investigate the impact of PACAP38, both independently and in combination with irradiation, on glioma and breast cancer cells, while elucidating the underlying mechanisms involved.MethodsWe investigated the impact of PACAP38 independently and combined it with irradiation on glioma and breast cancer cells in vitro through cell counting kit-8, clonogenic formation, Edu assays, and in vivo through a xenograft tumor model. We further explored the molecular mechanisms underlying the inhibitory effects of PACAP38 on tumors using RNA sequencing, western blotting assay, immunohistochemistry, and immunofluorescence analysis. Further investigation of gene function and the downstream mechanism was carried out through small interfering RNA and overexpression lentivirus targeting the SRY-related high-mobility group box 6 (SOX6) gene and western blotting assay.ResultsOur findings revealed that PACAP38 could effectively synergize with radiation to suppress the proliferation of glioma and breast cancer cells in vivo and in vitro. Molecular studies revealed that the inhibitory effect of PACAP38 on tumor cell proliferation was mediated by upregulating SOX6 protein expression through histone acetylation, thereby inhibiting the Wnt-β-catenin signaling pathway.ConclusionPACAP38 synergizes with irradiation to suppress the proliferation of multiple cancer cells via regulating SOX6/Wnt/β-catenin signaling. This combination may represent a promising therapeutic strategy for cancer treatment, potentially improving outcomes for patients undergoing radiotherapy.
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- 2024
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13. Research on the prediction and realization path of urban carbon peak along the Yellow River Basin
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Guangyao Deng, Qian Zhu, and Yingchen Shen
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Cities along the Yellow River basin ,Carbon peak ,Carbon emission prediction ,Machine learning fusion model ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
China and the international community attach great importance to sustainable development goals such as peaking carbon emissions. As an important energy base in China, the Yellow River Basin has significant capacity for reducing carbon emissions and increasing carbon sinks. To accelerate the achievement of carbon peak targets, social and natural development data as well as carbon emission data of 56 cities along the Yellow River Basin from 2000 to 2021 were analyzed. Based on the evaluation indicators of the model, the PSO-XGBoost-RF model was selected from the comparative models to predict the carbon peak of cities in the Yellow River Basin under different paths. Under the current economic and social development, cities along the Yellow River Basin in China are facing huge pressure to reduce emissions. It is expected to achieve a carbon peak in 2033, with a peak of 2,051,320,000 tons, so the target of reaching the peak of carbon emissions before 2030 will not be accomplished. But through comprehensive optimization of the industrial structure and reduction of energy consumption, cities along the Yellow River Basin as a whole may achieve carbon peak by 2026, with a peak of 1,917,132,000 tons.
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- 2024
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14. Phenotyping of FGF12AV52H mutation in mouse implies a complex FGF12 network
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Jianyu Huang, Chongyang Sun, Qian Zhu, Ge Wu, Yi Cao, Jiarui Shi, Shuyu He, Luyao Jiang, Jianxiang Liao, Lin Li, Cheng Zhong, and Yi Lu
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FGF12A ,Hippocampus ,Seizure susceptibility ,Cognition deficit ,Excitatory/inhibitory balance ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Pathogenic missense mutation of the FGF12 gene is responsible for a variable disease phenotypic spectrum. Disease-specific therapies require precise dissection of the relationship between different mutations and phenotypes. The lack of a proper animal model hinders the investigation of related diseases, such as early-onset epileptic encephalopathy. Here, an FGF12AV52H mouse model was generated using CRISPR/Cas9 technology, which altered the A isoform without affecting the B isoform. The FGF12AV52H mice exhibited seizure susceptibility, while no spontaneous seizures were observed. The increased excitability in dorsal hippocampal CA3 neurons was confirmed by patch-clamp recordings. Furthermore, immunostaining showed that the balance of excitatory/inhibitory neurons in the hippocampus of the FGF12AV52H mice was perturbed. The increases in inhibitory SOM+ neurons and excitatory CaMKII+ neurons were heterogeneous. Moreover, the locomotion, anxiety levels, risk assessment behavior, social behavior, and cognition of the FGF12AV52H mice were investigated by elevated plus maze, open field, three-chamber sociability, and novel object tests, respectively. Cognition deficit, impaired risk assessment, and social behavior with normal social indexes were observed, implying complex consequences of V52H FGF12A in mice. Together, these data suggest that the function of FGF12A in neurons can be immediate or long-term and involves modulation of ion channels and the differentiation and maturation of neurons. The FGF12AV52H mouse model increases the understanding of the function of FGF12A, and it is of great importance for revealing the complex network of the FGF12 gene in physiological and pathological processes.
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- 2024
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15. Stretchable complementary split-ring resonator using liquid metal and its application for cavity optomagnonics
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Guanqi Ye, Qian Zhu, Changqing Xu, Jianping Shi, and Fusheng Ma
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Physics ,QC1-999 - Abstract
Split-ring resonators (SRRs) and complementary split-ring resonators (CSRRs) are widely used in microwave devices. Considering its advantages of fluidity, high metallic conductivity, and extreme deformability, liquid metal is expected to enrich the tunability of SRR and CSRR. Here, a stretchable resonator based on CSRR, using liquid metal as the conducting layer and Ecoflex as the dielectric layer, is prepared by 3D printing. From the transmission spectra, we find that the resonant frequency can be continuously tuned from 3.77 to 3.40 GHz by stretching the resonator, which exhibits a stable quality factor, high ductility, excellent stretchability, and linearity. We then study the coupling between magnons in a yttrium iron garnet film and microwave photons in CSRRs. The anti-crossing effects are observed in transmission coefficient spectra by changing either the strength of the magnetic field or the size of the CSRR. The coupling strength g/2π is determined to be 63 MHz at a coupling frequency of 3.77 GHz and magnetic field of 800 Oe. Our findings could promote the development of reconfigurable metamaterials and cavity optomagnonics.
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- 2024
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16. Preoperative predictive model for the probability of lymph node metastasis in gastric cancer: a retrospective study
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Fei Teng, Qian Zhu, Xi-Lang Zhou, Yi-Bing Shi, and Han Sun
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computed tomography ,lymph node ,metastasis ,gastric cancer ,prediction ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundEffectively diagnosing lymph node (LN) metastasis (LNM) is crucial in determining the condition of patients with gastric cancer (GC). The present study was devised to develop and validate a preoperative predictive model (PPM) capable of assessing the LNM status of individuals with GC.MethodsA retrospective analysis of consecutive GC patients from two centers was conducted over the period from January 2021 to December 2023. These patients were utilized to construct a 289-patient training cohort for identifying LNM-related risk factors and developing a PPM, as well as a 90-patient testing cohort used for PPM validation.ResultsOf the GC patients included in the training cohort, 67 (23.2%) and 222 (76.8%) were respectively LNM negative and positive. Risk factors independently related to LNM status included cT3 invasion (P = 0.001), CT-reported LN (+) (P = 0.044), and CA199 value (P = 0.030). LNM risk scores were established with the following formula: score = -2.382 + 0.694×CT-reported LN status (+: 1; -: 0)+2.497×invasion depth (cT1: 0; cT2: 1; cT3: 2)+0.032×CA199 value. The area under the curve (AUC) values for PPM and CT-reported LN status were 0.753 and 0.609, respectively, with a significant difference between them (P < 0.001). When clinical data from the testing cohort was included in the PPM, the AUC values for the PPM and CT-reported LN status were 0.756 and 0.568 (P < 0.001).ConclusionsThe established PPM may be an effective technique for predicting the LNM status of patients preoperatively. This model can better diagnose LNM than CT-reported LN status alone, this model is better able to diagnose LNM.
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- 2024
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17. BSA-stabilized selenium nanoparticles ameliorate intracerebral hemorrhage's-like pathology by inhibiting ferroptosis-mediated neurotoxicology via Nrf2/GPX4 axis activation
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Xiao-Na Li, Li Lin, Xiao-Wei Li, Qian Zhu, Zhen-Yan Xie, Yong-Zhen Hu, Qing-Shan Long, Xiao-Bing Wei, Yi-Qi Wen, Li-Yang Zhang, Qi-Keng Zhang, Ying-Chao Jing, Xin-Hua Wei, and Xue-Song Li
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BSA-selenium nanoparticles ,Intracerebral hemorrhage ,Ferroptosis ,Cognitive function ,Nrf2-GPX4 axis ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Intracerebral hemorrhage (ICH) is a prevalent hemorrhagic cerebrovascular emergency. Alleviating neurological damage in the early stages of ICH is critical for enhancing patient prognosis and survival rate. A novel form of cell death called ferroptosis is intimately linked to hemorrhage-induced brain tissue injury. Although studies have demonstrated the significant preventive impact of bovine serum albumin-stabilized selenium nanoparticles (BSA-SeNPs) against disorders connected to the neurological system, the neuroprotective effect on the hemorrhage stroke and the mechanism remain unknown. Therefore, based on the favorable biocompatibility of BSA-SeNPs, h-ICH (hippocampus-intracerebral hemorrhage) model was constructed to perform BSA-SeNPs therapy. As expected, these BSA-SeNPs could effectively improve the cognitive deficits and ameliorate the damage of hippocampal neuron. Furthermore, BSA-SeNPs reverse the morphology of mitochondria and enhanced the mitochondrial function, evidenced by mitochondrial respiration function (OCR) and mitochondrial membrane potential (MMP). Mechanistically, BSA-SeNPs could efficiently activate the Nrf2 to enhance the expression of antioxidant GPX4 at mRNA and protein levels, and further inhibit lipid peroxidation production in erastin-induced ferroptotic damages. Taken together, this study not only sheds light on the clinical application of BSA-SeNPs, but also provides its newly theoretical support for the strategy of the intervention and treatment of neurological impairment following ICH.
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- 2024
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18. Context-Aware Tracking and Dynamic Introduction for Incomplete Utterance Rewriting in Extended Multi-Turn Dialogues.
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Xinnan Guo, Qian Zhu, Qiuhui Shi, Xuan Lin, Liubin Wang, DaqianLi DaqianLi, and Yongrui Chen 0002
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- 2024
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19. Make Interaction Situated: Designing User Acceptable Interaction for Situated Visualization in Public Environments.
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Qian Zhu 0010, Zhuo Wang, Wei Zeng 0004, Wai Tong, Weiyue Lin, and Xiaojuan Ma
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- 2024
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20. Ultrahigh performance passive radiative cooling by hybrid polar dielectric metasurface thermal emitters
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Yinan Zhang, Yinggang Chen, Tong Wang, Qian Zhu, and Min Gu
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radiative cooling ,dielectric metasurfaces ,machine learning ,thermal emitters ,Optics. Light ,QC350-467 - Abstract
Real-world passive radiative cooling requires highly emissive, selective, and omnidirectional thermal emitters to maintain the radiative cooler at a certain temperature below the ambient temperature while maximizing the net cooling power. Despite various selective thermal emitters have been demonstrated, it is still challenging to achieve these conditions simultaneously because of the extreme difficulty in controlling thermal emission of photonic structures in multidimension. Here we demonstrated hybrid polar dielectric metasurface thermal emitters with machine learning inverse design, enabling a high emissivity of ~0.92 within the atmospheric transparency window 8–13 μm, a large spectral selectivity of ~1.8 and a wide emission angle up to 80 degrees, simultaneously. This selective and omnidirectional thermal emitter has led to a new record of temperature reduction as large as ~15.4 °C under strong solar irradiation of ~800 W/m2, significantly surpassing the state-of-the-art results. The designed structures also show great potential in tackling the urban heat island effect, with modelling results suggesting a large energy saving and deployment area reduction. This research will make significant impact on passive radiative cooling, thermal energy photonics and tackling global climate change.
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- 2024
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21. Comparative characteristics of early-onset vs. late-onset advanced colorectal cancer: a nationwide study in China
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Hongwei Liu, Huifang Xu, Yin Liu, Yuqian Zhao, Xi Zhang, Yanqin Yu, Lingbin Du, Yunyong Liu, Wenjun Wang, Helu Cao, Li Ma, Juanxiu Huang, Ji Cao, Li Li, Yanping Fan, Xiaofen Gu, Changyan Feng, Qian Zhu, Xiaohui Wang, Jingchang Du, Shaokai Zhang, and Youlin Qiao
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Early-onset colorectal cancer ,Late-onset colorectal cancer ,Clinical epidemiology features ,Health-related quality of life ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The incidence of early-onset colorectal cancer (EOCRC, diagnosed in patients under the age of 50 years) has been increasing around the world. Here, we aimed to systematically identify distinctive features of EOCRC. Methods From 2020 to 2021, we conducted a nationwide survey in 19 hospitals, collecting data on advanced CRC patients’ demographics, clinical features, disease knowledge, medical experiences, expenditures, and health-related quality of life (HRQOL). We compared these features between EOCRC and late-onset colorectal cancer (LOCRC, ≥ 50 years old) groups and analyzed the association between EOCRC and HRQOL using multivariate linear regression. Findings In total, 991 patients with EOCRC and 3581 patients with LOCRC were included. Compared to the LOCRC group, the EOCRC group had higher levels of education, were more informed about the risk factors for CRC, were more likely to have widespread metastases throughout the body, were more inclined to undergo gene testing, and were more likely to opt for targeted therapy, radiotherapy, and chemotherapy. However, HRQOL in the EOCRC group was similar to that of the LOCRC group, and no significant association was observed between EOCRC and HRQOL (beta: -0.753, P value: 0.307). Interpretation In Chinese patients, EOCRC patients had more aggressive features. Despite undergoing more intensified treatments and gene testing, they had similar HRQOL compared with LOCRC. These findings advocate for a more tailored approach to treatment, especially for young CRC patients with advanced TNM stages and metastasis.
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- 2024
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22. Comprehensive analysis of immunogenic cell death-related gene and construction of prediction model based on WGCNA and multiple machine learning in severe COVID-19
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Chunyu Li, Ke Wu, Rui Yang, Minghua Liao, Jun Li, Qian Zhu, Jiayi Zhang, and Xianming Zhang
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COVID-19 ,Immunogenic cell death ,Machine learning ,Immune cell infiltration ,Medicine ,Science - Abstract
Abstract The death of coronavirus disease 2019 (COVID-19) is primarily due to from critically ill patients, especially from ARDS complications caused by SARS-CoV-2. Therefore, it is essential to contribute an in-depth understanding of the pathogenesis of the disease and to identify biomarkers for predicting critically ill patients at the molecular level. Immunogenic cell death (ICD), as a specific variant of regulatory cell death driven by stress, can induce adaptive immune responses against cell death antigens in the host. Studies have confirmed that both innate and adaptive immune pathways are involved in the pathogenesis of SARS-CoV-2 infection. However, the role of ICD in the pathogenesis of severe COVID-19 has rarely been explored. In this study, we systematically evaluated the role of ICD-related genes in COVID-19. We conducted consensus clustering, immune infiltration analysis, and functional enrichment analysis based on ICD differentially expressed genes. The results showed that immune infiltration characteristics were altered in severe and non-severe COVID-19. In addition, we used multiple machine learning methods to screen for five risk genes (KLF5, NSUN7, APH1B, GRB10 and CD4), which are used to predict COVID-19 severity. Finally, we constructed a nomogram to predict the risk of severe COVID-19 based on the classification and recognition model, and validated the model with external data sets. This study provides a valuable direction for the exploration of the pathogenesis and progress of COVID-19, and helps in the early identification of severe cases of COVID-19 to reduce mortality.
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- 2024
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23. Development of small intestinal barrier function and underlying mechanism in Chinese indigenous and Duroc piglets during suckling and weaning periods
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Sujuan Ding, Yating Cheng, Md Abul Kalam Azad, Qian Zhu, Pan Huang, and Xiangfeng Kong
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Chinese indigenous piglet ,Duroc piglet ,Immune function ,Intestinal barrier function ,Weaning stress ,Animal culture ,SF1-1100 - Abstract
This study explored the developmental changes in small intestinal barrier function and the potential regulatory roles of intestinal microbiota and metabolites in different breeds of piglets during suckling and weaning periods. Taoyuan black (TB), Xiangcun black (XB), and Duroc (DR) piglets (10 litters per breed; half male and half female) were selected for sampling to evaluate the intestinal barrier-related indexes and intestinal microbiota and metabolites at 1, 10, 21 (weaned), and 24 (3 d after weaning) d old. The results showed that weaning led to severe shedding of small intestinal microvilli and sparse microvilli arrangement. D-lactate level in the ileum of TB and XB piglets during suckling and weaning periods was lower (P
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- 2024
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24. Grain refinement and texture regulation mechanism of spin-formed commercially pure titanium cathode for electrolytic copper foil
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Xiao Cao, Qian-qian Zhu, Ya-hui Liu, Ke-xing Song, Shu-guo Jia, Hai-tao Liu, Wei-wei Lu, Meng He, and Qing Feng
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Spin-formed commercially pure titanium cathode ,Microstructure ,Recrystallization nucleation ,Texture ,Mining engineering. Metallurgy ,TN1-997 - Abstract
The grain refinement and texture regulation mechanism of spin-formed commercially pure titanium (CP–Ti) cathode during annealing were studied by electron back scatter diffraction (EBSD) and transmission electron microscopy (TEM). The results show that the CP-Ti is seriously deformed after spinning, and the internal strain forms are mainly tension in spinning direction (SD), compression in normal direction (ND), and shear in transverse direction (TD). The dynamic recrystallization occurs during the spinning process, and the recrystallization nucleation mechanism is mainly subgrain nucleation. When spin-formed CP-Ti is annealed at 500 °C, the well-defined substructures generated by fragmentation of primary grains during deformation, as well as the cellular substructures formed by rearrangement of high-density entangled dislocations during annealing can evolve into a large number of fine equiaxed and randomly oriented recrystallized grains. In this case, the subgrain nucleation-dominated recrystallization nucleation mechanism can significantly refine grains. When annealed at 560 °C, a large number of tongue-shaped nuclei with similar orientation to the original grain generated at the grain boundaries, the recrystallization nucleation is inferred to be dominated by grain boundary bulge mechanism. Different recrystallization nucleation mechanisms result in different annealing texture evolution behaviors. When annealed at 500 °C, in the rapid nucleation stage of recrystallization (before 30 min), the texture strength is gradually weakened due to many randomly oriented recrystallized nuclei. With increasing the time from 30 min to 60 min, the recrystallization nucleation and growth reach a dynamic equilibrium, the texture strength tends to be stable. When annealed at 560 °C, a large number of recrystallized grains with similar orientation to the original deformed grains are formed. Oriented nucleation results in a strong texture at the short annealing time (5 min), but the competitive growth of different orientations makes the texture strength gradually decrease with the prolongation of annealing time. In any case, the overall texture strength annealed at 560 °C is higher than that annealed at 500 °C under the same annealing time.
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- 2024
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25. Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions
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Tianxin Liu, Qian Zhu, Yan Kai, Trevor Bingham, Stacy Wang, Hye Ji Cha, Stuti Mehta, Thorsten M. Schlaeger, Guo-Cheng Yuan, and Stuart H. Orkin
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Science - Abstract
Abstract Although emerging evidence indicates that alterations in proteins within nuclear compartments elicit changes in chromosomal architecture and differentiation, the underlying mechanisms are not well understood. Here we investigate the direct role of the abundant nuclear complex protein Matrin3 (Matr3) in chromatin architecture and development in the context of myogenesis. Using an acute targeted protein degradation platform (dTAG-Matr3), we reveal the dynamics of development-related chromatin reorganization. High-throughput chromosome conformation capture (Hi-C) experiments revealed substantial chromatin loop rearrangements soon after Matr3 depletion. Notably, YY1 binding was detected, accompanied by the emergence of novel YY1-mediated enhancer-promoter loops, which occurred concurrently with changes in histone modifications and chromatin-level binding patterns. Changes in chromatin occupancy by Matr3 also correlated with these alterations. Overall, our results suggest that Matr3 mediates differentiation through stabilizing chromatin accessibility and chromatin loop-domain interactions, and highlight a conserved and direct role for Matr3 in maintenance of chromosomal architecture.
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- 2024
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26. Identification of copy number variations among fetuses with isolated ultrasound soft markers in pregnant women not of advanced maternal age
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Yunyun Liu, Sha Liu, Jianlong Liu, Ting Bai, Xiaosha Jing, Cechuan Deng, Tianyu Xia, Jing Cheng, Lingling Xing, Xiang Wei, Yuan Luo, Quanfang Zhou, Dan Xie, Yueyue Xiong, Ling Liu, Qian Zhu, and Hongqian Liu
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Copy number variants ,Ultrasound soft markers ,Noninvasive prenatal screening ,Positive predictive value ,Medicine - Abstract
Abstract Background Pathogenic (P) copy number variants (CNVs) may be associated with second-trimester ultrasound soft markers (USMs), and noninvasive prenatal screening (NIPS) can enable interrogate the entire fetal genome to screening of fetal CNVs. This study evaluated the clinical application of NIPS for detecting CNVs among fetuses with USMs in pregnant women not of advanced maternal age (AMA). Results Fetal aneuploidies and CNVs were identified in 6647 pregnant women using the Berry Genomics NIPS algorithm.Those with positive NIPS results underwent amniocentesis for prenatal diagnosis. The NIPS and prenatal diagnosis results were analyzed and compared among different USMs. A total of 96 pregnancies were scored positive for fetal chromosome anomalies, comprising 37 aneuploidies and 59 CNVs. Positive predictive values (PPVs) for trisomy 21, trisomy 18, trisomy 13, and sex chromosome aneuploidies were 66.67%, 80.00%, 0%, and 30.43%, respectively. NIPS sensitivity for aneuploidies was 100%. For CNVs, the PPVs were calculated as 35.59% and false positive rate of 0.57%. There were six P CNVs, two successfully identified by NIPS and four missed, of which three were below the NIPS resolution limit and one false negative. The incidence of aneuploidies was significantly higher in fetuses with absent or hypoplastic nasal bone, while that of P CNVs was significantly higher in fetuses with aberrant right subclavian artery (ARSA), compared with other groups. Conclusions NIPS yielded a moderate PPV for CNVs in non-AMA pregnant women with fetal USM. However, NIPS showed limited ability in identifying P CNVs. Positive NIPS results for CNVs emphasize the need for further prenatal diagnosis. We do not recommend the use of NIPS for CNVs screening in non-AMA pregnant women with fetal USM, especially in fetuses with ARSA.
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- 2024
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27. Physical Graph-Based Spatiotemporal Fusion Approach for Process Fault Diagnosis
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Fengzhen Zhang, Qibing Jin, Dazi Li, Yang Zhang, and Qian Zhu
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Chemistry ,QD1-999 - Published
- 2024
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28. Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes
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Ferran Nieto-Fabregat, Qian Zhu, Corinne Vivès, Yunqin Zhang, Angela Marseglia, Fabrizio Chiodo, Michel Thépaut, Diksha Rai, Suvarn S. Kulkarni, Flaviana Di Lorenzo, Antonio Molinaro, Roberta Marchetti, Franck Fieschi, Guozhi Xiao, Biao Yu, and Alba Silipo
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Chemistry ,QD1-999 - Published
- 2024
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29. Unveiling functionality and conducting two-sample mendelian randomization on WGCNA-identified oxidative stress-related hub genes in metabolic dysfunction-associated fatty liver disease
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Qian Zhu, Jiaqi Liu, Wuxuan Mei, and Changchun Zeng
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MAFLD ,Oxidative stress ,Mendelian randomization ,WGCNA ,Gene co-expression network ,Biology (General) ,QH301-705.5 ,Biochemistry ,QD415-436 - Abstract
Metabolic dysfunction-associated fatty liver disease (MAFLD) shows accelerated development under the impact of oxidative stress (OS). There is an imperative to identify OS-related biomarkers in MAFLD and explore their potential mechanistic insights. The objective of this study was to identify OS-related biomarkers in MAFLD and explore their potential mechanisms. DEG analysis was performed using GSE17470 and GSE24807 datasets. An investigative exploration utilizing WGCNA was executed to elucidate hub OS-related genes. The intersection of OS-related hub genes identified by WGCNA and DEGs was systematically employed for thorough analyses. A mendelian randomization (MR) study examined the causal effect of C-reactive protein (CRP) on MAFLD. 59 OS-related DEGs were identified in MAFLD. WGCNA revealed 100 OS-related hub genes in MAFLD. Sixteen OS-related genes have been delineated as critical components in MAFLD. Enrichment analyses, employing GO and KEGG pathways, revealed pathways enriched with these genes. Following PPI analyses, the highest-ranking ten hub genes demonstrating abnormal expression were determined. Ultimately, a two-sample MR analysis demonstrated a causal link between the hub gene CRP and the occurrence of MAFLD. In this study, we harnessed WGCNA to formulate a co-expression network and identified hub OS-related DEGs in MAFLD. Additionally, the hub gene CRP exhibited a significant correlation with the predisposition to MAFLD. These findings offer innovative perspectives on the applications of OS-associated genes in individuals afflicted with MAFLD.
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- 2024
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30. Sub-chronic toxicity of the active fraction of a modified Huang-Lian-Jie-Du Decoction
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Lan Wang, Wen Yang, Jia-Qian Zhu, Yan-feng Huang, Mei Zhong, Steven King Fan Loo, Siu Po Ip, Yan-Fang Xian, and Zhi-Xiu Lin
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Modified Huang-Lian-Jie-Du Decoction ,Safety ,Sub-chronic toxicity ,Rats ,Toxicology. Poisons ,RA1190-1270 - Abstract
A traditional Chinese herbal medicine formula named Huang-Lian-Jie-Du Decoction (HLJDD) has been used to cure various inflammatory diseases with a long history. However, one component of HLJDD Gardeniae fructus has remarkable liver and kidney toxicities. Therefore, it was altered with Dictamni cortex to form a modified HLJDD (MHLJDD). In this study, we aimed to evaluate the sub-chronic toxicity of the active fraction of MHLJDD (MHLJDD-F) in rats. Adult rats of both sexes were intragastrically administered with vehicle or MHLJDD-F (at the dose of 170, 340, and 680 mg/kg/day) once daily for 90 days. Half of the rats from each group were kept for an additional 30-day period to observe the drug withdrawal effect. The signs of toxicity and mortality of the rats were observed, and the body weight and food consumption were recorded. Blood was collected for hematological and biochemical analyses and major organs were weighed and harvested for histopathological examinations. The results revealed that no systemic toxicity of MHLJDD-F was found during the experiments. Organ coefficients and pathological alterations of major organs were comparable to the control rats. The no-observed adverse effect level (NOAEL) of MHLJDD-F was found up to 680 mg/kg/day. All these results demonstrated that long-term oral administration of MHLJDD-F did not cause significant toxicity, which is worthy to be widely applied as a new herbal medicine in pre-clinical and clinical studies.
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- 2024
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31. The Contemporary Art of Image Search: Iterative User Intent Expansion via Vision-Language Model.
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Yilin Ye, Qian Zhu 0010, Shishi Xiao, Kang Zhang 0001, and Wei Zeng 0004
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- 2024
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32. Self-Supervised Learning-For Underwater Acoustic Signal Classification With Mixup.
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Qisheng Xu, Jingfei Jiang, Kele Xu, Yong Dou, Caili Gao, Boqing Zhu, Kang You, and Qian Zhu
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- 2024
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33. Sensing-Communication Co-Design for UAV Swarm-Assisted Vehicular Network in Perspective of Doppler.
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Qian Zhu, Rongke Liu, Zijie Wang, Qirui Liu, and Changwen Chen
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- 2024
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34. Albino lethal 13, a chloroplast‐imported protein required for chloroplast development in rice
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Xiaoqiong Guo, Chunli Wang, Qian Zhu, Wenhua Dongchen, Xiaoling Zhang, Wei Li, Hui Zhang, Cui Zhang, Zar Ni Naing Nant Nyein, Mengting Li, Lijuan Chen, and Dongsun Lee
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albino gene ,chloroplast development ,OsAL13 ,rice (Oryza sativa L.) ,Botany ,QK1-989 - Abstract
Abstract Chloroplasts play a vital role in plant growth and development, which are the main sites of photosynthesis and the production of hormones and metabolites. Despite their significance, the regulatory mechanisms governing chloroplast development remain unclear. In our investigation, we identified a rice mutant with defective chloroplasts in rice (Oryza sativa L.), named albino lethal 13 (osal13), which displayed a distinct albino phenotype in leaves, ultimately resulting in seedling lethality. Molecular cloning revealed that OsAL13 encodes a novel rice protein with no homologous gene or known conserved domain. This gene was located in the chloroplast and exhibited constitutive expression in various tissues, particularly in green tissues and regions of active cell growth. Our study's findings reveal that RNAi‐mediated knockdown of OsAL13 led to a pronounced albino phenotype, reduced chlorophyll and carotenoid contents, a vesicle chloroplast structure, and a decrease in the expression of chloroplast‐associated genes. Consequently, the pollen fertility and seed setting rate were lower compared with the wild type. In contrast, the overexpression of OsAL13 resulted in an increased photosynthetic rate, a higher total grain number per panicle, and enhanced levels of indole‐3‐acetic acid (IAA) in the roots and gibberellin A3 (GA3) in the shoot. These outcomes provide new insights on the role of OsAL13 in regulating chloroplast development in rice.
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- 2024
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35. YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair
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Tian-Shu Kang, Yong-Ming Yan, Yuan Tian, Jun Zhang, Minghui Zhang, Yuxin Shu, Jinbo Huang, Jing He, Cheng-Tian Tao, Qian Zhu, Jinke Gu, Xiaopeng Lu, Yong-Xian Cheng, and Wei-Guo Zhu
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Pharmacology ,Small molecule ,Natural product biochemistry ,Molecular biology experimental approach ,Science - Abstract
Summary: The NAD+-dependent deacetylase SIRT7 is a pivotal regulator of DNA damage response (DDR) and a promising drug target for developing cancer therapeutics. However, limited progress has been made in SIRT7 modulator discovery. Here, we applied peptide-based deacetylase platforms for SIRT7 enzymatic evaluation and successfully identified a potent SIRT7 inhibitor YZL-51N. We initially isolated bioactive YZL-51N from cockroach (Periplaneta americana) extracts and then developed the de novo synthesis of this compound. Further investigation revealed that YZL-51N impaired SIRT7 enzymatic activities through occupation of the NAD+ binding pocket. YZL-51N attenuated DNA damage repair induced by ionizing radiation (IR) in colorectal cancer cells and exhibited a synergistic anticancer effect when used in combination with etoposide. Overall, our study not only identified YZL-51N as a selective SIRT7 inhibitor from insect resources, but also confirmed its potential use in combined chemo-radiotherapy by interfering in the DNA damage repair process.
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- 2024
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36. Fermented Aronia melanocarpa pomace improves the nutritive value of eggs, enhances ovarian function, and reshapes microbiota abundance in aged laying hens
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Zhihua Li, Binghua Qin, Ting Chen, Xiangfeng Kong, Qian Zhu, Md. Abul Kalam Azad, Yadong Cui, Wei Lan, and Qinghua He
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aged laying hens ,nutritive value ,fermented Aronia melanocarpa pomace ,ovarian function ,microbiota ,Microbiology ,QR1-502 - Abstract
IntroductionThere is a decline in the quality and nutritive value of eggs in aged laying hens. Fruit pomaces with high nutritional and functional values have gained interest in poultry production to improve the performance.MethodsThe performance, egg nutritive value, lipid metabolism, ovarian health, and cecal microbiota abundance were evaluated in aged laying hens (320 laying hens, 345-day-old) fed on a basal diet (control), and a basal diet inclusion of 0.25%, 0.5%, or 1.0% fermented Aronia melanocarpa pomace (FAMP) for eight weeks.ResultsThe results show that 0.5% FAMP reduced the saturated fatty acids (such as C16:0) and improved the healthy lipid indices in egg yolks by decreasing the atherogenicity index, thrombogenic index, and hypocholesterolemia/hypercholesterolemia ratio and increasing health promotion index and desirable fatty acids (P < 0.05). Additionally, FAMP supplementation (0.25%−1.0%) increased (P < 0.05) the ovarian follicle-stimulating hormone, luteinizing hormone, and estrogen 2 levels, while 1.0% FAMP upregulated the HSD3B1 expression. The expression of VTG II and ApoVLDL II in the 0.25% and 0.5% FAMP groups, APOB in the 0.5% FAMP group, and ESR2 in the 1% FAMP group were upregulated (P < 0.05) in the liver. The ovarian total antioxidant capacity was increased (P < 0.05) by supplementation with 0.25%−1.0% FAMP. Dietary 0.5% and 1.0% FAMP downregulated (P < 0.05) the Keap1 expression, while 1.0% FAMP upregulated (P < 0.05) the Nrf2 expression in the ovary. Furthermore, 1.0% FAMP increased cecal acetate, butyrate, and valerate concentrations and Firmicutes while decreasing Proteobacteria (P < 0.05).ConclusionOverall, FAMP improved the nutritive value of eggs in aged laying hens by improving the liver–blood–ovary function and cecal microbial and metabolite composition, which might help to enhance economic benefits.
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- 2024
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37. Dietary probiotic and synbiotic supplementation starting from maternal gestation improves muscular lipid metabolism in offspring piglets by reshaping colonic microbiota and metabolites
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Qian Zhu, Md. Abul Kalam Azad, Ruixuan Li, Chenjian Li, Yang Liu, Yulong Yin, and Xiangfeng Kong
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Bama mini-pig ,colonic content ,lipid metabolism ,microbiota composition ,probiotics ,synbiotics ,Microbiology ,QR1-502 - Abstract
ABSTRACT Probiotics and synbiotics have been intensively used in animal husbandry due to their advantageous roles in animals’ health. However, there is a paucity of research on probiotic and synbiotic supplementation from maternal gestation to the postnatal growing phases of offspring piglets. Thus, we assessed the effects of dietary supplementation of these two additives to sows and offspring piglets on skeletal muscle and body metabolism, colonic microbiota composition, and metabolite profiles of offspring piglets. Pregnant Bama mini-pigs and their offspring piglets (after weaning) were fed either a basal diet or a basal diet supplemented with antibiotics, probiotics, or synbiotics. At 65, 95, and 125 days old, eight pigs per group were euthanized and sampled for analyses. Probiotics increased the intramuscular fat content in the psoas major muscle (PMM) at 95 days old, polyunsaturated fatty acid (PUFA) and n-3 PUFA levels in the longissimus dorsi muscle (LDM) at 65 days old, C16:1 level in the LDM at 125 days old, and upregulated ATGL, CPT-1, and HSL expressions in the PMM at 65 days old. Synbiotics increased the plasma HDL-C level at 65 days old and TC level at 65 and 125 days old and upregulated the CPT-1 expression in the PMM at 125 days old. In addition, probiotics and synbiotics increased the plasma levels of HDL-C at 65 days old, CHE at 95 days old, and LDL-C at 125 days old, while decreasing the C18:1n9t level in the PMM at 65 days old and the plasma levels of GLU, LDH, and TG at 95 days old. Microbiome analysis showed that probiotic and synbiotic supplementation increased colonic Actinobacteria, Firmicutes, Verrucomicrobia, Faecalibacterium, Pseudobutyrivibrio, and Turicibacter abundances. However, antibiotic supplementation decreased colonic Actinobacteria, Bacteroidetes, Prevotella, and Unclassified_Lachnospiraceae abundances. Furthermore, probiotic and synbiotic supplementation was associated with alterations in 8, 7, and 10 differential metabolites at three different age stages. Both microbiome and metabolome analyses showed that the differential metabolic pathways were associated with carbohydrate, amino acid, and lipid metabolism. However, antibiotic supplementation increased the C18:1n9t level in the PMM at 65 days old and xenobiotic biodegradation and metabolism at 125 days old. In conclusion, sow-offspring’s diets supplemented with these two additives showed conducive effects on meat flavor, nutritional composition of skeletal muscles, and body metabolism, which may be associated with the reshaping of colonic microbiota and metabolites. However, antibiotic supplementation has negative effects on colonic microbiota composition and fatty acid composition in the PMM.IMPORTANCEThe integral sow-offspring probiotic and synbiotic supplementation improves the meat flavor and the fatty acid composition of the LDM to some extent. Sow-offspring probiotic and synbiotic supplementation increases the colonic beneficial bacteria (including Firmicutes, Verrucomicrobia, Actinobacteria, Faecalibacterium, Turicibacter, and Pseudobutyrivibrio) and alters the colonic metabolite profiles, such as guanidoacetic acid, beta-sitosterol, inosine, cellobiose, indole, and polyamine. Antibiotic supplementation in sow-offspring's diets decreases several beneficial bacteria (including Bacteroidetes, Actinobacteria, Unclassified_Lachnospiraceae, and Prevotella) and has a favorable effect on improving the fatty acid composition of the LDM to some extent, while presenting the opposite effect on the PMM.
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- 2024
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38. Comparative physiological and transcriptomic characterization of rice (Oryza Sativa L.) root seedlings under phosphorus deficiency
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Qian Zhu, Yiru Li, Muhammad Ahmad Hassan, Wuyun Fang, and Shimei Wang
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Rice ,Root seedlings ,Phosphorus deficiency ,Transcriptome ,Physiology ,Plant ecology ,QK900-989 - Abstract
Phosphorus (P) is essential for optimal growth, development, and metabolic functioning in rice. In this research study, we compared the physiologies and transcriptomes of root seedlings of two rice varieties, upland rice (LH1) and lowland rice (IR26), under the treatments of normal P application (NP: 300 μM) and low P application (LP: 10 μM). The results demonstrated that the plant biomass of LH1 and IR26 was reduced by 10.0% and 27.8% in the LP treatment compared to the NP treatment (control), respectively. The P deficiency substantially affected the enzymatic activities in the roots of LH1 and IR26, which are vital for carbon and energy metabolism. Transcriptomic results identified 24,193 genes in all samples, and over 5000 differentially expressed genes (DEGs) were identified in both varieties under LP compared with their controls. KEGG analysis showed the functional categories for DEGs, which mainly included phenylpropanoid biosynthesis, glutathione metabolism, plant hormone signal transduction, photosynthesis, and carbon fixation in photosynthetic organisms. The DEGs involved in the glutathione metabolism, carbon fixation, and photosynthesis in photosynthetic pathways were downregulated by P deficiency. The DEGs involved in the metabolism of plant hormone signal transduction and carbohydrate transition for LH1 and IR26 exhibited different defense responses to the P deficiency in upland and lowland rice. The genes engaged in plant hormone signal transduction and carbohydrate fixation are anticipated to play key roles in improving the upland and lowland rice adaptation to P-deficient conditions. The results of this investigation have established a theoretical basis for strengthening our insight into the P tolerance mechanism in lowland and upland rice.
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- 2024
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39. Dietary vitamin B6 intake and stroke are negatively associated in adults: A cross-sectional study from the NHANES
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Chao Wang, Bo Li, Qian Zhu, Qikeng Zhang, Zhenyan Xie, Huixi Xie, and Xuesong Li
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Stroke ,Vitamin B6 intake ,Protective factor ,Nutrition ,NHANES ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background: The relationship between dietary vitamin B6 and stroke risk is controversial; thus, we analyzed their correlation using data from the National Health and Nutrition Examination Survey (NHANES). Method: Data from 2005 to 2018 were collected from the NHANES database. Two 24-h dietary recalls and a standard questionnaire were used to evaluate vitamin B6 intake and stroke prevalence. We used logistic regression models to estimate the association between dietary vitamin B6 intake and stroke risk and investigated the nonlinear relationship between them using a restricted cubic spline (RCS). Sensitivity analysis was conducted using propensity score matching (PSM). Results: Among 24,214 participants, 921 were patients diagnosed with stroke, while 23,293 were without stroke. The multivariate logistic regression model revealed that individuals in the highest quartile of vitamin B6 consumption had a significantly lower stroke risk than those in the lowest quartile under the fully adjusted model (OR: 0.48, 95 % CI: 0.35–0.66, P
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- 2024
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40. New perspectives on migraine treatment: a review of the mechanisms and effects of complementary and alternative therapies
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Xiaoli Song, Qian Zhu, Lanqian Su, Lei Shi, Hao Chi, Yalan Yan, Mei Luo, Xibin Xu, Baohong Liu, Zhengyang Liu, and Jin Yang
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migraine ,pain management ,alternative therapy ,acupuncture ,complementary therapy ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Migraine is a prevalent and disabling neurovascular disorder, with women being more susceptible, characterized by unilateral throbbing headache, often accompanied by nausea and vomiting, and often associated with various comorbidities such as brain and cardiovascular diseases, which can have a serious impact on quality of life. Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the main first-line medications for the treatment of pain, long-term use often leads to side effects and drug addiction, which emphasizes the need to investigate alternative pain management strategies with fewer adverse effects. Complementary and alternative medicine is a viable pain intervention often used in conjunction with traditional medications, including acupuncture, herbs, moxibustion, transcutaneous electrical stimulation, bio-supplements, and acupressure, which offer non-pharmacological alternatives that are now viable pain management options. This review focuses on the mechanistic doctrine of migraine generation and the role and potential mechanisms of Complementary and Alternative Therapies (CAT) in the treatment of migraine, summarizes the research evidences for CAT as an adjunct or alternative to conventional therapies for migraine, and focuses on the potential of novel migraine therapies (calcitonin gene-related peptide (CGRP) antagonists and pituitary adenylyl cyclase-activating peptide (PACAP) antagonists) with the aim of evaluating CAT therapies as adjunctive or alternative therapies to conventional migraine treatment, thereby providing a broader perspective on migraine management and the design of treatment programs for more effective pain management.
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- 2024
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41. Effect of WC particle size on the microstructural evolution and tribological properties of laser cladding Ti-bearing Co-based WC reinforced coating
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Ji, Fengqin, Luo, Can, Pang, Ming, and Qian, Zhu
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- 2024
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42. Effectiveness of health management team program to enhance prevention of mother-to-child transmission of hepatitis B virus in Ningxia, China
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Chenglei Zhang, Yongxiang Huang, Liying Ji, Qian Zhu, Lixin Wang, and Jingjiao Wang
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Hepatitis B ,Mother-to-child transmission interruption ,Health management team ,Adverse outcomes ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Hepatitis B mother-to-child transmission interruption (PMTCT) poses a formidable challenge in underdeveloped regions of China. This study aims to evaluate the effectiveness of PMTCT and the health management team (HMT) model in Ningxia, China, as well as the risk factors for adverse outcomes. Methods The PMTCT + HMT model was established, and 360 pregnant women diagnosed with HBV infection in 2020–2022 were selected and divided into the control and the study groups based on different intervention modes. HBV serum markers and HBV DNA levels were assessed, the indicators of compliance behaviors and adverse outcomes were compared, and the factors influencing adverse outcomes were analyzed. Results The majority of subjects were residents of the local city, married, with secondary school or higher education, and employees of public sectors. The proportion of ethnic minorities was 40.8% and 34.2% in the control group and study group. HBeAg positivity was 23.3% and 26.3%, and the proportion with HBV DNA levels ≥ 2 × 105 IU/mL was 9.2% and 7.1%. Compared with the control group (PMTCT alone), the PMTCT + HMT model led to improved maternal knowledge (17.5% vs. 57.1%), voluntary counseling (34.2% vs. 63.3%), and testing (37.5% vs. 70.4%). The incidence of adverse pregnancy outcomes ((including miscarriage, preterm birth) decreased significantly (17.5% vs. 6.2%), as did adverse neonatal outcomes (low birth weight and congenital HBV) (26.9% vs. 10.5%). Adverse outcomes were associated with low educational attainment, non-locals, unmarried status, and ethnic minority identity. Additionally, HBeAg positivity and HBV DNA levels ≥ 2 × 105 IU/mL were risk factors for adverse outcomes. Conclusions The PMTCT + HMT model demonstrates significant effectiveness in preventing mother-to-child transmission of hepatitis B in Ningxia. The unique demographic structure of Ningxia region is closely linked to poor outcomes, emphasizing the importance of monitoring HBeAg status and HBV DNA viral load level.
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- 2024
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43. Modified Qing-Zao-Jiu-Fei decoction attenuated pulmonary fibrosis induced by bleomycin in rats via modulating Nrf2/NF-κB and MAPKs pathways
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Jia-Qian Zhu, Yuan-Yang Tian, Kam Leung Chan, Zhen Hu, Qing-Qing Xu, Zhi-Xiu Lin, and Yan-Fang Xian
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Modified Qing-Zao-Jiu-Fei Decoction (M-QZJFD) ,Bleomycin ,Pulmonary fibrosis ,Oxidative stress ,NF-κB/Nrf2 pathway ,MAPKs pathway ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Background Qing-Zao-Jiu-Fei Decoction (QZJFD) is a famous herbal formula commonly prescribed for the treatment of lung-related diseases in the ancient and modern times. Trichosanthis Fructus (TF) and Fritillariae Thunbergii Bulbus (FTB) are widely used for treatment of cough and pulmonary disease. In order to identify a more effective formula for treatment of pulmonary fibrosis, we intend to add TF and FTB in QZJFD to form a modified QZJFD (MQZJFD). In this study, we aims to explore MQZJFD as an innovative therapeutic agent for pulmonary fibrosis using bleomycin (BLM)-treated rats and to unravel the underlying molecular mechanisms. Methods BLM was given to SD rats by intra-tracheal administration of a single dose of BLM (5 mg/kg). QZJFD (3 g/kg) and MQZJFD (1, 2 and 4 g/kg) was given intragastrically daily to rats for 14 days (from day 15 to 28) after BLM administration for 14 consecutive days. Results MQZJFD was found to contain 0.29% of amygdalin, 0.020% of lutin, 0.077% of glycyrrhizic acid and 0.047% of chlorogenic acid. BLM treatment could induce collagen deposition in the lung tissues of rats, indicating that the pulmonary fibrosis rat model had been successfully established. MQZJFD have better effects than the original QZJFD in reducing the pulmonary structure damage and collagen deposition of rat lung fibrosis induced by BLM. MQZJFD could reduce the hydroxyproline content in lung tissues of BLM-treated rats. The biomarkers of fibrosis such as matrix metalloproteinase 9 (MMP9), collagen I and α-smooth muscle actin (α-SMA) were remarkably reduced after treatment with MQZJFD. MQZJFD also have anti-oxidant stress effects by inhibiting the level of malondialdehyde (MDA), but enhancing the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the level of glutathione (GSH) in the lung tissues of BLM-treated rats. Moreover, the MQZJFD markedly suppressed the over expressions of p-p65/p65 and p-IκBα/IκBα, but upregulated the Nrf2. MQZJFD also suppressed the protein expressions of p-ERK1/2/ERK1/2, p-p38/p38 and p-JNK/JNK in the lung tissues of BLM-treated rats. Conclusions MQZJFD could improve the pulmonary fibrosis induced by BLM in rats via inhibiting the fibrosis and oxidative stress via suppressing the activation of NF-κB/Nrf2 and MAPKs pathways.
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- 2024
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44. Diagnosis and treatment of passenger lymphocyte syndrome following secondary ABO-incompatible allogeneic hematopoietic stem cell transplantation
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Yingchun SHAO, Shiyuan ZHOU, Qian ZHU, Guanggang DOU, Xiao MA, Xiaojin WU, and Chao MA
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passenger lymphocyte syndrome(pls) ,hematopoietic stem cell transplantation(hsct) ,abo blood group system ,hemolysis ,Diseases of the blood and blood-forming organs ,RC633-647.5 ,Medicine - Abstract
Objective To investigate the clinical characteristics and diagnosis and treatment of passenger lymphocyte syndrome (PLS) in patients following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods A total of 489 patients who underwent allo-HSCT in Suzhou Hongci Hematology Hospital were retrospectively enrolled. The clinical process, diagnosis and treatment measures and prognosis of four patients complicated with PLS after transplantation were analyzed. Results Among the 489 patients, 4 were diagnosed with PLS. The blood types of donor/recipient ABO were all secondary incompatible (The blood type of donors were O and the recipients were A or B). The overall incidence of PLS in allo-HSCT was 0.82%(4/489)and 2.2%(4/179)in transplants with donor/recipient secondary incompatible ABO-blood types. PLS occured in 6-13 days after donor stem cell infusion. Clinical manifestations were dizziness and fatigue, low back pain, jaundice, deepening urine, rapid decrease in hemoglobin on laboratory tests, elevated indirect bilirubin and lactate dehydrogenase, positive urobilinogen, positive direct anti-human globulin test (DAT), and anti-A or anti-B antibodies against recipient red blood cells were detected in plasma. After the treatment of O-type washed red blood cells, methylprednisolone, gamma globulin, rituximab and other treatments, the hemolysis was improved. All patients achieved engraftment of neutrophil and platelet. Red blood cell transfusion was halted in 3 weeks. Conclusion PLS is a rare complication of allo-HSCT, which mainly occurs in allo-HSCT patients with secondary incompatibility of ABO blood group of donor/recipient. The clinical prognosis is good after properly treatment.
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- 2023
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45. Precise City-Scale Urban Water Body Semantic Segmentation and Open-Source Sampleset Construction Based on Very High-Resolution Remote Sensing: A Case Study in Chengdu
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Xi Cheng, Qian Zhu, Yujian Song, Jieyu Yang, Tingting Wang, Bin Zhao, and Zhanfeng Shen
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urban water body ,very high-resolution remote sensing ,CDUWD ,Ad-SegFormer ,semantic segmentation ,Chengdu ,Science - Abstract
Addressing the challenges related to urban water bodies is essential for advancing urban planning and development. Therefore, obtaining precise and timely information regarding urban water bodies is of paramount importance. To address issues such as incomplete extraction boundaries, mistaken feature identification, and omission of small water bodies, this study utilized very high-resolution (VHR) satellite images of the Chengdu urban area and its surroundings to create the Chengdu Urban Water Bodies Semantic Segmentation Dataset (CDUWD). Based on the shape characteristics of water bodies, these images were processed through annotation, cropping, and other operations. We introduced Ad-SegFormer, an enhanced model based on SegFormer, which integrates a densely connected atrous spatial pyramid pooling module (DenseASPP) and progressive feature pyramid network (AFPN) to better handle the multi-scale characteristics of urban water bodies. The experimental results demonstrate the effectiveness of combining the CDUWD dataset with the Ad-SegFormer model for large-scale urban water body extraction, achieving accuracy rates exceeding 96%. This study demonstrates the effectiveness of Ad-SegFormer in improving water body extraction and provides a valuable reference for extracting large-scale urban water body information using VHR images.
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- 2024
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46. Physiological and Transcriptomic Characterization of Rice Genotypes under Drought Stress
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Qian Zhu, Muhammad Ahmad Hassan, Yiru Li, Wuyun Fang, Jingde Wu, and Shimei Wang
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Oryza sativa L. ,photosynthesis ,differentially expressed genes (DEGs) ,transcriptional regulation ,recovery ,Agriculture - Abstract
Drought is a primary abiotic stress that inhibits rice (Oryza sativa L.) growth and development, and during the reproductive stage it has a negative impact on the rice seed-setting rate. This research study examined two rice lines, La-96 (drought sensitive) and La-163 (drought resistant), for drought stress treatment (with soil moisture at 20% for 7 days) and control (normal irrigation and kept soil moisture ≥40%). To elucidate the photosynthesis and molecular mechanisms underlying drought tolerance in rice, leaf photosynthetic traits and transcriptome sequencing were used to compare differences between two contrasting recombinant inbred lines (RIL) during drought and subsequent recovery at the booting stage. The rice line La-96 showed a significant decrease in seed-setting rate after being treated for seven days’ drought stress (from 86.64% to 22.75%), while La-163 was slightly affected (from 89.04% to 79.33%). The photosynthetic activities of both lines significantly decreased under the drought treatment, and these traits of La-163 recovered to a comparable level with the control after three days of rewatering. The transcriptome of both lines in three treatments (the control, drought stress, and subsequent recovery) were tested, and a total of 16,051 genes were identified, among which 10,566 genes were differentially expressed in various treatments and rice lines. Comprehensive gene expression profiles revealed that the specifically identified DEGs were involved in the ribosome synthesis and the metabolic pathway of photosynthesis, starch, and sucrose metabolism. The DEGs that are activated and respond quickly, as seen during recovery in the tolerant rice line, may play essential roles in regulating subsequent growth and development. This study uncovered the molecular genetic pathways of drought tolerance and extended our understanding of the drought tolerance mechanisms and subsequent recovery regulation in rice.
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- 2024
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47. Dietary Fermented Blueberry Pomace Supplementation Improves Small Intestinal Barrier Function and Modulates Cecal Microbiota in Aged Laying Hens
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Binghua Qin, Zhihua Li, Qian Zhu, Ting Chen, Wei Lan, Yadong Cui, Md. Abul Kalam Azad, and Xiangfeng Kong
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aged hens ,feed additive ,fruit pomace ,late laying period ,microbiota ,small intestine ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
This study aimed to investigate the effects of fermented blueberry pomace (FBP) on the intestinal barrier function and cecal microbiome of aged laying hens. A total of 320 Yukou Jingfen No. 8 laying hens (345-day-old) were randomly divided into a control group, 0.25% FBP group, 0.5% FBP group, or 1.0% FBP group. The results showed that the villus height (VH) in the jejunum of the 0.25–0.5% FBP groups and villus surface area in the jejunum of the 0.25% FBP group were higher (p < 0.05), while 0.25% FBP supplementation displayed a higher (p = 0.070) VH in the ileum compared to the control group. Mucin-2 expression was upregulated (p < 0.05) in the jejunum of the 0.5% FBP group and the ileum of the 0.25–0.5% FBP groups. Compared to the control group, interleukin (IL)-4 and IL-13 expressions were upregulated (p < 0.05) in the 1.0% FBP group. Microbiota analysis revealed that Prevotella abundance in the cecum of the 0.5–1.0% FBP groups was higher (p < 0.05) than in the 0.25% FBP group. In addition, microbial function prediction analysis showed that cecal microbiota in the 0.25% FBP group were mainly enriched by alanine/aspartate/glutamate metabolism and methane metabolism. Moreover, Spearman’s correlation analysis revealed the potential correlations between the abundance of the cecal microbiota and intestinal-barrier-function-related gene expressions, as well as the short-chain fatty acid content, of laying hens. In summary, dietary FBP supplementation enhanced intestinal barrier function by improving intestinal morphology, upregulating gene expressions related to barrier function, and altering the cecal microbiota of aged laying hens.
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- 2024
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48. DNAJA1 regulates protein ubiquitination and is essential for spermatogenesis in the testes of mice and rats
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Mao, Jing-jing, Dai, Xiao-yu, Liu, Yun-zi, Ren, Li-jun, Zhang, Ji-qian-zhu, Yan, Lang, Li, Jin-feng, Tian, Yi-jun, Zhu, Jiang-bo, and Chen, Ji-kuai
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- 2024
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49. Molecular mechanism of boosted hydrogen production by Thermoanaerobacterium thermosaccharolyticum with biochar revealed by transcriptome analysis
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Bu, Jie, Ju, Xue-Wen, Liang, Lu-Xin, Zhao, Qian-Zhu, Wei Tiong, Yong, Wu, Hai-Zhen, Wah Tong, Yen, and Zhu, Ming-Jun
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- 2024
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50. Towards Feature Engineering with Human and AI's Knowledge: Understanding Data Science Practitioners' Perceptions in Human&AI-Assisted Feature Engineering Design.
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Qian Zhu 0010, Dakuo Wang, Shuai Ma, April Yi Wang, Zixin Chen, Udayan Khurana, and Xiaojuan Ma
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- 2024
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