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13 results on '"Qian, Yu‐Xuan"'

2. Intermittent Fasting Targets Osteocyte Neuropeptide Y to Relieve Osteoarthritis.

Author

Qian, Yu‐Xuan, Rao, Shan‐Shan, Tan, Yi‐Juan, Wang, Zun, Yin, Hao, Wan, Teng‐Fei, He, Ze‐Hui, Wang, Xin, Hong, Chun‐Gu, Zeng, Hai‐Jin, Luo, Yi, Duan, Yan‐Xin, Zhu, Hao, Hu, Xin‐Yue, Zou, Ling, Zhang, Yan, Liu, Bing‐Bing, Wang, Zhen‐Xing, Du, Wei, and Chen, Chun‐Yuan

Subjects
*NEUROPEPTIDE Y, *JOINT diseases, *BONE cells, *DISEASE progression, *OSTEOARTHRITIS, *INTERMITTENT fasting
Abstract

Osteoarthritis is a highly prevalent progressive joint disease that still requires an optimal therapeutic approach. Intermittent fasting is an attractive dieting strategy for improving health. Here this study shows that intermittent fasting potently relieves medial meniscus (DMM)‐ or natural aging‐induced osteoarthritic phenotypes. Osteocytes, the most abundant bone cells, secrete excess neuropeptide Y (NPY) during osteoarthritis, and this alteration can be altered by intermittent fasting. Both NPY and the NPY‐abundant culture medium of osteocytes (OCY‐CM) from osteoarthritic mice possess pro‐inflammatory, pro‐osteoclastic, and pro‐neurite outgrowth effects, while OCY‐CM from the intermittent fasting‐treated osteoarthritic mice fails to induce significant stimulatory effects on inflammation, osteoclast formation, and neurite outgrowth. Depletion of osteocyte NPY significantly attenuates DMM‐induced osteoarthritis and abolishes the benefits of intermittent fasting on osteoarthritis. This study suggests that osteocyte NPY is a key contributing factor in the pathogenesis of osteoarthritis and intermittent fasting represents a promising nonpharmacological antiosteoarthritis method by targeting osteocyte NPY. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Aptamer-functionalized hydrogels promote bone healing by selectively recruiting endogenous bone marrow mesenchymal stem cells

Author

Gong, Jiang-Shan, primary, Zhu, Guo-Qiang, additional, Zhang, Yu, additional, Chen, Bei, additional, Liu, Yi-Wei, additional, Li, Hong-Ming, additional, He, Ze-Hui, additional, Zou, Jing-Tao, additional, Qian, Yu-Xuan, additional, Zhu, Sheng, additional, Hu, Xin-Yue, additional, Rao, Shan-Shan, additional, Cao, Jia, additional, Xie, Hui, additional, Wang, Zhen-Xing, additional, and Du, Wei, additional

Published
2023
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4. Glucocorticoid-induced loss of beneficial gut bacterial extracellular vesicles is associated with the pathogenesis of osteonecrosis

Author

Chen, Chun-Yuan, primary, Rao, Shan-Shan, additional, Yue, Tao, additional, Tan, Yi-Juan, additional, Yin, Hao, additional, Chen, Ling-Jiao, additional, Luo, Ming-Jie, additional, Wang, Zun, additional, Wang, Yi-Yi, additional, Hong, Chun-Gu, additional, Qian, Yu-Xuan, additional, He, Ze-Hui, additional, Liu, Jiang-Hua, additional, Yang, Fei, additional, Huang, Fei-Yu, additional, Tang, Si-Yuan, additional, and Xie, Hui, additional

Published
2022
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5. Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y (Adv. Sci. 24/2021)

Author

Zhang, Yan, primary, Chen, Chun‐Yuan, additional, Liu, Yi‐Wei, additional, Rao, Shan‐Shan, additional, Tan, Yi‐Juan, additional, Qian, Yu‐Xuan, additional, Xia, Kun, additional, Huang, Jie, additional, Liu, Xi‐Xi, additional, Hong, Chun‐Gu, additional, Yin, Hao, additional, Cao, Jia, additional, Feng, Shi‐Kai, additional, He, Ze‐Hui, additional, Li, You‐You, additional, Luo, Zhong‐Wei, additional, Wu, Ben, additional, Yan, Zi‐Qi, additional, Chen, Tuan‐Hui, additional, Chen, Meng‐Lu, additional, Wang, Yi‐Yi, additional, Wang, Zhen‐Xing, additional, Liu, Zheng‐Zhao, additional, Luo, Ming‐Jie, additional, Hu, Xiong‐Ke, additional, Jin, Ling, additional, Wan, Teng‐Fei, additional, Yue, Tao, additional, Tang, Si‐Yuan, additional, and Xie, Hui, additional

Published
2021
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6. Extracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength

Author

Liu, Jiang‐Hua, primary, Chen, Chun‐Yuan, additional, Liu, Zheng‐Zhao, additional, Luo, Zhong‐Wei, additional, Rao, Shan‐Shan, additional, Jin, Ling, additional, Wan, Teng‐Fei, additional, Yue, Tao, additional, Tan, Yi‐Juan, additional, Yin, Hao, additional, Yang, Fei, additional, Huang, Fei‐Yu, additional, Guo, Jian, additional, Wang, Yi‐Yi, additional, Xia, Kun, additional, Cao, Jia, additional, Wang, Zhen‐Xing, additional, Hong, Chun‐Gu, additional, Luo, Ming‐Jie, additional, Hu, Xiong‐Ke, additional, Liu, Yi‐Wei, additional, Du, Wei, additional, Luo, Juan, additional, Hu, Yin, additional, Zhang, Yan, additional, Huang, Jie, additional, Li, Hong‐Ming, additional, Wu, Ben, additional, Liu, Hao‐Ming, additional, Chen, Tuan‐Hui, additional, Qian, Yu‐Xuan, additional, Li, You‐You, additional, Feng, Shi‐Kai, additional, Chen, Yang, additional, Qi, Lu‐Yue, additional, Xu, Ran, additional, Tang, Si‐Yuan, additional, and Xie, Hui, additional

Published
2021
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7. Ångstrom-scale silver particle–embedded carbomer gel promotes wound healing by inhibiting bacterial colonization and inflammation

Author

Chen, Chun-Yuan, primary, Yin, Hao, additional, Chen, Xia, additional, Chen, Tuan-Hui, additional, Liu, Hao-Ming, additional, Rao, Shan-Shan, additional, Tan, Yi-Juan, additional, Qian, Yu-Xuan, additional, Liu, Yi-Wei, additional, Hu, Xiong-Ke, additional, Luo, Ming-Jie, additional, Wang, Zhen-Xing, additional, Liu, Zheng-Zhao, additional, Cao, Jia, additional, He, Ze-Hui, additional, Wu, Ben, additional, Yue, Tao, additional, Wang, Yi-Yi, additional, Xia, Kun, additional, Luo, Zhong-Wei, additional, Wang, Yang, additional, Situ, Wei-Yi, additional, Liu, Wen-En, additional, Tang, Si-Yuan, additional, and Xie, Hui, additional

Published
2020
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8. Fructose-coated Angstrom silver inhibits osteosarcoma growth and metastasis via promoting ROS-dependent apoptosis through the alteration of glucose metabolism by inhibiting PDK

Author

Hu, Xiong-Ke, primary, Rao, Shan-Shan, additional, Tan, Yi-Juan, additional, Yin, Hao, additional, Luo, Ming-Jie, additional, Wang, Zhen-Xing, additional, Zhou, Jin-Hua, additional, Hong, Chun-Gu, additional, Luo, Zhong-Wei, additional, Du, Wei, additional, Wu, Ben, additional, Yan, Zi-Qi, additional, He, Ze-Hui, additional, Liu, Zheng-Zhao, additional, Cao, Jia, additional, Wang, Yang, additional, Situ, Wei-Yi, additional, Liu, Hao-Ming, additional, Huang, Jie, additional, Wang, Yi-Yi, additional, Xia, Kun, additional, Qian, Yu-Xuan, additional, Zhang, Yan, additional, Yue, Tao, additional, Liu, Yi-Wei, additional, Zhang, Hong-Qi, additional, Tang, Si-Yuan, additional, Chen, Chun-Yuan, additional, and Xie, Hui, additional

Published
2020
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9. Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2

Author

Luo, Ming-Jie, primary, Rao, Shan-Shan, additional, Tan, Yi-Juan, additional, Yin, Hao, additional, Hu, Xiong-Ke, additional, Zhang, Yan, additional, Liu, Yi-Wei, additional, Yue, Tao, additional, Chen, Ling-Jiao, additional, Li, Li, additional, Huang, Ya-Rong, additional, Qian, Yu-Xuan, additional, Liu, Zheng-Zhao, additional, Cao, Jia, additional, Wang, Zhen-Xing, additional, Luo, Zhong-Wei, additional, Wang, Yi-Yi, additional, Xia, Kun, additional, Tang, Si-Yuan, additional, Chen, Chun-Yuan, additional, and Xie, Hui, additional

Published
2020
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12. Association between metabolic syndrome and knee osteoarthritis: a cross-sectional study.

Author

Dong-xing Xie, Jie Wei, Chao Zeng, Tuo Yang, Hui Li, Yi-lun Wang, Hui-zhong Long, Zi-ying Wu, Yu-xuan Qian, Kang-hua Li, Guang-hua Lei, Xie, Dong-Xing, Wei, Jie, Zeng, Chao, Yang, Tuo, Li, Hui, Wang, Yi-Lun, Long, Hui-Zhong, Wu, Zi-Ying, and Qian, Yu-Xuan

Subjects
JOINT diseases, METABOLIC syndrome, OSTEOARTHRITIS, KNEE radiography, HYPERTENSION
Abstract

Background: Osteoarthritis (OA) is the most prevalent chronic joint disease in China. The aim of this study was to examine the association between metabolic syndrome (MetS) and knee OA in a population-based Chinese study.Methods: Data included in this analysis is from a cross-sectional study, i.e., the Xiangya Hospital Health Management Center Study. MetS was diagnosed according to the criteria defined by the Chinese Diabetes Society. Radiographic knee OA was defined as changes equivalent to Kellgren-Lawrence (K-L) grade 2 or above at least one side. Associations between MetS and its components with OA were evaluated by conducting multivariable adjusted logistic regression.Results: A total of 5764 participants were included in the present study. The unadjusted OR (1.27, 95%CI: 1.10-1.47, P = 0.001), age-sex adjusted OR (1.17, 95%CI: 1.01-1.36, P = 0.041) and multivariable adjusted OR (1.17, 95%CI: 1.01-1.36, P = 0.043) all suggested a positive association between MetS and knee OA. Besides, its components (e.g., overweight, hypertension and dyslipidemia) were also associated with the prevalence of radiographic knee OA respectively, after adjusting for some confounding factors. In addition, with the accumulation of MetS components, the prevalence of knee OA increased. Furthermore, MetS as a whole was associated with the prevalence of knee osteophyte (OSP) (OR = 1.72, 95%CI: 1.42-2.09, P < 0.001), but not joint space narrowing (JSN) (OR = 1.06, 95%CI: 0.91-1.23, P = 0.449).Conclusions: The findings of the present study indicated that there was a positive association between the prevalence of MetS and knee OA. However, MetS as a whole was associated with the higher prevalence of knee OSP, but not JSN, which should shed light on our understanding the association between MetS and OA. [ABSTRACT FROM AUTHOR]

Published
2017
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13. Association Between Tibial Plateau Slopes and Anterior Cruciate Ligament Injury: A Meta-analysis.

Author

Wang YL, Yang T, Zeng C, Wei J, Xie DX, Yang YH, Long HZ, Xu B, Qian YX, Jiang SD, and Lei GH

Subjects
Anterior Cruciate Ligament diagnostic imaging, Anterior Cruciate Ligament surgery, Female, Humans, Magnetic Resonance Imaging, Male, Tibia diagnostic imaging, Tibia surgery, Anterior Cruciate Ligament pathology, Anterior Cruciate Ligament Injuries surgery, Tibia pathology
Abstract

Purpose: To investigate the associations of medial tibial plateau slope (MTPS), lateral tibial plateau slope (LTPS), and coronal tibial plateau slope (CTPS) with anterior cruciate ligament (ACL) injury both in the general population and in different gender subgroups., Methods: PubMed, Ovid, Embase, and Scopus databases were searched through from inception to August 31, 2016. Observational studies reporting associations of MTPS/LTPS/CTPS with ACL injury were retrieved for analysis. Either a fixed- or random-effects model was used to calculate the overall standardized mean difference (SMD). Reviews, meeting abstracts, cadaver or animal studies, and other studies without disclosing full text were excluded in this study., Results: A total of 29 studies were included. Subjects with ACL injury exhibited a significant increase in MTPS (SMD: 0.34 [95% confidence interval (CI): 0.18, 0.49]; P < .0001) and LTPS (SMD: 0.49 [95% CI: 0.30, 0.68]; P < .00001), but not in the CTPS (SMD: 0.09 [95% CI: -0.10, 0.27]; P = .36), compared with controls. Meanwhile, significant differences in MTPS and LTPS were observed in the male subgroup (SMD: 0.41 [95% CI: 0.20, 0.62]; P = .0001 and SMD: 0.55 [95% CI: 0.26, 0.85]; P = .0002, respectively) but not in the female (SMD: 0.31 [95% CI: -0.02, 0.64]; P = .06 and SMD: 0.26 [95% CI: -0.04, 0.56]; P = .09, respectively)., Conclusions: The present meta-analysis showed that the increases in MTPS and LTPS were overall risk factors of ACL injury. However, these slopes would only be considered as "at risk" for males, but not for females. In addition, it was also proved that CTPS was not a risk factor of ACL injury., Level of Evidence: Level III, meta-analysis of Level II and III studies., (Copyright © 2017 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.)

Published
2017
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