1. Coumarinolignoids and lignanoids from the stems and leaves of Sapium discolor
- Author
-
Gui-Jie Zhang, Ning Li, Qi-Min Pan, Hai-Bing Liao, Jiang-Ke Qin, Yong-Li Zhang, and Liang Dong
- Subjects
Phytochemicals ,Nitric Oxide ,Sapium ,01 natural sciences ,Lignin ,chemistry.chemical_compound ,Mice ,Coumarins ,Drug Discovery ,Ic50 values ,Animals ,Pharmacology ,Lariciresinol ,biology ,Molecular Structure ,Plant Stems ,010405 organic chemistry ,General Medicine ,biology.organism_classification ,0104 chemical sciences ,Plant Leaves ,010404 medicinal & biomolecular chemistry ,chemistry ,Microglia ,Single crystal ,Nuclear chemistry - Abstract
Two new coumarinolignoids, sapiumins D (1) and E (2), a new lignanoid, lariciresinol 9′-benzoate (3), together with six known coumarinolignoids (4–9) and eight known lignanoids (10–17), were isolated from the stems and leaves of Sapium discolor. The structures of the isolated compounds were elucidated by extensive spectroscopic methods, including NMR, MS, and single crystal X-ray diffraction experiments. Compounds 5, 10, 11, and 13 significantly inhibited nitric oxide production in lipopolysaccharide-induced BV-2 microglial cells, with IC50 values in the range of 2.13–11.37 μM.
- Published
- 2018