Search

AIM: To explore the effect of fundus laser combined with Qi Ming granule on diabetic retinopathy in stage Ⅲ.METHODS: Fifty six patients with Ⅲ stage diabetic retinopathy who were treated in our hospital from December 2017 to June 2018 were divided into control group(28 cases)and observation group(28 cases)according to the treatment method. The control group was treated with panretinal photocoagulation. The observation group was treated with Qi Ming granule combined with retinal laser photocoagulation. The best-corrected visual acuity(BCVA), mean defect of visual field(MD), and central macular thickness(CMT)were examined before photocoagulation and 1mo, 3mo and 6mo after photocoagulation to compare the retinal function between the two groups.RESULTS: The mean BCVA, MD and CMT values of the eyes in the PRP+ drug treatment group and the PRP treatment group were statistically significant(PPP>0.05).CONCLUSION: Qi Ming granule can alleviate the degree of laser photocoagulation damage to the retina, promote the rapid repair of laser damage, and reduce diabetic macular edema. It is worthy of popularization and application in the clinic.

AIM: To investigate the clinical efficacy of Qi Ming granule combined with macular grid laser photocoagulation in the treatment of diabetic retinopathy(DR)with diabetic macular edema(DME). METHODS: The clinical data of 50 patients(98 eyes)with DME treated in our hospital from March 2014 to March 2017 were retrospectively analyzed. Patients were randomly divided into two group, 25 patients(48 eyes)treated with macular grid laser photocoagulation were included into the control group. On the basis of this, 25 patients(50 eyes)treated with Qi Ming granule were included into observation group. The central macular thickness(CMT)and best corrected visual acuity(BCVA)between two groups were evaluated and compared after detected by optical coherence tomography(OCT)and fundus fluorescein angiography(FFA)at 7d, 1 and 3mo post-treatment. RESULTS: The total effective rate was 94% in the observation group with 47 effective eyes, which was was significantly higher than 83% in the control group with 40 effective eyes(PPPCONCLUSION: The clinical efficacy of Qi Ming granule combined with macular grid laser photocoagulation in the treatment of diabetic retinopathy with macular edema is effective, which can reduce CMT, improve eyesight.

AIM:To investigate the effect of a Chinese medicine(Qi Ming granule)on the retinal and choroidal circulation in diabetes patients. METHODS: According to the results of fundus fluorescein angiography(FFA), all the 45 diabetes patients were divided into no diabetic retinopathy(NDR)group and nonproliferative diabetic retinopathy(NPDR)group. All subjects were examined by FFA and indocyanine green angiography(ICGA)at the same time. After taken Qi Ming granule for 3mo, all subjects were examined by the same method. FFA and ICGA were used to evaluate the retinal and choroidal circulation and their features. The key points were filling time for the retinal and choroidal circulation before and after treatments. The accuracy data was used to evaluate the effect.RESULTS: After taken Qi Ming granule for 3mo, there were significant decrease of the retina and the choroid filling time in NDR and NPDR groups. The occurrence rate of various abnormal angiographic features were significantly decreased. CONCLUSION: Qi Ming granule can accelerate the blood flow of retina and choroid, improve the blood circulation in diabetes patients, and delay the occurrence and development of diabetic retinopathy.

AIM: To evaluate the clinical therapeutic efficacy of the Qi ming granule for macular edema(ME)in diabetic patients after phacoemulsification.METHODS:In this was a prospective clinical comparison study, 57 diabetic patients(76 eyes)who underwent phacoemulsification were recruited and divided into two groups: treatment group(34 eyes)and control group(42 eyes). All the patients in treatment group were given oral administration Qi ming granule(4.5g, tid)and vitamin C(0.1g, tid)for 6mo postoperatively, while vitamin C(0.1g, tid)for the controls. General clinical examinations, including blood glucose and glycated hemoglobin, as well as comprehensive standardized ophthalmic examinations were performed. Optical coherence tomography(OCT)were used to detect macular edema incidence and measure central field retinal thickness.RESULTS: No significant difference was found in the levels of blood glucose,glycated hemoglobin, course of disease, and macular thickness between the two groups during the initial visits. At the 6th month, 2 eyes(6%)eyes had clinically apparent macular edema in treatment group, while 6(14%)eyes had clinically apparent macular edema in control group(P=0.285). The central subfield retinal thickness values were significantly lower in the treatment group(211.76±41.21μm)than those in control group(278.36±48.94μm)(PCONCLUSION:Qi ming granule can significantly reduce the incidences of macular edema and suppresses increasing retinal thickening after phacoemulsification in patients with diabetes mellitus.