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26 results on '"Qi, Hanmei"'

1. Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID)

Author

Jin, Xinyao, Pang, Bo, Zhang, Junhua, Liu, Qingquan, Yang, Zhongqi, Feng, Jihong, Liu, Xuezheng, Zhang, Lei, Wang, Baohe, Huang, Yuhong, Josephine Fauci, Alice, Ma, Yuling, Soo Lee, Myeong, Yuan, Wei'an, Xie, Yanming, Tang, Jianyuan, Gao, Rui, Du, Liang, Zhang, Shuo, Qi, Hanmei, Sun, Yu, Zheng, Wenke, Yang, Fengwen, Chua, Huizi, Wang, Keyi, Ou, Yi, Huang, Ming, Zhu, Yan, Yu, Jiajie, Tian, Jinhui, Zhao, Min, Hu, Jingqing, Yao, Chen, Li, Youping, and Zhang, Boli

Published
2020
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6. Age-Related Changes in Trabecular Bone Score and Bone Mineral Density in Chinese Men: A Cross-Sectional and Longitudinal Study

Author

Tang,Huan, Di,Wenjuan, Qi,Hanmei, Liu,Juan, Yu,Jing, Cai,Jinmei, Lai,Bing, Ding,Guoxian, Cheng,Peng, Tang,Huan, Di,Wenjuan, Qi,Hanmei, Liu,Juan, Yu,Jing, Cai,Jinmei, Lai,Bing, Ding,Guoxian, and Cheng,Peng

Abstract

Huan Tang, Wenjuan Di, Hanmei Qi, Juan Liu, Jing Yu, Jinmei Cai, Bing Lai, Guoxian Ding, Peng Cheng Department of Gerontology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaCorrespondence: Peng Cheng, Department of Gerontology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People’s Republic of China, Tel +86-25-68305171, Fax +86-25-83724440, Email cphh@sohu.comPurpose: This study was designed to explore age-related changes in trabecular bone score (TBS) and bone mineral density (BMD) in Chinese men through cross-sectional and longitudinal studies.Patients and Methods: We included adult men who had at least twice TBS and BMD examinations in our hospital between January 2013 and December 2020. All men were divided into an age subgroup per 10 years, comparing differences in baseline lumbar spine (LS) TBS and BMD at various parts between each age group and analyzing age-related changes in TBS and BMD during follow-up.Results: Baseline data showed that in men aged 36 to 85 years, BMD in the hip region showed a decreasing trend with age (P for trend < 0.01). However, TBS reached a high value around the age of 50, after which it decreased with age (P for trend = 0.03). During a mean follow-up of 3 years, the average annual change rate at TBS was − 0.17% in men aged 36 to 85 years, with the fastest decrease rate − 1.08% at 66 to 75 years (P < 0.05). The mean annual rate of change in LS BMD in different age subgroups increased with age (P for trend = 0.001). There was no significant decrease in mean annual change in BMD in hip regions.Conclusion: In men aged 36∼ 85 years, the trend of TBS was inconsistent with BMD. Men experience a high value of LS TBS around age 50, later than the commonly believed age of peak BMD, which may reflect developmental differences between bone microstructure and bone minerals. The TBS may be used as a better indicator

Published
2022

10. The correlation of muscle thickness and pennation angle assessed by ultrasound with sarcopenia in elderly Chinese community dwellers

Author

Zhu,Siping, Lin,Wei, Chen,Shu, Qi,Hanmei, Wang,Siting, Zhang,Aisen, Cai,Jinmei, Lai,Bing, Sheng,Yunlu, and Ding,Guoxian

Subjects
Male, China, Sarcopenia, Hand Strength, physical performance, Middle Aged, musculoskeletal system, pennation angle, body regions, B-mode ultrasound, Absorptiometry, Photon, muscle mass, Clinical Interventions in Aging, muscle strength, Humans, Female, Independent Living, muscle thickness, Muscle, Skeletal, Original Research, Aged, Ultrasonography
Abstract

Siping Zhu,1,* Wei Lin,1,* Shu Chen,1,* Hanmei Qi,1 Siting Wang,2 Aisen Zhang,1 Jinmei Cai,1 Bing Lai,1 Yunlu Sheng,1 Guoxian Ding11Division of Geriatric Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Division of Intensive Care Unit, Nanjing Jiangning Hospital, Nanjing, Jiangsu, People’s Republic of China*These authors contributed equally to this workBackground: Sarcopenia is typically defined as the loss of muscle mass, strength and low physical performance with aging. Ultrasound is a safe and easy method for evaluating muscle mass and quality by muscle thickness (MT) and pennation angle (PA), respectively. Although the positive correlations between MT and muscle mass and handgrip strength were observed, the relationship between MT, PA and physical performance remains unclear.Purpose: This study aimed to investigate the correlation of aforementioned ultrasound parameters with muscle mass, muscle strength and physical performance and explore the utility of ultrasound in predicting sarcopenia.Patients and methods: A total of 265 elderly Chinese community dwellers were included. MT of both forearm and lower leg as well as PA of gastrocnemius was assessed by ultrasound. Muscle mass was assessed by dual-energy X-ray absorptiometry. Muscle strength was measured by a Jamar hand dynamometer. Physical performance was assessed by the Short Physical Performance Battery (SPPB).Results: Anterior radial MT in men and regional MTs except posterior fibula in women were negatively correlated with the age. No significant correlation was observed between PA and the age in both genders. Posterior tibial MT and posterior fibula MT were positively correlated with the relative appendicular skeletal muscle mass in men and women, respectively. Anterior ulnar MT was positively correlated with grip strength in both genders. Moreover, gastrocnemius medialis PA showed a positive association with gait speed and SPPB in women but not in men.Conclusion: A combination of posterior fibula MT, anterior ulnar MT and gastrocnemius medialis PA measured by muscle ultrasound is helpful for the assessment of sarcopenia in Chinese elderly women. In addition, a combination of posterior tibial MT and anterior ulnar MT measured by muscle ultrasound is helpful for the assessment of sarcopenia in Chinese elderly men.Keywords: B-mode ultrasound, muscle thickness, pennation angle, muscle mass, muscle strength, physical performance

Published
2019

18. MiR-27b-3p Regulation in Browning of Human Visceral Adipose Related to Central Obesity.

Author

Yu, Jing, Lv, Yifan, Di, Wenjuan, Liu, Juan, Kong, Xiaocen, Sheng, Yunlu, Huang, Min, Lv, Shan, Qi, Hanmei, Gao, Mei, Liang, Hui, Kim, Sarah, Fu, Zan, Zhou, Hong, and Ding, Guoxian

Subjects
OBESITY treatment, VISCERA abnormalities, ADIPOSE tissues, GENE expression, FAT cells, RNA metabolism, COMPARATIVE studies, GENETIC techniques, RESEARCH methodology, MEDICAL cooperation, OBESITY, RESEARCH, RNA, EVALUATION research
Abstract

Objective: Given the rising prevalence of central obesity and the discovery that beige cells appear within white adipose tissue, strategies to enhance these energy-expending adipocytes or "browning" within white adipose depots have become of therapeutic interest to combat obesity and its associated disorders. This study focused on, the role of microRNA (miRNA)-27b-3p in human visceral adipose tissue (VAT) browning.Methods: Expression of miR-27b-3p and UCP1 in VAT and serum of humans was measured. MiR-27b-3p was overexpressed or suppressed in human visceral stromal fraction cells to analyze the potential role of miR-27b-3p.Results: UCP1 expression in human VAT decreased with elevated BMI and waist-hip ratio, whereas expression of miR-27b-3p was found to correlate positively with BMI and waist-hip ratio. High expression of miR-27b-3p was associated with reduced browning ability of human visceral adipocytes. Antagonism of miR-27b-3p led to the enhancement of browning ability in human visceral adipocytes.Conclusions: These findings highlight the decreased browning ability of VAT from humans with obesity and the role of miR-27b-3p in regulating browning of human visceral adipocytes. They suggest that miR-27b-3p should be further explored as a potential target for the treatment of central obesity. [ABSTRACT FROM AUTHOR]

Published
2018
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19. Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue

Author

Kong, Xiaocen, primary, Yu, Jing, additional, Bi, Jianhua, additional, Qi, Hanmei, additional, Di, Wenjuan, additional, Wu, Lin, additional, Wang, Long, additional, Zha, Juanmin, additional, Lv, Shan, additional, Zhang, Feng, additional, Li, Yan, additional, Hu, Fang, additional, Liu, Feng, additional, Zhou, Hong, additional, Liu, Juan, additional, and Ding, Guoxian, additional

Published
2014
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20. 11β-hydroxysteroid dehydrogenase type 1 selective inhibitor BVT.2733 protects osteoblasts against endogenous glucocorticoid induced dysfunction

Author

Wu, Lin, primary, Qi, Hanmei, additional, Zhong, Yi, additional, Lv, Shan, additional, Yu, Jing, additional, Liu, Juan, additional, Wang, Long, additional, Bi, Jianhua, additional, Kong, Xiaocen, additional, Di, Wenjuan, additional, Zha, Juanmin, additional, Liu, Feng, additional, and Ding, Guoxian, additional

Published
2013
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21. Essential roles of 11β-HSD1 in regulating brown adipocyte function

Author

Liu, Juan, primary, Kong, Xiaocen, additional, Wang, Long, additional, Qi, Hanmei, additional, Di, Wenjuan, additional, Zhang, Xiao, additional, Wu, Lin, additional, Chen, Xia, additional, Yu, Jing, additional, Zha, Juanmin, additional, Lv, Shan, additional, Zhang, Aisen, additional, Cheng, Peng, additional, Hu, Miao, additional, Li, Yujie, additional, Bi, Jianhua, additional, Li, Yan, additional, Hu, Fang, additional, Zhong, Yi, additional, Xu, Yong, additional, and Ding, Guoxian, additional

Published
2012
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22. BVT.2733, a Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, Attenuates Obesity and Inflammation in Diet-Induced Obese Mice

Author

Wang, Long, primary, Liu, Juan, additional, Zhang, Aisen, additional, Cheng, Peng, additional, Zhang, Xiao, additional, Lv, Shan, additional, Wu, Lin, additional, Yu, Jing, additional, Di, Wenjuan, additional, Zha, Juanmin, additional, Kong, Xiaocen, additional, Qi, Hanmei, additional, Zhong, Yi, additional, and Ding, Guoxian, additional

Published
2012
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23. Adipose tissue-targeted 11.BETA.-hydroxysteroid dehydrogenase type 1 inhibitor protects against diet-induced obesity

Author

Liu, Juan, primary, Wang, Long, additional, Zhang, Aisen, additional, Di, Wenjuan, additional, Zhang, Xiao, additional, Wu, Lin, additional, Yu, Jing, additional, Zha, Juanmin, additional, Lv, Shan, additional, Cheng, Peng, additional, Hu, Miao, additional, Li, Yujie, additional, Qi, Hanmei, additional, Ding, Guoxian, additional, and Zhong, Yi, additional

Published
2011
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25. Age-related changes of bone mineral density at various skeletal sites in Nanjing adult females.

Author

QI Hanmei, CHENG Peng, LIU Juan, CAI Jinmei, LAI Bin, and DING Guoxian

Abstract

Objective To explore the prevalence of osteoporosis in Nanjing adult females, and the changes of bone mineral density (BMD) at various skeletal sites during ageing. Methods BMD of the lumbar spine and the hip was measured using dual-energy X-ray absorptiometry in 388 adult females in Nanjing, aging from 20 to 29 years old. The secondary osteoporosis was excluded. Results The percentage of normal bone mass, osteopenia, and osteoporosis in Nanjing adult females was 33.5%, 48.5%, and 18%, respectively. In premenopausal women, the percentage was 52.7%, 47.3%, and 0, respectively. In postmenopausal women, the percentage was 12%, 49.7%, and 38.3%, respectively. There was no age-related change of BMD at all skeletal sites in females aging from 20 to 39 years. BMD of the femoral neck but not the spine and the hip decreased from age of 40 to 49 years. BMD decreased gradually at all skeletal sites from age of 50 years. The T score of BMD in the lumbar vertebrae and the femoral neck was lower than that in the total hip in femoles aging from 50 to 69 years. Conclusion The incidence of osteopenia in Nanjing young females is high, and become higher during aging. The incidence of osteoporosis is up to 38.3%. BMD of the femoral neck decreases first and is most sensitive in diagnosis of osteoporosis in females younger than 50 years old. However in females older than 50 years old, BMD of the lumbar spine and the femoral neck both decreases most obviously, and the sensitivity in diagnosis of osteoporosis are same. [ABSTRACT FROM AUTHOR]

Published
2014

26. Essential roles of 11β-HSD1 in regulating brown adipocyte function.

Author

Liu J, Kong X, Wang L, Qi H, Di W, Zhang X, Wu L, Chen X, Yu J, Zha J, Lv S, Zhang A, Cheng P, Hu M, Li Y, Bi J, Li Y, Hu F, Zhong Y, Xu Y, and Ding G

Subjects
11-beta-Hydroxysteroid Dehydrogenase Type 1 antagonists & inhibitors, 11-beta-Hydroxysteroid Dehydrogenase Type 1 genetics, Adipocytes enzymology, Adipose Tissue, Brown enzymology, Animals, Base Sequence, Blotting, Western, Cells, Cultured, DNA Primers, Gene Knockdown Techniques, Mice, Piperazines pharmacology, Real-Time Polymerase Chain Reaction, Sulfonamides pharmacology, Thiazoles pharmacology, 11-beta-Hydroxysteroid Dehydrogenase Type 1 metabolism, Adipocytes cytology, Adipose Tissue, Brown cytology
Abstract

Brown adipose tissue (BAT) increases energy expenditure and is an attractive therapeutic target for obesity. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1), an amplifier of local glucocorticoid activity, has been shown to modulate white adipose tissue (WAT) metabolism and function. In this study, we investigated the roles of 11β-HSD1 in regulating BAT function. We observed a significant increase in the expression of BAT-specific genes, including UCP1, Cidea, Cox7a1, and Cox8b, in BVT.2733 (a selective inhibitor of 11β-HSD1)-treated and 11β-HSD1-deficient primary brown adipocytes of mice. By contrast, a remarkable decrease in BAT-specific gene expression was detected in brown adipocytes when 11β-HSD1 was overexpressed, which effect was reversed by BVT.2733 treatment. Consistent with the in vitro results, expression of a range of genes related to brown fat function in high-fat diet-fed mice treated with BVT.2733. Our results indicate that 11β-HSD1 acts as a vital regulator that controls the expression of genes related to brown fat function and as such may become a potential target in preventing obesity.

Published
2013
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