41 results on '"Qayoom, Hina"'
Search Results
2. Mutant P53 modulation by cryptolepine through cell cycle arrest and apoptosis in triple negative breast cancer
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Qayoom, Hina and Mir, Manzoor A.
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- 2024
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3. Exploring SALL4 as a significant prognostic marker in breast cancer and its association with progression pathways involved in cancer genesis
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Qayoom, Hina, Bashir, Sania, Khan, Rumaisa, Hussain, Mahboob Ul, Wani, Shameema, and Mir, Manzoor A.
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- 2024
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4. Targeting tumor microenvironment using tumor-infiltrating lymphocytes as therapeutics against tumorigenesis
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Qayoom, Hina, Sofi, Shazia, and Mir, Manzoor A.
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- 2023
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5. Metronomic chemotherapy and drug repurposing: A paradigm shift in oncology
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Jan, Nusrat, Sofi, Shazia, Qayoom, Hina, Shabir, Aisha, Haq, Burhan Ul, Macha, Muzaffar A., Almilaibary, Abdullah, and Mir, Manzoor Ahmad
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- 2024
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6. Different Cyclins and Their Significance in Breast Cancer
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Mir, Manzoor Ahmad, Qayoom, Hina, and Mir, Manzoor, editor
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- 2023
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7. Introduction to Breast Cancer
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Mir, Manzoor Ahmad, Qayoom, Hina, and Mir, Manzoor, editor
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- 2023
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8. Decoding the molecular mechanism of stypoldione against breast cancer through network pharmacology and experimental validation
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Qayoom, Hina, Alshehri, Bader, Ul Haq, Burhan, Almilaibary, Abdullah, Alkhanani, Mustfa, and Ahmad Mir, Manzoor
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- 2023
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9. Targeting breast cancer stem cells through retinoids: A new hope for treatment
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Jan, Nusrat, Sofi, Shazia, Qayoom, Hina, Haq, Burhan Ul, Shabir, Aisha, and Mir, Manzoor Ahmad
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- 2023
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10. Elucidation of interleukin-19 as a therapeutic target for breast cancer by computational analysis and experimental validation
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sofi, Shazia, Jan, Nusrat, Qayoom, Hina, Alkhanani, Mustfa, Almilaibary, Abdullah, and Ahmad Mir, Manzoor
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- 2023
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11. Mechanistic elucidation of Juglanthraquinone C targeting breast Cancer: A network Pharmacology-based investigation
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Qayoom, Hina, Alkhanani, Mustfa, Almilaibary, Abdullah, Alsagaby, Suliman A., and Mir, Manzoor Ahmad
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- 2023
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12. A comprehensive analysis of notch signaling genes in breast cancer: Expression pattern and prognostic significance
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Sofi, Shazia, Qayoom, Hina, Jan, Nusrat, Khaliq, Nighat, Zahoor ul Haq Shah, Mohd, Almilaibary, Abdullah, and Mir, Manzoor Ahmad
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- 2023
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13. A network pharmacology-based investigation of brugine reveals its multi-target molecular mechanism against Breast Cancer
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Qayoom, Hina, Alkhanani, Mustfa, Almilaibary, Abdullah, Alsagaby, Suliman A., and Mir, Manzoor A.
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- 2023
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14. Proteomics: Application of next-generation proteomics in cancer research
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Mir, Manzoor Ahmad, primary, Qayoom, Hina, additional, Sofi, Shazia, additional, and Jan, Nusrat, additional
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- 2023
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15. Proteomics: A groundbreaking development in cancer biology
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Mir, Manzoor Ahmad, primary, Qayoom, Hina, additional, Sofi, Shazia, additional, and Jan, Nusrat, additional
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- 2023
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16. Immuno-onco-metabolism and Therapeutic Resistance
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Mir, Manzoor A., Aisha, Shariqa, Nisar, Safura, Qayoom, Hina, Mehraj, Umar, Macha, Muzafar Ahmad, editor, Bhat, Ajaz Ahmad, editor, and Wani, Nissar Ahmad, editor
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- 2022
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17. Cryptolepine: A naturally derived alkaloid inhibits breast cancer progression by blocking cell cycle progression and inducing apoptosis.
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Mir, Manzoor Ahmad, primary and Qayoom, Hina, additional
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- 2024
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18. Integrating Immunotherapy with Chemotherapy: A New Approach to Drug Repurposing
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Qayoom, Hina, primary, Mehraj, Umar, additional, Aisha, Shariqa, additional, Sofi, Shazia, additional, and Ahmad Mir, Manzoor, additional
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- 2022
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19. Expression patterns and therapeutic implications of CDK4 across multiple carcinomas: a molecular docking and MD simulation study
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Qayoom, Hina, Mehraj, Umar, Sofi, Shazia, Aisha, Shariqa, Almilaibary, Abdullah, Alkhanani, Mustfa, and Mir, Manzoor Ahmad
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- 2022
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20. Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors
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Sofi, Shazia, Mehraj, Umar, Qayoom, Hina, Aisha, Shariqa, Almilaibary, Abdullah, Alkhanani, Mustfa, and Mir, Manzoor Ahmad
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- 2022
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21. Role of immune system in TNBC
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Mir, Manzoor A., primary, Sofi, Shazia, additional, and Qayoom, Hina, additional
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- 2022
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22. The interplay of immunotherapy, chemotherapy, and targeted therapy in tripple negative breast cancer (TNBC)
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Mir, Manzoor A., primary, Sofi, Shazia, additional, and Qayoom, Hina, additional
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- 2022
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23. Contributors
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Mir, Manzoor A., primary, Qayoom, Hina, additional, Aisha, Shariqa, additional, Sofi, Shazia, additional, and Mehraj, Umar, additional
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- 2022
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24. Targeting biologically specific molecules in triple negative breast cancer (TNBC)
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Mir, Manzoor A., primary, Sofi, Shazia, additional, and Qayoom, Hina, additional
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- 2022
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25. Conventional adjuvant chemotherapy in combination with surgery, radiotherapy, and other specific targets
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Mir, Manzoor A., primary, Sofi, Shazia, additional, and Qayoom, Hina, additional
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- 2022
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26. Cyclin-dependent kinases in breast cancer: expression pattern and therapeutic implications
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Sofi, Shazia, Mehraj, Umar, Qayoom, Hina, Aisha, Shariqa, Asdaq, Syed Mohammad Basheeruddin, Almilaibary, Abdullah, and Mir, Manzoor A.
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- 2022
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27. Prognostic significance and targeting tumor-associated macrophages in cancer: new insights and future perspectives
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Mehraj, Umar, Qayoom, Hina, and Mir, Manzoor A.
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- 2021
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28. Exploring HMMR as a therapeutic frontier in breast cancer treatment, its interaction with various cell cycle genes, and targeting its overexpression through specific inhibitors.
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Shabir, Aisha, Qayoom, Hina, Ul Haq, Burhan, Mansoor, Adel Abo, Abdelrahim, Adil, Ahmad, Irshad, Almilabairy, Abdullah, Ahmad, Fuzail, and Mir, Manzoor Ahmad
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BREAST ,BREAST cancer ,CELL cycle ,CANCER treatment ,GENETIC overexpression ,BREAST cancer prognosis - Abstract
Among women, breast carcinoma is one of the most complex cancers, with one of the highest death rates worldwide. There have been significant improvements in treatment methods, but its early detection still remains an issue to be resolved. This study explores the multifaceted function of hyaluronan-mediated motility receptor (HMMR) in breast cancer progression. HMMR's association with key cell cycle regulators (AURKA, TPX2, and CDK1) underscores its pivotal role in cancer initiation and advancement. HMMR's involvement in microtubule assembly and cellular interactions, both extracellularly and intracellularly, provides critical insights into its contribution to cancer cell processes. Elevated HMMR expression triggered by inflammatory signals correlates with unfavorable prognosis in breast cancer and various other malignancies. Therefore, recognizing HMMR as a promising therapeutic target, the study validates the overexpression of HMMR in breast cancer and various pan cancers and its correlation with certain proteins such as AURKA, TPX2, and CDK1 through online databases. Furthermore, the pathways associated with HMMR were explored using pathway enrichment analysis, such as Gene Ontology, offering a foundation for the development of effective strategies in breast cancer treatment. The study further highlights compounds capable of inhibiting certain pathways, which, in turn, would inhibit the upregulation of HMMR in breast cancer. The results were further validated via MD simulations in addition to molecular docking to explore protein-protein/ligand interaction. Consequently, these findings imply that HMMR could play a pivotal role as a crucial oncogenic regulator, highlighting its potential as a promising target for the therapeutic intervention of breast carcinoma. [ABSTRACT FROM AUTHOR]
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- 2024
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29. Targeting p53 misfolding conundrum by stabilizing agents and their analogs in breast cancer therapy: a comprehensive computational analysis
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Haq, Burhan Ul, primary, Qayoom, Hina, additional, Sofi, Shazia, additional, Jan, Nusrat, additional, Shabir, Aisha, additional, Ahmad, Irshad, additional, Ahmad, Fuzail, additional, Almilaibary, Abdullah, additional, and Mir, Manzoor A., additional
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- 2024
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30. Therapeutic Options for Breast Cancer
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Aisha, Shariqa, primary, Qayoom, Hina, additional, Mehraj, Umar, additional, and Mir, Manzoor A., additional
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- 2021
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31. Combination Therapy with Phytochemicals in Breast Cancer
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Aisha, Shariqa, primary, Mehraj, Umar, additional, Qayoom, Hina, additional, and Manzoor A. Mir, Manzoor A. Mir, additional
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- 2021
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32. Immunotherapy and Chemotherapy in Breast Cancer
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Sofi, Shazia, primary, Mehraj, Umar, additional, Qayoom, Hina, additional, and Mir, Manzoor A., additional
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- 2021
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33. Targeting p53 misfolding conundrum by stabilizing agents and their analogs in breast cancer therapy: a comprehensive computational analysis.
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Ul Haq, Burhan, Qayoom, Hina, Sofi, Shazia, Jan, Nusrat, Shabir, Aisha, Ahmad, Irshad, Ahmad, Fuzail, Almilaibary, Abdullah, and Mir, Manzoor A.
- Subjects
BREAST ,BREAST cancer ,TRIPLE-negative breast cancer ,CANCER treatment ,STABILIZING agents ,DELAYED diagnosis - Abstract
Cancer continues to be a major global public health concern and one of the foremost causes of death. Delays in the diagnosis and cure may cause an increase in advanced stage disease and mortality. The most common cancer found in women currently is breast carcinoma. Breast carcinoma has surpassed lung carcinoma and currently represents the chief type of cancer diagnosed (2.3 million new cases, which amount to 11.7% of all cancer cases). In addition, by 2040, the incidence will increase by more than 46% as per the estimates of GLOBOCAN. Triple-negative breast cancer (TNBC) represents a highly aggressive and invasive subtype of breast cancer, characterized by rapid progression, short response time to the available treatment, and poor clinical results. Thus, it is very crucial to develop novel diagnostic tools and therapeutics with good efficacy. A majority of cancers display malfunction along the p53 pathway. Moreover, p53 not only loses its function but is also prone to misfolding and aggregation, leading to formation of amyloid aggregates as well. Research is being carried out to find ways to restore the normal action and expression of p53. Here, we have explored PhiKan-083 for its possible stabilizing effect on p53 in order to address the problem with its misfolding. Thus, examining the analogs of PhiKan-083 that have a role in p53 stability will help update our understanding of cancer progression and may expedite the progress of new anticancer treatments. We anticipate that the drug molecules and their analogs targeting p53 aggregation may be used in combination with other anticancer compounds to solve the problem with p53 aggregation. In this study, by employing ADMET analysis, the compounds were screened, and we further examined the chosen compounds with the help of molecular docking. By using databases like UALCAN, TIMER, GEPIA, and PredictProtein, we investiga [ABSTRACT FROM AUTHOR]
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- 2024
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34. A comprehensive analysis of Notch signalling genes in breast cancer: Expression pattern and prognostic significance
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Sofi, Shazia, primary, Qayoom, Hina, additional, Khaliq, Nighat, additional, Mir, Manzoor Ahmad, additional, and Shah, Mohd Zahoor ul Haq, additional
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- 2023
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35. Cryptolepine Targets TOP2A and Inhibits Tumor Cell Proliferation in Breast Cancer Cells - An In vitro and In silico Study
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Mir, Manzoor Ahmad, primary, Mehraj, Umar, additional, Qayoom, Hina, additional, Shafi, Shazia, additional, Farhana, Pzd, additional, and Asdaq, Syed Mohammed Basheeruddin, additional
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- 2022
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36. DElayed COloRectal cancer care during COVID-19 Pandemic (DECOR-19): Global perspective from an international survey
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Santoro, Giulio A., Grossi, Ugo, Murad-Regadas, Sthela, Nunoo-Mensah, Joseph W., Mellgren, Anders, Di Tanna, Gian Luca, Gallo, Gaetano, Tsang, Charles, Wexner, Steven D, LA TORRE, Filippo, Abary Ryan Rainiel, A, Philippines, Abdelwahab Khaled M, Egypt, Abellán Antonio M, Spain, Abraham Ned, Australia, Achkasov Sergey I, Russia, Adamina Michel, Switzerland, Adamo Vincenzo, Italy, Agapov Mikhail, Russia, Agarwal Amit, Usa, Aguado López Héctor, Spain, Aguilar Werner, Chile, AguilarMartínez María Del Mar AM, Spain, Aguilera Asuncion, Spain, Ahmed Jamil, Uk, Aiello Domenico, Italy, Akagi Tomonori, Japan, Akcakaya Adem, Turkey, Akhtar Khalid I, Pakistan, Akiba Ricardo, Brazil, Akrami Majid, Iran, Akyol Cihangir, Turkey, Alaamer Ohood H, Saudi Arabia, Alapati Kishore, India, Alasari Sami, Saudi Arabia, Albastaki Sara, Uae, Albergaria Diogo, Portugal, Alconchel Felipe, Spain, Alerta-Torre Andrea J, Philippines, Alex Ochsner, Switzerland, Alexander Herold, Germany, Alfaro Samuel, El Salvador, Ali Jehangir F, Pakistan, Aliyazicioglu Tolga, Turkey, Almgla Naser, South Africa, Alonsopoza Alfredo, Spain, Al-Radjid Jamiri, Philippines, Alselaim Nahar A, Saudi Arabia, Altaf Kiran K, Uk, Althebaity Rasha, Saudi Arabia, Altinel Yuksel, Turkey, Altiparmak Basak, Turkey, Altomare Donato F, Italy, Alvandipour Mina, Iran, Alvarez-Gallego Mario, Spain, Alyami Mohammad, Saudi Arabia, Amado Sandra, Portugal, Amato Antonio, Italy, Amodio Pietro M, Italy, Ana-Maria Mușină, Romania, Andrade Luis, Chile, Andreas Kohler, Switzerland, Angelini Giulio, Italy, Angenete Eva, Sweden, Annicchiarico Alfredo, Italy, Antelo Galarza Renan, Bolivia, Anwer Mariyah, Pakistan, Aparício David J, Portugal, Arciniega Jose A, Mexico, Arezzo Alberto, Italy, Argenio Giulio, Italy, Arenas Mara, Belgium, Arnaud Alves AA, France, Arredondo Jorge, Spain, Arslan Baha, Turkey, Arya Shobhit, Uk, Aselmann Heiko, Germany, Aumann Georg, Germany, Avanzolini Andrea, Italy, Avendano Rodolfo, Chile, Awedew Atalel F, Ethiopia, Ayantunde Abraham, Uk, Aycan Ilker, Turkey, Aytac Erman, Turkey, Azevedo Constança TM, Portugal, Ba Am, Iraq, Bader Fg, Germany, Baehrle Markus, Germany, Bagaglini Giulia, Italy, Balaban Vladimir, Russia, Balciscueta Zutoia, Spain, Balciscueta Izaskun, Spain, Baldazzi Gianandrea, Italy, Balik Emre, Turkey, Bandolon Robert, Philippines, Barberis Andrea, Italy, Barisic Goran I, Serbia, Barrera Alejandro, Chile, Barros Inês MSF, Portugal, Basaran Betul, Turkey, Basilio Pedro C, Brazil, Bech Flemming, Denmark, Behboo Roubik, Iran, Behboudi Behnam, Iran, Beitia Ivan E, Panama, Bellato Vittoria, Italy, Bellolio Felipe, Chile, Benli Sami, Turkey, Bernal Jc, Spain, Bernante Paolo, Italy, Berrospi Francisco E, Peru, Bertelson Noelle, Usa, Bevan Katharine, Uk, Bhama Anuradha, Usa, Bianco Francesco, Italy, Bievel Radulescu Raluca, Romania, Bintraiki Thamer, Saudi Arabia, Bisgin Tayfun, Turkey, Bislenghi Gabriele, Belgium, Blaslaina Juanluis, Spain, Bloom Itm, Uk, Boehm Gabriele, Germany, Bogoni Selene, Italy, Bohlooli Mehrdad, Iran, Bondurri Andrea, Italy, Boni Luigi, Italy, Bonomi Alessandro Michele, Italy, Booning Nitikun, Thailand, Boonpipattanapong Teeranut, Thailand, Bordeianou Liliana, Usa, Bossard Kerrie, Usa, Botelho Maria, Portugal, Boto Carlos, Portugal, Bottini Corrado, Italy, Bouchagier Konstantinos, Greece, Boutall Adam, South Africa, Bowers Dan, Usa, Bozbiyik Osman, Turkey, Brambilla Eduardo, Brazil, Brisinda Giuseppe, Italy, Brizzi Maria Pia, Italy, Brizzolari Marco, Italy, Brusciano Luigi, Italy, Bucci Luigi, Italy, Buchwald Pam, Sweden, Bugra Dursun, Turkey, Bui Andrew, Australia, Buldanlı Mehmet Zeki, Turkey, Bulut Orhan, Denmark, Cagigas Fernandez Carmen, Spain, Cai Yuankun, China, Calcerrada Alises Enrique, Spain, Caldes Pedro, Portugal, Calussi Marco, Italy, Calvo Espino Pablo, Spain, Campanelli Michela, Italy, Campbell Ken, Uk, Campennì Paola, Italy, Canda Arasemre, Turkey, Capolupo Gabriella T, Italy, Caravana Jorge, Portugal, Carballo Federico HE, Argentina, Carbone Fabio, Italy, Carcamo Leonardo C, Chile, Cardoso Paulo, Portugal, Cariati Maria, Italy, Caricato Marco, Italy, Carmona Maria, Spain, Carpelan Holmstrom Monika, Finland, Carrié Augusto J, Argentina, Carrino Francesco, Italy, Cartucho Daniel DF, Portugal, Carvalho Marcia, Portugal, Carvas João M, Portugal, Casagranda Biagio, Italy, Casimiro Carlos, Portugal, Castro Anyely, Dominican Republic, Catiwala-An Michael T, Philippines, Caushaj Philip F, Usa, Cavallo Debora, Italy, Cedermas Mariela, Argentina, Celayir Fevzi, Turkey, Celentano Valerio, Uk, Cengiz Fevzi, Turkey, Chaisomboon Nopdanai, Thailand, Chenghua Luo, China, Cherepenin Mikhail, Russia, Chessa Antonella, Italy, Chierici Andrea, France, Chok Aikyong, Singapore, Chouliaras Christos, Greece, Chowchankit Irin, Thailand, Christou Niki, France, Chun Hokyung, South Korea, Cillara Nicola, Italy, Cinza Margarida, Portugal, Cione Gianpiero, Italy, Cipe Gokhan, Turkey, Ciprian Duta, Romania, Cirocco William, Usa, Citgez Bulent, Turkey, Clark Jill E, Usa, Clementi Ilaria IC, Italy, Clerc Daniel, Switzerland, Clermonts Journal Pre-proof 39 Stefan HEM, Netherlands, Cobellis Luigi, Italy, Colak Tahsin, Turkey, Colao Garcia Laura, Spain, Colombo Francesco, Italy, Comba Andrea, Italy, Coret Franco Alba CFA, Spain, Correa Bonito Alba, Spain, Cosman Bard, Usa, Costa Susana GS, Portugal, Costa Marta RP, Portugal, Costa Pereira Joaquim, Portugal, Cózar Lozano Coral, Spain, Cravero Francesca, Italy, Creavin Ben, Ireland, Cross Katie LR, Uk, Cruz Arturo, Spain, Cui Junhui, China, Cunha Miguel F, Portugal, Curado Antonio, Portugal, D'Ugo Stefano, Italy, Dajti Irida, Albania, Dalessandro Antonio, France, Dal Monte Giorgio, Italy, Danelli Piergiorgio, Italy, Daniels Ian R, Uk, Dar Asif M, India, Davies Richard J, Uk, De Andrés Beatriz, Spain, De Angelis Marsilio, Italy, De Falco Nadia, Italy, De Luca Maurizio, Italy, De Luca Raffaele, Italy, De Nardi Paola, Italy, De Rosa Michele, Italy, De Silva Kaluthanthiri Patabanadi VR, Sri Lanka, De Simone Veronica, Italy, De Wilt Johannes HW, Netherlands, De-León-Rendón Jorge Luis, Mexico, Dean Phillip, Usa, Deangelis Nicola, France, Dedemadi Georgia, Greece, Delgadillo Xavier, Switzerland, Delgadillo Edgar, Switzerland, D’Elia Antonio, Italy, Delibegovic Samir, Bosnia and Herzegovina, Delis S, Greece, Della Porta Massimiliano, Italy, Del Rio Paolo, Italy, De Marano Gaetano, Italy, Demey Karel, Belgium, Demirli Atıcı Semra, Turkey, Denoya Paula I, Usa, Derebey Murat, Turkey, De Santis Mariangela, France, Devezas Vítor BS, Portugal, Dhaif Ali, Bahrain, Diaconescu Bogdan, Romania, Di Candido Francesca, Italy, Die Javier, Spain, Dieguez Beatriz, Spain, Dieter Hahnloser, Switzerland, Diez Alonso Manuel, Spain, Dimaren Ishmael, Philippines, Disimone Massimo, Italy, Doerner Johannes, Germany, Domingos Hugo VG, Portugal, Dominguez Rubén RD, Paraguay, Dorenbusch Michael, Usa, Doulias Triantafyllos A, Uk, Duff Sarah, Uk, Dulskas Audrius, Lithuania, Dunn Gary, Usa, Duque-Mallén Victoria, Spain, Dusek Tomas, Czech Republic, Dusitanond Navara, Thailand, Dzulkarnaen Zakaria Andee, Malaysia, Dworkin Michael, United Kingdom, Dybau Aleh, Belarus, Dziakova Jana, Spain, Dziki Lukasz, Poland, Dziki Adam, Poland, Efetov Sergey K, Russia, Eisa Mohamed, Egypt, Eisenstat Ted, Usa, El Sorogy Mohamed, Egypt, El-Hussuna Alaa, Denmark, Elfeki Hossam, Egypt, Elhussuna Alaa, Denmark, Eliasrabelo Fernanda, Brazil, Ellis Tyler, Usa, Elzalabany Tamer, Egypt, Emile Sameh H, Egypt, Emiroglu Mustafa, Turkey, Emmanuel Odet, France, Enomoto Masanobu, Japan, Epifani Angelo Gabriele, Italy, Erenler Ilknur, Turkey, Erkan Arman, Usa, Erol Timuçin, Turkey, Erturk Suphan, Turkey, Escalante Ricardo, Venezuela, Escartin Jorg, Spain, Escrevente Ricardo, Portugal, Espin-Basany Eloy, Spain, Estaire-Gomez Mercedes, Spain, Falaschi Federica, Italy, Falken Ylva, Sweden, Fantini Corrado, Italy, Fantozzi Mauricio, Argentina, Farid Asim, Usa, Farina Pablo, Argentina, Farmer Russ, Usa, Farmer Martin, Uk, Faul Eleanor M, Ireland, Favara Andrea, Italy, Febra Pedro, Portugal, Fenner Lyra Junior Humberto, Brazil, Fermani Claudio, Argentina, Fernandes Fábio FN, Portugal, Fernandes Miguel, Portugal, Ferracci Federica, Italy, Ferrara Francesco, Italy, Ferrari Giovanni, Italy, Ferrario Luca, Italy, Ferreira Rita, Portugal, Ferreira Carlos, Portugal, Ferris Jeff, Usa, Ferronetti Antonio, Italy, Fialho Guilherme L, Portugal, Fichera Alessandro, Usa, Figueiredo Odete, Portugal, Filipe Vieira Pedro JG, Portugal, Fiore Felicia, Italy, Folliero Cristina, Italy, Folstad Torbjorn, Norway, Forerotorres Alexander, Spain, Forgan Timothy R, South Africa, Franceschilli Marzia, Italy, Frizelle Frank, New Zealand, Froehner Junior Ilario, Brazil, Frois Miguel, Portugal, Frontali Alice, France, Fu Chuangang, China, Fulginiti Serena, Italy, Galiffa Giampaolo, Italy, Gallagher Hugh J, Uk, Gallardo Cristian, Chile, Galleano Raffaele, Italy, Gama Barbara, Portugal, Garcia Conde Maria, Spain, Garcia Granero Alvaro, Spain, Garcia Esther, Spain, García Sánchez Felipe, Spain, Garcia Septiem Javier, Spain, Garcia Walter, Argentina, Garcia-Urena Miguel Angel, Spain, Garmanova Tatiana N, Russia, Garofalo Thomas, Usa, Garoufalia Zoe, Greece, Garulli Gianluca, Italy, Gatti Matteo, Italy, Gecim Ethem, Turkey, Gellona Jose, Chile, Gercek Yuksel, Uk, Ghignone Federico, Italy, Gianchandani Moorjani Rajesh, Spain, Gianfrancisco James A, Usa, Giani Iacopo, Italy, Gibert Juan, Spain, Gilles Manceau, France, Gilmore Andrew, Australia, Gilsanz Carlos, Spain, Gilshtein Hayim, Usa, Girgin Behic, Turkey, Giria Joao, Portugal, Giuffrida Maria Carmela, Italy, Giuliani Antonio, Italy, Goi Gloria, Italy, Golovina Anastasiya, Russia, Gomez Rosado Juan Carlos, Spain, González Enrique, Spain, Granada Nemesio, Philippines, Grimme Frederike, Netherlands, Grobler Stephen, South Africa, Guaitoli Eleonora, Italy, Guerci Claudio, Italy, Guerra Daniel, Mexico, Guerreiro José MM, Portugal, Guido Jutten, Belgium, Gulcu Baris, Turkey, Gunay Emre, Turkey, Gundes Ebubekir, Turkey, Gurbuz Bulent, Turkey, Gurjar Shashank, Uk, Hainsworth Alison J, Uk, Hall Nigel, Uk, Hamed Hosam H, Egypt, Hammer Clare, Uk, Hannon Rob, Ireland, Harmston Christopher, New Zealand, Harran Nadine, South Africa, Hartendorp Paul, Usa, Hassan Iyad, Uae, Hassan Imran, Usa, Hawkins Alexander T, Usa, Hayssen Theresa, Usa, Hendren Samantha, Usa, Hernandez Garcia Miguel, Spain, Hershman Michael, Journal Pre-proof 40 UK, Hild Stefanie, Germany, Hilton Joanna, Uk, Hiranyakas Art, Thailand, Ho Ming, Australia, Hollington Paul, Australia, Holubar Stefan, Usa, Hompes Roel, Netherlands, Houcine Maghrebi, Tunisia, Hovsepyan Vardges, Armenia, Hul Rene, Netherlands, Hunt Louise E, Uk, Hyder Zargham, Uk, Ibrahim Aini F, Malaysia, Iglesias Gustavo, Brazil, Iesalnieks Igors, Germany, Ilkanich Andrei, Russia, Imanova Nargiz, Azerbaijan, Isik Arda, Turkey, Jayathilaka Buddika, Uk, Jimenez Virginia, Spain, Jimenez-Gomez Luis Miguel, Spain, Jitmungngan Romyen, Thailand, Joelsson Magnus, Sweden, Joshi Heman, Uk, Juloski Jovan T, Serbia, Juwid Abdallah E, Libya, Kanjanasilp Prapon, Thailand, Kannappa Lava, Uk, Kanno Danilo, Brazil, Kaplan Esin, Turkey, Kara Yasin, Turkey, Kartal Abdulcabbar, Turkey, Kawamura Junichiro, Japan, Kaya Tayfun, Turkey, Kazemi Nava Andrea, Italy, Kazachenko Ekaterina A, Russia, Kelkar Ashish, Uk, Kelly Michael E, Ireland, Keramati Mohammad Reza, Iran, Kerawala Asad, Pakistan, Khalil Mohammad I, Bangladesh, Khan Jim S, Uk, Khan Rbn, Uk, Khitaryan Alexander, Russia, Kinjo Tatsuya, Japan, Kirilova Tanya N, Bulgaria, Kirmizi Yasemin, Turkey, Klaristenfeld Daniel, Usa, Knapp Jens, Norway, Koc Mehmet A, Turkey, Kocián Petr, Czechia, Konishi Tsuyoshi, Japan, Konstantoudakis Georgios, Cyprus, Konsten Joop, Netherlands, Kontovounisios Christos, Uk, Korkmaztoker Melike, Turkey, Kørner, Hartwig, Norway, Krdzic Igor, D, Serbia, Krivokapic Zoran, Serbia, Kumar Sanjeev, India, Kumar Sandip, Malaysia, Kushtrim Shala, Germany, Kynaston James, Uk, Langmayr Johannes, Austria, La Torre Marco, Italy, La Torre Filippo, Italy, Labalde Maria, Spain, Lagopoulos Vasileios, Greece, Lal Roshan, Uk, Landaluce- Olavarria Aitor, Spain, Langone Antonio, Italy, Lapolla Pierfrancesco, Italy, Larach Sergio, Usa, Larach, Andres, Chile, Larsson, Peranders, Sweden, Lasala Alfred, Philippines, Lauretta Andrea, Italy, Leao Pedro, Portugal, Lee Pamela C, Usa, Lee Suk-Hwan, South Korea, Lee Wooyong, South Korea, Lefevre Jeremie H, France, Leite Julio, Portugal, Lemaire Julien, Belgium, Lemma Maria, Italy, Lemme Gustavo Nestor, Argentina, Lenna Giovanni, Italy, Leo Cosimo Alex, Uk, Leventoglu Sezai, Turkey, Licardie Eugenio, Spain, Lienert Mark, Germany, Lima Sergio, Brazil, Limbert Manuel CSB, Portugal, Lisi Giorgio, Italy, Litta Francesco, Italy, Littaua Dennis, Philippines, Liu Fanlong, China, Liyanage Chris, New Zealand, Llovera Antony, Cuba, Lo Oswens, China, Lo Dico Rea, France, Lobascio Pierluigi, Italy, Lohsiriwat Varut, Thailand, Lombana Luis, Colombia, Lopez Marc, Philippines, Lopez Jose, Mexico, Lopez Francisco, Chile, Lorber Julie, Usa, Losada Manuel, Spain, Lowenfeld Lea, Usa, Lucci Enrico, Italy, Luglio Gaetano, Italy, Lynch Craig, Australia, Luqman, Pakistan, Machairas Nikolaos, Uk, Maciel João MRP, Portugal, Madbouly Khaled, Egypt, Madhoun, Nisreen, Usa, Maffioli, Anna, Italy, Magbojos Christian Raymond S, Philippines, Magistro Carmelo CM, Italy, Magrino Thomas, Usa, Makhoul Rami, Usa, Mallmann Karen DP, Brazil, Manatakis Dimitrios K, Greece, Mancini Stefano, Italy, Manfredelli Simone, France, Mangione John, Usa, Manso Antonio, Portugal, Marakutsa Eugen V, Moldova, Marano Alessandra, Italy, Marchesi Federico, Italy, Marchiori Mauro, Brazil, Marfan Michael, Australia, Marianelli Raphael, Brazil, Mariani Nicolò M, Italy, Marimuthu Kalimuthu, Uk, Marinello Franco, Spain, Marinis Athanasios, Greece, Marino Marco V, Italy, Markides Georgios, Cyprus, Marquez Lucila, Spain, Marra Angelo A, Italy, Martín Navarro Fabian, Mexico, Martin-Martin Gonzalo P, Spain, Martinez Javier, Spain, Martinez-Iglesias Marta A, Uk, Martins Ruben AFP, Portugal, Martins Ana RG, Portugal, Mascali Davide DM, Italy, Massucco Paolo, Italy, Matas Fernando, Spain, Mathew Alexander, Usa, Matzel Klaus E, Germany, Maun Dipen, Usa, Maurus Christine F, Switzerland, McCormick Jim, Usa, McIntyre Robert, Uk, McKinley Aileen, Uk, McLemore Lisa, Usa, McNeil Jennifer, Usa, McNevin Shane, Usa, Medich David, Usa, Medina Cesar, Mexico, Medina Quintana Rita E, Spain, Melo Ingrid, Paraguay, Melstrom Kurt A, Usa, Mendoza-Moreno Fernando, Spain, Menna Maria Paola, Italy, Mentz Ricardo, Argentina, Merlini David A, Italy, Mihmanli Mehmet, Turkey, Mike Spencer, Usa, Millan Monica, Spain, Miller Jerad, Usa, Milone Marco, Italy, Minahi Ilyas, Uk, Minaya-Bravo Ana María, Spain, Mingoli Andrea, Italy, Minicozzi Annamaria, Uk, Miranda Pedro, Portugal, Miro Antonio, Italy, Miskovic Danilo, Uk, Mistrangelo Massimiliano, Italy, Mitra Rajarshi, Uae, Mittal Rohin, India, Mladenovikj Dragoslav P, North Macedonia, Moctezuma Velázquez Paulina, Mexico, Mohamed Kamil Nil Amri, Malaysia, Mohammed Mohammed MH, Egypt, Mohsen Yasser MA, Uk, Monami Benoit N, Belgium, Monroe Justin, Usa, Monroy Hermogenes DJ, Philippines, Montori Giulia, Italy, Montuori Mauro, Italy, Mora-Guzmán Ismael, Spain, Moraes Ana, Brazil, Morales Carlos, Usa, Morelli Luca, Italy, Moreno Almudena, Spain, Moretto Gianluigi, Italy, Morici Riccardo, Italy, Morini Andrea, Italy, Moro-Valdezate David, Spain, Moroni Eliana, Italy, Morton Dion, Uk, Moura Catarina, Portugal, Moysidis Moysis M, Greece, Mozo Ana S, Spain, Nacion Aeris Jane D, Philippines, Nada Mohamed, Journal Pre-proof 41 Egypt, Nagasaki Toshiya, Japan, Nakamoto Yoshihiko, Japan, Neary Peter, Ireland, Negoi Ionut, Romania, Neijenhuis Peter A, Niger, Ng Simon SM, China, Niazi Samiullah, Pakistan, Nikoupour Hamed, Iran, Nogueiro Jorge PM, Portugal, Noguera Jose, Spain, Nova Carlos, Portugal, Nunes Amadeu, Portugal, O'Riordain Micheal G, Ireland, Oke Olatunbosun A, Nigeria, Okkabaz Nuri, Turkey, Oliva Cristiano, Italy, Oliveira Olga, Portugal, Oliveira Manuel, Portugal, Oliveira Antonio, Portugal, Oliveira Lucia CC, Brazil, Olivier James B, Uk, Olivier Pittet, Switzerland, Omejc Mirko, Slovenia, Ong Loreto B, Philippines, Ong David, Malaysia, Onglao Mark, Philippines, Onody Peter, Hungary, Orefice Raffaele, Italy, Ortega David, Peru, Ozben Volkan, Turkey, Ozcan Onder, Turkey, Ozturk Ersin, Turkey, Pacheco Andre, Portugal, Paci Marco, France, Paczosa Marcin, Poland, Padmanabhan Anantha, Usa, Pai Ajit, India, Palmer Gabriella, Sweden, Pandey Diwakar, India, Panis Yves, France, Pantel, Haddon, Paonariang Krisada, Thailand, Papa Mario V, Italy, Papadopoulos Aristeidis, Greece, Papagni Vincenzo, Italy, Papp Andras, Sweden, Parello Angelo, Italy, Parente Alessandro, Uk, Parra Pedro, Spain, PascualMigueláñez Isabel, Spain, Pata Francesco, Italy, Patel Nikhil, Usa, Patel Reeya, Uk, Pattyn Paul RL, Belgium, Paul Bikram, Usa, Pavanello Maurizio, Italy, Pedro Luis E, Argentina, Pellino Gianluca, Spain, Peltrini Roberto, Italy, Peña Ros Emilio, Spain, Pennacchi Luca UC, Italy, Pereira André, A Portugal, Pereira Bela, Portugal, Perez Guillermo, Ecuador, Perez Horacio, Portugal, Perez Natalia, Spain, Perez Flecha Marina, Spain, Perinotti Roberto, Italy, Pernazza Graziano, Italy, Perra Teresa, Italy, Pertile Davide, Italy, Pessia Beatrice, Italy, Pessoa Joana, Brazil, Petagna Lorenzo, Italy, Peters Walter, Usa, Petit Mindy, Usa, Petracca Gabriele Luciano, Italy, Pezzolla Francesco, Italy, Philp Matthew, Usa, Pianim Nana, Usa, Picciariello Arcangelo, Italy, Piccinini Pablo E, Argentina, Piccinni Giuseppe, Italy, Piccolo Davide, Italy, Pigalarga, Rodolfo, Pikarsky Alon J, Israel, Pimentel Alice, Portugal, Pinchot Scott, Usa, Pinotti Enrico, Italy, Pinto Diogo, Portugal, Pirozzi Felice, Italy, Plastiras Aris, Greece, Platto Marco, Italy, Plerhoples Tim, Usa, Podda Mauro, Italy, Poggi Luis, Peru, Polastri Roberto, Italy, Porcu Alberto, Italy, Porter Michael, Usa, Poskus Eligijus, Lithuania, Potolicchio Analia I, Argentina, Poylin Vitaliy, Usa, Pozzo Mauro, Italy, Pramateftakis Manos, Greece, Pravosudov Igor V, Russia, Praxedes Vanessa P, Portugal, Primoromaguera Vicent, Spain, Progno Valerio C, Italy, Proud David M, Australia, Pucciarelli Salvatore, Italy, Qadir Abdul, Uk, Qayoom Hina, Pakistan, Quindos Patricia, Spain, Quintanilha Rui, Portugal, Quinteros Francisco A, Usa, Qureshi Nafees, Uk, Rachadell Juan J, Portugal, Ralf Schmidt, Germany, Raman Shankar, Usa, Ramos Diego, Spain, Ramos Jose, Portugal, Ramwell, Andrew, Randazzo, Valentina, Rattanarpichart Patsaporn, Thailand, Ratto Carlo, Italy, Rautio Tero, Finland, Raviolo Carla, Italy, Read Thomas, Usa, Real Joao, Portugal, Rega Daniela, Italy, Regadas Francisco, Brazil, Regenbogen Scott, Usa, Reia Marta, Portugal, Reina Angel, Spain, Rems Miran, Slovenia, Rencuzogullari Ahmet, Turkey, Renwick Andrew A, Uk, Reyes Juan C, Colombia, Reyes Jeryl Anne Silvia R, Philippines, Ribeiro Jr Ulysses, Brazil, Ridzuan Farouk, Singapore, Ripetti Valter, Italy, Ripoll Cristina, Mexico, Ripollés-Melchor Javier, Spain, Rizal Rizal, Indonesia, Rizk Mariam, Uk, Rizvi Irfan, Usa, Robinson Jonathan, Uk, Rodimov Sergei, Russia, Rodrigues João VL, Brazil, Rodriguez Javier, Mexico, Rodriguez Cristian, Argentina, Rodriguez Homero, Panama, Rodriguez Garcia Jaime, Mexico, Roig Jose, Spain, Rojanasakul Arun, Thailand, Rojas Julio, Chile, Romanelli Elena, France, Rosa Fausto, Italy, Rosato Guillermo, Argentina, Rosenberg Robert, Switzerland, Rosete Manuel, Portugal, Roslani April C, Malaysia, Rottoli Matteo, Italy, Roxas Manuel Francisco Roxas T, Philippines, Roxburgh Campbell S, Uk, Ruan Joseph, Usa, Rubbini Michele M, Italy, Rubio Eduardo, Spain, Ruddy Theresa, Usa, Rueda Camilo, Spain, Ruiztovar Jaime, Spain, Rusconi Andrea, Italy, Rutegård Martin, Sweden, Sá Milene RRM, Portugal, Saad Luiz Henrique Cury, Brazil, Sadien Iannish D, Uk, Sadowski Brian M, Usa, Saeed Mirza Faraz, Bahrain, Safiyeva Aynur K, Azerbaijan, Sagap Ismail, Malaysia, Sahnan Kapil, Uk, Sairafi Rami, Saudi Arabia, Saklami Avanish P, India, Salgado-Nesme Noel NSN, Mexico, Salman Nevriye, Turkey, Samalavicius Narimantas E, Lithuania, Sambucci Daniele, Italy, Sanchez Noel, Usa, Sanchez Robles Juan Carlos, Mexico, Sanmiguel Carlos, Spain, Santacruz Eduardo, Paraguay, Santoni Simone, Italy, Santos Pedro MD, Portugal, Santos Brian U, Argentina, Santos Carlos, Portugal, Sapienza Paolo, Italy, Saracoglu Ayten, Turkey, Saracoglu Kemal T, Turkey, Sardinas Carlos, Venezuela, Sari Ramazan, Turkey, Sarma Diwakar, Uk, Sartori Alberto A, Italy, Sasia Diego, Italy, Sbaih Mohammed H, Saudi Arabia, Scabini Stefano, Italy, Scaringi Stefano, Italy, Scheinin Tom M, Finland, Schiavo Marcello, Italy, Schizas Alexis, Uk, Sciaudone Guido, Italy, Scognamillo Fabrizio, Italy, Scott Kelley, Usa, Scow Jeffrey S, Usa, Sechi Raffaele, Italy, Seehra Harkiran, Uk, Segering Joerg, Germany, Selcuk Mehtap, Turkey, Journal Pre-proof 42 Selemane Carlos, Mozambique, Seltman Ann, Usa, Selvaggi Francesco, Italy, Sensi Bruno, Italy, SeowChoen Francis, Singapore, Sernagiotto Carlo, Italy, Serralta De Colsa Daniel, Spain, Serrano González Javier, Spain, Sert Ismail, Turkey, Serventi Alberto, Italy, Sforza Sergio, Italy, Shabbir Jamshed, Uk, Shabeeb Fadel, Uae, Shafik Ali, Egypt, Shalaby Mostafa, Egypt, Shanker Bethann, Usa, Shanmugam Venkatesh, Uk, Shariff Umar, Uk, Shehta Ahmed, Egypt, Shelton Andrew, Usa, Shintaro Akamoto, Japan, Shlyk Daria, Russia, Shukla Amit, Uk, Sibio Simone, Italy, Sietze Koopal, Netherlands, Sigurdardottir Johanna, Sweden, Silva Jorge, Mexico, Silva Anaisa, Portugal, Simianu Val, Usa, Singh Baljit, Uk, Siragusa Leandro, Italy, Sirikurnpiboon Siripong, Thailand, Sivrikoz Emre, Turkey, Sizonenko Nikolay, Russia, Slavchev Mihail T, Bulgaria, Sniuolis Pranas, Lithuania, Soares Duarte, Qatar, Sojar Valentin, Slovenia, Sokmen Selman, Turkey, Sokol Thomas, Usa, Soldatov Denis, Russia, Soncini Stefania, Italy, Sordo Ricardo, Mexico, Sosa María V, Spain, Sousa Xavier, Portugal, Sozutek Alper, Turkey, Spiezio Giovanni, Italy, Spinelli Antonino, Italy, Stahl Etienne, Mexico, Stanojevic Goran Z, Serbia, Steckel Brian, Usa, Stefan Neagu, Romania, Stefanescu Victor, Romania, Steinhagen Randolph, Usa, Stella Marco, Italy, Stephensen Bree D, Australia, Stevenson Andrew RL, Australia, Stitzenberg Karyn, Usa, Strombom Paul, Usa, Sturiale Alessandro, Italy, Suhail Anjum, Pakistan, Sungurtekin Ugur, Turkey, Sutton Jeffrey M, Usa, Suwannakij Chanchai, Thailand, Szczepkowski Marek, Poland, Sztipits Tamas, Hungary, Takashi Akiyoshi, Japan, Takkenberg Marijn, Netherlands, Tallon-Aguilar Luis, Spain, Tam Michael, Usa, Tamburini Andrea M, Italy, Tamini Nicolò, Italy, Tammaro Pasquale, Italy, Tan Kerkan, Singapore, Tan Teerasan, Thailand, Tanal Mert, Turkey, Tanda Cinzia, Italy, Tang Jinghua, China, Tapiolas Ingrid, Uk, Täreby Magnus, Sweden, Tariverdiev Andrey, Russia, Tayar Serkan, Turkey, Tejedor Patricia, Spain, Terrosu Giovanni, Italy, Testa Alessandro, Italy, Tewari Shirish, Uk, Thabet Waleed, Egypt, Thakur Sukesh, India, Thomas Ehmann, Germany, Thomas Kuruc, Germany, Tiesi Vincenzo, Italy, Tin Moemoetin, Myanmar, Tita Agustin C, Argentina, Titu Liviu V, Uk, Tkachenko Fedot, Ukraine, Tonello Paolo, Italy, Tooley Richard, Usa, Torres Juan, Spain, Troci Albert, Italy, Trompetto Mario, Italy, Troncoso Pereira Paula, Spain, Tropeano Francesca Paola FP, Italy, Trostchansky Ivan, Uruguay, Tsujinaka Shingo, Japan, Tufo Andrea, Italy, Tulina Inna, Russia, Turati Luca, Italy, Turchina Catalin, Sweden, Turina Matthias, Switzerland, Tutino Roberta, Italy, Tyler Km, Usa, Uemura Mamoru, Japan, Unal Ayse G, Turkey, Uraiqat Ahmad, Jordan, Uribe Sebastián, Chile, V Duke, Usa, Vailati Bruna, Brazil, Vaingurt Mariano, Argentina, Valente Michael, Usa, Van Dellen Jonathan, Uk, Van Ramshorst Gabrielle H, Belgium, Vannelli Alberto, Italy, Vanriel W, Belgium, Varabei Aliaksandr, Belarus, Varcada Massimo, Uk, Varela Cristopher L, Venezuela, Varma Madhulika G, Usa, Vasapollo Leoluca F, Italy, Venn Mary L, Uk, Vercillo Kristin, Usa, Vergara-Fernandez Omar, Mexico, Veronesi Paolo, Italy, Vicente Aline, Brazil, Victor Tomulescu, Romania, Vieiradesousa Paulo, Portugal, Vignali Andrea, Italy, Vigorita Vincenzo, Spain, Vilchis Jose, Mexico, Villaverde Kathia, Peru, Vindevoghel Koen, Belgium, Violante Tommaso, Italy, Vitoopinyoparb Kasidin, Thailand, Voutsarakis Athanasios, Uk, Wainstein Ricardo, Argentina, Wakefield Simon, Uk, Wallon Conny, Sweden, Wang Yongbing, China, Wang Xiaodong, China, Wang Xiaofeng, China, Warden Claire, South Africa, Wei Rockson, China, Wheeler Matthew, Usa, Willem Bemelman, Netherlands, Wilson Matthew, Usa, Winter Des C, Ireland, Wongwiwatseree Yongsun, Thailand, Woon Kyung Jeong, South Korea, Wright Danette B, Australia, Wu Jiong, China, Wuraola Funmilola O, Nigeria, Xenaki Sofia A, Greece, Xiaohua Jiang, China, Xiaoqiang Jia, China, Xue Yahong, China, Xynos Evangelos, Greece, Yamada Kazunosuke, Japan, Yanar Hakan, Turkey, Yang Bolin, China, Yanishev Alexey, Russia, Yildirim Ali C, Turkey, Yildiz Ufukmete, Turkey, Yildiz Alp, Turkey, Yilmaz Mehmet, Turkey, Younis Muhammad Umar MUY, Uae, Yousef Zeyad, Saudi Arabia, Yu Dongsheng, China, Zalucki James, Usa, Zaman Ahamaduz, Bangladesh, Zamora Aída T, Spain, Zampitis Nikolaos, Cyprus, Zanus Giacomo, Italy, Zapata Gonzalo H, Argentina, Zelic Marko, Croatia, Zenger Serkan, Turkey, Zheng Jianyong, China, Zigiotto Daniele, Italy, Zmora Oded, Israel, Zoikas Athanasios, Greece, Zorcolo Luigi, Italy, Zucchella Martino, Italy, Zuhdy, Mohammad, Santoro G.A., Grossi U., Murad-Regadas S., Nunoo-Mensah J.W., Mellgren A., Di Tanna G.L., Gallo G., Tsang C., Rottoli M., and Wexner S.D.
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Male ,medicine.medical_specialty ,Delayed Diagnosis ,Internationality ,Colorectal cancer ,colorectal surgery - COVID-19 - delay - treatment - outcomes ,MEDLINE ,colorectal cancer ,030230 surgery ,medicine.disease_cause ,Article ,Time-to-Treatment ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Pandemic ,medicine ,Humans ,Practice Patterns, Physicians' ,Elective surgery ,Personal protective equipment ,SARS-CoV-2 ,COVID-19 ,delayed surgery ,Coronavirus ,Infection Control ,business.industry ,Outbreak ,medicine.disease ,030220 oncology & carcinogenesis ,Preparedness ,Emergency medicine ,Female ,Surgery ,Colorectal Neoplasms ,business ,Colorectal Surgery - Abstract
Background The widespread nature of coronavirus disease 2019 (COVID-19) has been unprecedented. We sought to analyze its global impact with a survey on colorectal cancer (CRC) care during the pandemic. Methods The impact of COVID-19 on preoperative assessment, elective surgery, and postoperative management of CRC patients was explored by a 35-item survey, which was distributed worldwide to members of surgical societies with an interest in CRC care. Respondents were divided into two comparator groups: 1) ‘delay’ group: CRC care affected by the pandemic; 2) ‘no delay’ group: unaltered CRC practice. Results A total of 1,051 respondents from 84 countries completed the survey. No substantial differences in demographics were found between the ‘delay’ (745, 70.9%) and ‘no delay’ (306, 29.1%) groups. Suspension of multidisciplinary team meetings, staff members quarantined or relocated to COVID-19 units, units fully dedicated to COVID-19 care, personal protective equipment not readily available were factors significantly associated to delays in endoscopy, radiology, surgery, histopathology and prolonged chemoradiation therapy-to-surgery intervals. In the ‘delay’ group, 48.9% of respondents reported a change in the initial surgical plan and 26.3% reported a shift from elective to urgent operations. Recovery of CRC care was associated with the status of the outbreak. Practicing in COVID-free units, no change in operative slots and staff members not relocated to COVID-19 units were statistically associated with unaltered CRC care in the ‘no delay’ group, while the geographical distribution was not. Conclusions Global changes in diagnostic and therapeutic CRC practices were evident. Changes were associated with differences in health-care delivery systems, hospital’s preparedness, resources availability, and local COVID-19 prevalence rather than geographical factors. Strategic planning is required to optimize CRC care., Global changes in both diagnostic and therapeutic practices in colorectal cancer care were evident in this survey conducted to analyze the impact of COVID-19 outbreak. The importance of this finding is that changes were associated with differences in health care delivery systems, hospital’s preparedness, resources availability, and local COVID-19 prevalence rather than geographical variations.
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- 2021
37. An insight into the cancer stem cell survival pathways involved in chemoresistance in triple-negative breast cancer
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Qayoom, Hina, primary, Wani, Nissar A, additional, Alshehri, Bader, additional, and Mir, Manzoor A, additional
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- 2021
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38. Targeting Different Pathways Using Novel Combination Therapy in Triple Negative Breast Cancer
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Mir, Manzoor A., primary, Qayoom, Hina, additional, Mehraj, Umar, additional, Nisar, Safura, additional, Bhat, Basharat, additional, and Wani, Nissar A., additional
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- 2020
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- View/download PDF
39. Integrating Immunotherapy with Chemotherapy : A New Approach to Drug Repurposing
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Mir, Manzoor, Qayoom, Hina, Mehraj, Umar, Rasool, Shariqa, and Sofi, Shazia
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Medical / Nursing / Pharmacology - Abstract
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking the three hormonal receptors namely estrogen receptor, progesterone receptor and HER2 receptor, and the only treatment option available for TNBC is chemotherapy. Chemotherapy lacks specificity since it acts on normal healthy cells as well resulting into secondary diseases in TNBC patients. In addition chemotherapy poses recurrence and relapse issues due to the development of chemoresistance among TNBC patients. Immunotherapy remarkably immune checkpoint inhibitors show a great therapeutic potential in TNBC. As TNBC contain an increased TILs (tumor infiltrating lymphocytes) infiltration making it more suitable as a therapeutic target anti-tumor immune strategy. Moreover, evidences have indicated that chemotherapy upregulates the anti-tumor immune response in TNBC. As a result, a combination of immunotherapy with chemotherapy may increase the overall relapse and recurrence free survival of TNBC patients. Therefore, in this chapter we will focus on how the immunotherapy works in TNBC, their effects and consequences. We will further be discussing the clinical studies and the importance of immune checkpoint inhibitors (ICIs) in combination with various therapeutic agents and target. Further, we will explore the processes involved.
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- 2020
40. Corrigendum: Targeting p53 misfolding conundrum by stabilizing agents and their analogues in breast cancer therapy: a comprehensive computational analysis.
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Haq BU, Qayoom H, Sofi S, Jan N, Shabir A, Ahmad I, Ahmad F, Almilaibary A, and Mir MA
- Abstract
[This corrects the article DOI: 10.3389/fphar.2023.1333447.]., (Copyright © 2024 Haq, Qayoom, Sofi, Jan, Shabir, Ahmad, Ahmad, Almilaibary and Mir.)
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- 2024
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41. Cryptolepine Targets TOP2A and Inhibits Tumor Cell Proliferation in Breast Cancer Cells - An In vitro and In silico Study.
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Mehraj U, Qayoom H, Shafi S, Farhana P, Asdaq SMB, and Mir MA
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- Antigens, Neoplasm genetics, Cell Proliferation, DNA Topoisomerases, Type II genetics, DNA Topoisomerases, Type II metabolism, DNA-Binding Proteins genetics, Female, Humans, Neoplasm Recurrence, Local, Breast Neoplasms drug therapy, Breast Neoplasms genetics, Breast Neoplasms pathology, Indole Alkaloids pharmacology, Quinolines pharmacology, Topoisomerase II Inhibitors pharmacology
- Abstract
Background: DNA Topoisomerase II Alpha (TOP2A), a protein-coding gene, is central to the replication process and has been found deregulated in several malignancies, including breast cancer. Several therapeutic regimens have been developed and approved for targeting TOP2A and have prolonged the survival of cancer patients. However, due to the inherent nature of the tumor cell to evolve, the earlier positive response turns into a refractory chemoresistance in breast cancer patients., Objective: The study's main objective was to analyze the expression pattern and prognostic significance of TOP2A in breast cancer patients and screen new therapeutic molecules targeting TOP2A., Methods: We utilized an integrated bioinformatic approach to analyze the expression pattern, genetic alteration, immune association, and prognostic significance of TOP2A in breast cancer (BC) and screened natural compounds targeting TOP2A, and performed an in silico and an in vitro analysis., Results: Our study showed that TOP2A is highly overexpressed in breast cancer tissues and overexpression of TOP2A correlates with worse overall survival (OS) and relapse-free survival (RFS). Moreover, TOP2A showed a high association with tumor stroma, particularly with myeloid-derived suppressor cells. Also, in silico and in vitro analysis revealed cryptolepine as a promising natural compound targeting TOP2A., Conclusion: Cumulatively, this study signifies that TOP2A promotes breast cancer progression, and targeting TOP2A in combination with other therapeutic agents will significantly enhance the response of BC patients to therapy and reduce the development of chemoresistance., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
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- 2022
- Full Text
- View/download PDF
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