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The research provides an overview of the rise of the Zionist movement, starting from the establishment of the Jewish Colonial Society in 1891 by Maurice de Hirsch, leading to the formation of the World Zionist Organization and the creation of the Jewish National Fund in 1901. It discusses the controversial debates over the location of a Jewish homeland, including the Uganda Scheme, and the advocacy for Palestine by figures like Herzl. The impact of World War I on the Middle East was influenced by the Sykes-Picot Agreement of 1916 and the Balfour Declaration of 1917, which supported the establishment of a Jewish national home in Palestine. The British Mandate in Palestine, established after the collapse of the Ottoman Empire, had significant impacts on Jewish immigration, Arab displacement, and the road to statehood. The United Nations eventually issued a resolution in 1947 to divide Palestine into two states, one for Jews and one for Arabs. This was accepted by Jews but rejected by Arab states. Great Britain's actions towards the end of the mandate aimed to frustrate the establishment of the Jewish state envisioned by the United Nations plan. Drawing on primary and secondary sources from esteemed archives such as the British Library and personal accounts, this research seeks to elucidate the complex historical backdrop, contextualizing key decisions and conflicts that ultimately shaped the creation of the State of Israel. The analysis aims to provide nuanced insights into divergent perspectives held by Palestinians and Israelis regarding the resolution of this enduring conflict, rooted in a legacy of geopolitical manoeuvring and ideological fervour. [ABSTRACT FROM AUTHOR]

Aims: To evaluate the association between rs4680 polymorphism in the COMT gene and the vasoconstrictive effects of commonly used vasopressors., Background: Dopamine is a medication that is given intravenously to critically ill patients to help increase blood pressure. Catechol O-Methyl Transferase (COMT) breaks down dopamine and other catecholamines. There is a genetic variation in the COMT gene called rs4680 that can affect how well the enzyme works. Studies have shown that people with this genetic variation may have different blood pressure levels. However, no one has looked at how this genetic variation affects the way dopamine works to increase blood pressure., Objectives: To investigate the impact of the rs4680 polymorphism in the COMT gene on the pharmacodynamic response to dopamine., Methods: Critically ill patients administered dopamine were included following the consent of their legally acceptable representatives. Details on their demographic characteristics, diagnosis, drug-related details, changes in the heart rate, blood pressure, and urinary output were obtained. The presence of rs4680 polymorphism in the COMT gene was evaluated using a validated method., Results: One hundred and seventeen patients were recruited, and we observed a prevalence of rs4680 polymorphism in 57.3% of our critically ill patients. Those with mutant genotypes were observed with an increase in the median rate of change in mean arterial pressure (mm Hg/hour) [wild: 8.9 (-22.6 to 49.1); heterozygous mutant: 5.9 (-34.1 to 61.6); and homozygous mutant: 19.5 (-2.5 to 129.2)] and lowered urine output (ml/day) [wild: 1080 (21.4 to 5900); heterozygous mutant: 380 (23.7 to 15800); and homozygous mutant: 316.7 (5.8 to 2308.3)]., Conclusion: V158M (rs4680) polymorphism is widely prevalent in the population and was significantly associated with altered effects as observed clinically. This finding suggests valuable insights into the molecular basis of COMT function and its potential impact on neurotransmitter metabolism and related disorders. Large-scale studies delineating the effect of these polymorphisms on various vasopressors are the need of the hour., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)