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Polymer composites are gradually replacing traditional metal materials in the fields of aviation, aerospace, automotive and medicine due to their corrosion resistance, light weight and high strength. Moulding technology and organization morphology of polymer composite are key elements affecting the quality of products and their application, so a vacuum hot pressing process for graphene

The objective of this review is to provide currently available information on the relationship between the gut microbiome and cancer.In this mini-review, we explored the PubMed, EMBASE, and Google Scholar electronic databases, with regards to the searching terms "gut microbiome, cancer, intestinal flora, immunotherapy, immune checkpoint inhibitor". By reviewing and analyzing the literature, we analyzed how the bacterial microbiome influences the immune system and cancer, as well as how changes in symbiotic flora may be applied to improve the efficacy of cancer immunotherapy.The microbiota is related to the development of tumors and may promote canceration. In recent years, a number of studies have confirmed the influence of intestinal flora on immune checkpoint inhibitors in cancer patients, and studies have also shown the link between the intestinal microbiome and treatment-related immune toxicity. Antibiotics, proton pump inhibitors, and hormones affect the composition of the gut microbiota.Intestinal flora is closely related to cancer. Intestinal flora has a certain impact on cancer occurrence, cancer treatment, cancer immunotherapy efficacy, and side effects.

In the design of absorbing materials, investigating the ideal value range of electromagnetic parameters under given conditions and adjusting the electromagnetic parameters by existing materials to achieve the ideal range need are two important issues to be solved. Based on transmission line theory and Debye theory, numerical simulations are used to explore the ideal value range of various parameters of absorbing materials under different conditions as well as their selection laws. The Cole-Cole diagram based on combining theory and experiments was given for optimizing design of absorption performance. When the thickness and reflection attenuation rate of the material are presupposed, the real and imaginary parts of the corresponding ideal permittivity should form an approximately elliptic curve. When the permittivity of the material is in the elliptical region, the reflection attenuation rate is lower than its given value. Ellipses with lower reflection attenuation locate in ellipses with higher reflection attenuation, but the centers of the ellipses do not coincide. As the reflection attenuation rate decreases, the corresponding ellipse area shrinks sharply, and the range of electromagnetic parameters becomes rigorous.

Oil–gas separation is a key process in an aero-engine lubrication system. This study reports an innovative development in oil–gas separation. A honeycomb-structured rotor with hexagonal cone-shaped pore channels has been designed, additively manufactured from Ti-6Al-4V using selective electron beam melting (SEBM) and assessed for oil–gas separation for aero-engine application. The Ti-6Al-4V honeycomb structure showed a high compressive strength of 110 MPa compared to less than 20 MPa for metal foam structures. The oil–gas separation efficiency of the honeycomb-structured separation rotor achieved 99.8% at the rotation speed of 6000 rpm with much lower ventilation resistance (17.3 kPa) than that of the separator rotor constructed using a Ni-Cr alloy foam structure (23.5 kPa). The honeycomb-structured Ti-6Al-4V separator rotor produced by SEBM provides a promising solution to more efficient oil–gas separation in the aero-engine lubrication system.

MiR-381-3p plays an essential role in the progression of a variety of cancers, but its expression and role in papillary thyroid carcinoma (PTC) progression have not been investigated. The aim of this study was to investigate the expression of miR-381-3p and its function in PTC.The expression levels of miR-381-3p and low-density lipoprotein receptor‑related protein 6 (LRP6) mRNA in PTC tissues and cell lines were measured using RT-PCR. Cell proliferation, migration and invasion were assessed by cell viability assay and transwell assay. Luciferase assays and Western blotting were performed to demonstrate miR-381-3p target gene.We found that miR-381-3p was significantly down-regulated in PTC tissues and cell lines. In vitro assay indicated that up-regulation of miR-381-3p significantly suppressed PTC cell proliferation, migration and invasion. Moreover, luciferase reporter gene assay demonstrated that miR-381-3p could target LRP6 by binding to the 3' UTR. Western blot and Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) showed that miR-381-3p overexpression suppressed the expression of LRP6 at both mRNA and proteins levels. In addition, functional experiment confirmed that LRP6 was involved in the suppressive effect of miR-381-3p-mediated PTC on cell proliferation, migration and invasion.Our findings suggested, for the first time, that miR-381-3p was lowly expressed in PTC tissues, and its up-regulation inhibited tumorigenesis of PTC by targeting LRP6.

1. Mutations in growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are significantly associated with reproductive performance in mammals and the objective of the present study was to identify polymorphic sites and elucidate the association between genotypes in BMP15 and GDF9 and egg production. 2. Polymorphisms in BMP15 exon1 and GDF9 exon2 were detected by DNA sequencing and PCR-RFLP. Three SNPs were detected in each of BMP15 (A111G, C231T and C34T) and GDF9 (G593A, T824C and C896T). C34T leads to the substitution of Leu by Phe, which was predicted to affect protein function. 3. Results of the association analysis indicated that C34T had an effect on total egg production at 300 d of age (EN) and age at first laying (AFE). G593A affected EN and both C231T and C896T influenced AFE. The TGC1TGC1 diplotype in BMP15 had the highest EN. 4. In conclusion, EN may be significantly improved by marker-assisted selection of the BMP15 genotypes in maternal lines of Shaobo hens.

Free radicals are the intermediates of metabolism, widely exist in the human bodies. Under normal circumstances, the free radicals play an important role in the metabolic process on human body, cell signal pathway, gene regulation, induction of cell proliferation and apoptosis, so as to maintain the normal growth and development of human body and to inhibit the growth of bacteria, virus and cancer. However, when organic lesion occurs affected by external factors or when equilibrium of the free radicals is tipped in the human body, the free radicals will respond integratedly with lipids, protein or nucleic acid which may jeopardize the health of human bodies. This paper summarizes the research progress of the free radicals conducted in recent years, in relations to the perspective of the types, origins, test methods of the free radicals and their relationship with human's health. In addition, the possible mechanisms of environmental pollutants (such as polycyclic aromatic hydrocarbons) mediating oxidative stress and free radicals scavenging in the body were also summarized.

Sex-linked dwarf (SLD) chickens have been widely used in cross breeding of broilers and laying hens. To study the molecular mechanisms underlying growth hormone receptor (GHR) in SLD chickens, the expression profiles of GHR were measured in three growth related tissues (liver, breast, and thigh) in male and female S2 SLD chickens at seven growth stages (1 day, 3 weeks, 7 weeks, 9 weeks, 11 weeks, 13 weeks, and 15 weeks). Growth curves of body weight were fitted using logistic and Gompertz models. The results show that the inflexion week and inflexion weight in male chickens was earlier than in female chickens. Regarding the expression profiles of GHR, there was no significant difference between tissues at hatching. The expression peaked at 7 weeks and dropped by degrees in muscle tissue; hepatic expression increased with age and was positively correlated with body weight. Taken together, these results would provide a basis for further study on the molecular mechanisms underlying GHR regulation in SLD chickens.

For the restriction application, the uniformity of pore size and connectivity of pore channels are much more important for TiAl restrictor. TiAl porous materials have expansion phenomenon during reaction sintering for the Kirkendall Effect, and the pores were generated by its partial diffusion. In this paper, elemental powders blending and reaction sintering methods were adopted to prepare TiAl porous flow restrictor materials. The influence of particle size, the fraction of Ti and Al powder, pressing pressure, sintering temperature on the pore character of TiAl porous flow restrictor was studied. The results show that the maximum pore size and expansion coefficient increased with the increase of Al powder particle size, the porosity and permeability increased only when the Al powder particle size is larger than 400/+600 mesh. With the decrease of larger particle Al powder fraction, the porosity and permeability decreased, but the maximum pore size shows little change. With the increase of fraction of fine Al powder, the porosity and permeability increased to a certain value then decreased. With the increase of pressing pressure, maximum pore size, porosity and permeability decreased. When the sintering temperature is lower than 800C, the porosity and permeability increased with the increase of sintering temperature. At above 800C, the porosity and permeability decreased with the increase of sintering temperature. [doi:10.2320/matertrans.M2009120] (Received April 6, 2009; Accepted July 23, 2009; Published September 25, 2009)

IT Autopilot is a flexible architecture to support the delivery of information technology (IT) systems management services. Complex services that involve several tools require integration between the tools and automated processes that can invoke multiple tools. Designed primarily for the small and mid-sized enterprise, the architecture of IT Autopilot allows it to be deployed as a set of local and remote services delivered by the enterprise or by service providers as a flexible and extensible service offering. The IT Autopilot integrated IT service management platform is able to combine different tools and services to create specific, customized IT service solutions. Using the analogy of an autopilot on an airplane, the pilot first performs a set of manual operations to get the airplane off the ground and flying. Next, the autopilot is engaged to carry on normal flight operations. In our vision, there is an initial manual configuration step before IT Autopilot is enabled to take over and maintain the customer's normal IT operational state. In this paper we explain our vision and describe the prototype system we have implemented.

The algorithm to transform from 3D Cartesian to geodetic coordinates is obtained by solving the equation of the Lagrange parameter. Numerical experiments show that geodetic height can be recovered to 0.5 mm precision over the range from −6×106 to 1010 m.

The structure and the nano-friction behaviour of a new kind of ultrathin film, a molecular deposition (MD) film, on an Au substrate were studied. The MD film is formed by the electrostatic attraction between opposite charges of cationic and anionic compounds, and a multilayer film can be built through alternating deposition of bipolar cationic and anionic compounds. Monolayer, bilayer, trilayer, and tetralayer MD films on Au substrates were examined. MD films with an alkyl terminal group were also investigated. It was found that while the MD film on an Au substrate reduced the friction, its nano-friction behaviour was unstable because of the active terminal group. However, if the MD film was formed with an alkyl terminal group, its nano-friction behaviour became stable and its friction decreased markedly. Therefore, this film termination method could contribute to the nano-tribological application of MD films.

The theory of the steel-plastic geogrid employed in supporting engineering is behind the practice, seriously affecting its popularization and application in engineering. Thus the tensile strength and deflection of steel-plastic geogrid and its control of surrounding rock deformations were studied and analyzed using laboratory and engineering field tests. We have contrasted the tensile strength of steel-plastic geogrid to that of metal mesh. We have also contrasted the deflection deformation of the steel-plastic geogrid concrete slabs to that of the mesh concrete slabs. In the tensile strength test, we have tested the tensile properties of three different types of steel-plastic geogrid. In the defection deformation test, two kinds of steel-plastic geogrid concrete slabs and the mesh concrete slabs are made to investigate the load and displacement they bear. By combining with the experimental application of the Wohu Mountain iron mine, we summarized the process of steel-plastic geogrid construction and monitored the surrounding rock deformation of test section. Thus, we drew the following conclusions: (1) the tensile strength of the steel-plastic geogrid was greater than metal mesh; (2) compared with metal mesh concrete slabs, steel plastic grille with concrete slab had a larger deflection and its stress tolerance ability was better; (3) the use of the steel-plastic geogrid supporting in roadway can control the deformation of its bottom and sidewalls.

An improved adsorption model for adsorption refrigeration pairs such as activated carbon-methanol and zeolite-water is suggested based upon normal Dubinin adsorption equations. This model has been verified by various experimental results.

Restoring walking functions will greatly improve the foot-drop patients' life quality. In this work, we sampled 10 healthy subjects' gait data when walking in 4 different stride frequency overground and developed a dynamic Functional Electrical Stimulation (dFES) system for foot-drop patients' walk training, using the processed tibialis anterior (TA) muscle EMG signal. The data sampled under the new strategy can be used by FES system directly. And the dFES system can provide dynamic Pulse Width Modulation (PWM) FES serial according to the healthy subjects' TA EMG intensity features.

Two novel chiral stationary phases for ligand exchange chromatography were prepared by synthesizing 2-(2-hydroxyl-3-octoxy)propyl-(S)-1, 2, 3, 4-tetrahydro-3-isoquinolinecarboxylic acid (C8-(S)-THIQCA) and 2-(2-hydroxyl-3-dodecoxy)propyl-(S)-1, 2, 3, 4-tetrahydro-3-isoquinolinecarboxylic acid (C12-(S)-THIQCA) as chiral selectors, and coating them on ODS bonded stationary phase. Chromatographic resolutions of some DL-amino acids were achieved on the chiral stationary phases by using 1 mmol/L NH4Cl with 0.2 mmol/L Cu(Ac)2 solution as mobile phase and detection at 254 nm. Ability of chiral resolution of the DL-amino acids through the stationary phases was compared and the effect of cupric ion on resolutions of the DL-amino acids was examined. The elution order of D-isomer before L-isomer was observed for all the DL-amino acids resolved, except DL-Val. For DL-Pro, DL-Val and DL-Leu the elution order through the chiral phases was different from that through the chiral ligand exchange phases prepared from L-Pro or L-hydroxyl proline with five membered ring structure.

Sequence of MSP1-31 of Plasmodium falciparum was constructed into eukaryotic expression vector pTRE, which could be repressed by tetracycline (Tc) and resulted in recombinant plasmid pTRE-31. The plasmid was injected into the quadriceps muscle of BALB/c mice with Tc responsive plasmid pTet-off to measure specific antibodies. The MSP1-31 prokaryotic expressed protein was used as antigen in ELISA. Results showed that mice orally administered by Tc had a seroconversion rate of 7.1% (1/14) 4 weeks after injection, whereas the control mice had a seroconversion rate of 100% and the titers of antibody were raised continusly within 12 weeks. The study suggested that the recombinant plasmids pTRE-31/pTet-off could efficiently induce humoral response against MSP1-31 of malaria. Moreover this immune response was controlled by Tc and was reversible after withdrawal of Tc dilivery. The induction of antibody by removing Tc at the fourth week after injection indicated that DNA vaccine could remain in mice and capable of expressing antigen for at least 4 weeks.

In this paper the functions of helper T(Th) cell subsets, their cross regulation and agents affected their differentiation, as well as the role of Th subsets in the possible pathogenesis of autoimmune diseases were reviewed. Furthermore, a lot of opinions on autoimmune diseases therapy through restoration of Th subsets balance were mentioned. The available measurements to be used include up-regulation of CD1d, administration of relative cytokines, administration of Freund adjuvant, administration of monoclonal antibodies against cytokines, cytokine receptors, CD40 ligand or B7 molecule, as well as CTLA or CTLAIg pathway and so on.

We have studied the RFLPs distribution and frequency of dystrophin gene in Chinese by using 14 subclones of complete 14 kb cDNA for the dystrophin gene as hybridization probes. Allelic fragments are detected in hybridization patterns of Pvu II/1a, Taq I/2b-3, Taq I/5b-7, Xba I/10. Among them, the allelic fragments (26 kb and 3.8 kb) in Pvu II/2b-3 patterns and the allelic fragments (10 kb and 8.4 kb) in Taq I/5b-7 patterns are the new RFLPs which have never been reported. From the comparison of our data with those of Caucasian and Japanese respectively and their statistical analysis, we can obtain the results as follows: There is remarkable difference (p less than 0.01) of the allelic fragment frequency in Taq I/2 b-3 (A1 = 3.4 kb, fre. 0.04; A2 = 3.2 kb, fre. 0.96) and Xba I/10 (A1 = 7.4 kb, fre. 0.41; A2 = 6.7 kb, fre. 0.59) between Chinese and Caucasian. The frequency of the allelic fragments A2 in Taq I/8 (A1 = 6.5 kb, A2 = 5.6 kb) and EcoR V/9 (A1 = 11.8 kb, A2 = 10.7 kb) are high in Caucasian, but have not been detected in Chinese. These differences are also highly significant. But the B1B2 allelic frequencies in Taq I/5 b-7 (B1 = 3.2 kb, B2 = 1.6 kb) are the same. There is no significant difference in the frequency of the allelic fragments A1A2 and B1B2 in Pvu II/1 a between Chinese and Japanese. Preliminary results suggest that there probably are high frequencies for spontaneous neutral mutations in the evolution process of the huge dystrophin gene (about 2,300 kb). In the meantime, the neutral mutation frequencies of various sectional sequences have remarkable differences, and that of some sectional sequences of the gene between Chinese and Caucasian may also have remarkable differences.

A series of 122 phase BaFe$_{2-x}$Ni$_x$As$_2$ ($x$ = 0, 0.055, 0.096, 0.18, 0.23) single crystals were grown by self flux method and a dome-like Ni doping dependence of superconducting transition temperature is discovered. The transition temperature $T_c^{on}$ reaches a maximum of 20.5 K at $x$ = 0.096, and it drops to below 4 K as $x$ $\geq$ 0.23. The negative thermopower in the normal state indicates that electron-like charge carrier indeed dominates in this system. This Ni-doped system provides another example of superconductivity induced by electron doping in the 122 phase.

11 cases of idiopathic unilateral hyperlucent lung were reported: The clinical pictures and X-ray findings were analysed. The main X-ray changes were abnormal hyperlucency of the affected lung or lobe while the size of the hyperlucent lung was normal or smaller than the contralateral side. The hilar shadow and vascular markings fine and decreased During respiration, the volume of the affected lung remained constant but the mediastinum shifted to the affected side on inspiration and away from it on expiration. The affected lung retained its radiolucency on expiration. The broncho-pulmonary angiogram, lung CT scan and pulmonary vascular tomograph were studied. The clinical pictures, etiology, pathology, X-ray diagnosis and differential diagnosis were discussed.