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Fil: Funes, José Gabriel. Universidad Católica de Córdoba. Facultad de Filosofía y Humanidades; Argentina

Objective: To describe some cardiorespiratory effects of an inspiratory-to-expiratory (IE) ratio of 1:1 compared with 1:3 in ventilated horses in dorsal recumbency. Study design: Randomized crossover experimental study. Animals: A total of eight anesthetized horses, with 444 (330–485) kg body weight [median (range)]. Methods: Horses were ventilated in dorsal recumbency with a tidal volume of 15 mL kg–1 and a respiratory rate of 8 breaths minute–1, and IE ratios of 1:1 (IE1:1) and 1:3 (IE1:3) in random order, each for 25 minutes after applying a recruitment maneuver. Spirometry, arterial blood gases and dobutamine requirements were recorded in all horses during each treatment. Electrical impedance tomography (EIT) data were recorded in four horses and used to generate functional EIT variables including regional ventilation delay index (RVD), a measure of speed of lung inflation, and end-expiratory lung impedance (EELI), an indicator of functional residual capacity (FRC). Results were assessed with linear and generalized linear mixed models. Results: Compared with treatment IE1:3, horses ventilated with treatment IE1:1 had higher mean airway pressures and respiratory system compliance (p < 0.014), while peak, end-inspiratory and driving airway pressures were lower (p < 0.001). No differences in arterial oxygenation or dobutamine requirements were observed. PaCO2 was lower in treatment IE1:1 (p = 0.039). Treatment IE1:1 resulted in lower RVD (p < 0.002) and higher EELI (p = 0.023) than treatment IE1:3. Conclusions and clinical relevance: These results suggest that IE1:1 improved respiratory system mechanics and alveolar ventilation compared with IE1:3, whereas oxygenation and dobutamine requirements were unchanged, although differences were small. In the four horses where EIT was evaluated, IE1:1 led to a faster inflation rate of the lung, possibly the result of increased FRC. The clinical relevance of these findings needs to be further investigated., Fil: Pittman, Ella. Cornell University. College of Veterinary Medicine. Department of Clinical Sciences; Estados Unidos, Fil: Martin-Flores, Manuel. Cornell University. College of Veterinary Medicine. Department of Clinical Sciences; Estados Unidos, Fil: Mosing, Martina. Murdoch University. School of Veterinary Medicine; Australia, Fil: Lorenzutti, Matias. Universidad Católica de Córdoba. Facultad de Ciencias Veterinarias. Pharmacology and Toxicology; Argentina, Fil: Retamal, Jaime. Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Medicina Intensiva; Chile, Fil: Staffieri, Francesco. “Aldo Moro” University of Bari. Department of Emergency and Organ Transplantation D.E.O.T. Section of Veterinary Clinics and Animal Production; Italia, Fil: Adler, Andy. Carleton University. Systems and Computer Engineering; Canada, Fil: Campbell, Mark. Systems and Computer Engineering; Canada, Fil: Araos, Joaquin. Cornell University. College of Veterinary Medicine. Department of Clinical Sciences; Estados Unidos

Acyline contraception has been described in cats, but few data are available on the drug's long-term effect on growth. The relevant data cover until puberty with no radiographic description. We investigated the radiographic parameters throughout bone growth in order to more completely determine the drug's safety. Thirteen male and 12 female cats were studied, with the kittens being randomly assigned to one of the following groups within the first 24 hours of birth: ACY, subcutaneous acyline, 33 µg/100 g, which injection was repeated weekly until age 3 months; or CO, untreated control. Body measurements were recorded weekly and radiographic parameters obtained from monthly radiographs of the antebrachium. In the ACY and CO male and female kittens, the body weight, withers height, and body length plus the age at the end of body growth and radial growth remained similar throughout the study (P> .05). Both female groups finished radial growth before the males (P< .05). The ACY females evidenced a longer radial length between the eighth and 28th weeks (P< .05). All groups closed their proximal and distal physes within the normal ranges described for the species. The bone-cortex width was lower in the ACY vs. the CO animals at weeks 52 and 60 in the males and at weeks 24, 48, 52, and 56 in the females (P< .05) The transient greater radial length and lower bone-cortex thickness observed in the treated cats were compensated for at the end of growth with no adverse clinical effects being observed. In conclusion, acyline as a contraceptive did not evidence a permanent or severe effect on domestic-cat growth., Fil: Romero, Mariela Grisolia. CONICET; Argentina, Fil: Marchetti, Cynthia. CONICET; Argentina, Fil: Priotto, Marcelo. Universidad Católica de Córdoba; Argentina, Fil: Rodríguez, Marcelo. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina, Fil: Gobello, Cristina. CONICET; Argentina, Fil: Furlan, Paulina. Universidad Católica de Córdoba; Argentina, Fil: Faya, Marcela. Universidad Católica de Córdoba; Argentina, Fil: Romero, Mariela Grisolia. Universidad Católica de Córdoba; Argentina, Fil: Marchetti, Cynthia. Universidad Católica de Córdoba; Argentina, Fil: Gobello, Cristina. Universidad Nacional de La Plata; Argentina

Northern corn leaf blight (NCLB), caused by Exserohilum turcicum (E. turcicum), is one of the most common maize (Zea mays L.) diseases worldwide. To determine the crop damage and economic losses caused by NCLB and propose economic damage thresholds (EDTs), 16 field experiments were performed for seven crop seasons (2010–11 to 2016–17) during different naturally occurring outbreaks of NCLB in central-northern Córdoba province, Argentina. NCLB severity gradients were generated by applying different fungicides and doses at different growth stages to seven susceptible (S) and nine moderately susceptible (MS) hybrids. Plots were arranged in a completely randomized block design with four replications. Severity was evaluated at the R4 growth stage by estimating the percentage of leaves affected; and grain yield in kg ha−1 per plot was also estimated. A critical-point yield model was fitted with NCLB severity and the EDT and the action damage threshold (ADT) were calculated. The management regime generated disease gradients with severities ranging between 3.2 and 33.1. There was a statistically significant negative correlation between severity and yield (R2 = 0.52; p = 0.001). On average, for each percentage point increase, in NCLB severity, 20.15 kg t−1 of yield were lost; MS and S hybrids were 23.88 kg t−1 and 15.21 kg t−1, respectively. The mean EDT was 1.09% of severity and the mean ADT was 0.88%. Furthermore, the mean economic losses were 243.6 USD ha−1 [122.0–353.2]. The generated information can play a role in optimizing the use of fungicides for NCLB control, reducing disease control costs, and protecting the ecological environment of farmlands., Fil: De Rossi, Roberto Luis. Universidad Católica de Córdoba; Argentina, Fil: Guerra, F.A. Universidad Católica de Córdoba; Argentina, Fil: Guerra, F.A. Conicet; Argentina, Fil: Plazas M.C. Universidad Católica de Córdoba; Argentina, Fil: Vuletic, E.E. Universidad Católica de Córdoba; Argentina, Fil: Vuletic, E.E. Conicet; Argentina, Fil: Brücher, E. Universidad Católica de Córdoba; Argentina, Fil: Brücher, E. Conicet; Argentina

We present the draft genome sequence of Gordonia sp. strain Campus, which was extracted from diesel-contaminated soil in Córdoba, Argentina. It was observed that this strain, in conjunction with alfalfa and poplar, has the ability to decompose diesel-contaminated soils. The data may be important for the phytoremediation of hydrocarbon-contaminated soils., Fil: Badariotti, Esteban H. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina, Fil: Beyrne, Eduardo. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina, Fil: Tejerina, Magdalena. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Unidad Asociada al CONICET: Área de Ciencias Agrarias, Ingeniería, Ciencias Biológicas; Argentina, Fil: Raymond, María L. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Unidad Asociada al CONICET: Área de Ciencias Agrarias, Ingeniería, Ciencias Biológicas; Argentina, Fil: Soria, Néstor W. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Unidad Asociada al CONICET: Área de Ciencias Agrarias, Ingeniería, Ciencias Biológicas; Argentina

Thecaphora frezii is a phytopathogenic fungus belonging to the Ustilaginomycetes class, which causes peanut smut disease. In its biological cycle it has three structures, teliospores (is the resistance structure), basidiospores and hyphae. The mycelium is the structure that penetrates the plant’s gynophore and initiates the infection. For this action, the expression of effectors, pathogenicity and virulence factor proteins is necessary. The aim of this study was to identify potential Thecaphora frezii’s proteins that could exert pathogenicity, virulence and/or effector functions. Based on the transcriptome of two ontogenetic stages (teliospore and hyphae) of Thecaphora frezii, and a series of bioinformatic analyses, 18 potential effectors and 91 factors possibly involved in the level of pathogenicity and virulence were identified. Higher expression levels of candidate effectors were found in the infective stage of the fungus. In the other hand, the major variability observed in pathogenicity and virulence factors expressed between Ustilago maydis and Thecaphora frezii were the number of virulence factors secreted (higher in U. maydis). In the future, when the genome of the fungus will be known, functional studies of these proteins could be carried out to validate their function., Fil: Soria, Néstor W. Universidad Católica de Córdoba. Unidad Asociada al CONICET: Área de Cs. Agrarias, Ingeniería, Cs. Biológicas; Argentina, Fil: Badariotti, Esteban H. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina, Fil: Alasino, Valeria R. CEPROCOR; Argentina, Fil: Alasino, Valeria R. CONICET; Argentina, Fil: Figueroa, Ana C. CONICET; Argentina, Fil: Díaz, María S. CONICET; Argentina, Fil: Yang, Pablo. Universidad Católica de Córdoba. Unidad Asociada al CONICET: Área de Cs. Agrarias, Ingeniería, Cs. Biológicas; Argentina, Fil: Beltramo, Dante M. Universidad Católica de Córdoba. Unidad Asociada al CONICET: Área de Cs. Agrarias, Ingeniería, Cs. Biológicas; Argentina, Fil: Beltramo, Dante M. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina, Fil: Beltramo, Dante M. CEPROCOR; Argentina, Fil: Soria, Néstor W. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina, Fil: Yang, Pablo. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina, Fil: Beltramo, Dante M. CONICET; Argentina

Background: Plant miRNAs are a class of small non-coding RNAs that can repress gene expression at the post-transcriptional level by targeting RNA degradation or promoting translational repression. There is increasing evidence that some miRNAs can derive from a group of non-autonomous class II transposable elements called Miniature Inverted-repeat Transposable Elements (MITEs). Results: We used public small RNA and degradome libraries from Triticum aestivum to screen for microRNAs production and predict their cleavage target sites. In parallel, we also created a comprehensive wheat MITE database by identifying novel elements and compiling known ones. When comparing both data sets, we found high homology between MITEs and 14% of all the miRNAs production sites detected. Furthermore, we show that MITE-derived miRNAs have preference for targeting degradation sites with MITE insertions in the 3’ UTR regions of the transcripts. Conclusions: Our results revealed that MITE-derived miRNAs can underlay the origin of some miRNAs and potentially shape a regulatory gene network. Since MITEs are found in millions of insertions in the wheat genome and are closely linked to genic regions, this kind of regulatory network could have a significant impact on the post-transcriptional control of gene expression., Fil: Crescente, Juan M. CONICET; Argentina, Fil: Zavallo, Diego. CONICET. INTA. Instituto de Agrobiotecnología y Biología Molecular (IABIMO), CICVyA; Argentina, Fil: del Vas, Mariana. CONICET. INTA. Instituto de Agrobiotecnología y Biología Molecular (IABIMO), CICVyA; Argentina, Fil: Asurmendi, Sebastián. CONICET. INTA. Instituto de Agrobiotecnología y Biología Molecular (IABIMO), CICVyA; Argentina, Fil: Helguera, Marcelo. EEA INTA; Argentina, Fil: Fernandez, Elmer. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas (CIDIE-CONICET); Argentina, Fil: Fernandez, Elmer. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina, Fil: Vanzetti, Leonardo S. CONICET; Argentina, Fil: Vanzetti, Leonardo S. EEA INTA; Argentina

OBJECTIVE To compare the thermoregulatory and analgesic effects of high-dose buprenorphine versus morphine in cats undergoing ovariohysterectomy. ANIMALS 94 client-owned cats. PROCEDURES Cats were randomized to receive either buprenorphine 0.24 mg/kg or morphine 0.1 mg/kg subcutaneously (SC) during recovery from ovariohysterectomy. Body temperature measurements were obtained before anesthesia, during anesthesia (averaged), at extubation, and 2, 4, and 16 to 20 hours postoperatively. Signs of pain were assessed, and demographic characteristics were compared between groups. The effects of treatment and time on body temperature, point prevalence of hyperthermia (> 39.2 °C), and pain scores were compared with linear or generalized mixed-effect models. RESULTS Cats receiving morphine (vs. buprenorphine) were older and heavier (both, P ≤ 0.005). Other group characteristics did not differ between treatments. Cats receiving buprenorphine (vs. morphine) had higher postoperative temperatures (P = 0.03). At 2, 4, and 16 to 20 hours after extubation, the point prevalence of hyperthermia was greater (P = 0.001) for cats receiving buprenorphine (55% [26/47], 44% [21/47], and 62% [27/43], respectively) versus morphine (28% [13/46], 13% [6/46], and 47% [21/44], respectively). There were no differences in pain scores between groups or over time. Five cats receiving buprenorphine and 6 receiving morphine required rescue analgesia within the 24-hour period. CLINICAL RELEVANCE Administration of buprenorphine (0.24 mg/kg SC), compared with morphine (0.1 mg/kg SC), resulted in higher body temperatures without an apparent advantage with regard to analgesia during the first 20 postoperative hours than morphine. Opioid-induced postoperative hyperthermia could confound the diagnosis of fever from different sources., Fil: Martin-Flores, Manuel. Cornell University. College of Veterinary Medicine. Department of Clinical Sciences; Estados Unidos, Fil: Lorenzutti, Augusto M. Universidad Catolica de Cordoba. Facultad de Ciencias Agropecuarias. Catedra de Farmacologia y Toxicologia; Argentina, Fil: Nugen, Sarah A. Cornell University. College of Veterinary Medicine. Department of Clinical Sciences; Estados Unidos, Fil: Boesch, Jordyn M. Cornell University. College of Veterinary Medicine. Department of Clinical Sciences; Estados Unidos, Fil: Kirch, Pati J. Cornell University. College of Veterinary Medicine. Department of Clinical Sciences; Estados Unidos, Fil: Merry, Hillary L. Cornell University. College of Veterinary Medicine. Department of Clinical Sciences; Estados Unidos, Fil: Campoy, Luis. Cornell University. College of Veterinary Medicine. Department of Clinical Sciences; Estados Unidos

This rapid evidence assessment (REA) was conducted to explore the burden of weight-bearing joint osteoarthritis in the developing countries of Latin America. REA methodology used a standardized search strategy to identify observational studies published from 2010 to 23 April 2020 that reported outcomes pertaining to the epidemiology and humanistic or economic burden of weight-bearing osteoarthritis. Relevant data from each included study were used to populate bespoke data extraction tables and qualitatively analyzed. Thirteen publications were identified that reported on knee and hip osteoarthritis in the Latin American region. Overall prevalence of physician-diagnosed symptomatic knee osteoarthritis in adults ranged from 1.55% in Peru to 7.4% in Ecuador. Total prevalence of grade ≥ 2 radiographic knee osteoarthritis was 22% among those ≥ 39 years of age in Brazil and 25.5% among those ≥ 40 years of age in Mexico. The prevalence of symptomatic/radiographic knee osteoarthritis was 7.1% in people ≥ 18 years of age in Mexico and 17.6% among those ≥ 40 years of age. Prevalence of hip osteoarthritis was similar to or slightly lower than knee osteoarthritis. The limited data available indicates weight-bearing osteoarthritis negatively affects quality of life and that the economic burden may vary between countries with different healthcare systems. The limited evidence found in the published literature suggests the burden of osteoarthritis in Latin America is substantial. Our analysis identified several evidence gaps, particularly for health-related quality of life and socioeconomic outcomes. Further research is of particular importance in areas where government-subsidized healthcare and resources are scarce., Fil: de Andrade, Daniel Ciampi. Hospital das Clínicas; Brasil, Fil: de Andrade, Daniel Ciampi. Aalborg University. Department of Health Science and Technology. Center for Neuroplasticity and Pain; Dinamarca, Fil: de Andrade, Daniel Ciampi. Universidade de São Paulo. Faculdade de Medicina. Pain Center. LIM‑62; Brasil, Fil: Saaibi, Diego. Universidad Autonoma de Bucaramanga; Colombia, Fil: Sarría, Nicolas. Universidad Católica de Córdoba; Argentina, Fil: Sarría, Nicolas. Instituto Oulton; Argentina, Fil: Ruiz, Leslie Cano. Pfizer; Argentina, Fil: Espinosa, Rolando. National Institute of Rehabilitation. Rheumatology Department; México, Fil: Vainstein, Nora. Pfizer; Argentina

Vegetated roofs reduce temperature and heat flow fluctuations on the building's surface mitigating the urban heat island effects and improving other ecosystem services. The objectives of this work were to quantify thermal reduction and to evaluate the performance of vegetated-microcosm treatments during 15 months with different species composition and growth form combinations. Our results showed considerable attenuation of temperature through the whole system of extensive green roofs (EVRs) in both summer and winter periods. The EVRs decreased the outside temperature from 44.6 °C to 34.7 °C. Temperatures for the EVR showed a lower peak-to-valley-gap and better anti-interference performance during the day and along the year. At the same time, thermal insulation provided by soil and vegetation layers resulted in a negative heat flux (−40 W/m2) reducing the incoming heat flux during the day. Almost all treatments showed ≥90% of plant survival and ≥60% of coverage after the experimental period. Microcosm treatments with the highest diversity showed the best performance in both the short and long terms (particularly those with the native Eustachys distichophylla and the exotic Sedum spp.). Consequently, diverse plant arrangements are recommended when designing EVRs in semi-arid climates because they show a better performance in mitigating urban heat island effects by reducing temperature and heat flow fluctuations and also because they provide ecosystem services in urban environments., Fil: Robbiati,F.O. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Diversidad Biológica y Ecología; Argentina, Fil: Cáceres, N. Universidad Católica de Córdoba (UCC)-CONICET. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sánchez Labrador S. J. (IRNASUS). Laboratorio de Recursos Genéticos y Sustentabilidad Bioclimática; Argentina, Fil: Hick, Emmanuel Christian. Universidad Católica de Córdoba (UCC)-CONICET. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sánchez Labrador S. J. (IRNASUS). Laboratorio de Recursos Genéticos y Sustentabilidad Bioclimática; Argentin, Fil: Suárez, Mario Adolfo. Universidad Católica de Córdoba (UCC)-CONICET. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sánchez Labrador S. J. (IRNASUS). Laboratorio de Recursos Genéticos y Sustentabilidad Bioclimática; Argentina, Fil: Soto, S. Instituto de Floricultura (IF)-INTA; Argentina, Fil: Barea, G. Instituto de Ambiente, Hábitat y Energía (INAHE)-CONICET; Argentina, Fil: Matoff, Evangelina. nstituto Nacional de Tecnología Agropecuaria. Agencia de Extensión Rural; Argentina, Fil: Galetto, L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Diversidad Biológica y Ecología; Argentina, Fil: Galetto, L. Universidad Nacional de Córdoba. Instituto Multidisciplinario de Biología Vegetal (IMBIV); Argentina, Fil: Imhof, Lelia. Universidad Católica de Córdoba (UCC)-CONICET. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sánchez Labrador S. J. (IRNASUS). Laboratorio de Recursos Genéticos y Sustentabilidad Bioclimática; Argentina

Sarcoptic mange epidemics can devastate wildlife populations. In 2014, mange was first detected in vicuñas (Vicugna vicugna) and guanacos (Lama guanicoe) in San Guillermo National Park (SGNP), Argentina. This study describes the temporal dynamics of the outbreak, its effects on the park's wild camelid populations between 2017-2019, and investigates the potential source of the epidemic. From May 2017 to June 2018, transect surveys indicated a sharp decrease in the density of living vicuñas and guanacos by 68% and 77%, respectively. By April 2019 no vicuñas or guanacos were recorded on transect surveys, suggesting their near-extinction in the park. Clinical signs consistent with mange (e.g., intense scratching, hyperkeratosis, alopecia) were observed in 24% of living vicuñas (n = 478) and 33% of living guanacos (n = 12) during surveys, as well as in 94% of vicuña carcasses (n = 124) and 85% of guanaco carcasses (n = 20) examined. Sarcoptes scabiei was identified as the causal agent by skin scrapings, and the cutaneous lesions were characterized by histopathology (n = 15). Genetic characterization revealed that mites recovered from seven vicuñas (n = 13) and three guanacos (n = 11) shared the same genotype, which is consistent with a single source and recent origin of the epidemic. Tracing the potential source, we identified a governmental livestock incentive program which introduced llamas (Lama glama) in areas adjacent to SGNP in 2009, some of which had alopecic scaling consistent with sarcoptic mange. Though at the time of our study no llamas with mange were available for confirmatory sampling, we hypothesize that the introduction of mange-infected llamas may have triggered the outbreak in wild camelids. This unprecedented event in SGNP had devastating effects on dominating herbivores with potentially profound cascading effects at the community and ecosystem levels., Fil: del Valle Ferreyra, Hebe. Administración de Parques Nacionales; Argentina, Fil: Rudd, Jaime. University of California. Department of Medicine and Epidemiology; United States, Fil: Foley, Janet. University of California. Department of Medicine and Epidemiology; United States, Fil: Vanstreels, Ralph E.T. University of California. School of Veterinary Medicine. One Health Institute; United States, Fil: Martín, Ana María. Universidad Católica de Córdoba. Departmento de Patología Animal; Argentina, Fil: Donadio, Emiliano. CONICET. Instituto de Investigación en Biodiversidad y Medioambiente (INIBIOMA); Argentina, Fil: Uhart, Marcela M. University of California. School of Veterinary Medicine. One Health Institute; United States

Vegetated roofs (VRs) contribute to the resilience of cities by providing multiple ecosystem functions. A wide range of these benefits depends on the plant layer. Here, we hypothesized that increasing biodiversity attributes (i.e., composition, structural, and functional) in VRs will improve their performance under the climate conditions of semiarid regions. We aimed to (i) characterize functional groups of eight species assessed from key functional traits, (ii) evaluate species performance through survival and coverage, comparing biodiversity attributes from mono to polyculture treatments, (iii) analyze the relationship between performance with biodiversity attributes, and (iv) systematize and rank the treatments using an index to select those with the best performance and to recommend them for VRs in semiarid regions. We expect those treatments with higher biodiversity attributes will show better performances than simpler ones. Functional traits as indicators of ecosystem functions of eight species and four life-forms (succulents: Sedum acre, S. lineare, S. reflexum, creeping herbs: Phyla nodiflora, Glandularia x hybrida, tall forb: Grindelia cabrerae, and grasses: Eustachys distichophylla, and Nassella tenuissima) were evaluated through a trial using 22 microcosms during a 12-month experimental study. A principal component analysis and a cluster analysis were used to detect functional groups according to leaf and plant height traits. We used the Kaplan-Meier analysis to assess species survival among the treatments. Final coverage and growth increment (and their coefficients of variation) were used to construct the performance index. The PCA and CA determined five functional groups: I) succulents; II) creeping herbs; III) N. tenuissima; IV) E. distichophylla, and V) G. cabrerae. Four species showed significantly differences in survival rates among the treatments (p < 0.05), and six treatments were characterized as the best ones: with the highest coverage (>93%) an, Fil: Cáceres, Natalia. Universidad Católica de Córdoba. CONICET. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sánchez Labrador S. J. (IRNASUS). Laboratorio de Recursos Genéticos y Sustentabilidad Bioclimática; Argentina, Fil: Robbiati, Federico O. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales; Argentina, Fil: Hick, Emmanuel C. Universidad Católica de Córdoba. CONICET. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sánchez Labrador S. J. (IRNASUS). Laboratorio de Recursos Genéticos y Sustentabilidad Bioclimática; Argentina, Fil: Suárez, Mario. Universidad Católica de Córdoba. CONICET. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sánchez Labrador S. J. (IRNASUS). Laboratorio de Recursos Genéticos y Sustentabilidad Bioclimática; Argentina, Fil: Matoff, Evangelina. Instituto Nacional de Tecnología Agropecuaria (INTA). Agencia de Extensión Rural Córdoba; Argentina, Fil: Galetto, Leonardo. Universidad Nacional de Córdoba. CONICET. Instituto Multidisciplinario de Biología Vegetal (IMBIV). Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Diversidad Biológica y Ecología; Argentina, Fil: Imhof, Lelia. Universidad Católica de Córdoba. CONICET. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sánchez Labrador S. J. (IRNASUS). Laboratorio de Recursos Genéticos y Sustentabilidad Bioclimática; Argentina

The year 2022 marks the 60th anniversary of the United Nations Declaration of Legal Principles Governing the Activities of States in the Exploration and Use of Outer Space. This could be a good opportunity to reflect upon the challenges that the developments of science and technology have presented to the theological thinking in the last decades. First, I would like to consider the historical context of the UN Declaration, then I will move to our present considering the challenges we face, to conclude with some implications for the theological thinking in a Catholic perspective., Fil: Funes, José Gabriel. Universidad Católica de Córdoba. CONICET; Argentina

Computerized techniques for image analysis are critical for progress in cell biology. The complexity of the data in current methods eliminates the need for manual image analysis and usually requires the application of multiple algorithms sequentially to the images. Our aim was to develop a software for immunohistochemical analysis of brain dopaminergic neurons combining several computational approaches to automatically analyze and quantify their number in the substantia nigra after a neurotoxic injury. For this purpose, we used a Parkinson’s disease animal model to test our application. The dopaminergic neurotoxin, 6-hydroxydopamine, was administered in adult male rats to damage dopaminergic neurons in substantia nigra and to induce hemiparkinsonism. The lesion was corroborated by behavioral evaluation in response to apomorphine and amphetamine. The animals were euthanized and their brains processed for tyrosine hydroxylase immunohistochemistry for dopamine neuron identification. Neurons positive for tyrosine hydroxylase were evaluated in substantia nigra by light microscopy. The images were used to show quantification applicability. To test our software counting accuracy and validity, automatic dopamine neuron number was correlated with the data obtained by three independent observers. Several parameters were used to depict neuronal function in dataset images from control and lesioned brains. In conclusion, we could perform an automated quantification of dopaminergic neurons and corroborate the validity and accuracy of a freely available software., Fil: Bonaccorso Marinelli, María Paula. Universidad de Mendoza. Instituto de Investigaciones Biomédicas (INBIOMED); Argentina, Fil: Bonaccorso Marinelli, María Paula. Universidad Nacional de Cuyo. Instituto de Medicina y Biología Experimental de Cuyo (IMBECU)-CONICET; Argentina, Fil: Bonaccorso Marinelli, María Paula. Universidad de Mendoza. Facultad de Ingeniería. Instituto de Bioingeniería; Argentina, Fil: Baiardi, Gustavo. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina, Fil: Baiardi, Gustavo. Universidad Nacional de Córdoba. Laboratorio de Neurofarmacología, (IIBYT-CONICET); Argentina, Fil: Valdez, Susana Ruth. Universidad Nacional de Cuyo. CONICET. Instituto de Medicina y Biología Experimental de Cuyo (IMBECU). Laboratorio de Reproducción y Lactancia; Argentina, Fil: Valdez, Susana Ruth. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina, Fil: Cabrera, Ricardo Jorge. Universidad de Mendoza. Instituto de Investigaciones Biomédicas (INBIOMED); Argentina, Fil: Cabrera, Ricardo Jorge. Universidad Nacional de Cuyo. Instituto de Medicina y Biología Experimental de Cuyo (IMBECU)-CONICET; Argentina

Metabolic syndrome (MS) is a global health problem. Dietary factors, especially fatty acids, may affect MS pathology. However, the associations between omega-3 polyunsaturated fatty acids (n-3 PUFAs) and MS risk demonstrate inconsistent results. To clarify the relationship between dietary n-3 PUFA and endothelial function on MS, we carried out a systematic review. An electronic literature search based on controlled clinical trials (CCTs) between 2004 and 2020 was conducted. A total of 28 articles were included in the systematic review. Studies were analyzed according intervention type: dietary interventions (12 CCTs), dietary supplementation interventions (9 CCTs) and mixed interventions (7 CCTs). Studies with dietary interventions characterized by n-3 PUFAs increased by food source, such as Mediterranean and Nordic-style diets, reported significant reduction in systolic and diastolic blood pressure, and also in inflammatory endothelial biomarkers. The same effect was also observed in mixed interventions and in CCTs with n-3 PUFAs supple-mentation. Dietary interventions with n-3 PUFAs contributes to improved endothelial and cardiovascular health in SM and associated risk factors., Fil: Bertorello, Natalia Belén. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud. Carrera de Licenciatura en Nutrición; Argentina, Fil: Eynard, Aldo R. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Histología y Embriología. Instituto de Biología Celular; Argentina, Fil: Eynard, Aldo R. Universidad Nacional de Córdoba. CONICET. Instituto de Investigaciones en Ciencias de la Salud (INICSA); Argentina, Fil: Defagó, María Daniela. Universidad Nacional de Córdoba. CONICET. Instituto de Investigaciones en Ciencias de la Salud (INICSA); Argentina, Fil: Defagó, María Daniela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Escuela de Nutrición; Argentina

An ideal protective vaccine against SARS-CoV-2 should not only be effective in preventing disease, but also in preventing virus transmission. It should also be well accepted by the population and have a simple logistic chain. To fulfill these criteria, we developed a thermostable, orally administered vaccine that can induce a robust mucosal neutralizing immune response. We used our platform based on retrovirus-derived enveloped virus-like particles (eVLPs) harnessed with variable surface proteins (VSPs) from the intestinal parasite Giardia lamblia, affording them resistance to degradation and the triggering of robust mucosal cellular and antibody immune responses after oral administration. We made eVLPs expressing various forms of the SARS-CoV-2 Spike protein (S), with or without membrane protein (M) expression. We found that prime-boost administration of VSP-decorated eVLPs expressing a pre-fusion stabilized form of S and M triggers robust mucosal responses against SARS-CoV-2 in mice and hamsters, which translate into complete protection from a viral challenge. Moreover, they dramatically boosted the IgA mucosal response of intramuscularly injected vaccines. We conclude that our thermostable orally administered eVLP vaccine could be a valuable addition to the current arsenal against SARS-CoV-2, in a stand-alone prime-boost vaccination strategy or as a boost for existing vaccines., Fil: Bellier, Bertrand. Sorbonne Université. INSERM. UMRS 959. Immunology-Immunopathology-Immunotherapy; Francia, Fil: Saura, Alicia. Universidad Católica de Córdoba. CONICET. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas (CIDIE); Argentina, Fil: Saura, Alicia. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina, Fil: Luján, Lucas A. Universidad Católica de Córdoba. CONICET. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas (CIDIE); Argentina, Fil: Luján, Lucas A. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina, Fil: Molina, Cecilia R. Universidad Católica de Córdoba. CONICET. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas (CIDIE); Argentina, Fil: Molina, Cecilia R. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina, Fil: Luján, Hugo Daniel. Universidad Católica de Córdoba. CONICET. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas (CIDIE); Argentina, Fil: Luján, Hugo Daniel. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina, Fil: Klatzmann, David. Universidad Católica de Córdoba. CONICET. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas (CIDIE); Argentina, Fil: Klatzmann, David. AP-HP, Hôpital Pitié-Salpêtrière. Clinical Investigation Center for Biotherapies (CIC-BTi) and Immunology-Inflammation-Infectiology and Dermatology Department (3iD); Francia

Experimental laboratory tests were performed using volcanic glasses from Argentina of variable chemical composition and texture, in 1 N KOH, NaOH, Ca(OH)2 and combined NaOH + KOH + Ca(OH)2 solutions, at 40 °C and up to 10 weeks. The initial materials were characterized by petrography, chemical analysis, XRD, FT-IR and DSC-TGA. The reaction progress was evaluated by XRD, and the final products studied by SEM-EDS. The reactivity of the most reactive glass is attributed to a combination of its high porosity/permeability and alteration degree (indirectly assessed by the volatile mass loss up to ~250 °C). The glass silica content and Ca/(Al+Si) ratio could be other factors affecting the glass reactivity; however, more studies are needed to understand the influence of these variables., Fil: Locati, Francisco. CICTERRA (CONICET-UNC); Argentina, Fil: Locati, Francisco. Universidad Católica de Córdoba. Faculty of Engineering; Argentina, Fil: Pérez Marfil, Paula M. Universidad Nacional del Sur. Geology Department - CGAMA (CIC-UNS); Argentina, Fil: Marfil, Silvina A. Universidad Nacional del Sur. Geology Department - CGAMA (CIC-UNS); Argentina, Fil: Lescano, Leticia. Universidad Nacional del Sur. Geology Department - CGAMA (CIC-UNS); Argentina

Hypoxia and hypoxia-reoxygenation are frequently developed through the course of many retinal diseases of different etiologies. Müller glial cells (MGCs), together with microglia and astrocytes, participate firstly in response to the injury and later in the repair of tissue damage. New pharmacological strategies tend to modulate MGCs ability to induce angiogenesis and gliosis in order to accelerate the recovery stage. In this article, we investigated the variation in autophagy flux under hypoxia during 4 h, employing both gas culture chamber (1% O2) and chemical (CoCl2) hypoxia, and also in hypoxia-reoxygenation. Then, we delineated a strategy to induce autophagy with Rapamycin and Resveratrol and analysed the gliotic and pro-angiogenic response of MGCs under hypoxic conditions. Our results showed an increase in LC3B II and p62 protein levels after both hypoxic exposure respect to normoxia. Moreover, 1 h of reoxygenation after gas hypoxia upregulated LC3B II levels respect to hypoxia although a decreased cell survival was observed. Exposure to low oxygen levels increased the protein expression of the glial fibrillary acid protein (GFAP) in MGCs, whereas Vimentin levels remained constant. In our experimental conditions, Rapamycin but not Resveratrol decreased GFAP protein levels in hypoxia. Finally, supernatants of MGCs incubated in hypoxic conditions and in presence of the autophagy inductors inhibited endothelial cells (ECs) tubulogenesis. In agreement with these results, reduced expression of vascular endothelial growth factor (VEGF) mRNA was observed in MGCs with Rapamycin, whereas pigment epithelium-derived factor (PEDF) mRNA levels significantly increased in MGCs incubated with Resveratrol. In conclusion, this research provides evidence about the variation of autophagy flux under hypoxia and hypoxia-reoxygenation as a protective mechanism activated in response to the injury. In addition, beneficial effects were observed with Rapamycin treatment as it decreased, Fil: Subirada, Paula V. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina, Fil: Subirada, Paula V. CONICET. Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI); Argentina, Fil: Joray, Mariana Belén. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina, Fil: Joray, Mariana Belén. CONICET. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sánchez Labrador J. S; Argentina, Fil: Paz, María C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina, Fil: Paz, María C. CONICET. Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI); Argentina, Fil: Barcelona, Pablo F. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina, Fil: Barcelona, Pablo F. CONICET. Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI); Argentina, Fil: Sánchez, María C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina, Fil: Sánchez, María C. CONICET. Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI); Argentina

The human factor is one of the major determinants of animal welfare in zoos. Assessing changes in activity patterns, behavior and space use due to human presence might help understanding visitors’ influence on these animal welfare indicators. In Córdoba (Argentina), we assessed the activity pattern and behavior of Tamandua tetradactyla (lesser anteaters; n = 5) during natural light/dark phases and the animals’ use of space. We analyzed responses of lesser anteaters to humans in days open to the public (Sundays and Tuesdays) and days closed to the public (Mondays), collecting data at 5-minute intervals during 12 days, for each animal. Data were analyzed at two temporal scales: a 24 h period and visiting hours. Multivariate analyses showed no differences in activity pattern, behavior and space use among days, exhibiting a consistent response of each individual over the studied days. Principal Component Analysis showed differences between female and male behaviors. Based on these results, the visitor effect on these lesser anteaters would appear to be neutral, indicating that the presence of visitors is at most, a minor concern in the housing and management of these individuals in Córdoba Zoo., Fil: Chiapero, Florencia. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. CONICET. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina, Fil: Ferrari, Héctor Ricardo. Universidad Nacional de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Bienestar Animal; Argentina, Fil: Prieto, María Valentina. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias. Carrera de Veterinaria; Argentina, Fil: García Capocasa, María Constanza. Jardín Zoológico Córdoba; Argentina, Fil: Busso, Juan Manuel. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. CONICET. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina, Fil: Busso, Juan Manuel. CONICET-Jardín Zoológico Córdoba. Laboratorio de Técnicas No Invasivas; Argentina

This paper addresses the absence of an international diagnostic taxonomy for cognitive disorders in patients with epilepsy. Initiated through the 2020 Memorandum of Understanding between the International League Against Epilepsy and the International Neuropsychological Society, neuropsychological representatives from both organizations met to address the problem and consequences of the absence of an international diagnostic taxonomy for cognitive disorders in epilepsy, overview potential solutions, and propose specific solutions going forward. The group concluded that a classification of cognitive disorders in epilepsy, including an overall taxonomy and associated operational criteria, was clearly lacking and sorely needed. This paper reviews the advantages and shortcomings of four existing cognitive diagnostic approaches, including taxonomies derived from the US National Neuropsychology Network, DSM-V Neurocognitive Disorders, the Mild Cognitive Impairment classification from the aging/preclinical dementia literature, and the Research Domain Criteria Initiative. We propose a framework to develop a consensus-based classification system for cognitive disorders in epilepsy that will be international in scope and be applicable for clinical practice and research globally and introduce the International Classification of Cognitive Disorders in Epilepsy (IC-CODE) project., Fil: Norman, Marc. Department of Psychiatry. University of California; USA., Fil: Wilson, Sarah J. Melbourne School of Psychological Sciences. The University of Melbourne; Australia., Fil: Baxendale, Sallie. Department of Clinical and Experimental Epilepsy. UCL Queen Square Institute of Neurology; UK., Fil: Barr, William. Departments of Neurology and Psychiatry. NYU-Langone Medical Center and NYU Grossman School of Medicine; USA., Fil: Block, Cady. Department of Neurology and Pediatrics. Emory University School of Medicine; USA., Fil: Busch, Robyn M. Epilepsy Center and Department of Neurology. Cleveland Clinic; USA., Fil: Fernández, Albero Luis. Facultad de Filosofía y Humanidades. Universidad Católica de Córdoba; Argentina., Fil: Hessen, Erik. Departments of Psychology and Neurology. University of Oslo and Akershus University Hospital; Norway., Fil: Loring, David W. Department of Neurology and Pediatrics. Emory University School of Medicine; USA., Fil: McDonald, Carrie R. Department of Psychiatry. University of California; USA., Fil: Hermann, Bruce P. Department of Neurology, University of Wisconsin School of Medicine and Public Health; USA.

The acetophenone stereoselective reduction reactions carried out by different chemical or biochemical methodologies reported in the literature were analyzed. This study showed the importance of evaluation in each reaction step, both holistically and quantitatively, even if the amounts used are at the mmol level. It is clear that the use of catalysts does not guarantee that the chemical process is environmentally friendly, as well as that the benefits of bio-driven processes can be diminished due to the complications of product purification. This work shows that the development of tools to determine the sustainability of a process is extremely important., Fil: Bordón, Daniela L. Universidad Nacional De Córdoba. Facultad De Ciencias Exactas Físicas Y Naturales; Argentina, Fil: Decarlini, María F. Universidad Católica De Córdoba. Facultad De Ciencias Químicas; Argentina, Fil: Vázquez, Ana M. Universidad Católica De Córdoba. Facultad De Ciencias Químicas; Argentina, Fil: Demmel, Gabriela I. Universidad Católica De Córdoba. Facultad De Ciencias Químicas; Argentina, Fil: Rossi, Laura I. Universidad Nacional De Córdoba. Facultad De Ciencias Químicas. Departamento De Química Orgánica. SuNaLab; Argentina, Fil: Rossi, Laura I. CONICET-INFIQC; Argentina, Fil: Aimar, Mario L. Universidad Nacional De Córdoba. Facultad De Ciencias Exactas Físicas Y Naturales; Argentina

Sierras de Córdoba (Argentina) is characterized by the occurrence of extreme precipitation events during the austral warm season. Heavy precipitation in the region has a large societal impact, causing flash floods. This motivates the forecast performance evaluation of 24-hour accumulated precipitation and vertical profiles of atmospheric variables from different numerical weather prediction (NWP) models with the final aim of helping water management in the region. The NWP models evaluated include the Global Forecast System (GFS) which parameterizes convection, and convection-permitting simulations of the Weather Research and Forecasting Model (WRF) configured by three institutions: University of Illinois at Urbana-Champaign (UIUC), Colorado State University (CSU) and National Meteorological Service of Argentina (SMN). These models were verified with daily accumulated precipitation data from rain gauges and soundings during the RELAMPAGO-CACTI field campaign. Generally all configurations of the higher-resolution WRFs outperformed the lower-resolution GFS based on multiple metrics. Among the convectionpermitting WRF models, results varied with respect to rainfall threshold and forecast lead time, but the WRFUIUC mostly performed the best. However, elevation dependent biases existed among the models that may impact the use of the data for different applications. There is a dry (moist) bias in lower (upper) pressure levels which is most pronounced in the GFS. For Córdoba an overestimation of the northern flow forecasted by the NWP configurations at lower levels was encountered. These results show the importance of convection-permitting forecasts in this region, which should be complementary to the coarser-resolution global model forecasts to help various users and decision makers., Fil: Casaretto, Gimena. Universidad de Buenos Aires. FCEN. Departamento de Ciencias de la Atmósfera y los Océanos; Argentina, Fil: Casaretto, Gimena. CONICET; Argentina, Fil: Dillon, Maria Eugenia. CONICET; Argentina, Fil: Salio, Paola. Universidad de Buenos Aires. FCEN. Departamento de Ciencias de la Atmósfera y los Océanos; Argentina, Fil: Salio, Paola. Centro de Investigaciones del Mar y la Atmósfera (CIMA/CONICET-UBA); Argentina, Fil: Salio, Paola. Instituto Franco-Argentino para el Estudio del Clima y sus Impactos (UMI IFAECI/CNRS-CONICET-UBA); Argentina, Fil: Skaba García, Yanina. Servicio Meteorológico Nacional; Argentina, Fil: Skaba García, Yanina. CONICET; Argentina, Fil: Skaba García, Yanina. Instituto Franco-Argentino para el Estudio del Clima y sus Impactos (UMI IFAECI/CNRS-CONICET-UBA); Argentina, Fil: Nesbitt, Stephen W. University of Illinois at Urbana-Champaign. Department of Atmospheric Sciences; Estados Unidos, Fil: Schumacher, Russ S. Colorado State University. Department of Atmospheric Science; Estados Unidos, Fil: García, Carlos Marcelo. Instituto de Estudios Avanzados en Ingeniería y Tecnología (IDIT CONICET/UNC); Argentina, Fil: García, Carlos Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina, Fil: Catalini, Carlos. Instituto Nacional del Agua-Subgerencia Centro de la Región Semiárida (INA-CIRSA); Argentina, Fil: Catalini, Carlos. Universidad Católica de Córdoba. Facultad de Ingeniería; Argentina

The planting of native perennial woody species tolerant to variable salt concentrations can facilitate the recovery of degraded dry forests. The objective of this study was to evaluate and compare, under experimentally controlled conditions, the response to saline of young plants from four provenances of Prosopis alba, a mesquite species useful for restoration plans. The seeds of P. alba were from different localities of the Chaco region of Argentina (Santiago del Estero, Chaco, Formosa, and Salta). The plants were evaluated for 45 days under greenhouse-controlled growth conditions in the presence of 0, 100, and 300 mmol·L1 NaCl. We measured variables associated with growth, photosynthesis, and redox state. The imposed salt stress condition did not cause plant death in any provenance. However, salinity produced a strong effect on growth and physiological variables of all provenances. Salta provenance was associated with higher net values of biomass and stem diameter. Chaco registered the greatest relative values of height and stem diameter, indicating a higher salinity tolerance than the other provenances. Chaco also produced more antioxidants to cope with the oxidative stress associated with saline stress. Chaco and Salta provenances may be the most promising for use in restoration plans of dry forests in areas with saline soils in the Chaco region. We emphasize the importance of using different provenances in forest restoration for a more successful system recovery., Fil: Venier, Paula. INTA-CONICET. Unidad de Estudios Agropecuarios; Argentina, Fil: Funes G. CONICET-Universidad Nacional de Córdoba. Instituto Multidisciplinario de Biología Vegetal; Argentina, Fil: Funes G. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina, Fil: Teich I. INTA-CONICET. Unidad de Estudios Agropecuarios; Argentina, Fil: Teich I. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina, Fil: López Lauenstein, Diego A., Fil: Lascano R. INTA-CONICET. Unidad de Estudios Agropecuarios; Argentina, Fil: Lascano R. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina

Approximately 1 billion ha of the global land surface is currently salt-affected, representing about 7% of the earth's land surface. Whereas most of it results from natural geochemical processes, an estimated 30% of irrigated lands globally are salt-affected through secondary human-induced salinization. Application of lower quality, alternative irrigation water is further threatening expansion of the areal extent of soil salinity, in addition to climate change causing increases of salt-water intrusion in coastal areas and increasing crop water requirements. The reduced availability of freshwater resources for irrigation, the continued reduction of the world's cultivated agricultural area by land degradation and urbanization, in conjunction with a growing world population further complicates the problem seeking sustainable solutions. This scoping review prioritizes critical knowledge gaps and makes recommendations for 10 priorities in soil salinity research toward a sustainable and productive agricultural system for a food-secure future world. We also include basin-specific case studies that illustrate progress of the world's major irrigated areas in addressing impacts of soil salinization. By identifying research priorities, we seek to accelerate enhanced research funding to bring new knowledge and innovative solutions toward mitigation of soil salinity impacts. We further want to inspire the science community to develop new directions in salinity research., Fil: Hopmans, Jan W. University of California. Department of Land, Air and Water Resources; Estados Unidos, Fil: Qureshi A.S. International Center for Biosaline Agriculture (ICBA). Irrigation and Water Management; Emiratos Árabes Unidos, Fil: Kisekka I. University of California. Department of Land, Air and Water Resources; Estados Unidos, Fil: Munns R. CSIRO Agriculture and Food; Australia, Fil: Munns R. University of Western Australia. School of Molecular Sciences. ARC Centre of Excellence in Plant Energy Biology; Australia, Fil: Grattan S.R. University of California. Department of Land, Air and Water Resources; Estados Unidos, Fil: Rengasamy P. University of Adelaide. School of Agriculture, Food and Wine; Australia, Fil: Ben-Gal A. Agricultural Research Organization. Soil, Water and Environmental Sciences; Israel, Fil: Assouline S. Agricultural Research Organization. Department of Environmental Physics and Irrigation; Israel, Fil: Javaux M. Université catholique de Louvain. Earth and Life Institute; Bélgica, Fil: Minhas P.S. ICAR Central Soil Salinity Research Institute; India, Fil: Raats P.A.C. Wageningen University and Research Center (WUR); Países Bajos, Fil: Skaggs T.H. United States Salinity Laboratory. USDA Agricultural Research Service; Estados Unidos, Fil: Wang G. China Agricultural University. Department of Soil and Water Sciences; China, Fil: De Jong van Lier Q. University of São Paulo. CENA; Brasil, Fil: Jiao H. China Agricultural University. Department of Soil and Water Sciences; China, Fil: Lavado R.S. Universidad de Buenos Aires and INBA—CONICET/UBA; Argentina, Fil: Lazarovitch N. Ben-Gurion University of the Negev. The Jacob Blaustein Institutes for Desert Research. French Associates Institute for Agriculture and Biotechnology of Dryland; Israel, Fil: Li B. China Agricultural University. Department of Soil and Water Sciences; China, Fil: Taleisnik E. Universidad Católica de Córdoba. CONICET, IFRGV-CIAP INTA and Facultad de Ciencias Agropecuarias; Argentina

This work presents a novel methodology for measuring gamma radiation doses, based on an OBIST (Oscillation-Based Built In Self-Testing) scheme. The studied circuit has a configuration of a Colpitts oscillator designed with three nMOS transistors. The gamma radiation incidence on the transistors produces a shift in the threshold voltage, which changes the oscillation frequency and makes it possible to measure the value of the radiation dose., Fil: Castagnola, Juan L. Universidad Católica de Córdoba. Facultad de Ingeniería; Argentina, Fil: Petrashin, Pablo A. Universidad Católica de Córdoba. Facultad de Ingeniería; Argentina, Fil: Laprovitta, Agustin M. Universidad Católica de Córdoba. Facultad de Ingeniería; Argentina, Fil: Lancioni, Walter J. Universidad Católica de Córdoba. Facultad de Ingeniería; Argentina

El Parkinson es una enfermedad neurodegenerativa crónica y progresiva, que se manifiesta con la aparición de signos y síntomas motores como temblores y rigidez. Mostraremos la eficacia de levodopa y rasagilina utilizados para la enfermedad del Párkinson basándonos en una revisión bibliográfica. La eficacia para el tratamiento de la EP documenta ser muy buena tanto en rasagilina como en levodopa. No hay evidencia suficiente para determinar que el sexo sea una variable que afecte la eficacia tanto de levodopa (Ldopa) como de rasagilina., Fil: Alegría Cáceres, Tomás. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina., Fil: Gaida, Catalina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina., Fil: Saavedra, María Guadalupe. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.

Actualmente, el planeta está atravesando una situación preocupante con respecto a la contaminación ambiental que conlleva al deterioro progresivo de la capa de ozono, provocando un aumento en la incidencia de la radiación solar sobre la piel humana. Esto incrementa la probabilidad de padecer alteraciones en la piel por lo que es necesario tomar medidas de protección como el uso de fotoprotectores que formen una pantalla e impidan el paso de los rayos solares en la piel. Las formulaciones de fotoprotectores desarrolladas contienen compuestos orgánicos que actúan como filtros químicos que absorben las radiaciones, estos podrían ser nocivos para la piel provocando reacciones alérgicas, irritación u otras alteraciones y según investigaciones realizadas recientemente, también podrían desarrollar efectos carcinogénicos. A causa de la preocupación por la potencial toxicidad sobre la piel que presentan estas partículas a base de metales surge la investigación de principios activos de origen natural que puedan reemplazar los filtros conocidos y así formular productos menos nocivos para la piel. Además, debido a la actual revolución digital se observaron daños en la piel provocados por la luz azul la cual es parte del espectro de radiación visible, por lo que la investigación de principios activos naturales se realizó con el objetivo de no solo cubrir el espectro UV si no también la luz azul. Para la presente investigación se realizó una revisión bibliográfica en distintas plataformas y se llevó a cabo la recopilación de datos obtenida a través de encuestas, sobre la concientización de las personas con respecto al uso de los fotoprotectores y del conocimiento de la luz azul., Fil: Cardonatto, Luisina Magalí. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina., Fil: Ravasi, Lara. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina., Fil: Sucaria, Romina Paola. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina.

Este trabajo analiza la huella de carbono y la huella energética del etanol anhidro de maíz producido en una destilería de pequeña escala (minidest) de un productor indicado como representativo por parte de la Cámara de Industrializadores de Granos y Productores de Biocombustibles en Origen (CIGBO), con sede en Córdoba, Argentina. La huella de carbono representa la totalidad de gases de efecto invernadero emitidos por un producto, mientras que la huella energética comprende el total de energía consumida en la producción de un bien. El establecimiento evaluado está ubicado en Buena Esperanza, San Luis, produce su propio maíz para la obtención del etanol, y aprovecha los subproductos (burlanda y vinaza) para la producción de carne bovina en un feedlot contiguo. En este modelo se aprovecha el estiércol recuperado del feedlot que junto con silo de maíz de producción propia son destinados a un biodigestor que genera energía eléctrica y calor, lo que permite abastecer las necesidades de la minidest y vender energía eléctrica a la red. A su vez el digestato, un subproducto del biodigestor, se usa como reemplazo del fertilizante a campo. La unidad funcional es 1 MegaJoule (MJ) de etanol, y el alcance abarca desde la cuna hasta la puerta de la destilería, en la campaña 2018/2019. Se analizaron diferentes métodos de asignación y se destaca la asignación por contenido energético. Los resultados indican una huella de carbono de 19,9 g CO2 equivalente/MJ y un balance energético de 0,23 MJ de energía invertida por MJ de etanol producido. La huella de carbono significa una reducción del 76% con respecto al combustible fósil de referencia de la Directiva 2018/2001 de la Unión Europea (European Union, 2018). Se detectaron hotspots ambientales en la producción primaria y en destilería, y se realizaron análisis de sensibilidad., Fil: Bongiovanni, Rodolfo Gustavo. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina, Fil: Tuninetti, L. Instituto Nacional de Tecnología Industrial (INTI); Argentina

La farmacia comprende el conocimiento integral de los medicamentos, productos cosméticos, higiénicos, germicidas, productos médicos y ortopédicos. Incluye el diseño molecular de los principios farmacológicamente activos, la elaboración, conservación, control de calidad, distribución y todo lo relacionado con el paciente desde la dispensación del fármaco hasta el seguimiento fármaco-terapéutico. Conocé cómo es estudiarla en la Católica., Fil: Universidad Católica de Córdoba, Argentina., Fil: Universidad Católica de Córdoba, Argentina.

Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; Argentina, Fil: Vidales, Silvia Noemí. Universidad Católica de Córdoba. Facultad de Educación; Argentina

El programa está destinado a la formación de personas que realicen actividades por la cual estén o pudieran estar en contacto con alimentos, en establecimientos donde se elaboren, fraccionen, almacenen, transporten, comercialicen y/o enajenen alimentos, o sus materias primas, con la finalidad de acreditar conocimientos y competencias de la manipulación segura de alimentos frente a las autoridades sanitarias correspondientes que emiten el Carnet de Manipulador de Alimentos., Fil: Universidad Católica de Córdoba, Argentina., Fil: Universidad Católica de Córdoba, Argentina.

Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; Argentina, Fil: Bovo, Marcos hernán. Universidad Católica de Córdoba. Facultad de Educación; Argentina, Fil: Bono, Laura Cecilia. Universidad Católica de Córdoba. Facultad de Educación; Argentina