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The Covid-19 pandemic has forced Ukraine, like other countries, to move to distance education. The study aims to analyze the distance learning experience of Ukrainian philology students, to find out the pros and cons of distance education, those things that motivate students, and the challenges they face while studying online. The survey consisted of a questionnaire and embraced 105 respondents. The survey goal was to collect data "that would allow concluding about the effectiveness of distance education for" Ukrainian philology students at the National University of Life and Environmental Sciences of Ukraine, "particularly for the study of foreign languages." The significant results of the survey include: obtaining reliable data on the effectiveness of distance learning of Ukrainian philology students through their feedback in questionnaires, online testing, a variety of writing assignments, and assessment in the online classroom, finding out the most effective distance learning tools, the main features of teacher -- students interactions in a distance-learning environment. The research proves that Ukrainian philology students overall positively evaluate their distance learning experience. It does not negatively impact students' foreign language learning motivation. Despite a positive attitude to distance learning, Ukrainian philology students face particular challenges connected with access to devices, lack of information and communications technology skills, Internet connection, and lack of communication with their peers. The finding reveals, whatever are the benefits of distance education, it cannot entirely replace face-to-face learning.

The present work is devoted to the in silico study of 2-(3-R-1H-1,2,4-triazol-5-yl)anilines as potential inhibitors of EGFR (epidermal growth factor receptor) and RET (rearranged during transfection)-, which play a significant role in regulating the physiological cycle of non-small cell lung cancer. The well-known docking software AutoDock Vina was used for the study. The seven studied compounds and two standard drugs (vandetanib and gefitinib) were docked to the crystal structures of EGFR and RET proteins. It was found that among the newly investigated substances, 2-(3-(indolyl-2)-1H-1,2,4-triazol-5-yl)aniline (a5) has the highest affinity towards EGFR and RET with the binding energy of --9.7 and --8.7 kcal/mol, respectively. Visualization of the molecular docking results of this compound using the Discovery Studio software showed that it is characterized by similar to standard ligands location in the active sites of the enzymes, stable hydrogen bonds and π-stacking interactions, which are provided by the presence of indole and aniline fragments in the molecule. Thus, we have identified a new effective ligand that can be used as a "base" molecule for further fragment-oriented design using molecular hybridization methodology (fragment fusion, coupling or extension methods) or structural modification by introducing "pharmacophore" groups into the molecule. Summarizing the above screening results, we can say that 2-(3-R-1H-1,2,4-triazol-5- yl)anilines require further careful consideration as effective tyrosine kinase inhibitors for the search for promising anticancer agents for the treatment of non-small cell lung cancer. [ABSTRACT FROM AUTHOR]

The Covid-19 pandemic has forced Ukraine, like other countries, to move to distance education. The study aims to analyze the distance learning experience of Ukrainian philology students, to find out the pros and cons of distance education, those things that motivate students, and the challenges they face while studying online. The survey consisted of a questionnaire and embraced 105 respondents. The survey goal was to collect data that would allow concluding about the effectiveness of distance education for Ukrainian philology students at the National University of Life and Environmental Sciences of Ukraine, particularly for the study of foreign languages. The significant results of the survey include: obtaining reliable data on the effectiveness of distance learning of Ukrainian philology students through their feedback in questionnaires, online testing, a variety of writing assignments, and assessment in the online classroom, finding out the most effective distance learning tools, the main features of teacher -- students interactions in a distance-learning environment. The research proves that Ukrainian philology students overall positively evaluate their distance learning experience. It does not negatively impact students' foreign language learning motivation. Despite a positive attitude to distance learning, Ukrainian philology students face particular challenges connected with access to devices, lack of information and communications technology skills, Internet connection, and lack of communication with their peers. The finding reveals, whatever are the benefits of distance education, it cannot entirely replace face-to-face learning. [ABSTRACT FROM AUTHOR]

The structures of the REP-1 in complex with monoprenylated and C terminally truncated Rab7:GDP are reported. Further, the structures of apo-Rab7 in the GDP- and GppNHp bound states that provide detailed information on the nature of nucleotide-dependent interaction of RabGTPases with REP proteins is presented.

Cytochrome P450 enzymes participate in several biological functions and act as catalysts for an extended range of reactions. The present study describes the formation of organic and gaseous ligand binding and electron relocation in bacterial and fungal P450s.