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33 results on '"Pyle‐Eilola, Amy L."'

5. Beyond the bias! Sex distribution in paediatric growth hormone deficiency reexamined.

Author

Henry, Rohan K., Mamilly, Leena, Chaudhari, Monika, Klamer, Brett G., Nikahd, Melica, and Pyle‐Eilola, Amy L.

Subjects
PITUITARY dwarfism, SEX distribution, HORMONE deficiencies, SHORT stature, PITUITARY gland, PITUITARY hormones
Abstract

Objectives: Various biases pertaining to stature account for a male sex predominance in growth hormone deficiency (GHD) cases diagnosed by endocrinology clinics. This manuscript will assess the sex distribution when biases are minimised. Methods: Retrospective chart review was conducted on patients diagnosed with GHD between 3 and 16 years of age. The sex distribution of cases was ascertained according to: (1) peak GH (pGH) by groups; based on growth hormone provocative testing, (2) pituitary gland imaging results, and (3) isolated GHD (IGHD) versus multiple pituitary hormone deficiencies (MPHD). The relative frequency of each sex was compared according to these subgroups with significance evaluated at α =.05 level. Results: Of the 5880 clinic referrals for short stature, there were 3709 boys (63%) and 2171 girls (37%). Of these, 20% of boys (n = 745) and 15.3% of girls (n = 332) underwent provocative testing for GHD. Of those tested, 39.2% of boys (n = 292) and 32.2% of girls (n = 107) were diagnosed with GHD, all p <.001. There was a male predominance in GHD cases based on pGH or GHD severity. Though not significant, girls were more likely than boys to have MPHD (p =.056), even across pGH groups (p =.06). Both boys and girls had a similar distribution of imaging abnormalities. Conclusion: Stratifying by sex, we found similar percentages of pituitary imaging abnormalities (including tumours) and the number of pituitary hormone deficiencies in boys and girls as the cause of GHD. For these classifications, we did not find the historically reported male sex predominance. [ABSTRACT FROM AUTHOR]

Published
2024
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6. List of contributors

Author

Adeli, Khosrow, primary, Alter, David N., additional, Babady, Esther, additional, Bachmann, Lorin M., additional, Bai, Shi, additional, Block, Darci R., additional, Campbell, Sean, additional, Chambliss, Allison B., additional, Chan, Daniel W., additional, Chin, Alex C., additional, Christenson, Robert H., additional, Clarke, William, additional, Colby, Jennifer M., additional, Connelly, Margery A., additional, Cotten, Steven W., additional, Dahlin, Jayme L., additional, Deharvengt, Sophie J., additional, Delvin, Edgard, additional, Dickerson, Jane, additional, Donato, Leslie J., additional, D’Orazio, Paul, additional, Dufour, D. Robert, additional, Duh, Show-Hong, additional, Eckel, Ashley, additional, Fan, Shu-Ling, additional, Frank, Elizabeth L., additional, Franke, Deanna D.H., additional, Genzen, Jonathan R., additional, Greene, Dina N., additional, Hage, David S., additional, Harris, Neil S., additional, Henderson, Matthew P.A., additional, Higgins, Victoria, additional, Holmes, Daniel T., additional, Inker, Lesley A., additional, Jackson, Brian R., additional, Jannetto, Paul J., additional, Jung, Hou-Sung, additional, Kahn, Stephen E., additional, Kavsak, Peter A., additional, Korpi-Steiner, Nichole, additional, Langman, Loralie J., additional, Leung, Stanley T., additional, Levy, Emile, additional, Liesman, Rachael, additional, Lin, David C., additional, Lockwood, Christina M., additional, Marzinke, Mark A., additional, Master, Stephen R., additional, McCudden, Christopher R., additional, McMillin, Gwendolyn A., additional, Meeusen, Jeffrey W., additional, Melanson, Stacy E.F., additional, Merrill, Anna E., additional, Miller, W. Greg, additional, Nerenz, Robert D., additional, Nichols, James H., additional, Nieuwesteeg, Michelle, additional, Park, Jason Y., additional, Parnás, M. Laura, additional, Patel, Khushbu, additional, Pelletier, J. Peter R., additional, Pence, Morgan A., additional, Petersen, Lauren M., additional, Petrides, Athena K., additional, Pyle-Eilola, Amy L., additional, Rai, Alex J., additional, Shajani-Yi, Zahra, additional, Sokoll, Lori J., additional, Straseski, Joely A., additional, Thomas, Stefani N., additional, Thoren, Katie L., additional, Toffaletti, John, additional, Truscott, Steven M., additional, Tsongalis, Gregory J., additional, Ware, Alisha D., additional, Wiencek, Joesph R., additional, Willrich, Maria Alice V., additional, Winter, William E., additional, Woodworth, Alison, additional, and Wu, Alan H.B., additional

Published
2020
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9. List of contributors

Author

Abdullah, Amid, primary, Alfaro, Maria P., additional, Altomare, Chris, additional, Baskin, Leland, additional, Bazydlo, Lindsay A.L., additional, Boyd, Jessica M., additional, Broussard, Larry A., additional, Chávez, Violeta, additional, Chin, Alex, additional, Costantino, Anthony G., additional, Dasgupta, Amitava, additional, Datta, Pradip, additional, DeSimone, Robert A., additional, Garg, Uttam, additional, Harris, Neil S., additional, Hayden, Joshua, additional, Hsiao, Susan J., additional, Jacobsen, Laura M., additional, Johnson-Davis, Kamisha L., additional, Kazmierczak, Steven C., additional, Lyon, Elaine, additional, McMillin, Gwendolyn A., additional, Naugler, Christopher, additional, Nedelcu, Elena G., additional, Nguyen, Andy, additional, Peck Palmer, Octavia M., additional, Pyle-Eilola, Amy L., additional, Sadrzadeh, S.M. Hossein, additional, Sepulveda, Jorge L., additional, Shy, Brian Rudolph, additional, Stella, Aaron, additional, Tanhehco, Yvette C., additional, Tholpady, Ashok, additional, Trambas, Christina, additional, Vlad, George, additional, Wahed, Amer, additional, Winter, William E., additional, and Woodworth, Alison, additional

Published
2019
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10. Reply

Author

Thomas, Stefani N., primary, Stieglitz, Heather M., additional, Hackenmueller, Sarah, additional, Suh-Lailam, Brenda, additional, and Pyle-Eilola, Amy L., additional

Published
2023
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14. Current State of Pediatric Reference Intervals and the Importance of Correctly Describing the Biochemistry of Child Development

Author

Lyle, Alicia N., primary, Pokuah, Fidelia, additional, Dietzen, Dennis J., additional, Wong, Edward C. C., additional, Pyle-Eilola, Amy L., additional, Fuqua, John S., additional, Woodworth, Alison, additional, Jones, Patricia M., additional, Akinbami, Lara J., additional, Garibaldi, Luigi R., additional, and Vesper, Hubert W., additional

Published
2022
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29. Is This Drug Screen Really Negative? Special Investigation of Drug Screening in Pediatrics.

Author

Pyle-Eilola, Amy L., Thornton, David J., Hays, Hannah L., and Casavant, Marcel J.

Subjects
DRUG use testing, HEROIN, OPIOIDS, URINALYSIS, DRUGS of abuse
Abstract

The article describes the case of a three-month-old male with a negative qualitative opioid result on a urine drug screen using routine cutoff but a positive confirmation for heroin. Topics discussed include how the urine drug screen was performed, potential of illicit drug exposure for serious ramifications, and the need to report drug screen results below the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) cutoffs for medical cases, especially in pediatrics.

Published
2017
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