1. La procalcitonine : un marqueur utile pour l’enfant présentant une infection urinaire
- Author
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Alain Gervaix and Sandrine Leroy
- Subjects
medicine.medical_specialty ,Adolescent ,Bacterial Infections/blood/complications/diagnosis ,Urinary system ,Urinary Tract Infections/blood/diagnosis/microbiology ,urologic and male genital diseases ,Sensitivity and Specificity ,Severity of Illness Index ,Gastroenterology ,Procalcitonin ,Cystography ,Predictive Value of Tests ,Internal medicine ,Severity of illness ,medicine ,Humans ,Biological Markers/blood ,Child ,DMSA scan ,ddc:618 ,Evidence-Based Medicine ,medicine.diagnostic_test ,Protein Precursors/blood ,Vesico-Ureteral Reflux/blood/diagnosis/microbiology ,business.industry ,Pyelonephritis/blood/diagnosis/microbiology ,Gold standard ,Reflux ,Calcitonin/blood ,female genital diseases and pregnancy complications ,Predictive value of tests ,Pediatrics, Perinatology and Child Health ,business - Abstract
Urinary tract infections (UTIs) are one of the most common sources of bacterial infections among young febrile children. Accurate diagnosis of acute pyelonephritis (APN) and vesico-ureteral reflux (VUR) are important because of their association with renal scarring, sometimes leading to long-term complications. However, the gold standard examinations are either a DMSA scan for APN and scarring, or cystography for VUR, but both present limitations (feasibility, pain, cost, etc.). Procalcitonin, a reliable marker of bacterial infections, was demonstrated to be a good predictor of renal parenchymal involvement in the acute phase and in late renal scars, as well as of high-grade VUR. These findings need further broad validations and impact studies before being implemented into daily practice. However, procalcitonin may play a role in the complex and still debated picture of which examination should be performed after UTI in children.
- Published
- 2013
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