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1. Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.

Author

Moayyeri, Alireza, Hsu, Yi-Hsiang, Karasik, David, Estrada, Karol, Xiao, Su-Mei, Nielson, Carrie, Srikanth, Priya, Giroux, Sylvie, Wilson, Scott G, Zheng, Hou-Feng, Smith, Albert V, Pye, Stephen R, Leo, Paul J, Teumer, Alexander, Hwang, Joo-Yeon, Ohlsson, Claes, McGuigan, Fiona, Minster, Ryan L, Hayward, Caroline, Olmos, José M, Lyytikäinen, Leo-Pekka, Lewis, Joshua R, Swart, Karin MA, Masi, Laura, Oldmeadow, Chris, Holliday, Elizabeth G, Cheng, Sulin, van Schoor, Natasja M, Harvey, Nicholas C, Kruk, Marcin, del Greco M, Fabiola, Igl, Wilmar, Trummer, Olivia, Grigoriou, Efi, Luben, Robert, Liu, Ching-Ti, Zhou, Yanhua, Oei, Ling, Medina-Gomez, Carolina, Zmuda, Joseph, Tranah, Greg, Brown, Suzanne J, Williams, Frances M, Soranzo, Nicole, Jakobsdottir, Johanna, Siggeirsdottir, Kristin, Holliday, Kate L, Hannemann, Anke, Go, Min Jin, Garcia, Melissa, Polasek, Ozren, Laaksonen, Marika, Zhu, Kun, Enneman, Anke W, McEvoy, Mark, Peel, Roseanne, Sham, Pak Chung, Jaworski, Maciej, Johansson, Åsa, Hicks, Andrew A, Pludowski, Pawel, Scott, Rodney, Dhonukshe-Rutten, Rosalie AM, van der Velde, Nathalie, Kähönen, Mika, Viikari, Jorma S, Sievänen, Harri, Raitakari, Olli T, González-Macías, Jesús, Hernández, Jose L, Mellström, Dan, Ljunggren, Osten, Cho, Yoon Shin, Völker, Uwe, Nauck, Matthias, Homuth, Georg, Völzke, Henry, Haring, Robin, Brown, Matthew A, McCloskey, Eugene, Nicholson, Geoffrey C, Eastell, Richard, Eisman, John A, Jones, Graeme, Reid, Ian R, Dennison, Elaine M, Wark, John, Boonen, Steven, Vanderschueren, Dirk, Wu, Frederick CW, Aspelund, Thor, Richards, J Brent, Bauer, Doug, Hofman, Albert, Khaw, Kay-Tee, Dedoussis, George, Obermayer-Pietsch, Barbara, Gyllensten, Ulf, Pramstaller, Peter P, and Lorenc, Roman S

Subjects
Calcaneus, Humans, Osteoporosis, Genetic Predisposition to Disease, Ultrasonography, Cohort Studies, Bone Density, Polymorphism, Single Nucleotide, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Fractures, Bone, Genome-Wide Association Study, Young Adult, Human Genome, Genetics, Aging, 2.1 Biological and endogenous factors, Aetiology, Musculoskeletal, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 × 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 × 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 × 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology.

Published
2014

2. Genetic determinants of serum testosterone concentrations in men.

Author

Ohlsson, Claes, Wallaschofski, Henri, Lunetta, Kathryn L, Stolk, Lisette, Perry, John RB, Koster, Annemarie, Petersen, Ann-Kristin, Eriksson, Joel, Lehtimäki, Terho, Huhtaniemi, Ilpo T, Hammond, Geoffrey L, Maggio, Marcello, Coviello, Andrea D, EMAS Study Group, Ferrucci, Luigi, Heier, Margit, Hofman, Albert, Holliday, Kate L, Jansson, John-Olov, Kähönen, Mika, Karasik, David, Karlsson, Magnus K, Kiel, Douglas P, Liu, Yongmei, Ljunggren, Osten, Lorentzon, Mattias, Lyytikäinen, Leo-Pekka, Meitinger, Thomas, Mellström, Dan, Melzer, David, Miljkovic, Iva, Nauck, Matthias, Nilsson, Maria, Penninx, Brenda, Pye, Stephen R, Vasan, Ramachandran S, Reincke, Martin, Rivadeneira, Fernando, Tajar, Abdelouahid, Teumer, Alexander, Uitterlinden, André G, Ulloor, Jagadish, Viikari, Jorma, Völker, Uwe, Völzke, Henry, Wichmann, H Erich, Wu, Tsung-Sheng, Zhuang, Wei Vivian, Ziv, Elad, Wu, Frederick CW, Raitakari, Olli, Eriksson, Anna, Bidlingmaier, Martin, Harris, Tamara B, Murray, Anna, de Jong, Frank H, Murabito, Joanne M, Bhasin, Shalender, Vandenput, Liesbeth, and Haring, Robin

Subjects
EMAS Study Group, Chromosomes, Human, X, Humans, Testosterone, Sex Hormone-Binding Globulin, Nuclear Proteins, Body Mass Index, Polymorphism, Single Nucleotide, Alleles, Adult, Aged, 80 and over, Middle Aged, Male, Genome-Wide Association Study, Aged, and over, Chromosomes, Human, X, Polymorphism, Single Nucleotide, Genetics, Developmental Biology
Abstract

Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as

Published
2011

3. Elevated luteinizing hormone despite normal testosterone levels in older men—natural history, risk factors and clinical features

Author

Eendebak, Robert J. A. H., Ahern, Tomas, Swiecicka, Agnieszka, Pye, Stephen R., OʼNeill, Terence W., Bartfai, Gyorgy, Casanueva, Felipe F., Maggi, Mario, Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Słowikowska‐Hilczer, Jolanta, Lean, Michael E. J., Punab, Margus, Pendleton, Neil, Keevil, Brian G., Vanderschueren, Dirk, Rutter, Martin K., Tampubolon, Gindo, Goodacre, Royston, Huhtaniemi, Ilpo T., and Wu, Frederick C. W.

Published
2018
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4. Chronic widespread pain is associated with worsening frailty in European men

Author

Wade, Katie Fredrika, Lee, David M., McBeth, John, Ravindrarajah, Rathi, Gielen, Evelien, Pye, Stephen R., Vanderschueren, Dirk, Pendleton, Neil, Finn, Joseph D., Bartfai, György, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Punab, Margus, Wu, Frederick C. W., and OʼNeill, Terence W.

Published
2016
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5. Low heel ultrasound parameters predict mortality in men: results from the European Male Ageing Study (EMAS)

Author

Pye, Stephen R., Vanderschueren, Dirk, Boonen, Steven, Gielen, Evelien, Adams, Judith E., Ward, Kate A., Lee, David M., Bartfai, György, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E., Pendleton, Neil, Punab, Margus, Wu, Frederick C., and OʼNeill, Terence W.

Published
2015
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6. Associations Between Sex Steroids and the Development of Metabolic Syndrome: A Longitudinal Study in European Men

Author

Antonio, Leen, Wu, Frederick C. W., OʼNeill, Terence W., Pye, Stephen R., Carter, Emma L., Finn, Joseph D., Rutter, Martin K., Laurent, Michaël R., Huhtaniemi, Ilpo T., Han, Thang S., Lean, Michael E. J., Keevil, Brian G., Pendleton, Neil, Rastrelli, Giulia, Forti, Gianni, Bartfai, Gyorgy, Casanueva, Felipe F., Kula, Krzysztof, Punab, Margus, Giwercman, Aleksander, Claessens, Frank, Decallonne, Brigitte, and Vanderschueren, Dirk

Published
2015

7. Influence of Polymorphisms in the RANKL/RANK/OPG Signaling Pathway on Volumetric Bone Mineral Density and Bone Geometry at the Forearm in Men

Author

Roshandel, Delnaz, Holliday, Kate L., Pye, Stephen R., Ward, Kate A., Boonen, Steven, Vanderschueren, Dirk, Borghs, Herman, Huhtaniemi, Ilpo T., Adams, Judith E., Bartfai, Gyorgy, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Lean, Michael E., Pendleton, Neil, Punab, Margus, Silman, Alan J., Wu, Frederick C., Thomson, Wendy, O’Neill, Terence W., and The EMAS Study Group

Published
2011
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8. Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on Bone Health: Results from the European Male Ageing Study

Author

Pye, Stephen R., Almusalam, Bader, Boonen, Steven, Vanderschueren, Dirk, Borghs, Herman, Gielen, Evelien, Adams, Judith E., Ward, Kate A., Bartfai, Gyorgy, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Labrie, Fernand, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Silman, Alan J., Wu, Frederick C. W., O’Neill, Terence W., and The EMAS Study Group

Published
2011
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9. Influence of Lifestyle Factors on Quantitative Heel Ultrasound Measurements in Middle-Aged and Elderly Men

Author

Pye, Stephen R., Devakumar, Vinodh, Boonen, Steven, Borghs, Herman, Vanderschueren, Dirk, Adams, Judith E., Ward, Kate A., Bartfai, Gyorgy, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Silman, Alan J., Wu, Frederick C. W., O’Neill, Terence W., and EMAS Study Group

Published
2010
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10. Identification of late-onset hypogonadism in middle-aged and elderly men

Author

Wu, Frederick C.W., Tajar, Abdelouahid, Beynon, Jennifer M., Pye, Stephen R., Silman, Alan J., O'Neill, Terence W., Bartfai, Gyorgy, Finn, Joseph D., Casanueva, Felipe F., Giwercman, Aleksander, Forti, Gianni, Han, Thang S., Kula, Krzysztof, Lean, Michael E.J., Pendleton, Neil, Punab, Margus, Boonen, Steven, Vanderschueren, Dirk, Labrie, Fernand, and Huhtaniemi, Ilpo T.

Subjects
Hypogonadism -- Diagnosis, Hypogonadism -- Surveys, Middle aged men -- Health aspects, Middle aged men -- Surveys, Aged men -- Health aspects, Aged men -- Surveys
Abstract

A questionnaires base survey was conducted among a random population sample of 3369 men between the ages of 40 and 79 years at Eight European centers to determine the link between aging-related testosterone deficiency and late-onset hypogonadism in the general population. The data for the general population indicated that the presence of three sexual symptoms combined with a total testosterone level of less than 11 nmol per liter and a free testosterone level of less than 220 pmol per liter could be considered the minimum criteria for the diagnosis of late-onset hypogonadism in aging men.

Published
2010

11. Association of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone with mortality among middle-aged and older European men

Author

Lee, David M., Vanderschueren, Dirk, Boonen, Steven, OʼNeill, Terence W., Pendleton, Neil, Pye, Stephen R., Ravindrarajah, Rathi, Gielen, Evelien, Claessens, Frank, Bartfai, György, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Punab, Margus, and Wu, Frederick C. W.

Published
2014
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16. Frailty and Sexual Health in Older European Men

Author

Lee, David M., Tajar, Abdelouahid, Ravindrarajah, Rathi, Pye, Stephen R., O’Connor, Daryl B., Corona, Giovanni, O’Connell, Matthew, Gielen, Evelien, Boonen, Steven, Vanderschueren, Dirk, Pendleton, Neil, Finn, Joseph D., Bartfai, György, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Punab, Margus, Wu, Frederick C. W., and O’Neill, Terence W.

Published
2013
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17. Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men

Author

Ohlsson, Claes, Nilsson, Maria E., Tivesten, Åsa, Ryberg, Henrik, Mellström, Dan, Karlsson, Magnus K., Ljunggren, Östen, Labrie, Fernand, Orwoll, Eric S., Lee, David M., Pye, Stephen R., OʼNeill, Terence W., Finn, Joseph D., Adams, Judith E., Ward, Kate A., Boonen, Steven, Bartfai, Gyorgy, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C. W., and Vandenput, Liesbeth

Published
2013

18. The association of frailty with serum 25-hydroxyvitamin D and parathyroid hormone levels in older European men

Author

Tajar, Abdelouahid, Lee, David M., Pye, Stephen R., OʼConnell, Matthew D. L., Ravindrarajah, Rathi, Gielen, Evelien, Boonen, Steven, Vanderschueren, Dirk, Pendleton, Neil, Finn, Joseph D., Bartfai, György, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Punab, Margus, Wu, Frederick C. W., and OʼNeill, Terence W.

Published
2013
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19. Cohort Profile: The European Male Ageing Study

Author

Lee, David M, Pye, Stephen R, Tajar, Abdelouahid, OʼNeill, Terence W, Finn, Joseph D, Boonen, Steven, Bartfai, Gyorgy, Casanueva, Felipe F, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Huhtaniemi, Ilpo T, Kula, Krzysztof, Lean, Michael EJ, Pendleton, Neil, Punab, Margus, Silman, Alan J, Vanderschueren, Dirk, and Wu, Frederick CW

Published
2013
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20. Active Vitamin D (1,25-Dihydroxyvitamin D) and Bone Health in Middle-Aged and Elderly Men: The European Male Aging Study (EMAS)

Author

Vanderschueren, Dirk, Pye, Stephen R., OʼNeill, Terence W., Lee, David M., Jans, Ivo, Billen, Jaak, Gielen, Evelien, Laurent, Michaël, Claessens, Frank, Adams, Judith E., Ward, Kate A., Bartfai, Gyorgy, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Wu, Frederick C. W., and Boonen, Steven

Published
2013

21. Erectile dysfunction predicts mortality in middle-aged and older men independent of their sex steroid status.

Author

Antonio, Leen, Wu, Frederick C W, Moors, Hannes, Matheï, Cathy, Huhtaniemi, Ilpo T, Rastrelli, Giulia, Dejaeger, Marian, O'Neill, Terence W, Pye, Stephen R, Forti, Gianni, Maggi, Mario, Casanueva, Felipe F, Slowikowska-Hilczer, Jolanta, Punab, Margus, Tournoy, Jos, Vanderschueren, Dirk, and Group, the EMAS Study

Subjects
MORTALITY risk factors, SEXUAL dysfunction, IMPOTENCE, CONFIDENCE intervals, TESTOSTERONE, RISK assessment, SEX hormones, INDEPENDENT living, QUESTIONNAIRES, MASS spectrometry, DESCRIPTIVE statistics, MALE reproductive organ diseases, PROPORTIONAL hazards models, HYPOACTIVE sexual desire disorder, SYMPTOMS, OLD age
Abstract

Background erectile dysfunction is associated with mortality, whereas the association between low testosterone (T) and higher mortality remains controversial. Sexual dysfunction and low T often coexist, but the relative importance of sexual symptoms versus low T in predicting mortality is not known. We studied the interrelationships between sex steroids and sexual symptoms with all-cause mortality in a large prospective cohort of European men. Design survival status was assessed in 1,788 community-dwelling men, aged 40–79, who participated in the European Male Ageing Study (EMAS). Sexual symptoms were evaluated via a validated questionnaire (EMAS-SFQ). Sex steroids were measured by mass spectrometry. Cox proportional hazard models were used to study the association between hormones, sexual symptoms and mortality. Results about 420 (25.3%) men died during a mean follow-up of 12.6 ± 3.1 years. Total T levels were similar in both groups, but free T was lower in those who died. Men with three sexual symptoms (erectile dysfunction, reduced morning erections and lower libido) had a higher mortality risk compared with men with none of these symptoms (adjusted hazard ratio (HR) and 95% confidence intervals: 1.75 (1.28–2.40, P  = 0.001)). Particularly, erectile dysfunction and poor morning erections, but not lower libido, were associated with increased mortality (HR 1.40 (1.13–1.74, P  = 0.002), 1.28 (1.04–1.59, P  = 0.023) and 1.12 (0.90–1.39, P  = 0.312), respectively). Further adjusting for total T, free T or oestradiol did not influence the observed risk. Conclusions sexual symptoms, in particular erectile dysfunction, predict all-cause mortality independently of sex steroids and can be an early warning sign of a poor health status. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Characteristics of Androgen Deficiency in Late-Onset Hypogonadism: Results from the European Male Aging Study (EMAS)

Author

Tajar, Abdelouahid, Huhtaniemi, Ilpo T., OʼNeill, Terence W., Finn, Joseph D., Pye, Stephen R., Lee, David M., Bartfai, György, Boonen, Steven, Casanueva, Felipe F. F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Labrie, Fernand, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, and Wu, Frederick C. W.

Published
2012

24. Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study

Author

McBeth, John, Pye, Stephen R, OʼNeill, Terence W, Macfarlane, Gary J, Tajar, Abdelouahid, Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva, Felipe, Finn, Joseph D, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Huhtaniemi, Ilpo T, Kula, Krzysztof, Lean, Michael E, Pendleton, Neil, Punab, Margus, Silman, Alan J, Vanderschueren, Dirk, and Wu, Frederick C

Published
2010
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25. Effect of Polymorphisms in Selected Genes Involved in Pituitary-Testicular Function on Reproductive Hormones and Phenotype in Aging Men

Author

Huhtaniemi, Ilpo T., Pye, Stephen R., Holliday, Kate L., Thomson, Wendy, OʼNeill, Terence W., Platt, Hazel, Payne, Debbie, John, Sally L., Jiang, Min, Bartfai, György, Boonen, Steven, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Silman, Alan J., Vanderschueren, Dirk, Labrie, Fernand, and Wu, Frederick C. W.

Published
2010

26. The European Male Ageing Study (EMAS): design, methods and recruitment

Author

Lee, David M., OʼNeill, Terence W., Pye, Stephen R., Silman, Alan J., Finn, Joseph D., Pendleton, Neil, Tajar, Abdelouahid, Bartfai, Gyorgy, Casanueva, Felipe, Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Punab, Margus, Boonen, Steven, Vanderschueren, Dirk, and Wu, Frederick C. W.

Published
2009

27. Increased Estrogen Rather Than Decreased Androgen Action Is Associated with Longer Androgen Receptor CAG Repeats

Author

Huhtaniemi, Ilpo T., Pye, Stephen R., Limer, Kate L., Thomson, Wendy, OʼNeill, Terence W., Platt, Hazel, Payne, Debbie, John, Sally L., Jiang, Min, Boonen, Steven, Borghs, Herman, Vanderschueren, Dirk, Adams, Judith E., Ward, Kate A., Bartfai, György, Casanueva, Felipe, Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Silman, Alan J., and Wu, Frederick C. W.

Published
2009

31. Influence of Inflammatory Polyarthritis on Quantitative Heel Ultrasound Measurements

Author

Pye Stephen R, Marshall Tarnya, Gaffney Karl, Luben Robert, Khaw Kay-Tee, Silman Alan J, Symmons Deborah PM, and O’Neill Terence W

Subjects
Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background There are few data concerning the impact of inflammatory polyarthritis (IP) on quantitative heel ultrasound (QUS) measurements. The aims of this analysis were i) to determine the influence of IP on QUS measurements at the heel and, ii) among those with IP to determine the influence of disease related factors on these measurements. Methods Men and women aged 16 years and over with recent onset IP were recruited to the Norfolk Arthritis Register (NOAR). Individuals with an onset of joint symptoms between 1989 and 1999 were included in this analysis. At the baseline visit subjects underwent a standardised interview and clinical examination with blood taken for rheumatoid factor. A population-based prospective study of chronic disease (EPIC-Norfolk) independently recruited men and women aged 40 to 79 years from the same geographic area between 1993 and 1997. At a follow up assessment between 1998 and 2000 subjects in EPIC-Norfolk were invited to have quantitative ultrasound measurements of the heel (CUBA-Clinical) performed. We compared speed of sound (SOS) and broadband ultrasound attenuation (BUA), in those subjects recruited to NOAR who had ultrasound measurements performed (as part of EPIC-Norfolk) subsequent to the onset of joint symptoms with a group of age and sex matched non-IP controls who had participated in EPIC-Norfolk. Fixed effect linear regression was used to explore the influence of IP on the heel ultrasound parameters (SOS and BUA) so the association could be quantified as the mean difference in BUA and SOS between cases and controls. In those with IP, linear regression was used to examine the association between these parameters and disease related factors. Results 139 men and women with IP and 278 controls (mean age 63.2 years) were studied. Among those with IP, mean BUA was 76.3 dB/MHz and SOS 1621.8 m/s. SOS was lower among those with IP than the controls (difference = −10.0; 95% confidence interval (CI) –17.4, -2.6) though BUA was similar (difference = −1.2; 95% CI −4.5, +2.1). The difference in SOS persisted after adjusting for body mass index and steroid use. Among those with IP, disease activity as determined by the number of swollen joints at baseline, was associated with a lower SOS. In addition SOS was lower in the subgroup that satisfied the 1987 ACR criteria. By contrast, disease duration, steroid use and HAQ score were not associated with either BUA or SOS. Conclusions In this general population derived cohort of individuals with inflammatory polyarthritis there is evidence from ultrasound of a potentially adverse effect on the skeleton. The effect appears more marked in those with active disease.

Published
2012
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32. Assumptions made when preparing drug exposure data for analysis have an impact on results: An unreported step in pharmacoepidemiology studies

Author

Pye, Stephen R, Sheppard, Thérèse, Joseph, Rebecca M, Lunt, Mark, Girard, Nadyne, Haas, Jennifer S, Bates, David W, Buckeridge, David L, van Staa, Tjeerd P, Tamblyn, Robyn, Dixon, William G, Afd Pharmacoepi & Clinical Pharmacology, and Pharmacoepidemiology and Clinical Pharmacology

Subjects
transparency, reproducibility transparency, pharmacoepidemiology, data preparation
Abstract

PURPOSE: Real-world data for observational research commonly require formatting and cleaning prior to analysis. Data preparation steps are rarely reported adequately and are likely to vary between research groups. Variation in methodology could potentially affect study outcomes. This study aimed to develop a framework to define and document drug data preparation and to examine the impact of different assumptions on results. METHODS: An algorithm for processing prescription data was developed and tested using data from the Clinical Practice Research Datalink (CPRD). The impact of varying assumptions was examined by estimating the association between 2 exemplar medications (oral hypoglycaemic drugs and glucocorticoids) and cardiovascular events after preparing multiple datasets derived from the same source prescription data. Each dataset was analysed using Cox proportional hazards modelling. RESULTS: The algorithm included 10 decision nodes and 54 possible unique assumptions. Over 11 000 possible pathways through the algorithm were identified. In both exemplar studies, similar hazard ratios and standard errors were found for the majority of pathways; however, certain assumptions had a greater influence on results. For example, in the hypoglycaemic analysis, choosing a different variable to define prescription end date altered the hazard ratios (95% confidence intervals) from 1.77 (1.56-2.00) to 2.83 (1.59-5.04). CONCLUSIONS: The framework offers a transparent and efficient way to perform and report drug data preparation steps. Assumptions made during data preparation can impact the results of analyses. Improving transparency regarding drug data preparation would increase the repeatability, reproducibility, and comparability of published results.

Published
2018

33. A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study

Author

Han Thang S, Giwercman Aleksander, Forti Gianni, Finn Joseph D, Casanueva Felipe, Bartfai Gyorgy, Ward Kate A, Adams Judith E, Huhtaniemi Ilpo T, Vanderschueren Dirk, Borghs Herman, Boonen Steven, Pye Stephen R, Thomson Wendy, Roshandel Delnaz, Kula Krzysztof, Lean Michael E, Pendleton Neil, Punab Margus, Silman Alan J, Wu Frederick C, Holliday Kate L, and O'Neill Terence W

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background A number of single nucleotide polymorphisms (SNPs) have been associated with broadband ultrasound attenuation (BUA) and speed of sound (SOS) as measured by quantitative ultrasound (QUS) at the calcaneus in the Framingham 100K genome-wide association study (GWAS) but have not been validated in independent studies. The aim of this analysis was to determine if these SNPs are associated with QUS measurements assessed in a large independent population of European middle-aged and elderly men. The association between these SNPs and bone mineral density (BMD) measured using dual-energy X-ray absorptiometry (DXA) was also tested. Methods Men aged 40-79 years (N = 2960) were recruited from population registers in seven European centres for participation in an observational study of male ageing, the European Male Ageing Study (EMAS). QUS at the calcaneus was measured in all subjects and blood was taken for genetic analysis. Lumbar spine (LS), femoral neck (FN) and total hip (TH) BMD were measured by DXA in a subsample of 620 men in two centres. SNPs associated with BUA or SOS in the Framingham study with p < 10-4 were selected and genotyped using SEQUENOM technology. Linear regression was used to test for the association between SNPs and standardised (SD) bone outcomes under an additive genetic model adjusting for centre. The same direction of effect and p < 0.05 indicated replication. Results Thirty-four of 38 selected SNPs were successfully genotyped in 2377 men. Suggestive evidence of replication was observed for a single SNP, rs3754032, which was associated with a higher SOS (β(SD) = 0.07, p = 0.032) but not BUA (β(SD) = 0.02, p = 0.505) and is located in the 3'UTR of WDR77 (WD repeat domain 77) also known as androgen receptor cofactor p44. A single SNP, rs238358, was associated with BMD at the LS (β(SD) = -0.22, p = 0.014), FN (β(SD) = -0.31,p = 0.001) and TH (β(SD) = -0.36, p = 0.002) in a locus previously associated with LS BMD in large-scale GWAS, incorporating AKAP11 and RANKL. Conclusions We found suggestive evidence of association between a single SNP located in the 3'UTR of WDR77 with calcaneal ultrasound parameters. The majority of SNPs, associated with QUS parameters in the Framingham Study, were not replicated in an independent population sample of European men.

Published
2011
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34. Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMDa) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort

Author

Symmons Deborah PM, Silman Alan J, Gaffney Karl, Marshall Tarnya, Pye Stephen R, and O'Neill Terence W

Subjects
Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background The aim of this analysis was to determine the relative influence of disease and non-disease factors on areal bone mineral density (BMDa) in a primary care based cohort of women with inflammatory polyarthritis. Methods Women aged 16 years and over with recent onset inflammatory polyarthritis were recruited to the Norfolk Arthritis Register (NOAR) between 1990 and 1993. Subjects were examined at both baseline and follow up for the presence of tender, swollen and deformed joints. At the 10th anniversary visit, a sub-sample of women were invited to complete a bone health questionnaire and attend for BMDa (Hologic, QDR 4000). Linear regression was used to examine the association between BMDa with both (i) arthritis-related factors assessed at baseline and the 10th anniversary visit and (ii) standard risk factors for osteoporosis. Adjustments were made for age. Results 108 women, mean age 58.0 years were studied. Older age, decreasing weight and BMI at follow up were all associated with lower BMDa at both the spine and femoral neck. None of the lifestyle factors were linked. Indices of joint damage including 10th anniversary deformed joint count and erosive joint count were the arthritis-related variables linked with a reduction in BMDa at the femoral neck. By contrast, disease activity as determined by the number of tender and or swollen joints assessed both at baseline and follow up was not linked with BMDa at either site. Conclusion Cumulative disease damage was the strongest predictor of reduced femoral bone density. Other disease and lifestyle factors have only a modest influence.

Published
2010
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35. Endocrine determinants of incident sarcopenia in middle-aged and elderly European men

Author

Gielen, Evelien, O'Neill, Terence W, Pye, Stephen R, Adams, Judith E, Wu, Frederick C, Laurent, Michaël R, Claessens, Frank, Ward, Kate A, Boonen, Steven, Bouillon, Roger, Vanderschueren, Dirk, and Verschueren, Sabine

Subjects
Sarcopenia, Prospective, Muscle strength, Muscle mass, Men, Original Articles, human activities, Physical performance
Abstract

BACKGROUND: In men, the long-term consequences of low serum levels of sex steroids, vitamin D metabolites, and insulin-like growth factor 1 (IGF-1) on the evolution of muscle mass, muscle strength, or physical performance are unclear. Moreover, there are no data about the relationship between these hormones and incident sarcopenia defined as low muscle mass and function. The aim of this study was to determine whether the baseline levels of sex hormones, vitamin D metabolites, and IGF-1 predict changes in muscle mass, muscle strength, physical performance, and incident sarcopenia. METHODS: In 518 men aged 40-79 years, recruited for participation in the European Male Ageing Study, total, free, and bioavailable testosterone (T), oestradiol (E), sex hormone-binding globulin, IGF-1, 25-hydroxyvitamin D (25OHD), 1,25-dihydroxyvitamin D (1,25(OH)2D), and parathyroid hormone were assessed at baseline. Appendicular lean mass (aLM), gait speed, and grip strength were measured at baseline and after a mean follow-up of 4.3 years. Sarcopenia was defined by the definition of Baumgartner (relative aLM ≤7.26 kg/m(2)), the International Working Group on Sarcopenia (IWGS), and the European Working Group on Sarcopenia in Older People (EWGSOP). RESULTS: aLM significantly decreased from age 50 years, while gait speed and grip strength significantly decreased from age 70 years. The incidence of sarcopenia by the definitions of Baumgartner, IWGS, and EWGSOP was 8.1%, 3.0%, and 1.6%, respectively. After adjustment for age, centre, body mass index, smoking, and number of comorbidities at baseline, baseline levels of T and vitamin D metabolites were not associated with change in aLM, gait speed, and/or grip strength, while a high baseline level of total E2 was associated with a greater decrease in aLM. In men aged ≥70 years, low IGF-1 was associated with a greater decrease in gait speed. Baseline endocrine variables were not independently associated with an increased risk of incident sarcopenia by any definition. CONCLUSIONS: Low levels of T and 25OHD do not predict loss of muscle mass, gait speed, or grip strength in middle-aged and elderly community-dwelling European men. Low IGF-1 predicts change in gait speed in men aged ≥70 years.

Published
2015
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36. Assumptions made when preparing drug exposure data for analysis have an impact on results: An unreported step in pharmacoepidemiology studies

Author

Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Pye, Stephen R, Sheppard, Thérèse, Joseph, Rebecca M, Lunt, Mark, Girard, Nadyne, Haas, Jennifer S, Bates, David W, Buckeridge, David L, van Staa, Tjeerd P, Tamblyn, Robyn, Dixon, William G, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Pye, Stephen R, Sheppard, Thérèse, Joseph, Rebecca M, Lunt, Mark, Girard, Nadyne, Haas, Jennifer S, Bates, David W, Buckeridge, David L, van Staa, Tjeerd P, Tamblyn, Robyn, and Dixon, William G

Published
2018

38. Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men

Author

Eriksson, Anna L, primary, Perry, John R B, additional, Coviello, Andrea D, additional, Delgado, Graciela E, additional, Ferrucci, Luigi, additional, Hoffman, Andrew R, additional, Huhtaniemi, Ilpo T, additional, Ikram, M Arfan, additional, Karlsson, Magnus K, additional, Kleber, Marcus E, additional, Laughlin, Gail A, additional, Liu, Yongmei, additional, Lorentzon, Mattias, additional, Lunetta, Kathryn L, additional, Mellström, Dan, additional, Murabito, Joanne M, additional, Murray, Anna, additional, Nethander, Maria, additional, Nielson, Carrie M, additional, Prokopenko, Inga, additional, Pye, Stephen R, additional, Raffel, Leslie J, additional, Rivadeneira, Fernando, additional, Srikanth, Priya, additional, Stolk, Lisette, additional, Teumer, Alexander, additional, Travison, Thomas G, additional, Uitterlinden, André G, additional, Vaidya, Dhananjay, additional, Vanderschueren, Dirk, additional, Zmuda, Joseph M, additional, März, Winfried, additional, Orwoll, Eric S, additional, Ouyang, Pamela, additional, Vandenput, Liesbeth, additional, Wu, Frederick C W, additional, de Jong, Frank H, additional, Bhasin, Shalender, additional, Kiel, Douglas P, additional, and Ohlsson, Claes, additional

Published
2018
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39. Lower bone turnover and relative bone deficits in men with metabolic syndrome: a matter of insulin sensitivity? The European Male Ageing Study

Author

Laurent, Michaël, Cook, Michael, Gielen, Evelien, Ward, Kate A, Antonio, Leen, Adams, Judith E, Decallonne, Brigitte, Bartfai, György, Casanueva, Felipe F, Forti, Giani, Giwercman, Aleksander, Huhtaniemi, Ilpo T, Kula, Krzysztof, Lean, Michael EJ, Lee, David M, Pendleton, Neil, Punab, Margus, Claessens, Frank, Wu, Frederick CW, Vanderschueren, Dirk, Pye, Stephen R, O’Neill, Terence W, and EMAS, Group

Subjects
Adult, Male, 0301 basic medicine, musculoskeletal diseases, Aging, medicine.medical_specialty, Bone density, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Bone and Bones, Bone remodeling, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, N-terminal telopeptide, Bone Density, Internal medicine, medicine, Humans, Quantitative computed tomography, Aged, Femoral neck, Metabolic Syndrome, Bone mineral, medicine.diagnostic_test, business.industry, nutritional and metabolic diseases, Middle Aged, medicine.disease, Cross-Sectional Studies, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Hyperglycemia, Bone Remodeling, Insulin Resistance, business, Body mass index
Abstract

UNLABELLED: We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with metabolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits. INTRODUCTION: Metabolic syndrome (MetS) has been associated with lower bone turnover and relative bone mass or strength deficits (i.e. not proportionate to body mass index, BMI), but the relative contributions of MetS components related to insulin sensitivity or obesity to male bone health remain unclear. METHODS: We determined cross-sectional associations of MetS, its components and insulin sensitivity (by homeostatic model assessment-insulin sensitivity (HOMA-S)) using linear regression models adjusted for age, centre, smoking, alcohol, and BMI. Bone turnover markers and heel broadband ultrasound attenuation (BUA) were measured in 3129 men aged 40-79. Two centres measured total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD, n = 527) and performed radius peripheral quantitative computed tomography (pQCT, n = 595). RESULTS: MetS was present in 975 men (31.2 %). Men with MetS had lower β C-terminal cross-linked telopeptide (β-CTX), N-terminal propeptide of type I procollagen (PINP) and osteocalcin (P

Published
2016
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40. Chronic widespread pain is associated with worsening frailty in European men

Author

Wade, Katie F., Lee, DM., McBeth, J., Ravindrarajah, R., Gielen, E., Pye, Stephen R., Vanderschueren, D., Pendleton, Neil, Finn, JD., Bartfai, G., Casanueva, FF., Forti, G., Giwercman, A., Huhtaniemi, IT, Kula, K., Punab, M., Wu, Frederick C. W., and O'Neill, Terence W.

Subjects
EMAS, ageing, pain, frailty, male health, human activities
Abstract

© The Author 2015. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. Background: we hypothesised that chronic widespread pain (CWP), by acting as a potential stressor, may predispose to the development of, or worsening, frailty. Setting: longitudinal analysis within the European Male Ageing Study (EMAS). Participants: a total of 2,736 community-dwelling men aged 40-79. Methods: subjects completed a pain questionnaire and shaded a manikin, with the presence of CWP defined using the American College of Rheumatology criteria. Physical activity, smoking, alcohol consumption and depression were measured. Repeat assessments took place a median of 4.3 years later. A frailty index (FI) was used, with frail defined as an FI > 0.35. The association between CWP at baseline and the new occurrence of frailty was examined using logistic regression; the association between CWP at baseline and change in FI was examined using negative binomial regression. Results: at baseline, 218 (8.3%) men reported CWP. Of the 2,631 men who were defined as non-frail at baseline, 112 (4.3%) were frail at follow-up; their mean FI was 0.12 (SD 0.1) at baseline and 0.15 (SD 0.1) at follow-up, with a mean change of 0.03 (SD 0.08) P ≤ 0.001. Among men who were non-frail at baseline, those with CWP were significantly more likely to develop frailty. After adjustment for age and centre, compared with those with no pain, those with CWP at baseline had a 70% higher FI at follow-up; these associations remained significant after further adjustment for smoking, body mass index, depression, physical activity and FI at baseline. Conclusion: the presence of CWP is associated with an increased risk of frailty in older European men.

Published
2016
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41. Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study

Author

McCabe, Paul S., Pye, Stephen R., Mc Beth, John, Lee, David M., Tajar, Abdelouahid, Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva Freijo, Felipe, Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C., O’Neill, Terence W., EMAS Study Group, and Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina

Subjects
Chronic Widespread pain, Epidemiology, Depression, Chronic pain, Obesity, Vitamin D
Abstract

Background The association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men. Methods Three thousand three hundred sixty nine men aged 40–79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. At baseline participants underwent assessment of lifestyle, health factors, physical characteristics and gave a fasting blood sample. The occurrence of pain was assessed at baseline and follow up (a mean of 4.3 years later) by shading painful sites on a body manikin. The presence of CWP was determined using the ACR criteria for fibromyalgia. Serum 25-hydroxyvitamin D (25-(OH) D) was assessed by radioimmunoassay. Logistic regression was used to determine the relationship between baseline vitamin D levels and the new occurrence of CWP. Results Two thousand three hundred thirteen men, mean age 58.8 years (SD = 10.6), had complete pain and vitamin data available and contributed to this analysis. 151 (6.5 %) developed new CWP at follow up and 577 (24.9 %) were pain free at both time points, the comparator group. After adjustment for age and centre, physical performance and number of comorbidities, compared to those in upper quintile of 25-(OH) D ( ≥36.3 ng/mL), those in the lowest quintile (

Published
2016

42. Influenza and Pneumococcal Vaccination Uptake in Patients with Rheumatoid Arthritis Treated with Immunosuppressive Therapy in the UK: A Retrospective Cohort Study Using Data from the Clinical Practice Research Datalink

Author

Costello, Ruth, Winthrop, Kevin, Pye, Stephen R, Brown, Benjamin, and Dixon, William G

Subjects
lcsh:R, lcsh:Medicine, lcsh:Q, lcsh:Science
Abstract

Guidelines for the management of rheumatoid arthritis (RA) recommend using influenza and pneumococcal vaccinations to mitigate infection risk. The level of adherence to these guidelines is not well known in the UK. The aims of this study were to describe the uptake of influenza and pneumococcal vaccinations in patients with RA in the UK, to compare the characteristics of those vaccinated to those not vaccinated and to compare vaccination rates across regions of the UK.A retrospective cohort study of adults diagnosed with incident RA and treated with non-biologic immunosuppressive therapy, using data from a large primary care database. For the influenza vaccination, patients were considered unvaccinated on 1st September each year and upon vaccination their status changed to vaccinated. For pneumococcal vaccination, patients were considered vaccinated after their first vaccination until the end of follow-up. Patients were stratified by age 65 at the start of follow-up, given differences in vaccination guidelines for the general population.Overall (N=15,724), 80% patients received at least one influenza vaccination, and 50% patients received a pneumococcal vaccination, during follow-up (mean 5.3 years). Of those aged below 65 years (N=9,969), 73% patients had received at least one influenza vaccination, and 43% patients received at least one pneumococcal vaccination. Of those aged over 65 years (N=5,755), 91% patients received at least one influenza vaccination, and 61% patients had received at least one pneumococcal vaccination. Those vaccinated were older, had more comorbidity and visited the GP more often. Regional differences in vaccination rates were seen with the highest rates in Northern Ireland, and the lowest rates in London.One in five patients received no influenza vaccinations and one in two patients received no pneumonia vaccine over five years of follow-up. There remains significant scope to improve uptake of vaccinations in patients with RA.

Published
2016
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44. Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men

Author

Eendebak, Robert J.A.H., primary, Swiecicka, Agnieszka, additional, Gromski, Piotr S., additional, Pye, Stephen R., additional, O'Neill, Terence W., additional, Marshall, Alan, additional, Keevil, Brian G., additional, Tampubolon, Gindo, additional, Goodacre, Royston, additional, Wu, Frederick C.W., additional, and Rutter, Martin K., additional

Published
2017
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45. Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study

Author

Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, McCabe, Paul S., Pye, Stephen R., Mc Beth, John, Lee, David M., Tajar, Abdelouahid, Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva Freijo, Felipe, Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C., O’Neill, Terence W., EMAS Study Group, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, McCabe, Paul S., Pye, Stephen R., Mc Beth, John, Lee, David M., Tajar, Abdelouahid, Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva Freijo, Felipe, Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C., O’Neill, Terence W., and EMAS Study Group

Abstract

Background The association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men. Methods Three thousand three hundred sixty nine men aged 40–79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. At baseline participants underwent assessment of lifestyle, health factors, physical characteristics and gave a fasting blood sample. The occurrence of pain was assessed at baseline and follow up (a mean of 4.3 years later) by shading painful sites on a body manikin. The presence of CWP was determined using the ACR criteria for fibromyalgia. Serum 25-hydroxyvitamin D (25-(OH) D) was assessed by radioimmunoassay. Logistic regression was used to determine the relationship between baseline vitamin D levels and the new occurrence of CWP. Results Two thousand three hundred thirteen men, mean age 58.8 years (SD = 10.6), had complete pain and vitamin data available and contributed to this analysis. 151 (6.5 %) developed new CWP at follow up and 577 (24.9 %) were pain free at both time points, the comparator group. After adjustment for age and centre, physical performance and number of comorbidities, compared to those in upper quintile of 25-(OH) D ( ≥36.3 ng/mL), those in the lowest quintile (<15.6 ng/mL) were more likely to develop CWP (Odds Ratio [OR] = 1.93; 95 % CI = 1.0-3.6). Further adjustment for BMI (OR = 1.67; 95 % CI = 0.93-3.02) or depression (OR = 1.77; 95 % CI = 0.98-3.21), however rendered the association non-significant. Conclusions Low vitamin D is linked with the new occurrence of CWP, although this may be explained by underlying adverse health factors, particularly obesity and depression.

Published
2016

46. The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men

Author

Eendebak, Robert J A H, primary, Huhtaniemi, Ilpo T, additional, Pye, Stephen R, additional, Ahern, Tomas, additional, O’Neill, Terence W, additional, Bartfai, György, additional, Casanueva, Felipe F, additional, Maggi, Mario, additional, Forti, Gianni, additional, Alston, Robert D, additional, Giwercman, Aleksander, additional, Han, Thang S, additional, Kula, Krzysztof, additional, Lean, Michael E J, additional, Punab, Margus, additional, Pendleton, Neil, additional, Keevil, Brian G, additional, Vanderschueren, Dirk, additional, Rutter, Martin K, additional, Tampubolon, Gindo, additional, Goodacre, Royston, additional, Wu, Frederick C W, additional, and _, _, additional

Published
2016
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47. Frailty and bone health in European men

Author

Cook, Michael J., primary, Oldroyd, Alexander, additional, Pye, Stephen R., additional, Ward, Kate A., additional, Gielen, Evelien, additional, Ravindrarajah, Rathi, additional, Adams, Judith E., additional, Lee, David M., additional, Bartfai, Gyorgy, additional, Boonen, Steven, additional, Casanueva, Felipe, additional, Forti, Gianni, additional, Giwercman, Aleksander, additional, Han, Thang S., additional, Huhtaniemi, Ilpo T., additional, Kula, Krzysztof, additional, Lean, Michael E., additional, Pendleton, Neil, additional, Punab, Margus, additional, Vanderschueren, Dirk, additional, Wu, Frederick C., additional, and O'Neill, Terence W., additional

Published
2016
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50. Low heel ultrasound parameters predict mortality in men: results from the European Male Ageing Study (EMAS).

Author

Pye, Stephen R, Vanderschueren, Dirk, Boonen, Steven, Gielen, Evelien, Adams, Judith E, Ward, Kate A, Lee, David M, Bartfai, György, Casanueva, Felipe F, Finn, Joseph D, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Huhtaniemi, Ilpo T, Kula, Krzysztof, Lean, Michael E, Pendleton, Neil, Punab, Margus, Wu, Frederick C, O'Neill, Terence W, Pye, Stephen R, Vanderschueren, Dirk, Boonen, Steven, Gielen, Evelien, Adams, Judith E, Ward, Kate A, Lee, David M, Bartfai, György, Casanueva, Felipe F, Finn, Joseph D, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Huhtaniemi, Ilpo T, Kula, Krzysztof, Lean, Michael E, Pendleton, Neil, Punab, Margus, Wu, Frederick C, and O'Neill, Terence W

Abstract

low bone mineral density measured by dual-energy x-ray absorptiometry is associated with increased mortality. The relationship between other skeletal phenotypes and mortality is unclear. The aim of this study was to determine the relationship between quantitative heel ultrasound parameters and mortality in a cohort of European men.

Published
2015

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