Search

Your search keyword '"Puy, Robert"' showing total 180 results
Start Over Author "Puy, Robert"
180 results on '"Puy, Robert"'

2. Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials

Author

Lyko, Christina, Blum, Manuel R, Abolhassani, Nazanin, Stuber, Mirah J, Del Giovane, Cinzia, Feller, Martin, Moutzouri, Elisavet, Oberle, Jolanda, Jungo, Katharina T, Collet, Tinh‐Hai, Elzen, Wendy PJ den, Poortvliet, Rosalinde KE, Du Puy, Robert S, Dekkers, Olaf M, Trompet, Stella, Jukema, J Wouter, Aujesky, Drahomir, Quinn, Terry, Westendorp, Rudi, Kearney, Patricia M, Gussekloo, Jacobijn, Van Heemst, Diana, Mooijaart, Simon P, Bauer, Douglas C, and Rodondi, Nicolas

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, Female, Humans, Aged, Male, Thyroxine, Randomized Controlled Trials as Topic, Hypothyroidism, Hormone Replacement Therapy, autoimmune thyroid disease, levothyroxine treatment, subclinical hypothyroidism, Cardiovascular System & Hematology, Clinical sciences
Abstract

BackgroundAntithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothyroidism (SHypo) caused by autoimmune thyroid disease derive more benefits from levothyroxine treatment (LT4).ObjectiveTo determine whether older adults with SHypo and positive antibodies derive more clinical benefits from LT4 than those with negative antibodies.MethodsWe pooled individual participant data from two RCTs, Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism and IEMO 80+. Participants with persistent SHypo were randomly assigned to receive LT4 or placebo. We compared the effects of LT4 versus placebo in participants with and without anti-thyroid peroxidase (TPO) at baseline. The two primary outcomes were 1-year change in Hypothyroid Symptoms and Tiredness scores on the Thyroid-Related Quality-of-Life Patient-Reported Outcome Questionnaire.ResultsAmong 660 participants (54% women) ≥65 years, 188 (28.5%) had positive anti-TPO. LT4 versus placebo on Hypothyroid Symptoms lead to an adjusted between-group difference of -2.07 (95% confidence interval: -6.04 to 1.90) for positive antibodies versus 0.89 (-1.76 to 3.54) for negative antibodies (p for interaction = 0.31). Similarly, there was no treatment effect modification by baseline antibody status for Tiredness scores-adjusted between-group difference 1.75 (-3.60 to 7.09) for positive antibodies versus 1.14 (-1.90 to 4.19) for negative antibodies (p for interaction = 0.98). Positive anti-TPO were not associated with better quality of life, improvement in handgrip strength, or fewer cardiovascular outcomes with levothyroxine treatment.ConclusionsAmong older adults with SHypo, positive antithyroid antibodies are not associated with more benefits on clinical outcomes with LT4.

Published
2022

4. Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST)

Author

Stott, David J, Gussekloo, Jacobijn, Kearney, Patricia M, Rodondi, Nicolas, Westendorp, Rudi GJ, Mooijaart, Simon, Kean, Sharon, Quinn, Terence J, Sattar, Naveed, Hendry, Kirsty, Du Puy, Robert, Den Elzen, Wendy PJ, Poortvliet, Rosalinde KE, Smit, Jan WA, Jukema, J Wouter, Dekkers, Olaf M, Blum, Manuel, Collet, Tinh-Hai, McCarthy, Vera, Hurley, Caroline, Byrne, Stephen, Browne, John, Watt, Torquil, Bauer, Douglas, and Ford, Ian

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Heart Disease, Aging, Behavioral and Social Science, Clinical Research, Cardiovascular, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Metabolic and endocrine, Good Health and Well Being, Aged, Blood Banks, Clinical Protocols, Double-Blind Method, Hormone Replacement Therapy, Humans, Hypothyroidism, Patient Safety, Thyroxine, Subclinical hypothyroidism, Elderly, Randomised controlled trial, Levothyroxine, Quality of life, Thyroid disease, Endocrinology & Metabolism, Clinical sciences
Abstract

BackgroundSubclinical hypothyroidism (SCH) is a common condition in elderly people, defined as elevated serum thyroid-stimulating hormone (TSH) with normal circulating free thyroxine (fT4). Evidence is lacking about the effect of thyroid hormone treatment. We describe the protocol of a large randomised controlled trial (RCT) of Levothyroxine treatment for SCH.MethodsParticipants are community-dwelling subjects aged ≥65 years with SCH, diagnosed by elevated TSH levels (≥4.6 and ≤19.9 mU/L) on a minimum of two measures ≥ three months apart, with fT4 levels within laboratory reference range. The study is a randomised double-blind placebo-controlled parallel group trial, starting with levothyroxine 50 micrograms daily (25 micrograms in subjects

Published
2017

5. Patient-reported satisfaction with thyroid hormone replacement therapy for subclinical hypothyroidism in older adults: A pooled analysis of individual participant data from two randomized controlled trials

Author

Ravensberg, Janneke, primary, Poortvliet, Rosalinde K.E., additional, Du Puy, Robert, additional, Rodondi, Nicolas, additional, Blum, Manuel, additional, Kearney, Patricia, additional, Mc Carthy, Vera J.C., additional, Quinn, Terry, additional, Dekkers, Olaf, additional, Jukema, Wouter, additional, Mooijaart, Simon, additional, and Gussekloo, Jacobijn, additional

Published
2024
Full Text
View/download PDF

6. Incidence and determinants of spontaneous normalization of subclinical hypothyroidism in older adults

Author

van der Spoel, Evie, van Vliet, Nicolien A, Poortvliet, Rosalinde K E, Du Puy, Robert S, den Elzen, Wendy P J, Quinn, Terence J, Stott, David J, Sattar, Naveed, Kearney, Patricia M, Blum, Manuel R, Alwan, Heba, Rodondi, Nicolas, Collet, Tinh-Hai, Westendorp, Rudi G J, Ballieux, Bart E, Jukema, J Wouter, Dekkers, Olaf M, Gussekloo, Jacobijn, Mooijaart, Simon P, van Heemst, Diana, van der Spoel, Evie, van Vliet, Nicolien A, Poortvliet, Rosalinde K E, Du Puy, Robert S, den Elzen, Wendy P J, Quinn, Terence J, Stott, David J, Sattar, Naveed, Kearney, Patricia M, Blum, Manuel R, Alwan, Heba, Rodondi, Nicolas, Collet, Tinh-Hai, Westendorp, Rudi G J, Ballieux, Bart E, Jukema, J Wouter, Dekkers, Olaf M, Gussekloo, Jacobijn, Mooijaart, Simon P, and van Heemst, Diana

Abstract

Context With age, the prevalence of subclinical hypothyroidism rises. However, incidence and determinants of spontaneous normalization remain largely unknown. Objective To investigate incidence and determinants of spontaneous normalization of TSH levels in older adults with subclinical hypothyroidism. Design Pooled data were used from the (1) pretrial population and (2) in-trial placebo group from 2 randomized, double-blind, placebo-controlled trials (Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism Trial and Institute for Evidence-Based Medicine in Old Age thyroid 80-plus thyroid trial). Setting Community-dwelling 65+ adults with subclinical hypothyroidism from the Netherlands, Switzerland, Ireland, and the United Kingdom. Participants The pretrial population (N = 2335) consisted of older adults with biochemical subclinical hypothyroidism, defined as ≥1 elevated TSH measurement (≥4.60 mIU/L) and a free T4 within the laboratory-specific reference range. Individuals with persistent subclinical hypothyroidism, defined as ≥2 elevated TSH measurements ≥3 months apart, were randomized to levothyroxine/placebo, of which the in-trial placebo group (N = 361) was included. Main Outcome Measures Incidence of spontaneous normalization of TSH levels and associations between participant characteristics and normalization. Results In the pretrial phase, TSH levels normalized in 60.8% of participants in a median follow-up of 1 year. In the in-trial phase, levels normalized in 39.9% of participants after 1 year of follow-up. Younger age, female sex, lower initial TSH level, higher initial free T4 level, absence of thyroid peroxidase antibodies, and a follow-up measurement in summer were independent determinants for normalization. Conclusion Because TSH levels spontaneously normalized in a large proportion of older adults with subclinical hypothyroidism, CONTEXT: With age, the prevalence of subclinical hypothyroidism rises. However, incidence and determinants of spontaneous normalization remain largely unknown.OBJECTIVE: To investigate incidence and determinants of spontaneous normalization of thyroid-stimulating hormone (TSH) levels in older adults with subclinical hypothyroidism.DESIGN: Pooled data were used from the (i) pre-trial population, and (ii) in-trial placebo group from two randomized, double-blind, placebo-controlled trials (TRUST and IEMO thyroid 80-plus thyroid trial).SETTING: Community-dwelling 65 + adults with subclinical hypothyroidism from the Netherlands, Switzerland, Ireland, and the United Kingdom.PARTICIPANTS: The pre-trial population (N = 2335) consisted of older adults with biochemical subclinical hypothyroidism, defined as ≥1 elevated TSH measurement (≥4.60 mIU/L) and a free thyroxine (fT4) within the laboratory-specific reference range. Individuals with persistent subclinical hypothyroidism, defined as ≥2 elevated TSH measurements ≥3 months apart, were randomized to levothyroxine/placebo, of which the in-trial placebo group (N = 361) was included.MAIN OUTCOME MEASURES: Incidence of spontaneous normalization of TSH levels and associations between participant characteristics and normalization.RESULTS: In the pre-trial phase, TSH levels normalized in 60.8% of participants in a median follow-up of one year. In the in-trial phase, levels normalized in 39.9% of participants after one year follow-up. Younger age, female sex, lower initial TSH level, higher initial fT4 level, absence of thyroid peroxidase antibodies, and a follow-up measurement in summer were independent determinants for normalization.CONCLUSIONS: Since TSH levels spontaneously normalized in a large proportion of older adults with subclinical hypothyroidism (also after confirmation by repeat measurement), a third measurement may be recommended before considering treatment.

Published
2024

7. Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults

Author

van der Spoel, Evie, primary, van Vliet, Nicolien A, additional, Poortvliet, Rosalinde K E, additional, Du Puy, Robert S, additional, den Elzen, Wendy P J, additional, Quinn, Terence J, additional, Stott, David J, additional, Sattar, Naveed, additional, Kearney, Patricia M, additional, Blum, Manuel R, additional, Alwan, Heba, additional, Rodondi, Nicolas, additional, Collet, Tinh-Hai, additional, Westendorp, Rudi G J, additional, Ballieux, Bart E, additional, Jukema, J Wouter, additional, Dekkers, Olaf M, additional, Gussekloo, Jacobijn, additional, Mooijaart, Simon P, additional, and van Heemst, Diana, additional

Published
2023
Full Text
View/download PDF

13. Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism:A pooled analysis of two randomized controlled trials

Author

Lyko, Christina, Blum, Manuel R., Abolhassani, Nazanin, Stuber, Mirah J., Del Giovane, Cinzia, Feller, Martin, Moutzouri, Elisavet, Oberle, Jolanda, Jungo, Katharina T., Collet, Tinh-Hai, den Elzen, Wendy P. J., Poortvliet, Rosalinde K. E., Du Puy, Robert S., Dekkers, Olaf M., Trompet, Stella, Jukema, J. Wouter, Aujesky, Drahomir, Quinn, Terry, Westendorp, Rudi, Kearney, Patricia M., Gussekloo, Jacobijn, Van Heemst, Diana, Mooijaart, Simon P., Bauer, Douglas C., Rodondi, Nicolas, Lyko, Christina, Blum, Manuel R., Abolhassani, Nazanin, Stuber, Mirah J., Del Giovane, Cinzia, Feller, Martin, Moutzouri, Elisavet, Oberle, Jolanda, Jungo, Katharina T., Collet, Tinh-Hai, den Elzen, Wendy P. J., Poortvliet, Rosalinde K. E., Du Puy, Robert S., Dekkers, Olaf M., Trompet, Stella, Jukema, J. Wouter, Aujesky, Drahomir, Quinn, Terry, Westendorp, Rudi, Kearney, Patricia M., Gussekloo, Jacobijn, Van Heemst, Diana, Mooijaart, Simon P., Bauer, Douglas C., and Rodondi, Nicolas

Abstract

Background Antithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothyroidism (SHypo) caused by autoimmune thyroid disease derive more benefits from levothyroxine treatment (LT4). Objective To determine whether older adults with SHypo and positive antibodies derive more clinical benefits from LT4 than those with negative antibodies. Methods We pooled individual participant data from two RCTs, Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism and IEMO 80+. Participants with persistent SHypo were randomly assigned to receive LT4 or placebo. We compared the effects of LT4 versus placebo in participants with and without anti-thyroid peroxidase (TPO) at baseline. The two primary outcomes were 1-year change in Hypothyroid Symptoms and Tiredness scores on the Thyroid-Related Quality-of-Life Patient-Reported Outcome Questionnaire. Results Among 660 participants (54% women) >= 65 years, 188 (28.5%) had positive anti-TPO. LT4 versus placebo on Hypothyroid Symptoms lead to an adjusted between-group difference of -2.07 (95% confidence interval: -6.04 to 1.90) for positive antibodies versus 0.89 (-1.76 to 3.54) for negative antibodies (p for interaction = 0.31). Similarly, there was no treatment effect modification by baseline antibody status for Tiredness scores-adjusted between-group difference 1.75 (-3.60 to 7.09) for positive antibodies versus 1.14 (-1.90 to 4.19) for negative antibodies (p for interaction = 0.98). Positive anti-TPO were not associated with better quality of life, improvement in handgrip strength, or fewer cardiovascular outcomes with levothyroxine treatment. Conclusions Among older adults with SHypo, positive antithyroid antibodies are not associated with more benefits on clinical outcomes with LT4.

Published
2022

14. Phenotypic Distinctions Between Omega-5-Gliadin Allergy and Peanut Allergy: Clinical Profile, Reaction Rates and Triggers, and Quality of Life

Author

Zubrinich,Celia M, Puy,Robert M, O'Hehir,Robyn E, Hew,Mark, Zubrinich,Celia M, Puy,Robert M, O'Hehir,Robyn E, and Hew,Mark

Abstract

Celia M Zubrinich,1,2 Robert M Puy,3 Robyn E O’Hehir,1,3 Mark Hew1,2 1Allergy, Asthma & Clinical Immunology, Alfred Health, Melbourne, Victoria, Australia; 2School of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia; 3Allergy and Clinical Immunology Laboratory, Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, AustraliaCorrespondence: Celia M Zubrinich, Email c.zubrinich@alfred.org.auBackground: Different phenotypes of food allergy may exist, exhibiting distinct clinical features, and driven by different pathogenic mechanisms. We compared omega-5-gliadin (O5G) allergy to peanut allergy, focusing on clinical features, reaction rates and triggers, and quality of life (QOL).Methods: We surveyed adults with O5G allergy and peanut allergy regarding their diagnosis, co-morbidities, allergic reactions, and QOL measured by the FAQLQ-AF.Results: We received responses from 43/80 (54%) individuals with O5G allergy and 43/130 (33%) with peanut allergy. Compared to peanut allergic individuals, those with O5G allergy were older at age of onset (37.2 vs 2.5 years, p < 0.001), had fewer additional atopic conditions (0.88 vs 2.93, p < 0.001) or food allergies (0.15 vs 1.86, p < 0.001), and more frequent reactions before diagnosis (1.085 vs 0.29 per month, p < 0.05) Reaction rates improved in both groups following diagnosis. Reactions to peanut were more often triggered by accidental exposure (84% vs 26%, p < 0.001) and being away from home (65% vs 28%, p < 0.001), while reactions to O5G were more often due to deliberate ingestion (30% vs 9%, p < 0.05) or unexpected exercise (35% vs 2%, p < 0.001). Overall QOL score was similar between groups (4.2 in O5G allergy, 4.7 in peanut allergy, p = 0.12), but worse among women and those with additional food allergies.Conclusion: Phenotypic differences between O5G and peanut allergy support the development of different

Published
2022

15. No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism:Pooled Results From 2 Randomized Controlled Trials

Author

Du Puy, Robert S., Poortvliet, Rosalinde K. E., Mooijaart, Simon P., Stott, David J., Quinn, Terry, Sattar, Naveed, Westendorp, Rudi G. J., Kearney, Patricia M., McCarthy, Vera J. C., Byrne, Stephen, Rodondi, Nicolas, Baretella, Oliver, Collet, Tinh-Hai, van Heemst, Diana, Dekkers, Olaf M., Jukema, J. Wouter, Smit, Johannes W. A., Gussekloo, Jacobijn, den Elzen, Wendy P. J., Du Puy, Robert S., Poortvliet, Rosalinde K. E., Mooijaart, Simon P., Stott, David J., Quinn, Terry, Sattar, Naveed, Westendorp, Rudi G. J., Kearney, Patricia M., McCarthy, Vera J. C., Byrne, Stephen, Rodondi, Nicolas, Baretella, Oliver, Collet, Tinh-Hai, van Heemst, Diana, Dekkers, Olaf M., Jukema, J. Wouter, Smit, Johannes W. A., Gussekloo, Jacobijn, and den Elzen, Wendy P. J.

Abstract

Context Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence with advancing age. Objective The aim of this study was to assess whether levothyroxine treatment leads to a rise in hemoglobin levels in older persons with subclinical hypothyroidism. Methods This preplanned combined analysis of 2 randomized controlled trials included community-dwelling persons aged 65 years and older with subclinical hypothyroidism who were randomly assigned to levothyroxine or placebo treatment. The levothyroxine dose was periodically titrated aiming at thyroid stimulating hormone (TSH) level within the reference range, with mock titrations in the placebo group. The main outcome measure was the change in hemoglobin level after 12 months. Results Analyses included 669 participants (placebo n = 337, levothyroxine n = 332) with a median age of 75 years (range, 65-97) and mean baseline hemoglobin of 13.8 +/- 1.3 g/dL. Although levothyroxine treatment resulted in a reduction in TSH from baseline after 12 months of follow-up compared with placebo, the change in hemoglobin level was not different between the levothyroxine and the placebo groups (-0.03 g/dL [95% CI, -0.16 to 0.11]). Similar results were found in stratified analyses including sex, age, or TSH levels. No difference in change of hemoglobin levels after 12 months was identified in 69 participants with anemia at baseline (-0.33 g/dL [95% CI, -0.87 to 0.21]). Conclusion In persons aged 65 years and older with subclinical hypothyroidism, treatment with levothyroxine does not lead to a rise in hemoglobin levels, regardless of the presence of anemia.

Published
2022

17. No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials

Author

Du Puy, Robert S, primary, Poortvliet, Rosalinde K E, additional, Mooijaart, Simon P, additional, Stott, David J, additional, Quinn, Terry, additional, Sattar, Naveed, additional, Westendorp, Rudi G J, additional, Kearney, Patricia M, additional, McCarthy, Vera J C, additional, Byrne, Stephen, additional, Rodondi, Nicolas, additional, Baretella, Oliver, additional, Collet, Tinh-Hai, additional, van Heemst, Diana, additional, Dekkers, Olaf M, additional, Jukema, J Wouter, additional, Smit, Johannes W A, additional, Gussekloo, Jacobijn, additional, and den Elzen, Wendy P J, additional

Published
2022
Full Text
View/download PDF

18. No effect of levothyroxine on hemoglobin in older adults with subclinical hypothyroidism: pooled results from two RCTs

Author

Du Puy, Robert S, Poortvliet, Rosalinde K E, Mooijaart, Simon P, Stott, David J, Quinn, Terry, Sattar, Naveed, Westendorp, Rudi G J, Kearney, Patricia M, McCarthy, Vera J C, Byrne, Stephen, Rodondi, Nicolas, Baretella, Oliver, Collet, Tinh-Hai, van Heemst, Diana, Dekkers, Olaf M, Jukema, J Wouter, Smit, Johannes W A, Gussekloo, Jacobijn, and den Elzen, Wendy P J

Subjects
360 Social problems & social services, 610 Medicine & health
Abstract

CONTEXT Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence numbers with advancing age. OBJECTIVE The aim of this study was to assess whether levothyroxine treatment leads to a rise in hemoglobin levels in older persons with subclinical hypothyroidism. DESIGN A pre-planned combined analysis of two randomized controlled trials. PARTICIPANTS Community-dwelling persons aged 65 years and older with subclinical hypothyroidism. INTERVENTION Participants were randomly assigned to levothyroxine or placebo treatment. The dose of levothyroxine was periodically titrated aiming at thyroid stimulating hormone (TSH) level within the reference range and mock titrations in the placebo group. MAIN OUTCOME MEASURE The main outcome measure was the change in hemoglobin level after 12 months. RESULTS Analyses included 669 participants (placebo n=337, levothyroxine n=332) with a median age of 75 years (range 65 to 97) and mean baseline hemoglobin of 13.8��1.3��g/dL. Although levothyroxine treatment resulted in a reduction in TSH from baseline after 12 months of follow-up compared to placebo, the change in hemoglobin level was not different between the levothyroxine and the placebo groups (-0.03��g/dL [95%CI -0.16 to 0.11]). Similar results were found in stratified analyses including sex, age or TSH levels. No difference in change of hemoglobin levels after 12 months was identified in 69 participants with anemia at baseline (-0.33��g/dL [95% CI -0.87 to 0.21]). CONCLUSIONS In persons aged 65 years and older with subclinical hypothyroidism, treatment with levothyroxine does not lead to a rise in hemoglobin levels, regardless of the presence of anemia.

Published
2022
Full Text
View/download PDF

19. No effect of levothyroxine on hemoglobin in older adults with subclinical hypothyroidism: pooled results from two Randomized Controlled Trials

Author

Du Puy, Robert S, Poortvliet, Rosalinde K E, Mooijaart, Simon P, Stott, David J, Quinn, Terry, Sattar, Naveed, Westendorp, Rudi G J, Kearney, Patricia M, McCarthy, Vera J C, Byrne, Stephen, Rodondi, Nicolas, Baretella, Oliver, Collet, Tinh-Hai, van Heemst, Diana, Dekkers, Olaf M, Jukema, J Wouter, Smit, Johannes W A, Gussekloo, Jacobijn, and den Elzen, Wendy P J

Subjects
ddc:616, Thyroid, Subclinical hypothyroidism, Older adults, Anemia, RCT
Abstract

Context: Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence with advancing age.Objective: The aim of this study was to assess whether levothyroxine treatment leads to a rise in hemoglobin levels in older persons with subclinical hypothyroidism.Methods: This preplanned combined analysis of 2 randomized controlled trials included community-dwelling persons aged 65 years and older with subclinical hypothyroidism who were randomly assigned to levothyroxine or placebo treatment. The levothyroxine dose was periodically titrated aiming at thyroid stimulating hormone (TSH) level within the reference range, with mock titrations in the placebo group. The main outcome measure was the change in hemoglobin level after 12 months.Results: Analyses included 669 participants (placebo n = 337, levothyroxine n = 332) with a median age of 75 years (range, 65-97) and mean baseline hemoglobin of 13.8 ± 1.3 g/dL. Although levothyroxine treatment resulted in a reduction in TSH from baseline after 12 months of follow-up compared with placebo, the change in hemoglobin level was not different between the levothyroxine and the placebo groups (-0.03 g/dL [95% CI, -0.16 to 0.11]). Similar results were found in stratified analyses including sex, age, or TSH levels. No difference in change of hemoglobin levels after 12 months was identified in 69 participants with anemia at baseline (-0.33 g/dL [95% CI, -0.87 to 0.21]).Conclusion: In persons aged 65 years and older with subclinical hypothyroidism, treatment with levothyroxine does not lead to a rise in hemoglobin levels, regardless of the presence of anemia.

Published
2022

21. Sub-Lingual Immunotherapy: World Allergy Organization Position Paper 2009

Author

Canonica, G. Walter, Bousquet, Jean, Casale, Thomas, Lockey, Richard F., Baena-Cagnani, Carlos E., Pawankar, Ruby, Potter, Paul C., Bousquet, Philippe J., Cox, Linda S., Durham, Stephen R., Nelson, Harold S., Passalacqua, Giovanni, Ryan, Dermot P., Brozek, Jan L., Compalati, Enrico, Dahl, Ronald, Delgado, Luis, van Wijk, Roy Gerth, Gower, Richard G., Ledford, Dennis K., Filho, Nelson Rosario, Valovirta, Erkka J., Yusuf, Osman M., Zuberbier, Torsten, Akhanda, Wahiduzzaman, Almarales, Raul Castro, Ansotegui, Ignacio, Bonifazi, Floriano, Ceuppens, Jan, Chivato, Tomás, Dimova, Darina, Dumitrascu, Diana, Fontana, Luigi, Katelaris, Constance H., Kaulsay, Ranbir, Kuna, Piotr, Larenas-Linnemann, Désirée, Manoussakis, Manolis, Nekam, Kristof, Nunes, Carlos, O'Hehir, Robyn, Olaguibel, José M., Onder, Nerin Bahceciler, Park, Jung Won, Priftanji, Alfred, Puy, Robert, Sarmiento, Luis, Scadding, Glenis, Schmid-Grendelmeier, Peter, Seberova, Ester, Sepiashvili, Revaz, Solé, Dírceu, Togias, Alkis, Tomino, Carlo, Toskala, Elina, Van Beever, Hugo, and Vieths, Stefan

Published
2009
Full Text
View/download PDF

22. Diagnostic value of a medical algorithm for investigation of perioperative hypersensitivity reactions.

Author

Sverrild, Asger, Carruthers, John, Murthee, Kavitha Garuna, Moore, Alice, O'Hehir, Robyn Elizabeth, Puy, Robert, Hew, Mark, and Zubrinich, Celia

Subjects
URTICARIA, SKIN tests, NEUROMUSCULAR blocking agents, SYMPTOMS, ALLERGIES, TRYPTASE
Abstract

Background: Evaluation of perioperative hypersensitivity (POH) is challenging, and accurate screening tools are needed to optimize the diagnostic process. We aimed to assess and validate the diagnostic value of a published algorithm (using tryptase and clinical presentation) to identify appropriate individuals for further testing for IgE‐mediated POH. Methods: We analysed the clinical presentation (tryptase elevation, cardiovascular, respiratory, skin involvement) of patients proceeding to testing for possible IgE‐mediated POH at a single tertiary referral centre, relative to subsequent skin testing and specific IgE results. Clinical presentations by drug class were also determined. Results: In 293 consecutive patients, the use of a published algorithm based on one or more of; (i) defined increase in serum tryptase, (ii) involvement of at least two‐organ systems, or (iii) presentation with new urticaria and/or angioedema; was highly sensitive [98.8% (CI95: 95.7–99.9%)] but less specific [34.6% (CI95: 25.7–44.4%)] in identifying patients testing positive on skin testing and/or specific IgE. Presentation with cardiovascular symptoms was also sensitive [89.8%(CI95: 84.2–94.0%)], while the combination of respiratory symptoms and increased tryptase was most specific [85.9%(CI95:76.6–92.5%)]. Respiratory involvement was more common in neuromuscular blocking agent allergy, while urticaria/angioedema was more common in antibiotic allergy. Conclusion: The published algorithm (of tryptase rise, two‐organ involvement or new urticaria/angioedema) is highly sensitive, and appropriate as a screening tool to identify patients suitable for testing for IgE‐mediated POH. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

25. Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism

Author

Wildisen, Lea, Feller, Martin, Del Giovane, Cinzia, Moutzouri, Elisavet, Du Puy, Robert S., Mooijaart, Simon P., Collet, Tinh-Hai, Poortvliet, Rosalinde K. E., Kearney, Patricia, Quinn, Terence J., Klöppel, Stefan, Bauer, Douglas C., Peeters, Robin P., Westendorp, Rudi, Aujesky, Drahomir, Gussekloo, Jacobijn, and Rodondi, Nicolas

Subjects
ddc:616
Abstract

Importance: Previous trials on the effect of levothyroxine on depressive symptom scores in patients with subclinical hypothyroidism were limited by small sample sizes (N = 57 to 94) and potential biases.Objective: To assess the effect of levothyroxine on the development of depressive symptoms in older adults with subclinical hypothyroidism in the largest trial on this subject and to update a previous meta-analysis including the results from this study.Design, setting, and participants: This predefined ancillary study analyzed data from participants in the Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism (TRUST) trial, a double-blind, randomized, placebo-controlled, parallel-group clinical trial conducted from April 2013 to October 31, 2016. The TRUST trial included adults aged 65 years or older diagnosed with subclinical hypothyroidism, defined as the presence of persistently elevated thyroid-stimulating hormone (TSH) levels (4.6-19.9 mIU/L) with free thyroxine (T4) within the reference range. Participants were identified from clinical and general practitioner laboratory databases and recruited from the community in Switzerland, the Netherlands, Ireland, and the UK. This ancillary study included a subgroup of 472 participants from the Netherlands and Switzerland; after exclusions, a total of 427 participants (211 randomized to levothyroxine and 216 to placebo) were analyzed. This analysis was conducted from December 1, 2019, to September 1, 2020.

Published
2021

26. Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials

Author

Zijlstra, Laurien E., primary, Jukema, J. Wouter, additional, Westendorp, Rudi G. J., additional, Du Puy, Robert S., additional, Poortvliet, Rosalinde K. E., additional, Kearney, Patricia M., additional, O’Keeffe, Linda, additional, Dekkers, Olaf M., additional, Blum, Manuel R., additional, Rodondi, Nicolas, additional, Collet, Tinh-Hai, additional, Quinn, Terence J., additional, Sattar, Naveed, additional, Stott, David J., additional, Trompet, Stella, additional, den Elzen, Wendy P. J., additional, Gussekloo, Jacobijn, additional, and Mooijaart, Simon P., additional

Published
2021
Full Text
View/download PDF

27. Evaluation of Diagnosis and Management of Omega-5-Gliadin Allergy: A Retrospective Survey

Author

Zubrinich,Celia, Puy,Robert, O'Hehir,Robyn, Hew,Mark, Zubrinich,Celia, Puy,Robert, O'Hehir,Robyn, and Hew,Mark

Abstract

Celia Zubrinich,1,2 Robert Puy,1,3 Robyn O’Hehir,1,3 Mark Hew1,2 1Allergy, Asthma & Clinical Immunology, Alfred Health, Melbourne, Victoria, Australia; 2School of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia; 3Allergy, Immunology and Respiratory Medicine, Central Clinical School, Monash University, Melbourne, Victoria, AustraliaCorrespondence: Celia Zubrinich Email c.zubrinich@alfred.org.auBackground: Allergy to the omega-5-gliadin component of gluten (O-5-G allergy) often manifests when wheat ingestion is followed by a co-factor, usually exercise. There is no established best approach to management.Objective: We sought to identify the beneficial effects, firstly of establishing a firm diagnosis, and secondly of stringent management, either by avoiding gluten ingestion altogether or separating it temporally from exercise by at least 4 hours. We also determined how frequently patients adhered to their physicians’ clinical recommendations.Methods: We undertook a survey of individuals diagnosed with O-5-G allergy at our institution over 8 years, who had a consistent clinical history and confirmatory laboratory evidence.Results: Of 80 eligible individuals, 43 responded (54%). Symptoms began in adulthood for all bar one, and concurrent asthma and eczema was uncommon (9% prevalence, respectively). Median time to diagnosis was 2 years. Achieving a diagnosis reduced the rate of reactions (0.35 per month vs 1.085 reactions per month, p=0.029). Many patients (10/43) did not adhere to the recommended stringent approach, to either avoid wheat/gluten or separate food and exercise by 4 hours. However, those adopting a stringent approach had a substantially lower risk of recurrent allergic reaction (0.22 per month vs 0.74 per month, p=0.004).Conclusion: The epidemiology of O-5-G allergy implies pathogenic mechanisms potentially distinct from those of childhood-onset food allergy. Accurate diagnosis impro

Published
2021

28. Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism:Pooled Individual Results of Two Randomised Controlled Trials

Author

Zijlstra, Laurien E., Jukema, J. Wouter, Westendorp, Rudi G. J., Du Puy, Robert S., Poortvliet, Rosalinde K. E., Kearney, Patricia M., O'Keeffe, Linda, Dekkers, Olaf M., Blum, Manuel R., Rodondi, Nicolas, Collet, Tinh-Hai, Quinn, Terence J., Sattar, Naveed, Stott, David J., Trompet, Stella, den Elzen, Wendy P. J., Gussekloo, Jacobijn, Mooijaart, Simon P., Zijlstra, Laurien E., Jukema, J. Wouter, Westendorp, Rudi G. J., Du Puy, Robert S., Poortvliet, Rosalinde K. E., Kearney, Patricia M., O'Keeffe, Linda, Dekkers, Olaf M., Blum, Manuel R., Rodondi, Nicolas, Collet, Tinh-Hai, Quinn, Terence J., Sattar, Naveed, Stott, David J., Trompet, Stella, den Elzen, Wendy P. J., Gussekloo, Jacobijn, and Mooijaart, Simon P.

Abstract

BackgroundThe cardiovascular effects of treating older adults with subclinical hypothyroidism (SCH) are uncertain. Although concerns have been raised regarding a potential increase in cardiovascular side effects from thyroid hormone replacement, undertreatment may also increase the risk of cardiovascular events, especially for patients with cardiovascular disease (CVD).ObjectiveTo determine the effects of levothyroxine treatment on cardiovascular outcomes in older adults with SCH.MethodsCombined data of two parallel randomised double-blind placebo-controlled trials TRUST (Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial) and IEMO80+ (the Institute for Evidence-Based Medicine in Old Age 80-plus thyroid trial) were analysed as one-stage individual participant data. Participants aged >= 65 years for TRUST (n=737) and >= 80 years for IEMO80+ (n=105) with SCH, defined by elevated TSH with fT4 within the reference range, were included. Participants were randomly assigned to receive placebo or levothyroxine, with titration of the dose until TSH level was within the reference range. Cardiovascular events and cardiovascular side effects of overtreatment (new-onset atrial fibrillation and heart failure) were investigated, including stratified analyses according to CVD history and age.ResultsThe median [IQR] age was 75.0 [69.7-81.1] years, and 448 participants (53.2%) were women. The mean TSH was 6.38 +/- SD 5.7 mIU/L at baseline and decreased at 1 year to 5.66 +/- 3.3 mIU/L in the placebo group, compared with 3.66 +/- 2.1 mIU/L in the levothyroxine group (pConclusionTreatment with levothyroxine did not significantly change the risk of cardiovascular outcomes in older adults with subclinical hypothyroidism, irrespective of a history of cardiovascular disease and age.

Published
2021

29. Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism An Ancillary Study of a Randomized Clinical Trial

Author

Wildisen, Lea, Feller, Martin, Del Giovane, Cinzia, Moutzouri, Elisavet, Du Puy, Robert S., Mooijaart, Simon P., Collet, Tinh-Hai, Poortvliet, Rosalinde K. E., Kearney, Patricia, Quinn, Terence J., Kloppel, Stefan, Bauer, Douglas C., Peeters, Robin P., Westendorp, Rudi, Aujesky, Drahomir, Gussekloo, Jacobijn, Rodondi, Nicolas, Wildisen, Lea, Feller, Martin, Del Giovane, Cinzia, Moutzouri, Elisavet, Du Puy, Robert S., Mooijaart, Simon P., Collet, Tinh-Hai, Poortvliet, Rosalinde K. E., Kearney, Patricia, Quinn, Terence J., Kloppel, Stefan, Bauer, Douglas C., Peeters, Robin P., Westendorp, Rudi, Aujesky, Drahomir, Gussekloo, Jacobijn, and Rodondi, Nicolas

Abstract

IMPORTANCE Previous trials on the effect of levothyroxine on depressive symptom scores in patients with subclinical hypothyroidism were limited by small sample sizes (N = 57 to 94) and potential biases.OBJECTIVE To assess the effect of levothyroxine on the development of depressive symptoms in older adults with subclinical hypothyroidism in the largest trial on this subject and to update a previous meta-analysis including the results from this study.DESIGN, SETTING, AND PARTICIPANTS This predefined ancillary study analyzed data from participants in the Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism (TRUST) trial, a double-blind, randomized, placebo-controlled, parallel-group clinical trial conducted from April 2013 to October 31, 2016. The TRUST trial included adults aged 65 years or older diagnosed with subclinical hypothyroidism, defined as the presence of persistently elevated thyroid-stimulating hormone (TSH) levels (4.6-19.9 mIU/L) with free thyroxine (T4) within the reference range. Participants were identified from clinical and general practitioner laboratory databases and recruited from the community in Switzerland, the Netherlands, Ireland, and the UK. This ancillary study included a subgroup of 472 participants from the Netherlands and Switzerland; after exclusions, a total of 427 participants (211 randomized to levothyroxine and 216 to placebo) were analyzed. This analysis was conducted from December 1, 2019, to September 1, 2020.INTERVENTIONS Randomization to either levothyroxine or placebo.MAIN OUTCOMES AND MEASURES Depressive symptom scores after 12 months measured with the Geriatric Depression Scale (GDS-15), with higher scores indicating more depressive symptoms (minimal clinically important difference = 2).RESULTS A total of 427 participants with subclinical hypothyroidism (mean [SD] age, 74.52 [6.29] years; 239 women [56%]) were included in this analysis. The mean (SD) TS

Published
2021

30. Strongyloides infection as a reversible cause of chronic urticaria

Author

Zubrinich, Celia M, Puy, Robert M, O’Hehir, Robyn E, and Hew, Mark

Subjects
chronic spontaneous urticaria, urticaria, immune system diseases, parasitic diseases, Strongyloides, CSU, Case Series, strongyloidiasis, skin and connective tissue diseases
Abstract

Recurrent urticaria is a frequent presenting complaint in the Allergy Clinic, despite the fact that chronic urticaria is not an IgE-mediated (atopic) condition in most cases. We present four cases assessed over 5 years in our allergy service who were found to have evidence of strongyloidiasis and whose clinical features resolved with standard anti-helminth treatment.

Published
2019

35. Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Author

Bousquet, Jean, Anto, Josep M., Iaccarino, Guido, Czarlewski, Wienczyslawa, Haahtela, Tari, Anto, Aram, Akdis, Cezmi, Blain, Hubert, Canonica, G. Walter, Cardona, Victoria, Cruz, Alvaro A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Larenas-linnemann, Désirée, Mullol, Joaquim, Papadopoulos, Nikos G., Pfaar, Oliver, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Latiff, Amir, Abdullah, Baharudin, Aberer, Werner, Abusada, Nancy, Adcock, Ian, Afani, Alejandro, Agache, Ioana, Aggelidis, Xenofon, Agustin, Jenifer, Akdis, Mübeccel, Al-Ahmad, Mona, Bassam, Abou Al Zahab, Aldrey-Palacios, Oscar, Cuesta, Emilio Alvarez, Alzaabi, Ashraf, Amad, Salma, Ambrocio, Gene, Annesi-Maesano, Isabella, Ansotegui, Ignacio, Anto, Josep, Arshad, Hasan, Artesani, Maria Cristina, Asayag, Estrella, Avolio, Francesca, Azhari, Khuzama, Baiardini, Ilaria, Bajrović, Nissera, Bakakos, Petros, Mongono, Sergio Bakeyala, Balotro-Torres, Christine, Barba, Sergio, Barbara, Cristina, Barbosa, Elsa, Barreto, Bruno, Bartra, Joan, Bateman, Eric D., Battur, Lkhagvaa, Bedbrook, Anna, Barajas, Martín Bedolla, Beghé, Bianca, Bel, Elizabeth, Kheder, Ali Ben, Benson, Mikael, Berghea, Camelia, Bergmann, Karl Christian, Bernstein, David, Bewick, Mike, Bialek, Slawomir, Białoszewski, Artur, Bieber, Thomas, Billo, Nils, Bilo, Maria Beatrice, Bindslev-Jensen, Carsten, Bjermer, Leif, Marciniak, Malgorzata Bochenska, Bond, Christine, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Botskariova, Sofia, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Bousquet, Philippe, Braido, Fulvio, Briggs, Andrew, Brightling, Christopher, Brozek, Jan, Buhl, Roland, Bumbacea, Roxana, Cabañas, María Teresa Burguete, Bush, Andrew, Busse, William W., Buters, Jeroen, Caballero-Fonseca, Fernan, Calderon, Moïses A., Calvo, Mario, Camargos, Paulo, Camuzat, Thierry, Cano, Antonio, Capriles-Hulett, Arnaldo, Caraballo, Luis, Cardona, Vicky, Carlsen, Kai Hakon, Caro, Jorge, Carreon-Asun-cion, Fredelita, Carriazo, Ana Maria, Casale, Thomas, Castor, Mary Ann, Castro, Elizabeth, Cecchi, Lorenzo, Sarabia, Alfonso Cepeda, Chandrasekharan, Ramanathan, Chang, Yoon Suk, Chato-Andeza, Victoria, Chatzi, Lida, Chatzidaki, Christina, Chavannes, Niels H., Chen, Yuzhi, Cheng, Lei, Chivato, Tomas, Chkhartishvili, Ekaterine, Christoff, George, Chrystyn, Henry, Chu, Derek K., Chua, Antonio, Chuchalin, Alexander, Chung, Kian Fan, Cicerán, Alberto, Cingi, Cemal, Ciprandi, Giorgio, Cirule, Ieva, Coelho, Ana Carla, Constantinidis, Jannis, de Sousa, Jaime Correia, Costa, Elisio, Costa, David, Domínguez, María Del Carmen Costa, Coste, André, Cox, Linda, Cullen, John, Custovic, Adnan, Cvetkovski, Biljana, D’amato, Gennaro, Silva, Jane da, Dahl, Ronald, Dahlen, Sven Erik, Daniilidis, Vasilis, Nahhas, Louei Darjazini, Darsow, Ulf, Blay, Frédéric de, Guia, Eloisa De, Santos, Chato de los, Keenoy, Esteban De Manuel, Vries, Govert De, Deleanu, Diana, Demoly, Pascal, Denburg, Judah, Devillier, Philippe, Didier, Alain, Dimou, Maria, Dinh-Xuan, Anh Tuan, Djukanovic, Ratko, Dokic, Dejan, Domínguez Silva, Margarita Gabriela, Douagui, Habib, Douladiris, Nikolaos, Doulaptsi, Maria, Dray, Gérard, Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, Ebo, Didier, Edelbaher, Natalija, Eklund, Patrik, El-Gamal, Yehia, El-Sayed, Zeinab A., El-Sayed, Shereen S., El-Seify, Magda, Emuzyte, Regina, Enecilla, Lourdes, Espinoza, Heidilita, Guillermo, Jesús, Contreras, Espinoza, Farrell, John, Fernandez, Lenora, Wagner, Antje Fink, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean François, Forastiere, Francesco, Pèrez, Jose Miguel Fuentes, Gaerlan–resureccion, Emily, Gaga, Mina, Romero, José Luis Gálvez, Gamkrelidze, Amiran, Garcia, Alexis, Cobas, Cecilia Yvonne García, García Cruz, María de la Luz Hortensia, Gayraud, Jacques, Gemicioglu, Bilun, Genova, Sonya, Gereda, José, Wijk, Roy Gerth van, Gomez, Maximiliano, Diaz, Sandra González, Gotua, Maia, Grigoreas, Christos, Grisle, Ineta, Guidacci, Marta, Guldemond, Nick, Gutter, Zdenek, Guzmán, Antonieta, Halloum, Ramsa, Hamelmann, Eckard, Hammadi, Suleiman, Harvey, Richard, Heinrich, Joachim, Hejjaoui, Adnan, Hellquist-Dahl, Birthe, Velázquez, Luiana Hernández, Hew, Mark, Hossny, Elham, Howarth, Peter, Hrubiško, Martin, Villalobos, Yunuen Rocío Huerta, Humbert, Marc, Hyland, Michael, Ibrahim, Moustafa, Ilyina, Natalia, Irani, Carla, Ispayeva, Zhanat, Jares, Edgardo, Jarvis, Deborah, Jassem, Ewa, Jenko, Klemen, Uscanga, Rubén Darío Jiméneracruz, Johnston, Sebastian, Joos, Guy, Jošt, Maja, Julge, Kaja, Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor, Kalayci, Omer, Kalyoncu, Fuat, Kapsali, Jeni, Kardas, Przemyslaw, Karjalainen, Jussi, Kasala, Carmela A., Katotomichelakis, Michael, Kazi, Bennoor, Keil, Thomas, Keith, Paul, Khaitov, Musa, Khaltaev, Nikolai, Kim, You Young, Kleine-Tebbe, Jorg, Koffi N’Goran, Bernard, Kompoti, Evangelia, Kopač, Peter, Koppelman, Gerard, Jeverica, Anja Koren, Košnik, Mitja, Kostov, Kosta V., Kowalski, Marek L., Kralimarkova, Tanya, Vrščaj, Karmen Kramer, Kraxner, Helga, Kreft, Samo, Kritikos, Vicky, Kudlay, Dmitry, Kull, Inger, Kupczyk, Maciej, Kvedariene, Violeta, Kyriakakou, Marialena, Lalek, Nika, Lane, Stephen, Larenas-Linnemann, Désiree, Lau, Susanne, Lavrut, Jorge, Le, Lan, Lessa, Marcus, Levin, Michael, Li, Jing, Lieberman, Philip, Liotta, Giuseppe, Lipworth, Brian, Liu, Xuandao, Lobo, Rommel, Lodrup Carlsen, Karin C., Lombardi, Carlo, Louis, Renaud, Loukidis, Stelios, Lourenço, Olga, Luna Pech, Jorge A., Madjar, Bojan, Magnan, Antoine, Mahboub, Bassam, Mair, Alpana, Mais, Yassin, van der Zee, Anke Hilse Maitland, Makela, Mika, Makris, Michael, Malling, Hans Jorgen, Mandajieva, Mariana, Manning, Patrick, Manousakis, Manolis, Maragoudakis, Pavlos, Marshall, Gailen, Martins, Pedro, Reza Masjedi, Mohammad, Máspero, Jorge F., Campos, Juan José Matta, Maurer, Marcus, Mavale-Manuel, Sandra, Meço, Cem, Melén, Erik, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Menzies-Gow, Andrew, Merk, Hans, Michel, Jean Pierre, Miculinic, Neven, Midão, Luís, Mihaltan, Florin, Mikael, Kuitunen, Mikos, Nikolaos, Milenkovic, Branislava, Mitsias, Dimitrios, Moalla, Bassem, Moda, Giuliana, Martínez, María Dolores Mogica, Mohammad, Yousser, Moin, Mostafa, Molimard, Mathieu, Momas, Isabelle, Monaco, Alessandro, Montefort, Steve, Mora, Dory, Morais-Almeida, Mario, Mösges, Ralph, Mostafa, Badr Eldin, Münter, Lars, Muraro, Antonella, Murray, Ruth, Mustakov, Tihomir, Naclerio, Robert, Nadif, Rachel, Nakonechna, Alla, Namazova-Baranova, Leyla, Navarro-Locsin, Gretchen, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Nicod, Laurent, Niederberger-Leppin, Verena, Niedoszytko, Marek, Nieto, Antonio, Novellino, Ettore, Nunes, Elizabete, Nyembue, Dieudonné, O’hehir, Robyn, Odjakova, Cvetanka, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Oliver, Brian, Onorato, Gabrielle L., Orru, Maria Pia, Ouédraogo, Solange, Ouoba, Kampadilemba, Paggiaro, Pier Luigi, Pagkalos, Aris, Palaniappan, S. P., Pali-Schöll, Isabella, Palkonen, Susanna, Palmer, Stephen, Bunu, Carmen Panaitescu, Panzner, Petr, Papanikolaou, Vasilis, Papi, Alberto, Paralchev, Bojidar, Paraskevopoulos, Giannis, Park, Hae Sim, Passalacqua, Giovanni, Patella, Vincenzo, Pavord, Ian, Pawankar, Ruby, Pedersen, Soren, Peleve, Susete, Pereira, Ana, Pérez, Tamara, Pham-Thi, Nhân, Pigearias, Bernard, Pin, Isabelle, Piskou, Konstantina, Pitsios, Constantinos, Pitsios, Kostas, Plavec, Davor, Poethig, Dagmar, Pohl, Wolfgang, Susic, Antonija Poplas, Popov, Todor A., Portejoie, Fabienne, Potter, Paul, Poulsen, Lars, Prados-Torres, Alexandra, Prarros, Fotis, Price, David, Prokopakis, Emmanuel, Puy, Robert, Rabe, Klaus, Raciborski, Filip, Ramos, Josephine, Recto, Marysia T., Reda, Shereen M., Regateiro, Frederico, Reider, Norbert, Reitsma, Sietze, Repka-Ramirez, Susana, Rimmer, Janet, Yeverino, Daniela Rivero, Rizzo, José Angelo, Robalo-Cordeiro, Carlos, Roberts, Graham, Roche, Nicolas, González, Mónica Rodríguez, Zagal, Eréndira Rodríguez, Rolland, Christine, Roller-Wirns-berger, Regina, Rodriguez, Miguel Roman, Romano, Antonino, Rombaux, Philippe, Romualdez, Joel, Rosado-Pinto, Jose, Rosario, Nelson, Rosenwasser, Lanny, Rottem, Menachem, Rouadi, Philip, Rovina, Nikoleta, Sinur, Irma Rozman, Ruiz, Mauricio, Segura, Lucy Tania Ruiz, Ryan, Dermot, Sagara, Hironori, Sakai, Daiki, Sakurai, Daiju, Saleh, Wafaa, Salimaki, Johanna, Salina, Husain, Samitas, Konstanti Nos, Coronel, María Guadalupe Sánchez, Sanchez-Borges, Mario, Sanchez-Lopez, Jaime, Sarafoleanu, Codrut, Serpa, Faradiba Sarquis, Sastre-Dominguez, Joaquin, Scadding, Glenis, Scheire, Sophie, Schmid-Grendelmeier, Peter, Schuhl, Juan Francisco, Schunemann, Holger, Schvalbová, Maria, Scichilone, Nicola, Sepúlveda, Cecilia, Serrano, Elie, Sheikh, Aziz, Shields, Mike, Shishkov, Vasil, Siafakas, Nikos, Simeonov, Alexander, Simons, Estelle F., Sisul, Juan Carlos, Sitkauskiene, Brigita, Skrindo, Ingelbjorg, Košak, Tanja Soklič, Solé, Dirceu, Sooronbaev, Talant, Soto-Martinez, Manuel, Sova, Milan, Spertini, François, Spranger, Otto, Stamataki, Sofia, Stefanaki, Lina, Stellato, Cristiana, Stelmach, Rafael, Sterk, Peter, Strandberg, Timo, Stute, Petra, Subramaniam, Abirami, Suppli Ulrik, Charlotte, Sutherland, Michael, Sylvestre, Silvia, Syrigou, Aikaterini, Barata, Luis Taborda, Takovska, Nadejda, Tan, Rachel, Tan, Frances, Tan, Vincent, Tang, Ing Ping, Taniguchi, Masami, Tannert, Line, Tattersall, Jessica, Teixeira, Maria Do Ceu, Thijs, Carel, Thomas, Mike, To, Teresa, Todo-Bom, Ana Maria, Togias, Alkis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Toskala, Elina, Triggiani, Massimo, Triller, Nadja, Triller, Katja, Tsiligianni, Ioanna, Ulmeanu, Ruxandra, Urbancic, Jure, Pereira, Marilyn Urrutia, Vachova, Martina, Valdés, Felipe, Valenta, Rudolf, Rostan, Marylin Valentin, Valero, Antonio, Vallianatou, Mina, Valovirta, Erkka, Eerd, Michiel Van, Ganse, Eric Van, Hage, Marianne van, Vandenplas, Olivier, Vasankari, Tuula, Vassileva, Dafina, Ventura, Teresa, Vera-Munoz, Cécilia, Vicheva, Dilyana, Vichyanond, Pakit, Vidgren, Petra, Viegi, Giovanni, Vogelmeier, Claus, Hertzen, Leena Von, Vontetsianos, Theodoros, Vourdas, Dimitris, Wagenmann, Martin, Walker, Samantha, Wallace, Dana, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Sian, Williams, Dennis, Wilson, Nicola, Woo, Kent, Wright, John, Wroczynski, Piotr, Xepapadaki, Paraskevi, Yakovliev, Plamen, Yamaguchi, Masao, Yan, Kwok, Yap, Yoke Yeow, Yawn, Barbara, Yiallouros, Panayiotis, Yoshihara, Shigemi, Young, Ian, Yusuf, Osman B., Zaidi, Asghar, Zaitoun, Fares, Zar, Heather, Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Zubrinich, Celia, Bousquet, Jean, Anto, Josep M., Iaccarino, Guido, Czarlewski, Wienczyslawa, Haahtela, Tari, Anto, Aram, Akdis, Cezmi, Blain, Hubert, Canonica, G. Walter, Cardona, Victoria, Cruz, Alvaro A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Larenas-linnemann, Désirée, Mullol, Joaquim, Papadopoulos, Nikos G., Pfaar, Oliver, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Latiff, Amir, Abdullah, Baharudin, Aberer, Werner, Abusada, Nancy, Adcock, Ian, Afani, Alejandro, Agache, Ioana, Aggelidis, Xenofon, Agustin, Jenifer, Akdis, Mübeccel, Al-Ahmad, Mona, Bassam, Abou Al Zahab, Aldrey-Palacios, Oscar, Cuesta, Emilio Alvarez, Alzaabi, Ashraf, Amad, Salma, Ambrocio, Gene, Annesi-Maesano, Isabella, Ansotegui, Ignacio, Anto, Josep, Arshad, Hasan, Artesani, Maria Cristina, Asayag, Estrella, Avolio, Francesca, Azhari, Khuzama, Baiardini, Ilaria, Bajrović, Nissera, Bakakos, Petros, Mongono, Sergio Bakeyala, Balotro-Torres, Christine, Barba, Sergio, Barbara, Cristina, Barbosa, Elsa, Barreto, Bruno, Bartra, Joan, Bateman, Eric D., Battur, Lkhagvaa, Bedbrook, Anna, Barajas, Martín Bedolla, Beghé, Bianca, Bel, Elizabeth, Kheder, Ali Ben, Benson, Mikael, Berghea, Camelia, Bergmann, Karl Christian, Bernstein, David, Bewick, Mike, Bialek, Slawomir, Białoszewski, Artur, Bieber, Thomas, Billo, Nils, Bilo, Maria Beatrice, Bindslev-Jensen, Carsten, Bjermer, Leif, Marciniak, Malgorzata Bochenska, Bond, Christine, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Botskariova, Sofia, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Bousquet, Philippe, Braido, Fulvio, Briggs, Andrew, Brightling, Christopher, Brozek, Jan, Buhl, Roland, Bumbacea, Roxana, Cabañas, María Teresa Burguete, Bush, Andrew, Busse, William W., Buters, Jeroen, Caballero-Fonseca, Fernan, Calderon, Moïses A., Calvo, Mario, Camargos, Paulo, Camuzat, Thierry, Cano, Antonio, Capriles-Hulett, Arnaldo, Caraballo, Luis, Cardona, Vicky, Carlsen, Kai Hakon, Caro, Jorge, Carreon-Asun-cion, Fredelita, Carriazo, Ana Maria, Casale, Thomas, Castor, Mary Ann, Castro, Elizabeth, Cecchi, Lorenzo, Sarabia, Alfonso Cepeda, Chandrasekharan, Ramanathan, Chang, Yoon Suk, Chato-Andeza, Victoria, Chatzi, Lida, Chatzidaki, Christina, Chavannes, Niels H., Chen, Yuzhi, Cheng, Lei, Chivato, Tomas, Chkhartishvili, Ekaterine, Christoff, George, Chrystyn, Henry, Chu, Derek K., Chua, Antonio, Chuchalin, Alexander, Chung, Kian Fan, Cicerán, Alberto, Cingi, Cemal, Ciprandi, Giorgio, Cirule, Ieva, Coelho, Ana Carla, Constantinidis, Jannis, de Sousa, Jaime Correia, Costa, Elisio, Costa, David, Domínguez, María Del Carmen Costa, Coste, André, Cox, Linda, Cullen, John, Custovic, Adnan, Cvetkovski, Biljana, D’amato, Gennaro, Silva, Jane da, Dahl, Ronald, Dahlen, Sven Erik, Daniilidis, Vasilis, Nahhas, Louei Darjazini, Darsow, Ulf, Blay, Frédéric de, Guia, Eloisa De, Santos, Chato de los, Keenoy, Esteban De Manuel, Vries, Govert De, Deleanu, Diana, Demoly, Pascal, Denburg, Judah, Devillier, Philippe, Didier, Alain, Dimou, Maria, Dinh-Xuan, Anh Tuan, Djukanovic, Ratko, Dokic, Dejan, Domínguez Silva, Margarita Gabriela, Douagui, Habib, Douladiris, Nikolaos, Doulaptsi, Maria, Dray, Gérard, Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, Ebo, Didier, Edelbaher, Natalija, Eklund, Patrik, El-Gamal, Yehia, El-Sayed, Zeinab A., El-Sayed, Shereen S., El-Seify, Magda, Emuzyte, Regina, Enecilla, Lourdes, Espinoza, Heidilita, Guillermo, Jesús, Contreras, Espinoza, Farrell, John, Fernandez, Lenora, Wagner, Antje Fink, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean François, Forastiere, Francesco, Pèrez, Jose Miguel Fuentes, Gaerlan–resureccion, Emily, Gaga, Mina, Romero, José Luis Gálvez, Gamkrelidze, Amiran, Garcia, Alexis, Cobas, Cecilia Yvonne García, García Cruz, María de la Luz Hortensia, Gayraud, Jacques, Gemicioglu, Bilun, Genova, Sonya, Gereda, José, Wijk, Roy Gerth van, Gomez, Maximiliano, Diaz, Sandra González, Gotua, Maia, Grigoreas, Christos, Grisle, Ineta, Guidacci, Marta, Guldemond, Nick, Gutter, Zdenek, Guzmán, Antonieta, Halloum, Ramsa, Hamelmann, Eckard, Hammadi, Suleiman, Harvey, Richard, Heinrich, Joachim, Hejjaoui, Adnan, Hellquist-Dahl, Birthe, Velázquez, Luiana Hernández, Hew, Mark, Hossny, Elham, Howarth, Peter, Hrubiško, Martin, Villalobos, Yunuen Rocío Huerta, Humbert, Marc, Hyland, Michael, Ibrahim, Moustafa, Ilyina, Natalia, Irani, Carla, Ispayeva, Zhanat, Jares, Edgardo, Jarvis, Deborah, Jassem, Ewa, Jenko, Klemen, Uscanga, Rubén Darío Jiméneracruz, Johnston, Sebastian, Joos, Guy, Jošt, Maja, Julge, Kaja, Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor, Kalayci, Omer, Kalyoncu, Fuat, Kapsali, Jeni, Kardas, Przemyslaw, Karjalainen, Jussi, Kasala, Carmela A., Katotomichelakis, Michael, Kazi, Bennoor, Keil, Thomas, Keith, Paul, Khaitov, Musa, Khaltaev, Nikolai, Kim, You Young, Kleine-Tebbe, Jorg, Koffi N’Goran, Bernard, Kompoti, Evangelia, Kopač, Peter, Koppelman, Gerard, Jeverica, Anja Koren, Košnik, Mitja, Kostov, Kosta V., Kowalski, Marek L., Kralimarkova, Tanya, Vrščaj, Karmen Kramer, Kraxner, Helga, Kreft, Samo, Kritikos, Vicky, Kudlay, Dmitry, Kull, Inger, Kupczyk, Maciej, Kvedariene, Violeta, Kyriakakou, Marialena, Lalek, Nika, Lane, Stephen, Larenas-Linnemann, Désiree, Lau, Susanne, Lavrut, Jorge, Le, Lan, Lessa, Marcus, Levin, Michael, Li, Jing, Lieberman, Philip, Liotta, Giuseppe, Lipworth, Brian, Liu, Xuandao, Lobo, Rommel, Lodrup Carlsen, Karin C., Lombardi, Carlo, Louis, Renaud, Loukidis, Stelios, Lourenço, Olga, Luna Pech, Jorge A., Madjar, Bojan, Magnan, Antoine, Mahboub, Bassam, Mair, Alpana, Mais, Yassin, van der Zee, Anke Hilse Maitland, Makela, Mika, Makris, Michael, Malling, Hans Jorgen, Mandajieva, Mariana, Manning, Patrick, Manousakis, Manolis, Maragoudakis, Pavlos, Marshall, Gailen, Martins, Pedro, Reza Masjedi, Mohammad, Máspero, Jorge F., Campos, Juan José Matta, Maurer, Marcus, Mavale-Manuel, Sandra, Meço, Cem, Melén, Erik, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Menzies-Gow, Andrew, Merk, Hans, Michel, Jean Pierre, Miculinic, Neven, Midão, Luís, Mihaltan, Florin, Mikael, Kuitunen, Mikos, Nikolaos, Milenkovic, Branislava, Mitsias, Dimitrios, Moalla, Bassem, Moda, Giuliana, Martínez, María Dolores Mogica, Mohammad, Yousser, Moin, Mostafa, Molimard, Mathieu, Momas, Isabelle, Monaco, Alessandro, Montefort, Steve, Mora, Dory, Morais-Almeida, Mario, Mösges, Ralph, Mostafa, Badr Eldin, Münter, Lars, Muraro, Antonella, Murray, Ruth, Mustakov, Tihomir, Naclerio, Robert, Nadif, Rachel, Nakonechna, Alla, Namazova-Baranova, Leyla, Navarro-Locsin, Gretchen, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Nicod, Laurent, Niederberger-Leppin, Verena, Niedoszytko, Marek, Nieto, Antonio, Novellino, Ettore, Nunes, Elizabete, Nyembue, Dieudonné, O’hehir, Robyn, Odjakova, Cvetanka, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Oliver, Brian, Onorato, Gabrielle L., Orru, Maria Pia, Ouédraogo, Solange, Ouoba, Kampadilemba, Paggiaro, Pier Luigi, Pagkalos, Aris, Palaniappan, S. P., Pali-Schöll, Isabella, Palkonen, Susanna, Palmer, Stephen, Bunu, Carmen Panaitescu, Panzner, Petr, Papanikolaou, Vasilis, Papi, Alberto, Paralchev, Bojidar, Paraskevopoulos, Giannis, Park, Hae Sim, Passalacqua, Giovanni, Patella, Vincenzo, Pavord, Ian, Pawankar, Ruby, Pedersen, Soren, Peleve, Susete, Pereira, Ana, Pérez, Tamara, Pham-Thi, Nhân, Pigearias, Bernard, Pin, Isabelle, Piskou, Konstantina, Pitsios, Constantinos, Pitsios, Kostas, Plavec, Davor, Poethig, Dagmar, Pohl, Wolfgang, Susic, Antonija Poplas, Popov, Todor A., Portejoie, Fabienne, Potter, Paul, Poulsen, Lars, Prados-Torres, Alexandra, Prarros, Fotis, Price, David, Prokopakis, Emmanuel, Puy, Robert, Rabe, Klaus, Raciborski, Filip, Ramos, Josephine, Recto, Marysia T., Reda, Shereen M., Regateiro, Frederico, Reider, Norbert, Reitsma, Sietze, Repka-Ramirez, Susana, Rimmer, Janet, Yeverino, Daniela Rivero, Rizzo, José Angelo, Robalo-Cordeiro, Carlos, Roberts, Graham, Roche, Nicolas, González, Mónica Rodríguez, Zagal, Eréndira Rodríguez, Rolland, Christine, Roller-Wirns-berger, Regina, Rodriguez, Miguel Roman, Romano, Antonino, Rombaux, Philippe, Romualdez, Joel, Rosado-Pinto, Jose, Rosario, Nelson, Rosenwasser, Lanny, Rottem, Menachem, Rouadi, Philip, Rovina, Nikoleta, Sinur, Irma Rozman, Ruiz, Mauricio, Segura, Lucy Tania Ruiz, Ryan, Dermot, Sagara, Hironori, Sakai, Daiki, Sakurai, Daiju, Saleh, Wafaa, Salimaki, Johanna, Salina, Husain, Samitas, Konstanti Nos, Coronel, María Guadalupe Sánchez, Sanchez-Borges, Mario, Sanchez-Lopez, Jaime, Sarafoleanu, Codrut, Serpa, Faradiba Sarquis, Sastre-Dominguez, Joaquin, Scadding, Glenis, Scheire, Sophie, Schmid-Grendelmeier, Peter, Schuhl, Juan Francisco, Schunemann, Holger, Schvalbová, Maria, Scichilone, Nicola, Sepúlveda, Cecilia, Serrano, Elie, Sheikh, Aziz, Shields, Mike, Shishkov, Vasil, Siafakas, Nikos, Simeonov, Alexander, Simons, Estelle F., Sisul, Juan Carlos, Sitkauskiene, Brigita, Skrindo, Ingelbjorg, Košak, Tanja Soklič, Solé, Dirceu, Sooronbaev, Talant, Soto-Martinez, Manuel, Sova, Milan, Spertini, François, Spranger, Otto, Stamataki, Sofia, Stefanaki, Lina, Stellato, Cristiana, Stelmach, Rafael, Sterk, Peter, Strandberg, Timo, Stute, Petra, Subramaniam, Abirami, Suppli Ulrik, Charlotte, Sutherland, Michael, Sylvestre, Silvia, Syrigou, Aikaterini, Barata, Luis Taborda, Takovska, Nadejda, Tan, Rachel, Tan, Frances, Tan, Vincent, Tang, Ing Ping, Taniguchi, Masami, Tannert, Line, Tattersall, Jessica, Teixeira, Maria Do Ceu, Thijs, Carel, Thomas, Mike, To, Teresa, Todo-Bom, Ana Maria, Togias, Alkis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Toskala, Elina, Triggiani, Massimo, Triller, Nadja, Triller, Katja, Tsiligianni, Ioanna, Ulmeanu, Ruxandra, Urbancic, Jure, Pereira, Marilyn Urrutia, Vachova, Martina, Valdés, Felipe, Valenta, Rudolf, Rostan, Marylin Valentin, Valero, Antonio, Vallianatou, Mina, Valovirta, Erkka, Eerd, Michiel Van, Ganse, Eric Van, Hage, Marianne van, Vandenplas, Olivier, Vasankari, Tuula, Vassileva, Dafina, Ventura, Teresa, Vera-Munoz, Cécilia, Vicheva, Dilyana, Vichyanond, Pakit, Vidgren, Petra, Viegi, Giovanni, Vogelmeier, Claus, Hertzen, Leena Von, Vontetsianos, Theodoros, Vourdas, Dimitris, Wagenmann, Martin, Walker, Samantha, Wallace, Dana, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Sian, Williams, Dennis, Wilson, Nicola, Woo, Kent, Wright, John, Wroczynski, Piotr, Xepapadaki, Paraskevi, Yakovliev, Plamen, Yamaguchi, Masao, Yan, Kwok, Yap, Yoke Yeow, Yawn, Barbara, Yiallouros, Panayiotis, Yoshihara, Shigemi, Young, Ian, Yusuf, Osman B., Zaidi, Asghar, Zaitoun, Fares, Zar, Heather, Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, and Zubrinich, Celia

Abstract

Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.

Published
2020

36. Mechanism of grass-pollen-induced asthma

Author

Suphioglu, Cenk, Singh, Mohan B., Taylor, Philip, Bellomo, Rinaldo, Holmes, Peter, Puy, Robert, and Knox, R.Bruce

Subjects
Pollen -- Health aspects, Asthma -- Environmental aspects, Allergens -- Identification and classification
Published
1992

38. Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism

Author

Mooijaart, Simon P., primary, Du Puy, Robert S., additional, Stott, David J., additional, Kearney, Patricia M., additional, Rodondi, Nicolas, additional, Westendorp, Rudi G. J., additional, den Elzen, Wendy P. J., additional, Postmus, Iris, additional, Poortvliet, Rosalinde K. E., additional, van Heemst, Diana, additional, van Munster, Barbara C., additional, Peeters, Robin P., additional, Ford, Ian, additional, Kean, Sharon, additional, Messow, Claudia-Martina, additional, Blum, Manuel R., additional, Collet, Tinh-Hai, additional, Watt, Torquil, additional, Dekkers, Olaf M., additional, Jukema, J. Wouter, additional, Smit, Johannes W. A., additional, Langhorne, Peter, additional, and Gussekloo, Jacobijn, additional

Published
2019
Full Text
View/download PDF

41. Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism

Author

Mooijaart, Simon P., Du Puy, Robert S., Stott, David J., Kearney, Patricia M., Rodondi, Nicolas, Westendorp, Rudi G. J., den Elzen, Wendy P. J., Postmus, Iris, Poortvliet, Rosalinde K. E., van Heemst, Diana, van Munster, Barbara C., Peeters, Robin P., Ford, Ian, Kean, Sharon, Messow, Claudia-Martina, Blum, Manuel R., Collet, Tinh-Hai, Watt, Torquil, Dekkers, Olaf M., Jukema, J. Wouter, Smit, Johannes W. A., Langhorne, Peter, Gussekloo, Jacobijn, Mooijaart, Simon P., Du Puy, Robert S., Stott, David J., Kearney, Patricia M., Rodondi, Nicolas, Westendorp, Rudi G. J., den Elzen, Wendy P. J., Postmus, Iris, Poortvliet, Rosalinde K. E., van Heemst, Diana, van Munster, Barbara C., Peeters, Robin P., Ford, Ian, Kean, Sharon, Messow, Claudia-Martina, Blum, Manuel R., Collet, Tinh-Hai, Watt, Torquil, Dekkers, Olaf M., Jukema, J. Wouter, Smit, Johannes W. A., Langhorne, Peter, and Gussekloo, Jacobijn

Published
2019

42. Strongyloides infection as a reversible cause of chronic urticaria

Author

Zubrinich,Celia, Puy,Robert, O'Hehir,Robyn, Hew,Mark, Zubrinich,Celia, Puy,Robert, O'Hehir,Robyn, and Hew,Mark

Abstract

Celia M Zubrinich,1 Robert M Puy,1 Robyn E O’Hehir,1,2 Mark Hew1,2 1Department of Allergy, Immunology and Respiratory Medicine, Alfred Health, Melbourne, VIC, Australia; 2Central Clinical School, Monash University, Melbourne, VIC, Australia Abstract: Recurrent urticaria is a frequent presenting complaint in the Allergy Clinic, despite the fact that chronic urticaria is not an IgE-mediated (atopic) condition in most cases. We present four cases assessed over 5 years in our allergy service who were found to have evidence of strongyloidiasis and whose clinical features resolved with standard anti-helminth treatment. Keywords: urticaria, Strongyloides, strongyloidiasis, chronic spontaneous urticaria, CSU

Published
2019

44. Outcomes of Thyroid Dysfunction in People Aged Eighty Years and Older: An Individual Patient Data Meta-Analysis of Four Prospective Studies (Towards Understanding Longitudinal International Older People Studies Consortium).

Author

Du Puy, Robert S., Poortvliet, Rosalinde K.E., Mooijaart, Simon P., den Elzen, Wendy P.J., Jagger, Carol, Pearce, Simon H.S., Arai, Yasumichi, Hirose, Nobuyoshi, Teh, Ruth, Menzies, Oliver, Rolleston, Anna, Kerse, Ngaire, and Gussekloo, Jacobijn

Subjects
*OLDER people, *OLDER patients, *THYROID gland, *COGNITIVE ability, *GERIATRIC Depression Scale
Abstract

Background: Subclinical and overt thyroid dysfunction is easily detectable, often modifiable, and, in younger age groups, has been associated with clinically relevant outcomes. Robust associations in very old persons, however, are currently lacking. This study aimed to investigate the associations between (sub-)clinical thyroid dysfunction and disability in daily living, cognitive function, depressive symptoms, physical function, and mortality in people aged 80 years and older. Methods: Four prospective cohorts participating in the Towards Understanding Longitudinal International older People Studies (TULIPS) consortium were included. We performed a two-step individual participant data meta-analysis on source data from community-dwelling participants aged 80 years and older from the Netherlands, New Zealand, United Kingdom, and Japan. Outcome measures included disability in daily living (disability in activities of daily living [ADL] questionnaires), cognitive function (Mini-Mental State Examination [MMSE]), depressive symptoms (Geriatric Depression Scale [GDS]), physical function (grip strength) at baseline and after 5 years of follow-up, and all-cause five-year mortality. Results: Of the total 2116 participants at baseline (mean age 87 years, range 80–109 years), 105 participants (5.0%) were overtly hypothyroid, 136 (6.4%) subclinically hypothyroid, 1811 (85.6%) euthyroid, 60 (2.8%) subclinically hyperthyroid, and 4 (0.2%) overtly hyperthyroid. Participants with thyroid dysfunction at baseline had nonsignificantly different ADL scores compared with euthyroid participants at baseline and had similar MMSE scores, GDS scores, and grip strength. There was no difference in the change of any of these functional measures in participants with thyroid dysfunction during five years of follow-up. Compared with the euthyroid participants, no 5-year survival differences were identified in participants with overt hypothyroidism (hazard ratio [HR] 1.0, 95% confidence interval [CI 0.6–1.6]), subclinical hypothyroidism (HR 0.9 [CI 0.7–1.2]), subclinical hyperthyroidism (HR 1.1 [CI 0.8–1.7]), and overt hyperthyroidism (HR 1.5 [CI 0.4–5.9]). Results did not differ after excluding participants using thyroid-influencing medication. Conclusions: In community-dwelling people aged 80 years and older, (sub-)clinical thyroid dysfunction was not associated with functional outcomes or mortality and may therefore be of limited clinical significance. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

46. Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study

Author

O Riordan, David, primary, Aubert, Carole Elodie, additional, Walsh, Kieran A, additional, Van Dorland, Anette, additional, Rodondi, Nicolas, additional, Du Puy, Robert S, additional, Poortvliet, Rosalinde K E, additional, Gussekloo, Jacobijn, additional, Sinnott, Carol, additional, Byrne, Stephen, additional, Galvin, Rose, additional, Jukema, J Wouter, additional, Mooijaart, Simon P, additional, Baumgartner, Christine, additional, McCarthy, Vera, additional, Walsh, Elaine K, additional, Collet, Tinh-Hai, additional, Dekkers, Olaf M, additional, Blum, Manuel R, additional, and Kearney, Patricia M, additional

Published
2018
Full Text
View/download PDF

47. The relation between thyroid function and anemia: a pooled analysis of individual participant data

Author

UCL - SSS/IRSS - Institut de recherche santé et société, Wopereis, Daisy M, Du Puy, Robert S, van Heemst, Diana, Walsh, John P, Bremner, Alexandra, Bakker, Stephan J L, Bauer, Douglas C, Cappola, Anne R, Ceresini, Graziano, Degryse, Jean, Dullaart, Robin P F, Feller, Martin, Ferrucci, Luigi, Floriani, Carmen, Franco, Oscar H, Iacoviello, Massimo, Iervasi, Georgio, Imaizumi, Misa, Jukema, J Wouter, Khaw, Kay-Tee, Luben, Robert N, Molinaro, Sabrina, Nauck, Matthias, Patel, Kushang V, Peeters, Robin P, Psaty, Bruce M, Razvi, Salman, Schindhelm, Roger K, van Schoor, Natasja M, Stott, David J, Vaes, Bert, Vanderpump, Mark P J, Völzke, Henry, Westendorp, Rudi G J, Rodondi, Nicolas, Cobbaert, Christa M, Gussekloo, Jacobijn, den Elzen, Wendy P J, UCL - SSS/IRSS - Institut de recherche santé et société, Wopereis, Daisy M, Du Puy, Robert S, van Heemst, Diana, Walsh, John P, Bremner, Alexandra, Bakker, Stephan J L, Bauer, Douglas C, Cappola, Anne R, Ceresini, Graziano, Degryse, Jean, Dullaart, Robin P F, Feller, Martin, Ferrucci, Luigi, Floriani, Carmen, Franco, Oscar H, Iacoviello, Massimo, Iervasi, Georgio, Imaizumi, Misa, Jukema, J Wouter, Khaw, Kay-Tee, Luben, Robert N, Molinaro, Sabrina, Nauck, Matthias, Patel, Kushang V, Peeters, Robin P, Psaty, Bruce M, Razvi, Salman, Schindhelm, Roger K, van Schoor, Natasja M, Stott, David J, Vaes, Bert, Vanderpump, Mark P J, Völzke, Henry, Westendorp, Rudi G J, Rodondi, Nicolas, Cobbaert, Christa M, Gussekloo, Jacobijn, and den Elzen, Wendy P J

Published
2018

48. Additional file 1: of Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST)

Author

Stott, David, Jacobijn Gussekloo, Kearney, Patricia, Rodondi, Nicolas, Westendorp, Rudi, Mooijaart, Simon, Kean, Sharon, Quinn, Terence, Sattar, Naveed, Hendry, Kirsty, Puy, Robert Du, Elzen, Wendy Den, Poortvliet, Rosalinde, Smit, Jan, J. Jukema, Dekkers, Olaf, Blum, Manuel, Tinh-Hai Collet, McCarthy, Vera, Hurley, Caroline, Byrne, Stephen, Browne, John, Watt, Torquil, Bauer, Douglas, and Ford, Ian

Subjects
humanities, 3. Good health
Abstract

Participant consent form for screening. (DOC 79 kb)

Published
2017
Full Text
View/download PDF

49. 7th drug hypersensitivity meeting: part one

Author

Carr, Daniel F., Chung, Wen-Hung, Jenkiins, Rosalind E., Chaponda, Mas, Nwikue, Gospel, Cornejo Castro, Elena M., Antoine, Daniel J., Pirmohamed, Munir, Wuillemin, Natascha, Dina, Dolores, Eriksson, Klara K., Yerly, Daniel, Pavlos, Rebecca, Mckinnin, Elizabeth, Ostrov, David, Peters, Bjoern, Buus, Soren, Koelle, David, Chopra, Abha, Rive, Craig, Redwood, Alec, Restrepo, Susana, Bracey, Austin, Yuan, Jing, Gaudieri, Silvana, Carrington, Mary, Haas, David, Mallal, Simon, Phillips, Elizabeth, De Boer, Douwe, Menheere, Paul, Nieuwhof, Chris, Bons, Judith, Jonsson, Friederike, De Chaisemartin, Luc, Granger, Vanessa, Gillis, Caitlin, Gouel, Aurelie, Neukirch, Catherine, Dib, Fadia, Nicaise, Pascale Roland, Longrois, Dan, Tubach, Florence, Martin, Sylvie, Bruhns, Pierre, Chen, Kai-Lung, Liao, Shu-Ling, Sheen, Yi-Shuan, Cho, Yung-Tsu, Yang, Che-Wen, Liau, Jau-Yu, Chu, Chia-Yu, Aguiar, Rita, Lopes, Anabela, Fernandes, Natália, Viegas, Leonor, Pereira-Barbosa, M. A., Bünter, Antonia, Gupta, Nisha, Petkovic, Tatjana Pecaric, Wirth, Nicole, Pichler, Werner J., Hausmann, Oliver, Yazicioglu, Mehtap, Ozdemir, Pinar G., Ciplak, Gokce, Kaya, Ozkan, Cooke, Peter John, Mota, Inês, Gaspar, Ângela, Benito-Garcia, Filipe, Chambel, Marta, Morais-Almeida, Mário, Marques, Luis, Alcoceba, Eva, Lara, Silvia, Carneiro-Leão, Leonor, Botelho, Carmen, Dias-Castro, Eunice, Cernadas, Josefina R., Nicholls, Katherine, Lay, William, Smith, Olivia, Collins, Christine, Unglik, Gary, Spriggs, Kymble, Auyeung, Priscilla, McComish, Jeremy, Douglass, Jo A., Peter, Jonny G., Potter, Paul, Carolino, Fabrícia, De Castro, Eunice Dias, Moreira, Ana Sofia, Abreu, Carmo, Gomes, Eva, Cardoso, Bárbara Kong, Tomaz, Elza, Correia, Sara, Inácio, Filipe, Arnold, Annabelle, Bear, Natasha, Rueter, Kristina, Gong, Grace, O’Sullivan, Michael, Muthusamy, Saravanan, Noble, Valerie, Lucas, Michaela, Buterleviciute, Neringa, Rudzeviciene, Odilija, May, Sara, Pongdee, Thanai, Park, Miguel, Griguola, Linas, Vinikovas, Arturas, Kašinskaite, Simona, Kvedariene, Violeta, Aktas, Ayse, Rahman, Suheyla, Elbi, Huseyin, Ozyurt, Beyhan Cengiz, Cavkaytar, Ozlem, Karaatmaca, Betul, Cetinkaya, Pinar Gur, Esenboga, Saliha, Sahiner, Umit M., Sekerel, Bulent E., Soyer, Ozge, Zubrinich, Celia, Tong, Bianca, Patel, Mittal, Giles, Michelle, O’Hehir, Robyn, Puy, Robert, Amaral, Luís, Demir, Semra, Gelincik, Asli, Olgac, Muge, Caskun, Raif, Unal, Derya, Colakoglu, Bahauddin, Buyukozturk, Suna, Matute, Olga Vega, Bernad, Amalia, Gastaminza, Gabriel, Madamba, Roselle, Lacasa, Carlos, Goikoetxea, M. J., D’Amelio, Carmen, Rifón, Jose, Martínez, Nicolas, Ferrer, Marta, Ribeiro, Carmelita, Faria, Emília, Frutuoso, Cristina, Barros, Anabela, Lebre, Rosário, Pego, Alice, Bom, Ana Todo, Ensina, Luis Felipe, Aranda, Carolina, Nunes, Ines Camelo, Martins, Ana Maria, Solé, Dirceu, Bavbek, Sevim, Kendirlinan, Resat, Çerçi, Pamir, Tutluer, Seda, Soyyigit, Sadan, Sözener, Zeynep Çelebi, Aydin, Ömür, Gümüsburun, Reyhan, Almeida, Marta, Sai, Kimie, Imatoh, Takuya, Nakamura, Ryosuke, Fukazawa, Chisato, Hinomura, Yasushi, Saito, Yoshiro, Sousa-Pinto, Bernardo, Correia, Cláudia, Gomes, Lídia, Gil-Mata, Sara, Araújo, Luís, Delgado, Luís, Okamoto-Uchida, Yoshimi, Kajinami, Koji, Matsunaga, Kayoko, Aihara, Michiko, Wang, Chuang-Wei, Su, Shih-Chi, Hung, Shuen-Iu, Ho, Hsin-Chun, Yang, Chih-Hsun, Paulmann, Maren, Dunant, Ariane, Mockenhaupt, Maja, Sekula, Peggy, Schumacher, Martin, Kardaun, Sylvia, Naldi, Luigi, Bellón, Teresa, Creamer, Daniel, Haddad, Cynthia, Sassolas, Bruno, Lebrun-Vignes, Bénédicte, Valeyrie-Allanore, Laurence, Roujeau, Jean-Claude, Kremmler, Carmen, Dodiuk-Gad, Roni P., Olteanu, Cristina, Feinstein, Anthony, Hashimoto, Rena, Alhusayen, Raed, Whyte-Croasdaile, Sonia, Finkelstein, Yaron, Burnett, Marjorie, Sade, Shachar, Cartotto, Robert, Jeschke, Marc, Shear, Neil H., Takamura, Naoko, Yamane, Yumiko, Matsukura, Setsuko, Nakamura, Kazuko, Watanabe, Yuko, Yamaguchi, Yukie, Kambara, Takeshi, Ikezawa, Zenro, Chew, Hall, Knezevic, Brittany, Ionmhain, Una Nic, Barraclough, Allison, Anstey, Matthew, Usui, Toru, Meng, Xiaoli, Farrell, John, Whitaker, Paul, Watson, John, French, Neil, Park, Kevin, Naisbitt, Dean, Neves, Ana Castro, Cadinha, Susana, Moreira, Ana, Da Silva, J. P. Moreira, Drvar, Daniela Ledic, Gulin, Sandra Jerkovic, Hadzavdic, Suzana Ljubojevic, Ceovic, Romana, De Francisco, Ana Montoro, De Vicente Jiménez, Talía, Luque, Amelia García, David, Natalia Rosado, Galván, José Mª Mateos, Darlenski, Razvigor, Gulin, Dario, Sikic, Jozica, Habek, Jasna Cerkez, Galic, Edvard, Specht, Philip, Staab, Doris, Mayer, Beate, Roehmel, Jobst, Solovan, Caius, Chiriac, Anca, Djurinec, Paola, Kostovic, Kresimir, Bradamante, Mirna, Almeida, Jose Pedro, Caiado, Joana, Pedro, Elisa, Da Silva, Pedro Canas, Barbosa, Manuel Pereira, Bogas, Gador, Blanca-López, Natalia, Pérez-Alzate, Diana, Doña, Inmaculada, Agúndez, José Augusto, García-Martín, Elena, Cornejo-García, José Antonio, Mayorga, Cristobalina, Torres, María José, Canto, Maria Gabriela, Blanca, Miguel, Aksakal, Sengül, Sin, Aytül Zerrin, Koç, Zeynep Peker, Günsen, Fatma Düsünür, Ardeniz, Ömür, Gökmen, Emine Nihal Mete, Gülbahar, Okan, Kokuludag, Ali, Pérez-Sánchez, Natalia, Salas, María, Salas, Maria, Gomez, Francisca, Barrionuevo, Esther, Andreu, Inmaculada, Miranda, Miguel Ángel, Didžiokaite, Gabija, Gaidej, Olesia, Garcimartin, Maria Isabel, Somoza, Maria Luisa, Bojas, Gador, Cornejo-Garcia, Jose Antonio, Perez, Francisco Javier Ruano, Miranda, Miguel Angel, Jerschow, Elina, Pelletier, Teresa, Ren, Zhen, Hudes, Golda, Sanak, Marek, Morales, Esperanza, Schuster, Victor, Spivack, Simon D, Rosenstreich, David, Erzen, Renato, Silar, Mira, Bajrovic, Nissera, Rijavec, Matija, Zidarn, Mihaela, Korosec, Peter, Castro, Eunice, Al-Ahmad, Mona, Rodriguez, Tito, Azevedo, João Pedro, Tavares, Beatriz, Regateiro, Frederico, Todo-Bom, Ana, Miranda, Pablo Andrés, De La Cruz Hoyos, Bautista, Abuzeid, Waleed, Akbar, Nadeem, Gibber, Marc, Fried, Marvin, Han, Weiguo, Keskin, Taha, Tamayev, Robert, Spivack, Simon D., Boni, Elisa, Russello, Marina, Mauro, Marina, Neto, Marta Ferreira, Brosseron, Lise, Malheiro, Daniela, Barreira, Patrícia, Sprigg, Dustin, Trevenen, Michelle, Seet, Jason, Trubiano, Jason, Smith, William, Jeelall, Yogesh, Vale, Sandra, Loh, Richard, Mclean-Tooke, Andrew, Müller, Sabine, Amstutz, Ursula, Jörg, Lukas, Yawalkar, Nikhil, Krähenbühl, Stephan, Leblanc, Ana, Ribeiro, Laura, Vega, Arantza, Rivas, Raquel Gutierrez, Alonso, Ana, Beitia, Juan Maria, Mateo, Belén, Cárdenas, Remedios, Garcia-Dominguez, Juan Jesus, Strautins, Kaija, James, Ian, Neves, Ana, Do Céu Machado, Maria, Dalgiç, Ceyda Tunakan, Bulut, Gökten, Ardeniz, Fatma Ömür, Hsu, Shao-Hsuan, Ye, Young-Min, Hur, Gyu-Young, Park, Hae-Sim, Kim, Seung-Hyun, Ali, Syed, Hollingsworth, Peter N., Mclean-Tooke, Andrew P. C., Chadly, Zohra, Fredj, Nadia Ben, Aouam, Karim, Romdhane, Haifa Ben, Boughattas, Naceur A., Chaabane, Amel, Salazar, Marina Lluncor, Pola, Beatriz, Fiandor, Ana, Ramírez, Elena, Ortega, Javier Domínguez, Quirce, Santiago, Cabañas, Rosario, Baynova, Krasimira, Labella, Marina, Prados, Manuel, Ramonaite, Agne, Bajoriuniene, Ieva, Sitkauskiene, Brigita, Sakalauskas, Raimundas, Kwon, Jae-Woo, Park, Shinyoung, Silva, Diana, Leão, Leonor Carneiro, Garcimartin, Maria, De La Torre, Maria Vazquez, Pérez, Francisco Javier Ruano, Haroun, Elisa, Diez, Gabriela Canto, Ónodi-Nagy, Katinka, Kinyó, Ágnes, Kemény, Lajos, Bata-Csörgo, Zsuzsanna, Pita, Joana Sofia, Fernandes, Rosa Anita, Moura, Ana, Sousa, Nuno, Loureiro, Carlos, Pfützner, Wolfgang, Marrouche, Nadine, Grattan, Clive, Chen, Yu-En, Chen, Chun-Bing, Hsiao, Yu-Ping, and Ruano, Francisco Javier

Subjects
Pulmonary and Respiratory Medicine, Drug, Allergy, business.industry, media_common.quotation_subject, Immunology, medicine.disease, Meeting Abstracts, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Drug Hypersensitivity Syndrome, 030220 oncology & carcinogenesis, Immunology and Allergy, Medicine, business, media_common
Abstract

Table of contents Oral Abstracts O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir Pirmohamed O2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture? Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel Yerly O3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivity Rebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, David Koelle, Abha Chopra, Craig Rive, Alec Redwood, Susana Restrepo, Austin Bracey, Jing Yuan, Silvana Gaudieri, Mary Carrington, David Haas, Simon Mallal, Elizabeth Phillips O4 Do we need to measure total ige for the interpretation of analytical results of ImmunoCAP dnd 3gAllergy specific IgE? Douwe De Boer, Paul Menheere, Chris Nieuwhof, Judith Bons O5 Neutrophil activation in systemic anaphylaxis: results from the multicentric NASA study Friederike Jonsson, Luc De Chaisemartin, Vanessa Granger, Caitlin Gillis, Aurelie Gouel, Catherine Neukirch, Fadia Dib, Pascale Roland Nicaise, Dan Longrois, Florence Tubach, Sylvie Martin, Pierre Bruhns, NASA Study Group O6 Purpuric drug eruptions due to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for non-small-cell lung cancer (NSCLC): a clinic-pathological study of 32 cases Kai-Lung Chen, Shu-Ling Liao, Yi-Shuan Sheen, Yung-Tsu Cho, Che-Wen Yang, Jau-Yu Liau, Chia-Yu Chu Poster presentations: Poster Walk 1—Anaphylaxis (P01–P09) P1 Anaphylactic reactions during anaesthesia and the perioperative period Rita Aguiar, Anabela Lopes, Natália Fernandes, Leonor Viegas, M. A. Pereira-Barbosa P2 Anaphylaxis to chlorhexidine: is there a cross-reactivity to alexidine? Antonia Bünter, Nisha Gupta, Tatjana Pecaric Petkovic, Nicole Wirth, Werner J. Pichler, Oliver Hausmann P3 Cefotaxime-induced severe anaphylaxis in a neonate Mehtap Yazicioglu, Pinar G. Ozdemir, Gokce Ciplak, Ozkan Kaya P4 Clinical features and diagnosis of anaphylaxis resulting from exposure to chlorhexidine Peter John Cooke P5 Drug-induced anaphylaxis: five-year single-center survey Inês Mota, Ângela Gaspar, Filipe Benito-Garcia, Marta Chambel, Mário Morais-Almeida P6 Intraoperative severe anaphylactic reaction due to patent blue v dye Luis Marques, Eva Alcoceba, Silvia Lara P7 Kounis syndrome in the setting of anaphylaxis to diclofenac Leonor Carneiro-Leão, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas P8 Perioperative anaphylaxis audit: Royal Melbourne Hospital Katherine Nicholls, William Lay, Olivia Smith, Christine Collins, Gary Unglik, Kymble Spriggs, Priscilla Auyeung, Jeremy McComish, Jo A. Douglass P9 Recurrent peri-operative anaphylaxis: a perfect storm Jonny G. Peter, Paul Potter Poster Walk 2: DH regions and patient groups (P10–P19) P10 A rare presentation of amoxicillin allergy in a young child Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas P11 Adverse drug reactions in children: antibiotics or virus? Ana Sofia Moreira, Carmo Abreu, Eva Gomes P12 Allergic reactions in invasive medical procedures Bárbara Kong Cardoso, Elza Tomaz, Sara Correia, Filipe Inácio P13 Antibiotic allergy in children: room for improvement Annabelle Arnold, Natasha Bear, Kristina Rueter, Grace Gong, Michael O’Sullivan, Saravanan Muthusamy, Valerie Noble, Michaela Lucas P14 Drug hypersensitivity reactions in children and results of diagnostic evaluation Neringa Buterleviciute, Odilija Rudzeviciene P15 Nonimmediate cutaneous drug reactions in children: are skin tests required? Ana Sofia Moreira, Carmo Abreu, Eva Gomes P16 Pediatric patients with a history of penicillin allergy and a positive penicillin skin test may not be at an increased risk for multiple drug allergies Sara May, Thanai Pongdee, Miguel Park P17 Proved hypersensitivity to drugs according data of Vilnius University Hospital Santariskiu Klinikos Linas Griguola, Arturas Vinikovas, Simona Kašinskaite, Violeta Kvedariene P18 Self-reported prevalence of drug hypersensitivity reactions among students in Celal Bayar University, Turkey Ayse Aktas, Suheyla Rahman, Huseyin Elbi, Beyhan Cengiz Ozyurt P19 Severe drug hypersensitivity reactions in pediatric age Ozlem Cavkaytar, Betul Karaatmaca, Pinar Gur Cetinkaya, Saliha Esenboga, Umit M. Sahiner, Bulent E. Sekerel, Ozge Soyer Poster Walk 3: Desensitisation (P20–P28) P20 A protocol for desensitisation to valaciclovir Celia Zubrinich, Bianca Tong, Mittal Patel, Michelle Giles, Robyn O’Hehir, Robert Puy P21 A rare case of desensitization to modafinil Josefina Cernadas, Luís Amaral, Fabrícia Carolino P22 A sixteen-day desensitization protocol in delayed type hypersensitivity reactions to oral drugs Semra Demir, Asli Gelincik, Muge Olgac, Raif Caskun, Derya Unal, Bahauddin Colakoglu, Suna Buyukozturk P23 Desensitization to intravenous etoposide using a 12 and a 13-step protocol. Two cases report Olga Vega Matute, Amalia Bernad, Gabriel Gastaminza, Roselle Madamba, Carlos Lacasa, M. J. Goikoetxea, Carmen D’Amelio, Jose Rifón, Nicolas Martínez, Marta Ferrer P24 Drug desensitisation in oncology: the experience of an immunoallergology department for 5 years Carmelita Ribeiro, Emília Faria, Cristina Frutuoso, Anabela Barros, Rosário Lebre, Alice Pego, Ana Todo Bom P25 Filgrastim anaphylaxis: a successful desensitization protocol Luis Amaral, Josefina Cernadas P26 Galsulfase hypersensitivity and desensitization of a mucopolysaccharidosis VI patient Luis Felipe Ensina, Carolina Aranda, Ines Camelo Nunes, Ana Maria Martins, Dirceu Solé P27 Rapid drug desensitization with biologicals: one-center experience with four biologicals Sevim Bavbek, Resat Kendirlinan, Pamir Çerçi, Seda Tutluer, Sadan Soyyigit, Zeynep Çelebi Sözener, Ömür Aydin, Reyhan Gümüsburun P28 Successful desensitization to a high dose of methotrexate in a delayed type hypersensitivity reaction Josefina Cernadas, Leonor Carneiro-Leão, Fabrícia Carolino, Marta Almeida Poster Walk 4: SJS (P29–P38) P29 Assessment of impact of infection on drug-induced severe cutaneous adverse reactions and rhabdomyolysis using the Japanese adverse drug event report database Kimie Sai, Takuya Imatoh, Ryosuke Nakamura, Chisato Fukazawa, Yasushi Hinomura, Yoshiro Saito P30 Characterization of erythema multiforme and severe cutaneous adverse reactions hospitalizations Bernardo Sousa-Pinto, Cláudia Correia, Lídia Gomes, Sara Gil-Mata, Luís Araújo, Luís Delgado P31 Effects of infection on incidence/severity of SJS/TEN and myopathy in Japanese cases analyzed by voluntary case reports Ryosuke Nakamura, Kimie Sai, Takuya Imatoh, Yoshimi Okamoto-Uchida, Koji Kajinami, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito P32 Efficacy of tumor necrosis factor—a antagonists in Stevens–Johnson syndrome and toxic epidermal necrolysis: a randomized controlled trial and immunosuppressive effects evaluation Chuang-Wei Wang, Shih-Chi Su, Shuen-Iu Hung, Hsin-Chun Ho, Chih-Hsun Yang, Wen-Hung Chung P33 Evolution of drug causality in Stevens–Johnson syndrome and toxic epidermal necrolysis in Europe: analysis of 10 years RegiSCAR-Study Maren Paulmann, Ariane Dunant, Maja Mockenhaupt, Peggy Sekula, Martin Schumacher, Sylvia Kardaun, Luigi Naldi, Teresa Bellón, Daniel Creamer, Cynthia Haddad, Bruno Sassolas, Bénédicte Lebrun-Vignes, Laurence Valeyrie-Allanore, Jean-Claude Roujeau P34 Long-term sequelae in patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: a 5-year analysis Maren Paulmann, Carmen Kremmler, Peggy Sekula, Laurence Valeyrie-Allanore, Luigi Naldi, Sylvia Kardaun, Maja Mockenhaupt P35 Major emotional complications and decreased health related quality of life among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis Roni P. Dodiuk-Gad, Cristina Olteanu, Anthony Feinstein, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear P36 Retrospective analysis of Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients: treatment and outcome Naoko Takamura, Yumiko Yamane, Setsuko Matsukura, Kazuko Nakamura, Yuko Watanabe, Yukie Yamaguchi, Takeshi Kambara, Zenro Ikezawa, Michiko Aihara P37 Severe physical complications among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis Roni P. Dodiuk-Gad, Cristina Olteanu, Rena Hashimoto, Hall Chew, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear P38 Stevens–Johnson syndrome/toxic epidermal necrolysis combined with haemophagocytic lymphohistiocytosis: a case report Brittany Knezevic, Una Nic Ionmhain, Allison Barraclough, Michaela Lucas, Matthew Anstey Poster Walk 5: Other organs/unexpected immune reactions (P39–P47) P39 A case report of patient with anti-tuberculosis drug-related severe liver failure Toru Usui, Xiaoli Meng, John Farrell, Paul Whitaker, John Watson, Neil French, Kevin Park, Dean Naisbitt P40 Acute interstitial nephritis induced by ibuprofen Ana Castro Neves, Susana Cadinha, Ana Moreira, J. P. Moreira Da Silva P41 Cetuximab induced acneiform rash—two case reports Daniela Ledic Drvar, Sandra Jerkovic Gulin, Suzana Ljubojevic Hadzavdic, Romana Ceovic P42 Enteropathy associated with losartan Ana Montoro De Francisco, Talía De Vicente Jiménez, Amelia García Luque, Natalia Rosado David, José Mª Mateos Galván P43 Granuloma annulare after therapy with canakinumab Razvigor Darlenski P44 Hypersensitivity eosinophilic myocarditis or acute coronary syndrome? Case report Dario Gulin, Jozica Sikic, Jasna Cerkez Habek, Sandra Jerkovic Gulin, Edvard Galic P45 Piperacillin-induced immune haemolytic anaemia: a severe and frequent complication of antibiotic treatment in patients with cystic fibrosis Philip Specht, Doris Staab, Beate Mayer, Jobst Roehmel P46 Progesterone triggered pemphigus foliaceus: case report Sandra Jerkovic Gulin, Caius Solovan, Anca Chiriac P47 Ramipril: triggered generalized pustular psoriasis Paola Djurinec, Kresimir Kostovic, Mirna Bradamante, Sandra Jerkovic Gulin, Romana Ceovic Poster Walk 6: NSAIDs (P48–P56) P48 Aspirin desensitization in cardiovascular disease—Portuguese experience Jose Pedro Almeida, Joana Caiado, Elisa Pedro, Pedro Canas Da Silva, Manuel Pereira Barbosa P49 Asthma and/or rhinitis to NSAIDs with good tolerance to ASA Gador Bogas, Natalia Blanca-López, Diana Pérez-Alzate, Inmaculada Doña, José Augusto Agúndez, Elena García-Martín, José Antonio Cornejo-García, Cristobalina Mayorga, María José Torres, Gabriela Canto, Miguel Blanca P50 Clinical characteristics of 196 patients with non-steroidal anti-inflammatory drug (NSAIDs) hypersensitivity Sengül Aksakal, Aytül Zerrin Sin, Zeynep Peker Koç, Fatma Düsünür Günsen, Ömür Ardeniz, Emine Nihal Mete Gökmen, Okan Gülbahar, Ali Kokuludag P51 Development of immediate hypersensitivity to several NSAIDs maintaining good tolerance to ASA Natalia Pérez-Sánchez, Natalia Blanca-López, Diana Pérez-Alzate, Gador Bogas, Inmaculada Doña, María Salas, María José Torres, Miguel Blanca, Gabriela Canto P52 Diagnosis of hypersensitivity reactions to paracetamol in a large series of cases Inmaculada Doña, Maria Salas, Francisca Gomez, Natalia Blanca-Lopez, Diana Perez-Alzate, Gador Bogas, Esther Barrionuevo, Maria Jose Torres, Inmaculada Andreu, Miguel Ángel Miranda, Gabriela Canto, Miguel Blanca P53 Hypersensitivity to paracetamol according to the new classification of hypersensitivity to NSAIDs Gabija Didžiokaite, Olesia Gaidej, Simona Kašinskaite, Violeta Kvedariene P54 Ibuprofen and other aryl propionic derivates can induce immediate selective hypersensitivity responses Diana Perez-Alzate, Natalia Blanca-López, Maria Isabel Garcimartin, Inmaculada Doña, Maria Luisa Somoza, Cristobalina Mayorga, Maria Jose Torres, Gador Bojas, Jose Antonio Cornejo-Garcia, Maria Gabriela Canto, Miguel Blanca P55 Subjects developing immediate responses to several NSAIDs can be selective with good tolerance to ASA Natalia Blanca-Lopez, Diana Pérez-Alzate, Francisco Javier Ruano Perez, Inmaculada Doña, Maria Luisa Somoza, Inmaculada Andreu, Miguel Angel Miranda, Cristobalina Mayorga, Maria Jose Torres, Jose Antonio Cornejo-Garcia, Miguel Blanca, Maria Gabriela Canto P56 Utility of low-dose oral aspirin challenges for diagnosis of aspirin exacerbated respiratory disease Elina Jerschow, Teresa Pelletier, Zhen Ren, Golda Hudes, Marek Sanak, Esperanza Morales, Victor Schuster, Simon D. Spivack, David Rosenstreich Poster Walk 7: NSAID 2 (P57–P65) P57 Alternate regulation of cyclooxygenase-2 (COX-2) MRNA expression may predispose patients to aspirin-induced exacerbations Renato Erzen, Mira Silar, Nissera Bajrovic, Matija Rijavec, Mihaela Zidarn, Peter Korosec P58 Anaphylaxis to diclofenac: what about the underlying mechanism? Leonor Carneiro-Leão, Fabrícia Carolino, Luís Amaral, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas P59 COX-2 inhibitors: are they always a safe alternative in hypersensitivity to nonsteroidal anti-inflammatory drugs? Luis Amaral, Fabricia Carolino, Eunice Castro, Josefina Cernadas P60 Management of patients with history of NSAIDs reactions prior to coronary angioplasty Mona Al-Ahmad, Tito Rodriguez P61 Oral drug challenge with non-steroidal anti-inflammatory drug under spirometric control: clinical series of 110 patients João Pedro Azevedo, Emília Faria, Beatriz Tavares, Frederico Regateiro, Ana Todo-Bom P62 Prevalence and incidence of analgesic hypersensitivity reactions in Colombia Pablo Andrés Miranda, Bautista De La Cruz Hoyos P63 Recent endoscopic sinus surgery lessens reactions during aspirin challenge in patients with aspirin exacerbated respiratory disease Teresa Pelletier, Waleed Abuzeid, Nadeem Akbar, Marc Gibber, Marvin Fried, Weiguo Han, Taha Keskin, Robert Tamayev, Golda Hudes, Simon D. Spivack, David Rosenstreich, Elina Jerschow P64 Safe use of imidazole salycilate in a case of multiple NSAIDs induced urticaria-angioedema Elisa Boni, Marina Russello, Marina Mauro P65 Selective hypersensitivity reactions to ibuprofen—seven years experience Marta Ferreira Neto Poster Walk 8: Epidemiological methods (P66–P72) P66 Allopurinol hypersensitivity: a 7-year review Lise Brosseron, Daniela Malheiro, Susana Cadinha, Patrícia Barreira, J. P. Moreira Da Silva P67 Antibiotic allergy labelling is associated with increased hospital readmission rates in Australia Brittany Knezevic, Dustin Sprigg, Michelle Trevenen, Jason Seet, Jason Trubiano, William Smith, Yogesh Jeelall, Sandra Vale, Richard Loh, Andrew Mclean-Tooke, Michaela Lucas P68 Experts’ opinions on severe cutaneous adverse drug reactions-report of a survey from the 9th international congress on cutaneous adverse drug reactions 2015 Roni P. Dodiuk-Gad, Cristina Olteanu, Wen-Hung Chung, Neil H. Shear P69 HLA-A*31-positive AGEP with carbamazepine use and other severe cutaneous adverse drug reactions (SCARs) detected by electronic medical records screening Sabine Müller, Ursula Amstutz, Lukas Jörg, Nikhil Yawalkar, Stephan Krähenbühl P70 Patients with suspected drug allergy: a specific psychological profile? Eunice Dias-Castro, Ana Leblanc, Laura Ribeiro, Josefina R. Cernadas P71 Use of an electronic device and a computerized mathematic algorithm to detect the allergic drug reactions through the analysis of heart rate variability Arantza Vega, Raquel Gutierrez Rivas, Ana Alonso, Juan Maria Beitia, Belén Mateo, Remedios Cárdenas, Juan Jesus Garcia-Dominguez P72 Variation in ERAP influences risk for HLA-B*57:01 positive abacavir hypersensitivity Rebecca Pavlos, Kaija Strautins, Ian James, Simon Mallal, Alec Redwood, Elizabeth Phillips Poster Walk 9: DRESS/AGEP (P73–P81) P73 A clinical case of DRESS syndrome in a child after administration of amoxicillin-clavulanic acid Rita Aguiar, Anabela Lopes, Ana Neves, Maria Do Céu Machado, M. A. Pereira-Barbosa P74 Acute generalized exanthematous pustulosis (AGEP) induced by mesalazine, reliable and oftenly used drug to treat inflammatory bowel disease Ceyda Tunakan Dalgiç, Emine Nihal Mete Gökmen, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Ali Kokuludag, Aytül Zerrin Sin P75 Changes of blood plasmacytoid dendritic cells, myeloid dendritic cells, and basophils during the acute stage of drug reaction with eosinophilia and systemic symptoms (DRESS) and other drug eruptions Shao-Hsuan Hsu, Yung-Tsu Cho, Che-Wen Yang, Kai-Lung Chen, Chia-Yu Chu P76 Characterization of isoniazid/rifampicin-specific t-cell responses in patients with DRESS syndrome Young-Min Ye, Gyu-Young Hur, Hae-Sim Park, Seung-Hyun Kim P77 DRESS syndrome secondary to sulfasalazine with delayed TEN: a case presentation Syed Ali, Michaela Lucas, Peter N. Hollingsworth, Andrew P. C. Mclean-Tooke P78 Drug rash with eosinophilia and systemic symptoms (DRESS) features according to the culprit drug Zohra Chadly, Nadia Ben Fredj, Karim Aouam, Haifa Ben Romdhane, Naceur A. Boughattas, Amel Chaabane P79 Drug reaction with eosinophilia and systemic symptoms induced by allopurinol: not always easy to diagnose Marina Lluncor Salazar, Beatriz Pola, Ana Fiandor, Teresa Bellón, Elena Ramírez, Javier Domínguez Ortega, Santiago Quirce, Rosario Cabañas P80 Drug reaction with eosinophilia and systemic symptoms syndrome induced by two drugs simultaneously: a case report Krasimira Baynova, Marina Labella, Manuel Prados P81 The drug reaction with eosinophilia and systemic symptoms (DRESS) induced by the second-line antituberculosis drugs and Epstein–Barr virus infection Agne Ramonaite, Ieva Bajoriuniene, Brigita Sitkauskiene, Raimundas Sakalauskas Poster Walk 10: Miscellaneous drug hypersensitivity (P82–P91) P82 A case of cycloserine-induced lichenoid drug eruption confirmed with a lymphocatye transformation test Jae-Woo Kwon, Shinyoung Park P83 Allergic reaction to topical eye drops: 5 years’ retrospective study in a drug allergy unit Diana Silva, Leonor Carneiro Leão, Fabricia Carolino, Eunice Castro, Josefina Cernadas P84 Allergy to heparins Diana Perez-Alzate, Natalia Blanca-López, Maria Luisa Somoza Alvarez, Maria Garcimartin, Maria Vazquez De La Torre, Francisco Javier Ruano Pérez, Elisa Haroun, Gabriela Canto Diez P85 Allopurinol-induced adverse drug reactions Katinka Ónodi-Nagy, Ágnes Kinyó, Lajos Kemény, Zsuzsanna Bata-Csörgo P86 Analysis of a population with immediate hypersensitivity to corticosteroids: an 11 year review Joana Sofia Pita, Emília Faria, Rosa Anita Fernandes, Ana Moura, Nuno Sousa, Carmelita Ribeiro, Carlos Loureiro, Ana Todo Bom P87 Anaphylaxis against mivacurium in a 12-months old boy at first-time exposure Wolfgang Pfützner P88 Antihistamine-exacerbated chronic spontaneous urticaria: a paradox? Nadine Marrouche, Clive Grattan P89 Anti-osteoporotic agents-induced cutaneous adverse drug reactions in Asians Yu-En Chen, Chun-Bing Chen, Wen-Hung Chung, Yu-Ping Hsiao, Chia-Yu Chu P90 Diagnosis of allergic reactions to eye drops Maria Vazquez De La Torre, Natalia Blanca-Lopez, Diana Perez-Alzate, Maria Isabel Garcimartin, Francisco Javier Ruano, Maria Luisa Somoza, Elisa Haroun, Gabriela Canto P91 Diagnostic approach in suspected hypersensitivity reactions to corticosteroids Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas

Published
2016

50. Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism

Author

Stott, David J., primary, Rodondi, Nicolas, additional, Kearney, Patricia M., additional, Ford, Ian, additional, Westendorp, Rudi G.J., additional, Mooijaart, Simon P., additional, Sattar, Naveed, additional, Aubert, Carole E., additional, Aujesky, Drahomir, additional, Bauer, Douglas C., additional, Baumgartner, Christine, additional, Blum, Manuel R., additional, Browne, John P., additional, Byrne, Stephen, additional, Collet, Tinh-Hai, additional, Dekkers, Olaf M., additional, den Elzen, Wendy P.J., additional, Du Puy, Robert S., additional, Ellis, Graham, additional, Feller, Martin, additional, Floriani, Carmen, additional, Hendry, Kirsty, additional, Hurley, Caroline, additional, Jukema, J. Wouter, additional, Kean, Sharon, additional, Kelly, Maria, additional, Krebs, Danielle, additional, Langhorne, Peter, additional, McCarthy, Gemma, additional, McCarthy, Vera, additional, McConnachie, Alex, additional, McDade, Mairi, additional, Messow, Martina, additional, O’Flynn, Annemarie, additional, O’Riordan, David, additional, Poortvliet, Rosalinde K.E., additional, Quinn, Terence J, additional, Russell, Audrey, additional, Sinnott, Carol, additional, Smit, Jan W.A., additional, Van Dorland, H. Anette, additional, Walsh, Kieran A., additional, Walsh, Elaine K., additional, Watt, Torquil, additional, Wilson, Robbie, additional, and Gussekloo, Jacobijn, additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results