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1. Outcome of relapsed/refractory acute promyelocytic leukaemia in children, adolescents and young adult patients — a 25-year Italian experience

Author

Testi, A, Mohamed, S, Diverio, D, Piciocchi, A, Menna, G, Rizzari, C, Timeus, F, Micalizzi, C, Lo Nigro, L, Santoro, N, Masetti, R, Micheletti, M, Ziino, O, Onofrillo, D, Ladogana, S, Putti, C, Pierani, P, Arena, V, Zecca, M, Foa, R, Locatelli, F, Testi A. M., Mohamed S., Diverio D., Piciocchi A., Menna G., Rizzari C., Timeus F., Micalizzi C., Lo Nigro L., Santoro N., Masetti R., Micheletti M. V., Ziino O., Onofrillo D., Ladogana S., Putti C., Pierani P., Arena V., Zecca M., Foa R., Locatelli F., Testi, A, Mohamed, S, Diverio, D, Piciocchi, A, Menna, G, Rizzari, C, Timeus, F, Micalizzi, C, Lo Nigro, L, Santoro, N, Masetti, R, Micheletti, M, Ziino, O, Onofrillo, D, Ladogana, S, Putti, C, Pierani, P, Arena, V, Zecca, M, Foa, R, Locatelli, F, Testi A. M., Mohamed S., Diverio D., Piciocchi A., Menna G., Rizzari C., Timeus F., Micalizzi C., Lo Nigro L., Santoro N., Masetti R., Micheletti M. V., Ziino O., Onofrillo D., Ladogana S., Putti C., Pierani P., Arena V., Zecca M., Foa R., and Locatelli F.

Published
2021

2. Outcome of relapsed/refractory acute promyelocytic leukaemia in children, adolescents and young adult patients — a 25-year Italian experience

Author

Testi, A. M., Mohamed, S., Diverio, D., Piciocchi, A., Menna, G., Rizzari, C., Timeus, F., Micalizzi, C., Lo Nigro, L., Santoro, N., Masetti, R., Micheletti, M. V., Ziino, O., Onofrillo, D., Ladogana, S., Putti, C., Pierani, P., Arena, V., Zecca, M., Foa, R., Locatelli, Franco, Locatelli F. (ORCID:0000-0002-7976-3654), Testi, A. M., Mohamed, S., Diverio, D., Piciocchi, A., Menna, G., Rizzari, C., Timeus, F., Micalizzi, C., Lo Nigro, L., Santoro, N., Masetti, R., Micheletti, M. V., Ziino, O., Onofrillo, D., Ladogana, S., Putti, C., Pierani, P., Arena, V., Zecca, M., Foa, R., Locatelli, Franco, and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

no abstract

Published
2021

3. Clinical features and follow-up in patients with 22q11.2 deletion syndrome

Author

Cancrini, C, Puliafito, P, Digilio, M, Soresina, A, Martino, S, Rondelli, R, Consolini, R, Ruga, E, Cardinale, F, Finocchi, A, Romiti, Ml, Martire, B, Bacchetta, R, Albano, V, Carotti, A, Specchia, F, Montin, D, Cirillo, E, Cocchi, G, Trizzino, A, Bossi, G, Milanesi, O, Azzari, C, Corsello, G, Pignata, C, Aiuti, A, Pietrogrande, M, Marino, B, Ugazio, A, Plebani, A, Rossi, P, Pierani, P, Gabrielli, A, Danieli, M, De Mattia, D, Sisto, C, Dammacco, F, Ranieri, G, Pession, A, Ricci, G, Minelli, P, Lougaris, V, Badolato, R, Cattaneo, R, Airò, P, Mura, R, Cossu, F, Del Giacco, S, Manconi, P, Consarino, C, Dello Russo, A, Miniero, R, Anastasio, E, Marino, S, Russo, G, Paganelli, R, Sperlì, D, Carpino, L, Aricò, M, Gambineri, E, Lippi, F, Canessa, C, Maggi, E, Romagnani, S, Matucci, A, Vultaggio, A, Gattorno, M, Castagnola, E, Nigro, G, Presta, G, Civino, A, Buzi, F, Gambaretto, G, Fasoli, S, Salpietro, C, Gallizzi, R, Dellepiane, R, Panisi, C, Fabio, G, Carrabba, M, Roncarolo, M, Biondi, A, Vallinoto, C, Poggi, V, Menna, G, Di Nardo, R, Sottile, R, Marone, G, Spadaro, G, Carli, M, Basso, G, Putti, C, Semenzato, G, Agostini, C, D'Angelo, P, Izzi, G, Bertolini, P, Zecca, M, Marseglia, G, Maccario, R, Felici, L, Favre, C, Vecchi, V, Sacchini, P, Rinaldi, G, Livadiotti, S, Simonetti, A, Stabile, A, Duse, M, Iacobini, M, Quinti, I, Fiorilli, M, Moschese, V, Cecere, F, D'Ambrosio, A, De Zan, G, Strafella, S, Tamaro, P, Rabusin, M, Tommasini, A, Tovo, P, De Carli, M, De Carli, S, Nespoli, L, Marinoni, M, Porcellini, A, Lunardi, C, Patuzzo, G, Boner, A, Degani, D, Cancrini, C, Puliafito, P, Digilio, Mc, Soresina, A, Martino, S, Rondelli, R, Consolini, R, Ruga, Em, Cardinale, F, Finocchi, A, Romiti, Ml, Martire, B, Bacchetta, R, Albano, V, Carotti, A, Specchia, F, Montin, D, Cirillo, E, Cocchi, G, Trizzino, A, Bossi, G, Milanesi, O, Azzari, C, Corsello, G, Pignata, C, Aiuti, Alessandro, Pietrogrande, Mc, Marino, B, Ugazio, Ag, Plebani, A, Rossi, P., Cancrini, Caterina, Puliafito, Pamela, Digilio, Maria Cristina, Soresina, Annarosa, Martino, Silvana, Rondelli, Roberto, Consolini, Rita, Ruga, Ezia Maria, Cardinale, Fabio, Finocchi, Andrea, Romiti, Maria Luisa, Martire, Baldassarre, Bacchetta, Rosa, Albano, Veronica, Carotti, Adriano, Specchia, Fernando, Montin, Davide, Cirillo, Emilia, Cocchi, Guido, Trizzino, Antonino, Bossi, Grazia, Milanesi, Ornella, Azzari, Chiara, Corsello, Giovanni, Pignata, Claudio, Pietrogrande, Maria Cristina, Marino, Bruno, Ugazio, Alberto Giovanni, Plebani, Alessandro, Rossi, Paolo, Aiuti, A, Rossi, P, Pierani, P, Gabrielli, A, Danieli, Mg, De Mattia, D, Sisto, C, Dammacco, F, Ranieri, G, Pession, A, Ricci, G, Minelli, P, Lougaris, V, Badolato, R, Cattaneo, R, Airò, P, Mura, Rm, Cossu, F, Del Giacco, S, Manconi, Pe, Consarino, C, Dello Russo, Am, Miniero, R, Anastasio, E, Marino, S, Russo, G, Paganelli, R, Sperlì, D, Carpino, L, Aricò, M, Gambineri, E, Lippi, F, Canessa, C, Maggi, E, Romagnani, S, Matucci, A, Vultaggio, A, Gattorno, M, Castagnola, E, Nigro, G, Presta, G, Civino, A, Buzi, F, Gambaretto, G, Fasoli, S, Salpietro, C, Gallizzi, R, Dellepiane, Rm, Panisi, C, Fabio, G, Carrabba, M, Pietrogrande, M, Roncarolo, Mg, Biondi, A, Vallinoto, C, Poggi, V, Menna, G, Di Nardo, R, Sottile, R, Marone, G, Spadaro, G, Carli, M, Basso, G, Putti, C, Semenzato, G, Agostini, C, D'Angelo, P, Izzi, G, Bertolini, P, Zecca, M, Marseglia, G, Maccario, R, Felici, L, Favre, C, Vecchi, V, Sacchini, P, Rinaldi, G, Livadiotti, S, Simonetti, A, Stabile, A, Duse, M, Iacobini, M, Quinti, I, Fiorilli, M, Moschese, V, Cecere, F, D'Ambrosio, A, De Zan, G, Strafella, S, Tamaro, Paolo, Rabusin, M, Tommasini, A, Tovo, P, De Carli, M, De Carli, S, Nespoli, L, Marinoni, M, Porcellini, A, Lunardi, C, Patuzzo, G, Boner, A, Degani, D., Cancrini, C., Pulisfito, P., Digilio, M. C., Soresina, A., Martino, S., Rondelli, R., Consolini, R., Ruga, E. M., C. a. r. d. i. n. a. l. e., F., Finocchi, A., Romiti, M. L., Martire, B., Bacchetta, R., Albano, V., Carotti, A., Specchia, F., Montin, D., Cocchi, G., Trizzino, A., Bossi, G., Milanesi, O., Azzari, C., Corsello, G., Aiuti, A., Pietrogrande, M. C., Marino, B., Ugazio, A. G., Plebani, A., Digilio, MC, Ruga, EM, Romiti, ML, trizzino, A, Aiuti, Pietrogrande, MC, and Ugazio, AG

Subjects
Male, Pediatrics, 22q11.2 deletion, Delayed Diagnosis, Time Factors, Chromosomes, Human, Pair 22, Developmental Disabilities, digeorge syndrome, Sex Factor, Severity of Illness Index, Retrospective Studie, DiGeorge syndrome, Early Diagnosi, Age Factor, Prospective Studies, Neonatal hypocalcemia, Prospective cohort study, Child, medicine.diagnostic_test, Delayed Diagnosi, Primary immune disorders, Age Factors, del 22q, MIM, Abnormalities, Multiple, Adolescent, Adult, Child, Preschool, DiGeorge Syndrome, Early Diagnosis, Female, Follow-Up Studies, Genetic Testing, Humans, Infant, Infant, Newborn, Monitoring, Physiologic, Retrospective Studies, Risk Assessment, Sex Factors, Young Adult, Disease Progression, Cohort, Abnormalities, Multiple, Pediatrics, Perinatology and Child Health, Human, medicine.medical_specialty, Time Factor, Monitoring, Developmental Disabilitie, Italian Association of Pediatric Haematology and Oncology, Context (language use), Chromosomes, Follow-Up Studie, Severity of illness, medicine, 22q11DS, 22q11.2 deletion syndrome, AIEOP, Mendelian Inheritance in Man, Preschool, Physiologic, Genetic testing, Settore MED/38 - Pediatria Generale e Specialistica, business.industry, Retrospective cohort study, medicine.disease, Newborn, Prospective Studie, Pair 22, business
Abstract

Objective To investigate the clinical manifestations at diagnosis and during follow-up in patients with 22q11.2 deletion syndrome to better define the natural history of the disease. Study design A retrospective and prospective multicenter study was conducted with 228 patients in the context of the Italian Network for Primary Immunodeficiencies. Clinical diagnosis was confirmed by cytogenetic or molecular analysis. Results The cohort consisted of 112 males and 116 females; median age at diagnosis was 4 months (range 0 to 36 years 10 months). The diagnosis was made before 2 years of age in 71% of patients, predominantly related to the presence of heart anomalies and neonatal hypocalcemia. In patients diagnosed after 2 years of age, clinical features such as speech and language impairment, developmental delay, minor cardiac defects, recurrent infections, and facial features were the main elements leading to diagnosis. During follow-up (available for 172 patients), the frequency of autoimmune manifestations ( P = .015) and speech disorders ( P = .002) increased. After a median follow-up of 43 months, the survival probability was 0.92 at 15 years from diagnosis. Conclusions Our data show a delay in the diagnosis of 22q11.2 deletion syndrome with noncardiac symptoms. This study provides guidelines for pediatricians and specialists for early identification of cases that can be confirmed by genetic testing, which would permit the provision of appropriate clinical management.

Published
2014

4. The Quality of Life of Children and Adolescents with X-Linked Agammaglobulinemia

Author

Soresina A., Nacinovich R., Bomba M., Cassani M., Molinaro A., Sciotto A., Martino S., Cardinale F., De Mattia D., Putti C., Dellepiane R.M., Felici L., Parrinello G., Neri F., Plebani A., Pierani P., DeMattia D., Martire B., Armenio L., Dammacco F., Ranieri G., Masi M., Miniaci A., Pession A., Rondelli R., Notarangelo L. D., Cao, Cossu F., Del Giacco S., Manconi P., Evangelista I., Magro S., Morgione S., STRISCIUGLIO, PIETRO, Anastasio E., Schillirò G., Paganelli R., Sticca M., Sperlì D., Carpino L., Bernini G., Azzari C., Maggi E., Romagnani S., Matucci A., Vultaggio A., Castagnola E., Gattorno M., Presta G., Civino A., Gambaretto G., Fasoli S., Salpietro C., Pietrogrande M.C., DellePiane R.M., Panisi C., Cambiaghi G., Pietrogrande M., Roncarolo M.G., Aiuti A., Masera G., Biondi A., Sala A., PIGNATA, CLAUDIO, Poggi V., Menna G., Di Nardo R., D'Apuzzo A., Pelliccia A., Correra A., Marone G., SPADARO, GIUSEPPE, Carli M., Zanesco L., Basso G., Putti M.C., Semenzato G., Agostini C., Amato G.M., Aricò M., Trizzino A., Izzi G., Bertolini P., Locatelli F., Zecca M., Rondini G., Marseglia G.L., Maccario R., Bossi G., Favre C., Consolini R., Vecchi V., Sacchini P., Rinaldi G., Ugazio A.G., Rossi P., Livadiotti S., Cancrini C., Finocchi A., Stabile A., Duse M., Iacobini M., Quinti I., Moschese V., Cecere F., Morgese G., Acquaviva A., De Zan G., Strafella S., Tamaro P., Rabusin M., Tovo P.A., Nespoli L., Marinoni M., Porcellini A., Cazzola G.A., Annarosa, Soresina, Renata, Nacinovich, Monica, Bomba, Morena, Cassani, Molinaro, Anna, Antonella, Sciotto, Silvana, Martino, Fabio, Cardinale, Domenico, Mattia, Caterina, Putti, Rosa Maria, Dellepiane, Leonardo, Felici, Giovanni, Parrinello, Francesca, Neri, Alessandro, Plebani, Soresina, A, Nacinovich, R, Bomba, M, Cassani, M, Molinaro, A, Sciotto, A, Martino, S, Cardinale, F, De Mattia, D, Putti, C, Dellepiane, R, Felici, L, Parrinello, G, Neri, F, Plebani, A, Soresina, A., Nacinovich, R., Bomba, M., Cassani, M., Molinaro, A., Sciotto, A., Martino, S., Cardinale, F., De Mattia, D., Putti, C., Dellepiane, R. M., Felici, L., Parrinello, G., Neri, F., Plebani, A., Pierani, P., Demattia, D., Martire, B., Armenio, L., Dammacco, F., Ranieri, G., Masi, M., Miniaci, A., Pession, A., Rondelli, R., Notarangelo, L. D., Cao, Cossu, F., Del Giacco, S., Manconi, P., Evangelista, I., Magro, S., Morgione, S., Strisciuglio, Pietro, Anastasio, E., Schillirò, G., Paganelli, R., Sticca, M., Sperlì, D., Carpino, L., Bernini, G., Azzari, C., Maggi, E., Romagnani, S., Matucci, A., Vultaggio, A., Castagnola, E., Gattorno, M., Presta, G., Civino, A., Gambaretto, G., Fasoli, S., Salpietro, C., Pietrogrande, M. C., Panisi, C., Cambiaghi, G., Pietrogrande, M., Roncarolo, M. G., Aiuti, A., Masera, G., Biondi, A., Sala, A., Pignata, Claudio, Poggi, V., Menna, G., Di Nardo, R., D'Apuzzo, A., Pelliccia, A., Correra, A., Marone, G., Spadaro, Giuseppe, Carli, M., Zanesco, L., Basso, G., Putti, M. C., Semenzato, G., Agostini, C., Amato, G. M., Aricò, M., Trizzino, A., Izzi, G., Bertolini, P., Locatelli, F., Zecca, M., Rondini, G., Marseglia, G. L., Maccario, R., Bossi, G., Favre, C., Consolini, R., Vecchi, V., Sacchini, P., Rinaldi, G., Ugazio, A. G., Rossi, P., Livadiotti, S., Cancrini, C., Finocchi, A., Stabile, A., Duse, M., Iacobini, M., Quinti, I., Moschese, V., Cecere, F., Morgese, G., Acquaviva, A., De Zan, G., Strafella, S., Tamaro, P., Rabusin, M., Tovo, P. A., Nespoli, L., Marinoni, M., Porcellini, A., and Cazzola, G. A.

Subjects
Male, Pediatrics, medicine.medical_specialty, x-linked agammaglobulinemia, Activities of daily living, Adolescent, X-linked agammaglobulinemia, Health Status, Immunology, pedsql 4.0 generic core scale, Quality of life, children, Agammaglobulinemia, Surveys and Questionnaires, Activities of Daily Living, health-related quality of life, parents, medicine, Humans, Immunology and Allergy, PedsQL 4.0 Generic Core Scale, Child, Settore MED/38 - Pediatria Generale e Specialistica, Health related quality of life, quality of live, business.industry, Immunoglobulins, Intravenous, Genetic Diseases, X-Linked, medicine.disease, Socioeconomic Factors, Child, Preschool, Mutation, Quality of Life, Female, X-linked agammaglobulinemia - children - parents - health-related quality of life - PedsQL 4.0 Generic Core Scale, business
Abstract

Introduction: The health-related quality of life in X-linked agammaglobulinemia was investigated in 25 children and adolescents patients through the Italian version of Pediatric Quality of Life Inventory 4.0 Generic Core Scale for patients aged less then 18 years, comparing child perception to that of the parents and the physician's evaluation. The data were compared with the ones of 80 healthy controls and the literature data of a group of patients with rheumatic diseases. Discussion: The agammaglobulinemia subjects perceived a lower global quality of life than the healthy subjects, but significantly higher than the rheumatic diseases controls. The clinical relevance of health-related quality of life assessment in X-linked agammaglobulinemia pediatric patients is discussed. © 2008 Springer Science+Business Media, LLC.

Published
2009

6. Risultati definitivi dello studio prospettico multicentrico di sorveglianza degli effetti collaterali nell'utilizzo delle immunoglobuline per via endovenosa

Author

Soresina A., Rondelli R., Quinti I., Agostini C., Spadaro G., Marzollo R., Martino S., Pietrogrande M.C., Putti C., Trizzino N., Moschese V., Consolini R., Ugazio A.G., Plebani A., PESSION, ANDREA, Soresina A., Rondelli R., Quinti I., Agostini C., Spadaro G., Marzollo R., Martino S., Pietrogrande MC., Putti C., Trizzino N., Moschese V., Consolini R., Pession A., Ugazio AG., and Plebani A.

Published
2007

7. Protocollo AIEOP LAM 2002/01 : risultati preliminari

Author

MASETTI, RICCARDO, Rondelli R., Putti C., Rizzari C., Locatelli F., Santoro N., Luciani M., Menna G., Fagioli F., Lo Nigro L., Micalizzi C., Di Tullio M.T., Basso G., Frascella E., Biondi A., Testi A.M., Zecca M., PESSION, ANDREA, Masetti R., Rondelli R., Putti C., Rizzari C., Locatelli F., Santoro N., Luciani M., Menna G., Fagioli F., Lo Nigro L., Micalizzi C., Di Tullio MT., Basso G., Frascella E., Biondi A., Testi AM., Zecca M., and Pession A.

Published
2007

8. Analisi dei casi di LAM con riarrangiamento della banda 11Q23/gene MLL trattati con il protocollo AIEOP LAM 2002-01:presentazione clinica e risposta al trattamento

Author

Lo Nigro L., Leszl A., Basso G., Putti C., Rizzari C., Locatelli F., Santoro N., Luciani M., Menna G., Fagioli F., Micalizzi C., Di Tullio M.T., Frascella E., Biondi A., Testi A.M., Zecca M., PESSION, ANDREA, Lo Nigro L., Leszl A., Basso G., Putti C., Rizzari C., Locatelli F., Santoro N., Luciani M., Menna G., Fagioli F., Micalizzi C., Di Tullio MT., Frascella E., Biondi A., Testi AM., Zecca M., and Pession A.

Published
2007

9. Expressions and functionality of B lymphocytes in patients with an initial diagnosis of transitory hypogammaglobulinemia of infancy

Author

Moschese, V., La Rocca, M., Graziani, S., Avanzini, M. A., Carsetti, R., Marconi, M., Di Cesare, S., Chini, L., Soresina, A. R., Bossi, G., Trizzino, A., Consolini, R., Cardinale, F., Martino, S., Pignata, C., Zecca, M., Putti, C., PAOLO ROSSI, Plebani, A., Moschese, V., La Rocca, M., Graziani, S., Avanzini, M. A., Carsetti, R., Marconi, M., Di Cesare, S., Chini, L., Soresina, A. R., Bossi, G., Trizzino, A., Consolini, R., Cardinale, F., Martino, S., Pignata, Claudio, Zecca, M., Putti, C., Rossi, P., and Plebani, A.

Subjects
Settore MED/38 - Pediatria Generale e Specialistica
Published
2007

10. Immunoglobulin therapy by intravenous: prospective multicenter surveillance of side effects

Author

Soresina, A., Rondelli, R., Quinti, I., Marzollo, R., Agostini, C., Spadaro, G., Martino, S., Pietrogrande, M. C., Putti, C., Maurizio Arico', Moschese, V., Consolini, R., Plebani, A., Pession, A., Ugazio, A. G., A., Soresina, R., Rondelli, I., Quinti, R., Marzollo, C., Agostini, Spadaro, Giuseppe, S., Martino, M. C., Pietrogrande, C., Putti, M., Arico, V., Moschese, R., Consolini, A., Plebani, A., Pession, and A. G., Ugazio

Subjects
Settore MED/38 - Pediatria Generale e Specialistica
Published
2008

15. Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency

Author

Quinti, I, Soresina, A, Spadaro, G, Martino, S, Donnanno, S, Agostini, C, Claudio, P, Franco, D, Pesce, A, Borghese, F, Guerra, A, Rondelli, R, Plebani, A, De Mattia, D, Martire, B, Cossu, F, Schirillo, G, Castagnola, E, Pietrogrande, M, Delle Piane, R, Putti, C, Trizzino, A, Amato, G, Bertolini, P, Zecca, M, Consolini, R, Moschese, V, Rossi, P, Cancrini, C, Cazzola, G, Quinti, I, Soresina, A, Spadaro, Giuseppe, Martino, S, Donnanno, S, Agostini, C, Claudio, P, Franco, D, MARIA PESCE, A, Borghese, F, Guerra, A, Rondelli, R, Plebani, A, ITALIAN PRIMARY IMMUNODEFICIENCY, Network, SORESINA A., SPADARO G, Pignata, Claudio, and Plebani, A.

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, clinical features, Time Factors, Adolescent, common variable immunodeficiency, Immunology, Immunoglobulins, intravenous immunoglobulins, chronic lung disease, Autoimmune Diseases, Cohort Studies, Age Distribution, Neoplasms, medicine, Immunology and Allergy, Humans, pneumonia, Sinusitis, Prospective cohort study, Child, Preschool, mortality, Aged, Settore MED/38 - Pediatria Generale e Specialistica, Respiratory tract infections, business.industry, Common variable immunodeficiency, Chronic sinusitis, Middle Aged, medicine.disease, Surgery, Survival Rate, Pneumonia, Treatment Outcome, Child, Preschool, Common Variable Immunodeficiency, Female, Follow-Up Studies, Immunotherapy, Cohort, business, Cohort study
Abstract

Common Variable Immunodeficiency belongs to the group of rare diseases encompassing antibody deficiency syndromes of highly variable clinical presentation and outcome. The multicenter prospective study on a cohort of 224 patients with Common Variable Immunodeficiency provides an updated view of the spectrum of illnesses which occurred at the clinical onset and over a long period of follow-up (mean time: 11 years) and information on the effects of long-term immunoglobulin treatment. The mean age at the time of diagnosis was 26.6 years. Seventy-five patients were younger than 14 years of age. The mean age at the onset of symptoms was 16.9 years. This implicates with a mean diagnostic delay of 8.9 years. Respiratory tract infections were the most prominent clinical problem observed at diagnosis and during the follow-up. Intravenous immunoglobulin administration induced a significant reduction in the incidence of acute infections, mainly acute pneumonia and acute otitis. However, a progressive increase in the prevalence of patients with chronic diseases, mainly sinusitis and lung disease, was observed in all age groups, including the pediatric population. The morbidity of Common Variable Immunodeficiency due to all associated clinical conditions increased over time despite an adequate replacement with intravenous immunoglobulins. Our data stressed the need to develop international guidelines for the prevention and therapy of chronic lung disease, chronic sinusitis, chronic diarrhoea, and chronic granulomatosis in patients with humoral immunodeficiencies.

Published
2007

18. Protocollo AIEOP LAM 2002/01: risultati preliminari

Author

Pession, A, Masetti, R, Putti, C, Rizzari, C, Locatelli, F, Santoro, N, Luciani, M, Menna, G, Fagioli, F, Lo Nigro, L, Micalizzi, C, Casale, F, Testi, Anna Maria, Zecca, M, Rondelli, R, Biondi, A, and Basso, G.

Published
2005

20. The quality of life of children and adolescents with X-linked agammaglobulinemia

Author

Soresina, A, Nacinovich, R, Bomba, M, Cassani, M, Molinaro, A, Sciotto, A, Martino, S, Cardinale, F, De Mattia, D, Putti, C, Dellepiane, R, Felici, L, Parrinello, G, Neri, F, Plebani, A, Plebani, A., NACINOVICH, RENATA, NERI, FRANCESCA, Soresina, A, Nacinovich, R, Bomba, M, Cassani, M, Molinaro, A, Sciotto, A, Martino, S, Cardinale, F, De Mattia, D, Putti, C, Dellepiane, R, Felici, L, Parrinello, G, Neri, F, Plebani, A, Plebani, A., NACINOVICH, RENATA, and NERI, FRANCESCA

Abstract

Introduction: The health-related quality of life in X-linked agammaglobulinemia was investigated in 25 children and adolescents patients through the Italian version of Pediatric Quality of Life Inventory 4.0 Generic Core Scale for patients aged less then 18 years, comparing child perception to that of the parents and the physician's evaluation. The data were compared with the ones of 80 healthy controls and the literature data of a group of patients with rheumatic diseases. Discussion: The agammaglobulinemia subjects perceived a lower global quality of life than the healthy subjects, but significantly higher than the rheumatic diseases controls. The clinical relevance of health-related quality of life assessment in X-linked agammaglobulinemia pediatric patients is discussed. © 2008 Springer Science+Business Media, LLC.

Published
2009

23. [Radiosurgical combination for the treatment of soft tissue sarcoma of the extremities]

Author

Frezza G, Ammendolia I, Barbieri E, Corsa P, Neri S, Putti C, Antonio Veraldi, and Babini L

Subjects
Adult, Aged, 80 and over, Postoperative Care, Leg, Adolescent, Radiotherapy, Sarcoma, Soft Tissue Neoplasms, Middle Aged, Combined Modality Therapy, Survival Rate, Preoperative Care, Arm, Humans, Aged, Follow-Up Studies
Abstract

From January 1979 to December 1987, 99 patients with a diagnosis of localized soft-tissue sarcoma of the extremities received preoperative radiation therapy (50 patients) or postoperative irradiation (49 cases). In the preoperative RT group, doses ranged from 42 Gy/14 fractions to 51 Gy/17 fractions; the patients treated with postoperative radiation therapy received 46 Gy/23 fractions. The surgical procedure was in each patient complete resection of the mass with preservation of the affected limb. The main cause of failure were distant metastases (33.3%). The incidence of local recurrences was low (7.1%). Recurrences were related to tumor size [less than 5 cm: 0/12; 5-10 cm: 2/45 (2.3%; greater than 10 cm: 5/42 (11.9%)]. The incidence of distant metastases was higher in the group treated with preoperative radiation therapy (44% versus 22.4%), probably because a higher percentage of patients in this group had large tumors. Late complications were analyzed in 59 patients with a follow-up longer than 24 months. Severe complications rate was low (6/59 cases, 10.1%), and higher in the preoperative than in the postoperative RT group (15.4% versus 6.1%), which is probably related to the different fractionations administered.

Published
1991

25. 706Long term follow-up of localized Ewing's sarcoma

Author

Barbieri, E., primary, Putti, C., additional, Ammendolia, I., additional, Baldissera, A., additional, Chiaulon, G., additional, Mancini, A., additional, Palmieri, T., additional, Frezza, G., additional, Mercuri, M., additional, and Babini, L., additional

Published
1996
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27. Co‐expression of myeloid antigens in childhood acute lymphoblastic leukaemia: relationship with the stage of differentiation and clinical significance

Author

Cantù‐Rajnoldi, A., primary, Putti, C., additional, Saitta, M., additional, Granchi, D., additional, Foà, R., additional, Schirò, R., additional, Castagni, M., additional, Valeggio, C., additional, Jankovic, M., additional, Miniero, R., additional, Paolucci, P., additional, and Basso, G., additional

Published
1991
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30. Combined treatment in Ewing's sarcoma

Author

Bacci, G, Bertoni, F, Borghi, A, Calderoni, P, Capanna, Rodolfo, Cervellati, C, Gherlinzoni, F, Giunti, A, Guerra, A, Guernelli, N, Mercuri, M, Picci, P, Putti, C, and Campanacci, M.

Published
1983

33. A prospective study on 136 patients with agammaglobulinemia X-recessive: results from the italian primary immunodeficiencies network

Author

Soresina, S. A., Rondelli, R., Quinti, I., Azzari, C., Pietro-Grande, M. C., Martino, S., Mattia, D., Martire, M. B., PAOLO ROSSI, Cardinale, C. F., Moschese, V., Masi, M. M., Pignata, P. C., Cazzola, C. G., Consolini, R., Duse, D. M., Stabile, S. A., Locatelli, F., Sciotto, S. A., Di Nardo, D. N. R., Anastasio, A. E., Marseglia, M. G. L., Nespoli, N. L., Putti, C., Trizzino, T. A., Gattorno, G. M., Felici, F. L., Fiorini, F. M., Pession, A., Ugazio, A. G., and Plebani, A.

Subjects
Settore MED/38 - Pediatria Generale e Specialistica

34. Outcome of relapsed/refractory acute promyelocytic leukaemia in children, adolescents and young adult patients — a 25-year Italian experience

Author

Concetta Micalizzi, Luca Lo Nigro, Alfonso Piciocchi, Giuseppe Menna, Nicola Santoro, C. Putti, Anna Maria Testi, Saverio Ladogana, Robin Foà, Riccardo Masetti, Marco Zecca, Paolo Pierani, Ottavio Ziino, Valentina Arena, Daniela Onofrillo, Franco Locatelli, Carmelo Rizzari, Maria Vittoria Micheletti, Fabio Timeus, Daniela Diverio, Sara Mohamed, Testi, A, Mohamed, S, Diverio, D, Piciocchi, A, Menna, G, Rizzari, C, Timeus, F, Micalizzi, C, Lo Nigro, L, Santoro, N, Masetti, R, Micheletti, M, Ziino, O, Onofrillo, D, Ladogana, S, Putti, C, Pierani, P, Arena, V, Zecca, M, Foa, R, Locatelli, F, Testi A.M., Mohamed S., Diverio D., Piciocchi A., Menna G., Rizzari C., Timeus F., Micalizzi C., Lo Nigro L., Santoro N., Masetti R., Micheletti M.V., Ziino O., Onofrillo D., Ladogana S., Putti C., Pierani P., Arena V., Zecca M., Foa R., and Locatelli F.

Subjects
Male, Pediatrics, medicine.medical_specialty, Adolescent, acute promyelocytic leukaemia, Salvage treatment, salvage treatment, Antineoplastic Agents, Tretinoin, Young Adult, Antineoplastic Agents, Immunological, Arsenic Trioxide, Leukemia, Promyelocytic, Acute, immune system diseases, medicine, Humans, Anthracyclines, Young adult, Child, neoplasms, Retrospective Studies, Salvage Therapy, business.industry, Remission Induction, Hematopoietic Stem Cell Transplantation, Hematology, Prognosis, Combined Modality Therapy, Gemtuzumab, Progression-Free Survival, Treatment Outcome, Italy, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, adolescent children, Case-Control Studies, Child, Preschool, Relapsed refractory, relapsed/refractory disease, Early adolescents, Female, Acute promyelocytic leukaemia, Neoplasm Recurrence, Local, business
Abstract

Acute promyelocytic leukaemia (APL) is a rare subtype ofchildhood acute myeloid leukaemia (AML), accounting for5–12% of all AML cases. Treatment with all-trans-retinoicacid (ATRA) and anthracyclines yields complete remission(CR) rates >90% and 10-year event-free survival (EFS) ratesaround 80%.1–3The recent front-line arsenic trioxide(ATO)-based regimens have further improved the APL out-come by reducing toxicity and preventing relapse.4–6Relapsed APL patients are a rare and heterogeneous group,whose prognosis depends on front-line treatment and timeelapsing between diagnosis and recurrence. Currently, ATOis the treatment of choice for relapsed APL. Due to the rarityof relapsed childhood APL, 17–27% in ATRA- andchemotherapy-1,3,7–9and 4% in ATO-containing regimens,10it will be difficult, in the future, to design future prospectivecomparative trials for these patients. In an attempt to designtherapeutic guidelines, recommendations on management ofrelapsed/refractory paediatric APL have been publishedrecently

Published
2021

36. Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy-An observational Ponte di Legno Toxicity Working Group Study.

Author

Anastasopoulou S, Swann G, Andres-Jensen L, Attarbaschi A, Barzilai-Birenboim S, Erdelyi DJ, Escherich G, Hamadeh L, Harila A, Lopez-Lopez E, McGowan S, Möricke A, Putti C, Sagi JC, Schmiegelow K, Ullrich NJ, van der Sluis IM, Wahid QU, Winick N, Sramkova L, Zalcberg Y, Zapotocka E, Bhojwani D, and Halsey C

Subjects
Humans, Child, Male, Female, Adolescent, Child, Preschool, Neurotoxicity Syndromes etiology, Steroids therapeutic use, Steroids adverse effects, Dexamethasone adverse effects, Dexamethasone therapeutic use, Dexamethasone administration & dosage, Infant, Antineoplastic Combined Chemotherapy Protocols adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Abstract

Steroids are a mainstay in the treatment of acute lymphoblastic leukaemia (ALL) in children and adolescents; however, their use can cause clinically significant steroid-related neuropsychiatric symptoms (SRNS). As current knowledge on SRNS during ALL treatment is limited, we mapped the phenotypes, occurrence and treatment strategies using a database created by the international Ponte di Legno Neurotoxicity Working Group including data on toxicity in the central nervous system (CNS) in patients treated with frontline ALL protocols between 2000 and 2017. Ninety-four of 1813 patients in the CNS toxicity database (5.2%) experienced clinically significant SRNS with two peaks: one during induction and one during intensification phase. Dexamethasone was implicated in 86% of SRNS episodes. The most common symptoms were psychosis (52%), agitation (44%) and aggression (31%). Pharmacological treatment, mainly antipsychotics and benzodiazepines, was given to 87% of patients while 38% were hospitalised due to their symptoms. Recurrence of symptoms was reported in 29% of patients and two previously healthy patients required ongoing pharmacological treatment at the last follow up. Awareness of SRNS during ALL treatment and recommendation on treatment strategies merit further studies and consensus., (© 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.)

Published
2024
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37. Outcome of relapsed/refractory acute promyelocytic leukaemia in children, adolescents and young adult patients - a 25-year Italian experience.

Author

Testi AM, Mohamed S, Diverio D, Piciocchi A, Menna G, Rizzari C, Timeus F, Micalizzi C, Lo Nigro L, Santoro N, Masetti R, Micheletti MV, Ziino O, Onofrillo D, Ladogana S, Putti C, Pierani P, Arena V, Zecca M, Foà R, and Locatelli F

Subjects
Adolescent, Anthracyclines administration & dosage, Anthracyclines therapeutic use, Antineoplastic Agents administration & dosage, Antineoplastic Agents therapeutic use, Antineoplastic Agents, Immunological administration & dosage, Antineoplastic Agents, Immunological therapeutic use, Arsenic Trioxide administration & dosage, Case-Control Studies, Child, Child, Preschool, Combined Modality Therapy, Female, Gemtuzumab administration & dosage, Hematopoietic Stem Cell Transplantation methods, Humans, Italy epidemiology, Leukemia, Promyelocytic, Acute diagnosis, Leukemia, Promyelocytic, Acute epidemiology, Leukemia, Promyelocytic, Acute mortality, Male, Prognosis, Progression-Free Survival, Remission Induction, Retrospective Studies, Salvage Therapy methods, Salvage Therapy statistics & numerical data, Treatment Outcome, Tretinoin administration & dosage, Tretinoin therapeutic use, Young Adult, Arsenic Trioxide therapeutic use, Gemtuzumab therapeutic use, Leukemia, Promyelocytic, Acute drug therapy, Neoplasm Recurrence, Local prevention & control
Published
2021
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38. Chondrodysplasia and growth failure in children after early hematopoietic stem cell transplantation for non-oncologic disorders.

Author

Botto LD, Meeths M, Campos-Xavier B, Bergamaschi R, Mazzanti L, Scarano E, Finocchi A, Cancrini C, Zirn B, Kühnle I, Kramm CM, Alanay Y, Jones WD, Irving M, Sabir A, Henter JI, Borgström B, Nordgren A, Hammarsjö A, Putti C, Mozzato C, Zuccarello D, Nishimura G, Bonafè L, Grigelioniene G, Unger S, and Superti-Furga A

Subjects
Child, Child, Preschool, Female, Humans, Lymphohistiocytosis, Hemophagocytic complications, Lymphohistiocytosis, Hemophagocytic diagnosis, Lymphohistiocytosis, Hemophagocytic therapy, Male, Membrane Proteins genetics, Osteochondrodysplasias complications, Osteochondrodysplasias diagnosis, Osteochondrodysplasias therapy, Perforin genetics, Treatment Outcome, Hematopoietic Stem Cell Transplantation adverse effects, Lymphohistiocytosis, Hemophagocytic genetics, Osteochondrodysplasias genetics
Abstract

Bone dysplasias (osteochondrodysplasias) are a large group of conditions associated with short stature, skeletal disproportion, and radiographic abnormalities of skeletal elements. Nearly all are genetic in origin. We report a series of seven children with similar findings of chondrodysplasia and growth failure following early hematopoietic stem cell transplantation (HSCT) for pediatric non-oncologic disease: hemophagocytic lymphohistiocytosis or HLH (five children, three with biallelic HLH-associated variants [in PRF1 and UNC13D] and one with HLH secondary to visceral Leishmaniasis), one child with severe combined immunodeficiency and one with Omenn syndrome (both children had biallelic RAG1 pathogenic variants). All children had normal growth and no sign of chondrodysplasia at birth and prior to their primary disease. After HSCT, all children developed growth failure, with standard deviation scores for height at or below -3. Radiographically, all children had changes in the spine, metaphyses and epiphyses, compatible with a spondyloepimetaphyseal dysplasia. Genomic sequencing failed to detect pathogenic variants in genes associated with osteochondrodysplasias. We propose that such chondrodysplasia with growth failure is a novel, rare, but clinically important complication following early HSCT for non-oncologic pediatric diseases. The pathogenesis is unknown but could possibly involve loss or perturbation of the cartilage-bone stem cell population., (© 2020 Wiley Periodicals LLC.)

Published
2021
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39. The quality of life of children and adolescents with X-linked agammaglobulinemia.

Author

Soresina A, Nacinovich R, Bomba M, Cassani M, Molinaro A, Sciotto A, Martino S, Cardinale F, De Mattia D, Putti C, Dellepiane RM, Felici L, Parrinello G, Neri F, and Plebani A

Subjects
Activities of Daily Living, Adolescent, Agammaglobulinemia drug therapy, Agammaglobulinemia genetics, Child, Child, Preschool, Female, Genetic Diseases, X-Linked drug therapy, Genetic Diseases, X-Linked genetics, Health Status, Humans, Immunoglobulins, Intravenous therapeutic use, Male, Mutation genetics, Parents, Socioeconomic Factors, Surveys and Questionnaires, Agammaglobulinemia psychology, Genetic Diseases, X-Linked psychology, Quality of Life
Abstract

Introduction: The health-related quality of life in X-linked agammaglobulinemia was investigated in 25 children and adolescents patients through the Italian version of Pediatric Quality of Life Inventory 4.0 Generic Core Scale for patients aged less then 18 years, comparing child perception to that of the parents and the physician's evaluation. The data were compared with the ones of 80 healthy controls and the literature data of a group of patients with rheumatic diseases., Discussion: The agammaglobulinemia subjects perceived a lower global quality of life than the healthy subjects, but significantly higher than the rheumatic diseases controls. The clinical relevance of health-related quality of life assessment in X-linked agammaglobulinemia pediatric patients is discussed.

Published
2009
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40. Non conventional fractionation in radiotherapy of the musculo-skeletal sarcomas.

Author

Barbieri E, Frezza G, Martelli O, Neri S, Mercuri M, Gherlinzoni F, Bacci G, Mancini A, Putti C, and Babini L

Subjects
Adult, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Chemotherapy, Adjuvant, Female, Humans, Male, Middle Aged, Neoplasms, Muscle Tissue drug therapy, Neoplasms, Muscle Tissue surgery, Radiotherapy, Adjuvant, Remission Induction, Sarcoma, Ewing radiotherapy, Treatment Outcome, Arm, Bone Neoplasms radiotherapy, Dose Fractionation, Radiation, Leg, Neoplasms, Muscle Tissue radiotherapy, Sarcoma radiotherapy
Abstract

In 1989 we started an accelerated hyperfractionated schedule of radiotherapy (two 1.6 Gy daily fractions) in standard risk localized Ewing's sarcoma of bone, with the aim at reducing late effects in young patients and at improving disease control through a better integration of treatment modalities. From 1991, the same schedule was used in preoperative radiotherapy of adult soft tissue sarcomas of the extremities: the main purpose was to reduce the time to surgery and to evaluate surgical complications in comparison with a previous experience of hypofractionated radiotherapy (one 3 Gy daily fraction). From 1991 to 1997, 76 patients with Ewing's sarcoma and 24 patients with soft tissue sarcoma were treated at our Institution. Results and complication rates are analyzed in comparison with historical data. In Ewing's sarcoma, a correct evaluation of improvement in local control was difficult because of changing treatment policy (bulky disease was not included in the present series). Late effects, as evaluated in patients with a minimum follow-up of 3 years, occurred with similar incidence, but at higher total dose levels in patients treated with accelerated hyperfractionation. In patients with soft tissue sarcomas, incidence of surgical complications is reduced as compared to historical experience. Major problems of wound healing were seen in association with intraoperative brachitherapy boost.

Published
1998
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41. Radiotherapy in vertebral tumors. Indications and limits: a report on 28 cases of Ewing's sarcoma of the spine.

Author

Barbieri E, Chiaulon G, Bunkeila F, Putti C, Frezza G, Neri S, Boriani S, Campanacci M, and Babini L

Subjects
Adolescent, Adult, Child, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Laminectomy, Male, Neoplasm Metastasis, Radiotherapy Dosage, Sarcoma, Ewing surgery, Spinal Neoplasms surgery, Time Factors, Cervical Vertebrae, Lumbar Vertebrae, Sacrum, Sarcoma, Ewing radiotherapy, Spinal Neoplasms radiotherapy, Thoracic Vertebrae
Abstract

After brief notes on techniques used to radiate the spine, its indications and the limits of doses required by its adjacency to the spinal cord, our experience in the treatment of 28 patients with a diagnosis of Ewing's sarcoma localized in the spine, not metastatic at onset, that came to our observation between 1980 and 1994 is reported. All of the patients were treated by chemotherapy. As for local treatment radiotherapy was performed in all of the cases, in 50% of cases it was associated with surgery (6 laminectomies, 6 excisions, and 2 vertebrectomies). Five-year survival rate was 43.5%. The prognosis of this group of patients was intermediate among forms localized in the limbs and those localized in the pelvis. There is a greater frequency of cerebral (20%) and skeletal metastases (55%) as compared to the disease that occurred in other sites where secondary pulmonary localizations generally prevailed. Local control was similar for disease occurring in other sites despite the need to deliver doses that were lower than those typically used for this pathology in regions above the cauda.

Published
1998

42. The effect of cytokines, including IL4, IL7, stem cell factor, insulin-like growth factor on childhood acute lymphoblastic leukemia.

Author

Consolini R, Legitimo A, Cattani M, Simi P, Mattii L, Petrini M, Putti C, and Basso G

Subjects
Adolescent, Cell Differentiation drug effects, Cell Division drug effects, Child, Child, Preschool, Humans, Tumor Cells, Cultured, Tumor Stem Cell Assay, Cytokines pharmacology, Insulin-Like Growth Factor I pharmacology, Interleukin-4 pharmacology, Interleukin-7 pharmacology, Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology, Stem Cell Factor pharmacology
Abstract

We have investigated the effects of some interleukins, such as interleukin (IL) 4, IL7, stem cell factor (SCF) and insulin-like growth factor (IGF-1), known to be involved in human lymphopoiesis, on proliferation, clonal growth and differentiation of cells from two acute lymphoblastic leukemia (ALL) derived pre-B cell lines, that is, Nalm 1, Nalm 6 and purified blasts from 37 childhood ALL. IL4 did not display any promoting activity, an inhibitory effect being observed in two patients. IL7 showed an heterogeneous responsiveness, not related to immunophenotype or cytogenetic features, proliferation and clonal growth being observed in a minority of ALL. In other patients no or even inhibitory effects on proliferation were observed. In one case this inhibition of DNA synthesis was accompanied by maturation of the cells, as demonstrated by the induced expression of surface immunoglobulins (slg); other IL7 treated samples failed to express slg, but showed a decreased expression of terminal deoxynucleotidyl transferase and cALL antigen, suggesting that the cells have a potential of limited maturation by IL7. SCF, known to synergize with IL7 in the most primitive stages of normal B cell development, did not enhance the IL7 response in B cell precursor ALL. Finally IGF-1 failed to induce a proliferative response and clonal growth in BCP ALL either alone or in combination with IL7.

Published
1997
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43. Evaluation of minimal residual disease in high risk childhood acute lymphoblastic leukemia using an immunological approach during complete remission. AIEOP Cooperative Group for Immunology of Acute Leukemias.

Author

Consolini R, Scamardella F, Legitimo A, Putti C, Granchi D, Paolucci P, Lippi A, Guazzelli C, Acquaviva A, and Rosanda C

Subjects
Adolescent, Child, Child, Preschool, Follow-Up Studies, Humans, Remission Induction, Risk Factors, Precursor Cell Lymphoblastic Leukemia-Lymphoma immunology
Abstract

Background: Sensitive methods for detecting residual disease may complement conventional morphology while monitoring the response to treatment in leukemia patients., Methods: We studied minimal residual disease (MRD) by selecting via a colony assay a peripheral blood (PB) cell population enriched in putative malignant cells and detecting occult leukemic cells by double immunologic analysis performed on colonyforming cells (CFC). Using this combined technique we assayed the PB of high risk children with acute lymphoblastic leukemia (ALL) in order to demonstrate possible differences in "the residual tumor cell burden" among leukemia patients and to correlate these with a 3-year clinical follow-up., Results: In all 22 patients positive results were obtained for up to 18 months following induction chemotherapy at times of apparent hematologic remission. Common ALL (cALL) patients exhibited a mean of 9.6% cAlla+ cells (range: 2% to 30%), whereas cALL antigen (cALLA) and cALLA/Tdt or CD1a/Tdt combination were never found in the colonies derived from healthy individuals. Six out of 22 cALL patients expressed a mean of 16.5% cALLA+/Tdt+ CFC (range: 2% to 35%). Five T-ALL children presented a mean of 24% CD1a/Tdt+ cells (range: 8% to 44%). Extensive follow-up indicates a correlation between the percentage of CFC Tdt+/lymphoid marker+ cells (more than 10%) and subsequent clinical relapse. In one patient relapse occurred after 16 months with a dramatic increase in the number of leukemic cells. In contrast, the decline in malignant cells, observed in two cases, predicted a favourable course. Five patients tested before autologous bone marrow transplantation (ABMT) presented high number of positive cells and relapsed at various times., Conclusions: We conclude that this approach to the study of MRD could be valuable in monitoring the efficacy of chemotherapy, as well in evaluating the quality of purged marrow.

Published
1993

48. Neoadjuvant chemotherapy for localized Ewing's sarcoma. Preliminary results of a new protocol which uses surgery alone or followed by radiotherapy for local control.

Author

Cagnano R, Avella M, Rosito P, Ciaroni D, Ferraro A, Di Scioscio M, Putti C, and Bacci G

Subjects
Amputation, Surgical, Biopsy, Clinical Trials as Topic, Combined Modality Therapy, Disease-Free Survival, Follow-Up Studies, Humans, Recurrence, Sarcoma, Ewing radiotherapy, Sarcoma, Ewing surgery, Time Factors, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Chemotherapy, Adjuvant, Sarcoma, Ewing drug therapy
Published
1989

49. [Sialography and scintigraphy in salivary pathology (author's transl)].

Author

Putti C, De Florio L, Vallania G, Ghigi G, and Zompatori M

Subjects
Humans, Salivary Gland Diseases diagnostic imaging, Salivary Gland Neoplasms diagnostic imaging, Radionuclide Imaging, Salivary Gland Diseases diagnosis, Salivary Gland Neoplasms diagnosis, Sialography
Abstract

58 cases of salivary glands pathology were investigated by means of sialography and scintigraphy in order to compare these methods. The usefulness of this association is discussed and a number of significant cases are presented.

Published
1976

50. [Neuroblastoma metastatic to the skull. Radiologic aspects and therapeutic problems].

Author

Mancini AF, Rosito P, Capucci MC, Bousi S, Lucchi A, Tani G, Galassi E, Putti C, and Mancuso A

Subjects
Combined Modality Therapy, Humans, Neuroblastoma diagnostic imaging, Neuroblastoma drug therapy, Neuroblastoma radiotherapy, Skull Neoplasms diagnostic imaging, Skull Neoplasms drug therapy, Skull Neoplasms radiotherapy, Tomography, X-Ray Computed, Neuroblastoma secondary, Skull Neoplasms secondary
Abstract

Clinical-radiological findings, treatment and prognosis of cranial involvement in 19 cases of neuroblastoma stage IV have been considered. The most frequent clinical features were periorbital ecchymosis and intracranial hypertension. The radiographic aspects, graduated according to the type of the lesion, showed a close correlation with clinical findings and sometimes preceded them. Computerized tomography, carried out in 12 cases, was more reliable than plain films in identifying the site and extent of cranial lesions and the presence of cerebral extensions, as occurred in 2 patients. The presence of cranial involvement at diagnosis was an unfavorable prognostic sign. The 19 children were treated in various ways so that firm conclusions cannot be drawn, but cranial radiotherapy in combination with chemotherapy appeared to be more efficacious than chemotherapy alone.

Published
1985

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