1. Carboxymethyl chitosan characteristic for drug delivery application and its intermolecular interactions.
- Author
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Siahaan, Parsaoran, Triandani, Ni Wayan Pratiwi, Putra, Risky Ade, Jannah, Cholifatul, Hudiyanti, Dwi, Hildayani, Suci Zulaikha, and Prasasty, Vivitri Dewi
- Subjects
INTERMOLECULAR interactions ,CHITOSAN ,TELEMATICS ,NICOTINAMIDE ,BINDING energy ,DATA release - Abstract
It was found that CMCs had higher water solubility than Cs. The Cs, CMC-B and CMC-C had the water solubility 16.07%, 41.91% and 46.56%, respectively. The conductivity of CMC in water is higher than chitosan. Those two characteristic had improve the ability in carrying active compound of nicotinamide (NAM) represented as encapsulation efficiency (EE). The CMC-B and CMC-C encapsulation efficiency (EE) were 69.71% and 63.95%, respectively, while the Cs only 60.20%. The releasing of NAM from CMC matrix system was easier than Cs. The binding energy of CMC-3...nicotinamide and CMC-15...nicotinamide complexes were -2.56 kcal/mole and -3.49 kcal/mole, respectively. The encapsulation and release kinetics data and processes have the interrelationship with intermolecular interaction energy. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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