Search

Your search keyword '"Putluri, Vasanta"' showing total 328 results
Start Over Author "Putluri, Vasanta"
328 results on '"Putluri, Vasanta"'

1. Metabolomic profiles in Jamaican children with and without autism spectrum disorder

Author

Yazdani, Akram, Samms-Vaughan, Maureen, Saroukhani, Sepideh, Bressler, Jan, Hessabi, Manouchehr, Tahanan, Amirali, Grove, Megan L., Gangnus, Tanja, Putluri, Vasanta, Kamal, Abu Hena Mostafa, Putluri, Nagireddy, Loveland, Katherine A., and Rahbar, Mohammad H.

Subjects
Quantitative Biology - Biomolecules
Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a wide range of behavioral and cognitive impairments. While genetic and environmental factors are known to contribute to its etiology, the underlying metabolic perturbations associated with ASD which can potentially connect genetic and environmental factors, remain poorly understood. Therefore, we conducted a metabolomic case-control study and performed a comprehensive analysis to identify significant alterations in metabolite profiles between children with ASD and typically developing (TD) controls. The objective of this study is to elucidate potential metabolomic signatures associated with ASD in children and identify specific metabolites that may serve as biomarkers for the disorder. We conducted metabolomic profiling on plasma samples from participants in the second phase of Epidemiological Research on Autism in Jamaica, a cohort of 200 children with ASD and 200 TD controls (2-8 years old). Using high-throughput liquid chromatography-mass spectrometry techniques, we performed a targeted metabolite analysis, encompassing amino acids, lipids, carbohydrates, and other key metabolic compounds. After quality control and imputation of missing values, we performed univariable and multivariable analysis using normalized metabolites while adjusting for covariates, age, sex, socioeconomic status, and child's parish of birth. Our findings revealed unique metabolic patterns in children with ASD for four metabolites compared to TD controls. Notably, three of these metabolites were fatty acids, including myristoleic acid, eicosatetraenoic acid, and octadecenoic acid. Additionally, the amino acid sarcosine exhibited a significant association with ASD. These findings highlight the role of metabolites in the etiology of ASD and suggest opportunities for the development of targeted interventions.

Published
2024

2. Vitamin B2 enables regulation of fasting glucose availability.

Author

Masschelin, Peter M, Saha, Pradip, Ochsner, Scott A, Cox, Aaron R, Kim, Kang Ho, Felix, Jessica B, Sharp, Robert, Li, Xin, Tan, Lin, Park, Jun Hyoung, Wang, Liping, Putluri, Vasanta, Lorenzi, Philip L, Nuotio-Antar, Alli M, Sun, Zheng, Kaipparettu, Benny Abraham, Putluri, Nagireddy, Moore, David D, Summers, Scott A, McKenna, Neil J, and Hartig, Sean M

Subjects
Liver, Animals, Mice, Flavin-Adenine Dinucleotide, Glucose, Fatty Acids, Flavoproteins, PPAR alpha, Fasting, Oxidation-Reduction, Non-alcoholic Fatty Liver Disease, FAD, cell biology, gluconeogenesis, inborn errors of metabolism, metabolism, mouse, nuclear receptor, Nutrition, Liver Disease, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Biochemistry and Cell Biology
Abstract

Flavin adenine dinucleotide (FAD) interacts with flavoproteins to mediate oxidation-reduction reactions required for cellular energy demands. Not surprisingly, mutations that alter FAD binding to flavoproteins cause rare inborn errors of metabolism (IEMs) that disrupt liver function and render fasting intolerance, hepatic steatosis, and lipodystrophy. In our study, depleting FAD pools in mice with a vitamin B2-deficient diet (B2D) caused phenotypes associated with organic acidemias and other IEMs, including reduced body weight, hypoglycemia, and fatty liver disease. Integrated discovery approaches revealed B2D tempered fasting activation of target genes for the nuclear receptor PPARα, including those required for gluconeogenesis. We also found PPARα knockdown in the liver recapitulated B2D effects on glucose excursion and fatty liver disease in mice. Finally, treatment with the PPARα agonist fenofibrate activated the integrated stress response and refilled amino acid substrates to rescue fasting glucose availability and overcome B2D phenotypes. These findings identify metabolic responses to FAD availability and nominate strategies for the management of organic acidemias and other rare IEMs.

Published
2023

4. Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state

Author

Yu, Wangie, Chen, Yunyun, Putluri, Nagireddy, Osman, Abdullah, Coarfa, Cristian, Putluri, Vasanta, Kamal, Abu H. M., Asmussen, Jennifer Kay, Katsonis, Panagiotis, Myers, Jeffrey N., Lai, Stephen Y., Lu, Wuhao, Stephan, Clifford C., Powell, Reid T., Johnson, Faye M., Skinner, Heath D., Kazi, Jawad, Ahmed, Kazi Mokim, Hu, Linghao, Threet, Addison, Meyer, Matthew D., Bankson, James A., Wang, Tony, Davis, Jack, Parker, Kirby R., Harris, Madison A., Baek, Mokryun L., Echeverria, Gloria V., Qi, Xiaoli, Wang, Jin, Frederick, Andy I., Walsh, Alex J., Lichtarge, Olivier, Frederick, Mitchell J., and Sandulache, Vlad C.

Published
2023
Full Text
View/download PDF

5. Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood

Author

Treviño, Lindsey S, Dong, Jianrong, Kaushal, Ahkilesh, Katz, Tiffany A, Jangid, Rahul Kumar, Robertson, Matthew J, Grimm, Sandra L, Ambati, Chandra Shekar R, Putluri, Vasanta, Cox, Aaron R, Kim, Kang Ho, May, Thaddeus D, Gallo, Morgan R, Moore, David D, Hartig, Sean M, Foulds, Charles E, Putluri, Nagireddy, Coarfa, Cristian, and Walker, Cheryl Lyn

Subjects
Human Genome, Estrogen, Digestive Diseases, Genetics, Aging, Nutrition, 2.1 Biological and endogenous factors, Aetiology, Animals, DNA Methylation, Early Growth Response Protein 1, Endocrine Disruptors, Epigenesis, Genetic, Epigenome, Epigenomics, Female, Gene-Environment Interaction, Genome-Wide Association Study, Male, Rats
Abstract

Our early-life environment has a profound influence on developing organs that impacts metabolic function and determines disease susceptibility across the life-course. Using a rat model for exposure to an endocrine disrupting chemical (EDC), we show that early-life chemical exposure causes metabolic dysfunction in adulthood and reprograms histone marks in the developing liver to accelerate acquisition of an adult epigenomic signature. This epigenomic reprogramming persists long after the initial exposure, but many reprogrammed genes remain transcriptionally silent with their impact on metabolism not revealed until a later life exposure to a Western-style diet. Diet-dependent metabolic disruption was largely driven by reprogramming of the Early Growth Response 1 (EGR1) transcriptome and production of metabolites in pathways linked to cholesterol, lipid and one-carbon metabolism. These findings demonstrate the importance of epigenome:environment interactions, which early in life accelerate epigenomic aging, and later in adulthood unlock metabolically restricted epigenetic reprogramming to drive metabolic dysfunction.

Published
2020

9. Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer.

Author

Bader, David, Hartig, Sean, Putluri, Vasanta, Foley, Christopher, Hamilton, Mark, Smith, Eric, Saha, Pradip, Panigrahi, Anil, Walker, Christopher, Zong, Lin, Martini-Stoica, Heidi, Chen, Rui, Rajapakshe, Kimal, Coarfa, Cristian, Sreekumar, Arun, Mitsiades, Nicholas, Bankson, James, Ittmann, Michael, OMalley, Bert, Putluri, Nagireddy, and McGuire, Sean

Subjects
Animals, Biological Transport, Cell Line, Tumor, Disease Models, Animal, Gene Expression Regulation, Neoplastic, Glutamine, Humans, Male, Metabolic Networks and Pathways, Mice, Mice, Transgenic, Mitochondria, Mitochondrial Membrane Transport Proteins, Monocarboxylic Acid Transporters, Prostatic Neoplasms, Prostatic Neoplasms, Castration-Resistant, Protein Binding, Pyruvic Acid, Receptors, Androgen, Signal Transduction
Abstract

Specific metabolic underpinnings of androgen receptor (AR)-driven growth in prostate adenocarcinoma (PCa) are largely undefined, hindering the development of strategies to leverage the metabolic dependencies of this disease when hormonal manipulations fail. Here we show that the mitochondrial pyruvate carrier (MPC), a critical metabolic conduit linking cytosolic and mitochondrial metabolism, is transcriptionally regulated by AR. Experimental MPC inhibition restricts proliferation and metabolic outputs of the citric acid cycle (TCA) including lipogenesis and oxidative phosphorylation in AR-driven PCa models. Mechanistically, metabolic disruption resulting from MPC inhibition activates the eIF2α/ATF4 integrated stress response (ISR). ISR signaling prevents cell cycle progression while coordinating salvage efforts, chiefly enhanced glutamine assimilation into the TCA, to regain metabolic homeostasis. We confirm that MPC function is operant in PCa tumors in-vivo using isotopomeric metabolic flux analysis. In turn, we apply a clinically viable small molecule targeting the MPC, MSDC0160, to pre-clinical PCa models and find that MPC inhibition suppresses tumor growth in hormone-responsive and castrate-resistant conditions. Collectively, our findings characterize the MPC as a tractable therapeutic target in AR-driven prostate tumors.

Published
2019

10. Retraction: Tobacco-specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer

Author

Jin, Feng, primary, Thaiparambil, Jose, additional, Donepudi, Sri Ramya, additional, Vantaku, Venkatrao, additional, Piyarathna, Danthasinghe Waduge Badrajee, additional, Maity, Suman, additional, Krishnapuram, Rashmi, additional, Putluri, Vasanta, additional, Gu, Franklin, additional, Purwaha, Preeti, additional, Bhowmik, Salil Kumar, additional, Ambati, Chandrashekar R., additional, von Rundstedt, Friedrich-Carl, additional, Roghmann, Florian, additional, Berg, Sebastian, additional, Noldus, Joachim, additional, Rajapakshe, Kimal, additional, Gödde, Daniel, additional, Roth, Stephan, additional, Störkel, Stephan, additional, Degener, Stephan, additional, Michailidis, George, additional, Kaipparettu, Benny Abraham, additional, Karanam, Balasubramanyam, additional, Terris, Martha K., additional, Kavuri, Shyam M., additional, Lerner, Seth P., additional, Kheradmand, Farrah, additional, Coarfa, Cristian, additional, Sreekumar, Arun, additional, Lotan, Yair, additional, El-Zein, Randa, additional, and Putluri, Nagireddy, additional

Published
2024
Full Text
View/download PDF

11. Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration

Author

Yoon, Wan Hee, Sandoval, Hector, Nagarkar-Jaiswal, Sonal, Jaiswal, Manish, Yamamoto, Shinya, Haelterman, Nele A, Putluri, Nagireddy, Putluri, Vasanta, Sreekumar, Arun, Tos, Tulay, Aksoy, Ayse, Donti, Taraka, Graham, Brett H, Ohno, Mikiko, Nishi, Eiichiro, Hunter, Jill, Muzny, Donna M, Carmichael, Jason, Shen, Joseph, Arboleda, Valerie A, Nelson, Stanley F, Wangler, Michael F, Karaca, Ender, Lupski, James R, and Bellen, Hugo J

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Neurosciences, Psychology, Neurodegenerative, Genetics, Animals, Autophagy, Drosophila, Drosophila Proteins, Drosophila melanogaster, Ketoglutarate Dehydrogenase Complex, Ketoglutaric Acids, Lysine, Mechanistic Target of Rapamycin Complex 1, Metalloendopeptidases, Mitochondria, Molecular Chaperones, Multiprotein Complexes, Neurodegenerative Diseases, TOR Serine-Threonine Kinases, DNAJA3, NRD1, OGDHL, TCA cycle, alpha-ketoglutarate, autophagy, metabolism, mitochondrial chaperones, rapamycin, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

We previously identified mutations in Nardilysin (dNrd1) in a forward genetic screen designed to isolate genes whose loss causes neurodegeneration in Drosophila photoreceptor neurons. Here we show that NRD1 is localized to mitochondria, where it recruits mitochondrial chaperones and assists in the folding of α-ketoglutarate dehydrogenase (OGDH), a rate-limiting enzyme in the Krebs cycle. Loss of Nrd1 or Ogdh leads to an increase in α-ketoglutarate, a substrate for OGDH, which in turn leads to mTORC1 activation and a subsequent reduction in autophagy. Inhibition of mTOR activity by rapamycin or partially restoring autophagy delays neurodegeneration in dNrd1 mutant flies. In summary, this study reveals a novel role for NRD1 as a mitochondrial co-chaperone for OGDH and provides a mechanistic link between mitochondrial metabolic dysfunction, mTORC1 signaling, and impaired autophagy in neurodegeneration.

Published
2017

12. Thioredoxin reductase is a major regulator of metabolism in leukemia cells

Author

Karunanithi, Sheelarani, Liu, Ruifu, Hou, Yongchun, Gonzalez, Giancarlo, Oldford, Natasha, Roe, Anne Jessica, Idipilly, Nethrie, Gupta, Kalpana, Amara, Chandra Sekhar, Putluri, Satwikreddy, Lee, Grace Kyueun, Valentin-Goyco, Juan, Stetson, Lindsay, Moreton, Stephen A., Putluri, Vasanta, Kavuri, Shyam M., Saunthararajah, Yogen, de Lima, Marcos, Tochtrop, Gregory P., Putluri, Nagireddy, and Wald, David N.

Published
2021
Full Text
View/download PDF

13. Supplementary Material and Methods from Metabolomic Rewiring Promotes Endocrine Therapy Resistance in Breast Cancer

Author

Ahn, Songyeon, primary, Park, Jun Hyoung, primary, Grimm, Sandra L., primary, Piyarathna, Danthasinghe Waduge Badrajee, primary, Samanta, Tagari, primary, Putluri, Vasanta, primary, Mezquita, Dereck, primary, Fuqua, Suzanne A.W., primary, Putluri, Nagireddy, primary, Coarfa, Cristian, primary, and Kaipparettu, Benny Abraham, primary

Published
2024
Full Text
View/download PDF

15. Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer.

Author

Kaushik, Akash, Shojaie, Ali, Panzitt, Katrin, Sonavane, Rajni, Venghatakrishnan, Harene, Manikkam, Mohan, Zaslavsky, Alexander, Putluri, Vasanta, Vasu, Vihas, Zhang, Yiqing, Khan, Ayesha, Lloyd, Stacy, Szafran, Adam, Dasgupta, Subhamoy, Bader, David, Stossi, Fabio, Li, Hangwen, Samanta, Susmita, Cao, Xuhong, Tsouko, Efrosini, Huang, Shixia, Frigo, Daniel, Chan, Lawrence, Edwards, Dean, Kaipparettu, Benny, Mitsiades, Nicholas, Weigel, Nancy, Mancini, Michael, McGuire, Sean, Mehra, Rohit, Ittmann, Michael, Chinnaiyan, Arul, Putluri, Nagireddy, Palapattu, Ganesh, Michailidis, George, and Sreekumar, Arun

Subjects
Animals, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Cell Line, Hexosamines, Humans, Male, Mice, Mice, SCID, Phosphatidylinositol 3-Kinases, Prostatic Neoplasms, Castration-Resistant, Proto-Oncogene Proteins c-akt
Abstract

The precise molecular alterations driving castration-resistant prostate cancer (CRPC) are not clearly understood. Using a novel network-based integrative approach, here, we show distinct alterations in the hexosamine biosynthetic pathway (HBP) to be critical for CRPC. Expression of HBP enzyme glucosamine-phosphate N-acetyltransferase 1 (GNPNAT1) is found to be significantly decreased in CRPC compared with localized prostate cancer (PCa). Genetic loss-of-function of GNPNAT1 in CRPC-like cells increases proliferation and aggressiveness, in vitro and in vivo. This is mediated by either activation of the PI3K-AKT pathway in cells expressing full-length androgen receptor (AR) or by specific protein 1 (SP1)-regulated expression of carbohydrate response element-binding protein (ChREBP) in cells containing AR-V7 variant. Strikingly, addition of the HBP metabolite UDP-N-acetylglucosamine (UDP-GlcNAc) to CRPC-like cells significantly decreases cell proliferation, both in-vitro and in animal studies, while also demonstrates additive efficacy when combined with enzalutamide in-vitro. These observations demonstrate the therapeutic value of targeting HBP in CRPC.

Published
2016

16. Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression

Author

Vantaku, Venkatrao, Putluri, Vasanta, Bader, David A., Maity, Suman, Ma, Jing, Arnold, James M., Rajapakshe, Kimal, Donepudi, Sri Ramya, von Rundstedt, Friedrich-Carl, Devarakonda, Vaishnavi, Dubrulle, Julien, Karanam, Balasubramanyam, McGuire, Sean E., Stossi, Fabio, Jain, Abhinav K., Coarfa, Cristian, Cao, Qi, Sikora, Andrew G., Villanueva, Hugo, Kavuri, Shyam M., Lotan, Yair, Sreekumar, Arun, and Putluri, Nagireddy

Published
2020
Full Text
View/download PDF

17. Correction: Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression

Author

Vantaku, Venkatrao, Putluri, Vasanta, Bader, David A., Maity, Suman, Ma, Jing, Arnold, James M., Rajapakshe, Kimal, Donepudi, Sri Ramya, von Rundstedt, Friedrich-Carl, Devarakonda, Vaishnavi, Dubrulle, Julien, Karanam, Balasubramanyam, McGuire, Sean E., Stossi, Fabio, Jain, Abhinav K., Coarfa, Cristian, Cao, Qi, Sikora, Andrew G., Villanueva, Hugo, Kavuri, Shyam M., Lotan, Yair, Sreekumar, Arun, and Putluri, Nagireddy

Published
2020
Full Text
View/download PDF

18. Metabolomic rewiring promotes endocrine therapy resistance in breast cancer

Author

Ahn, Songyeon, primary, Park, Jun Hyoung., additional, Grimm, Sandra L., additional, Piyarathna, Danthasinghe Waduge Badrajee, additional, Samanta, Tagari, additional, Putluri, Vasanta, additional, Mezquita, Dereck, additional, Fuqua, Suzanne A.W., additional, Putluri, Nagireddy, additional, Coarfa, Cristian, additional, and Kaipparettu, Benny Abraham., additional

Published
2023
Full Text
View/download PDF

20. Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder

Author

Piyarathna, Danthasinghe Waduge Badrajee, Rajendiran, Thekkelnaycke M., Putluri, Vasanta, Vantaku, Venkatrao, Soni, Tanu, von Rundstedt, Friedrich-Carl, Donepudi, Sri Ramya, Jin, Feng, Maity, Suman, Ambati, Chandrashekar R., Dong, Jianrong, Gödde, Daniel, Roth, Stephan, Störkel, Stephan, Degener, Stephan, Michailidis, George, Lerner, Seth P., Pennathur, Subramaniam, Lotan, Yair, Coarfa, Cristian, Sreekumar, Arun, and Putluri, Nagireddy

Published
2018
Full Text
View/download PDF

21. Gnotobiotic Rats Reveal that Gut Microbiota Regulates Colonic mRNA of Ace2, the Receptor for SARS-CoV-2 Infectivity

Author

Yang, Tao, Chakraborty, Saroj, Saha, Piu, Mell, Blair, Cheng, Xi, Yeo, Ji-Youn, Mei, Xue, Zhou, Guannan, Mandal, Juthika, Golonka, Rachel, Yeoh, Beng San, Putluri, Vasanta, Piyarathna, Danthasinghe Waduge Badrajee, Putluri, Nagireddy, McCarthy, Cameron G., Wenceslau, Camilla, Sreekumar, Arun, Gewirtz, Andrew T., Vijay-Kumar, Matam, and Joe, Bina

Published
2020
Full Text
View/download PDF

22. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

Author

Hu, Qingsong, Ye, Youqiong, Chan, Li-Chuan, Li, Yajuan, Liang, Ke, Lin, Aifu, Egranov, Sergey D., Zhang, Yaohua, Xia, Weiya, Gong, Jing, Pan, Yinghong, Chatterjee, Sujash S., Yao, Jun, Evans, Kurt W., Nguyen, Tina K., Park, Peter K., Liu, Jiewei, Coarfa, Cristian, Donepudi, Sri Ramya, Putluri, Vasanta, Putluri, Nagireddy, Sreekumar, Arun, Ambati, Chandrashekar R., Hawke, David H., Marks, Jeffrey R., Gunaratne, Preethi H., Caudle, Abigail S., Sahin, Aysegul A., Hortobagyi, Gabriel N., Meric-Bernstam, Funda, Chen, Lieping, Yu, Dihua, Hung, Mien-Chie, Curran, Michael A., Han, Leng, Lin, Chunru, and Yang, Liuqing

Published
2019
Full Text
View/download PDF

23. Role of Adenosine Deaminase in Prostate Cancer Progression

Author

Charles, Christy, primary, Lloyd, Stacy M, additional, Piyarathna, Danthasinghe Waduge Badrajee, additional, Gohlke, Jie, additional, Rasaily, Uttam, additional, Putluri, Vasanta, additional, Simons, Brian W, additional, Zaslavsky, Alexander, additional, Nallandhighal, Srinivas, additional, Palanisamy, Nallasivam, additional, Navone, Nora, additional, Jones, Jeffrey A, additional, Ittmann, Michael M, additional, Putluri, Nagireddy, additional, Rowley, David R, additional, Salami, Simpa S, additional, Palapattu, Ganesh, additional, and Sreekumar, Arun, additional

Published
2023
Full Text
View/download PDF

24. Vitamin B2 enables regulation of fasting glucose availability

Author

Masschelin, Peter M, primary, Saha, Pradip, additional, Ochsner, Scott A, additional, Cox, Aaron R, additional, Kim, Kang Ho, additional, Felix, Jessica B, additional, Sharp, Robert, additional, Li, Xin, additional, Tan, Lin, additional, Park, Jun Hyoung, additional, Wang, Liping, additional, Putluri, Vasanta, additional, Lorenzi, Philip L, additional, Nuotio-Antar, Alli M, additional, Sun, Zheng, additional, Kaipparettu, Benny Abraham, additional, Putluri, Nagireddy, additional, Moore, David D, additional, Summers, Scott A, additional, McKenna, Neil J, additional, and Hartig, Sean M, additional

Published
2023
Full Text
View/download PDF

25. ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming

Author

Mishra, Prachi, Tang, Wei, Putluri, Vasanta, Dorsey, Tiffany H., Jin, Feng, Wang, Fang, Zhu, Donewei, Amable, Lauren, Deng, Tao, Zhang, Shaofei, Killian, J. Keith, Wang, Yonghong, Minas, Tsion Z., Yfantis, Harry G., Lee, Dong H., Sreekumar, Arun, Bustin, Michael, Liu, Wei, Putluri, Nagireddy, and Ambs, Stefan

Subjects
Epigenetic inheritance -- Physiological aspects, Glutamine -- Physiological aspects, Metabolites -- Physiological aspects, Breast cancer -- Genetic aspects -- Development and progression -- Physiological aspects -- Research, Health care industry
Abstract

Metabolic reprogramming in breast tumors is linked to increases in putative oncogenic metabolites that may contribute to malignant transformation. We previously showed that accumulation of the oncometabolite, 2-hydroxyglutarate (2HG), in breast tumors was associated with MYC signaling, but not with isocitrate dehydrogenase (IDH) mutations, suggesting a distinct mechanism for increased 2HG in breast cancer. Here, we determined that D-2HG is the predominant enantiomer in human breast tumors and show that the D-2HG-producing mitochondrial enzyme, alcohol dehydrogenase, iron-containing protein 1 (ADHFE1), is a breast cancer oncogene that decreases patient survival. We found that MYC upregulates ADHFE1 through changes in iron metabolism while coexpression of both ADHFE1 and MYC strongly enhanced orthotopic tumor growth in MCF7 cells. Moreover, ADHFE1 promoted metabolic reprogramming with increased formation of D-2HG and reactive oxygen, a reductive glutamine metabolism, and modifications of the epigenetic landscape, leading to cellular dedifferentiation, enhanced mesenchymal transition, and phenocopying alterations that occur with high D-2HG levels in cancer cells with IDH mutations. Together, our data support the hypothesis that ADHFE1 and MYC signaling contribute to D-2HG accumulation in breast tumors and show that D-2HG is an oncogenic metabolite and potential driver of disease progression., Introduction Breast tumors undergo metabolic reprogramming as part of malignant transformation (1, 2). This reprogramming leads to increased availability of putative oncogenic metabolites that are used for the synthesis of [...]

Published
2018
Full Text
View/download PDF

26. Conjugated bile acids are nutritionally re-programmable antihypertensive metabolites

Author

Chakraborty, Saroj, primary, Lulla, Anju, additional, Cheng, Xi, additional, Yeo, Ji-Youn, additional, Mandal, Juthika, additional, Yang, Tao, additional, Mei, Xue, additional, Saha, Piu, additional, Golonka, Rachel M., additional, Yeoh, Beng San, additional, Mell, Blair, additional, Jia, Wei, additional, Putluri, Vasanta, additional, Piyarathna, Danthasinghe Waduge Badrajee, additional, Putluri, Nagireddy, additional, Sreekumar, Arun, additional, Meyer, Katie, additional, Vijay-Kumar, Matam, additional, and Joe, Bina, additional

Published
2023
Full Text
View/download PDF

27. Data from A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women

Author

Jiao, Li, primary, Maity, Suman, primary, Coarfa, Cristian, primary, Rajapakshe, Kimal, primary, Chen, Liang, primary, Jin, Feng, primary, Putluri, Vasanta, primary, Tinker, Lesley F., primary, Mo, Qianxing, primary, Chen, Fengju, primary, Sen, Subrata, primary, Sangi-Hyghpeykar, Haleh, primary, El-Serag, Hashem B., primary, and Putluri, Nagireddy, primary

Published
2023
Full Text
View/download PDF

28. Supplementary Figure 3 from A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women

Author

Jiao, Li, primary, Maity, Suman, primary, Coarfa, Cristian, primary, Rajapakshe, Kimal, primary, Chen, Liang, primary, Jin, Feng, primary, Putluri, Vasanta, primary, Tinker, Lesley F., primary, Mo, Qianxing, primary, Chen, Fengju, primary, Sen, Subrata, primary, Sangi-Hyghpeykar, Haleh, primary, El-Serag, Hashem B., primary, and Putluri, Nagireddy, primary

Published
2023
Full Text
View/download PDF

29. Supplementary Figure Legends from A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women

Author

Jiao, Li, primary, Maity, Suman, primary, Coarfa, Cristian, primary, Rajapakshe, Kimal, primary, Chen, Liang, primary, Jin, Feng, primary, Putluri, Vasanta, primary, Tinker, Lesley F., primary, Mo, Qianxing, primary, Chen, Fengju, primary, Sen, Subrata, primary, Sangi-Hyghpeykar, Haleh, primary, El-Serag, Hashem B., primary, and Putluri, Nagireddy, primary

Published
2023
Full Text
View/download PDF

30. Supplementary Figure 2 from A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women

Author

Jiao, Li, primary, Maity, Suman, primary, Coarfa, Cristian, primary, Rajapakshe, Kimal, primary, Chen, Liang, primary, Jin, Feng, primary, Putluri, Vasanta, primary, Tinker, Lesley F., primary, Mo, Qianxing, primary, Chen, Fengju, primary, Sen, Subrata, primary, Sangi-Hyghpeykar, Haleh, primary, El-Serag, Hashem B., primary, and Putluri, Nagireddy, primary

Published
2023
Full Text
View/download PDF

31. Supplementary Table 1 from A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women

Author

Jiao, Li, primary, Maity, Suman, primary, Coarfa, Cristian, primary, Rajapakshe, Kimal, primary, Chen, Liang, primary, Jin, Feng, primary, Putluri, Vasanta, primary, Tinker, Lesley F., primary, Mo, Qianxing, primary, Chen, Fengju, primary, Sen, Subrata, primary, Sangi-Hyghpeykar, Haleh, primary, El-Serag, Hashem B., primary, and Putluri, Nagireddy, primary

Published
2023
Full Text
View/download PDF

32. Supplementary Figure 1 from A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women

Author

Jiao, Li, primary, Maity, Suman, primary, Coarfa, Cristian, primary, Rajapakshe, Kimal, primary, Chen, Liang, primary, Jin, Feng, primary, Putluri, Vasanta, primary, Tinker, Lesley F., primary, Mo, Qianxing, primary, Chen, Fengju, primary, Sen, Subrata, primary, Sangi-Hyghpeykar, Haleh, primary, El-Serag, Hashem B., primary, and Putluri, Nagireddy, primary

Published
2023
Full Text
View/download PDF

33. Supplementary Material from A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women

Author

Jiao, Li, primary, Maity, Suman, primary, Coarfa, Cristian, primary, Rajapakshe, Kimal, primary, Chen, Liang, primary, Jin, Feng, primary, Putluri, Vasanta, primary, Tinker, Lesley F., primary, Mo, Qianxing, primary, Chen, Fengju, primary, Sen, Subrata, primary, Sangi-Hyghpeykar, Haleh, primary, El-Serag, Hashem B., primary, and Putluri, Nagireddy, primary

Published
2023
Full Text
View/download PDF

34. Integrative Pathway Analysis of Metabolic Signature in Bladder Cancer: A Linkage to The Cancer Genome Atlas Project and Prediction of Survival

Author

von Rundstedt, Friedrich-Carl, Rajapakshe, Kimal, Ma, Jing, Arnold, James M., Gohlke, Jie, Putluri, Vasanta, Krishnapuram, Rashmi, Piyarathna, D. Badrajee, Lotan, Yair, Gödde, Daniel, Roth, Stephan, Störkel, Stephan, Levitt, Jonathan M., Michailidis, George, Sreekumar, Arun, Lerner, Seth P., Coarfa, Cristian, and Putluri, Nagireddy

Published
2016
Full Text
View/download PDF

35. Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

Author

Park, Jun Hyoung, Vithayathil, Sajna, Kumar, Santosh, Sung, Pi-Lin, Dobrolecki, Lacey Elizabeth, Putluri, Vasanta, Bhat, Vadiraja B., Bhowmik, Salil Kumar, Gupta, Vineet, Arora, Kavisha, Wu, Danli, Tsouko, Efrosini, Zhang, Yiqun, Maity, Suman, Donti, Taraka R., Graham, Brett H., Frigo, Daniel E., Coarfa, Cristian, Yotnda, Patricia, Putluri, Nagireddy, Sreekumar, Arun, Lewis, Michael T., Creighton, Chad J., Wong, Lee-Jun C., and Kaipparettu, Benny Abraham

Published
2016
Full Text
View/download PDF

38. Data from Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer

Author

Xing, Zhen, primary, Zhang, Yanyan, primary, Liang, Ke, primary, Yan, Liang, primary, Xiang, Yu, primary, Li, Chunlai, primary, Hu, Qingsong, primary, Jin, Feng, primary, Putluri, Vasanta, primary, Putluri, Nagireddy, primary, Coarfa, Cristian, primary, Sreekumar, Arun, primary, Park, Peter K., primary, Nguyen, Tina K., primary, Wang, Shouyu, primary, Zhou, Jianwei, primary, Zhou, Yan, primary, Marks, Jeffrey R., primary, Hawke, David H., primary, Hung, Mien-Chie, primary, Yang, Liuqing, primary, Han, Leng, primary, Ying, Haoqiang, primary, and Lin, Chunru, primary

Published
2023
Full Text
View/download PDF

40. Supplementary Figure S5 from Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer

Author

Vantaku, Venkatrao, primary, Dong, Jianrong, primary, Ambati, Chandrashekar R., primary, Perera, Dimuthu, primary, Donepudi, Sri Ramya, primary, Amara, Chandra Sekhar, primary, Putluri, Vasanta, primary, Ravi, Shiva Shankar, primary, Robertson, Matthew J., primary, Piyarathna, Danthasinghe Waduge Badrajee, primary, Villanueva, Mariana, primary, von Rundstedt, Friedrich-Carl, primary, Karanam, Balasubramanyam, primary, Ballester, Leomar Y., primary, Terris, Martha K., primary, Bollag, Roni J., primary, Lerner, Seth P., primary, Apolo, Andrea B., primary, Villanueva, Hugo, primary, Lee, MinJae, primary, Sikora, Andrew G., primary, Lotan, Yair, primary, Sreekumar, Arun, primary, Coarfa, Cristian, primary, and Putluri, Nagireddy, primary

Published
2023
Full Text
View/download PDF

42. Supplement Table S5 from Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer

Author

Vantaku, Venkatrao, primary, Dong, Jianrong, primary, Ambati, Chandrashekar R., primary, Perera, Dimuthu, primary, Donepudi, Sri Ramya, primary, Amara, Chandra Sekhar, primary, Putluri, Vasanta, primary, Ravi, Shiva Shankar, primary, Robertson, Matthew J., primary, Piyarathna, Danthasinghe Waduge Badrajee, primary, Villanueva, Mariana, primary, von Rundstedt, Friedrich-Carl, primary, Karanam, Balasubramanyam, primary, Ballester, Leomar Y., primary, Terris, Martha K., primary, Bollag, Roni J., primary, Lerner, Seth P., primary, Apolo, Andrea B., primary, Villanueva, Hugo, primary, Lee, MinJae, primary, Sikora, Andrew G., primary, Lotan, Yair, primary, Sreekumar, Arun, primary, Coarfa, Cristian, primary, and Putluri, Nagireddy, primary

Published
2023
Full Text
View/download PDF

44. Supplementary Data from Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer

Author

Xing, Zhen, primary, Zhang, Yanyan, primary, Liang, Ke, primary, Yan, Liang, primary, Xiang, Yu, primary, Li, Chunlai, primary, Hu, Qingsong, primary, Jin, Feng, primary, Putluri, Vasanta, primary, Putluri, Nagireddy, primary, Coarfa, Cristian, primary, Sreekumar, Arun, primary, Park, Peter K., primary, Nguyen, Tina K., primary, Wang, Shouyu, primary, Zhou, Jianwei, primary, Zhou, Yan, primary, Marks, Jeffrey R., primary, Hawke, David H., primary, Hung, Mien-Chie, primary, Yang, Liuqing, primary, Han, Leng, primary, Ying, Haoqiang, primary, and Lin, Chunru, primary

Published
2023
Full Text
View/download PDF

45. Supplemental legend from Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer

Author

Vantaku, Venkatrao, primary, Dong, Jianrong, primary, Ambati, Chandrashekar R., primary, Perera, Dimuthu, primary, Donepudi, Sri Ramya, primary, Amara, Chandra Sekhar, primary, Putluri, Vasanta, primary, Ravi, Shiva Shankar, primary, Robertson, Matthew J., primary, Piyarathna, Danthasinghe Waduge Badrajee, primary, Villanueva, Mariana, primary, von Rundstedt, Friedrich-Carl, primary, Karanam, Balasubramanyam, primary, Ballester, Leomar Y., primary, Terris, Martha K., primary, Bollag, Roni J., primary, Lerner, Seth P., primary, Apolo, Andrea B., primary, Villanueva, Hugo, primary, Lee, MinJae, primary, Sikora, Andrew G., primary, Lotan, Yair, primary, Sreekumar, Arun, primary, Coarfa, Cristian, primary, and Putluri, Nagireddy, primary

Published
2023
Full Text
View/download PDF

47. Data from Metabolomic Profiling Reveals Potential Markers and Bioprocesses Altered in Bladder Cancer Progression

Author

Putluri, Nagireddy, primary, Shojaie, Ali, primary, Vasu, Vihas T., primary, Vareed, Shaiju K., primary, Nalluri, Srilatha, primary, Putluri, Vasanta, primary, Thangjam, Gagan Singh, primary, Panzitt, Katrin, primary, Tallman, Christopher T., primary, Butler, Charles, primary, Sana, Theodore R., primary, Fischer, Steven M., primary, Sica, Gabriel, primary, Brat, Daniel J., primary, Shi, Huidong, primary, Palapattu, Ganesh S., primary, Lotan, Yair, primary, Weizer, Alon Z., primary, Terris, Martha K., primary, Shariat, Shahrokh F., primary, Michailidis, George, primary, and Sreekumar, Arun, primary

Published
2023
Full Text
View/download PDF

48. Supplementary Methods, Figures 1-5, Tables 1-11 from Metabolomic Profiling Reveals Potential Markers and Bioprocesses Altered in Bladder Cancer Progression

Author

Putluri, Nagireddy, primary, Shojaie, Ali, primary, Vasu, Vihas T., primary, Vareed, Shaiju K., primary, Nalluri, Srilatha, primary, Putluri, Vasanta, primary, Thangjam, Gagan Singh, primary, Panzitt, Katrin, primary, Tallman, Christopher T., primary, Butler, Charles, primary, Sana, Theodore R., primary, Fischer, Steven M., primary, Sica, Gabriel, primary, Brat, Daniel J., primary, Shi, Huidong, primary, Palapattu, Ganesh S., primary, Lotan, Yair, primary, Weizer, Alon Z., primary, Terris, Martha K., primary, Shariat, Shahrokh F., primary, Michailidis, George, primary, and Sreekumar, Arun, primary

Published
2023
Full Text
View/download PDF

49. Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability

Author

Masschelin, Peter M., primary, Saha, Pradip K., additional, Ochsner, Scott A., additional, Cox, Aaron R., additional, Kim, Kang Ho, additional, Felix, Jessica B., additional, Sharp, Robert, additional, Li, Xin, additional, Tan, Lin, additional, Park, Jun Hyoung, additional, Wang, Liping, additional, Putluri, Vasanta, additional, Lorenzi, Philip L., additional, Nuotio-Antar, Alli M., additional, Sun, Zheng, additional, Kaipparettu, Benny, additional, Putluri, Nagireddy, additional, Moore, David D., additional, Summers, Scott A., additional, McKenna, Neil J., additional, and Hartig, Sean M., additional

Published
2022
Full Text
View/download PDF

50. Pathway-Centric Integrative Analysis Identifies RRM2 as a Prognostic Marker in Breast Cancer Associated with Poor Survival and Tamoxifen Resistance

Author

Putluri, Nagireddy, Maity, Suman, Kommagani, Ramakrishna, Creighton, Chad J., Putluri, Vasanta, Chen, Fengju, Nanda, Sarmishta, Bhowmik, Salil Kumar, Terunuma, Atsushi, Dorsey, Tiffany, Nardone, Agostina, Fu, Xiaoyong, Shaw, Chad, Sarkar, Tapasree Roy, Schiff, Rachel, Lydon, John P., O’Malley, Bert W., Ambs, Stefan, Das, Gokul M., Michailidis, George, and Sreekumar, Arun

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results