152 results on '"Pussinen, P. J."'
Search Results
2. HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes
- Author
-
Odermarsky, Michal, Pesonen, Erkki, Sorsa, Timo, Lernmark, Åke, Pussinen, Pirkko J., and Liuba, Petru
- Published
- 2017
- Full Text
- View/download PDF
3. Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium.
- Author
-
Divaris, K, Haworth, S, Shaffer, J R, Anttonen, V, Beck, J D, Furuichi, Y, Holtfreter, B, Jönsson, Daniel, Kocher, T, Levy, S M, Magnusson, P K E, McNeil, D W, Michaëlsson, K, North, K E, Palotie, U, Papapanou, P N, Pussinen, P J, Porteous, D, Reis, K, Salminen, A, Schaefer, A S, Sudo, T, Sun, Y Q, Suominen, A L, Tamahara, T, Weinberg, S M, Lundberg, P, Marazita, M L, Johansson, I, Divaris, K, Haworth, S, Shaffer, J R, Anttonen, V, Beck, J D, Furuichi, Y, Holtfreter, B, Jönsson, Daniel, Kocher, T, Levy, S M, Magnusson, P K E, McNeil, D W, Michaëlsson, K, North, K E, Palotie, U, Papapanou, P N, Pussinen, P J, Porteous, D, Reis, K, Salminen, A, Schaefer, A S, Sudo, T, Sun, Y Q, Suominen, A L, Tamahara, T, Weinberg, S M, Lundberg, P, Marazita, M L, and Johansson, I
- Abstract
Genetic risk factors play important roles in the etiology of oral, dental, and craniofacial diseases. Identifying the relevant risk loci and understanding their molecular biology could highlight new prevention and management avenues. Our current understanding of oral health genomics suggests that dental caries and periodontitis are polygenic diseases, and very large sample sizes and informative phenotypic measures are required to discover signals and adequately map associations across the human genome. In this article, we introduce the second wave of the Gene-Lifestyle Interactions and Dental Endpoints consortium (GLIDE2) and discuss relevant data analytics challenges, opportunities, and applications. In this phase, the consortium comprises a diverse, multiethnic sample of over 700,000 participants from 21 studies contributing clinical data on dental caries experience and periodontitis. We outline the methodological challenges of combining data from heterogeneous populations, as well as the data reduction problem in resolving detailed clinical examination records into tractable phenotypes, and describe a strategy that addresses this. Specifically, we propose a 3-tiered phenotyping approach aimed at leveraging both the large sample size in the consortium and the detailed clinical information available in some studies, wherein binary, severity-encompassing, and "precision," data-driven clinical traits are employed. As an illustration of the use of data-driven traits across multiple cohorts, we present an application of dental caries experience data harmonization in 8 participating studies (N = 55,143) using previously developed permanent dentition tooth surface-level dental caries pattern traits. We demonstrate that these clinical patterns are transferable across multiple cohorts, have similar relative contributions within each study, and thus are prime targets for genetic interrogation in the expanded and diverse multiethnic sample of GLIDE2. We anticipate that resul
- Published
- 2022
- Full Text
- View/download PDF
4. Salivary IgA antibody to malondialdehyde–acetaldehyde associates with mild periodontal pocket depth
- Author
-
Akhi, R. (Ramin), Nissinen, A. E. (Antti E.), Wang, C. (Chunguang), Kyrklund, M. (Mikael), Paju, S. (Susanna), Mäntylä, P. (Päivi), Buhlin, K. (Kåre), Sinisalo, J. (Juha), Pussinen, P. J. (Pirkko J.), Hörkkö, S. (Sohvi), Akhi, R. (Ramin), Nissinen, A. E. (Antti E.), Wang, C. (Chunguang), Kyrklund, M. (Mikael), Paju, S. (Susanna), Mäntylä, P. (Päivi), Buhlin, K. (Kåre), Sinisalo, J. (Juha), Pussinen, P. J. (Pirkko J.), and Hörkkö, S. (Sohvi)
- Abstract
Objective: Oxidized epitopes such as malondialdehyde–acetaldehyde (MAA) play a crucial role in the progression of atherosclerosis through activation of the humoral immune response. The exact mechanism of the association between atherosclerosis and periodontal diseases is not fully understood. The aim of the current study is to evaluate the association of oral humoral immune response to oxidized epitopes with parameters of periodontal disease. Materials and methods: The Parogene cohort consist of patients who have undergone coronary angiography due to cardiac symptoms. In this study, 423 patients were randomly selected for an extensive oral examination. Salivary Immunoglobulin A to oxidized epitopes and bacterial antigens was determined by chemiluminescence immunoassay. Results: In a binary logistic regression model adjusted with periodontal disease confounders, periodontal pocket depth (PPD) 4–5 mm associated with salivary IgA antibodies to MAA-LDL (p = 0.034), heat shock protein 60 of Aggregatibacter actinomycetemcomitans (p = 0.045), Porphyromonas gingivalis (p = 0.045), A. actinomycetemcomitans (p = 0.005), P. intermedia (p = 0.020), and total IgA (p = 0.003). Conclusions: The current study shows the association of salivary IgA to MAA-LDL with PPD 4–5 mm in a cohort of patients with chronic coronary artery disease. Humoral immune cross-reactivation to oxidized epitopes such MAA-LDL could partly explain the link of periodontitis with systemic diseases.
- Published
- 2022
5. Mannose‐binding lectin gene polymorphism in relation to periodontal infection
- Author
-
Liukkonen, A., He, Q., Gürsoy, U. K., Pussinen, P. J., Gröndahl‐Yli‐Hannuksela, K., Liukkonen, J., Sorsa, T., Suominen, A. L., Huumonen, S., and Könönen, E.
- Published
- 2017
- Full Text
- View/download PDF
6. Endotoxemia, nutrition, and cardiometabolic disorders
- Author
-
Kallio, K. A. Elisa, Hätönen, Katja A., Lehto, Markku, Salomaa, Veikko, Männistö, Satu, and Pussinen, Pirkko J.
- Published
- 2015
- Full Text
- View/download PDF
7. Systemic exposure to a common periodontal pathogen and missing teeth are associated with metabolic syndrome
- Author
-
Hyvärinen, K., Salminen, A., Salomaa, V., and Pussinen, P. J.
- Published
- 2015
- Full Text
- View/download PDF
8. The effect of prolonged systemic doxycycline therapy on serum tissue degrading proteinases in coronary bypass patients: a randomized, double-masked, placebo-controlled clinical trial
- Author
-
Kormi, Immi, Alfakry, Hatem, Tervahartiala, Taina, Pussinen, Pirkko J., Sinisalo, Juha, and Sorsa, Timo
- Published
- 2014
- Full Text
- View/download PDF
9. Common complement factor H polymorphisms are linked with periodontitis in elderly patients.
- Author
-
Salminen, Aino, Pietiäinen, Milla, Paju, Susanna, Sorsa, Timo, Mäntylä, Päivi, Buhlin, Kåre, Sinisalo, Juha, and Pussinen, Pirkko J.
- Abstract
Background: In our recent genome-wide association study, we found that genetic polymorphisms in the complement factor H (CFH) gene and S100A gene region are strongly associated with serum matrix metalloproteinase 8 (MMP-8) concentration and the release of MMP-8 from neutrophils. As MMP-8 is centrally involved in the pathogenesis of periodontitis, we aimed to evaluate the presence of genetic polymorphisms of S100A8/A9/A12, MMP8, and CFH in periodontitis. In addition, we studied whether polymorphisms of these genes affect the concentrations of S100A8, S100A12, MMP-8, or complement activation marker in saliva.Methods: We genotyped four single-nucleotide polymorphisms (SNPs, rs1560833 in S100A8/A9/A12, rs11225395 in MMP8, rs800292 in CFH, and rs1061170 in CFH) and measured salivary concentrations of S100A8, S100A12, MMP-8, and terminal complement complex (TCC) in the Parogene cohort (n = 508). The cohort was composed of patients with an indication to coronary angiography and all underwent a clinical and radiographic oral examination.Results: CFH polymorphisms rs800292 and rs1061170 were associated with periodontal parameters. None of the polymorphisms showed association with salivary proteins. However, salivary concentrations of S100A8, S100A12, MMP-8, and TCC were strongly associated with the number of periodontal pockets and alveolar bone loss.Conclusion: Interestingly, genetic variants of CFH, MMP8, and S100A8/A9/A12 gene regions did not affect salivary levels of measured proteins. However, saliva levels of S100A8, S100A12, MMP-8, and TCC, and CFH polymorphisms were associated with clinical and radiographic signs of periodontitis. Our study further supports the observations that any dysregulation of complement may increase the risk of inflammatory disorders, such as periodontitis. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
10. Periodontal conditions and incident dementia: A nationwide Swedish cohort study.
- Author
-
Holmer, Jacob, Eriksdotter, Maria, Häbel, Henrike, Hed Myrberg, Ida, Jonsson, Anton, Pussinen, Pirkko J., Garcia‐Ptacek, Sara, Jansson, Leif, Sandborgh‐Englund, Gunilla, Buhlin, Kåre, Garcia-Ptacek, Sara, and Sandborgh-Englund, Gunilla
- Abstract
Background: Periodontal disease has been proposed as a putative etiological factor for dementia. The aim of this investigation was to compare the incidence of dementia in individuals with or without deep probing pocket depths (DPPD), serving as a proxy for periodontitis.Methods: In this cohort study, conducted in Sweden, we identified 7992 individuals with DPPD and 29,182 matched individuals without DPPD (non-DPPD), using the Swedish Quality Registry for Caries and Periodontal Diseases (SKaPa). The two groups were followed for incident dementia (mean follow-up time was 7.6 years) based on data from the Swedish Dementia Registry (SveDem). The exposure-outcome relationship was explored by applying the Royston-Parmar (RP) flexible parametric survival model.Results: The incidence of dementia in the two groups was similar. In the DPPD group 137 (1.7%) developed dementia and 470 (1.6%) in the non-DPPD group. The incidence rate of dementia was estimated to be 2.3 per 1000 person-years (95% confidence interval [CI] 1.9 to 2.7) in the DPPD group and 2.1 per 1000 person-years (95% CI 1.9 to 2.3) in the non-DPPD group. The RP model disclosed no association between DPPD and dementia incidence after controlling for potential confounders (the exponentiated coefficient was estimated to 1.13 [95% CI = 0.39 to 3.24]).Conclusion: In this sample, no association was revealed between deep probing pocket depths and the incidence of dementia. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
11. Subantimicrobial-dose doxycycline treatment increases serum cholesterol efflux capacity from macrophages
- Author
-
Salminen, Aino, Pussinen, Pirkko J., Payne, Jeffrey B., Stoner, Julie A., Jauhiainen, Matti, Golub, Lorne M., Lee, Hsi-Ming, Thompson, David M., and Sorsa, Timo
- Published
- 2013
- Full Text
- View/download PDF
12. Systemic exposure to Pseudomonal bacteria: a potential link between type 1 diabetes and chronic inflammation
- Author
-
Peräneva, Lina, Fogarty, Christopher L., Pussinen, Pirkko J., Forsblom, Carol, Groop, Per-Henrik, and Lehto, Markku
- Published
- 2013
- Full Text
- View/download PDF
13. Response to Letter to Editor regarding article, ‘Association between dental factors and mortality’
- Author
-
Liljestrand, J. M., primary, Salminen, A., additional, and Pussinen, P. J., additional
- Published
- 2021
- Full Text
- View/download PDF
14. Systemic antibiotics influence periodontal parameters and oral microbiota, but not serological markers
- Author
-
Kopra, E. (Elisa), Lahdentausta, L. (Laura), Pietiäinen, M. (Milla), Buhlin, K. (Kåre), Mäntylä, P. (Päivi), Hörkkö, S. (Sohvi), Persson, R. (Rutger), Paju, S. (Susanna), Sinisalo, J. (Juha), Salminen, A. (Aino), Pussinen, P. J. (Pirkko J.), Kopra, E. (Elisa), Lahdentausta, L. (Laura), Pietiäinen, M. (Milla), Buhlin, K. (Kåre), Mäntylä, P. (Päivi), Hörkkö, S. (Sohvi), Persson, R. (Rutger), Paju, S. (Susanna), Sinisalo, J. (Juha), Salminen, A. (Aino), and Pussinen, P. J. (Pirkko J.)
- Abstract
The use of systemic antibiotics may influence the oral microbiota composition. Our aim was to investigate in this retrospective study whether the use of prescribed antibiotics associate with periodontal status, oral microbiota, and antibodies against the periodontal pathogens. The Social Insurance Institution of Finland Data provided the data on the use of systemic antibiotics by record linkage to purchased medications and entitled reimbursements up to 1 year before the oral examination and sampling. Six different classes of antibiotics were considered. The Parogene cohort included 505 subjects undergoing coronary angiography with the mean (SD) age of 63.4 (9.2) years and 65% of males. Subgingival plaque samples were analysed using the checkerboard DNA-DNA hybridisation. Serum and saliva antibody levels to periodontal pathogens were analysed with immunoassays and lipopolysaccharide (LPS) activity with the LAL assay. Systemic antibiotics were prescribed for 261 (51.7%) patients during the preceding year. The mean number of prescriptions among them was 2.13 (range 1–12), and 29.4% of the prescriptions were cephalosporins, 25.7% penicillins, 14.3% quinolones, 12.7% macrolides or lincomycin, 12.0% tetracycline, and 5.8% trimethoprim or sulphonamides. In linear regression models adjusted for age, sex, current smoking, and diabetes, number of antibiotic courses associated significantly with low periodontal inflammation burden index (PIBI, p < 0.001), bleeding on probing (BOP, p = 0.006), and alveolar bone loss (ABL, p = 0.042). Cephalosporins associated with all the parameters. The phyla mainly affected by the antibiotics were Bacteroidetes and Spirochaetes. Their levels were inversely associated with the number of prescriptions (p = 0.010 and p < 0.001) and directly associated with the time since the last prescription (p = 0.019 and p < 0.001). Significant inverse associations were observed between the number of prescriptions and saliva concentrations o
- Published
- 2021
15. Carotid artery calcification in panoramic radiographs associates with oral infections and mortality
- Author
-
Paju, S., primary, Pietiäinen, M., additional, Liljestrand, J. M., additional, Lahdentausta, L., additional, Salminen, A., additional, Kopra, E., additional, Mäntylä, P., additional, Buhlin, K., additional, Hörkkö, S., additional, Sinisalo, J., additional, and Pussinen, P. J., additional
- Published
- 2021
- Full Text
- View/download PDF
16. Immunological and microbiological profiling of cumulative risk score for periodontitis
- Author
-
Liukkonen, J. (Joonas), Gürsoy, U. K. (Ulvi K.), Könönen, E. (Eija), Akhi, R. (Ramin), Salminen, A. (Aino), Liljestrand, J. M. (John M.), Pradhan-Palikhe, P. (Pratikshya), Pietiäinen, M. (Milla), Sorsa, T. (Timo), Persson, G. R. (G. Rutger), Mäntylä, P. (Päivi), Buhlin, K. (Kåre), Paju, S. (Susanna), Sinisalo, J. (Juha), Hörkkö, S. (Sohvi), Pussinen, P. J. (Pirkko J.), Liukkonen, J. (Joonas), Gürsoy, U. K. (Ulvi K.), Könönen, E. (Eija), Akhi, R. (Ramin), Salminen, A. (Aino), Liljestrand, J. M. (John M.), Pradhan-Palikhe, P. (Pratikshya), Pietiäinen, M. (Milla), Sorsa, T. (Timo), Persson, G. R. (G. Rutger), Mäntylä, P. (Päivi), Buhlin, K. (Kåre), Paju, S. (Susanna), Sinisalo, J. (Juha), Hörkkö, S. (Sohvi), and Pussinen, P. J. (Pirkko J.)
- Abstract
The cumulative risk score (CRS) is a mathematical salivary diagnostic model to define an individual’s risk of having periodontitis. In order to further validate this salivary biomarker, we investigated how periodontal bacteria, lipopolysaccharide (LPS), and systemic and local host immune responses relate to CRS. Subgingival plaque, saliva, and serum samples collected from 445 individuals were used in the analyses. Plaque levels of 28 microbial species, especially those of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella intermedia, and Tannerella forsythia, and serum and salivary levels of IgA and IgG against these five species were determined. Additionally, LPS activity was measured. High CRS associated strongly with all IgA/IgG antibody and LPS levels in saliva, whereas in serum the associations were not that obvious. In the final logistic regression model, the best predictors of high CRS were saliva IgA burden against the five species (OR 7.04, 95% CI 2.25–22.0), IgG burden (3.79, 1.78–8.08), LPS (2.19, 1.38–3.47), and the sum of 17 subgingival Gram-negative species (6.19, 2.10–18.3). CRS is strongly associated with microbial biomarker species of periodontitis and salivary humoral immune responses against them.
- Published
- 2020
17. Association between dental factors and mortality
- Author
-
Liljestrand, J. M., primary, Salminen, A., additional, Lahdentausta, L., additional, Paju, S., additional, Mäntylä, P., additional, Buhlin, K., additional, Tjäderhane, L., additional, Sinisalo, J., additional, and Pussinen, P. J., additional
- Published
- 2020
- Full Text
- View/download PDF
18. Acute myocardial infarction elevates serine protease activity in saliva of patients with periodontitis
- Author
-
Mäntylä, P., Buduneli, E., Emingil, G., Tervahartiala, T., Pussinen, P. J., Barş, N., Akll, A., Atilla, G., and Sorsa, T.
- Published
- 2012
- Full Text
- View/download PDF
19. Subgingival Aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease: P0706
- Author
-
Mäntylä, P., Buhlin, K., Paju, S., Persson, R. G., Nieminen, M. S., Sinisalo, J., and Pussinen, P. J.
- Published
- 2012
20. SALIVARY MARKERS OF TYPE I COLLAGEN DEGRADATION IN PERIODONTITIS: P0618
- Author
-
Gürsoy, U. K., Könönen, E., Tervahartiala, T., Suominen, A. L., Pussinen, P. J., and Sorsa, T.
- Published
- 2012
21. Saliva levels of Aggregatibacter actin-omycetemcomitans associate with both acute and stable coronary syndrome: RC 118
- Author
-
Hyvärinen, K., Mäntylä, P., Buhlin, K., Paju, S., Nieminen, M. S., Sinisalo, J., and Pussinen, P. J.
- Published
- 2012
22. Periodontopathogen- and Host-Derived Immune Response in Acute Coronary Syndrome
- Author
-
Alfakry, H., Paju, S., Sinisalo, J., Nieminen, M. S., Valtonen, V., Saikku, P., Leinonen, M., and Pussinen, P. J.
- Published
- 2011
- Full Text
- View/download PDF
23. Carotid artery calcification in panoramic radiographs associates with oral infections and mortality
- Author
-
Paju, S., primary, Pietiäinen, M., additional, Liljestrand, J. M., additional, Lahdentausta, L., additional, Salminen, A., additional, Kopra, E., additional, Mäntylä, P., additional, Buhlin, K., additional, Hörkkö, S., additional, Sinisalo, J., additional, and Pussinen, P. J., additional
- Published
- 2020
- Full Text
- View/download PDF
24. Elevated MMP-8 and Decreased Myeloperoxidase Concentrations Associate Significantly with the Risk for Peripheral Atherosclerosis Disease and Abdominal Aortic Aneurysm
- Author
-
Pradhan-Palikhe, P., Vikatmaa, P., Lajunen, T., Palikhe, A., Lepäntalo, M., Tervahartiala, T., Salo, T., Saikku, P., Leinonen, M., Pussinen, P. J., and Sorsa, T.
- Published
- 2010
- Full Text
- View/download PDF
25. Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients with coronary artery disease
- Author
-
Palikhe, A., Lokki, M.-L., Pussinen, P. J., Paju, S., Ahlberg, J., Asikainen, S., Seppänen, M., Valtonen, V., Nieminen, M. S., and Sinisalo, J.
- Published
- 2008
26. Saliva and serum immune responses in apical periodontitis
- Author
-
Pietiäinen, M. (Milla), Liljestrand, J. M. (John M.), Akhi, R. (Ramin), Buhlin, K. (Kåre), Johansson, A. (Anders), Paju, S. (Susanna), Salminen, A. (Aino), Mäntylä, P. (Päivi), Sinisalo, J. (Juha), Tjäderhane, L. (Leo), Hörkkö, S. (Sohvi), Pussinen, P. J. (Pirkko J.), Pietiäinen, M. (Milla), Liljestrand, J. M. (John M.), Akhi, R. (Ramin), Buhlin, K. (Kåre), Johansson, A. (Anders), Paju, S. (Susanna), Salminen, A. (Aino), Mäntylä, P. (Päivi), Sinisalo, J. (Juha), Tjäderhane, L. (Leo), Hörkkö, S. (Sohvi), and Pussinen, P. J. (Pirkko J.)
- Abstract
Apical periodontitis is an inflammatory reaction at the apex of an infected tooth. Its microbiota resembles that of marginal periodontitis and may induce local and systemic antibodies binding to bacteria- and host-derived epitopes. Our aim was to investigate the features of the adaptive immune response in apical periodontitis. The present Parogene cohort (n = 453) comprises patients with cardiac symptoms. Clinical and radiographic oral examination was performed to diagnose apical and marginal periodontitis. A three-category endodontic lesion score was designed. Antibodies binding to the bacteria- and host-derived epitopes were determined from saliva and serum, and bacterial compositions were examined from saliva and subgingival samples. The significant ORs (95% CI) for the highest endodontic scores were observed for saliva IgA and IgG to bacterial antigens (2.90 (1.01–8.33) and 4.91 (2.48–9.71)/log10 unit), saliva cross-reacting IgG (2.10 (1.48–2.97)), serum IgG to bacterial antigens (4.66 (1.22–10.1)), and Gram-negative subgingival species (1.98 (1.16–3.37)). In a subgroup without marginal periodontitis, only saliva IgG against bacterial antigens associated with untreated apical periodontitis (4.77 (1.05–21.7)). Apical periodontitis associates with versatile adaptive immune responses against both bacterial- and host-derived epitopes independently of marginal periodontitis. Saliva immunoglobulins could be useful biomarkers of oral infections including apical periodontitis—a putative risk factor for systemic diseases.
- Published
- 2019
27. Association between dental factors and mortality.
- Author
-
Liljestrand, J. M., Salminen, A., Lahdentausta, L., Paju, S., Mäntylä, P., Buhlin, K., Tjäderhane, L., Sinisalo, J., and Pussinen, P. J.
- Subjects
COMORBIDITY ,DEATH rate ,ENDODONTICS ,DENTURES ,ROOT canal treatment ,CORONARY angiography - Abstract
Aim: To study whether oral parameters such as endodontic infections, root canal fillings, number of teeth or wearing removable dentures at baseline are associated with cardiovascular‐ and all‐cause mortality in a follow‐up of approximately 8 years. Methodology: The Finnish Parogene cohort consists of 508 Finnish adults (mean age 63.3 years, SD 9.1) with cardiac symptoms, all of whom had undergone coronary angiography for accurate baseline coronary status. Extensive clinical and radiographic oral examinations were performed, and additional data were acquired from medical records and questionnaires. Root canal fillings and endodontic lesions, as well as their co‐occurrence, were determined from panoramic radiographs. The mortality data were assessed via record linkage with the Finnish Causes of Death register (mean follow‐up time 7.81 years, SD 1.45 years). A total of n = 471 dentate patients were included in the statistical analyses. Results: A total of n = 69 deaths were recorded, of which n = 41 were due to cardiovascular diseases (CVDs, ICD‐10 I00–I99). The deceased had fewer root canal fillings (mean 1.57; SD 1.64 vs. mean 2.30; SD 2.34, P = 0.03) than the survivors. The number of missing teeth was associated with smoking, occluded coronary arteries and diabetes. Cox regression with Firth's penalized maximum‐likelihood method using age as timescale revealed an inverse association (HR; 95%CI) between mortality and number of teeth (all‐cause 0.91; 0.86–0.96, CVD mortality 0.89; 0.83–0.96), use of removable dentures (all‐cause 0.24; 0.09–0.62, CVD mortality 0.20; 0.06–0.72), root canal fillings (all‐cause 0.82; 0.70–0.94, CVD mortality 0.79; 0.63–0.96) and having root canal fillings in all teeth with apical rarefactions (all‐cause 0.27; 0.06–0.79, CVD mortality 0.09; 0.01–0.63), when gender, smoking, occluded coronary arteries, periodontal inflammatory burden index and the number of teeth were adjusted for. Conclusions: The number of missing teeth appeared to be the strongest predictor of mortality in this study, whereas endodontic infections per se had no independent association. Nevertheless, signs of professional intervention in these problems, such as root canal fillings and removable dentures, appeared to be associated with improved survival, which might partly be explained by the utilization of healthcare services. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
28. Cross-reactive saliva IgA antibodies to oxidized LDL and periodontal pathogens in humans
- Author
-
Akhi, R. (Ramin), Wang, C. (Chunguang), Kyrklund, M. (Mikael), Kummu, O. (Outi), Turunen, S. P. (S Pauliina), Hyvärinen, K. (Kati), Kullaa, A. (Arja), Salo, T. (Tuula), Pussinen, P. J. (Pirkko J.), and Hörkkö, S. (Sohvi)
- Subjects
stomatognathic system ,lipids (amino acids, peptides, and proteins) - Abstract
Aim: Oxidized low-density lipoproteins (oxLDL) are formed as a result of lipid peroxidation and are highly immunogenic and proatherogenic. In this study, saliva antibodies binding to oxLDL, Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) were characterized and their cross-reactivity was evaluated. Materials and Methods: Resting and stimulated saliva samples were collected from 36 healthy adults (mean age 26 years). Saliva IgA, IgG and IgM autoantibody levels to copper oxidized LDL (CuOx-LDL) and malondialdehyde acetaldehyde-modified LDL (MAA-LDL) were determined with chemiluminescence immunoassay. Results: Saliva IgA and IgG antibodies binding to MAA-LDL and CuOx-LDL were detected in all samples and they were associated with the saliva levels of IgA and IgG to P. gingivalis and A. actinomycetemcomitans. Competitive immunoassay showed that saliva antibodies to MAA-LDL cross-reacted specifically with P. gingivalis. The autoantibody levels to oxLDL in saliva were not associated with the autoantibody levels to oxLDL in plasma or with saliva apolipoprotein B 100 levels. Conclusions: Saliva contains IgA and IgG binding to oxLDL, which showed cross-reactive properties with the periodontal pathogens Porphyromonas gingivalis (P.g). The data suggest that secretory IgA to P.g may participate in immune reactions involved in LDL oxidation through molecular mimicry.
- Published
- 2017
29. Intestinal alkaline phosphatase at the crossroad of intestinal health and disease:a putative role in type 1 diabetes
- Author
-
Lassenius, M. I. (M. I.), Fogarty, C. L. (C. L.), Blaut, M. (M.), Haimila, K. (K.), Riittinen, L. (L.), Paju, A. (A.), Kirveskari, J. (J.), Järvelä, J. (J.), Ahola, A. J. (A. J.), Gordin, D. (D.), Härma, M. (M.‐A.), Kumar, A. (A.), Hamarneh, S. R. (S. R.), Hodin, R. A. (R. A.), Sorsa, T. (T.), Tervahartiala, T. (T.), Hörkkö, S. (S.), Pussinen, P. J. (P. J.), Forsblom, C. (C.), Jauhiainen, M. (M.), Taskinen, M. (M.‐R.), Groop, P. (P.‐H.), Lehto, M. (M.), Lassenius, M. I. (M. I.), Fogarty, C. L. (C. L.), Blaut, M. (M.), Haimila, K. (K.), Riittinen, L. (L.), Paju, A. (A.), Kirveskari, J. (J.), Järvelä, J. (J.), Ahola, A. J. (A. J.), Gordin, D. (D.), Härma, M. (M.‐A.), Kumar, A. (A.), Hamarneh, S. R. (S. R.), Hodin, R. A. (R. A.), Sorsa, T. (T.), Tervahartiala, T. (T.), Hörkkö, S. (S.), Pussinen, P. J. (P. J.), Forsblom, C. (C.), Jauhiainen, M. (M.), Taskinen, M. (M.‐R.), Groop, P. (P.‐H.), and Lehto, M. (M.)
- Abstract
Background: Patients with type 1 diabetes have shown an increase in circulating cytokines, altered lipoprotein metabolism and signs of vascular dysfunction in response to high‐fat meals. Intestinal alkaline phosphatase (IAP) regulates lipid transport and inflammatory responses in the gastrointestinal tract. We therefore hypothesized that changes in IAP activity could have profound effects on gut metabolic homeostasis in patients with type 1 diabetes. Methods: Faecal samples of 41 nondiabetic controls and 46 patients with type 1 diabetes were analysed for IAP activity, calprotectin, immunoglobulins and short‐chain fatty acids (SCFAs). The impact of oral IAP supplementation on intestinal immunoglobulin levels was evaluated in C57BL/6 mice exposed to high‐fat diet for 11 weeks. Results: Patients with type 1 diabetes exhibited signs of intestinal inflammation. Compared to controls, patients with diabetes had higher faecal calprotectin levels, lower faecal IAP activities accompanied by lower propionate and butyrate concentrations. Moreover, the amount of faecal IgA and the level of antibodies binding to oxidized LDL were decreased in patients with type 1 diabetes. In mice, oral IAP supplementation increased intestinal IgA levels markedly. Conclusion: Deprivation of protective intestinal factors may increase the risk of inflammation in the gut — a phenomenon that seems to be present already in patients with uncomplicated type 1 diabetes. Low levels of intestinal IgA and antibodies to oxidized lipid epitopes may predispose such patients to inflammation‐driven complications such as cardiovascular disease and diabetic nephropathy. Importantly, oral IAP supplementation could have beneficial therapeutic effects on gut metabolic homeostasis, possibly through stimulation of intestinal IgA secretion.
- Published
- 2017
30. Endotoxemia is associated with an adverse metabolic profile
- Author
-
Määttä, Anne-Mari, Salminen, Aino, Pietiäinen, Milla, Leskelä, Jaakko, Palviainen, Teemu, Sattler, Wolfgang, Sinisalo, Juha, Salomaa, Veikko, Kaprio, Jaakko, and Pussinen, Pirkko J
- Abstract
Our aim was to analyze whether endotoxemia, i.e. translocation of LPS to circulation, is reflected in the serum metabolic profile in a general population and in participants with cardiometabolic disorders. We investigated three Finnish cohorts separately and in a meta-analysis (n= 7178), namely population-based FINRISK97, FinnTwin16 consisting of young adult twins, and Parogene, a random cohort of cardiac patients. Endotoxemia was determined as serum LPS activity and metabolome by an NMR platform. Potential effects of body mass index (BMI), smoking, metabolic syndrome (MetS), and coronary heart disease (CHD) status were considered. Endotoxemia was directly associated with concentrations of VLDL, IDL, LDL, and small HDL lipoproteins, VLDL particle diameter, total fatty acids (FA), glycoprotein acetyls (GlycA), aromatic and branched-chain amino acids, and Glc, and inversely associated with concentration of large HDL, diameters of LDL and HDL, as well as unsaturation degree of FAs. Some of these disadvantageous associations were significantly stronger in smokers and subjects with high BMI, but did not differ between participants with different CHD status. In participants with MetS, however, the associations of endotoxemia with FA parameters and GlycA were particularly strong. The metabolic profile in endotoxemia appears highly adverse, involving several inflammatory characters and risk factors for cardiometabolic disorders.
- Published
- 2021
- Full Text
- View/download PDF
31. Smoking confounds the periodontal diagnostics using saliva biomarkers.
- Author
-
Lahdentausta, Laura, Paju, Susanna, Mäntylä, Päivi, Buhlin, Kåre, Pietiäinen, Milla, Tervahartiala, Taina, Nieminen, Markku S., Sinisalo, Juha, Sorsa, Timo, and Pussinen, Pirkko J.
- Abstract
Background: Smoking is a risk factor for periodontal disease because of its complex impact on the inflammatory response in the periodontium. We investigated the effect of smoking on salivary periodontal biomarkers, matrix metalloproteinase (MMP)-8, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and myeloperoxidase (MPO).Methods: Saliva biomarkers were analyzed in the Parogene population (n = 480) comprising a random cohort of patients that have undergone coronary angiography and oral examination. The effect of time since cessation and pack years of smoking on biomarkers were investigated.Results: Saliva MMP-8, MMP-9, TIMP-1, and MPO concentrations distinguished periodontitis patients significantly from patients without periodontitis. When the time since cessation was considered, the area-under-the-curve values (p-value) for periodontitis were 0.76 (<0.001), 0.74 (<0.001), 0.70 (<0.001), and 0.76 (<0.001), respectively. Adding information about smoking habits in the models improved slightly the sensitivities of all biomarkers. In logistic regression model saliva, MMP-8 was mainly affected by pack years of smoking, whereas saliva MMP-9, TIMP-1, and MPO were mostly affected by time since cessation, especially if smoking currently or quit recently (<1 year ago).Conclusion: Smoking confounds the salivary diagnostics of periodontitis and should be considered when interpreting the results obtained by potential diagnostic tests. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
32. Salivary IgA to MAA-LDL and Oral Pathogens Are Linked to Coronary Disease.
- Author
-
Akhi, R., Wang, C., Nissinen, A. E., Kankaanpää, J., Bloigu, R., Paju, S., Mäntylä, P., Buhlin, K., Sinisalo, J., Pussinen, P. J., and Hörkkö, S.
- Subjects
IMMUNOGLOBULIN A ,SALIVA ,CORONARY heart disease risk factors ,LOW density lipoproteins ,MALONDIALDEHYDE ,PORPHYROMONAS gingivalis ,ACTINOBACILLUS actinomycetemcomitans ,COMPARATIVE studies ,CORONARY disease ,GRAM-negative bacteria ,IMMUNOGLOBULINS ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,EVALUATION research ,GRAM-negative anaerobic bacteria - Abstract
A large body of literature has established the link between periodontal disease and cardiovascular disease. Oxidized low-density lipoproteins (OxLDLs) have a crucial role in atherosclerosis progression through initiation of immunological response. Monoclonal IgM antibodies to malondialdehyde-modified low-density lipoprotein (MDA-LDL) and to malondialdehyde acetaldehyde-modified low-density lipoprotein (MAA-LDL) have been shown to cross-react with the key virulence factors of periodontal pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. We have previously shown that salivary IgA antibodies to MAA-LDL cross-react with P. gingivalis in healthy humans. In this study, we aim to assess whether oral mucosal immune response represented by salivary IgA to MAA-LDL and oral pathogens is associated with coronary artery disease (CAD). Also, the molecular mimicry through antibody cross-reaction between salivary IgA to MAA-LDL and oral pathogens was evaluated. The study subjects consisted of 451 patients who underwent a coronary angiography with no CAD ( n = 133), stable CAD ( n = 169), and acute coronary syndrome (ACS, n = 149). Elevated salivary IgA antibody levels to MAA-LDL, Rgp44 (gingipain A hemagglutinin domain of P. gingivalis), and Aa-HSP60 (heat shock protein 60 of A. actinomycetemcomitans) were discovered in stable-CAD and ACS patients when compared to no-CAD patients. In a multinomial regression model adjusted for known cardiovascular risk factors, stable CAD and ACS were associated with IgA to MAA-LDL ( P = 0.016, P = 0.043), Rgp44 ( P = 0.012, P = 0.004), Aa-HSP60 ( P = 0.032, P = 0.030), Tannerella forsythia ( P = 0.002, P = 0.004), Porphyromonas endodontalis ( P = 0.016, P = 0.020), Prevotella intermedia ( P = 0.038, P = 0.005), and with total IgA antibody concentration ( P = 0.002, P = 0.016). Salivary IgA to MAA-LDL showed cross-reactivity with the oral pathogens tested in the study patients. The study highlights an association between salivary IgA to MAA-LDL and atherosclerosis. However, whether salivary IgA to MAA-LDL and the related oral humoral responses play a causal role in the development in the CAD should be elucidated in the future. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
33. Mannose-binding lectin gene polymorphism in relation to periodontal infection
- Author
-
Liukkonen, A., primary, He, Q., additional, Gürsoy, U. K., additional, Pussinen, P. J., additional, Gröndahl-Yli-Hannuksela, K., additional, Liukkonen, J., additional, Sorsa, T., additional, Suominen, A. L., additional, Huumonen, S., additional, and Könönen, E., additional
- Published
- 2016
- Full Text
- View/download PDF
34. Genetic Variants Contributing to Circulating Matrix Metalloproteinase 8 Levels and Their Association With Cardiovascular Diseases: A Genome-Wide Analysis.
- Author
-
Salminen, Aino, Vlachopoulou, Efthymia, Havulinna, Aki S., Tervahartiala, Taina, Sattler, Wolfgang, Lokki, Marja-Liisa, Nieminen, Markku S., Perola, Markus, Salomaa, Veikko, Sinisalo, Juha, Meri, Seppo, Sorsa, Timo, and Pussinen, Pirkko J.
- Abstract
Background--Matrix metalloproteinase 8 (MMP-8) is a proinflammatory enzyme expressed mainly by neutrophils. Elevated serum and plasma concentrations of MMP-8 are associated with the risk for and outcome of cardiovascular diseases (CVDs). The origin of circulating MMP-8 is not completely clear. Methods and Results--We performed a genome-wide association study of serum MMP-8 levels in 2 populations comprising altogether 6049 individuals. Moreover, we studied whether MMP-8-associated variants are linked to increased risk of CVDs and overall mortality in >20 000 subjects. The strongest association with serum MMP-8 was found in locus 1q31.3, containing the gene for complement factor H (lead single nucleotide polymorphism: rs800292; P=2.4×10
-35 ). In functional experiments, activation of the alternative pathway of complement in the carriers of rs800292 minor allele (Ile62 in factor H) led to decreased release of MMP-8 from neutrophils compared with the major allele (Val62 in factor H). Another association was detected in 1q21.3, containing genes S100A8, S100A9, and S100A12 (strongest association: rs1560833; P=5.3×10-15 ). The minor allele of rs1560833 was inversely associated with CVD (odds ratio [95% confidence interval]: 0.90 [0.82-0.99]; P=0.032) and the time to incident CVD event (hazard ratio [95% confidence interval]: 0.91 [0.84-0.99]; P=0.032) in men but not in women. Conclusions--According to our results, the activation of the alternative pathway of the complement system strongly contributes to serum MMP-8 concentration. Genetic polymorphism in S100A9-S100A12-S100A8 locus affects serum and plasma MMP-8 and shows a suggestive association with the risk of CVDs. Our results show that genetic variation determines a significant portion of circulating MMP-8 concentrations. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
35. Acute myocardial infarction elevates serine protease activity in saliva of patients with periodontitis
- Author
-
Sorsa, T., Baris, N., Pussinen, P. J., Tervahartiala, T., Emingil, G., Buduneli, E., Mantyla, P., ATİLLA, FATMA GÜL, and Akilli, A.
- Abstract
Background and Objective: There are indications that acute myocardial infarction (AMI) may have an effect on the oral environment, which is reflected in the expression of salivary and gingival proteinases. According to our knowledge, no studies have been carried out to investigate the effect of AMI on the activities of two major tissue-destructive serine protease and microbial effectors, elastase and cathepsin G, produced by oral fluid polymorphonuclear granulocytes (PMN). Therefore, we compared the activities of elastase and cathepsin G in saliva from patients with AMI and from systemically healthy subjects (non-AMI) with similar periodontal conditions. Material and Methods: A total of 92 patients (47 AMI and 28 non-AMI patients with gingivitis or periodontitis, and 17 systemically and periodontally healthy subjects as a control group) were recruited. Clinical periodontal measurements were recorded, and stimulated whole-saliva samples were collected. The patients with AMI were clinically examined within 3-4 d after admission to the coronary care unit. The activities of saliva neutrophil elastase and cathepsin G were measured after collection, at specific time-points during incubation (from baseline to 23 h) by specific synthetic peptide substrate assays. Results: The saliva of patients with AMI and periodontitis had a significant trend for the highest elastase activities among the study groups. Elastase and cathepsin G activities correlated significantly with each other in the AMI periodontitis group (r = 0.8, p < 0.01). In a logistic regression analysis, the level of salivary elastase activity associated significantly with periodontitis. Conclusion: AMI may be reflected in PMN serine protease elastase activity in saliva, despite its strong association with periodontitis.
- Published
- 2012
36. Intestinal alkaline phosphatase at the crossroad of intestinal health and disease - a putative role in type 1 diabetes.
- Author
-
Lassenius, M. I., Fogarty, C. L., Blaut, M., Haimila, K., Riittinen, L., Paju, A., Kirveskari, J., Järvelä, J., Ahola, A. J., Gordin, D., Härma, M.‐A., Kumar, A., Hamarneh, S. R., Hodin, R. A., Sorsa, T., Tervahartiala, T., Hörkkö, S., Pussinen, P. J., Forsblom, C., and Jauhiainen, M.
- Subjects
IMMUNOGLOBULIN A ,TYPE 1 diabetes ,INFLAMMATION ,ALKALINE phosphatase ,SHORT-chain fatty acids - Abstract
Background: Patients with type 1 diabetes have shown an increase in circulating cytokines, altered lipoprotein metabolism and signs of vascular dysfunction in response to high-fat meals. Intestinal alkaline phosphatase (IAP) regulates lipid transport and inflammatory responses in the gastrointestinal tract. We therefore hypothesized that changes in IAP activity could have profound effects on gut metabolic homeostasis in patients with type 1 diabetes.Methods: Faecal samples of 41 nondiabetic controls and 46 patients with type 1 diabetes were analysed for IAP activity, calprotectin, immunoglobulins and short-chain fatty acids (SCFAs). The impact of oral IAP supplementation on intestinal immunoglobulin levels was evaluated in C57BL/6 mice exposed to high-fat diet for 11 weeks.Results: Patients with type 1 diabetes exhibited signs of intestinal inflammation. Compared to controls, patients with diabetes had higher faecal calprotectin levels, lower faecal IAP activities accompanied by lower propionate and butyrate concentrations. Moreover, the amount of faecal IgA and the level of antibodies binding to oxidized LDL were decreased in patients with type 1 diabetes. In mice, oral IAP supplementation increased intestinal IgA levels markedly.Conclusion: Deprivation of protective intestinal factors may increase the risk of inflammation in the gut - a phenomenon that seems to be present already in patients with uncomplicated type 1 diabetes. Low levels of intestinal IgA and antibodies to oxidized lipid epitopes may predispose such patients to inflammation-driven complications such as cardiovascular disease and diabetic nephropathy. Importantly, oral IAP supplementation could have beneficial therapeutic effects on gut metabolic homeostasis, possibly through stimulation of intestinal IgA secretion. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
37. Systemic Aggregatibacter actinomycetemcomitans Leukotoxin-Neutralizing Antibodies in Periodontitis.
- Author
-
Johansson, Anders, Buhlin, Kåre, Sorsa, Timo, Pussinen, Pirkko J., and Buhlin, Kåre
- Abstract
Background: Leukotoxin (Ltx) expressed by Aggregatibacter actinomycetemcomitans is a powerful exotoxin, which can cause imbalance in host response. Immunoreactivity to Ltx is a marker for presence of leukotoxic A. actinomycetemcomitans, a presence that may modify the disease pattern of colonized individuals. The aim of the present study is to examine presence of systemic immunoreactivity to A. actionmycetemcomitans Ltx with respect to clinical and inflammatory findings in individuals with or without periodontitis (N = 88).Methods: Periodontal status was examined in patients with severe periodontitis (n = 49) and healthy controls (n = 39), and patients received periodontal treatment. Systemic biomarkers associated with inflammation and infections as well as clinical parameters were analyzed at baseline and 3 and 6 months after treatment.Results: Presence of immunoreactivity against Ltx was associated with impaired remission of disease after periodontal treatment. This immunoreactivity was also significantly associated with increased systemic levels of A. actinomycetemcomitans-specific immunoglobulins and increasing age.Conclusion: Presence and levels of systemic immunoreactivity against A. actinomycetemcomitans Ltx are associated with decreased remission after otherwise successful periodontal treatment. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
38. Salivary Concentrations of Interleukin (IL)-1β, IL-17A, and IL-23 Vary in Relation to Periodontal Status.
- Author
-
Liukkonen, Joonas, Gürsoy, Ulvi K., Pussinen, Pirkko J., Suominen, Anna L., Könönen, Eija, Gürsoy, Ulvi K, and Könönen, Eija
- Abstract
Background: Interleukin (IL)-23-induced T helper (Th) 17 pathway is involved in the pathogenesis of periodontal disease. This study's aim is to determine levels of IL-1β, IL-17A, IL-23, and lipopolysaccharide (LPS) in saliva, and to examine whether their salivary concentrations are associated with periodontal health status.Methods: Saliva samples originated from 220 participants; 76 had generalized periodontitis (GP) and 65 had localized periodontitis (LP), whereas 79 without periodontitis were used as controls. Cytokine analyses were performed by a flow cytometry-based technique and LPS analyses from pellet by commercially optimized assay coupled with chromogenic substrate.Results: Salivary concentrations of IL-17A and IL-23 were elevated significantly in patients with LP compared with controls and patients with GP. Salivary IL-1β concentrations were significantly higher in patients with GP than in patients with LP, whereas no difference was found between LP and control groups. Significant correlation was found between concentrations of IL-17A and IL-23 or IL-1β. LPS concentrations did not have significant associations with any of the tested ILs.Conclusion: Elevated salivary IL-1β concentrations are related to GP, whereas distinct elevation and reduction profiles of IL-17A and IL-23 are detected in saliva of patients with LP and GP. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
39. Association of Endodontic Lesions with Coronary Artery Disease.
- Author
-
Liljestrand, J. M., Mäntylä, P., Paju, S., Buhlin, K., Kopra, K. A. E., Persson, G. R., Hernandez, M., Nieminen, M. S., Sinisalo, J., Tjäderhane, L., and Pussinen, P. J.
- Subjects
ENDODONTICS ,CORONARY disease ,PORPHYROMONAS ,CROSS-sectional method ,IMMUNE response ,LIPOPOLYSACCHARIDES ,CORONARY angiography ,DNA - Abstract
An endodontic lesion (EL) is a common manifestation of endodontic infection where Porphyromonas endodontalis is frequently encountered. EL may associate with increased risk for coronary artery disease (CAD) via similar pathways as marginal periodontitis. The aim of this cross-sectional study was to delineate the associations between EL and CAD. Subgingival P. endodontalis, its immune response, and serum lipopolysaccharide were examined as potential mediators between these 2 diseases. The Finnish Parogene study consists of 508 patients (mean age, 62 y) who underwent coronary angiography and extensive clinical and radiographic oral examination. The cardiovascular outcomes included no significant CAD ( n = 123), stable CAD ( n = 184), and acute coronary syndrome (ACS; n = 169). EL was determined from a panoramic tomography. We combined data of widened periapical spaces (WPSs) and apical rarefactions to a score of EL: 1, no EL ( n = 210); 2, ≥1 WPS per 1 apical rarefaction ( n = 222); 3, ≥2 apical rarefactions ( n = 76). Subgingival P. endodontalis was defined by checkerboard DNA-DNA hybridization analysis, and corresponding serum antibodies were determined by ELISA. In our population, 50.4% had WPSs, and 22.8% apical rarefactions. A total of 51.2% of all teeth with apical rarefactions had received endodontic procedures. Subgingival P. endodontalis levels and serum immunoglobulin G were associated with a higher EL score. In the multiadjusted model (age, sex, smoking, diabetes, body mass index, alveolar bone loss, and number of teeth), having WPSs associated with stable CAD (odds ratio [OR] = 1.94, 95% confidence interval [95% CI] = 1.13 to 3.32, P = 0.016) and highest EL score were associated with ACS (OR = 2.46, 95% CI = 1.09 to 5.54, P = 0.030). This association was especially notable in subjects with untreated teeth with apical rarefactions ( n = 59, OR = 2.72, 95% CI = 1.16 to 6.40, P = 0.022). Our findings support the hypothesis that ELs are independently associated with CAD and in particular with ACS. This is of high interest from a public health perspective, considering the high prevalence of ELs and CAD. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
40. Systemic exposure to a common periodontal pathogen and missing teeth are associated with metabolic syndrome
- Author
-
Hyvärinen, K., primary, Salminen, A., additional, Salomaa, V., additional, and Pussinen, P. J., additional
- Published
- 2014
- Full Text
- View/download PDF
41. Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype
- Author
-
Liukkonen, Joonas, Gürsoy, Ulvi K, Könönen, Eija, Gürsoy, Mervi, Metso, Jari, Salminen, Aino, Kopra, Elisa, Jauhiainen, Matti, Mäntylä, Päivi, Buhlin, Kåre, Paju, Susanna, Sorsa, Timo, Nieminen, Markku S, Lokki, Marja-Liisa, Sinisalo, Juha, and Pussinen, Pirkko J
- Abstract
Genetic factors play a role in periodontitis. Here we examined whether the risk haplotype of MHC class III region BAT1-NFKBIL1-LTA and lymphotoxin-α polymorphisms associate with salivary biomarkers of periodontal disease. A total of 455 individuals with detailed clinical and radiographic periodontal health data were included in the study. A 610 K genotyping chip and a Sequenom platform were used in genotyping analyses. Phospholipid transfer protein activity, concentrations of lymphotoxin-α, IL-8 and myeloperoxidase, and a cumulative risk score (combining Porphyromonas gingivalis, IL-1β and matrix metalloproteinase-8) were examined in saliva samples. Elevated IL-8 and myeloperoxidase concentrations and cumulative risk scores associated with advanced tooth loss, deepened periodontal pockets and signs of periodontal inflammation. In multiple logistic regression models adjusted for periodontal parameters and risk factors, myeloperoxidase concentration (odds ratio (OR); 1.37, P= 0.007) associated with increased odds for having the risk haplotype and lymphotoxin-α concentration with its genetic variants rs2857708, rs2009658 and rs2844482. In conclusion, salivary levels of IL-8, myeloperoxidase and cumulative risk scores associate with periodontal inflammation and tissue destruction, while those of myeloperoxidase and lymphotoxin-α associate with genetic factors as well.
- Published
- 2018
- Full Text
- View/download PDF
42. Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients with coronary artery disease.
- Author
-
Palikhe, A, Lokki, M-L, Pussinen, P J, Paju, S, Ahlberg, J, Asikainen, S, Seppänen, M, Valtonen, V, Nieminen, M S, Sinisalo, J, Palikhe, A, Lokki, M-L, Pussinen, P J, Paju, S, Ahlberg, J, Asikainen, S, Seppänen, M, Valtonen, V, Nieminen, M S, and Sinisalo, J
- Abstract
Periodontitis and coronary artery disease (CAD) are inflammatory diseases and associated with each other. The major histocompatibility complex (MHC) region carries genes involved in immune response and inflammation. We investigated whether the MHC genes correlate with the presence of periodontitis or with the occurrence of periodontal pathogens in patients with CAD. Blood and saliva samples from CAD patients (n = 106) were collected at the time of hospitalization. Nine MHC genetic markers [human leukocyte antigen (HLA)-A, HLA-B, HLA-DRB1, lymphotoxin alpha (LTA) +253(a/g), +496(C/T), +633(c/g), +724(C/A), C4A and C4B)] were typed. Based on panoramic tomography, patients were categorized into nonperiodontitis and periodontitis groups. Two major periodontal pathogens, Aggregatibacter (Actinobacillus) actinomycetemcomitans and Porphyromonas gingivalis, were cultivated and polymerase chain reaction-amplified from salivary samples. Serum immunoglobulin (Ig)A and IgG antibody levels to these pathogens were measured. In the univariate analysis, LTA+496C allele (OR = 5.29; 95% CI = 2.07-13.51, P = 0.00027), and the occurrence of P. gingivalis in saliva (OR = 4.74; 95% CI = 1.64-13.70; P = 0.002) were more frequent in periodontitis when compared with nonperiodontitis. Similarly, serum IgA antibody level against the pathogen was increased in periodontitis (P = 0.048). In the multiple logistic regression analysis, when a wide range of covariates was included, the LTA+496C allele (OR = 10.87; 95% CI = 3.23-36.60; P = 0.00012) and the elevated serum IgA antibody level against P. gingivalis (OR = 1.56; 95% CI = 1.05-2.30; P = 0.026) remained as significant risk factors for periodontitis. In conclusion, the major finding of this study is that the LTA+496C allele is associated with periodontitis in patients with CAD.
- Published
- 2008
- Full Text
- View/download PDF
43. Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort
- Author
-
Kormi, Immi, Nieminen, Mikko T, Havulinna, Aki S, Zeller, Tanja, Blankenberg, Stefan, Tervahartiala, Taina, Sorsa, Timo, Salomaa, Veikko, and Pussinen, Pirkko J
- Abstract
Background Extracellular matrix degrading proteases and their regulators play an important role in atherogenesis and subsequent plaque rupture leading to acute cardiovascular manifestations.Design and methods In this prospective cohort study, we investigated the prognostic value of circulating matrix metalloproteinase-8, tissue inhibitor of matrix metalloproteinase-1 concentrations, the ratio of matrix metalloproteinase-8/ tissue inhibitor of matrix metalloproteinase-1 and, for comparison, myeloperoxidase and C-reactive protein concentrations for incident cardiovascular disease endpoints. The population-based FINRISK97 cohort comprised 7928 persons without cardiovascular disease at baseline. The baseline survey included a clinical examination and blood sampling. During a 13-year follow-up the endpoints were ascertained through national healthcare registers. The associations of measured biomarkers with the endpoints, including cardiovascular disease event, coronary artery disease, acute myocardial infarction, stroke and all-cause death, were analysed using Cox regression models. Discrimination and reclassification models were used to evaluate the clinical implications of the biomarkers.Results Serum tissue inhibitor of matrix metalloproteinase-1 and C-reactive protein concentrations were associated significantly with increased risk for all studied endpoints. Additionally, matrix metalloproteinase-8 concentration was associated with the risk for a coronary artery disease event, myocardial infarction and death, and myeloperoxidase concentration with the risk for cardiovascular disease events, stroke and death. The only significant association for the matrix metalloproteinase-8/ tissue inhibitor of matrix metalloproteinase-1 ratio was observed with the risk for myocardial infarction. Adding tissue inhibitor of matrix metalloproteinase-1 to the established risk profile improved risk discrimination of myocardial infarction (p=0.039) and death (0.001). Both matrix metalloproteinase-8 (5.2%, p< 0.001) and tissue inhibitor of matrix metalloproteinase-1 (12.9%, p< 0.001) provided significant clinical net reclassification improvement for death.Conclusions Serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 can be considered as biomarkers of incident cardiovascular disease events and death.
- Published
- 2017
- Full Text
- View/download PDF
44. Systemic Aggregatibacter actinomycetemcomitansLeukotoxin‐Neutralizing Antibodies in Periodontitis
- Author
-
Johansson, Anders, Buhlin, Kåre, Sorsa, Timo, and Pussinen, Pirkko J.
- Abstract
Background:Leukotoxin (Ltx) expressed by Aggregatibacter actinomycetemcomitansis a powerful exotoxin, which can cause imbalance in host response. Immunoreactivity to Ltx is a marker for presence of leukotoxic A. actinomycetemcomitans, a presence that may modify the disease pattern of colonized individuals. The aim of the present study is to examine presence of systemic immunoreactivity to A. actionmycetemcomitansLtx with respect to clinical and inflammatory findings in individuals with or without periodontitis (N = 88). Methods:Periodontal status was examined in patients with severe periodontitis (n = 49) and healthy controls (n = 39), and patients received periodontal treatment. Systemic biomarkers associated with inflammation and infections as well as clinical parameters were analyzed at baseline and 3 and 6 months after treatment. Results:Presence of immunoreactivity against Ltx was associated with impaired remission of disease after periodontal treatment. This immunoreactivity was also significantly associated with increased systemic levels of A. actinomycetemcomitans‐specific immunoglobulins and increasing age. Conclusion:Presence and levels of systemic immunoreactivity against A. actinomycetemcomitansLtx are associated with decreased remission after otherwise successful periodontal treatment.
- Published
- 2017
- Full Text
- View/download PDF
45. Acute myocardial infarction elevates serine protease activity in saliva of patients with periodontitis
- Author
-
Mäntylä, P., primary, Buduneli, E., additional, Emingil, G., additional, Tervahartiala, T., additional, Pussinen, P. J., additional, Barış, N., additional, Akıllı, A., additional, Atilla, G., additional, and Sorsa, T., additional
- Published
- 2011
- Full Text
- View/download PDF
46. Oral health: a neglected aspect of diabetes care
- Author
-
Pussinen, Pirkko J and Salomaa, Veikko
- Published
- 2018
- Full Text
- View/download PDF
47. Missing Teeth Predict Incident Cardiovascular Events, Diabetes, and Death.
- Author
-
Liljestrand, J M, Havulinna, A S, Paju, S, Männistö, S, Salomaa, V, and Pussinen, P J
- Published
- 2015
- Full Text
- View/download PDF
48. High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction
- Author
-
Pussinen, P. J., primary, Alfthan, G., additional, Tuomilehto, J., additional, Asikainen, S., additional, and Jousilahti, P., additional
- Published
- 2004
- Full Text
- View/download PDF
49. Multiserotype Enzyme-Linked Immunosorbent Assay as a Diagnostic Aid for Periodontitis in Large-Scale Studies
- Author
-
Pussinen, P. J., primary, Vilkuna-Rautiainen, T., additional, Alfthan, G., additional, Mattila, K., additional, and Asikainen, S., additional
- Published
- 2002
- Full Text
- View/download PDF
50. Oral health: A modifiable risk factor for cardiovascular diseases or a confounded association?
- Author
-
Pussinen, Pirkko J and Könönen, Eija
- Published
- 2016
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.