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238 results on '"Pushpam, Deepam"'

6. Prognostic relevance of surface expression of cytokine receptor-like factor 2 in pediatric B-lineage acute lymphoblastic leukemia.

Author

Singh, Jay, Benjamin, Mercilena, Pandey, Avanish, Kumari, Sarita, Ali, Mohammad, Palanichamy, Jayanth, Bakhshi, Sameer, Singh, Amitabh, Pushpam, Deepam, Kumar, Akash, Seth, Rachna, Singh, Inder, Tanwar, Pranay, Singh, Amar, Arora, Mohit, Chopra, Anita, and Sharma, Gunjan

Subjects
B-ALL, CRLF2, Leukemia, copy number alterations, pediatric malignancies, prognosis
Abstract

Overexpression of cytokine receptor-like factor 2 (CRLF2) resulting from its genomic rearrangement is the most frequent genetic alteration found in Philadelphia chromosome-like (Ph-like) B-cell acute lymphoblastic leukemia (B-ALL), a high-risk leukemia. Detection of CRLF2 expression by multiparameter flow cytometry has been proposed as a screening tool for the identification of Ph-like B-ALL. However, the prognostic relevance of flow cytometric expression of CRLF2 in pediatric B-ALL is not very clear. Additionally, its association with common copy number alterations (CNA) has not been studied in detail. Hence, in this study, we prospectively evaluated the flow cytometric expression of CRLF2 in 256 pediatric B-ALL patients and determined its association with molecular features such as common CNAs detected using Multiplex ligation-dependent probe amplification and mutations in CRLF2, JAK2 and IL7RA genes. Further, its association with clinicopathological features including patient outcome was assessed. We found that 8.59% (22/256) pediatric B-ALL patients were CRLF2-positive at diagnosis. Among CNAs, CRLF2 positivity was associated with presence of PAX5 alteration (P=0.041). JAK2 and IL-7R mutations were found in 9% and 13.6% CRLF2-positive patients, respectively. IGH::CRLF2 or P2RY8::CRLF2 fusions were each found in 1/22 individuals. CRLF2-positive patients were found to have inferior overall (hazard ratio (HR) =4.39, P=0.006) and event free survival (HR=2.62, P=0.045), independent to other clinical features. Furthermore, concomitant CNA of IKZF1 in CRLF2 positive patients was associated with a greater hazard for poor overall and event free survival, compared to patients without these alterations or presence of any one of them. Our findings demonstrate that the surface CRLF2 expression in association with IKZF1 copy number alteration can be used to risk stratify pediatric B-ALL patients.

Published
2023

15. Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease

Author

Mendiratta, Mohini, primary, Mendiratta, Meenakshi, additional, Ganguly, Shuvadeep Kumar, additional, Rai, Sandeep, additional, Gupta, Ritu, additional, Kumar, Lalit, additional, Bakhshi, Sameer, additional, Dadhwal, Vatsla, additional, Pushpam, Deepam, additional, Malik, Prabhat S, additional, Pramanik, Raja, additional, Aggarwal, Mukul, additional, Gupta, Aditya Kumar, additional, Dhawan, Rishi, additional, Seth, Tulika, additional, Mahapatra, Manoranjan, additional, Nayak, Baibaswata, additional, Singh, Thoudam Debraj, additional, Singla, Sachin Kumar, additional, Singh, Mayank, additional, Prasad, Chandra Prakash, additional, Prakash, Hridayesh, additional, Mohanty, Sujata, additional, and Sahoo, Ranjit Kumar, additional

Published
2024
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18. The impact of COVID-19 pandemic on access to treatment for children with cancer in India and treating centre practices: Results of the InPOG-ACC-20-04 study

Author

Sharma, Jyotsna, primary, mahajan, amita, additional, Bakhshi, Sameer, additional, Patil, Veerendra, additional, Verma, Nishant, additional, Radhakrishnan, Venkatraman, additional, Singh, Amitabh, additional, Kayal, Smita, additional, Seth, Rachna, additional, Pushpam, Deepam, additional, and Arora, Ramandeep, additional

Published
2024
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19. Treatment outcomes in patients with Ewing sarcoma of the spine in a resource-challenged setting: 17-year experience from a single center in India

Author

Sasi, Archana, primary, Chitikela, Sindhura, additional, Ganguly, Shuvadeep, additional, Biswas, Bivas, additional, Pushpam, Deepam, additional, Kumar, Akash, additional, Khan, Shah Alam, additional, Kumar, Venkatesan Sampath, additional, Kale, Shashank Sharad, additional, Biswas, Ahitagni, additional, Barwad, Adarsh, additional, Mridha, Asit Ranjan, additional, Thulkar, Sanjay, additional, and Bakhshi, Sameer, additional

Published
2024
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21. Autologous Stem Cell Transplantation in Adult Hodgkin Lymphoma at a Tertiary Care Center in India: Analysis of Outcomes and Prognostic Factors

Author

Kumar, Sudhir, primary, Sharma, Atul, additional, Bakhshi, Sameer, additional, Pushpam, Deepam, additional, Gogia, Ajay, additional, Sahoo, Ranjit Kumar, additional, Pramanik, Raja, additional, Kumar, Akash, additional, Pathak, Neha, additional, Thulkar, Sanjay, additional, Sharma, Meher Chand, additional, Gupta, Ritu, additional, Mallick, Soumya, additional, and Raina, Vinod, additional

Published
2023
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29. Response to comment on long‐term effects of chemotherapy and radiation received during early childhood on the developing dentition of pediatric cancer patients.

Author

Rahul, Morankar, Atif, Mohammad, Ganguly, Shuvadeep, Pushpam, Deepam, Sahni, Shubham, Tewari, Nitesh, Mathur, Vijay Prakash, and Bakhshi, Sameer

Subjects
CHILDHOOD cancer, CANCER patients, DENTITION, CANCER chemotherapy, INTENSITY modulated radiotherapy
Abstract

This article is a response to a letter received regarding a research paper titled "Long‐term effects of chemotherapy and radiation received during early childhood on the developing dentition of pediatric cancer patients." The research paper explores the impact of chemotherapy and radiation on the development of teeth in childhood cancer survivors. The letter raised concerns about the dose of radiation received by the jaw and dentition. The authors of the response address these concerns and provide additional information about the study's methodology and findings. They emphasize the need for more definitive information regarding the dose of radiation and chemotherapy received to understand their effects on dental development. [Extracted from the article]

Published
2024
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31. Formulation and validation of a baseline prognostic score for osteosarcoma treated uniformly with a non-high dose methotrexate-based protocol from a low middle income healthcare setting: a single centre analysis of 594 patients

Author

Ganguly, Shuvadeep, primary, Sasi, Archana, additional, Khan, Shah Alam, additional, Kumar, Venkatesan Sampath, additional, Kapoor, Love, additional, Sharma, Mehar Chand, additional, Mridha, Asit, additional, Barwad, Adarsh, additional, Thulkar, Sanjay, additional, Pushpam, Deepam, additional, and Bakhshi, Sameer, additional

Published
2023
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32. Dexamethasone-free antiemetic strategy for highly emetogenic chemotherapy: safety and efficacy-pilot study

Author

Sharma, Vinod, primary, Kumar, Akash, additional, Baa, Annie, additional, Kirar, Sudhir, additional, Sharma, Atul, additional, Bakhshi, Sameer, additional, Gogia, Ajay, additional, Malik, Prabhat Singh, additional, Rastogi, Sameer, additional, Batra, Atul, additional, Pushpam, Deepam, additional, Kataria, Babita, additional, Sagiraju, Hari, additional, Sharma, Aparna, additional, and Singh, Vishwajeet, additional

Published
2023
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36. Prognostic relevance of NPM1, CEBPA, and FLT3 mutations in cytogenetically normal adult AML patients

Author

Ningombam, Aparna, Verma, Deepak, Kumar, Rajive, Singh, Jay, Ali, M Shadab, Pandey, Avanish Kumar, Singh, Inder, Bakhshi, Sameer, Sharma, Atul, Pushpam, Deepam, Palanichamy, Jayanth Kumar, Tanwar, Pranay, Singh, Amar Ranjan, and Chopra, Anita

Subjects
Original Article
Abstract

Background: Acute myeloid leukemia with normal cytogenetics (CN-AML) is the largest group of AML patients with very heterogenous patient outcomes. The revised World Health Organization classification of the hematolymphoid tumours, 2022, has incorporated AML with Nucleophosphmin1 (NPM1) and CCAAT/enhancer binding protein-alpha (CEBPA) mutations as distinct entities. Despite the existing evidence of the prognostic relevance of FMS-like tyrosine kinase-3 internal tandem duplication (FLT3-ITD) in AML, it has not been included in the revised classification. Method: In this prospective study, we determined the prevalence of NPM1, CEBPA, and FLT3 gene mutations in 151 de novo CN-AML adult patients (age ≥18 years) in a tertiary care hospital in north India. Additionally, the prognostic relevance of these mutations was also evaluated. Results: NPM1, FLT3-ITD, and CEBPA mutations were found in 33.11%, 23.84%, and 15.77% of CN-AML patients, respectively. CEBPA mutations were found at 3 domains: transactivation domain 1 (TAD1) in 10 (6.62%), transactivation domain 2 (TAD2) in 5 (3.31%), and basic leucine zipper domain (bZIP) in 11 (7.82%) patients. Patients with NPM1 mutation had better clinical remission rate (CR) (P=0.003), event-free survival (P=0.0014), and overall survival (OS) (P=0.0017). However, FLT3-ITD and CEBPA mutations did not show any association with CR (P=0.404 and 0.92, respectively). Biallelic CEBPA mutations were found in 12 (7.95%) patients and were associated with better OS (P=0.043). Conclusions: These findings indicate that NPM1 and CEBPA mutations can be precisely used for risk stratification in CN-AML patients.

Published
2023

37. Improving the performance status in Advanced non-small cell lung cancer patients with Chemotherapy (ImPACt trial): a phase 2 study

Author

Pathak, Neha, primary, Garg, Rakesh, additional, Khurana, Sachin, additional, Kumar, Sudhir, additional, Kumar, Akash, additional, Pushpam, Deepam, additional, Khan, Maroof Ahmad, additional, Mohan, Anant, additional, Pathy, Sushmita, additional, Yadav, Mukesh, additional, Prasad, Chandra Prakash, additional, and Malik, Prabhat Singh, additional

Published
2022
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39. Clinical and Prognostic Impact of Copy Number Alterations and Associated Risk Profiles in a Cohort of Pediatric B-cell Precursor Acute Lymphoblastic Leukemia Cases Treated Under ICiCLe Protocol

Author

Gupta, Sanjeev Kumar, primary, Singh, Minu, additional, Chandrashekar, Pragna H., additional, Bakhshi, Sameer, additional, Trehan, Amita, additional, Gupta, Ritu, additional, Thakur, Rozy, additional, Gajendra, Smeeta, additional, Sharma, Preity, additional, Sreedharanunni, Sreejesh, additional, Sachdeva, Manupdesh S., additional, Pushpam, Deepam, additional, Varma, Neelam, additional, Bansal, Deepak, additional, Jain, Richa, additional, Peyam, Srinivasan, additional, Moorman, Anthony V., additional, and Bhatia, Prateek, additional

Published
2022
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41. Concerns of health care professionals managing non-COVID patients during the COVID-19 pandemic: A descriptive cross-sectional study

Author

Sarma, Riniki, Vig, Saurabh, Rathore, Puneet, Pushpam, Deepam, Mishra, Seema, Gupta, Nishkarsh, Garg, Rakesh, Kumar, Vinod, Bharati, Sachidanand, and Bhatnagar, Sushma

Subjects
United States. Centers for Disease Control and Prevention -- Management, Coronaviruses, Epidemics -- China, Medical personnel, COVID-19, Company business management, Health
Abstract

Byline: Riniki. Sarma, Saurabh. Vig, Puneet. Rathore, Deepam. Pushpam, Seema. Mishra, Nishkarsh. Gupta, Rakesh. Garg, Vinod. Kumar, Sachidanand. Bharati, Sushma. Bhatnagar Context: The coronavirus pandemic has put an unprecedented burden [...]

Published
2020

44. Prognostic utility of key copy number alterations in T cell acute lymphoblastic leukemia

Author

Kumari, Sarita, primary, Ali, M. Shadab, additional, Singh, Jay, additional, Arora, Mohit, additional, Verma, Deepak, additional, Pandey, Avanish Kumar, additional, Benjamin, Mercilena, additional, Bakhshi, Sameer, additional, Palanichamy, Jayanth Kumar, additional, Sharma, Atul, additional, Singh, Inder, additional, Tanwar, Pranay, additional, Singh, Amar Ranjan, additional, Pushpam, Deepam, additional, Qamar, Imteyaz, additional, and Chopra, Anita, additional

Published
2022
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45. Olanzapine versus fosaprepitant for prevention of chemotherapy induced nausea and vomiting in patients receiving carboplatin (AUC ≥ 4) containing chemotherapy regimen: A phase 3 randomized, double-blind, placebo-controlled trial.

Author

Bhargave, Sneh, primary, kumar, akash, additional, Sharma, Vinod, additional, Kataria, Babita, additional, Pushpam, Deepam, additional, Batra, Atul, additional, Pramanik, Raja, additional, Khurana, Sachin, additional, Sahoo, Ranjit Kumar, additional, Malik, Prabhat Singh, additional, Bakhshi, Sameer, additional, Sharma, Atul, additional, and Kumar, Lalit, additional

Published
2022
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46. The feasibility of weekly paclitaxel in improving performance status(PS) of advanced non-small cell lung cancer (NSCLC) patients with poor performance status: A single-arm phase two trial.

Author

Pathak, Neha, primary, Garg, Rakesh, additional, Mohan, Anant, additional, kumar, akash, additional, Khurana, Sachin, additional, Pushpam, Deepam, additional, Pathy, Sushmita, additional, Yadav, Mukesh, additional, Prasad, Chandra Prakash, additional, and Malik, Prabhat Singh, additional

Published
2022
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